miRTarBase - #MIRT481811


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pre-miRNA Information
pre-miRNA hsa-mir-215   
Genomic Coordinates chr1: 220117853 - 220117962
Synonyms MIRN215, miRNA215, mir-215, MIR215
Description Homo sapiens miR-215 stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-215-3p
Sequence 64| UCUGUCAUUUCUUUAGGCCAAUA |86
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768393822 2 dbSNP
rs1345487830 5 dbSNP
rs757646667 7 dbSNP
rs754286532 11 dbSNP
rs749489380 17 dbSNP
rs1333471638 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AP4E1   
Synonyms CPSQ4, SPG51, STUT1
Description adaptor related protein complex 4 epsilon 1 subunit
Transcript NM_007347   
Expression
Putative miRNA Targets on AP4E1
3'UTR of AP4E1
(miRNA target sites are highlighted)		 
>AP4E1|NM_007347|3'UTR
   1 CAGAAGCCCTGCTAAATTTTACTCCATCAAGATCAATGGTTTACATAGATAAACTTATTTACCAAAGTAAAAAGAACTCA
  81 TGGTACTTCTAATGAAAATGGGGATTATTACAAGTGTGGTTTATATGTTTTCTTTGTGATTCCTGGTCAAGAAAGATCCC
 161 CAAAACTGTATCCCTAACCTTTAACTCAGGATTGTACAGTATGTTTAGGTCCCTCAAAAAGTGACCTAAGCTAATGTTAT
 241 AAACTGCTAATGATTTATATATCACTTAGTGTGTAGAGGGACTGAAAATATTTATTTTGTTATAAATAATTTTATAGCAC
 321 GTTTACTCTAGTGCTAGCTAATTTGTAATAAAGCCAAGTCTCAGTTTTCTGCATTAAATGGAAGGGAGACATGAAATTGA
 401 TAATCTCAAACTTAATTCATATTTGGCTTTGGAATGTAGTGTATGGTTTTTGGTAGGGAAGTCAATATTTTCGATTATGT
 481 TTTGCTTAGATCAGTGTTGAACTAAGTTGGCATAGCACACACTAACAGTTGTAGGAGATCCATGAGCATGCTGGATATTG
 561 AGGGGATCCAATCTGTGATCTATTTTTTATTATAGATAACTGTTACACATAATTTCAGATCGTTTGGCTGTAAAATTTGT
 641 CTGTTTTCCACTTGGAGTTATTTTAAAATTCAAAGTAAATCACTCTATTCTTATTTTGAAAACTCAGAGCCATTTTATAT
 721 AGAAACAAAACCCATAAGAGCACACAGTAACAAAGCAAACAGATACAAAAATGACTTTTTAGTTATGACAAATATTTTAG
 801 TTGGTTACTACTTAGGTCCTTTTGGCAAATGAAAATTTGTGATTAGAGTATAAATGGCAAAACTATCTTTTCCTGGCCTT
 881 TGAATCCACTAGTACTTAATGGATATAGCTGAAGCAGAGACTAAGTATAACATACAGGTTCTTCAGTAAAATATATCATT
 961 TTCATGTTATAGTTATGCCTGTGTGGCCTCTGTCAGAACTATTATCAGTAAAAGAGGTTAAGCCTATATATGAATGATGG
1041 ACCAAAACCTTGAGGTTGTACATTAACTGAAATAGTATTTTATAAAATCTTATGGTGCTGTGGAAAATATTTATTATTTC
1121 ACCTTTTCTGACACTTCACCATGGAGACTATTCAGGTAATACAATTTTAAGTCATTGCAGTTAATACTCTGGTTAATTGG
1201 TACTGTTAATCACCCAGGTCAGGAATTCTGATTTTAGGTTATCTCATTAATCATGGCTGATAAAGAAGCTAAGGGGATTC
1281 TCCAGATCTAATAGATTTCATTAGTCATTTGTGTCGAGTATTCCTCCCTAAAAACAAAAGCAGTATTTTCTTTCTCAATT
1361 AATTTTTAAGTTATTCATTAAAAAATATATAACATCTTAATTTTATTCTTTTAAAAACATACAGTGAAGCCTTGCTACAA
1441 GAGTCATAAGTGACTGGAATTTCTTGCATAATAGGTTCCTCCTTTTGAATAGATCAGATTCATCCCCAGGCTCTCAGCAG
1521 TGTCATGATGAAATGAGTGTGCTGACTTCAGGGGTGTGGTGGACACTGGTAGCTAGCCTTATCAGCTCCCTCCTTATTCC
1601 TACCTCTGTCAGCAGCATGCCTCGCCCCTTACCTAATTCTGCTGTGACTCTGACAGAGAGGAAGTGCCTTCTCACTTTGC
1681 AAAGGAATGCAGCATGTCACAAAGGAGGTGCTCCAATTTTTTGTGTCCTTACTTCCCTATGTTTGCCTAGTTACTGAGGC
1761 TAGGTCGAGTGTGAAGCAATAGGTGTAAGATGCTGAGAGCACATGGACAGCTACCAGGGAGATCTGTTGCTTGGTTACAG
