miRTarBase - #MIRT480886


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pre-miRNA Information
pre-miRNA hsa-mir-4529   
Genomic Coordinates chr18: 55479221 - 55479298
Description Homo sapiens miR-4529 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4529-5p
Sequence 6| AGGCCAUCAGCAGUCCAAUGAA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325288049 1 dbSNP
rs1233088462 15 dbSNP
rs1324866273 19 dbSNP
Putative Targets

Gene Information
Gene Symbol BCL9L   
Synonyms BCL9-2, DLNB11
Description B-cell CLL/lymphoma 9 like
Transcript NM_182557   
Expression
Putative miRNA Targets on BCL9L
3'UTR of BCL9L
(miRNA target sites are highlighted)		 
>BCL9L|NM_182557|3'UTR
   1 AAGTCGCTGCCAGGGCTGGAGCCGGGGCAATGTTGCAAATACGATAACCTTAACAAAGTTCTTCCCCTCAATGTTGGGAT
  81 GGCCTGGGTCGCGGGGTGGGGTGGAGGGGGTGGGAGGGGGCTTGTGTAGGGAGTGGCATTTGTGGAAACCAGATGTGCTG
 161 GCAGCTTAGGGGGAAGTGGCAGTGTGGGGTGGGGGATTTTGCATTGGGGTTGGTTCCATTTCGGCCACCAGGACTGCCCC
 241 TCCCCCACTCCTCCCAATTCCTATGGAGCCTCTCTATTTTACCTCTTTCCGTGCATCCCTGCACCCGCCACACCCCCTTC
 321 AGCTATGCTTTTGGAGTCCTGGATGGGAATCTGGGGGGAGAGAGGAAGGACAGGTCAGGTCTCCCCCAGCCCCTTCTGCT
 401 CCTGTCTCCTCGTGTCCGCATTGCTGGAGCTCCACCTCCCTCTTGGTTTCTCCGCACCCGCCCATTTTCCTTCTGTCTTT
 481 ACCTGCTTCGTATCCTTTCCCTGCTGATGTGGCTGACCCCTCTCCCACCCCTCCCTGCAGGCGGCTGGCCAGGTGGGCAG
 561 GTGCCAGCCGGAGCTGTAAATAGAGCGCTGCGCTTTTGTGCTGGTTTGTGCGTGTGCTGTATTTCTGTGTTTTGATAGAA
 641 GTCACACAAAAAAAAAAGGATAAAAGAAACCCTTCCCCCCTTCTTCAAGTTATTGCTCCCTCCATTCCCCTGGACCCAGG
 721 GACATGCAGCCCTACATGGCCACCCACTGTTTGCAGTGTCTCTGGGTCCCTAAGGGATACCATTCCTGTCTCGTCCCCAA
 801 ATGGTAAGATGACGTAAATGACCCACTCCTAAACTGAGGTCAGACCACCTAGGCTTCCACCTGGTGAGCCCTAGCAGGGC
 881 TGAGACCCCCAGGGCGGCAGCCTGTCTGCTGCTGAGTGATTCAGGGAGAACATGTGTGCACGTGCATGTGTGTTTGCCCA
 961 CACCGGTGACACGGGGCCCTGGCTTTCCACTTTGGATGCCCGGGCATCCGCTGCTGCTACATCTTAGCCAGAACTTGAAG
1041 TCTTTTGTCCCAGTTTGGGATGAAGGAAAGGAGGAAGAGGCGGTGGCTGTGTGGCCCCCTTGAGTGGAGCCATGGAAGGG
1121 GTGGCATGGTGCCACTGGGGCCTGTGGCTGTAGTAGCCCTGGGCCAGGTAACCTCCAGGGCCCTGACTTTTCCAGAGGCT
1201 GCTGCCACCTACTTCTTATCAAAGAAGGGGGAGAACAGTTCATCTGAGTCAGTGCACCTCCCCTCCAGTCTCCACTCCCT
1281 GAGGATGGAATCGGGGAAACAGCATCCTGCCGCCTCCTCTCTGCCTGCCCACTCACCGGCAAGGTTGTCCCTCTGCCCAG
1361 GGCTCAGGGCCATGTACCAGATCTGTCTGTGCCCACCCAGGCACAGCCACTGCCTCCCCCTTGGCTCCCTGCTCCTACCC
1441 AGGAGAGCTCCCTATCCGCCTTTGGTCAGAGCTGAAGCCATATACGACTGGGTGTTTGTCCCCCTACTTTGGCCCCAGGA
1521 GTAAAAAAACTTCTCCTTTTCTCACTTCCTTTCCTGCCTCGGGAGGTGGCAGGGCAGTTCCCTGGCTGAGGCCTTTTGCG
1601 CCCCACCTCCAGGACCAAGGGCCATTCTAGACAGGGTGTCTTCTACCAGGACCCGTCCCTAGCCTTCCTGGCCTGGAGGG
1681 CCTGGTCTTGCACTGGCAGCTGTAATACAAAGGGAACTCGCCCCACTTCTCCCAGCCTGGTGCTGTCCTCTCGGCCCACC
1761 ATCGGCCAGGTCCAGCGCTTCCTCTGGGGCTGACAACAGGCCCCTGACTCACCCCGGTCACCTCCCAGGGTCCATGGCCA
1841 GGGCCTCTGTGTTTGGGGGGCCACTTGCCCTTCATCCTGCCAGGCGCTTTGCCCGCCCTGCCTCAGCCTGGGCCCTGTGC
