pre-miRNA Information
pre-miRNA hsa-mir-520g   
Genomic Coordinates chr19: 53722166 - 53722255
Description Homo sapiens miR-520g stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-520g-3p
Sequence 55| ACAAAGUGCUUCCCUUUAGAGUGU |78
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1323826229 2 dbSNP
rs755388007 3 dbSNP
rs1164244906 6 dbSNP
rs1246278474 7 dbSNP
rs765799681 8 dbSNP
rs753182219 9 dbSNP
rs572746807 17 dbSNP
rs1384883413 18 dbSNP
rs1439199232 20 dbSNP
rs780750635 21 dbSNP
rs745461502 22 dbSNP
rs370035590 23 dbSNP
rs1017282550 24 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol APEX1   
Synonyms APE, APE1, APEN, APEX, APX, HAP1, REF1
Description apurinic/apyrimidinic endodeoxyribonuclease 1
Transcript NM_001641   
Other Transcripts NM_080648 , NM_080649   
Expression
Putative miRNA Targets on APEX1
3'UTR of APEX1
(miRNA target sites are highlighted)
>APEX1|NM_001641|3'UTR
   1 CACCACCCCTAAATCACTTTGAGCCTGGGAAATAAGCCCCCTCAACTACCATTCCTTCTTTAAACACTCTTCAGAGAAAT
  81 CTGCATTCTATTTCTCATGTATAAAACTAGGAATCCTCCAACCAGGCTCCTGTGATAGAGTTCTTTTAAGCCCAAGATTT
 161 TTTATTTGAGGGTTTTTTGTTTTTTAAAAAAAAATTGAACAAAGACTACTAATGACTTTGTTTGAATTATCCACATGAAA
 241 ATAAAGAGCCATAGTTTCAGCCTTAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uguGAGAUUUCCCUUCGUGAAACa 5'
             | |||     || ||||||| 
Target 5' cacCCCTA-----AATCACTTTGa 3'
4 - 22 148.00 -8.30
2
miRNA  3' ugUGA-GAUUUCCCUUCGUGAAACa 5'
            ||| |||| |      |||||| 
Target 5' agACTACTAATG------ACTTTGt 3'
203 - 221 125.00 -6.90
3
miRNA  3' ugUGAGAUUUCCCUU----CGUGAAAca 5'
            |||||  || |||    |||:| |  
Target 5' acACTCTTCAGAGAAATCTGCATTCTat 3'
64 - 91 104.00 -12.96
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30168709 4 COSMIC
COSN20078120 66 COSMIC
COSN1639515 70 COSMIC
COSN30134914 77 COSMIC
COSN31531919 84 COSMIC
COSN30447950 130 COSMIC
COSN8588396 158 COSMIC
COSN31590643 164 COSMIC
COSN30608908 186 COSMIC
COSN8140352 187 COSMIC
COSN28838135 195 COSMIC
COSN16743853 215 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1301652270 2 dbSNP
rs17112002 3 dbSNP
rs774168347 4 dbSNP
rs1043739629 7 dbSNP
rs1288511432 8 dbSNP
rs12590363 10 dbSNP
rs904741245 14 dbSNP
rs761809761 16 dbSNP
rs942701110 16 dbSNP
rs759225207 19 dbSNP
rs767141318 20 dbSNP
rs1470896360 25 dbSNP
rs752091024 28 dbSNP
rs755638723 33 dbSNP
rs765357238 37 dbSNP
rs1278129567 38 dbSNP
rs764007376 42 dbSNP
rs1485351842 44 dbSNP
rs773464873 47 dbSNP
rs753786698 49 dbSNP
rs193287013 50 dbSNP
rs1282903014 51 dbSNP
rs1211308283 58 dbSNP
rs1436760908 70 dbSNP
rs1179087518 71 dbSNP
rs901275905 83 dbSNP
rs959487488 86 dbSNP
rs1047115775 91 dbSNP
rs1172623581 101 dbSNP
rs1413161887 108 dbSNP
rs1394918746 110 dbSNP
rs1433224653 111 dbSNP
rs1357648711 112 dbSNP
rs1314465553 116 dbSNP
rs1448509420 118 dbSNP
rs1344492447 119 dbSNP
rs1156842287 122 dbSNP
rs1401880520 124 dbSNP
rs573714948 127 dbSNP
rs1022831389 128 dbSNP
rs1474002496 132 dbSNP
rs1005375385 135 dbSNP
rs1182766242 137 dbSNP
rs1491542509 137 dbSNP
rs1491462675 138 dbSNP
rs1391275168 141 dbSNP
rs1326945243 148 dbSNP
rs540658996 152 dbSNP
rs376939375 154 dbSNP
rs756927677 158 dbSNP
rs1272594567 159 dbSNP
rs1231584626 161 dbSNP
rs923950459 167 dbSNP
rs1001883961 173 dbSNP
rs1228607447 176 dbSNP
rs1803119 180 dbSNP
rs955582331 185 dbSNP
rs1034713911 186 dbSNP
rs1049498 186 dbSNP
rs1389335436 186 dbSNP
rs3189662 187 dbSNP
rs987929416 196 dbSNP
rs185469522 202 dbSNP
rs1419489100 206 dbSNP
rs561523887 210 dbSNP
rs1338690446 212 dbSNP
rs1427621314 217 dbSNP
rs546055483 217 dbSNP
rs1417809810 220 dbSNP
rs913647663 224 dbSNP
rs564462170 236 dbSNP
rs780926903 239 dbSNP
rs967960316 253 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000557054.1 | 3UTR | cggcagugaucacuguccuaucacccuauaccuagcacugugaCACCACCCCUAAAUCACUUUGAGCCUGGGAAAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.455 0.05 0.367 0.1 14 Click to see details
HNSC -0.289 0.26 -0.143 0.38 7 Click to see details
LIHC 0.319 0.4 0.500 0.33 3 Click to see details
LIHC 0.319 0.4 0.500 0.33 3 Click to see details
LIHC 0.319 0.4 0.500 0.33 3 Click to see details
LIHC 0.319 0.4 0.500 0.33 3 Click to see details
