miRTarBase - #MIRT481118


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pre-miRNA Information
pre-miRNA hsa-mir-4677   
Genomic Coordinates chr1: 243346176 - 243346255
Description Homo sapiens miR-4677 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4677-5p
Sequence 13| UUGUUCUUUGGUCUUUCAGCCA |34
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN10045564 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1050583047 19 dbSNP
rs1425855779 21 dbSNP
Putative Targets

Gene Information
Gene Symbol AZIN1   
Synonyms AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L
Description antizyme inhibitor 1
Transcript NM_015878   
Other Transcripts NM_148174   
Expression
Putative miRNA Targets on AZIN1
3'UTR of AZIN1
(miRNA target sites are highlighted)		 
>AZIN1|NM_015878|3'UTR
   1 ACAGGCATTAACGCTTCTTTAGATCTGAAGTTGCAGGTTAAGCTTGTCTGGTCAACATTCCAGTGTGGAAAAATAATTTA
  81 AACAATCTTATTCTCTTAATTCTTTTGGCAACAAAAACTATTAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCA
 161 TCTATAATTCATTGGGGATAATGGGAGATTTAGATAATGTATCCAGATTTAAACCTACCAGTTTGTCCTACCCCTTAAGC
 241 GTTTAAAATAAAATATGCAACAAAATGGATGACTTAGTGGAGATGGAAGCCCATTAATTGGGTTCCCCATTAAATCGTTT
 321 ACATACAAGAACACAGTTTTTATACTAAGGATTTGTGTTTAAAGTCTTGTAAAGTTCATGTCTTTCACCCAGATATATCA
 401 AATGTTAGAAGACCAGTGTGACTTCATTAGATAACGTTTAGTGTATTTAGAATGTGTAAATTTGTGCTTTGAACTGTAGT
 481 TTAATAAATGTAAAATTGCATCATAGTATTTGTTGACCTAATGTAACCCTTGTATGATTGCAATAAAATTTTGTGTAGAT
 561 TTTACTGTTTTTTCAGGCTAAAACTTTGGGAAAGGGGCTAGCTAGCAAAGGTAGTTTTGAAATAGATGTGTATATGGACT
 641 GTTTTGAAGGGTTTTTTTCTTTATAGCCCAGTTAAGTTTTGTTTGGCTCGGTGCATTTTTCATTTATTTAATTAGTAATT
 721 TAAGTAAAGTGTTTGGTAAATCATTGTGAAGTTCAGATTCATTATGGAGAGTTGATGTGCAGTAAGCATGATGTTTAACA
 801 ATTTTAACACCAAAAATGTTAATCCTGCATAAATCAACTGTAATAATAAATAGGTGTTTCTGTATAGATAGAATGCATAG
 881 AGTACCTTAGTAAATCTTTGAATCACAATCTTTTGGCTGAAATGGAAGATTCTGTTAAATACTTTGAATAAACTTGGGGG
 961 GAGGGAAATAAAATTGCAGAAAACTGCAGAGCACTAAAACTTAAAGAAGGGCTACATCTTTATCCAGAAACCTGTTGCTC
1041 TTTTGCACGGAATGTTTAAATTCAGAGTTGGGATGGGGGTTGGGGTGAAGCACACTTATTATCTTCAGTTGCAGTGATTT
1121 CAAATTTAGGATTTTTTGTTGTTGGTTTGAACTGTCCCCTTAGTTTCTTGTTATTTCCAATTTGTTCTGCTTAGTCATTA
1201 CTTTTAATTCTTTTCTTACTAAAATTTTATGGTGGTTGGGGGAAGGGAGTTAGCATCACTAACCTGACAGTTGTTGCCAG
1281 GAATTTGCTTTGTTTACTGCTAGTATATTAGAAATCCTAGATCTCAGAATCACAATAGTAATAAACAACAGGGGTCATTT
1361 TTTCCTAACTTACTCTGTGTTCAGGTGTGGAATTTCTGTCTCCCAAGAGGAAATGTGACTTCACTTTGGTGCCAATGGAC
1441 AGAAAATTCTACCTGTGCTACATAGGAGAAGTTTGGAATGCACTTAATAGCTGGTTTTTACACCTTGATTTCGAGGTGGA
1521 AAGAAATTGATCATGAATCTCTAATAAATTTAAATCTCTTAAACCAGTAGGTGCTTAATATTTTTTGATTTGATTAATGC
1601 CCATTTAAATCTCATGGGTTCTATTAAAAATATATATATATAGGGCCCCAATCCATTGCCATCAAATTGCCCTTGGACTT
1681 TTCCAAGGTATATTATGGGGTTTTATGCAAAATTCCAAGCTACCATGTAACTTTTTTTAACCATTTAACAAGGAGGGGGA
1761 ACTGTTTCCTACCTTCTTTACATGTTGTGCATTGTTGTGGTCCAGAAATGCCAAACCTTTTTAAAGATGGTGCAACTTTG
1841 AGTCCTTGGCTTGACTATACAGGCCTTGAACTTCATGGCATATCAACTTTGCCATATCTGCAGGAGAGCTGTTCTATAAG