1921 CCTTGAGCCCTCCACCCCTGGCCCAAGACCCCCCCAAACTGTCTGACTCTGTGTTTCCTGCCCTGAGGAGAGAGGGGTCA
2001 GATTGCAGCGGGCCGAGTGCCCTCTCCGTCCCCTCTCCTCCCACCCACGCCACAGGCCAGCCTACTCTTCCCTCCATCCA
2081 TGGCCACACCCCCAGCCATTTTGTACCATTATATAAATATATATATAAATATAAATATATAAATACAATATGTGAAGACA
2161 TCTTCTTGGTTTTTATTTTGAAACAATTTTTAGGCTTGTTCCGGGGGTCTCTGTGCTGCCTGTACTGTATTGACCTGTTT
2241 TATAGGTGCCTTTTTATTAAAAAGAAAATTCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaguaaccUGACGA--CUACCGGa 5'
                  | ||:|  ||||||| 
Target 5' ttcccctcAATGTTGGGATGGCCt 3'
 62 - 85 148.00 -15.40
2 
miRNA  3' aaguAACCUGACGA-CUACCgga 5'
              ||||| | || |||||   
Target 5' gcttTTGGAGTCCTGGATGGgaa 3'
 327 - 349 126.00 -12.22
3 
miRNA  3' aaguaACCUGACGACUACCGGa 5'
               ||| |||  || |||| 
Target 5' cttccTGGCCTG--GAGGGCCt 3'
 1664 - 1683 125.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28510750 15 COSMIC
COSN16131500 61 COSMIC
COSN30109649 61 COSMIC
COSN8939415 92 COSMIC
COSN25833190 115 COSMIC
COSN28636791 303 COSMIC
COSN20077454 307 COSMIC
COSM159355 634 COSMIC
COSN20108835 647 COSMIC
COSN26648179 647 COSMIC
COSN15665360 648 COSMIC
COSN19729859 657 COSMIC
COSN32074073 682 COSMIC
COSN5297594 733 COSMIC
COSN31486629 814 COSMIC
COSN31486844 866 COSMIC
COSN31555195 945 COSMIC
COSN31514372 1082 COSMIC
COSN31528059 1205 COSMIC
COSN31549257 1215 COSMIC
COSN14616629 1244 COSMIC
COSN31533632 1256 COSMIC
COSN26669735 1260 COSMIC
COSN30174340 1321 COSMIC
COSN24303778 1343 COSMIC
COSN26636299 1439 COSMIC
COSN30539941 1459 COSMIC
COSN19656302 1493 COSMIC
COSN6406233 1561 COSMIC
COSN31588224 1673 COSMIC
COSN31480875 1752 COSMIC
COSN31481044 1763 COSMIC
COSN28162881 1841 COSMIC
COSN27163869 2041 COSMIC
COSN24967937 2123 COSMIC
COSN30175925 2211 COSMIC
rs75438046 1560 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1218942725 1 dbSNP
rs997714797 2 dbSNP
rs1179506255 4 dbSNP
rs768821935 5 dbSNP
rs375604809 6 dbSNP
rs1323294082 7 dbSNP
rs1162811177 9 dbSNP
rs1313093714 15 dbSNP
rs772154290 18 dbSNP
rs372126201 23 dbSNP
rs201919848 24 dbSNP
rs780354151 27 dbSNP
rs778304522 30 dbSNP
rs755786683 35 dbSNP
rs752401030 39 dbSNP
rs767075694 41 dbSNP
rs1230934988 42 dbSNP
rs12417867 42 dbSNP
rs751094289 43 dbSNP
rs1416024529 48 dbSNP
rs1213678802 67 dbSNP
rs557075070 68 dbSNP
rs1057185817 69 dbSNP
rs1436463075 71 dbSNP
rs1433810216 79 dbSNP
rs1373402918 80 dbSNP
rs538775772 82 dbSNP
rs1178138887 83 dbSNP
rs1415031244 84 dbSNP
rs1418870455 85 dbSNP
rs1184899976 86 dbSNP
rs1253186287 88 dbSNP
rs1478862830 90 dbSNP
rs571213576 91 dbSNP
rs11217081 92 dbSNP
rs1187514781 93 dbSNP
rs1417583271 93 dbSNP
rs1484856733 97 dbSNP
rs1239647259 99 dbSNP
rs1211421519 102 dbSNP
rs1307473001 105 dbSNP
rs1169627734 106 dbSNP