362 hsa-miR-520g-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004276 VEGFA vascular endothelial growth factor A 2 1
MIRT061377 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT070863 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT074319 TNRC6A trinucleotide repeat containing 6A 2 4
MIRT081126 LDLR low density lipoprotein receptor 2 6
MIRT093444 MSMO1 methylsterol monooxygenase 1 2 2
MIRT103397 CBX3 chromobox 3 2 2
MIRT107536 VLDLR very low density lipoprotein receptor 2 2
MIRT109624 KLHL15 kelch like family member 15 2 4
MIRT119717 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT130126 TXNIP thioredoxin interacting protein 2 2
MIRT133699 SKI SKI proto-oncogene 2 2
MIRT140155 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT153990 PRNP prion protein 2 2
MIRT161898 FXR1 FMR1 autosomal homolog 1 2 2
MIRT164670 WHSC1 nuclear receptor binding SET domain protein 2 2 4
MIRT178073 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT193026 TMOD3 tropomodulin 3 2 2
MIRT216879 MSH3 mutS homolog 3 2 2
MIRT230977 PRRG4 proline rich and Gla domain 4 2 2
MIRT242752 FNBP1L formin binding protein 1 like 2 2
MIRT249018 PABPC3 poly(A) binding protein cytoplasmic 3 2 8
MIRT254769 XRCC6 X-ray repair cross complementing 6 2 6
MIRT266862 SLC25A44 solute carrier family 25 member 44 2 2
MIRT275453 TMPO thymopoietin 2 2
MIRT285530 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT286959 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT301219 SH3BP4 SH3 domain binding protein 4 2 2
MIRT325706 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT437832 SMAD7 SMAD family member 7 3 1
MIRT442639 TBC1D12 TBC1 domain family member 12 2 2
MIRT443433 MAPT microtubule associated protein tau 2 2
MIRT446289 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT447962 WDR77 WD repeat domain 77 2 2
MIRT454271 PSMA1 proteasome subunit alpha 1 2 2
MIRT454809 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT456031 CRYZ crystallin zeta 2 8
MIRT462068 CCDC77 coiled-coil domain containing 77 2 4
MIRT463549 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT470351 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT474452 KLHL11 kelch like family member 11 2 10
MIRT476644 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT481110 B2M beta-2-microglobulin 2 2
MIRT481790 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT482106 AKT3 AKT serine/threonine kinase 3 2 4
MIRT482526 ACTB actin beta 2 4
MIRT485571 FOXQ1 forkhead box Q1 2 2
MIRT486010 LPAR2 lysophosphatidic acid receptor 2 2 2
MIRT493607 HMGB3 high mobility group box 3 2 6
MIRT495181 MUC20 mucin 20, cell surface associated 2 2
MIRT496046 MORC1 MORC family CW-type zinc finger 1 2 2
MIRT496734 TRIM31 tripartite motif containing 31 2 2
MIRT497421 FAM46A family with sequence similarity 46 member A 2 2
MIRT497493 RGS17 regulator of G protein signaling 17 2 2
MIRT497751 OXGR1 oxoglutarate receptor 1 2 2
MIRT498355 ABHD17B abhydrolase domain containing 17B 2 2
MIRT501454 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501584 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT501781 NRBF2 nuclear receptor binding factor 2 2 6
MIRT506503 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507414 ELK4 ELK4, ETS transcription factor 2 2
MIRT508557 CEP72 centrosomal protein 72 2 4
MIRT508726 ZNF682 zinc finger protein 682 2 4
MIRT508762 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT508818 GPR155 G protein-coupled receptor 155 2 2
MIRT509112 BMP8B bone morphogenetic protein 8b 2 6
MIRT509273 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT511537 HMGB1 high mobility group box 1 2 6
MIRT514118 SERF2 small EDRK-rich factor 2 2 2
MIRT514302 FXYD5 FXYD domain containing ion transport regulator 5 2 6
MIRT514962 SIGLEC11 sialic acid binding Ig like lectin 11 2 2
MIRT515557 TMEM134 transmembrane protein 134 2 2
MIRT516042 MED18 mediator complex subunit 18 2 2
MIRT516540 MIXL1 Mix paired-like homeobox 2 2
MIRT516992 COX19 COX19, cytochrome c oxidase assembly factor 2 4
MIRT517169 SLC28A1 solute carrier family 28 member 1 2 2
MIRT517242 PRIM1 DNA primase subunit 1 2 4
MIRT517722 KIF1C kinesin family member 1C 2 2
MIRT517797 EFCAB11 EF-hand calcium binding domain 11 2 4
