miRTarBase - #MIRT481478


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pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARL8B   
Synonyms ARL10C, Gie1
Description ADP ribosylation factor like GTPase 8B
Transcript NM_018184   
Expression
Putative miRNA Targets on ARL8B
3'UTR of ARL8B
(miRNA target sites are highlighted)		 
>ARL8B|NM_018184|3'UTR
   1 AGCATCTCCTGAAGTCTTCCAGTCCTTCTTGGCTATAATCCTAGAATTATTGTCCGTTCCTCTGAAGTAATTCCCAGAAT
  81 ACGGTCCTTCCTAAACCCCAGAAATTGCCTTTTTCAGAGTTTATTTCTCATGTGCACTGCTGAAGATGAATATCCCTAAT
 161 CCTTCATAAAGAATCAGCTAGAGTTGTCATGATAAAGTCAGCACACACAAAAAGGCTTCTTACACATACCTGTCTTAAAC
 241 CATGTGTAGAGCTTTAAAAACAGAAAAAAAACCCCATATACTTATGACCATCTTAAATCAAGAAAATTGCATATTTCCAT
 321 TCTGGTCTTTCTGGGCCAGATTTTTATATTGGTTTTCAGTAAATGTCTATCTATAATATTTCATTATAGAGTCCAGTAGC
 401 TTAATACTGACACTGACTTGATACAGCATGAAGTTTCTAGTGCCACACACAGTATTTAGAAAACCTTTAGGCGTGAATGA
 481 CTCATGTGGGATATATGTAAACATAATGTTTATTTTATCTCACAAATGCATGTGAAATGTATAATTACATCTTAGGAATC
 561 CAAAATGGTCTGCAGAGAGTGAGCGGAGGCACCAGATCAATGTTGGTTCTTTGCACTGGTGAGATTCTGCCTGATGAATA
 641 TTAAAGATATCCTGCTTTCTGAGAACTCTATCACCAGATGGCAGTTGGGATATGGGAGGAACTAAAGCATCCTGTTTTGT
 721 ATCTGTCCAGATCATTATTTCTGTCTCTTGTTTTTTCTTCCTGGTTCAGGATACTTTTTTAAGGGGTTGAGAATTGAAGA
 801 TTTTCCAAAAGCGTTCATGAATTTAGAGCATTCCACCCAATATAATAAAACCTGTTAAGAATGTCAGTCTTTGTTCAAAC
 881 ATCTGTTTGTTCTATCTCCAGTCATTAAATCAGTGCTGCTGCATGACACTCTTAACTCCTGACTTTTTATATCCAGTCAT
 961 AAAGTTGACTTTCAGCACAAAAGATACTTATAAACAAATAAAAAATTTTTATTTTTCTCTCTTACTGATGTAAGCTTTGG
1041 CACTCTTTTGACTGGTGCCATTAGACATCTTGATTATTGTGACAACTCTAGACCTGCCTGCTTTATCTAATGTAATCATG
1121 CTCAATGTCTACAGGTTGTTTAATAATCAGTCACACAGAGAACTGAGGAACTGATGCTGTTTGTTTGCTTCTATGATACA
1201 GAGATGTCTAAAAACTTCAAATGGACATGTTTTGTAGTTTAGCGACTTCCGTATACATAAAGGGACATATTAATACTGGT
1281 TCATTTGTAAATTATTATTCATATAGACCACTGTAGTAGATAAAACTCTATGGTACACCTGCTTATGTGTTGCCTCACAC
1361 TGTGTGTGATTTTGTTTCTTTTGTTAAGCAGCACTTATGTAGACTGCATTTCCAAATGTGTTGAGCACTCAGAGTGTAGT
1441 CAACAGTAAGTTCTTTTAATGAATATCAGTTTTAATTTATAGACTGCCATGGCCTTAAAAATATTCTGTACAATATACTG
1521 CACTGTGTTGCACAGACACTACTTGCTTTTCTCCATTCATATTTTTATGAGTAGAATCTGGGCTTTTAAATTTCTCTTCT
1601 TATTCTTTGAAGCATGTTGCATACTACCCTGGTGGGATGGATGGTTCTGTAAATGAAGGGATATTTAAACTTGCTACTGT
1681 TGTTCAACACCATTAATGGTCAGTGTGAACCATTACAAAGAATGTGGCAACTTGCTTGTGCCTAAAAGGAGGAATTGGAA
1761 CTAGAATGTGTGACTCTGTGGGGACTGCATAGGTTTGTTAATTGACCTATAGCTAAACCTTAATGTGTTTGTGTGTCTAT
1841 ACATTGCTTTCCGCATTTCAAGACATCCAGACGCTATTACCAACATTTTCCTGTGCATTAACCTCTGCATGTGAAAACTT
1921 TTAACAGTTACTGAACTATGTAAATATGTGAATTTTTTTATTTAGGTGGATGCATTTTTTGTCTGTTTACTGCTCTTCTC
2001 AGCTTTATTCAATAAACTTGCATTTTAAGGGTTGTATTGGCAATTTTAACTTAAAATGTGCATCATGATGGAAGGTGCAG
2081 ACTTTTTTGGAAGTTTCCGAGAGGAGGGTCTATAGACCATTTGTCAGAAATCAGATCAGCCCTCAAAGAATGGGGTCTGT