rs927832475 106 dbSNP
rs1314623176 109 dbSNP
rs976141031 111 dbSNP
rs1429368526 112 dbSNP
rs1268071289 113 dbSNP
rs762443735 114 dbSNP
rs965779943 115 dbSNP
rs1319411221 116 dbSNP
rs1347599176 116 dbSNP
rs945298235 120 dbSNP
rs1260186905 126 dbSNP
rs907303549 133 dbSNP
rs1443103772 136 dbSNP
rs1192496014 138 dbSNP
rs1240590230 153 dbSNP
rs1476474554 157 dbSNP
rs914876386 158 dbSNP
rs1394313347 169 dbSNP
rs534616193 170 dbSNP
rs1432598724 171 dbSNP
rs1175476121 175 dbSNP
rs375038248 177 dbSNP
rs1402766042 185 dbSNP
rs1278365252 193 dbSNP
rs1046202565 204 dbSNP
rs949227733 209 dbSNP
rs1435441731 210 dbSNP
rs1302205662 221 dbSNP
rs913695572 222 dbSNP
rs1232496529 223 dbSNP
rs1052215940 232 dbSNP
rs953776043 234 dbSNP
rs1346255569 238 dbSNP
rs936624024 240 dbSNP
rs1282327558 245 dbSNP
rs976527160 246 dbSNP
rs1252566616 252 dbSNP
rs965518892 255 dbSNP
rs1195204296 258 dbSNP
rs1378142956 260 dbSNP
rs1469625879 271 dbSNP
rs1156734163 274 dbSNP
rs1386566402 275 dbSNP
rs1168264824 276 dbSNP
rs567012485 276 dbSNP
rs1019967806 281 dbSNP
rs1015789178 283 dbSNP
rs1324834485 286 dbSNP
rs1467198383 290 dbSNP
rs1004440948 291 dbSNP
rs879134529 296 dbSNP
rs548485992 302 dbSNP
rs879207442 303 dbSNP
rs888705002 304 dbSNP
rs953140870 306 dbSNP
rs923060040 307 dbSNP
rs1209386599 313 dbSNP
rs1013333010 316 dbSNP
rs1474381339 317 dbSNP
rs1215786974 335 dbSNP
rs530204618 340 dbSNP
rs569136691 341 dbSNP
rs1436998401 351 dbSNP
rs746765186 352 dbSNP
rs1015141389 353 dbSNP
rs1006379820 354 dbSNP
rs952296673 355 dbSNP
rs76952529 358 dbSNP
rs1391140912 359 dbSNP
rs1327463328 376 dbSNP
rs180857346 381 dbSNP
rs565277336 383 dbSNP
rs1201085114 387 dbSNP
rs1256934063 390 dbSNP
rs1247324216 391 dbSNP
rs1001555680 393 dbSNP
rs1196104764 398 dbSNP
rs1429267398 400 dbSNP
rs755772734 401 dbSNP
rs540213324 402 dbSNP
rs1045815603 406 dbSNP
rs1273700055 408 dbSNP
rs1212888524 409 dbSNP
rs766322113 411 dbSNP
rs1279769647 412 dbSNP
rs891871871 413 dbSNP
rs1218787288 414 dbSNP
rs1187129358 415 dbSNP
rs1325361724 417 dbSNP
rs1052250719 418 dbSNP
rs965138189 420 dbSNP
rs1381055790 424 dbSNP
rs1370412606 429 dbSNP
rs1327140975 430 dbSNP
rs1166450994 433 dbSNP
rs1461304954 435 dbSNP
rs1392736103 438 dbSNP
rs936491527 453 dbSNP
rs1015736915 454 dbSNP
rs1462639860 454 dbSNP
rs925244454 459 dbSNP
rs1191165607 460 dbSNP
rs1434955070 464 dbSNP
rs1050742883 469 dbSNP
rs1192925008 475 dbSNP
rs1466972414 481 dbSNP
rs1259685292 483 dbSNP
rs1196040047 484 dbSNP
rs115131000 486 dbSNP
rs1224972152 487 dbSNP
rs765436253 489 dbSNP
rs762011943 490 dbSNP
rs760831278 495 dbSNP
rs561140310 499 dbSNP
rs1440730973 504 dbSNP
rs1260618665 505 dbSNP
rs1369264012 506 dbSNP
rs1333734565 518 dbSNP
rs907606542 520 dbSNP
rs1194864689 524 dbSNP
rs745929963 529 dbSNP