1841 GGTGTATTCATGAGTGGTAGCTGCAGTTGTCGTGAGAGACATGCTTGGCATACAGAGCTGTCTAATGGGTGGGAGACATG
1921 TAATGGTAGATTTAGGGCTGGGAGCATGATTTTGGGTCTGCCCAAAGGAACATGGTGTCACTTTTGTTCTTTCTGACCCA
2001 CTAAATAAAAAGTAGTGTAACAGGGTTTCACTGGAATGTTTATTAGAAAGTTTACACTTTTTATATTTTTATGATTTTAA
2081 AAACAAACAATAATAGAAAAACAGATTTTAAGGAACTTCAGAGCAGTATATATTCTGTCTAAACTCACTGAATATTTTAA
2161 GTTGTAAATCAGGTGTCCACCAACCTTTATTTTTGCATTGCAGGAGATGTGACTGTAAAGTAGGGAGTTTTTTTTTTTGA
2241 GACAGAGTTTCACCCTTGTTGCCCAGGCTAGAGTGTAATGGTGCAATCTCCGCTCACTGCAACCTCTGCCTCCCAGGTTC
2321 AAGCGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCATGCACCACCACACCCGGCTAATTTTTTTATATT
2401 TTTAGTAGAGACAAGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGCCT
2481 CCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCAAATTATTTTTGTGGGTAGATTCATTCTCTTTACCTA
2561 ATAGTCATAATTTAGTCAGTGAAGGGACAACATCTGGGGTAAGAGCTATGGAGGAGGTGCTCAGCTTTGTGAGTTTTGTG
2641 CCAGGCATCTTTGCTGAAAATGGAGATGGCAGCAAGTGTGAATCTGGGGGAATATAAGGGAAGACAGAAAAGCCTTAAGA
2721 GTAGACGGAGGAAGAAGGGTACCAGAATAGTCCCTGTGGAGGCAGGCAGATCAGAGCTCAGGGTTTGAAAGTGGGCCTGA
2801 GTAAGGGTCCTGCTAGAGAAACTGCAGATGGAAGCTGAGCAGTTACCAACTGCTAATGTGCCAAGTATACCAAGCACAGC
2881 ATGTGTCCTGTAGAGGAGCATTATTTTAAACAATGTTCTACTATCATCTACCAAAATAATTGTGGTAAAAGTGTAGTATT
2961 TTATTTTTTCCTTTTATGTCAGCAATATTTTAAAATATTGATCTGTTTATCTTATATTTTTATGGATAAATGTAGTATTT
3041 GCCTCATGATTGTGAGCCACTGAGAGTGCACTGAACCTATTCACATGTCTTTAAGATGTTTTGCTGTGTTAAAATTTTAG
3121 GAGAGAAAAATACAAGTGAATAATTATTTAATAGGCATTTATTACTTTATTTTGGAGTTGAATTCTGTCATTTGAAAAAG
3201 TTCAGTAATGTAATAAATACAAAGTGATCTGCACTGTTAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auAACCGGAUUU---CUUUACUGUCu 5'
            || ||: |||   ||:|||:||| 
Target 5' tcTTTGCTGAAAATGGAGATGGCAGc 3'
 2648 - 2673 153.00 -13.60
2 
miRNA  3' auAAC-CGGAUUUC---UUUACUGUcu 5'
            ||| | :||:||   |||||:||  
Target 5' atTTGTGATTAGAGTATAAATGGCAaa 3'
 835 - 861 133.00 -8.90
3 
miRNA  3' auaacCGGAUUUCU--UUACUGUCu 5'
               ||||| | |  |||||::| 
Target 5' gttaaGCCTATATATGAATGATGGa 3'
 1017 - 1041 132.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31544551 49 COSMIC
COSN30145034 69 COSMIC
COSN31577899 81 COSMIC
COSN31525315 101 COSMIC
COSN31598037 102 COSMIC
COSN28740773 137 COSMIC
COSN1678649 215 COSMIC
COSN31580051 359 COSMIC
COSN31516085 474 COSMIC
COSN6275138 513 COSMIC
COSN31537036 540 COSMIC
COSN25826160 883 COSMIC
COSN31531072 1074 COSMIC
COSN26583725 1098 COSMIC
COSN26464979 1131 COSMIC
COSN31550396 1136 COSMIC
COSN22218274 1181 COSMIC
COSN30543156 1216 COSMIC
COSN22321911 1221 COSMIC
COSN23062733 1405 COSMIC
COSN5755143 1418 COSMIC
COSN505786 1522 COSMIC
COSN31606640 1916 COSMIC
COSN30166725 1968 COSMIC
COSN28723277 1977 COSMIC
COSN31588080 2020 COSMIC
COSN28128612 2065 COSMIC
COSN31562499 2195 COSMIC
COSN29863116 2226 COSMIC
COSN27586016 2239 COSMIC
COSN29456561 2383 COSMIC
COSN24896193 2445 COSMIC
