pre-miRNA Information
pre-miRNA hsa-mir-6888   
Genomic Coordinates chr2: 159186835 - 159186901
Description Homo sapiens miR-6888 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6888-5p
Sequence 6| AAGGAGAUGCUCAGGCAGAU |25
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766276740 4 dbSNP
rs1348014091 6 dbSNP
rs755543842 16 dbSNP
rs1224830578 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CEP97   
Synonyms 2810403B08Rik, LRRIQ2
Description centrosomal protein 97
Transcript NM_024548   
Expression
Putative miRNA Targets on CEP97
3'UTR of CEP97
(miRNA target sites are highlighted)
>CEP97|NM_024548|3'UTR
   1 CATGTCTTTTGGGAGGCAGATATCCACTTAACTTTTCTTAAAAATACTTTCAGTTGCCTTTGCTTTTTTTTGGAGGGAAA
  81 TACTCCCTACCCCTAATTTTGTTACTACTTATATAGAATTTGTATTCATGTCTTATATTTTTCAGATTCTAGATATTGAG
 161 CTGAGTTTTCATTTTGATTTTGTTAGCTTTTTACTTAGCTGTAAGGTACCAAACTATTTATATTGAAAGCTATATGCACT
 241 TTATTTCTTAACTGAATTGCATCAACAATGTTCCTGTTTCTTTCATGTACTCATTTACTTTCAAAAATAAGCTAGAATAT
 321 ATTAAAGAAAATAGAAAAAATTACCTTAAATATATAAATAAGAGAATTTTGGCCCTTCTGTGTCTGAGAAAATTAATTAT
 401 ATAGCAAGGAATGAAATTTGATAAAGCAAATATAAATGAGAAATATGAGGATTGTGAATTATTGAAATTTGCCAGTCTCC
 481 CTGGTGTAAAATGTTTTTTTAAAGCCTTTTTTCCTCCTTTCGGAGTCAAGGAAAGCCTTTCTATAAGCAAATTAAGGAAG
 561 AAAAGGTAGGATTATAAGATTTCTCAATGGGGATGATTAAATTGTCTCATGGAAAACTTCAGTTAATGTCATGCATCAGT
 641 TTTAACATATGAAGTAAAGTGTTCTATCCAGGATTAAAGTCAAGTTTACTTAGGCAACACAAGAATATTTCACTTAGATA
 721 TGAAGAAAGGAAACACTAGTCTCCATTCACTTGAAATACTCTCATGGCAAATATTTATCCTCTCATTAAGTGCTTTTTCA
 801 CCCTATAGGTAAGCATTTTTGTGCCAACATGTTGTCAGAAATTAATGTATGTTCATCTCCTCTGTTCCTGCTTATTTTTA
 881 CTTATATATTTCAGCAGAAGGTCCGTGGCCATTCACTTCAATTTTGACCTCTGTCCCATAGTGAAGAACATTTAAAGTAA
 961 TACTACTGGTCGAATATGAATGACTTTTTAGGAACTACTTTTTGTCTAACCTGAAAAAGTTCCACATTTGGAAGACAATT
1041 TAATGATGGTGAAGAAATAATAAACCTCACTTTACTTGTTAAAAGGGATATATATATATATATATATGTCTGCAACTTCA
1121 GGGAGAAATAAGATTGTGTTTGAATATTGTAGGTAGATGCATTTGTAATTAAGGATAATATCGTTTAACAACATGTATTT
1201 GGTTTCCCTCAACTTACAGACATACAGCTATTTAAAACTATGGCAATACTTAAGCATCTCTAAATTTAGGTGCTAAATAT
1281 CTATTATTCTGTTGTAGTCATTAGGTGCCCTTCTCTGAAGTTATGTAAAATAAAAGCATCTGATCCTTCAAGGATAAAGT
1361 TGAGGATCACATGGTACGTGGCATTTGTTGTTATTGTTTTTTAAAGAGATGGAGGCTGGCTCTGTTGGTGCGGTGCCATG
1441 ATCATAGTTCACTATAACCTCGAACTCCTGGCTCAAGTGATCTCCCACTTCAGCCTCCCGAGTATCTGGGATTATAAGCA
1521 AGAGCCACTGCTCCCAGCTCATGGTATTTGTTGATAGTCATAACATTTTTCCTGTATGGTAAGACGTATTTTTCTCAGTT
1601 TATAAATACGTAGCACTCAGGTTGAGACGACTTGGATTTTATTCTTAGAAATCCAGAATCCCTTGAAAAGGAAATATTTT
1681 CTGTTTCTTATAAATAAAAGAGTAATCTTACTTTCAGAAGGATTTTCCTTAGTGAAACATGTGTAACATTGAATGCATGT
1761 TAAATAAAAATGGAATTTCTAACTTTTTTTCAATAGTGCTAATTATCTTTTCTGAATGATTTTGAATGTCTTCTTAAATA
1841 TACCCTATTTTTCTATTTTAAAGTTAAGTGCCTCACTTGCTGTCCATAGTTAGACAAAGAAAAACCAATTTCCACTGCAC
1921 TAGTACCAAAATACTACTTTATACATTAGTTTTTCATAAAAGCTGCTGGAATGTCATGATTCAGTATTACCTAAATAGAT
2001 TTCTGCTAAAATCCTCTCCCTCCTGTCTTTTTTAAGTTATGGAAAAACACAACTAAATTCATTTGATCATCAGCACTTGT
2081 TAGCAGGATTTCCTTTTTTACCTTTGCCTTGTTTCTTTAGCCCACAAATAGTACTCAGCATACTTTCATTAAAAATTTGG
2161 CACAATATGATAATTGTTAATATTCTGTTCTTCGTCTGTGTTTTATTTAACTTTTACTAGTGTTTAGAAGTGCAAGAATA
2241 TTAAATAGCCCCTTCCTTAACTGTACATATTATCTTGAATGTAGATAAAATGAAAATACTGTAAATTAGAGTGTAGGAAA
2321 ACTGGCATAGAGTTAATATATTTTAATGGGTTTACATTATACTTTAAAAGTAATTTATATAATTAAAATATTTGGTTTTA
2401 ACTCTATGGGCTATTCTTTGGTTGGCTGAAGAGGGAATGGGTCTAGTAAGGTTTGGAAAGTTAAGCTTTGAACATGGTCT
2481 TTGTGTTTTTTTCCTAACAAGGAAAGGTTTAGTTCAGCTGTGCTATTTTAGTACACATCAGTTCTCTTGATTTATGGAAG
2561 ATTCAGTTTATCAATTAAGAATTCCTGCAGAAGCACAGAATCATACCATGTAAGAGTTGGAAGGAAGCTTAAGAGATTTC
2641 TGTTCGAATCTCTTTGTTTCAAAGATGAAACTAAAGCACAGCATGTTAAATGACTTGTCTAAGTTATAGCTAGTTAGTAG
2721 TAAATAAACTGAAAACCTATATGCTACTGTAGTCCAAAATTTTATTATGTCCTCTTAATCTTTACATTTAGTGAGTCAGT
2801 AAGGAAATCTCTGCATATTTCTCATTCTCTTTGAAAGAGGAAAAAAACTTCTAAGAGAGCTACAACTCTATCACTCATGA
2881 CAGAGTTGCTTGTAGAAAATAACTAATTCCTTCAGAACCCTGAGTGAATTTTTTCTAAGAAATGTGACTTGATTAAAATG
2961 GTTTCAAAAGAGCAATAGTGGAAATTAAAGTTTTAGAAAAGAGACCTGGCGTGGTGGTTGACAACTGTAATCCCAGTGCT
3041 TTGGGAGGCTGAGGCCAGAGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGACAACATAGCAAGACCCCCCTCTCT
3121 ACAAAAAAAATTTTTTTCTGAAAAGAATAAGTACATTTTAGAGTCCATTTATTTGACGACAGGCAGTATGACAGGTTGCT
3201 GAGGTATATAAAATTTTCTAGAGAAATGCTGAGTTTGATGACATTTTATCTTCAGTTTTGTAGAACAGATGTTAAAATGT
3281 TAACTCTCCTGGTGTGCAGAAAGCTGTAATCATGACAGTTGATAATATGCAATTTAGTTTGATTTTATAGGTTTAATTAT
3361 AAAAGGCTTCACAATATGCATGTTTTAGGAAAATGTTCATTTATTTAGTCATATAATCGTTTGTATATATGTAAATAACT
3441 TTATTCTGGAATAATGTGGGTGCCATCTTGAGCGTGTGTTTTTATCTGTTTTGGATTATTTTTTGTATACAAACACCATA