2161 GGGCTAGTTAAAATAGAAATAAACTTTTAAAATATCCACAGAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgACAAG-GACGACUu 5'
             ||| | ||||||| 
Target 5' tcaTGTGCACTGCTGAa 3'
 128 - 144 149.00 -13.50
2 
miRNA  3' ucgacaAGGACGACuu 5'
                | ||||||  
Target 5' aatcagTGCTGCTGca 3'
 908 - 923 122.00 -8.50
3 
miRNA  3' ucGACAAG-GACGAcuu 5'
            |||||: |||||   
Target 5' gtCTGTTTACTGCTctt 3'
 1981 - 1997 118.00 -10.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM1593916 15 COSMIC
COSM1593915 22 COSMIC
COSM5202421 50 COSMIC
COSM9431309 55 COSMIC
COSN30113682 72 COSMIC
COSN30451157 76 COSMIC
COSN30184106 98 COSMIC
COSN16128965 176 COSMIC
COSN30131865 219 COSMIC
COSN29602730 272 COSMIC
COSN31562113 272 COSMIC
COSN20651111 273 COSMIC
COSN31491228 323 COSMIC
COSN31529196 351 COSMIC
COSN31541388 368 COSMIC
COSN26559831 378 COSMIC
COSN9721513 398 COSMIC
COSN25096991 747 COSMIC
COSN31544303 884 COSMIC
COSN31480593 1108 COSMIC
COSN31526403 1124 COSMIC
COSN31537742 1245 COSMIC
COSN16103289 1250 COSMIC
COSN26650545 1437 COSMIC
COSN5003393 1462 COSMIC
COSN19316671 1502 COSMIC
COSN22808319 1600 COSMIC
COSN31514774 1832 COSMIC
COSN7700479 1853 COSMIC
COSN31548178 1863 COSMIC
COSN31594829 1960 COSMIC
COSN20098077 2094 COSMIC
COSN31480768 2145 COSMIC
COSN31583237 2177 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750841442 1 dbSNP
rs1161760516 2 dbSNP
rs1413366375 5 dbSNP
rs1406238159 18 dbSNP
rs758935284 19 dbSNP
rs1358752589 21 dbSNP
rs1399424924 22 dbSNP
rs780463626 23 dbSNP
rs752542985 25 dbSNP
rs1326884083 33 dbSNP
rs769135845 36 dbSNP
rs1282269154 39 dbSNP
rs752366624 40 dbSNP
rs777371699 41 dbSNP
rs748882799 53 dbSNP
rs1293463314 56 dbSNP
rs115131604 57 dbSNP
rs1188325004 62 dbSNP
rs1445550236 65 dbSNP
rs1258721560 72 dbSNP
rs1183195511 73 dbSNP
rs546288848 83 dbSNP
rs772026456 84 dbSNP
rs1449182748 85 dbSNP
rs775243372 90 dbSNP
rs760701634 91 dbSNP
rs1272303699 97 dbSNP
rs1445593146 100 dbSNP
rs764015795 101 dbSNP
rs776709830 103 dbSNP
rs762004962 106 dbSNP
rs1159268172 108 dbSNP
rs1387213487 109 dbSNP
rs1402442830 120 dbSNP
rs1383194505 137 dbSNP
rs940357578 139 dbSNP
rs1313802948 146 dbSNP
rs1379768732 151 dbSNP
rs1229989754 162 dbSNP
rs750495291 163 dbSNP
rs1394482568 166 dbSNP
rs1378784806 167 dbSNP
rs1040131258 203 dbSNP
rs901565194 211 dbSNP
rs56317680 223 dbSNP
rs1368801637 227 dbSNP
rs1168449620 230 dbSNP
rs1425876608 231 dbSNP
rs1370528188 236 dbSNP
rs758594013 240 dbSNP
rs1209524563 241 dbSNP
rs372987676 243 dbSNP
rs893390778 244 dbSNP
rs1011858835 246 dbSNP
rs1183036577 248 dbSNP
rs914499547 260 dbSNP
rs1241340243 261 dbSNP
rs188538987 262 dbSNP
rs181573664 263 dbSNP