1921 AAATAGCTCAGAGTTGCAAATATCACATGTGAATGATACGGTAACTTTTAAGAAATGTCTGTATTGTATTTGAAGACTGT
2001 TTGCCATAAATCTGAAATTTGAACCTATGTATTTCAATTTGGTATGCTAAAAAGTTCTGAATTAATGTAAAGTTTTTTGT
2081 TATAATATTGTAATCTCAGTTCAAAAGTTAACTGCAAATATAAAACCCAATGATTTCTATATAGTAAATTGAACTGTAAA
2161 GGTAACTTGTGTGTGATTCTGAATACATAGATAAATGTTTTTATTCCTCATGTTTTACTTTGGCTTCTATCTGAAATAGA
2241 GGTAAAATTTTACATATCAGCTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acCGACUUUCUGGUUUCUUGUu 5'
            |:| | | ||  ||||||| 
Target 5' tcGTTTACATAC--AAGAACAc 3'
 315 - 334 152.00 -5.80
2 
miRNA  3' acCGACUUUCUGGUUUCUUGUu 5'
            || |||| ||:: |||:|| 
Target 5' ttGCAGAAA-ACTGCAGAGCAc 3'
 974 - 994 123.00 -9.20
3 
miRNA  3' accgACUUUCUGGU-UUCUUGUu 5'
              | ||| :::| |||| || 
Target 5' tataTCAAATGTTAGAAGACCAg 3'
 394 - 416 122.00 -10.54
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30508383 13 COSMIC
COSN24302602 54 COSMIC
COSN30521329 85 COSMIC
COSN31548254 102 COSMIC
COSN30533363 171 COSMIC
COSN31513050 240 COSMIC
COSN31575881 559 COSMIC
COSN31575893 563 COSMIC
COSN31480823 701 COSMIC
COSN26481763 742 COSMIC
COSN31547513 846 COSMIC
COSN6902036 984 COSMIC
COSN24041895 1215 COSMIC
COSN22281665 1454 COSMIC
COSN31490889 1468 COSMIC
COSN31527919 1484 COSMIC
COSN22028505 1512 COSMIC
COSN31491041 1529 COSMIC
COSN31609769 1551 COSMIC
COSN28662085 1633 COSMIC
COSN31596212 1637 COSMIC
COSN31547885 1663 COSMIC
COSN31481177 1768 COSMIC
COSN30174177 1826 COSMIC
COSN31529521 2018 COSMIC
COSN16349167 2104 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763618651 4 dbSNP
rs375544784 12 dbSNP
rs200238843 13 dbSNP
rs1241429719 16 dbSNP
rs1200586035 20 dbSNP
rs981667901 25 dbSNP
rs759491354 27 dbSNP
rs769852042 33 dbSNP
rs774454737 37 dbSNP
rs771096872 39 dbSNP
rs1373139683 43 dbSNP
rs563805985 55 dbSNP
rs927104462 63 dbSNP
rs1165686031 83 dbSNP
rs1366361860 84 dbSNP
rs1419331984 85 dbSNP
rs978560207 86 dbSNP
rs867103190 91 dbSNP
rs1432081057 93 dbSNP
rs545726322 106 dbSNP
rs1020191022 108 dbSNP
rs988424286 120 dbSNP
rs988759611 127 dbSNP
rs578080863 130 dbSNP
rs1352478265 131 dbSNP
rs957047008 135 dbSNP
rs1221740759 147 dbSNP
rs1286064297 151 dbSNP
rs1032698549 154 dbSNP
rs1228407486 161 dbSNP
rs954505869 163 dbSNP
rs1030035853 164 dbSNP
rs1006596679 166 dbSNP
rs1462605795 168 dbSNP
rs570208461 171 dbSNP
rs889594074 174 dbSNP
rs1469773740 176 dbSNP
rs878917881 178 dbSNP
rs1413457605 183 dbSNP
rs879450499 199 dbSNP
rs13265547 200 dbSNP
rs17775790 201 dbSNP
rs752128520 203 dbSNP
rs897043147 207 dbSNP
rs1036978491 210 dbSNP
rs540696820 213 dbSNP
rs17775779 223 dbSNP
rs767279002 225 dbSNP
rs776212067 235 dbSNP
rs555079813 240 dbSNP
rs763616540 241 dbSNP
rs927440885 248 dbSNP
rs1005651490 255 dbSNP
rs561375734 256 dbSNP
rs1047750391 274 dbSNP
rs536630170 276 dbSNP
rs1218364886 280 dbSNP
rs1261025415 293 dbSNP
rs1406095523 299 dbSNP
rs895802480 301 dbSNP
rs1204246474 302 dbSNP
rs757158655 316 dbSNP
rs913458318 326 dbSNP
rs1179921713 327 dbSNP