3521 ATACTGTATTTTCCTGTTATCTACTTAAGTCTAGTTCTACTTTTTCCCAATAATTTCAGGAAAATACAAGCTTGAGATAT
3601 TATACTATCTCCCTTGGTATTTTTTGTGTGCAAAGTCTTAGAATTGGATTTATAACATTGATAATAAAAATATAAAACGT
3681 TTTTCCTCGGGAGTTAAGATGGTAAAAAGAAAAAAATAGAATGAATATGATCATTTCTCCATCATAAAGGAAAGAAGAGA
3761 CTTCATTGTGTGTGTGTTTTTTTTTTTTTTTTCGAGATAGAGTTTCACTGTTGTCACCCAGGCTGGTCTCAGCTCACTGC
3841 AACCTCCACTTCCTGGGTACAAGCGATTCTCCTGCCTCAGCTTCCTGTGTAGCTGGGATTACAGGTGTGCAACCACAAGG
3921 CTCGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAA
4001 GTGATCCACCCACCTCGGCCTCGCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCAGCCGAGACTTCATTGTTTA
4081 ATGTATATTTTTATTTTTTCCAAACACCAGCTCGAATCAGAGTATATTTTTATTTTGCCACATACCTTTAAAAGGTATTT
4161 ATTGTGTCATAATGTTTTAAATGTTAAATATATGATACCCTCATTCATGAAGTGAAGCAGAAAGGGTCTGTAAGGAACAT
4241 TCTAAACATTTTTAATGATATTGCTTTTACTGATCAAGCTTGTTGTGCCATATTAAAATTAAAAGTCAAATAAACAAAGC
4321 AGTCCTCACAGCCTTGGAAAGAAATAGATAATTGTCTTCTTAAGATGAGGTGCTTTTTATCTGTGGATGAATGGAAATCA
4401 CACTGAATTTTAATTCTTATTTATTTTAGTGGATAGCAGGAATCACTCTGTAGTAGTTGTGTTCATTTTCTTTTCTTTTT
4481 CTTTTCTTTTTTTTGAGAGAGTCTCGCTCTGTCACCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCA
4561 TCTCCTGGGTTCAAGTGATTCTCCTGCCTCATCCTCCCGAGTAGCTAAGACTACAGGCACACGCCACCATGCCCAGCTAA
4641 TTTTTATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCAATCTCTTGACCTCGTGATCCACCCAG
4721 TTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTACACCTGGCCTTGTTCATCTTCTAATTAAATATCTTTGA
4801 ATGTTTTGTAATAATTTTAATGTTGACAATAAGAGTTTAAAAATAATTTGATTTTGGACTGTATTTAGATTTCTCTTTAA
4881 TTTTGCTGTAGAAATAGTAAATGATTTAAAGTGGTTATGATGTGTTTTATGAAGGCTTACTATTTTATATTGTACTTATT
4961 TAATTTGTATTTGAGTCTGTCTAATTTTAAATAAAAGGTTTATACATTTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uagACGGACUCGUAGAGGAa 5'
             ||: ||  |||||||| 
Target 5' taaTGTATGTTCATCTCCTc 3'
843 - 862 157.00 -14.10
2
miRNA  3' uaGAC---GGACUCGUAGAGGAa 5'
            |||   |||   |||||||| 
Target 5' caCTGCAACCT--CCATCTCCTg 3'
4547 - 4567 150.00 -16.60
3
miRNA  3' uaGAC--GGACUCGUAGAGGAa 5'
            |||  |:||  |||||:|| 
Target 5' acCTGGCCTTGTTCATCTTCTa 3'
4764 - 4785 144.00 -14.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN8487805 7 COSMIC
COSN30482539 26 COSMIC
COSN30154800 47 COSMIC
COSN30178815 63 COSMIC
COSN18727416 72 COSMIC
COSN30506718 72 COSMIC
COSN26970471 77 COSMIC
COSN31576977 103 COSMIC
COSN31546987 117 COSMIC
COSN30106360 119 COSMIC
COSN31545595 177 COSMIC
COSN31556905 238 COSMIC
COSN9732216 402 COSMIC
COSN31568690 416 COSMIC
COSN8361291 439 COSMIC
COSN22738871 523 COSMIC
COSN7548401 633 COSMIC
COSN22577343 731 COSMIC
COSN26565268 902 COSMIC
COSN24300081 1075 COSMIC
COSN20098799 1107 COSMIC
COSN20098798 1108 COSMIC
COSN25405220 1398 COSMIC
COSN29395215 1459 COSMIC
COSN32063894 1619 COSMIC
COSN1902029 1737 COSMIC
COSN20781169 2061 COSMIC
COSN7548402 2268 COSMIC
COSN9107517 2561 COSMIC
COSN16507762 3129 COSMIC
COSN17245763 3133 COSMIC
COSN9732217 3458 COSMIC
COSN20265902 3655 COSMIC
COSN23870488 3879 COSMIC
COSN25702756 3925 COSMIC
COSN9732218 3930 COSMIC
COSN1902030 3994 COSMIC
COSN4996152 4962 COSMIC
COSN15301238 4999 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs373512454 2 dbSNP
rs201988050 4 dbSNP
rs1418795534 7 dbSNP
rs748177072 11 dbSNP
rs1460760326 16 dbSNP
rs772130647 17 dbSNP
rs1402455427 18 dbSNP
rs181347869 24 dbSNP
rs769041935 24 dbSNP
rs776453554 28 dbSNP
rs1448503808 29 dbSNP
rs1312201457 30 dbSNP
rs759427281 31 dbSNP
rs1229001578 34 dbSNP
rs1338333769 36 dbSNP
rs765056137 37 dbSNP
rs1486573218 45 dbSNP
rs1260516146 51 dbSNP
rs930058433 62 dbSNP
rs1359793149 63 dbSNP
rs1294385140 64 dbSNP
rs1192460347 65 dbSNP
rs1321601469 69 dbSNP
rs1425354224 81 dbSNP
rs1296950701 89 dbSNP
rs1413570611 89 dbSNP
rs1047630985 102 dbSNP
rs1359964967 108 dbSNP
rs1297741048 114 dbSNP
rs907194139 115 dbSNP
rs1405771968 116 dbSNP
rs948193733 130 dbSNP
rs1165201432 133 dbSNP
rs1456224409 135 dbSNP
rs1049335365 137 dbSNP
rs569981113 138 dbSNP
rs537384063 139 dbSNP
rs1002884048 150 dbSNP
rs887993806 151 dbSNP
rs926787706 153 dbSNP
rs1422031711 157 dbSNP
rs1299398536 162 dbSNP
rs943072559 162 dbSNP
rs1015672776 163 dbSNP
rs558549719 187 dbSNP
rs1490402695 188 dbSNP
rs1270638792 203 dbSNP
rs1340479886 207 dbSNP
rs896932411 215 dbSNP
rs1488367903 217 dbSNP
rs894749847 225 dbSNP
rs576817998 230 dbSNP
rs1029392722 233 dbSNP
rs563439164 235 dbSNP
rs985660834 236 dbSNP
rs967971790 238 dbSNP
rs977864194 254 dbSNP
rs1031201049 260 dbSNP
rs1389753063 261 dbSNP
rs955007073 269 dbSNP
rs968360262 275 dbSNP
rs1398085581 279 dbSNP
rs145590054 288 dbSNP
rs986431553 303 dbSNP