rs1002841357 264 dbSNP
rs755510556 269 dbSNP
rs1035779793 272 dbSNP
rs562244007 273 dbSNP
rs1307896924 278 dbSNP
rs1458093868 280 dbSNP
rs1348660771 286 dbSNP
rs1307538041 289 dbSNP
rs1023499101 290 dbSNP
rs1406062880 306 dbSNP
rs541168998 307 dbSNP
rs1389797451 312 dbSNP
rs1161818952 334 dbSNP
rs1457660899 338 dbSNP
rs1364752244 340 dbSNP
rs1390356454 341 dbSNP
rs779700883 349 dbSNP
rs1409088027 366 dbSNP
rs1180892819 367 dbSNP
rs200903833 368 dbSNP
rs1269460645 369 dbSNP
rs984762608 370 dbSNP
rs907774259 371 dbSNP
rs1268555645 373 dbSNP
rs748564394 383 dbSNP
rs1230425185 392 dbSNP
rs574968021 393 dbSNP
rs1327398775 409 dbSNP
rs1450056439 421 dbSNP
rs1277706443 427 dbSNP
rs1372604251 429 dbSNP
rs1332910773 430 dbSNP
rs542626858 439 dbSNP
rs1386729510 450 dbSNP
rs1290032008 461 dbSNP
rs975678971 465 dbSNP
rs1321631191 470 dbSNP
rs769396441 473 dbSNP
rs1386077389 474 dbSNP
rs369812591 484 dbSNP
rs1478033522 486 dbSNP
rs1378877089 487 dbSNP
rs1432558329 488 dbSNP
rs931703971 489 dbSNP
rs1210415647 497 dbSNP
rs1050585193 501 dbSNP
rs1444207012 505 dbSNP
rs1202608214 507 dbSNP
rs893327478 509 dbSNP
rs947536019 511 dbSNP
rs1201259468 521 dbSNP
rs1232799153 530 dbSNP
rs1347151915 531 dbSNP
rs1273186544 540 dbSNP
rs1233125278 542 dbSNP
rs1366623047 545 dbSNP
rs866332461 562 dbSNP
rs1433434610 563 dbSNP
rs1360158475 564 dbSNP
rs1184745317 566 dbSNP
rs1427678215 571 dbSNP
rs903397486 574 dbSNP
rs772891078 575 dbSNP
rs1171651933 576 dbSNP
rs1170344619 577 dbSNP
rs1465468669 581 dbSNP
rs544385491 585 dbSNP
rs1035665788 586 dbSNP
rs1190434940 587 dbSNP
rs563868455 590 dbSNP
rs748773336 595 dbSNP
rs185862163 604 dbSNP
rs1410396194 606 dbSNP
rs77699050 614 dbSNP
rs1343432024 615 dbSNP
rs984994389 618 dbSNP
rs190919506 619 dbSNP
rs1277311020 621 dbSNP
rs1226858999 625 dbSNP
rs1223066662 634 dbSNP
rs1275661174 635 dbSNP
rs149189748 636 dbSNP
rs528879223 637 dbSNP
rs1347478667 640 dbSNP
rs759326584 647 dbSNP
rs1212862743 649 dbSNP
rs1285192441 651 dbSNP
rs1272429733 664 dbSNP
rs1448264983 666 dbSNP
rs1014794734 667 dbSNP
rs1331616561 669 dbSNP
rs1413556110 670 dbSNP
rs117819224 671 dbSNP
rs1170355550 683 dbSNP
rs1207950744 684 dbSNP
rs1427773029 688 dbSNP
rs1389285386 693 dbSNP
rs975732965 694 dbSNP
rs767505448 697 dbSNP
rs775099928 700 dbSNP
rs953142452 722 dbSNP
rs1200104311 724 dbSNP
rs1187116488 730 dbSNP
rs34105324 730 dbSNP
rs182631176 731 dbSNP
rs766777903 742 dbSNP
rs1478834310 744 dbSNP
rs914272999 751 dbSNP
rs947583020 751 dbSNP
rs1165616013 762 dbSNP
rs760581365 764 dbSNP
rs1230449769 765 dbSNP
rs1389041785 774 dbSNP
rs1282004858 775 dbSNP
rs1354689987 775 dbSNP
rs186302873 791 dbSNP
rs1042255442 793 dbSNP
