miRTarBase - #MIRT479897


—
pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol CCDC117   
Synonyms dJ366L4.1
Description coiled-coil domain containing 117
Transcript NM_173510   
Expression
Putative miRNA Targets on CCDC117
3'UTR of CCDC117
(miRNA target sites are highlighted)		 
>CCDC117|NM_173510|3'UTR
   1 AAACCAATTTCTACACTAAAGTTGTCAAATGTTAGAAGAATCCTGTGTTCAGTTATGAGACTCTTTGCATAGTATAGGGA
  81 CTTGAAAGTTTTATGAGACGGGTGTAATAATATCTCCACCTGTGATTTGGGGGTGGGACTCTTATTTTGGGTAGCCATTT
 161 ATTGACTTCACCTTTTTGCCAAGGACGTTTGTCTCAAGGGAAAAGCAGTTTTCTGTGGGGCTTATTAAAGGAATGTTGGT
 241 TTACATTGTCTTCAAAGACAAGTATAGAAGCTGTATGTGTAAGGGTGACTTAAATCATATGTCACATTGTCTAAACTATT
 321 CAGACACTTGGAGAATATTCTCCTTGAATTAAAAAAGATGATTAAGAAGGATGCTCCTACAACTGTATCCTGACAGTTAA
 401 GTCACAGCTTAATGTGTAGATATGAGCTGTTTACAGTGGTGACTATATATAATTGGGGAGAAGAAGGGAAGAGAGCAGCA
 481 GTAGCTTAAGCCTGTTGCTAAGAAATTTAATTTCTTAGCAACTTGTAATTTAGTTATCAATTCAATATAGCTCTGTTGAT
 561 TAAATAGCCGATAGTATTGTGGCTCTCCTCTTTGACTATGAAAATATAGAGAAAGTTTTTTCTTTAAGGCTTTTTTGCCT
 641 TGTGCCACTGTTGCTCCTTGGTTTCCCTTGCGTAATTGATAAGCCCAGTTATTCAGTAATGTTTACAAATTAATTGACTT
 721 TGATAGTTAAAAGATTATGAGGTAACCCATCTGCAATTTGCCTGTGGGAGAAGCATCCTTTAGTTCATCTTAAGGAAGTG
 801 CTTTATCAGCTAAACCCAACATTGATAACTTTGGTAATTTTTTTAAAAAGTTATACTTGTATTAGCAAGTTTTTTTTTTT
 881 TTCCCCCACCGCAACCTCCATCTCCCGGGTTCAAGCAATTCTCCTGCCTCACCCTCCCAAGTAGCTGGGATTACAGGTGC
 961 CCACCTCCACGCCCAGCTAATTTTTGTATTTTTAATAGAGACCGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCT
1041 GACCTCAGGTGATCTGCCCACCCCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACGGCACGCAGCCAGCAAGTT
1121 GTTTTTAAATGTTAATATAGAAAACAGTGAAGGATTAGCTGAAAATATATGAGCAGGTGACATTGAGGTTTACTGAAATA
1201 GCCAATTTGACTGGTGCTTAGACTATTGTGCAGTAAACCTAAAAGGTAGTGGAGAATTGCTTCCTGCTAGCAGGAAGCCT
1281 TCATCTTCTTGAGTACCCAAACCAGGCTTCAGGTGTCCTTTGAGGATAGCCAGGTTTGAAATTTTTAGTTTCTCAGGAAG
1361 AGCTCTTCTATGTGGCAGGGGCTGATAGGGCAAAATAAAATGACAATTTCTTTATTGCTACAGAGTATCCTCTATAAGTT
1441 ATTAAACGAGTGTAATGGTATAATGCCCTTCCATCACACAACAGGACACCACCCCAGTTTTGTTTTCTGGGTTTCTTCCC
1521 CCTTTGTAGGAATCAGATACCTTTTGTAGAAAAAAATGGCTTATGCCACGTAAAGGTGAATTTTTAGAAACCACCTTCTA
1601 GGCGTTTTTGGAACCCTTACTGAAATCCCTCCCCTTGTTACAGATGGCGTAGAAGTCACAAGTCTGTTAATTGGACTGTT
1681 GCTTCTTTGCCTGTTCCTGCTTTCTCTTTCTGTCTGGATAGTCAGGAAAAGATTTAATGTTTAATATTTAAACAAAATAT
1761 TTAATGTCTATACAGTAAAATTATTCAAACTTCAAACCAGTATTGAAAGCAGTTGGAAACCAGCTAATAGTTTCTTAATC
1841 TCAGATTTCGAGATGAATGTAAACTGTATTCTTTTGAAATGTGCAAGTGTTTGATTCATGCCATTTGATAAACTTCTGCC
1921 TTGTAGTCATTGTTTGATGGGACCAACTTGTAAAGTATGAGCCTTAAATAAATCTCCATGCTGAAAAATGTGTTCTAATG
2001 CAACACAAAAACATGAAGTGACTGCCCAGAGGTAGAGTTAGTGTTTAGGTGGAAAGGGAGATGACAGCTTTCCAAAGAAG
2081 GACCTAAAACACACCAAGATTGTCTTCTACAGGAATTGCTGGGCAGGTCTCCGACTAAAGGTCTTATGATGAAAAGGAAG