rs911113185 309 dbSNP
rs552655089 310 dbSNP
rs942633540 328 dbSNP
rs923923929 335 dbSNP
rs978154883 335 dbSNP
rs1432307828 342 dbSNP
rs974421925 343 dbSNP
rs1456803802 355 dbSNP
rs756698386 363 dbSNP
rs919768473 375 dbSNP
rs1325777382 381 dbSNP
rs1487270816 383 dbSNP
rs1273235551 389 dbSNP
rs1223055865 394 dbSNP
rs1232804447 397 dbSNP
rs929833781 402 dbSNP
rs758611523 422 dbSNP
rs1049687617 428 dbSNP
rs909506899 433 dbSNP
rs1397963831 444 dbSNP
rs940921444 445 dbSNP
rs1036727946 448 dbSNP
rs1407647774 450 dbSNP
rs1047109494 455 dbSNP
rs896840058 463 dbSNP
rs1465210309 485 dbSNP
rs1364054466 487 dbSNP
rs997830744 492 dbSNP
rs1050835283 494 dbSNP
rs889507956 498 dbSNP
rs907285213 502 dbSNP
rs1463104231 507 dbSNP
rs1006757142 508 dbSNP
rs1276575607 514 dbSNP
rs185942488 522 dbSNP
rs938642384 523 dbSNP
rs1262738229 531 dbSNP
rs1241975397 537 dbSNP
rs780299083 544 dbSNP
rs1308345436 548 dbSNP
rs1453265977 563 dbSNP
rs1441882108 566 dbSNP
rs968013851 567 dbSNP
rs938141558 571 dbSNP
rs1331583514 573 dbSNP
rs999836483 586 dbSNP
rs1385170224 590 dbSNP
rs1360381172 591 dbSNP
rs1055818602 599 dbSNP
rs894511277 603 dbSNP
rs1011815341 617 dbSNP
rs1022331699 635 dbSNP
rs1350579794 640 dbSNP
rs542036881 651 dbSNP
rs751903178 655 dbSNP
rs999435451 656 dbSNP
rs750039134 666 dbSNP
rs1447668843 671 dbSNP
rs1264040419 677 dbSNP
rs1379433922 684 dbSNP
rs1214717528 685 dbSNP
rs1030709921 700 dbSNP
rs1240520566 708 dbSNP
rs1246487474 723 dbSNP
rs1308276479 726 dbSNP
rs955142439 734 dbSNP
rs1282381938 742 dbSNP
rs755360894 744 dbSNP
rs1017877163 746 dbSNP
rs1351403885 752 dbSNP
rs1242903842 755 dbSNP
rs563576628 764 dbSNP
rs1326514943 790 dbSNP
rs963720220 803 dbSNP
rs565764573 806 dbSNP
rs530990699 816 dbSNP
rs1289939473 825 dbSNP
rs1450592688 827 dbSNP
rs984999809 830 dbSNP
rs376498088 832 dbSNP
rs909358798 835 dbSNP
rs1218774308 836 dbSNP
rs1163192651 851 dbSNP
rs1476064813 857 dbSNP
rs1239541299 858 dbSNP
rs951208470 861 dbSNP
rs1191656376 867 dbSNP
rs983042053 868 dbSNP
rs189840814 884 dbSNP
rs564613039 886 dbSNP
rs1036636674 900 dbSNP
rs183158784 905 dbSNP
rs1287566151 906 dbSNP
rs1179635884 909 dbSNP
rs1055909387 922 dbSNP
rs541768044 922 dbSNP
rs915913796 939 dbSNP
rs1216299598 958 dbSNP
rs1339400915 966 dbSNP
rs546628606 972 dbSNP
rs568588232 973 dbSNP
rs1348493927 981 dbSNP
rs1165557394 985 dbSNP
rs1415185737 988 dbSNP
rs1404798124 996 dbSNP
rs147739198 1008 dbSNP
rs187931180 1009 dbSNP
rs1403134036 1014 dbSNP
rs1168569850 1026 dbSNP
rs1477547218 1029 dbSNP
rs1430182003 1031 dbSNP
rs1201871181 1033 dbSNP
rs1325328607 1037 dbSNP
rs1244754402 1039 dbSNP
rs1220619562 1053 dbSNP
rs79326900 1067 dbSNP
rs1402656789 1068 dbSNP
rs1438294666 1069 dbSNP
rs1447872556 1069 dbSNP
rs1259953798 1072 dbSNP
rs1196156857 1078 dbSNP
rs62284204 1085 dbSNP
rs1443421586 1088 dbSNP
rs369025672 1088 dbSNP
rs374769023 1088 dbSNP
rs776781828 1088 dbSNP
rs569893335 1089 dbSNP
rs769290829 1090 dbSNP
rs1406922130 1097 dbSNP
rs1178402447 1101 dbSNP
rs536849142 1101 dbSNP
rs868399350 1105 dbSNP
rs1246872947 1108 dbSNP
rs3039557 1108 dbSNP
rs1424778191 1109 dbSNP
rs1190373073 1111 dbSNP
rs1284663264 1112 dbSNP
rs533821362 1116 dbSNP
rs1239859506 1120 dbSNP
rs903437668 1123 dbSNP
rs1355598189 1126 dbSNP
rs1226057960 1152 dbSNP
rs1263193775 1173 dbSNP
rs1211665623 1176 dbSNP
rs756506171 1179 dbSNP
rs371873930 1181 dbSNP
rs1043593698 1182 dbSNP
rs903697437 1183 dbSNP
rs999291089 1184 dbSNP
rs1307620588 1203 dbSNP
rs1237930912 1214 dbSNP
rs1436381953 1217 dbSNP
rs1190085367 1222 dbSNP
rs149230588 1223 dbSNP
rs960577699 1226 dbSNP
rs1052377476 1235 dbSNP
rs1472766392 1239 dbSNP
rs890653146 1240 dbSNP
rs1445955475 1245 dbSNP
rs1162862280 1254 dbSNP
rs777135746 1255 dbSNP
rs190472996 1265 dbSNP
rs1421823989 1269 dbSNP
rs963647201 1278 dbSNP
rs1394637098 1282 dbSNP
rs534636771 1292 dbSNP
rs1256812429 1299 dbSNP
rs1056574036 1310 dbSNP
rs1481994585 1313 dbSNP
rs1236462439 1325 dbSNP
rs1216884159 1326 dbSNP
rs909277727 1331 dbSNP
rs370309238 1337 dbSNP
rs373031757 1339 dbSNP
rs1489101750 1341 dbSNP
rs1334576461 1342 dbSNP
rs1239932535 1349 dbSNP
rs552517841 1355 dbSNP
rs1339786910 1358 dbSNP
rs962527575 1360 dbSNP
rs1226621079 1365 dbSNP
rs972194499 1366 dbSNP
rs1289579635 1371 dbSNP
rs1402052452 1372 dbSNP
rs183507099 1374 dbSNP
rs115732792 1378 dbSNP
rs1418887974 1379 dbSNP
rs986487850 1387 dbSNP
rs982746785 1388 dbSNP
rs377738974 1395 dbSNP
rs942351253 1396 dbSNP
rs1255717341 1404 dbSNP
rs959902924 1407 dbSNP
rs1489050926 1423 dbSNP