rs989039495 332 dbSNP
rs1162772454 334 dbSNP
rs1473516012 335 dbSNP
rs1057167344 336 dbSNP
rs751465797 369 dbSNP
rs956996541 370 dbSNP
rs937335458 374 dbSNP
rs927325395 382 dbSNP
rs1389240403 388 dbSNP
rs1330320173 389 dbSNP
rs1317706570 396 dbSNP
rs978861313 410 dbSNP
rs1403982934 413 dbSNP
rs1281084235 416 dbSNP
rs1032647956 425 dbSNP
rs569682127 426 dbSNP
rs1467684261 430 dbSNP
rs1270705208 432 dbSNP
rs3836 435 dbSNP
rs953923840 436 dbSNP
rs1331870687 440 dbSNP
rs1337383354 441 dbSNP
rs539726943 449 dbSNP
rs565688201 450 dbSNP
rs1223585237 454 dbSNP
rs1371626494 456 dbSNP
rs1295571696 468 dbSNP
rs1437433147 476 dbSNP
rs1030668718 479 dbSNP
rs974395562 484 dbSNP
rs998412830 488 dbSNP
rs1458840241 489 dbSNP
rs1481664240 490 dbSNP
rs1200769899 503 dbSNP
rs185793677 504 dbSNP
rs763095459 508 dbSNP
rs182270813 509 dbSNP
rs1169099183 510 dbSNP
rs1396618183 517 dbSNP
rs1005483017 521 dbSNP
rs772028932 524 dbSNP
rs888401875 531 dbSNP
rs1005954010 537 dbSNP
rs1049089461 543 dbSNP
rs937382022 548 dbSNP
rs1426992113 564 dbSNP
rs1025852908 574 dbSNP
rs745793061 577 dbSNP
rs1250709458 580 dbSNP
rs896036389 594 dbSNP
rs1289945277 595 dbSNP
rs1490907146 602 dbSNP
rs1223595294 608 dbSNP
rs1464905055 611 dbSNP
rs1261506555 612 dbSNP
rs777611079 613 dbSNP
rs567746500 619 dbSNP
rs1373119485 625 dbSNP
rs1443552247 630 dbSNP
rs1161267912 632 dbSNP
rs1045829558 634 dbSNP
rs112066235 637 dbSNP
rs192260167 644 dbSNP
rs913403917 645 dbSNP
rs770912375 647 dbSNP
rs530806460 650 dbSNP
rs1383821412 658 dbSNP
rs1043151005 659 dbSNP
rs112435154 659 dbSNP
rs757008685 659 dbSNP
rs1370555651 662 dbSNP
rs1245269306 676 dbSNP
rs947490998 678 dbSNP
rs1361813836 679 dbSNP
rs1245832401 681 dbSNP
rs1301443877 686 dbSNP
rs1437369204 688 dbSNP
rs186146128 689 dbSNP
rs749258270 690 dbSNP
rs373717405 695 dbSNP
rs1461274870 702 dbSNP
rs528405299 704 dbSNP
rs933149976 719 dbSNP
rs1444841311 726 dbSNP
rs922314687 726 dbSNP
rs1361843176 728 dbSNP
rs1455204175 730 dbSNP
rs976533153 734 dbSNP
rs1433805617 736 dbSNP
rs974644634 739 dbSNP
rs964333151 744 dbSNP
rs908907178 745 dbSNP
rs961469206 750 dbSNP
rs1396797452 763 dbSNP
rs1015429183 767 dbSNP
rs950532242 778 dbSNP
rs1315494332 796 dbSNP
rs1190109541 797 dbSNP
rs1269196279 801 dbSNP
rs1323388985 810 dbSNP
rs1202378813 819 dbSNP
rs1026491594 820 dbSNP
rs994309791 839 dbSNP
rs1176250763 840 dbSNP
rs1247907013 841 dbSNP
rs960504170 842 dbSNP
rs1159518574 850 dbSNP
rs1428369555 855 dbSNP
rs1472046055 856 dbSNP
rs1449606223 861 dbSNP
rs545331773 862 dbSNP
rs1035920195 866 dbSNP
rs1005427738 867 dbSNP
rs1178552448 868 dbSNP
rs1408385024 881 dbSNP
rs1466669881 883 dbSNP
rs533702076 906 dbSNP
rs370225363 908 dbSNP
rs1033627527 914 dbSNP
rs866142285 923 dbSNP
rs1289350066 932 dbSNP
rs180917567 936 dbSNP
rs1046191038 945 dbSNP
rs1222215487 946 dbSNP
rs541213827 952 dbSNP
rs1313307706 957 dbSNP
rs1014347090 959 dbSNP
rs1347522436 967 dbSNP
rs1278535537 976 dbSNP
rs1230863495 977 dbSNP