2161 AAACAAGCCCCCAACACAAGGCTCTGATACTACTGGTAAATGTAGGAGAGAATTAAGAATCTGTTAATTAAAATCCAAAC
2241 AGAGCTTATTTCAGTAGTCAAGTTACCTGACATGATAATTATTTCTGCAGGATAATTGATGTTTTATGTTCTTTTTTGGA
2321 CTTTATCTTCTTGCAAAAATTTCTACAAAAATTGTTTTCTTCATCCTTGTGGTGCTTATTCATCTGAGCCGTCTCCACAG
2401 TCCCAATGCCTCTGCTTTTTGTTTTACTTTTGTAGCATAAGGTTTTTGCTTTTGCTTTGCCTTAAGAGTTCCCTAGGGAG
2481 TTACCAGGGCTTTTCGTTTTGTGTAGCTTTTGCAGCATGGATCAAACATTGGCTTACTGTGCTAATGTGTGAAGAGAAAA
2561 AATTCTCTAAAGCAGGTGAGCTTTAATGAACAAATGTGTATTTTATCTGAGTTTGAGTAGGGTGCGTTGTGGATTTTGTT
2641 TTTTGGGTTTTTTTTTTTTTTTTGTAATTATATGAAGAAAGTCCAGTTCTCATAAATATTGATCACTTAAAAAACTTACT
2721 CTTTCTTGAAAAGGTACACATGTAAAATTTAGGAAAATAACTAAAGTAGGGGCTGGAACCATAAGAAGAATGTTTATCAG
2801 CACGTTCATTTATTATTTTGGATTTGGAACTTGGCTTTGTTTTTCAATAGTGACAAGAATGGTTCAGTTCTAGGAATGTT
2881 CTGGAAGATGCTGTTAATTTTACTTTAAAATGAGAATCTGGTGTTACTGTATTTTATCGTTTTCAATAAAACTTCTTAAG
2961 TGTTTTGGACTTTTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augCGGUCAGUUAUGGAACACu 5'
             ||:  |:  |:||||||| 
Target 5' aagGCT--TTTTTGCCTTGTGc 3'
 626 - 645 147.00 -12.90
2 
miRNA  3' augcggucAGUUAUGGAACACu 5'
                  |: || ||||||| 
Target 5' ttgttttcTTCAT-CCTTGTGg 3'
 2352 - 2372 145.00 -12.40
3 
miRNA  3' auGCGGUCAGUUAU--------GGAACAcu 5'
            :|||| |::|||        ||||||  
Target 5' caTGCCATTTGATAAACTTCTGCCTTGTag 3'
 1897 - 1926 138.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM9526062 1 COSMIC
COSN31527395 44 COSMIC
COSN30149808 56 COSMIC
COSN30175528 58 COSMIC
COSN30480722 96 COSMIC
COSN13908426 100 COSMIC
COSN28677152 187 COSMIC
COSN30532706 208 COSMIC
COSN30172405 464 COSMIC
COSN31591647 495 COSMIC
COSN31538666 679 COSMIC
COSN31486429 740 COSMIC
COSN26664743 743 COSMIC
COSN26555547 754 COSMIC
COSN28715700 820 COSMIC
COSN1260496 883 COSMIC
COSN28947087 883 COSMIC
COSN26577483 1349 COSMIC
COSN31529472 1588 COSMIC
COSN20839438 1699 COSMIC
COSN31541377 1700 COSMIC
COSN31515825 1732 COSMIC
COSN31609689 1762 COSMIC
COSN31529177 1769 COSMIC
COSN26584248 1851 COSMIC
COSN31607170 1898 COSMIC
COSN1260497 1969 COSMIC
COSN31535055 2211 COSMIC
COSN22886469 2275 COSMIC
COSN5990589 2324 COSMIC
COSN15689473 2326 COSMIC
COSN26564494 2370 COSMIC
COSN30541621 2507 COSMIC
COSN31537724 2626 COSMIC
COSN18760027 2664 COSMIC
COSN20117329 2664 COSMIC
COSN27214367 2664 COSMIC
COSN1260498 2667 COSMIC
COSN30543822 2684 COSMIC
COSN31567845 2715 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1288279753 7 dbSNP
rs377126733 8 dbSNP
rs745396819 10 dbSNP
rs751223225 14 dbSNP
rs775139472 16 dbSNP
rs1188075602 17 dbSNP
rs763044376 18 dbSNP
rs768694822 19 dbSNP
rs1414031045 21 dbSNP
rs370581950 23 dbSNP
rs774229679 29 dbSNP
rs1019412606 30 dbSNP