MIRT517997 SLC16A13 solute carrier family 16 member 13 2 2
MIRT518033 ABHD15 abhydrolase domain containing 15 2 4
MIRT518843 NEK8 NIMA related kinase 8 2 2
MIRT518874 NKD1 naked cuticle homolog 1 2 2
MIRT520138 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT521531 QSOX1 quiescin sulfhydryl oxidase 1 2 4
MIRT522855 KIAA1551 KIAA1551 2 2
MIRT522976 INTU inturned planar cell polarity protein 2 2
MIRT523064 HYPK huntingtin interacting protein K 2 2
MIRT523421 GPR157 G protein-coupled receptor 157 2 2
MIRT524077 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT524277 CYCS cytochrome c, somatic 2 2
MIRT524326 CRLF3 cytokine receptor like factor 3 2 4
MIRT524374 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524439 CNKSR3 CNKSR family member 3 2 2
MIRT524756 BCL2L2 BCL2 like 2 2 2
MIRT526621 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT529610 H1F0 H1 histone family member 0 2 2
MIRT529984 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 6
MIRT530605 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT531759 TXK TXK tyrosine kinase 2 4
MIRT532031 FHDC1 FH2 domain containing 1 2 2
MIRT532107 RRP8 ribosomal RNA processing 8 2 2
MIRT532920 ZNF385A zinc finger protein 385A 2 2
MIRT533005 ZFHX3 zinc finger homeobox 3 2 4
MIRT533102 YOD1 YOD1 deubiquitinase 2 2
MIRT534262 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534458 SCML2 Scm polycomb group protein like 2 2 4
MIRT534982 PRR11 proline rich 11 2 2
MIRT536679 IKZF5 IKAROS family zinc finger 5 2 2
MIRT537431 FBXL7 F-box and leucine rich repeat protein 7 2 2
MIRT538035 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT539717 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT540260 FAM89A family with sequence similarity 89 member A 2 2
MIRT540372 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT540519 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540651 ZNF514 zinc finger protein 514 2 2
MIRT540921 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT541156 PABPC1 poly(A) binding protein cytoplasmic 1 2 4
MIRT541745 ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 2 2
MIRT542029 PEX2 peroxisomal biogenesis factor 2 2 2
MIRT542036 PTRF caveolae associated protein 1 2 2
MIRT542127 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 2
MIRT542252 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT542354 MED16 mediator complex subunit 16 2 2
MIRT542466 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT542505 WDR13 WD repeat domain 13 2 2
MIRT542712 RPS15A ribosomal protein S15a 2 2
MIRT542958 FOXK1 forkhead box K1 2 2
MIRT543179 FICD FIC domain containing 2 2
MIRT552884 WASL Wiskott-Aldrich syndrome like 2 4
MIRT554997 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555187 PRUNE2 prune homolog 2 2 2
MIRT555236 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT555451 POLR3A RNA polymerase III subunit A 2 2
MIRT557811 FOXO1 forkhead box O1 2 4
MIRT558161 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT558753 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT558765 CFL2 cofilin 2 2 2
MIRT559114 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT561823 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT562486 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT566139 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT566951 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT566965 LBR lamin B receptor 2 2
MIRT567845 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT568209 CAV1 caveolin 1 2 2
MIRT568398 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT569177 DMD dystrophin 2 2
MIRT570687 FZD5 frizzled class receptor 5 2 2
MIRT572245 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT572662 AGMAT agmatinase 2 4
MIRT575209 Piwil2 piwi-like RNA-mediated gene silencing 2 2 5
MIRT575985 Fem1a feminization 1 homolog a (C. elegans) 2 5
MIRT606843 FEM1A fem-1 homolog A 2 7
MIRT608364 PIWIL2 piwi like RNA-mediated gene silencing 2 2 7
MIRT608734 MYH9 myosin heavy chain 9 2 2
MIRT612598 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT614247 WDR53 WD repeat domain 53 2 4
MIRT615162 SPIB Spi-B transcription factor 2 2
MIRT615467 BNC2 basonuclin 2 2 2