COSN5212975 2524 COSMIC
COSN31595206 2638 COSMIC
COSN31590210 2670 COSMIC
COSN30541596 2777 COSMIC
COSN31566433 2917 COSMIC
COSN20092973 2976 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs774062011 2 dbSNP
rs149289204 14 dbSNP
rs1490168385 15 dbSNP
rs771888001 17 dbSNP
rs1282686041 24 dbSNP
rs912765724 31 dbSNP
rs1253871788 32 dbSNP
rs775309902 34 dbSNP
rs760193497 44 dbSNP
rs944451025 45 dbSNP
rs1049164769 46 dbSNP
rs1417514471 47 dbSNP
rs1171944997 51 dbSNP
rs758336860 55 dbSNP
rs144540406 60 dbSNP
rs1325979473 65 dbSNP
rs1404315564 66 dbSNP
rs139335966 69 dbSNP
rs1169335876 70 dbSNP
rs937147379 72 dbSNP
rs1475589118 75 dbSNP
rs1055662489 81 dbSNP
rs1369519865 82 dbSNP
rs1372317833 83 dbSNP
rs759601867 84 dbSNP
rs1234739063 86 dbSNP
rs1186519024 89 dbSNP
rs1469774136 92 dbSNP
rs1253625587 99 dbSNP
rs1214369991 101 dbSNP
rs1038807148 120 dbSNP
rs921582436 124 dbSNP
rs1216582055 131 dbSNP
rs189073711 134 dbSNP
rs3743045 137 dbSNP
rs1373821881 138 dbSNP
rs886357894 144 dbSNP
rs1019920930 147 dbSNP
rs557487901 148 dbSNP
rs575592148 149 dbSNP
rs1056301104 156 dbSNP
rs374649298 158 dbSNP
rs546140701 160 dbSNP
rs1000322136 164 dbSNP
rs1470155355 171 dbSNP
rs1455456456 190 dbSNP
rs1194594630 191 dbSNP
rs1032746735 192 dbSNP
rs1190573709 204 dbSNP
rs1012726046 208 dbSNP
rs953273401 208 dbSNP
rs1206819168 209 dbSNP
rs878983460 210 dbSNP
rs1252926579 218 dbSNP
rs1438597482 231 dbSNP
rs986259665 236 dbSNP
rs1274273251 260 dbSNP
rs1453076435 264 dbSNP
rs751059756 266 dbSNP
rs1350562133 284 dbSNP
rs866090103 288 dbSNP
rs966231882 291 dbSNP
rs1281606864 295 dbSNP
rs1159821327 298 dbSNP
rs972293099 303 dbSNP
rs1364791365 305 dbSNP
rs1408145438 315 dbSNP
rs1280795231 318 dbSNP
rs558173246 321 dbSNP
rs919228764 322 dbSNP
rs1156580403 327 dbSNP
rs1349465890 329 dbSNP
rs1305853632 330 dbSNP
rs930674970 334 dbSNP
rs1023736254 356 dbSNP
rs968431734 363 dbSNP
rs985225785 374 dbSNP
rs926711960 385 dbSNP
rs1351241029 386 dbSNP
rs1412703846 386 dbSNP
rs551096668 387 dbSNP
rs1472982112 391 dbSNP
rs7164027 396 dbSNP
rs540551799 401 dbSNP
rs752642031 403 dbSNP
rs987053192 410 dbSNP
rs1256954965 418 dbSNP
rs754496294 420 dbSNP
rs1448836877 428 dbSNP
rs1310941090 436 dbSNP
rs373916835 437 dbSNP
rs1280043738 444 dbSNP
rs1327895944 473 dbSNP
rs895652846 474 dbSNP
rs912713198 478 dbSNP
rs1374197050 495 dbSNP
rs1355791267 512 dbSNP
rs78205402 513 dbSNP
rs1445634243 522 dbSNP
rs1346860728 523 dbSNP
rs1159803605 533 dbSNP
rs780774834 541 dbSNP
rs1041646256 543 dbSNP
rs529440596 544 dbSNP
rs921720013 547 dbSNP
rs1476315324 550 dbSNP
rs1257195351 553 dbSNP
rs543942038 554 dbSNP
rs553043674 555 dbSNP
rs562202967 563 dbSNP
rs999846976 565 dbSNP
rs756740444 574 dbSNP
rs1272894315 583 dbSNP
rs1048765425 595 dbSNP
rs532791667 595 dbSNP
rs907572759 596 dbSNP
rs182168351 597 dbSNP