rs1204687835 31 dbSNP
rs761463911 31 dbSNP
rs766633062 32 dbSNP
rs753936751 43 dbSNP
rs1271250233 44 dbSNP
rs372804266 48 dbSNP
rs1335275917 58 dbSNP
rs563450116 62 dbSNP
rs1222297300 64 dbSNP
rs1372611445 64 dbSNP
rs1346856549 67 dbSNP
rs1420100828 69 dbSNP
rs1449160054 70 dbSNP
rs1297289276 72 dbSNP
rs575148934 76 dbSNP
rs1325872084 80 dbSNP
rs1462256700 92 dbSNP
rs189905230 95 dbSNP
rs908788515 100 dbSNP
rs745406977 101 dbSNP
rs1406870644 114 dbSNP
rs774278635 121 dbSNP
rs1046533517 129 dbSNP
rs1213019233 129 dbSNP
rs1468709182 129 dbSNP
rs932034692 131 dbSNP
rs1367056643 139 dbSNP
rs1050462867 140 dbSNP
rs1308034143 142 dbSNP
rs1242365403 144 dbSNP
rs769663128 146 dbSNP
rs563797090 150 dbSNP
rs1442299587 151 dbSNP
rs938069705 155 dbSNP
rs779973566 157 dbSNP
rs1287473694 158 dbSNP
rs1053810164 180 dbSNP
rs5762795 187 dbSNP
rs1420937495 188 dbSNP
rs1011500216 207 dbSNP
rs1192862547 216 dbSNP
rs1042060764 217 dbSNP
rs1269442144 219 dbSNP
rs768496559 220 dbSNP
rs943860470 221 dbSNP
rs1219097910 223 dbSNP
rs903098864 235 dbSNP
rs1040979633 238 dbSNP
rs74349591 240 dbSNP
rs1235194413 246 dbSNP
rs1333312247 265 dbSNP
rs559873305 266 dbSNP
rs1363122799 274 dbSNP
rs993850717 274 dbSNP
rs1298368934 290 dbSNP
rs1027030278 313 dbSNP
rs1490939467 333 dbSNP
rs1373315339 337 dbSNP
rs1223382884 341 dbSNP
rs1246900424 343 dbSNP
rs773399757 349 dbSNP
rs1487892689 352 dbSNP
rs138605810 357 dbSNP
rs1168272043 359 dbSNP
rs1410081000 360 dbSNP
rs756410442 364 dbSNP
rs1019443684 372 dbSNP
rs1196031493 375 dbSNP
rs899595250 380 dbSNP
rs73881144 383 dbSNP
rs1378312926 386 dbSNP
rs45544841 390 dbSNP
rs1347259572 393 dbSNP
rs1250077743 404 dbSNP
rs115257029 410 dbSNP
rs1318961581 418 dbSNP
rs578148451 418 dbSNP
rs1413380886 424 dbSNP
rs1434420717 426 dbSNP
rs982467655 428 dbSNP
rs967996100 430 dbSNP
rs771701797 443 dbSNP
rs1016285085 444 dbSNP
rs978794013 446 dbSNP
rs1377741721 450 dbSNP
rs970941525 451 dbSNP
rs1446772287 459 dbSNP
rs1424327838 461 dbSNP
rs1307684197 463 dbSNP
rs982260403 467 dbSNP
rs953377133 469 dbSNP
rs1474126225 471 dbSNP
rs1417370729 479 dbSNP
rs56119508 482 dbSNP
rs1444148352 491 dbSNP
rs1248518003 492 dbSNP
rs1195372675 495 dbSNP
rs1458598783 496 dbSNP
rs1260596869 497 dbSNP
rs911948163 499 dbSNP
rs943903300 505 dbSNP
rs1283186324 509 dbSNP
rs1041237427 520 dbSNP
rs1341667518 528 dbSNP
rs776520427 540 dbSNP
rs552597871 546 dbSNP
rs915320891 548 dbSNP
rs1400905608 552 dbSNP
rs1333322514 554 dbSNP
rs180700061 555 dbSNP
rs753316423 561 dbSNP
rs535101708 562 dbSNP
rs185313500 569 dbSNP
rs146621007 570 dbSNP
rs763391087 571 dbSNP
rs1163573334 579 dbSNP
rs1413353495 581 dbSNP
rs899626346 583 dbSNP
rs996686747 586 dbSNP