rs1309361409 794 dbSNP
rs1430271337 800 dbSNP
rs1407898064 807 dbSNP
rs1353921933 812 dbSNP
rs1170425774 813 dbSNP
rs542488238 814 dbSNP
rs938946962 832 dbSNP
rs765528301 835 dbSNP
rs894521036 837 dbSNP
rs1428924919 839 dbSNP
rs572931584 844 dbSNP
rs750726405 857 dbSNP
rs1342981437 863 dbSNP
rs1247729823 868 dbSNP
rs1231169399 873 dbSNP
rs1289654131 874 dbSNP
rs1329490890 875 dbSNP
rs1290210000 882 dbSNP
rs1226111221 884 dbSNP
rs1048480054 885 dbSNP
rs1438553547 886 dbSNP
rs1359429844 893 dbSNP
rs1210786800 895 dbSNP
rs1325024842 896 dbSNP
rs551622386 898 dbSNP
rs1452931333 900 dbSNP
rs1006069385 904 dbSNP
rs1190602668 907 dbSNP
rs1425983439 915 dbSNP
rs1193387265 919 dbSNP
rs1014681997 920 dbSNP
rs961839623 924 dbSNP
rs1246812384 926 dbSNP
rs1209814387 932 dbSNP
rs997411531 932 dbSNP
rs1190012797 944 dbSNP
rs1269556378 948 dbSNP
rs796912475 948 dbSNP
rs1030201581 953 dbSNP
rs1315761261 954 dbSNP
rs1383284763 957 dbSNP
rs191037023 961 dbSNP
rs1220847981 962 dbSNP
rs986162378 969 dbSNP
rs1302403132 974 dbSNP
rs914346230 977 dbSNP
rs1367107411 979 dbSNP
rs1318726056 984 dbSNP
rs564019185 992 dbSNP
rs968844630 996 dbSNP
rs977157594 1000 dbSNP
rs1178383792 1001 dbSNP
rs1413253191 1007 dbSNP
rs763113793 1014 dbSNP
rs1189780902 1016 dbSNP
rs1366280687 1019 dbSNP
rs1451658575 1020 dbSNP
rs1246600683 1021 dbSNP
rs866574379 1024 dbSNP
rs1485365248 1027 dbSNP
rs183020948 1028 dbSNP
rs1340362503 1030 dbSNP
rs1246201602 1034 dbSNP
rs938830470 1038 dbSNP
rs1229076431 1042 dbSNP
rs553146456 1045 dbSNP
rs1343986695 1046 dbSNP
rs143418261 1051 dbSNP
rs1381840244 1053 dbSNP
rs1267551673 1058 dbSNP
rs535475138 1060 dbSNP
rs1057414769 1061 dbSNP
rs1206363262 1062 dbSNP
rs916129948 1067 dbSNP
rs1374941304 1070 dbSNP
rs948748861 1084 dbSNP
rs751669037 1101 dbSNP
rs1189907381 1115 dbSNP
rs1388737318 1122 dbSNP
rs1170124107 1123 dbSNP
rs187644975 1124 dbSNP
rs1256336434 1126 dbSNP
rs1183230168 1128 dbSNP
rs1484434568 1133 dbSNP
rs1256161003 1136 dbSNP
rs888551391 1139 dbSNP
rs1483968505 1145 dbSNP
rs1249418505 1147 dbSNP
rs1226334219 1149 dbSNP
rs1423124379 1156 dbSNP
rs1188181684 1157 dbSNP
rs755387714 1166 dbSNP
rs1226798634 1171 dbSNP
rs1037057754 1177 dbSNP
rs897701460 1182 dbSNP
rs1308671484 1184 dbSNP
rs530511436 1185 dbSNP
rs1468407185 1188 dbSNP
rs1030209639 1194 dbSNP
rs1297966576 1198 dbSNP
rs1158217878 1200 dbSNP
rs1389623133 1201 dbSNP
rs1459054891 1207 dbSNP
rs1334740534 1210 dbSNP
rs1370545684 1217 dbSNP
rs1166526130 1223 dbSNP
rs781735988 1225 dbSNP
rs1474000192 1241 dbSNP
rs1416559428 1244 dbSNP
rs552164337 1245 dbSNP
rs953395202 1248 dbSNP
rs1397061352 1251 dbSNP
rs575511111 1252 dbSNP
rs1021739857 1256 dbSNP
rs1488712750 1267 dbSNP