rs1043885309 1425 dbSNP
rs575837390 1432 dbSNP
rs774168167 1433 dbSNP
rs947371637 1439 dbSNP
rs1267685393 1440 dbSNP
rs1043470028 1452 dbSNP
rs1321696474 1463 dbSNP
rs935172456 1465 dbSNP
rs1220575720 1470 dbSNP
rs1338641530 1492 dbSNP
rs1052217685 1498 dbSNP
rs759362640 1500 dbSNP
rs934895492 1501 dbSNP
rs1295133387 1532 dbSNP
rs771766313 1554 dbSNP
rs905211719 1561 dbSNP
rs1051990971 1562 dbSNP
rs546037775 1563 dbSNP
rs1478163122 1575 dbSNP
rs1269885384 1576 dbSNP
rs1189879129 1586 dbSNP
rs1007689271 1587 dbSNP
rs1259288994 1602 dbSNP
rs545345342 1610 dbSNP
rs899609056 1611 dbSNP
rs1257576332 1615 dbSNP
rs528749785 1629 dbSNP
rs563746651 1630 dbSNP
rs1432757861 1653 dbSNP
rs6764700 1656 dbSNP
rs1004537089 1675 dbSNP
rs1466671991 1676 dbSNP
rs1035644064 1682 dbSNP
rs1341088183 1684 dbSNP
rs1169398894 1689 dbSNP
rs1398776282 1693 dbSNP
rs1379602550 1696 dbSNP
rs986393046 1696 dbSNP
rs1379037051 1698 dbSNP
rs1292839240 1700 dbSNP
rs1197139318 1705 dbSNP
rs959828982 1715 dbSNP
rs942362267 1716 dbSNP
rs542298347 1739 dbSNP
rs536455375 1744 dbSNP
rs188396206 1748 dbSNP
rs969222022 1750 dbSNP
rs979086615 1754 dbSNP
rs1201151864 1757 dbSNP
rs1347677353 1759 dbSNP
rs978898626 1763 dbSNP
rs1209209107 1784 dbSNP
rs545912852 1784 dbSNP
rs935064690 1784 dbSNP
rs896337537 1791 dbSNP
rs112906893 1799 dbSNP
rs57874127 1818 dbSNP
rs1330042624 1820 dbSNP
rs1045392078 1821 dbSNP
rs1403826064 1823 dbSNP
rs905076692 1835 dbSNP
rs1006670891 1840 dbSNP
rs1381296274 1842 dbSNP
rs934713111 1843 dbSNP
rs529281544 1844 dbSNP
rs750443336 1849 dbSNP
rs897933812 1856 dbSNP
rs551142053 1864 dbSNP
rs1444213990 1869 dbSNP
rs1254259862 1872 dbSNP
rs1199908715 1885 dbSNP
rs912147132 1887 dbSNP
rs1488774226 1889 dbSNP
rs1286426609 1899 dbSNP
rs1242088258 1907 dbSNP
rs1351353707 1909 dbSNP
rs763073686 1916 dbSNP
rs1244793230 1917 dbSNP
rs1039188985 1924 dbSNP
rs899358038 1926 dbSNP
rs1377304653 1938 dbSNP
rs954875991 1952 dbSNP
rs986276390 1966 dbSNP
rs562961344 1968 dbSNP
rs1418283514 1970 dbSNP
rs1048179760 1976 dbSNP
rs968988729 1977 dbSNP
rs530736013 1986 dbSNP
rs1474098688 2005 dbSNP
rs1366784831 2015 dbSNP
rs1361026023 2016 dbSNP
rs1186981691 2023 dbSNP
rs979532105 2026 dbSNP
rs1286608319 2028 dbSNP
rs1265640675 2047 dbSNP
rs886769020 2064 dbSNP
rs1218444185 2066 dbSNP
rs924960035 2075 dbSNP
rs751813439 2082 dbSNP
rs1283375106 2101 dbSNP
rs1210344855 2116 dbSNP
rs1392308702 2121 dbSNP
rs956345726 2125 dbSNP
rs1232186513 2128 dbSNP
rs987869370 2129 dbSNP
rs917628546 2132 dbSNP
rs374541011 2134 dbSNP
rs1003892684 2138 dbSNP
rs1035569197 2148 dbSNP
rs895755768 2150 dbSNP
rs1044900512 2153 dbSNP
rs1164239227 2158 dbSNP
rs1012728116 2161 dbSNP
rs755270863 2166 dbSNP
rs1232468867 2167 dbSNP
rs1425966876 2167 dbSNP
rs150530683 2192 dbSNP
rs534682710 2192 dbSNP
rs1355040588 2194 dbSNP
rs367865389 2195 dbSNP
rs1259014219 2197 dbSNP
rs1287674537 2199 dbSNP
rs1212464640 2206 dbSNP
rs1038133778 2223 dbSNP
rs552058783 2225 dbSNP
rs1210541253 2234 dbSNP
rs1360901461 2235 dbSNP
rs968604981 2241 dbSNP
rs1439076896 2249 dbSNP
rs993471774 2250 dbSNP
rs979253050 2253 dbSNP
rs1329796468 2256 dbSNP
rs1031763259 2257 dbSNP
rs1467320627 2258 dbSNP
rs1180262561 2262 dbSNP
rs1325828307 2264 dbSNP
rs1051851146 2268 dbSNP
rs1438975186 2270 dbSNP
rs956194627 2281 dbSNP
rs1168679269 2283 dbSNP
rs1409570945 2293 dbSNP
rs1426180589 2295 dbSNP
rs1156899179 2300 dbSNP
rs1370146242 2308 dbSNP
rs781425304 2308 dbSNP
rs1478896721 2310 dbSNP
rs192861814 2312 dbSNP
rs943609506 2314 dbSNP
rs1458204792 2316 dbSNP
rs1008175167 2329 dbSNP
rs974987690 2331 dbSNP
rs1306508764 2341 dbSNP
rs142505306 2350 dbSNP
rs1221227970 2352 dbSNP
rs969405785 2357 dbSNP
rs377402286 2379 dbSNP
rs1413508805 2390 dbSNP
rs930863282 2396 dbSNP
rs1387459772 2402 dbSNP
rs1448134894 2404 dbSNP
rs1000465692 2407 dbSNP
rs1031861779 2408 dbSNP
rs769242641 2414 dbSNP
rs1359906724 2417 dbSNP
rs956376787 2425 dbSNP
rs1393023911 2470 dbSNP
rs917701820 2474 dbSNP
rs1440205020 2475 dbSNP
rs562116517 2477 dbSNP
rs908290259 2480 dbSNP
rs939645567 2483 dbSNP
rs1237615994 2484 dbSNP
rs1211779362 2485 dbSNP
rs941827043 2486 dbSNP
rs1280019579 2497 dbSNP
rs546469858 2499 dbSNP
rs1391197343 2500 dbSNP
rs1037640921 2506 dbSNP
rs1223229075 2524 dbSNP
rs13066768 2526 dbSNP
rs1324032428 2536 dbSNP
rs1245536900 2538 dbSNP
rs895513290 2550 dbSNP
rs929299074 2555 dbSNP
rs201677727 2558 dbSNP
rs778393948 2558 dbSNP
rs1312006295 2569 dbSNP
rs1420093653 2570 dbSNP
rs748758084 2575 dbSNP
rs1362305204 2584 dbSNP