rs1327149249 998 dbSNP
rs1481385356 1015 dbSNP
rs1182517531 1016 dbSNP
rs1267884571 1018 dbSNP
rs1294904505 1034 dbSNP
rs573926952 1048 dbSNP
rs1053214547 1049 dbSNP
rs936196868 1052 dbSNP
rs1409307397 1053 dbSNP
rs1381278979 1060 dbSNP
rs1043111833 1061 dbSNP
rs1352885924 1063 dbSNP
rs1011591117 1076 dbSNP
rs926194417 1079 dbSNP
rs1365324822 1086 dbSNP
rs891837364 1086 dbSNP
rs1050022126 1093 dbSNP
rs561446385 1099 dbSNP
rs1285584349 1103 dbSNP
rs1368864603 1107 dbSNP
rs1214527816 1108 dbSNP
rs933138872 1121 dbSNP
rs1308793315 1138 dbSNP
rs923125893 1156 dbSNP
rs1062312 1159 dbSNP
rs188129323 1161 dbSNP
rs758191382 1162 dbSNP
rs922301944 1174 dbSNP
rs976859172 1178 dbSNP
rs961114676 1180 dbSNP
rs1184750844 1182 dbSNP
rs908317649 1190 dbSNP
rs374323900 1193 dbSNP
rs531423722 1193 dbSNP
rs983944379 1198 dbSNP
rs1451469050 1205 dbSNP
rs1429967260 1208 dbSNP
rs1384764744 1210 dbSNP
rs1423005332 1212 dbSNP
rs1305285213 1213 dbSNP
rs1350885695 1214 dbSNP
rs1430610591 1219 dbSNP
rs575905523 1226 dbSNP
rs557735485 1233 dbSNP
rs952538273 1238 dbSNP
rs539322348 1242 dbSNP
rs1002128226 1244 dbSNP
rs970427488 1247 dbSNP
rs1313745322 1250 dbSNP
rs1356776806 1251 dbSNP
rs545983708 1255 dbSNP
rs1247747167 1260 dbSNP
rs1167738680 1267 dbSNP
rs1290288169 1283 dbSNP
rs1446277913 1301 dbSNP
rs572320422 1305 dbSNP
rs1243715969 1307 dbSNP
rs1465292875 1316 dbSNP
rs1424978766 1320 dbSNP
rs1384706769 1321 dbSNP
rs184234933 1323 dbSNP
rs1258873905 1334 dbSNP
rs1165264785 1335 dbSNP
rs748417844 1341 dbSNP
rs1414974900 1342 dbSNP
rs1400554554 1352 dbSNP
rs781533276 1353 dbSNP
rs1347395954 1363 dbSNP
rs1436504151 1370 dbSNP
rs1335434332 1383 dbSNP
rs1485581645 1384 dbSNP
rs1053159229 1396 dbSNP
rs1207608316 1402 dbSNP
rs1349518253 1403 dbSNP
rs1221786023 1413 dbSNP
rs1340359630 1422 dbSNP
rs1286119761 1427 dbSNP
rs2809 1432 dbSNP
rs1000290299 1436 dbSNP
rs950438219 1442 dbSNP
rs918991624 1445 dbSNP
rs1460092924 1447 dbSNP
rs535621698 1462 dbSNP
rs1050399106 1464 dbSNP
rs1323578599 1469 dbSNP
rs932911558 1481 dbSNP
rs960224729 1487 dbSNP
rs1414682917 1500 dbSNP
rs368213680 1512 dbSNP
rs1035886578 1513 dbSNP
rs922885322 1523 dbSNP
rs1040695818 1526 dbSNP
rs1403247663 1530 dbSNP
rs939699855 1532 dbSNP
rs1414071814 1540 dbSNP
rs908264746 1547 dbSNP
rs755395425 1560 dbSNP
rs1021885829 1564 dbSNP
rs931096318 1568 dbSNP
rs926483965 1571 dbSNP
rs761672605 1581 dbSNP
rs1410154711 1582 dbSNP
rs1281046412 1586 dbSNP
rs981045787 1587 dbSNP
rs796687242 1588 dbSNP
rs1261245595 1593 dbSNP
rs970665603 1600 dbSNP
rs751936244 1608 dbSNP
rs568306690 1609 dbSNP
rs1279464203 1614 dbSNP
rs1437412891 1615 dbSNP
rs1202756433 1616 dbSNP
rs956052401 1618 dbSNP
rs1031741774 1619 dbSNP
rs774131877 1623 dbSNP
rs181184371 1629 dbSNP
rs901673988 1630 dbSNP
rs1062315 1631 dbSNP
rs1395201925 1631 dbSNP
rs199990780 1632 dbSNP
rs1309545077 1633 dbSNP
rs554773226 1633 dbSNP
rs1416276155 1634 dbSNP
rs189204195 1635 dbSNP