rs1403879371 588 dbSNP
rs764597618 596 dbSNP
rs1401187496 597 dbSNP
rs888186804 598 dbSNP
rs1212074817 600 dbSNP
rs1358011091 608 dbSNP
rs1277452089 625 dbSNP
rs1238741708 630 dbSNP
rs1014428983 638 dbSNP
rs1329951186 639 dbSNP
rs1385560395 649 dbSNP
rs1330520284 657 dbSNP
rs1323958708 670 dbSNP
rs1449236899 672 dbSNP
rs1004316675 673 dbSNP
rs574540888 685 dbSNP
rs61257487 686 dbSNP
rs1382258157 688 dbSNP
rs1192232124 705 dbSNP
rs756811144 709 dbSNP
rs1454216377 711 dbSNP
rs1226313013 737 dbSNP
rs982290064 739 dbSNP
rs557174195 743 dbSNP
rs780911922 747 dbSNP
rs73881146 757 dbSNP
rs989660764 761 dbSNP
rs1281639511 764 dbSNP
rs1197412574 776 dbSNP
rs544901862 778 dbSNP
rs1287539921 780 dbSNP
rs545731676 787 dbSNP
rs369615243 789 dbSNP
rs1231521016 794 dbSNP
rs1344194416 794 dbSNP
rs1444002187 796 dbSNP
rs945466672 800 dbSNP
rs1188160752 802 dbSNP
rs1275403814 804 dbSNP
rs953391757 806 dbSNP
rs1324486862 817 dbSNP
rs1236744491 818 dbSNP
rs6005881 820 dbSNP
rs1196174353 824 dbSNP
rs1171831112 827 dbSNP
rs911871525 833 dbSNP
rs966490596 838 dbSNP
rs972164378 840 dbSNP
rs943936397 845 dbSNP
rs1241898607 846 dbSNP
rs1040946493 851 dbSNP
rs371525923 851 dbSNP
rs929806359 851 dbSNP
rs1488407487 855 dbSNP
rs899750488 861 dbSNP
rs1048372888 870 dbSNP
rs1277325720 870 dbSNP
rs1279175670 870 dbSNP
rs201981028 870 dbSNP
rs909773815 873 dbSNP
rs1415606022 875 dbSNP
rs1342586264 877 dbSNP
rs1334067313 882 dbSNP
rs1055431133 883 dbSNP
rs572531353 883 dbSNP
rs1357833493 884 dbSNP
rs1433284896 886 dbSNP
rs1423623179 888 dbSNP
rs932502197 891 dbSNP
rs1425270988 892 dbSNP
rs1340695582 899 dbSNP
rs540305674 901 dbSNP
rs1185370136 907 dbSNP
rs1482609878 908 dbSNP
rs1048213183 916 dbSNP
rs888207307 919 dbSNP
rs1275833072 936 dbSNP
rs1257398623 937 dbSNP
rs1346490875 954 dbSNP
rs1041466590 955 dbSNP
rs1003943422 958 dbSNP
rs1291606687 961 dbSNP
rs1227967207 964 dbSNP
rs903374005 969 dbSNP
rs1440180358 971 dbSNP
rs1036659166 972 dbSNP
rs561654428 975 dbSNP
rs1033241909 978 dbSNP
rs1392750845 980 dbSNP
rs1422871769 981 dbSNP
rs1414141966 983 dbSNP
rs1003154328 987 dbSNP
rs1183072429 989 dbSNP
rs376025458 992 dbSNP
rs1237450331 998 dbSNP
rs369157524 1000 dbSNP
rs1458873049 1001 dbSNP
rs548508873 1004 dbSNP
rs1322534198 1005 dbSNP
rs1292343446 1017 dbSNP
rs372619277 1020 dbSNP
rs959629575 1025 dbSNP
rs1018934179 1029 dbSNP
rs563949472 1033 dbSNP
rs1477582420 1034 dbSNP
rs1191770172 1038 dbSNP
rs1369511366 1047 dbSNP
rs972581044 1048 dbSNP
rs530396348 1052 dbSNP
rs1026384205 1061 dbSNP
rs1478382885 1080 dbSNP
rs1166512823 1081 dbSNP
rs190021182 1084 dbSNP
rs375670329 1089 dbSNP
rs371153753 1093 dbSNP
rs181893486 1094 dbSNP
rs983932960 1096 dbSNP