rs888856498 609 dbSNP
rs1363839166 611 dbSNP
rs1289334810 613 dbSNP
rs1007270548 616 dbSNP
rs1387920892 620 dbSNP
rs1364165123 622 dbSNP
rs115153189 623 dbSNP
rs1174909859 630 dbSNP
rs1215299069 656 dbSNP
rs527617718 658 dbSNP
rs1422397759 661 dbSNP
rs1461599660 666 dbSNP
rs1422105914 667 dbSNP
rs1189710354 670 dbSNP
rs972260614 674 dbSNP
rs1246799527 688 dbSNP
rs549278721 690 dbSNP
rs1214983975 698 dbSNP
rs567515086 701 dbSNP
rs574577364 706 dbSNP
rs186713274 713 dbSNP
rs1308967893 720 dbSNP
rs192441654 721 dbSNP
rs926651886 729 dbSNP
rs1227461122 735 dbSNP
rs1362935547 736 dbSNP
rs1305585126 737 dbSNP
rs959411803 745 dbSNP
rs1443134050 749 dbSNP
rs1277813601 751 dbSNP
rs1357629229 753 dbSNP
rs541617867 757 dbSNP
rs1292875866 761 dbSNP
rs1356557122 767 dbSNP
rs917056699 773 dbSNP
rs1449287766 781 dbSNP
rs1333238986 788 dbSNP
rs182002332 790 dbSNP
rs185160842 792 dbSNP
rs1041963743 800 dbSNP
rs1433221576 802 dbSNP
rs1266060192 805 dbSNP
rs1189039786 809 dbSNP
rs189585063 811 dbSNP
rs924549370 813 dbSNP
rs1481401143 817 dbSNP
rs1274984585 832 dbSNP
rs1204136882 836 dbSNP
rs1030959329 838 dbSNP
rs1282336671 851 dbSNP
rs757786122 852 dbSNP
rs1331698396 854 dbSNP
rs558100566 858 dbSNP
rs1385229726 866 dbSNP
rs75104984 874 dbSNP
rs1308918679 875 dbSNP
rs746214372 878 dbSNP
rs1429457328 879 dbSNP
rs1176003593 881 dbSNP
rs1467015924 893 dbSNP
rs1377611347 896 dbSNP
rs139791721 906 dbSNP
rs1420394545 910 dbSNP
rs1252056671 912 dbSNP
rs1181055154 923 dbSNP
rs1040113683 925 dbSNP
rs1481913882 926 dbSNP
rs540568924 926 dbSNP
rs1259376051 928 dbSNP
rs1186833561 936 dbSNP
rs1200885330 954 dbSNP
rs555629102 956 dbSNP
rs1254218796 965 dbSNP
rs964535506 967 dbSNP
rs1331348061 979 dbSNP
rs556782774 987 dbSNP
rs1289174100 989 dbSNP
rs1409442645 993 dbSNP
rs1415206784 995 dbSNP
rs993662791 999 dbSNP
rs1336543870 1005 dbSNP
rs1397040243 1008 dbSNP
rs1402077477 1030 dbSNP
rs1026941586 1038 dbSNP
rs1171385459 1044 dbSNP
rs1168214063 1045 dbSNP
rs952323985 1056 dbSNP
rs1157886588 1058 dbSNP
rs201368472 1075 dbSNP
rs7169746 1075 dbSNP
rs3825799 1076 dbSNP
rs1187962818 1078 dbSNP
rs1377391236 1079 dbSNP
rs1415467856 1098 dbSNP
rs1441683016 1100 dbSNP
rs1253937999 1101 dbSNP
rs959372327 1103 dbSNP
rs1206855741 1107 dbSNP
rs984577226 1108 dbSNP
rs1268864310 1109 dbSNP
rs1227927435 1115 dbSNP
rs768676788 1116 dbSNP
rs907516789 1117 dbSNP
rs940365377 1121 dbSNP
rs1353738866 1128 dbSNP
rs1245954618 1129 dbSNP
rs1340270623 1142 dbSNP
rs562465148 1144 dbSNP
rs2619685 1157 dbSNP
rs917985966 1159 dbSNP
rs1437924390 1163 dbSNP
rs917846403 1164 dbSNP
rs966823622 1165 dbSNP
rs1271099510 1181 dbSNP
rs1392405645 1186 dbSNP
rs1163505604 1191 dbSNP
rs977274670 1200 dbSNP
rs924447830 1204 dbSNP
rs935892668 1205 dbSNP
rs1054799343 1214 dbSNP
rs1449989285 1250 dbSNP
rs1485751922 1251 dbSNP
rs1052501379 1254 dbSNP
