pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol CD81   
Synonyms CVID6, S5.7, TAPA1, TSPAN28
Description CD81 molecule
Transcript NM_004356   
Expression
Putative miRNA Targets on CD81
3'UTR of CD81
(miRNA target sites are highlighted)
>CD81|NM_004356|3'UTR
   1 GGCCCCGCAGCTCTGGCCACAGGGACCTCTGCAGTGCCCCCTAAGTGACCCGGACACTTCCGAGGGGGCCATCACCGCCT
  81 GTGTATATAACGTTTCCGGTATTACTCTGCTACACGTAGCCTTTTTACTTTTGGGGTTTTGTTTTTGTTCTGAACTTTCC
 161 TGTTACCTTTTCAGGGCTGACGTCACATGTAGGTGGCGTGTATGAGTGGAGACGGGCCTGGGTCTTGGGGACTGGAGGGC
 241 AGGGGTCCTTCTGCCCTGGGGTCCCAGGGTGCTCTGCCTGCTCAGCCAGGCCTCTCCTGGGAGCCACTCGCCCAGAGACT
 321 CAGCTTGGCCAACTTGGGGGGCTGTGTCCACCCAGCCCGCCCGTCCTGTGGGCTGCACAGCTCACCTTGTTCCCTCCTGC
 401 CCCGGTTCGAGAGCCGAGTCTGTGGGCACTCTCTGCCTTCATGCACCTGTCCTTTCTAACACGTCGCCTTCAACTGTAAT
 481 CACAACATCCTGACTCCGTCATTTAATAAAGAAGGAACATCAGGCATGCTACCAGGCCTGTGCAGTCCCTCAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agauUUAGAGUAUCACGGAAGa 5'
              | ||||    ||||||| 
Target 5' gggcACTCTC----TGCCTTCa 3'
424 - 441 148.00 -11.40
2
miRNA  3' agauuuAGAGUAU-CA-CGGAAGa 5'
                ||| | | || |||||| 
Target 5' gtccttTCTAACACGTCGCCTTCa 3'
449 - 472 124.00 -9.00
3
miRNA  3' agAUUU-AGAGUAUCACGGAAGa 5'
            |:|| |:|| |: | ||||: 
Target 5' tcTGAACTTTCCTGTTACCTTTt 3'
149 - 171 116.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30454747 52 COSMIC
COSN26969920 53 COSMIC
COSN30498339 63 COSMIC
COSN20077370 71 COSMIC
COSN23655933 72 COSMIC
COSN30498128 101 COSMIC
COSN31526348 114 COSMIC
COSN24091553 364 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs774235346 2 dbSNP
rs1427506647 4 dbSNP
rs1417603458 5 dbSNP
rs948467244 6 dbSNP
rs188175983 7 dbSNP
rs368448552 8 dbSNP
rs755687318 9 dbSNP
rs1301767029 11 dbSNP
rs1365568283 12 dbSNP
rs765716594 13 dbSNP
rs1200811527 14 dbSNP
rs1451121769 16 dbSNP
rs753248682 23 dbSNP
rs1430743393 25 dbSNP
rs750214924 25 dbSNP
rs758755980 27 dbSNP
rs1389270135 28 dbSNP
rs1187893511 30 dbSNP
rs755947408 33 dbSNP
rs777957535 34 dbSNP
rs1241766781 36 dbSNP
rs747416444 38 dbSNP
rs757357708 40 dbSNP
rs779737723 40 dbSNP
rs10645 41 dbSNP
rs746329414 42 dbSNP
rs754474454 42 dbSNP
rs778297508 42 dbSNP
rs745930267 44 dbSNP
rs770043232 46 dbSNP
rs1206254690 50 dbSNP
rs775538716 52 dbSNP
rs748078366 53 dbSNP
rs911957710 54 dbSNP
rs1412830763 56 dbSNP
rs1340542723 57 dbSNP
rs1312238606 62 dbSNP
rs566859282 63 dbSNP
rs947280364 65 dbSNP
rs974738375 66 dbSNP
rs1039021328 69 dbSNP
rs1431366945 69 dbSNP
rs900539408 77 dbSNP
rs35800690 78 dbSNP
rs1458408410 84 dbSNP
rs1370125582 85 dbSNP
rs920586136 86 dbSNP
rs997454117 87 dbSNP
rs1239350293 88 dbSNP
rs74701050 92 dbSNP
rs1183219183 93 dbSNP
rs1484232153 96 dbSNP
rs1063316 98 dbSNP
rs1195588730 98 dbSNP
rs1210795616 99 dbSNP
rs886717708 107 dbSNP
rs950166251 112 dbSNP
rs1005470873 115 dbSNP