rs1166354612 531 dbSNP
rs542974283 532 dbSNP
rs1392475228 534 dbSNP
rs575498151 537 dbSNP
rs1467705430 538 dbSNP
rs774342902 539 dbSNP
rs1172950278 541 dbSNP
rs771419655 542 dbSNP
rs984974050 543 dbSNP
rs1182308515 553 dbSNP
rs1035665162 556 dbSNP
rs1248053529 566 dbSNP
rs557536380 569 dbSNP
rs1485717561 570 dbSNP
rs202069440 573 dbSNP
rs1234237750 574 dbSNP
rs1034615246 580 dbSNP
rs1346297472 585 dbSNP
rs1281755009 586 dbSNP
rs980720262 587 dbSNP
rs1411447840 590 dbSNP
rs1335538817 591 dbSNP
rs764095250 592 dbSNP
rs778214935 596 dbSNP
rs1210257487 600 dbSNP
rs756558835 604 dbSNP
rs1248220951 609 dbSNP
rs557234579 611 dbSNP
rs1432910126 612 dbSNP
rs1382151005 614 dbSNP
rs192428261 616 dbSNP
rs775601825 619 dbSNP
rs891906448 621 dbSNP
rs780984171 625 dbSNP
rs1054092993 626 dbSNP
rs1189209992 627 dbSNP
rs1033035732 636 dbSNP
rs577620512 637 dbSNP
rs1485768978 641 dbSNP
rs1256237664 642 dbSNP
rs1208162530 643 dbSNP
rs1488974898 645 dbSNP
rs754622536 646 dbSNP
rs201537577 647 dbSNP
rs373105851 648 dbSNP
rs76879408 648 dbSNP
rs201338453 649 dbSNP
rs745451082 649 dbSNP
rs1350424476 651 dbSNP
rs765842715 656 dbSNP
rs1369451256 658 dbSNP
rs1439901920 658 dbSNP
rs35636302 658 dbSNP
rs398115882 658 dbSNP
rs529976724 658 dbSNP
rs748662391 658 dbSNP
rs1235403683 660 dbSNP
rs1356381449 664 dbSNP
rs1292881674 670 dbSNP
rs1040741970 678 dbSNP
rs1000670131 679 dbSNP
rs758291010 680 dbSNP
rs1292086418 681 dbSNP
rs1399984244 681 dbSNP
rs1211429196 683 dbSNP
rs694769 694 dbSNP
rs1316112867 695 dbSNP
rs534286941 707 dbSNP
rs1192327047 709 dbSNP
rs1407843382 716 dbSNP
rs772184325 718 dbSNP
rs1471664335 723 dbSNP
rs759390793 724 dbSNP
rs903653143 725 dbSNP
rs1161377693 729 dbSNP
rs1412789147 730 dbSNP
rs1461173842 732 dbSNP
rs1324106766 733 dbSNP
rs1351443055 736 dbSNP
rs1436878846 742 dbSNP
rs943730461 747 dbSNP
rs908290346 752 dbSNP
rs1229706081 756 dbSNP
rs1242199416 760 dbSNP
rs774354710 762 dbSNP
rs148838473 769 dbSNP
rs34674464 771 dbSNP
rs1291541977 772 dbSNP
rs1302616891 775 dbSNP
rs770550519 780 dbSNP
rs952980795 785 dbSNP
rs1232813584 786 dbSNP
rs1050368308 792 dbSNP
rs145472817 793 dbSNP
rs958953608 800 dbSNP
rs901752506 801 dbSNP
rs1416162896 802 dbSNP
rs187098041 812 dbSNP
rs569097870 813 dbSNP
rs182056915 814 dbSNP
rs1359001827 822 dbSNP
rs1160869278 836 dbSNP
rs1420731429 837 dbSNP
rs967385137 847 dbSNP
rs1379372648 851 dbSNP
rs984505216 853 dbSNP
rs930828674 859 dbSNP
rs927491225 861 dbSNP
rs1020773330 862 dbSNP
rs1011685212 868 dbSNP
rs532742279 871 dbSNP
rs571607356 875 dbSNP
rs1053640101 887 dbSNP
rs972084506 893 dbSNP
rs1024495264 895 dbSNP
rs1185434277 896 dbSNP
rs1239441025 899 dbSNP
rs988792682 902 dbSNP
rs899753927 904 dbSNP
rs1388146684 909 dbSNP
rs1431370864 926 dbSNP