MIRT615812 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT619490 QSOX2 quiescin sulfhydryl oxidase 2 2 2
MIRT619825 POLM DNA polymerase mu 2 4
MIRT623527 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT624353 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT625978 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT626207 PNRC1 proline rich nuclear receptor coactivator 1 2 4
MIRT626915 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT628563 MELK maternal embryonic leucine zipper kinase 2 2
MIRT630116 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT631328 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT631514 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT633106 CBX5 chromobox 5 2 2
MIRT634084 APOH apolipoprotein H 2 2
MIRT634644 HIP1 huntingtin interacting protein 1 2 4
MIRT634941 GTF2H2C GTF2H2 family member C 2 4
MIRT639434 PKP1 plakophilin 1 2 2
MIRT640365 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT640717 CEP68 centrosomal protein 68 2 2
MIRT641216 TRIB1 tribbles pseudokinase 1 2 4
MIRT642272 SMIM17 small integral membrane protein 17 2 2
MIRT644010 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT645145 CUBN cubilin 2 2
MIRT645199 POLR3F RNA polymerase III subunit F 2 2
MIRT653159 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT654474 RANBP2 RAN binding protein 2 2 2
MIRT656176 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT658856 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT662111 LACTB lactamase beta 2 2
MIRT662393 ICA1L islet cell autoantigen 1 like 2 4
MIRT663405 SYT17 synaptotagmin 17 2 2
MIRT663852 LEPROTL1 leptin receptor overlapping transcript like 1 2 2
MIRT663934 ZNF554 zinc finger protein 554 2 2
MIRT664214 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT664379 CYB5A cytochrome b5 type A 2 2
MIRT672156 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 2 2
MIRT673120 MFSD2A major facilitator superfamily domain containing 2A 2 2
MIRT676082 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676772 SNX2 sorting nexin 2 2 2
MIRT677106 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677142 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT677247 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677591 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 2 2
MIRT678311 NPHS1 NPHS1, nephrin 2 2
MIRT678528 P2RX7 purinergic receptor P2X 7 2 2
MIRT678732 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT679619 RRP36 ribosomal RNA processing 36 2 2
MIRT680134 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT680358 GATAD1 GATA zinc finger domain containing 1 2 4
MIRT680685 ZNF785 zinc finger protein 785 2 2
MIRT681824 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT683315 C19orf40 Fanconi anemia core complex associated protein 24 1 1
MIRT683384 ESR2 estrogen receptor 2 2 2
MIRT683490 ZNF7 zinc finger protein 7 2 2
MIRT683522 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT683687 MICA MHC class I polypeptide-related sequence A 2 2
MIRT683871 OCIAD1 OCIA domain containing 1 2 2
MIRT683942 MYLK3 myosin light chain kinase 3 2 2
MIRT683973 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT684048 FOLR1 folate receptor 1 2 2
MIRT684078 TLR7 toll like receptor 7 2 2
MIRT684130 CEP104 centrosomal protein 104 2 2
MIRT684356 BCAS4 breast carcinoma amplified sequence 4 2 2
MIRT684489 GPR137B G protein-coupled receptor 137B 2 2
MIRT684570 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT684613 GTF2IRD2B GTF2I repeat domain containing 2B 2 2
MIRT684645 PDE4C phosphodiesterase 4C 2 2
MIRT684709 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT684740 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT684783 MYO1F myosin IF 2 2
MIRT684917 CD28 CD28 molecule 2 2
MIRT685193 DCTN5 dynactin subunit 5 2 2
MIRT685242 F2RL1 F2R like trypsin receptor 1 2 2
MIRT685312 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT685349 CCL5 C-C motif chemokine ligand 5 2 2
MIRT685574 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT685630 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT685658 C11orf1 chromosome 11 open reading frame 1 2 2
MIRT685707 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT685737 C12orf65 chromosome 12 open reading frame 65 2 2