rs1238540117 2601 dbSNP
rs1418490952 2604 dbSNP
rs1413853505 2609 dbSNP
rs890583912 2610 dbSNP
rs1007631209 2611 dbSNP
rs1217733752 2614 dbSNP
rs1012821257 2624 dbSNP
rs1489479721 2632 dbSNP
rs1284412921 2641 dbSNP
rs770594423 2646 dbSNP
rs1322903811 2647 dbSNP
rs1044359697 2653 dbSNP
rs904321370 2655 dbSNP
rs77225242 2663 dbSNP
rs1354991711 2666 dbSNP
rs1279081648 2679 dbSNP
rs904709011 2680 dbSNP
rs772034325 2684 dbSNP
rs1342127209 2685 dbSNP
rs770591273 2685 dbSNP
rs1452927702 2696 dbSNP
rs1163449827 2700 dbSNP
rs527435492 2701 dbSNP
rs150933604 2711 dbSNP
rs1032148147 2713 dbSNP
rs1466839686 2715 dbSNP
rs956161091 2719 dbSNP
rs1170882702 2721 dbSNP
rs1166223831 2730 dbSNP
rs1399129226 2732 dbSNP
rs1008963842 2737 dbSNP
rs1193932639 2740 dbSNP
rs1031894296 2750 dbSNP
rs569419094 2751 dbSNP
rs1186340934 2754 dbSNP
rs1489070914 2769 dbSNP
rs1267780218 2770 dbSNP
rs1381953880 2775 dbSNP
rs1397190269 2779 dbSNP
rs1334248076 2781 dbSNP
rs1292744132 2786 dbSNP
rs556645323 2799 dbSNP
rs964718885 2806 dbSNP
rs1353706334 2819 dbSNP
rs539951066 2822 dbSNP
rs1258861513 2835 dbSNP
rs974955146 2839 dbSNP
rs575199558 2860 dbSNP
rs1009229854 2864 dbSNP
rs1024580295 2866 dbSNP
rs866358182 2875 dbSNP
rs1368141383 2884 dbSNP
rs1295227159 2887 dbSNP
rs1257589707 2904 dbSNP
rs1170837677 2905 dbSNP
rs778639939 2908 dbSNP
rs980557828 2910 dbSNP
rs1187211809 2914 dbSNP
rs1033821643 2916 dbSNP
rs1434133619 2917 dbSNP
rs1478479913 2918 dbSNP
rs983657923 2919 dbSNP
rs908261204 2920 dbSNP
rs1468464655 2927 dbSNP
rs973198683 2934 dbSNP
rs919208431 2938 dbSNP
rs1337637133 2946 dbSNP
rs939740756 2951 dbSNP
rs745527344 2954 dbSNP
rs1226337554 2977 dbSNP
rs1193795515 2980 dbSNP
rs1312556021 2982 dbSNP
rs929205787 2998 dbSNP
rs987492883 3003 dbSNP
rs540043733 3005 dbSNP
rs911909380 3006 dbSNP
rs551767616 3007 dbSNP
rs916917448 3011 dbSNP
rs1393802578 3012 dbSNP
rs569728823 3012 dbSNP
rs184840387 3015 dbSNP
rs1443916310 3024 dbSNP
rs943342006 3025 dbSNP
rs1044666159 3033 dbSNP
rs1361330622 3038 dbSNP
rs904457070 3046 dbSNP
rs1381498766 3049 dbSNP
rs573369001 3060 dbSNP
rs1374176362 3068 dbSNP
rs773554284 3072 dbSNP
rs760746114 3084 dbSNP
rs1201236463 3088 dbSNP
rs1278938440 3089 dbSNP
rs1361499048 3096 dbSNP
rs114718981 3100 dbSNP
rs1282159312 3103 dbSNP
rs936219366 3110 dbSNP
rs562366048 3112 dbSNP
rs1008932529 3114 dbSNP
rs1019017913 3115 dbSNP
rs1305727815 3116 dbSNP
rs1333462125 3116 dbSNP
rs1396216946 3117 dbSNP
rs200014984 3123 dbSNP
rs1403944851 3124 dbSNP
rs1209900231 3131 dbSNP
rs2611839 3132 dbSNP
rs544571121 3133 dbSNP
rs775139191 3134 dbSNP
rs952345085 3146 dbSNP
rs984138432 3152 dbSNP
rs908019209 3157 dbSNP
rs963449158 3162 dbSNP
rs960903558 3168 dbSNP
rs992570592 3169 dbSNP
rs186738839 3178 dbSNP
rs533236565 3182 dbSNP
rs534594498 3185 dbSNP
rs1173439684 3191 dbSNP
rs1206797441 3195 dbSNP
rs987404591 3214 dbSNP
rs1393752920 3219 dbSNP
rs1244910454 3226 dbSNP
rs1356910324 3234 dbSNP
rs1291062575 3241 dbSNP
rs979804570 3244 dbSNP
rs866100332 3249 dbSNP
rs1319026179 3255 dbSNP
rs1320748957 3272 dbSNP
rs1399433716 3276 dbSNP
rs367941984 3280 dbSNP
rs1344750854 3284 dbSNP
rs975143142 3284 dbSNP
rs1428744021 3289 dbSNP
rs140751787 3291 dbSNP
rs926100090 3292 dbSNP
rs1295443044 3293 dbSNP
rs1368614457 3294 dbSNP
rs936071374 3297 dbSNP
rs1195093143 3308 dbSNP
rs1445161503 3326 dbSNP
rs925637533 3339 dbSNP
rs1260972690 3341 dbSNP
rs1209842784 3342 dbSNP
rs1053247603 3343 dbSNP
rs1233234500 3344 dbSNP
rs1270790264 3345 dbSNP
rs1301042534 3348 dbSNP
rs144696861 3353 dbSNP
rs935913737 3354 dbSNP
rs1318202643 3363 dbSNP
rs950194984 3373 dbSNP
rs1429094111 3378 dbSNP
rs1045963589 3389 dbSNP
rs1324790513 3390 dbSNP
rs746857489 3397 dbSNP
rs906073423 3408 dbSNP
rs1392345201 3411 dbSNP
rs1001910486 3419 dbSNP
rs1282926351 3420 dbSNP
rs1474306290 3427 dbSNP
rs1033760899 3434 dbSNP
rs1199470905 3436 dbSNP
rs1469807100 3437 dbSNP
rs564157045 3438 dbSNP
rs994575532 3447 dbSNP
rs1053482806 3457 dbSNP
rs950533409 3468 dbSNP
rs1213112078 3471 dbSNP
rs1339138307 3473 dbSNP
rs891620456 3474 dbSNP
rs1246884619 3475 dbSNP
rs1237101361 3495 dbSNP
rs759457850 3498 dbSNP
rs1369466699 3499 dbSNP
rs944548115 3500 dbSNP
rs1008702811 3506 dbSNP
rs1040400195 3507 dbSNP
rs1467769374 3511 dbSNP
rs1193373741 3514 dbSNP
rs138648539 3517 dbSNP
rs964984871 3519 dbSNP
rs1159598652 3520 dbSNP
rs1418503392 3523 dbSNP
rs776575120 3525 dbSNP
rs762983810 3527 dbSNP
rs78136795 3537 dbSNP
rs1005133119 3541 dbSNP
rs1439782061 3544 dbSNP
rs567976426 3555 dbSNP