rs1041023762 932 dbSNP
rs572994779 934 dbSNP
rs1412273752 940 dbSNP
rs777286144 941 dbSNP
rs189845413 942 dbSNP
rs1000198472 946 dbSNP
rs769215527 950 dbSNP
rs1268011538 952 dbSNP
rs1218467828 954 dbSNP
rs1363501185 955 dbSNP
rs1231004831 959 dbSNP
rs528455360 963 dbSNP
rs1047236002 964 dbSNP
rs1029277859 965 dbSNP
rs1280901883 970 dbSNP
rs747699770 972 dbSNP
rs561303363 973 dbSNP
rs1246384126 975 dbSNP
rs901774398 978 dbSNP
rs1230978418 986 dbSNP
rs991673001 999 dbSNP
rs1040285035 1001 dbSNP
rs940345796 1002 dbSNP
rs1402345246 1003 dbSNP
rs1399571911 1004 dbSNP
rs981686923 1005 dbSNP
rs967332766 1006 dbSNP
rs542937261 1009 dbSNP
rs530875574 1010 dbSNP
rs1231771112 1014 dbSNP
rs185500774 1024 dbSNP
rs544836957 1028 dbSNP
rs577783324 1035 dbSNP
rs746458735 1038 dbSNP
rs559155341 1043 dbSNP
rs780519611 1046 dbSNP
rs758965475 1056 dbSNP
rs1449621927 1060 dbSNP
rs1378837665 1071 dbSNP
rs1200948744 1076 dbSNP
rs1044979667 1082 dbSNP
rs147283386 1095 dbSNP
rs750786126 1095 dbSNP
rs950223403 1096 dbSNP
rs996681105 1098 dbSNP
rs1156229415 1107 dbSNP
rs1413521191 1112 dbSNP
rs1477227443 1115 dbSNP
rs541148109 1123 dbSNP
rs1457501244 1124 dbSNP
rs1324782071 1129 dbSNP
rs560669838 1134 dbSNP
rs1390519089 1145 dbSNP
rs1333654651 1150 dbSNP
rs573284920 1153 dbSNP
rs1326138404 1155 dbSNP
rs899703041 1165 dbSNP
rs554982192 1180 dbSNP
rs1260524370 1186 dbSNP
rs78348329 1199 dbSNP
rs988990330 1216 dbSNP
rs779150450 1220 dbSNP
rs1354019745 1221 dbSNP
rs371621767 1224 dbSNP
rs757443868 1226 dbSNP
rs1437231094 1228 dbSNP
rs1256553212 1230 dbSNP
rs1179904330 1236 dbSNP
rs931025451 1238 dbSNP
rs954300112 1241 dbSNP
rs1028390851 1243 dbSNP
rs996423891 1246 dbSNP
rs1366302691 1249 dbSNP
rs754031623 1251 dbSNP
rs1316160332 1255 dbSNP
rs1165297410 1266 dbSNP
rs1391900260 1269 dbSNP
rs1055509366 1271 dbSNP
rs1280264256 1272 dbSNP
rs1400913690 1275 dbSNP
rs937493728 1283 dbSNP
rs73575411 1292 dbSNP
rs1312292921 1293 dbSNP
rs981630800 1298 dbSNP
rs1247250112 1299 dbSNP
rs1341172390 1311 dbSNP
rs946319843 1312 dbSNP
rs115926645 1313 dbSNP
rs886346420 1316 dbSNP
rs1048785828 1319 dbSNP
rs990174261 1323 dbSNP
rs957633908 1324 dbSNP
rs1369447280 1327 dbSNP
rs1403486543 1329 dbSNP
rs1167286460 1330 dbSNP
rs571841469 1337 dbSNP
rs1464593904 1338 dbSNP
rs1302399959 1346 dbSNP
rs974846585 1347 dbSNP
rs519925 1355 dbSNP
rs1398053472 1374 dbSNP
rs1313674399 1380 dbSNP
rs963857279 1381 dbSNP
rs905628874 1383 dbSNP
rs1225842887 1398 dbSNP
rs1044125012 1399 dbSNP
rs1342705592 1410 dbSNP
rs1209331471 1415 dbSNP
rs1253800400 1418 dbSNP
rs1008122141 1419 dbSNP
rs1246976120 1424 dbSNP
rs1449255451 1425 dbSNP
rs1186989710 1427 dbSNP
rs1225017001 1432 dbSNP
rs1392408590 1439 dbSNP
rs950274617 1447 dbSNP
rs1450697533 1452 dbSNP