rs1438693870 1636 dbSNP
rs775327845 1636 dbSNP
rs144154120 1639 dbSNP
rs1233910719 1643 dbSNP
rs928959760 1643 dbSNP
rs1275490891 1651 dbSNP
rs775902342 1652 dbSNP
rs1028489024 1660 dbSNP
rs1250160365 1662 dbSNP
rs918949680 1663 dbSNP
rs1194282890 1666 dbSNP
rs997447775 1672 dbSNP
rs1483506548 1678 dbSNP
rs1222158322 1679 dbSNP
rs1267237539 1680 dbSNP
rs1453806774 1681 dbSNP
rs991906469 1684 dbSNP
rs1489535590 1690 dbSNP
rs1273859513 1693 dbSNP
rs28485929 1696 dbSNP
rs980225470 1697 dbSNP
rs1301013772 1699 dbSNP
rs970230642 1700 dbSNP
rs1392679716 1705 dbSNP
rs185243020 1711 dbSNP
rs1317624852 1715 dbSNP
rs529438494 1716 dbSNP
rs193147676 1720 dbSNP
rs956047098 1723 dbSNP
rs866712897 1724 dbSNP
rs886778258 1726 dbSNP
rs1334939625 1732 dbSNP
rs1343074706 1734 dbSNP
rs543102286 1738 dbSNP
rs901902244 1739 dbSNP
rs576106948 1750 dbSNP
rs926402980 1752 dbSNP
rs1324668667 1756 dbSNP
rs544742955 1757 dbSNP
rs980610068 1761 dbSNP
rs1443611059 1772 dbSNP
rs1161325912 1776 dbSNP
rs949272258 1778 dbSNP
rs1458169406 1779 dbSNP
rs1157787099 1782 dbSNP
rs1382642689 1791 dbSNP
rs13123 1792 dbSNP
rs545767581 1814 dbSNP
rs988036048 1818 dbSNP
rs1366070521 1819 dbSNP
rs572098721 1828 dbSNP
rs897489940 1829 dbSNP
rs955999883 1835 dbSNP
rs1363563666 1838 dbSNP
rs1260541970 1842 dbSNP
rs1327642059 1848 dbSNP
rs1211177014 1849 dbSNP
rs1268175766 1854 dbSNP
rs1460542742 1858 dbSNP
rs1181228032 1863 dbSNP
rs1179979847 1871 dbSNP
rs555747278 1874 dbSNP
rs1253814517 1877 dbSNP
rs554103511 1880 dbSNP
rs1213162336 1881 dbSNP
rs1458716709 1884 dbSNP
rs1467144464 1889 dbSNP
rs978771890 1894 dbSNP
rs1056498836 1896 dbSNP
rs767404863 1898 dbSNP
rs1301174156 1904 dbSNP
rs1381569711 1906 dbSNP
rs190642869 1911 dbSNP
rs574640320 1917 dbSNP
rs556416023 1918 dbSNP
rs6921 1919 dbSNP
rs3203444 1923 dbSNP
rs901358599 1924 dbSNP
rs551613855 1929 dbSNP
rs1207364096 1940 dbSNP
rs1235091386 1943 dbSNP
rs1483359808 1946 dbSNP
rs138047141 1947 dbSNP
rs770732281 1960 dbSNP
rs1473482071 1961 dbSNP
rs1182652344 1963 dbSNP
rs1302164036 1968 dbSNP
rs1428433608 1970 dbSNP
rs1479436357 1978 dbSNP
rs1438084360 1981 dbSNP
rs745339690 1983 dbSNP
rs887391268 1985 dbSNP
rs1297890866 1999 dbSNP
rs1366726833 2004 dbSNP
rs914766869 2011 dbSNP
rs990414364 2019 dbSNP
rs1345381769 2024 dbSNP
rs1320910962 2027 dbSNP
rs1302720141 2028 dbSNP
rs1048087291 2031 dbSNP
rs1226220708 2047 dbSNP
rs565778612 2057 dbSNP
rs1483836858 2067 dbSNP
rs1205563312 2071 dbSNP
rs1267951839 2072 dbSNP
rs1031931537 2073 dbSNP
rs1436911667 2082 dbSNP
rs762969956 2082 dbSNP
rs1395928791 2083 dbSNP
rs904925887 2088 dbSNP
rs1433905953 2099 dbSNP
rs547643072 2102 dbSNP
rs553435014 2103 dbSNP
rs1431884672 2112 dbSNP
rs773142748 2116 dbSNP
rs140334150 2118 dbSNP
rs1434935401 2119 dbSNP
rs1062365 2121 dbSNP
rs897694586 2131 dbSNP
rs1193863697 2137 dbSNP
rs1056400881 2139 dbSNP
rs534500053 2159 dbSNP
rs1294811352 2161 dbSNP
rs1343800090 2169 dbSNP
rs1228754360 2173 dbSNP