MIRT685779 ZNF426 zinc finger protein 426 2 2
MIRT685879 RTN2 reticulon 2 2 2
MIRT685951 PTGIS prostaglandin I2 synthase 2 2
MIRT686103 TNIP3 TNFAIP3 interacting protein 3 2 2
MIRT686152 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT686281 WWC1 WW and C2 domain containing 1 2 2
MIRT686319 VPS53 VPS53, GARP complex subunit 2 2
MIRT686359 USP15 ubiquitin specific peptidase 15 2 2
MIRT686388 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT686440 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT686523 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT686692 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT686823 SLC7A11 solute carrier family 7 member 11 2 2
MIRT686879 SLC1A5 solute carrier family 1 member 5 2 2
MIRT686912 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT687042 RNF115 ring finger protein 115 2 2
MIRT687075 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT687250 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT687401 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT687498 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT687645 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT687856 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT687927 HOOK3 hook microtubule tethering protein 3 2 2
MIRT687979 GTF2IRD2 GTF2I repeat domain containing 2 2 2
MIRT688110 GK5 glycerol kinase 5 (putative) 2 2
MIRT688121 GEMIN8 gem nuclear organelle associated protein 8 2 2
MIRT688213 FKBP14 FK506 binding protein 14 2 2
MIRT688270 FAM213A family with sequence similarity 213 member A 2 2
MIRT688465 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT688503 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT688633 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT688676 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT688826 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT689122 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT689170 ZNF665 zinc finger protein 665 2 2
MIRT689795 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT689842 HIST1H2BJ histone cluster 1 H2B family member j 2 2
MIRT690364 RPL37A ribosomal protein L37a 2 2
MIRT690736 IRAK4 interleukin 1 receptor associated kinase 4 2 2
MIRT690982 ZNF578 zinc finger protein 578 2 2
MIRT691073 NUGGC nuclear GTPase, germinal center associated 2 2
MIRT691328 KIAA1841 KIAA1841 2 2
MIRT691493 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT691575 CCDC125 coiled-coil domain containing 125 2 2
MIRT692069 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT692105 CXorf38 chromosome X open reading frame 38 2 4
MIRT692209 NOL9 nucleolar protein 9 2 2
MIRT692319 RFK riboflavin kinase 2 2
MIRT692380 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT692441 METTL8 methyltransferase like 8 2 2
MIRT692542 PARD3 par-3 family cell polarity regulator 2 2
MIRT692605 GDF5OS growth differentiation factor 5 opposite strand 2 2
MIRT692786 SYNPO2L synaptopodin 2 like 2 2
MIRT692816 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT692877 RBM41 RNA binding motif protein 41 2 2
MIRT692988 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693195 MKI67 marker of proliferation Ki-67 2 2
MIRT693350 RNF34 ring finger protein 34 2 2
MIRT694107 ZNF446 zinc finger protein 446 2 2
MIRT694194 ZNF347 zinc finger protein 347 2 2
MIRT694661 C14orf119 chromosome 14 open reading frame 119 2 2
MIRT694815 STX4 syntaxin 4 2 2
MIRT694935 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT695181 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695617 VBP1 VHL binding protein 1 2 2
MIRT695661 MAN2B2 mannosidase alpha class 2B member 2 2 2
MIRT695832 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT695923 ZNF174 zinc finger protein 174 2 2
MIRT695973 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT696184 GNB5 G protein subunit beta 5 2 2
MIRT696444 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT696861 UBOX5 U-box domain containing 5 2 2
MIRT696905 C14orf105 coiled-coil domain containing 198 2 2
MIRT697247 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697392 ZMAT3 zinc finger matrin-type 3 2 2
MIRT697984 TSPAN6 tetraspanin 6 2 2