rs546765409 1457 dbSNP
rs116454680 1458 dbSNP
rs1467616784 1464 dbSNP
rs1303669875 1478 dbSNP
rs764195369 1485 dbSNP
rs1443954955 1486 dbSNP
rs1256702764 1492 dbSNP
rs1195161843 1498 dbSNP
rs898181030 1503 dbSNP
rs1218627529 1506 dbSNP
rs1299053963 1514 dbSNP
rs1456498541 1518 dbSNP
rs181036545 1519 dbSNP
rs1233265315 1526 dbSNP
rs1267106169 1533 dbSNP
rs557288355 1535 dbSNP
rs779420891 1535 dbSNP
rs907358279 1538 dbSNP
rs1250342163 1545 dbSNP
rs954040892 1554 dbSNP
rs549352362 1555 dbSNP
rs1247377110 1556 dbSNP
rs75438046 1560 dbSNP
rs1306826856 1562 dbSNP
rs1411325658 1573 dbSNP
rs1455898539 1576 dbSNP
rs1389146544 1581 dbSNP
rs913475548 1581 dbSNP
rs1435429953 1583 dbSNP
rs1291728857 1599 dbSNP
rs1297609480 1600 dbSNP
rs1387270535 1601 dbSNP
rs1287224189 1603 dbSNP
rs1397480258 1607 dbSNP
rs1332842628 1627 dbSNP
rs35410777 1631 dbSNP
rs990845847 1633 dbSNP
rs764788658 1634 dbSNP
rs935997280 1639 dbSNP
rs1317923215 1650 dbSNP
rs1465721133 1654 dbSNP
rs1389510400 1655 dbSNP
rs1161113937 1656 dbSNP
rs1473618554 1667 dbSNP
rs1368906194 1669 dbSNP
rs965450364 1670 dbSNP
rs1200765172 1671 dbSNP
rs1018821251 1675 dbSNP
rs1471634106 1678 dbSNP
rs1184639586 1680 dbSNP
rs188530930 1685 dbSNP
rs1019427273 1695 dbSNP
rs879776996 1700 dbSNP
rs950634651 1707 dbSNP
rs1307302182 1719 dbSNP
rs1348117138 1720 dbSNP
rs1199304151 1721 dbSNP
rs551674149 1722 dbSNP
rs1451130849 1731 dbSNP
rs1287920079 1733 dbSNP
rs1027547667 1748 dbSNP
rs951331627 1752 dbSNP
rs1211860843 1753 dbSNP
rs994925698 1755 dbSNP
rs905495523 1757 dbSNP
rs1044542759 1758 dbSNP
rs1279396701 1760 dbSNP
rs1207300731 1763 dbSNP
rs1014047149 1764 dbSNP
rs1379711851 1765 dbSNP
rs1310662310 1766 dbSNP
rs1472623469 1767 dbSNP
rs545684155 1768 dbSNP
rs532960564 1772 dbSNP
rs1415742171 1774 dbSNP
rs752881171 1776 dbSNP
rs1167911532 1781 dbSNP
rs3209229 1783 dbSNP
rs962378892 1785 dbSNP
rs1431113506 1787 dbSNP
rs767558219 1789 dbSNP
rs3209230 1790 dbSNP
rs1406795954 1795 dbSNP
rs141944776 1803 dbSNP
rs904803662 1815 dbSNP
rs1285561074 1816 dbSNP
rs1157868100 1817 dbSNP
rs1247098516 1818 dbSNP
rs1297512893 1831 dbSNP
rs1340748047 1839 dbSNP
rs906969132 1847 dbSNP
rs147752607 1854 dbSNP
rs1208318911 1858 dbSNP
rs1382043399 1861 dbSNP
rs1461616135 1866 dbSNP
rs114219531 1878 dbSNP
rs891981953 1880 dbSNP
rs1054699357 1881 dbSNP
rs1168404862 1882 dbSNP
rs561448373 1884 dbSNP
rs555948454 1885 dbSNP
rs977146970 1886 dbSNP
rs921902817 1893 dbSNP
rs944131045 1894 dbSNP
rs1406266691 1895 dbSNP
rs1433897912 1898 dbSNP
rs1320371454 1899 dbSNP
rs908607840 1902 dbSNP
rs1363437837 1907 dbSNP
rs1231303093 1908 dbSNP
rs944726473 1913 dbSNP
rs1344423140 1918 dbSNP
rs1452456152 1920 dbSNP
rs1217492587 1923 dbSNP
rs983300634 1924 dbSNP
rs542970845 1927 dbSNP