rs910191348 1256 dbSNP
rs1292228432 1257 dbSNP
rs1008201640 1261 dbSNP
rs1356022980 1269 dbSNP
rs1282779172 1280 dbSNP
rs1231164795 1285 dbSNP
rs1254965999 1286 dbSNP
rs1448329865 1300 dbSNP
rs1297576256 1301 dbSNP
rs943025743 1304 dbSNP
rs761592900 1312 dbSNP
rs544761680 1316 dbSNP
rs560122346 1329 dbSNP
rs1388204105 1333 dbSNP
rs779811934 1339 dbSNP
rs1047859637 1345 dbSNP
rs997539544 1357 dbSNP
rs1027150616 1359 dbSNP
rs1175511567 1363 dbSNP
rs1186616794 1363 dbSNP
rs61674204 1375 dbSNP
rs34848386 1380 dbSNP
rs1395594342 1381 dbSNP
rs151108704 1384 dbSNP
rs1312284798 1388 dbSNP
rs1400378182 1401 dbSNP
rs1033917108 1413 dbSNP
rs1384091045 1421 dbSNP
rs959632334 1441 dbSNP
rs1326253473 1447 dbSNP
rs1274502426 1458 dbSNP
rs1226845646 1468 dbSNP
rs1014702181 1469 dbSNP
rs1013586894 1482 dbSNP
rs961668789 1495 dbSNP
rs796751615 1496 dbSNP
rs186837714 1497 dbSNP
rs531540444 1502 dbSNP
rs1369749763 1503 dbSNP
rs765216634 1507 dbSNP
rs564104916 1508 dbSNP
rs1416091491 1514 dbSNP
rs1232967752 1519 dbSNP
rs1277507306 1522 dbSNP
rs978583986 1525 dbSNP
rs1477770748 1526 dbSNP
rs1031479851 1530 dbSNP
rs773081365 1531 dbSNP
rs990028798 1533 dbSNP
rs714784 1549 dbSNP
rs569271169 1551 dbSNP
rs1203520212 1555 dbSNP
rs1195198153 1559 dbSNP
rs77518339 1560 dbSNP
rs892552627 1562 dbSNP
rs1342284661 1580 dbSNP
rs1453686260 1581 dbSNP
rs758519675 1586 dbSNP
rs1376045784 1591 dbSNP
rs1455384802 1597 dbSNP
rs1305953177 1600 dbSNP
rs929033621 1603 dbSNP
rs1359653899 1614 dbSNP
rs1333453771 1621 dbSNP
rs540375976 1624 dbSNP
rs551579283 1625 dbSNP
rs1161573638 1637 dbSNP
rs887562839 1646 dbSNP
rs1455985926 1651 dbSNP
rs1175812915 1660 dbSNP
rs1041043326 1664 dbSNP
rs1484468868 1665 dbSNP
rs1328296454 1668 dbSNP
rs1238506434 1672 dbSNP
rs1210068757 1675 dbSNP
rs754688491 1679 dbSNP
rs1269490475 1681 dbSNP
rs1055337985 1687 dbSNP
rs1228544167 1693 dbSNP
rs899868460 1695 dbSNP
rs118060423 1703 dbSNP
rs1013853632 1705 dbSNP
rs1229770462 1709 dbSNP
rs1299777885 1709 dbSNP
rs1379667975 1711 dbSNP
rs1027675908 1717 dbSNP
rs888584883 1724 dbSNP
rs1004389517 1725 dbSNP
rs1239118492 1728 dbSNP
rs1457869573 1728 dbSNP
rs1259794469 1731 dbSNP
rs766086669 1738 dbSNP
rs533890372 1742 dbSNP
rs1326554527 1750 dbSNP
rs1157223659 1757 dbSNP
rs190095788 1767 dbSNP
rs1014649865 1768 dbSNP
rs1024939479 1781 dbSNP
rs1250487649 1782 dbSNP
rs752246719 1784 dbSNP
rs541514304 1788 dbSNP
rs902530078 1789 dbSNP
rs961785029 1791 dbSNP
rs1322040959 1792 dbSNP
rs999588057 1796 dbSNP
rs1467853532 1798 dbSNP
rs1032829573 1816 dbSNP
rs1024625384 1820 dbSNP
rs555641599 1825 dbSNP
rs573965595 1827 dbSNP
rs1298298759 1831 dbSNP
rs980685518 1835 dbSNP
rs1182546076 1843 dbSNP
rs538064132 1844 dbSNP
rs1459651850 1847 dbSNP
rs1350742944 1852 dbSNP
rs989940587 1858 dbSNP
rs1017427377 1859 dbSNP
rs925208842 1864 dbSNP