MIRT698331 TMEM127 transmembrane protein 127 2 2
MIRT699267 SLC6A4 solute carrier family 6 member 4 2 2
MIRT699318 SLC35F5 solute carrier family 35 member F5 2 4
MIRT699634 SH3BP5 SH3 domain binding protein 5 2 2
MIRT699697 SF3B3 splicing factor 3b subunit 3 2 2
MIRT699768 SEMA4D semaphorin 4D 2 2
MIRT700047 RPL14 ribosomal protein L14 2 2
MIRT700104 RNF19B ring finger protein 19B 2 2
MIRT701110 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT701296 NUDT3 nudix hydrolase 3 2 2
MIRT702050 METTL21A methyltransferase like 21A 2 2
MIRT702088 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT702381 KLF10 Kruppel like factor 10 2 2
MIRT702526 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT702582 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT702945 HIPK3 homeodomain interacting protein kinase 3 2 2
MIRT703093 GPRIN3 GPRIN family member 3 2 2
MIRT704010 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT704112 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT704147 DNAL1 dynein axonemal light chain 1 2 2
MIRT704197 LDHD lactate dehydrogenase D 2 2
MIRT704445 CTNNB1 catenin beta 1 2 2
MIRT704764 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT705084 C4orf29 abhydrolase domain containing 18 2 2
MIRT705350 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT706108 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT706278 SLC35F6 solute carrier family 35 member F6 2 2
MIRT706313 CCDC30 coiled-coil domain containing 30 2 2
MIRT706353 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT706403 HAS2 hyaluronan synthase 2 2 2
MIRT706516 MTMR9 myotubularin related protein 9 2 2
MIRT707828 TMEM133 transmembrane protein 133 2 2
MIRT708370 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 2
MIRT708450 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT708513 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT709074 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT709507 RHOH ras homolog family member H 2 2
MIRT709539 ZBED1 zinc finger BED-type containing 1 2 2
MIRT711774 RFXAP regulatory factor X associated protein 2 2
MIRT714309 ZNF454 zinc finger protein 454 2 2
MIRT719073 ACOX1 acyl-CoA oxidase 1 2 2
MIRT719105 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2 2
MIRT719420 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT722311 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT724552 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT737294 MYO18B myosin XVIIIB 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-520g Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-520g Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-520g-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-520g-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-520g-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-520g-3p Cisplatin 5460033 NSC119875 approved resistant Low Epithelial Ovarian Cancer cell line (A2780)
hsa-miR-520g-3p Paclitaxel 36314 NSC125973 approved resistant Low Epithelial Ovarian Cancer cell line (A2780)
hsa-miR-520g-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (500nM)
hsa-miR-520g-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (500nM)
hsa-miR-520g-3p Bortezomib 387447 NSC681239 approved sensitive Low Multiple Myeloma cell line (RPMI-8266, H929)
hsa-miR-520g-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-520g-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-520g-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-520g-3p Paclitaxel 36314 NSC125973 approved resistant cell line (HS578T)
hsa-miR-520g-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-520g-3p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-520g-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-520g-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-520g-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (T24)
hsa-miR-520g-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-520g-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-520g-3p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)
hsa-miR-520g-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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