rs1285619065 1930 dbSNP
rs1208335867 1947 dbSNP
rs1214845468 1948 dbSNP
rs983966718 1950 dbSNP
rs766106371 1952 dbSNP
rs951234666 1954 dbSNP
rs1219228197 1955 dbSNP
rs1476757707 1956 dbSNP
rs554540102 1956 dbSNP
rs1429364683 1957 dbSNP
rs1156460904 1959 dbSNP
rs1456423062 1959 dbSNP
rs762624114 1965 dbSNP
rs1343659711 1966 dbSNP
rs1272622348 1967 dbSNP
rs1386942463 1968 dbSNP
rs575646091 1969 dbSNP
rs1384225505 1971 dbSNP
rs973994646 1975 dbSNP
rs1027995218 1985 dbSNP
rs962950567 1989 dbSNP
rs1434942934 1990 dbSNP
rs973307579 1995 dbSNP
rs557350357 2003 dbSNP
rs539355358 2009 dbSNP
rs578105206 2010 dbSNP
rs553580654 2011 dbSNP
rs971076813 2014 dbSNP
rs772705742 2015 dbSNP
rs1297222906 2025 dbSNP
rs1162924088 2028 dbSNP
rs1397844665 2031 dbSNP
rs1200885620 2038 dbSNP
rs71482158 2040 dbSNP
rs1269020722 2044 dbSNP
rs535234229 2046 dbSNP
rs581063 2047 dbSNP
rs183762696 2048 dbSNP
rs904649911 2049 dbSNP
rs1043613835 2056 dbSNP
rs1390454384 2057 dbSNP
rs1404151872 2076 dbSNP
rs1305458318 2078 dbSNP
rs1346267454 2082 dbSNP
rs3782048 2087 dbSNP
rs900749861 2089 dbSNP
rs900068283 2092 dbSNP
rs1191788256 2098 dbSNP
rs1041072773 2103 dbSNP
rs1283430800 2106 dbSNP
rs1353952858 2108 dbSNP
rs1264421424 2111 dbSNP
rs559739639 2121 dbSNP
rs911925821 2123 dbSNP
rs551370085 2125 dbSNP
rs908639077 2126 dbSNP
rs982831692 2127 dbSNP
rs1047779575 2128 dbSNP
rs1202316370 2128 dbSNP
rs929128944 2128 dbSNP
rs918388217 2131 dbSNP
rs1368298663 2132 dbSNP
rs974320817 2134 dbSNP
rs558537383 2137 dbSNP
rs1323640430 2140 dbSNP
rs1366673652 2140 dbSNP
rs1306320450 2144 dbSNP
rs35022133 2145 dbSNP
rs1277105487 2148 dbSNP
rs927209691 2152 dbSNP
rs1216480592 2161 dbSNP
rs1342123453 2162 dbSNP
rs980011057 2165 dbSNP
rs552272713 2168 dbSNP
rs1447157850 2183 dbSNP
rs1247821178 2187 dbSNP
rs1024403064 2193 dbSNP
rs1357311581 2194 dbSNP
rs1226070417 2196 dbSNP
rs1336110066 2201 dbSNP
rs973636826 2203 dbSNP
rs970030862 2207 dbSNP
rs1033144681 2224 dbSNP
rs1168778325 2232 dbSNP
rs1185743146 2232 dbSNP
rs55938970 2237 dbSNP
rs55820058 2238 dbSNP
rs1478953848 2250 dbSNP
rs1386233866 2254 dbSNP
rs14811 2264 dbSNP
rs1000771263 2272 dbSNP
rs1053877 2280 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000334801.3 | 3UTR | CCUACUCUUCCCUCCAUCCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
57 hsa-miR-4529-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT226211 TMEM64 transmembrane protein 64 2 2
MIRT241576 LAMC1 laminin subunit gamma 1 2 8
MIRT311423 LMNB1 lamin B1 2 2
MIRT458476 RMI1 RecQ mediated genome instability 1 2 10
MIRT476949 FAM83G family with sequence similarity 83 member G 2 2
MIRT480886 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT492825 NXN nucleoredoxin 2 4
MIRT495860 CLCN6 chloride voltage-gated channel 6 2 2