rs1167032950 3558 dbSNP
rs957341172 3570 dbSNP
rs774500423 3575 dbSNP
rs960831741 3584 dbSNP
rs1378912969 3591 dbSNP
rs1346265274 3598 dbSNP
rs992345255 3598 dbSNP
rs1303318508 3601 dbSNP
rs373657649 3604 dbSNP
rs1241587747 3608 dbSNP
rs78070847 3613 dbSNP
rs1277903783 3620 dbSNP
rs950225644 3622 dbSNP
rs759665929 3625 dbSNP
rs550129453 3632 dbSNP
rs1313211881 3634 dbSNP
rs13316216 3635 dbSNP
rs140329021 3644 dbSNP
rs935697819 3645 dbSNP
rs1409506901 3646 dbSNP
rs1175001688 3647 dbSNP
rs1196825174 3649 dbSNP
rs1469262346 3658 dbSNP
rs1257795224 3661 dbSNP
rs1190426701 3663 dbSNP
rs752744158 3663 dbSNP
rs988708876 3676 dbSNP
rs767847688 3679 dbSNP
rs752973808 3680 dbSNP
rs1319296243 3684 dbSNP
rs145490342 3689 dbSNP
rs1223315156 3690 dbSNP
rs1211507625 3691 dbSNP
rs1295356943 3701 dbSNP
rs1008776445 3705 dbSNP
rs1019177331 3708 dbSNP
rs28694790 3709 dbSNP
rs1346915332 3710 dbSNP
rs1454210539 3710 dbSNP
rs28376946 3710 dbSNP
rs547188109 3716 dbSNP
rs1399617491 3717 dbSNP
rs932068068 3724 dbSNP
rs1166629484 3725 dbSNP
rs1418031987 3725 dbSNP
rs1474048317 3726 dbSNP
rs1049652023 3728 dbSNP
rs1187504474 3730 dbSNP
rs1487109520 3737 dbSNP
rs887776849 3738 dbSNP
rs964689592 3740 dbSNP
rs1005300811 3742 dbSNP
rs1322405155 3747 dbSNP
rs1183642738 3765 dbSNP
rs1231665607 3767 dbSNP
rs996512241 3770 dbSNP
rs1292391710 3775 dbSNP
rs1260905167 3777 dbSNP
rs1363899315 3777 dbSNP
rs754209792 3777 dbSNP
rs1032902339 3778 dbSNP
rs1394545000 3778 dbSNP
rs1418752193 3779 dbSNP
rs1461107273 3780 dbSNP
rs957368729 3784 dbSNP
rs76874307 3786 dbSNP
rs13077925 3787 dbSNP
rs1417902926 3791 dbSNP
rs1186437157 3793 dbSNP
rs1327960084 3794 dbSNP
rs184905958 3795 dbSNP
rs1450172252 3796 dbSNP
rs1468156529 3799 dbSNP
rs1293361400 3807 dbSNP
rs971450740 3810 dbSNP
rs1309024894 3814 dbSNP
rs1354331530 3825 dbSNP
rs1230931790 3826 dbSNP
rs981656539 3833 dbSNP
rs1327275082 3841 dbSNP
rs1438096411 3845 dbSNP
rs1393195609 3852 dbSNP
rs1298391306 3854 dbSNP
rs1375683294 3855 dbSNP
rs138081815 3865 dbSNP
rs1015160921 3867 dbSNP
rs1353102641 3870 dbSNP
rs556741734 3882 dbSNP
rs149548250 3893 dbSNP
rs1039030457 3920 dbSNP
rs544634294 3922 dbSNP
rs562778026 3924 dbSNP
rs577950529 3925 dbSNP
rs1272794530 3927 dbSNP
rs1453863158 3931 dbSNP
rs920141724 3936 dbSNP
rs1197752333 3938 dbSNP
rs1023790670 3940 dbSNP
rs1477558345 3954 dbSNP
rs574952527 3957 dbSNP
rs1249360635 3972 dbSNP
rs930331696 3983 dbSNP
rs1258845137 3985 dbSNP
rs969997703 3986 dbSNP
rs764467747 3991 dbSNP
rs886215333 3997 dbSNP
rs944442699 4006 dbSNP
rs1040096547 4007 dbSNP
rs1185939794 4014 dbSNP
rs900354887 4018 dbSNP
rs545221073 4020 dbSNP
rs995982826 4023 dbSNP
rs189305628 4024 dbSNP
rs1377715962 4039 dbSNP
rs893045110 4043 dbSNP
rs1010230922 4044 dbSNP
rs1184115842 4053 dbSNP
rs1020222733 4054 dbSNP
rs971481956 4054 dbSNP
rs528283365 4074 dbSNP
rs539988672 4080 dbSNP
rs1033181071 4087 dbSNP
rs561667503 4108 dbSNP
rs1374810218 4114 dbSNP
rs1412332773 4115 dbSNP
rs144197571 4117 dbSNP
rs550834170 4119 dbSNP
rs1333553442 4120 dbSNP
rs1287314340 4124 dbSNP
rs1034399728 4143 dbSNP
rs568787687 4146 dbSNP
rs959135422 4147 dbSNP
rs974261347 4155 dbSNP
rs532938109 4171 dbSNP
rs1386342494 4175 dbSNP
rs1160316275 4182 dbSNP
rs920215330 4193 dbSNP
rs756767534 4199 dbSNP
rs1165910232 4200 dbSNP
rs1476339370 4201 dbSNP
rs1330019027 4203 dbSNP
rs1185575994 4219 dbSNP
rs1441725883 4221 dbSNP
rs1262346597 4226 dbSNP
rs778549966 4227 dbSNP
rs1269965387 4229 dbSNP
rs1347901628 4238 dbSNP
rs541717011 4262 dbSNP
rs983145788 4276 dbSNP
rs757952892 4277 dbSNP
rs779809162 4278 dbSNP
rs1336533290 4280 dbSNP
rs1291767723 4284 dbSNP
rs1244533093 4292 dbSNP
rs907554839 4301 dbSNP
rs746736142 4303 dbSNP
rs1320844635 4310 dbSNP
rs1337791595 4312 dbSNP
rs1381080414 4312 dbSNP
rs921766988 4316 dbSNP
rs931842858 4319 dbSNP
rs566521130 4324 dbSNP
rs1162461512 4333 dbSNP
rs1040527924 4334 dbSNP
rs534415943 4344 dbSNP
rs557437812 4350 dbSNP
rs900213520 4357 dbSNP
rs1049110445 4358 dbSNP
rs878981774 4360 dbSNP
rs555963364 4361 dbSNP
rs567845594 4365 dbSNP
rs768530287 4367 dbSNP
rs545508724 4373 dbSNP
rs538569174 4376 dbSNP
rs1469485811 4379 dbSNP
rs1270888795 4387 dbSNP
rs1227455184 4399 dbSNP
rs896511162 4399 dbSNP
rs1340484119 4404 dbSNP
rs560791386 4418 dbSNP
rs1272340226 4421 dbSNP
rs1013842298 4427 dbSNP
rs1447791329 4428 dbSNP
rs1192814618 4430 dbSNP
rs1365145271 4432 dbSNP
rs1304199422 4438 dbSNP
rs1371566774 4449 dbSNP
rs1443219654 4462 dbSNP
rs1392453960 4466 dbSNP
rs201084233 4466 dbSNP