rs1266954830 1268 dbSNP
rs1334574698 1269 dbSNP
rs544475820 1271 dbSNP
rs564356595 1274 dbSNP
rs968396810 1277 dbSNP
rs564076485 1289 dbSNP
rs1334375243 1293 dbSNP
rs577768060 1294 dbSNP
rs540369393 1297 dbSNP
rs1348700013 1305 dbSNP
rs1289416824 1310 dbSNP
rs1306980589 1313 dbSNP
rs1387830792 1314 dbSNP
rs1393373926 1318 dbSNP
rs559982200 1322 dbSNP
rs1329373182 1326 dbSNP
rs1210239986 1330 dbSNP
rs148364654 1331 dbSNP
rs992955250 1332 dbSNP
rs116458402 1335 dbSNP
rs1361536997 1337 dbSNP
rs562437441 1347 dbSNP
rs1200604735 1359 dbSNP
rs948954138 1361 dbSNP
rs984375989 1363 dbSNP
rs909897151 1369 dbSNP
rs1258163247 1381 dbSNP
rs1436056501 1382 dbSNP
rs1181146159 1387 dbSNP
rs940020487 1395 dbSNP
rs1348687855 1398 dbSNP
rs1037110091 1399 dbSNP
rs568746271 1413 dbSNP
rs531652806 1425 dbSNP
rs752756123 1427 dbSNP
rs1301711340 1428 dbSNP
rs1473667222 1431 dbSNP
rs933173817 1435 dbSNP
rs1366362109 1436 dbSNP
rs4685885 1444 dbSNP
rs192648932 1454 dbSNP
rs1051518618 1460 dbSNP
rs1157430344 1485 dbSNP
rs888942030 1490 dbSNP
rs1379226163 1496 dbSNP
rs571471384 1506 dbSNP
rs1007915362 1511 dbSNP
rs1248381413 1512 dbSNP
rs1190790922 1516 dbSNP
rs1445448871 1518 dbSNP
rs183387729 1524 dbSNP
rs188075747 1531 dbSNP
rs1201044363 1534 dbSNP
rs1347214732 1537 dbSNP
rs1278886906 1540 dbSNP
rs1343367638 1541 dbSNP
rs756519543 1545 dbSNP
rs1432485309 1551 dbSNP
rs1324259960 1552 dbSNP
rs1317021909 1553 dbSNP
rs1396169988 1554 dbSNP
rs1403699364 1555 dbSNP
rs1021541990 1560 dbSNP
rs1433986781 1561 dbSNP
rs192599834 1563 dbSNP
rs1170188040 1573 dbSNP
rs1436665264 1584 dbSNP
rs566837351 1595 dbSNP
rs749698073 1595 dbSNP
rs1394931580 1600 dbSNP
rs1188492930 1609 dbSNP
rs565058807 1620 dbSNP
rs777389094 1621 dbSNP
rs535871242 1622 dbSNP
rs1031427105 1627 dbSNP
rs1255449228 1629 dbSNP
rs555364491 1630 dbSNP
rs1352733923 1632 dbSNP
rs1277226866 1643 dbSNP
rs758516797 1649 dbSNP
rs993007385 1660 dbSNP
rs1269285637 1662 dbSNP
rs1311312994 1668 dbSNP
rs1233309535 1678 dbSNP
rs1023583744 1688 dbSNP
rs1482007199 1700 dbSNP
rs1204376449 1702 dbSNP
rs1414110850 1706 dbSNP
rs1371021667 1714 dbSNP
rs374084151 1724 dbSNP
rs1408060506 1732 dbSNP
rs984817673 1761 dbSNP
rs770576424 1764 dbSNP
rs910127935 1769 dbSNP
rs1415799056 1774 dbSNP
rs1297815903 1775 dbSNP
rs1266917489 1777 dbSNP
rs1473206398 1789 dbSNP
rs1254674020 1791 dbSNP
rs546397219 1792 dbSNP
rs1290991241 1796 dbSNP
rs1210090174 1799 dbSNP
rs972686652 1810 dbSNP
rs1212479273 1818 dbSNP
rs568227852 1820 dbSNP
rs922703062 1823 dbSNP
rs1178277445 1825 dbSNP
rs1371430495 1830 dbSNP
rs745406939 1831 dbSNP
rs575201045 1834 dbSNP
rs1169791602 1840 dbSNP
rs1373023348 1841 dbSNP
rs1392469099 1844 dbSNP