rs1446392615 2176 dbSNP
rs1290719358 2186 dbSNP
rs1003180006 2188 dbSNP
rs904887562 2191 dbSNP
rs1201978291 2194 dbSNP
rs1485520111 2196 dbSNP
rs1044817297 2197 dbSNP
rs1246316470 2208 dbSNP
rs1052255522 2221 dbSNP
rs550239774 2226 dbSNP
rs1384983613 2228 dbSNP
rs796360279 2229 dbSNP
rs1167353076 2232 dbSNP
rs1350938739 2240 dbSNP
rs935247610 2241 dbSNP
rs1317937600 2257 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51582.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_148174 | 3UTR | AGCGUUUAAAAUAAAAUAUGCAACAAAAUGGAUGACUUAGUGGAGAUGGAAGCCCAUUAAUUGGGUUCCCCAUUAAAUCGUUUACAUACAAGAACACAGUUUUUAUACUAAGGAUUUGUGUUUAAAGUCUUGUAAAGUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000337198.5 | 3UTR | UUCCCCAUUAAAUCGUUUACAUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000337198.5 | 3UTR | UUCCCCAUUAAAUCGUUUACAUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000337198.5 | 3UTR | UUCCCCAUUAAAUCGUUUACAUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4677-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080553 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT089446 STAMBP STAM binding protein 2 2
MIRT135057 ADSS adenylosuccinate synthase 2 4
MIRT263519 RPS24 ribosomal protein S24 2 2
MIRT357966 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384298 GOLT1B golgi transport 1B 2 2
MIRT407003 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT442312 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443782 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446864 NBPF3 NBPF member 3 2 2
MIRT447642 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448464 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449117 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450240 TRIM66 tripartite motif containing 66 2 2
MIRT450265 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450682 RPN2 ribophorin II 2 2
MIRT465594 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT481118 AZIN1 antizyme inhibitor 1 2 4
MIRT497203 CDH7 cadherin 7 2 4
MIRT502954 CCNT2 cyclin T2 2 2
MIRT506337 NUP54 nucleoporin 54 2 4
MIRT509224 KIF14 kinesin family member 14 2 6
MIRT514595 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT515392 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525555 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525604 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533249 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535778 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535799 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT552784 YAF2 YY1 associated factor 2 2 2
MIRT556213 MB21D2 Mab-21 domain containing 2 2 2
MIRT558192 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT565809 SDCCAG3 serologically defined colon cancer antigen 3 2 2
MIRT566341 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT567792 DEK DEK proto-oncogene 2 2
MIRT572455 ZNF516 zinc finger protein 516 2 2