MIRT495919 FBXO41 F-box protein 41 2 2
MIRT497150 PRDM15 PR/SET domain 15 2 2
MIRT498695 LYRM2 LYR motif containing 2 2 4
MIRT499954 ABI2 abl interactor 2 2 2
MIRT501309 RPS21 ribosomal protein S21 2 2
MIRT505941 RAP2C RAP2C, member of RAS oncogene family 2 4
MIRT508422 SFTPB surfactant protein B 2 2
MIRT510705 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT513225 RYK receptor-like tyrosine kinase 2 2
MIRT513775 PER1 period circadian clock 1 2 6
MIRT514948 CD36 CD36 molecule 2 2
MIRT515902 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT516066 RAB42 RAB42, member RAS oncogene family 2 2
MIRT523010 IL6R interleukin 6 receptor 2 2
MIRT525065 FRK fyn related Src family tyrosine kinase 2 2
MIRT530304 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530445 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT532421 ITFG2 integrin alpha FG-GAP repeat containing 2 2 2
MIRT532626 PHF5A PHD finger protein 5A 2 2
MIRT535128 PLK2 polo like kinase 2 2 2
MIRT539608 SHISA9 shisa family member 9 2 2
MIRT539640 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540213 RAB32 RAB32, member RAS oncogene family 2 2
MIRT540333 OPHN1 oligophrenin 1 2 2
MIRT544350 EGLN1 egl-9 family hypoxia inducible factor 1 2 2
MIRT547521 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548546 DR1 down-regulator of transcription 1 2 2
MIRT554545 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 2
MIRT558545 CSNK1A1 casein kinase 1 alpha 1 2 2
MIRT558619 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 4
MIRT563009 U2AF2 U2 small nuclear RNA auxiliary factor 2 2 2
MIRT565148 TUBB2A tubulin beta 2A class IIa 2 2
MIRT567297 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT569071 CADM2 cell adhesion molecule 2 2 2
MIRT570338 VAV3 vav guanine nucleotide exchange factor 3 2 2
MIRT573548 RHOA ras homolog family member A 2 2
MIRT573955 FIGNL1 fidgetin like 1 2 2
MIRT608235 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT610627 SPTA1 spectrin alpha, erythrocytic 1 2 6
MIRT613784 RPS6 ribosomal protein S6 2 2
MIRT620437 CARNS1 carnosine synthase 1 2 2
MIRT629393 CLEC17A C-type lectin domain containing 17A 2 2
MIRT637409 NKX2-3 NK2 homeobox 3 2 2
MIRT659086 DENR density regulated re-initiation and release factor 2 2
MIRT687349 NUP98 nucleoporin 98 2 2
MIRT688532 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT701007 PCSK6 proprotein convertase subtilisin/kexin type 6 2 2
MIRT715878 ACIN1 apoptotic chromatin condensation inducer 1 2 2
MIRT723149 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4529 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4529-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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