rs1392518920 1869 dbSNP
rs964567641 1873 dbSNP
rs556750428 1882 dbSNP
rs1292135892 1889 dbSNP
rs1259076921 1893 dbSNP
rs35520865 1907 dbSNP
rs28456256 1911 dbSNP
rs1455796726 1919 dbSNP
rs922918845 1927 dbSNP
rs1264530751 1939 dbSNP
rs1219944925 1950 dbSNP
rs1344065338 1971 dbSNP
rs1275216580 1973 dbSNP
rs928950240 1976 dbSNP
rs1306930703 1990 dbSNP
rs987941186 1992 dbSNP
rs1388638413 1995 dbSNP
rs1461243930 1996 dbSNP
rs1368546766 2000 dbSNP
rs545135843 2015 dbSNP
rs755633349 2016 dbSNP
rs779448874 2018 dbSNP
rs746412443 2024 dbSNP
rs1169723646 2031 dbSNP
rs1429661818 2035 dbSNP
rs1371922389 2037 dbSNP
rs1177563637 2047 dbSNP
rs921261303 2049 dbSNP
rs1391464698 2051 dbSNP
rs1196871727 2053 dbSNP
rs758719916 2056 dbSNP
rs949591315 2061 dbSNP
rs542361782 2081 dbSNP
rs932656059 2081 dbSNP
rs1046695085 2086 dbSNP
rs751121215 2089 dbSNP
rs1235454025 2097 dbSNP
rs76952412 2104 dbSNP
rs999916482 2127 dbSNP
rs1221931131 2129 dbSNP
rs1219094481 2133 dbSNP
rs183829316 2162 dbSNP
rs141136861 2172 dbSNP
rs188327490 2181 dbSNP
rs1006939882 2184 dbSNP
rs1017355445 2185 dbSNP
rs1002279454 2191 dbSNP
rs55912100 2195 dbSNP
rs1471632503 2202 dbSNP
rs1190415186 2217 dbSNP
rs1418828526 2218 dbSNP
rs1473360041 2219 dbSNP
rs1412337152 2221 dbSNP
rs776788188 2226 dbSNP
rs1435890596 2228 dbSNP
rs957940365 2228 dbSNP
rs1200968817 2231 dbSNP
rs1483588082 2240 dbSNP
rs1475091049 2242 dbSNP
rs988057277 2244 dbSNP
rs1331450101 2262 dbSNP
rs1289270690 2263 dbSNP
rs1375312418 2266 dbSNP
rs1030643927 2267 dbSNP
rs1334381883 2276 dbSNP
rs561191278 2279 dbSNP
rs746376991 2284 dbSNP
rs1397134965 2285 dbSNP
rs950700429 2292 dbSNP
rs531605287 2293 dbSNP
rs1158006214 2296 dbSNP
rs908885186 2311 dbSNP
rs1313176681 2315 dbSNP
rs1188072442 2316 dbSNP
rs976832746 2318 dbSNP
rs942996228 2325 dbSNP
rs990585526 2326 dbSNP
rs1466325036 2332 dbSNP
rs916720779 2341 dbSNP
rs1268955311 2347 dbSNP
rs932636324 2351 dbSNP
rs1267591514 2353 dbSNP
rs1307836911 2360 dbSNP
rs1246070825 2367 dbSNP
rs748247476 2370 dbSNP
rs1226654485 2373 dbSNP
rs1272381615 2374 dbSNP
rs769813464 2383 dbSNP
rs1046626149 2384 dbSNP
rs1258489682 2385 dbSNP
rs1317129378 2389 dbSNP
rs1398585403 2396 dbSNP
rs1392526202 2397 dbSNP
rs1483023052 2398 dbSNP
rs1163593938 2406 dbSNP
rs1423827875 2407 dbSNP
rs1383247025 2408 dbSNP
rs924185548 2417 dbSNP
rs1451331636 2426 dbSNP
rs1248734778 2429 dbSNP
rs940238821 2433 dbSNP
rs550087701 2436 dbSNP
rs895960254 2444 dbSNP
rs1054165061 2445 dbSNP
rs893811657 2448 dbSNP
rs1170447310 2452 dbSNP
rs1269077148 2458 dbSNP
rs1014856206 2461 dbSNP
rs1332444630 2465 dbSNP
rs1323836991 2466 dbSNP
rs1404063802 2467 dbSNP
rs1006907321 2471 dbSNP
rs1039778604 2472 dbSNP
rs1173642240 2477 dbSNP
rs1430316971 2480 dbSNP
rs901287204 2485 dbSNP
rs1418797888 2486 dbSNP
rs1046108308 2488 dbSNP
rs1001993902 2491 dbSNP