rs1478866535 4477 dbSNP
rs1045374452 4486 dbSNP
rs1396899698 4487 dbSNP
rs905323487 4487 dbSNP
rs1020129353 4500 dbSNP
rs907216303 4506 dbSNP
rs1002841882 4507 dbSNP
rs556815475 4508 dbSNP
rs1220349016 4509 dbSNP
rs1432833288 4510 dbSNP
rs868332865 4531 dbSNP
rs1034882783 4534 dbSNP
rs572533588 4536 dbSNP
rs958816184 4539 dbSNP
rs957364275 4543 dbSNP
rs182138266 4544 dbSNP
rs769783005 4545 dbSNP
rs774410835 4546 dbSNP
rs1368842614 4549 dbSNP
rs1274375303 4553 dbSNP
rs1009971919 4555 dbSNP
rs1304687903 4560 dbSNP
rs951499310 4591 dbSNP
rs1347750982 4599 dbSNP
rs185164447 4600 dbSNP
rs1174173660 4607 dbSNP
rs1262551177 4621 dbSNP
rs1486199715 4623 dbSNP
rs965724350 4624 dbSNP
rs1204631850 4630 dbSNP
rs975964194 4634 dbSNP
rs553980607 4645 dbSNP
rs1234273005 4648 dbSNP
rs1180028808 4649 dbSNP
rs766870489 4649 dbSNP
rs1482923738 4655 dbSNP
rs1258711994 4662 dbSNP
rs572175556 4673 dbSNP
rs1346379459 4676 dbSNP
rs1277942284 4694 dbSNP
rs1259859540 4696 dbSNP
rs540051270 4700 dbSNP
rs1224418853 4705 dbSNP
rs1353031199 4706 dbSNP
rs190047236 4708 dbSNP
rs1409505922 4709 dbSNP
rs1349628739 4712 dbSNP
rs1193998423 4719 dbSNP
rs985042878 4727 dbSNP
rs1326072939 4733 dbSNP
rs975764346 4735 dbSNP
rs921714463 4752 dbSNP
rs909075032 4753 dbSNP
rs767585879 4763 dbSNP
rs1364317025 4771 dbSNP
rs1156471876 4776 dbSNP
rs750099553 4793 dbSNP
rs940752640 4801 dbSNP
rs931730905 4809 dbSNP
rs1452381073 4810 dbSNP
rs1482528794 4813 dbSNP
rs555248458 4818 dbSNP
rs148300627 4820 dbSNP
rs949371892 4833 dbSNP
rs1282308764 4838 dbSNP
rs945860333 4853 dbSNP
rs1335770846 4854 dbSNP
rs1326988557 4860 dbSNP
rs1234923985 4862 dbSNP
rs1370794845 4871 dbSNP
rs1045299862 4874 dbSNP
rs1302193277 4880 dbSNP
rs755669963 4915 dbSNP
rs1346419863 4925 dbSNP
rs905458732 4930 dbSNP
rs1001014234 4936 dbSNP
rs1041618869 4939 dbSNP
rs113081346 4953 dbSNP
rs1003324531 4956 dbSNP
rs562791306 4959 dbSNP
rs757649258 4975 dbSNP
rs1187592734 4978 dbSNP
rs1476697866 4989 dbSNP
rs1246223714 4991 dbSNP
rs1208213476 4993 dbSNP
rs1469032484 4999 dbSNP
rs532797864 5001 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uaGAC---GGACUCGUAGAGGAa 5'
            |||   |||   |||||||| 
Target 5' caCUGCAACCU--CCAUCUCCUg 3'
3 - 23
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uaGAC---GGACUCGUAGAGGAa 5'
            |||   |||   |||||||| 
Target 5' caCUGCAACCU--CCAUCUCCUg 3'
4 - 24
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000341893.3 | 3UTR | CUCACUGCAACCUCCAUCUCCUGGGUUCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
110 hsa-miR-6888-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100971 CENPQ centromere protein Q 2 4
MIRT177381 WAC WW domain containing adaptor with coiled-coil 2 4
MIRT215237 NPM1 nucleophosmin 1 2 4
MIRT264969 TMEM136 transmembrane protein 136 2 2
MIRT306298 KLHL24 kelch like family member 24 2 2
MIRT319712 UBN2 ubinuclein 2 2 2
MIRT332866 TXNIP thioredoxin interacting protein 2 2
MIRT444384 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT445270 CPPED1 calcineurin like phosphoesterase domain containing 1 2 2
MIRT447185 PGRMC2 progesterone receptor membrane component 2 2 2
MIRT448763 HDX highly divergent homeobox 2 2
MIRT451468 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452754 U2AF2 U2 small nuclear RNA auxiliary factor 2 2 2
MIRT455325 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT456846 ZNF460 zinc finger protein 460 2 2
MIRT457372 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT460352 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462004 SNRNP27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 2 2
MIRT462104 TMEM214 transmembrane protein 214 2 2
MIRT465309 TRAM2 translocation associated membrane protein 2 2 2
MIRT468841 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT469635 RAD21 RAD21 cohesin complex component 2 6
MIRT470181 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT471782 NUP153 nucleoporin 153 2 2
MIRT472261 NFIC nuclear factor I C 2 2
MIRT473731 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT477728 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2 2
MIRT479358 CEP97 centrosomal protein 97 2 2
MIRT481063 BASP1 brain abundant membrane attached signal protein 1 2 2
MIRT482044 AMER1 APC membrane recruitment protein 1 2 2
MIRT482892 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT485773 B4GALT5 beta-1,4-galactosyltransferase 5 2 2
MIRT492646 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT501915 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 4