rs1441453839 1099 dbSNP
rs866717588 1102 dbSNP
rs911901271 1103 dbSNP
rs766558892 1107 dbSNP
rs937209556 1108 dbSNP
rs1248626161 1112 dbSNP
rs528511156 1116 dbSNP
rs76014083 1119 dbSNP
rs1286817380 1123 dbSNP
rs1242474886 1135 dbSNP
rs755685363 1136 dbSNP
rs187607475 1138 dbSNP
rs535594956 1139 dbSNP
rs974725551 1140 dbSNP
rs949730653 1146 dbSNP
rs1387666569 1149 dbSNP
rs774526950 1169 dbSNP
rs537748297 1172 dbSNP
rs902908384 1175 dbSNP
rs1158699787 1184 dbSNP
rs1360284923 1185 dbSNP
rs143734783 1191 dbSNP
rs1399073615 1195 dbSNP
rs1048723350 1196 dbSNP
rs374604900 1204 dbSNP
rs1332360707 1205 dbSNP
rs939774399 1206 dbSNP
rs1264234686 1213 dbSNP
rs1218849153 1217 dbSNP
rs1274208782 1222 dbSNP
rs1036776564 1224 dbSNP
rs906289291 1226 dbSNP
rs1242061377 1248 dbSNP
rs539323918 1259 dbSNP
rs1255870151 1260 dbSNP
rs1234611253 1264 dbSNP
rs1003185609 1267 dbSNP
rs1314533954 1273 dbSNP
rs1054705757 1278 dbSNP
rs895400320 1280 dbSNP
rs1218459693 1287 dbSNP
rs767596588 1298 dbSNP
rs557661552 1304 dbSNP
rs749271279 1308 dbSNP
rs993486034 1313 dbSNP
rs377432537 1314 dbSNP
rs1022886961 1339 dbSNP
rs966867334 1349 dbSNP
rs1401243891 1353 dbSNP
rs1214779989 1354 dbSNP
rs1302128318 1355 dbSNP
rs1466487761 1358 dbSNP
rs1026835484 1363 dbSNP
rs1168247019 1371 dbSNP
rs1477397054 1381 dbSNP
rs1424557897 1384 dbSNP
rs952127028 1386 dbSNP
rs983965529 1389 dbSNP
rs1255554521 1391 dbSNP
rs112000931 1401 dbSNP
rs191500643 1404 dbSNP
rs1256757691 1407 dbSNP
rs958524855 1408 dbSNP
rs1019065047 1413 dbSNP
rs991429476 1416 dbSNP
rs917161384 1419 dbSNP
rs1220098700 1420 dbSNP
rs1159769604 1423 dbSNP
rs1338408995 1424 dbSNP
rs1311376987 1432 dbSNP
rs966107121 1433 dbSNP
rs183764746 1435 dbSNP
rs1329268118 1443 dbSNP
rs924363647 1448 dbSNP
rs778528436 1449 dbSNP
rs1172638612 1456 dbSNP
rs1156479612 1457 dbSNP
rs1392375079 1471 dbSNP
rs555403692 1476 dbSNP
rs747994085 1482 dbSNP
rs954101946 1483 dbSNP
rs1448976382 1484 dbSNP
rs764612293 1486 dbSNP
rs1352762199 1489 dbSNP
rs1236831292 1490 dbSNP
rs1178579162 1494 dbSNP
rs1458440733 1506 dbSNP
rs889303851 1509 dbSNP
rs770997880 1518 dbSNP
rs943526155 1534 dbSNP
rs868595356 1536 dbSNP
rs114517072 1541 dbSNP
rs573646662 1547 dbSNP
rs1306919105 1549 dbSNP
rs544342861 1551 dbSNP
rs370852937 1557 dbSNP
rs1047693081 1558 dbSNP
rs927745697 1563 dbSNP
rs1390233902 1567 dbSNP
rs187857890 1570 dbSNP
rs754199505 1571 dbSNP
rs1006350129 1583 dbSNP
rs1158200592 1586 dbSNP
rs1240629477 1588 dbSNP
rs1197164976 1595 dbSNP
rs1451427596 1596 dbSNP
rs745932261 1601 dbSNP
rs958558875 1604 dbSNP
rs531165445 1605 dbSNP
rs148947113 1607 dbSNP
rs1354289211 1612 dbSNP
rs1438254016 1614 dbSNP
rs16986709 1620 dbSNP