rs1445422533 2492 dbSNP
rs1290236089 2494 dbSNP
rs1362477198 2503 dbSNP
rs565131678 2504 dbSNP
rs530326151 2505 dbSNP
rs60191974 2505 dbSNP
rs1272987143 2516 dbSNP
rs543259648 2517 dbSNP
rs1349879368 2520 dbSNP
rs773171719 2521 dbSNP
rs893494857 2527 dbSNP
rs1343312861 2530 dbSNP
rs1309617352 2536 dbSNP
rs1009423198 2539 dbSNP
rs1353833873 2544 dbSNP
rs1281063305 2549 dbSNP
rs1311660688 2552 dbSNP
rs1427374042 2553 dbSNP
rs1177317103 2554 dbSNP
rs1020839543 2562 dbSNP
rs1427516846 2568 dbSNP
rs1184762731 2581 dbSNP
rs1470731640 2597 dbSNP
rs551860889 2605 dbSNP
rs1232772570 2609 dbSNP
rs1203038933 2613 dbSNP
rs1208337338 2617 dbSNP
rs1278693837 2619 dbSNP
rs1202558569 2642 dbSNP
rs1320931301 2648 dbSNP
rs1289884074 2665 dbSNP
rs1228726472 2668 dbSNP
rs1372352773 2670 dbSNP
rs950657058 2671 dbSNP
rs566804551 2674 dbSNP
rs1277643321 2677 dbSNP
rs1450111429 2693 dbSNP
rs1359739757 2711 dbSNP
rs965216470 2713 dbSNP
rs1469401745 2723 dbSNP
rs1486433100 2725 dbSNP
rs145800630 2727 dbSNP
rs193283009 2728 dbSNP
rs1016320770 2733 dbSNP
rs1407726826 2734 dbSNP
rs763005344 2739 dbSNP
rs141799414 2740 dbSNP
rs954270335 2744 dbSNP
rs1193742182 2753 dbSNP
rs984230756 2754 dbSNP
rs909872091 2755 dbSNP
rs1269582815 2760 dbSNP
rs770328272 2763 dbSNP
rs1412257049 2770 dbSNP
rs1316028860 2780 dbSNP
rs1281882740 2784 dbSNP
rs1160908015 2792 dbSNP
rs1345355068 2804 dbSNP
rs1452790460 2806 dbSNP
rs1379781392 2810 dbSNP
rs1314325308 2813 dbSNP
rs990513424 2816 dbSNP
rs940016314 2820 dbSNP
rs1322736864 2833 dbSNP
rs916316237 2834 dbSNP
rs1344896486 2837 dbSNP
rs750061545 2840 dbSNP
rs917509182 2843 dbSNP
rs1441605527 2844 dbSNP
rs1302554464 2845 dbSNP
rs1367081846 2848 dbSNP
rs970505546 2850 dbSNP
rs147052398 2858 dbSNP
rs924141055 2859 dbSNP
rs138400924 2862 dbSNP
rs906070499 2868 dbSNP
rs1186669866 2875 dbSNP
rs1485323756 2879 dbSNP
rs1240053939 2882 dbSNP
rs766217420 2888 dbSNP
rs1223438340 2910 dbSNP
rs578154448 2911 dbSNP
rs1290867912 2913 dbSNP
rs1243696595 2918 dbSNP
rs1344299206 2923 dbSNP
rs538817650 2927 dbSNP
rs1317674567 2947 dbSNP
rs1053494211 2954 dbSNP
rs1361500827 2956 dbSNP
rs1054063752 2959 dbSNP
rs1266573371 2962 dbSNP
rs915215227 2964 dbSNP
rs1366586390 2983 dbSNP
rs1470081116 2992 dbSNP
rs185452908 2993 dbSNP
rs1246622940 2998 dbSNP
rs1423287011 2999 dbSNP
rs1392615608 3002 dbSNP
rs1476762580 3009 dbSNP
rs867736537 3015 dbSNP
rs1170508590 3024 dbSNP
rs1178360744 3025 dbSNP
rs901256246 3027 dbSNP
rs142328842 3032 dbSNP
rs1051993727 3038 dbSNP
rs1490436940 3053 dbSNP
rs1267897185 3069 dbSNP
rs886292076 3077 dbSNP
rs759470661 3087 dbSNP
rs1005177991 3106 dbSNP
rs1483976002 3115 dbSNP
rs1251864538 3120 dbSNP
rs186819824 3124 dbSNP
rs191234107 3131 dbSNP
rs1225569012 3140 dbSNP
rs1346463691 3140 dbSNP
rs1011918225 3141 dbSNP
rs1302895207 3143 dbSNP
rs771007696 3147 dbSNP