MIRT503022 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT503247 ZFP36 ZFP36 ring finger protein 2 4
MIRT504591 FAM103A1 family with sequence similarity 103 member A1 2 6
MIRT507346 FAM168A family with sequence similarity 168 member A 2 2
MIRT508274 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT508414 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508956 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT514698 SOD2 superoxide dismutase 2 2 2
MIRT515837 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 4
MIRT516095 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT516420 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT516863 TYW5 tRNA-yW synthesizing protein 5 2 2
MIRT516940 MRRF mitochondrial ribosome recycling factor 2 2
MIRT518122 RNMTL1 mitochondrial rRNA methyltransferase 3 2 4
MIRT522745 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT523816 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT524107 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT526722 RPS9 ribosomal protein S9 2 2
MIRT527047 ISY1-RAB43 ISY1-RAB43 readthrough 2 2
MIRT534174 SLC8A1 solute carrier family 8 member A1 2 2
MIRT537151 GJA1 gap junction protein alpha 1 2 2
MIRT544174 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT544558 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT544569 POLDIP3 DNA polymerase delta interacting protein 3 2 2
MIRT545174 SPATA18 spermatogenesis associated 18 2 2
MIRT545478 TRIM37 tripartite motif containing 37 2 2
MIRT549771 ZNF611 zinc finger protein 611 2 4
MIRT550733 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550864 SNAP47 synaptosome associated protein 47 2 4
MIRT551297 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551325 GSG2 histone H3 associated protein kinase 2 6
MIRT552807 XIAP X-linked inhibitor of apoptosis 2 4
MIRT555345 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 4
MIRT558137 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT560877 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT561906 SMCR7L mitochondrial elongation factor 1 1 1
MIRT564414 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT568716 TMEM30B transmembrane protein 30B 2 2
MIRT573284 NCAPH non-SMC condensin I complex subunit H 2 2
MIRT573685 HES6 hes family bHLH transcription factor 6 2 2
MIRT618161 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT622840 PDZD4 PDZ domain containing 4 2 2
MIRT624355 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT642273 SMIM17 small integral membrane protein 17 2 2
MIRT652967 SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2 2
MIRT666642 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT680851 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681368 BRI3BP BRI3 binding protein 2 2
MIRT681551 ZNF738 zinc finger protein 738 2 2
MIRT681667 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681808 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681955 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682192 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682249 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682396 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT685160 DTWD2 DTW domain containing 2 2 2
MIRT687030 RNF24 ring finger protein 24 2 2
MIRT688377 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT690383 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT691949 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT693036 MB21D1 Mab-21 domain containing 1 2 2
MIRT693110 SCNM1 sodium channel modifier 1 2 2
MIRT694481 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT694898 ZNF417 zinc finger protein 417 2 2
MIRT696667 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT698663 TERF2 telomeric repeat binding factor 2 2 2
MIRT700157 RNF115 ring finger protein 115 2 2
MIRT700984 PDE4D phosphodiesterase 4D 2 2
MIRT702139 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT702207 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702496 KIAA1328 KIAA1328 2 2
MIRT704932 CCDC36 coiled-coil domain containing 36 2 2
MIRT705778 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT707795 TTYH3 tweety family member 3 2 2
MIRT711479 MYH15 myosin heavy chain 15 2 2
MIRT713188 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6888-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6888-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)

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