rs1403480891 1844 dbSNP
rs1457886857 1846 dbSNP
rs1410217638 1852 dbSNP
rs538150637 1853 dbSNP
rs1470033054 1854 dbSNP
rs1247674495 1867 dbSNP
rs888989668 1873 dbSNP
rs977265584 1880 dbSNP
rs1467415912 1890 dbSNP
rs1387021232 1891 dbSNP
rs1212660184 1892 dbSNP
rs1329291076 1894 dbSNP
rs377536139 1898 dbSNP
rs1285702519 1904 dbSNP
rs1302695534 1917 dbSNP
rs1222028709 1919 dbSNP
rs1339466621 1924 dbSNP
rs141156549 1937 dbSNP
rs577856764 1939 dbSNP
rs1368495506 1940 dbSNP
rs1043375839 1943 dbSNP
rs1436043579 1946 dbSNP
rs904399510 1948 dbSNP
rs1400644596 1951 dbSNP
rs1176065607 1953 dbSNP
rs1426571702 1953 dbSNP
rs1344303499 1961 dbSNP
rs1219072846 1963 dbSNP
rs775541692 1974 dbSNP
rs1252728208 1975 dbSNP
rs1192652089 1984 dbSNP
rs540453655 1986 dbSNP
rs1243358756 1987 dbSNP
rs1212949556 1994 dbSNP
rs895469133 1996 dbSNP
rs535315996 2013 dbSNP
rs1345513802 2015 dbSNP
rs142839616 2020 dbSNP
rs1022710653 2022 dbSNP
rs1436109928 2023 dbSNP
rs1364272498 2027 dbSNP
rs146922203 2033 dbSNP
rs137883539 2035 dbSNP
rs1359793395 2040 dbSNP
rs56118283 2053 dbSNP
rs1315413980 2061 dbSNP
rs1433359575 2063 dbSNP
rs149345761 2084 dbSNP
rs1017624630 2087 dbSNP
rs143599604 2091 dbSNP
rs59759123 2091 dbSNP
rs147463902 2092 dbSNP
rs1392547138 2094 dbSNP
rs961579964 2099 dbSNP
rs972946461 2108 dbSNP
rs922629855 2109 dbSNP
rs1279352084 2114 dbSNP
rs1164465841 2117 dbSNP
rs1309028867 2119 dbSNP
rs1293770164 2120 dbSNP
rs1214175794 2139 dbSNP
rs1380020867 2149 dbSNP
rs1295153163 2152 dbSNP
rs1413487084 2155 dbSNP
rs955374222 2167 dbSNP
rs1309169923 2168 dbSNP
rs147163933 2174 dbSNP
rs1353093844 2184 dbSNP
rs1167924493 2185 dbSNP
rs911277505 2196 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_018184 | 3UTR | AUACGGUCCUUCCUAAACCCCAGAAAUUGCCUUUUUCAGAGUUUAUUUCUCAUGUGCACUGCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_018184 | 3UTR | CCCAGAAAUUGCCUUUUUCAGAGUUUAUUUCUCAUGUGCACUGCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_018184 | 3UTR | UCCUGAAGUCUUCCAGUCCUUCUUGGCUAUAAUCCUAGAAUUAUUGUCCGUUCCUCUGAAGUAAUUCCCAGAAUACGGUCCUUCCUAAACCCCAGAAAUUGCCUUUUUCAGAGUUUAUUUCUCAUGUGCACUGCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_018184 | 3UTR | CCCAGAAAUUGCCUUUUUCAGAGUUUAUUUCUCAUGUGCACUGCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_018184 | 3UTR | CCAGAAUACGGUCCUUCCUAAACCCCAGAAAUUGCCUUUUUCAGAGUUUAUUUCUCAUGUGCACUGCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_018184 | 3UTR | GCUGAAGAUGAAUAUCCCUAAUCCUUCAUAAAGAAUCAGCUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000419534.2 | 3UTR | UUUAUUUCUCAUGUGCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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