MIRT572582 HGFAC HGF activator 2 2
MIRT573357 PDE3A phosphodiesterase 3A 2 2
MIRT574649 LMAN2 lectin, mannose binding 2 2 2
MIRT608164 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610690 FAM89A family with sequence similarity 89 member A 2 2
MIRT618457 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT621924 SYAP1 synapse associated protein 1 2 4
MIRT622279 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624610 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631040 TAS2R30 taste 2 receptor member 30 2 2
MIRT636153 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT638255 SIX1 SIX homeobox 1 2 2
MIRT638330 RCAN1 regulator of calcineurin 1 2 2
MIRT641621 KIAA1244 ARFGEF family member 3 3 3
MIRT644556 SPOP speckle type BTB/POZ protein 2 2
MIRT645900 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT649115 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652244 TPI1 triosephosphate isomerase 1 2 2
MIRT657249 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT659857 CAPRIN1 cell cycle associated protein 1 2 4
MIRT665369 XIAP X-linked inhibitor of apoptosis 2 2
MIRT669214 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682579 CPA4 carboxypeptidase A4 2 2
MIRT698725 STX6 syntaxin 6 2 4
MIRT699788 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT700290 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT710374 LMBR1 limb development membrane protein 1 2 2
MIRT710407 YTHDC1 YTH domain containing 1 2 2
MIRT710569 TNPO1 transportin 1 2 2
MIRT711384 PLEKHG4B pleckstrin homology and RhoGEF domain containing G4B 2 2
MIRT712042 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT712717 NCAPG2 non-SMC condensin II complex subunit G2 2 2
MIRT713288 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT715649 USP6NL USP6 N-terminal like 2 2
MIRT716167 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716756 TRABD2A TraB domain containing 2A 2 2
MIRT718209 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718361 SOX1 SRY-box 1 2 2
MIRT718806 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719339 VGLL4 vestigial like family member 4 2 2
MIRT719671 SPDYE1 speedy/RINGO cell cycle regulator family member E1 2 2
MIRT720827 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT722184 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT722398 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT723460 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT724072 NCKAP1L NCK associated protein 1 like 2 2
MIRT724594 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT725234 PDE1B phosphodiesterase 1B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4677 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4677-5p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4677-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-4677-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)

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