rs1369846105 1621 dbSNP
rs1458158413 1626 dbSNP
rs971303949 1628 dbSNP
rs528438521 1631 dbSNP
rs1297637742 1635 dbSNP
rs1420431246 1638 dbSNP
rs902747446 1645 dbSNP
rs1466700870 1649 dbSNP
rs924340378 1650 dbSNP
rs557650790 1654 dbSNP
rs1490731930 1659 dbSNP
rs1260641731 1660 dbSNP
rs1215209515 1673 dbSNP
rs1375994647 1679 dbSNP
rs776113014 1683 dbSNP
rs989885102 1691 dbSNP
rs910271441 1696 dbSNP
rs745499002 1702 dbSNP
rs1225173978 1705 dbSNP
rs1338673579 1705 dbSNP
rs568481009 1707 dbSNP
rs1347054587 1709 dbSNP
rs1400640507 1709 dbSNP
rs1332695566 1716 dbSNP
rs1414397971 1720 dbSNP
rs901948615 1731 dbSNP
rs1403602137 1734 dbSNP
rs559680833 1752 dbSNP
rs1174644752 1758 dbSNP
rs1477063221 1762 dbSNP
rs1420959020 1771 dbSNP
rs1192494741 1776 dbSNP
rs758069146 1789 dbSNP
rs923529349 1798 dbSNP
rs1029416554 1799 dbSNP
rs1320135631 1807 dbSNP
rs763518352 1812 dbSNP
rs929611082 1814 dbSNP
rs1199299837 1821 dbSNP
rs532083533 1828 dbSNP
rs1279298876 1832 dbSNP
rs952114648 1835 dbSNP
rs1205288292 1836 dbSNP
rs1315864236 1839 dbSNP
rs1038402116 1840 dbSNP
rs1364433068 1845 dbSNP
rs1456777239 1846 dbSNP
rs41281605 1850 dbSNP
rs551079454 1851 dbSNP
rs1339292620 1855 dbSNP
rs1464338540 1865 dbSNP
rs1400029584 1867 dbSNP
rs1055228768 1869 dbSNP
rs1186444966 1871 dbSNP
rs746481311 1872 dbSNP
rs895191606 1875 dbSNP
rs961262938 1891 dbSNP
rs1179580156 1896 dbSNP
rs866492003 1898 dbSNP
rs1237939446 1904 dbSNP
rs1478528146 1913 dbSNP
rs1456229792 1917 dbSNP
rs1199101815 1930 dbSNP
rs1257186756 1930 dbSNP
rs568694373 1932 dbSNP
rs998804574 1938 dbSNP
rs762244050 1939 dbSNP
rs539261515 1944 dbSNP
rs557586018 1945 dbSNP
rs566441580 1950 dbSNP
rs868582487 1957 dbSNP
rs1399460976 1958 dbSNP
rs1043772066 1965 dbSNP
rs534138464 1973 dbSNP
rs1332430926 1975 dbSNP
rs902782699 1977 dbSNP
rs910307468 1982 dbSNP
rs878974353 1993 dbSNP
rs74811137 1999 dbSNP
rs1404187596 2004 dbSNP
rs573610697 2006 dbSNP
rs1040567238 2021 dbSNP
rs1385319375 2025 dbSNP
rs543957969 2029 dbSNP
rs996338895 2047 dbSNP
rs976231224 2048 dbSNP
rs1237546822 2049 dbSNP
rs1177528162 2053 dbSNP
rs1481505769 2054 dbSNP
rs1029118996 2056 dbSNP
rs923505361 2058 dbSNP
rs1221116627 2064 dbSNP
rs1322620410 2069 dbSNP
rs1294022072 2071 dbSNP
rs1238114869 2083 dbSNP
rs1291692197 2088 dbSNP
rs1225786433 2089 dbSNP
rs1365948291 2090 dbSNP
rs1435305285 2091 dbSNP
rs151025039 2096 dbSNP
rs1365872953 2111 dbSNP
rs887840103 2114 dbSNP
rs1304408447 2125 dbSNP
rs1417354465 2128 dbSNP
rs1342548759 2130 dbSNP
rs1159758883 2133 dbSNP
rs191467805 2134 dbSNP
rs1422791473 2138 dbSNP
rs1190462372 2141 dbSNP
rs1490567418 2148 dbSNP
rs1048004633 2150 dbSNP
rs1271367463 2163 dbSNP
rs1006249361 2165 dbSNP