rs1354312291 116 dbSNP
rs1804493 117 dbSNP
rs963984605 121 dbSNP
rs1327861365 129 dbSNP
rs1348393882 129 dbSNP
rs905570764 132 dbSNP
rs1161426886 133 dbSNP
rs1459915143 135 dbSNP
rs1486948598 138 dbSNP
rs1175487757 148 dbSNP
rs1249948286 154 dbSNP
rs1001698574 155 dbSNP
rs1419842955 159 dbSNP
rs530580827 160 dbSNP
rs1365291795 161 dbSNP
rs113585763 165 dbSNP
rs1432698291 167 dbSNP
rs1268288819 168 dbSNP
rs892792063 178 dbSNP
rs1023882418 179 dbSNP
rs1375924788 182 dbSNP
rs955309220 183 dbSNP
rs1295901929 187 dbSNP
rs1440161092 189 dbSNP
rs986556099 198 dbSNP
rs749149940 199 dbSNP
rs143793173 201 dbSNP
rs1391583815 203 dbSNP
rs1308782797 210 dbSNP
rs1158252242 211 dbSNP
rs1369223718 214 dbSNP
rs928409359 215 dbSNP
rs975227943 220 dbSNP
rs1281500914 225 dbSNP
rs770452088 226 dbSNP
rs1049390 242 dbSNP
rs914380499 245 dbSNP
rs34939011 254 dbSNP
rs947206931 262 dbSNP
rs1210004076 266 dbSNP
rs1038951256 267 dbSNP
rs1444815321 270 dbSNP
rs1481021846 273 dbSNP
rs1283084045 274 dbSNP
rs1219500302 275 dbSNP
rs952010149 281 dbSNP
rs900424917 286 dbSNP
rs1251429331 293 dbSNP
rs1233304146 297 dbSNP
rs535211091 310 dbSNP
rs1454002635 311 dbSNP
rs908103201 323 dbSNP
rs933356773 328 dbSNP
rs1395486726 332 dbSNP
rs1051734494 333 dbSNP
rs1415327479 334 dbSNP
rs1049549 335 dbSNP
rs1353411824 336 dbSNP
rs1454125469 336 dbSNP
rs763029467 336 dbSNP
rs1191102395 337 dbSNP
rs568706017 342 dbSNP
rs1016858211 354 dbSNP
rs1474129850 355 dbSNP
rs927447082 358 dbSNP
rs899362364 359 dbSNP
rs535797531 360 dbSNP
rs767130888 361 dbSNP
rs557272729 363 dbSNP
rs1299398239 364 dbSNP
rs892915391 367 dbSNP
rs1023934673 369 dbSNP
rs1391744419 376 dbSNP
rs1439746294 385 dbSNP
rs1359948825 390 dbSNP
rs775196913 404 dbSNP
rs1373708133 407 dbSNP
rs575239537 409 dbSNP
rs1035338452 410 dbSNP
rs955993856 417 dbSNP
rs891008045 418 dbSNP
rs1008090176 419 dbSNP
rs1295576864 424 dbSNP
rs1308136288 431 dbSNP
rs1018228945 432 dbSNP
rs1419437905 434 dbSNP
rs988604325 437 dbSNP
rs1473509549 442 dbSNP
rs762386257 445 dbSNP
rs1186843322 447 dbSNP
rs770313718 452 dbSNP
rs995379058 452 dbSNP
rs1049648 457 dbSNP
rs138604169 459 dbSNP
rs1049652 463 dbSNP
rs183619205 464 dbSNP
rs750711443 466 dbSNP
rs1049659 467 dbSNP
rs907885191 468 dbSNP
rs933199989 474 dbSNP
rs1354420861 480 dbSNP
rs1184695753 482 dbSNP
rs971422598 484 dbSNP
rs1406576647 485 dbSNP
rs1415095732 498 dbSNP
rs541203101 499 dbSNP
rs559300491 527 dbSNP
rs1418636325 531 dbSNP
rs1052218780 532 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauuuAGAGUAU-CA-CGGAAGa 5'
                ||| | | || |||||| 
Target 5' -uccuuUCUAACACGUCGCCUUCa 3'
1 - 23
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000263645.5 | 3UTR | UCCUUUCUAACACGUCGCCUUCAACUGUAAUCACAACAUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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