rs1219333991 2166 dbSNP
rs1015310978 2170 dbSNP
rs1287298541 2172 dbSNP
rs1218567216 2181 dbSNP
rs961293765 2185 dbSNP
rs1311027061 2191 dbSNP
rs972583582 2193 dbSNP
rs767074790 2194 dbSNP
rs1055094982 2197 dbSNP
rs1284828345 2217 dbSNP
rs1359352871 2222 dbSNP
rs368088294 2222 dbSNP
rs1305829155 2236 dbSNP
rs960561409 2239 dbSNP
rs1289009990 2241 dbSNP
rs1455268171 2245 dbSNP
rs1357403274 2255 dbSNP
rs1175050079 2262 dbSNP
rs1212913981 2265 dbSNP
rs1191795709 2267 dbSNP
rs895139088 2268 dbSNP
rs1257064572 2272 dbSNP
rs949535491 2280 dbSNP
rs1255965755 2282 dbSNP
rs768504072 2288 dbSNP
rs1046899061 2292 dbSNP
rs991056815 2295 dbSNP
rs1264541155 2297 dbSNP
rs750144706 2300 dbSNP
rs182055474 2301 dbSNP
rs979142205 2308 dbSNP
rs755595467 2325 dbSNP
rs386820546 2336 dbSNP
rs115957677 2337 dbSNP
rs1011205923 2338 dbSNP
rs186641478 2339 dbSNP
rs115429978 2340 dbSNP
rs1168360623 2340 dbSNP
rs1465286886 2344 dbSNP
rs935578043 2347 dbSNP
rs1040682673 2348 dbSNP
rs561911314 2354 dbSNP
rs1373904263 2358 dbSNP
rs1195380376 2364 dbSNP
rs923515574 2366 dbSNP
rs779952534 2369 dbSNP
rs932192983 2371 dbSNP
rs765911129 2377 dbSNP
rs1051018791 2380 dbSNP
rs1378085785 2391 dbSNP
rs1465372575 2397 dbSNP
rs887880368 2407 dbSNP
rs1228907319 2414 dbSNP
rs529320387 2422 dbSNP
rs1362217482 2426 dbSNP
rs1311840666 2431 dbSNP
rs1030482065 2432 dbSNP
rs1329019571 2440 dbSNP
rs1400905950 2449 dbSNP
rs753373806 2450 dbSNP
rs550624228 2455 dbSNP
rs1397432841 2463 dbSNP
rs117308604 2470 dbSNP
rs897794589 2472 dbSNP
rs532923500 2484 dbSNP
rs1002819216 2489 dbSNP
rs1367961124 2491 dbSNP
rs1359999071 2492 dbSNP
rs1034937855 2494 dbSNP
rs577387952 2496 dbSNP
rs942293136 2500 dbSNP
rs1178367036 2501 dbSNP
rs1438772761 2508 dbSNP
rs1012096036 2526 dbSNP
rs747829269 2546 dbSNP
rs1197190170 2547 dbSNP
rs967829350 2548 dbSNP
rs916608269 2554 dbSNP
rs11552176 2562 dbSNP
rs1246139316 2563 dbSNP
rs1361465337 2566 dbSNP
rs949398413 2567 dbSNP
rs1312060984 2568 dbSNP
rs1336131664 2574 dbSNP
rs1330721666 2576 dbSNP
rs1385295054 2580 dbSNP
rs1390351364 2614 dbSNP
rs1303801524 2619 dbSNP
rs769089672 2620 dbSNP
rs979559894 2626 dbSNP
rs1378951401 2628 dbSNP
rs566379902 2637 dbSNP
rs1158587942 2639 dbSNP
rs894455695 2639 dbSNP
rs1365911882 2645 dbSNP
rs1354847483 2647 dbSNP
rs147524215 2648 dbSNP
rs1490703986 2648 dbSNP
rs1491023586 2648 dbSNP
rs565634830 2648 dbSNP
rs796302623 2648 dbSNP
rs879222924 2648 dbSNP
rs902570609 2648 dbSNP
rs1230840496 2649 dbSNP
rs934513063 2651 dbSNP
rs1052851907 2652 dbSNP
rs892966056 2653 dbSNP
rs1011490039 2654 dbSNP
rs1317810409 2664 dbSNP
rs1012850210 2665 dbSNP
rs1261969342 2666 dbSNP
rs1484620563 2667 dbSNP
rs1430803615 2670 dbSNP
rs1192372325 2671 dbSNP
rs1267980574 2673 dbSNP
rs1432591509 2675 dbSNP
rs1171673462 2678 dbSNP
rs1428108377 2682 dbSNP
rs1199717070 2691 dbSNP
rs533826248 2697 dbSNP
rs1260388330 2702 dbSNP
rs1191910355 2705 dbSNP
rs1447479704 2714 dbSNP
rs1420046805 2717 dbSNP
rs900194110 2718 dbSNP
rs549294664 2720 dbSNP
rs923677614 2731 dbSNP
rs1225580625 2733 dbSNP
rs1338796857 2734 dbSNP
rs956399928 2735 dbSNP
rs975728849 2741 dbSNP
rs1332798328 2744 dbSNP
rs567117769 2752 dbSNP
rs747935858 2756 dbSNP
rs1030101242 2758 dbSNP
rs1407292262 2759 dbSNP
rs1179104361 2764 dbSNP
rs923545095 2765 dbSNP
rs1366988512 2773 dbSNP
rs1439413857 2780 dbSNP
rs1312068212 2782 dbSNP
rs35624140 2783 dbSNP
rs373405868 2783 dbSNP
rs1185333836 2784 dbSNP
rs1460870110 2788 dbSNP
rs1243518565 2793 dbSNP
rs1205387738 2795 dbSNP
rs1316265136 2796 dbSNP
rs1272602964 2797 dbSNP
rs1222 2800 dbSNP
rs1341580862 2804 dbSNP
rs1050633634 2805 dbSNP
rs1282874217 2805 dbSNP
rs559344697 2811 dbSNP
rs1016480214 2813 dbSNP
rs140395169 2836 dbSNP
rs963520297 2836 dbSNP
rs577820898 2840 dbSNP
rs1314697182 2845 dbSNP
rs907031388 2854 dbSNP
rs1265575011 2855 dbSNP
rs1169321116 2856 dbSNP
rs1409970688 2858 dbSNP
rs386820547 2860 dbSNP
rs538777880 2861 dbSNP
rs558380392 2862 dbSNP
rs573411931 2863 dbSNP
rs909332474 2878 dbSNP
rs540551835 2882 dbSNP
rs781250922 2889 dbSNP
rs1185162813 2892 dbSNP
rs942132844 2893 dbSNP
rs1456294174 2894 dbSNP
rs746133358 2894 dbSNP
rs1232459874 2898 dbSNP
rs1205496718 2904 dbSNP
rs1287784504 2905 dbSNP
rs1439833839 2905 dbSNP
rs1245388409 2922 dbSNP
rs1360745992 2925 dbSNP
rs1317798037 2926 dbSNP
rs991098978 2927 dbSNP
rs1191707532 2928 dbSNP
rs916803040 2930 dbSNP
rs949429115 2936 dbSNP
rs1239896300 2937 dbSNP
rs770172921 2939 dbSNP
rs897910274 2940 dbSNP
rs1177719689 2948 dbSNP
rs1366061998 2952 dbSNP
rs1002850537 2953 dbSNP
rs1057033187 2954 dbSNP
rs896422304 2955 dbSNP
rs1177617975 2957 dbSNP
rs924055869 2961 dbSNP
rs562417825 2963 dbSNP
rs1406071018 2966 dbSNP
rs775667327 2967 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 150275.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucAGUUAUGGAACacu 5'
                  |: || |||||   
Target 5' ---uuuucUUCAU-CCUUG--- 3'
 		1 - 15
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucAGUUAUGGAACACu 5'
                  |: || ||||||| 
Target 5' ---uuuucUUCAU-CCUUGUGg 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000249064.4 | 3UTR | UUUUCUUCAUCCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000249064.4 | 3UTR | UUUUCUUCAUCCUUGUGGUGCUUAUUCAUCUGAGCCGUCUCCACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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