rs1403542404 3155 dbSNP
rs1017049723 3162 dbSNP
rs1225592397 3175 dbSNP
rs1023340808 3194 dbSNP
rs970432008 3195 dbSNP
rs1352278861 3196 dbSNP
rs1396467646 3203 dbSNP
rs1480554702 3209 dbSNP
rs1461768654 3218 dbSNP
rs752337996 3229 dbSNP
rs1196984611 3231 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaaccGGAUU---UCUUUACUGucu 5'
                |||||    |  :||||   
Target 5' cccuuaCCUAAUUCUGCUGUGACucu 3'
 		2 - 27
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000261842.5 | 3UTR | CCCCUUACCUAAUUCUGCUGUGACUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
96 hsa-miR-215-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT058509 TEAD1 TEA domain transcription factor 1 2 2
MIRT445625 TMEM50A transmembrane protein 50A 2 2
MIRT449286 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT456702 LDB1 LIM domain binding 1 2 2
MIRT467723 SLC38A1 solute carrier family 38 member 1 2 2
MIRT474253 LATS2 large tumor suppressor kinase 2 2 2
MIRT481811 AP4E1 adaptor related protein complex 4 epsilon 1 subunit 2 2
MIRT491969 USP37 ubiquitin specific peptidase 37 2 2
MIRT513203 RFT1 RFT1 homolog 2 2
MIRT532737 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT535706 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT536138 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536463 KLF12 Kruppel like factor 12 2 4
MIRT552615 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT554011 SPIRE1 spire type actin nucleation factor 1 2 2
MIRT563259 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT571054 POLQ DNA polymerase theta 2 4
MIRT573556 TMEM120B transmembrane protein 120B 2 2
MIRT573772 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT575328 Fbxo6 F-box protein 6 2 2
MIRT575497 Sept3 septin 3 2 5
MIRT607051 IDS iduronate 2-sulfatase 2 2
MIRT607070 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607497 HEBP2 heme binding protein 2 2 2
MIRT607799 RHBDL2 rhomboid like 2 2 2
MIRT610832 COL9A1 collagen type IX alpha 1 chain 2 2
MIRT616853 DSG2 desmoglein 2 2 2
MIRT617154 C18orf42 A-kinase anchor inhibitor 1 2 2
MIRT620823 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT625698 OPTN optineurin 2 2
MIRT628082 KAT7 lysine acetyltransferase 7 2 2
MIRT633540 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634343 SGOL1 shugoshin 1 2 2
MIRT634605 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT636759 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637044 SEPT3 septin 3 2 7
MIRT637213 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT639634 ZSCAN23 zinc finger and SCAN domain containing 23 2 2
MIRT640818 GPR107 G protein-coupled receptor 107 2 2
MIRT641033 PITPNB phosphatidylinositol transfer protein beta 2 2
MIRT641545 MOCOS molybdenum cofactor sulfurase 2 2
MIRT642091 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT645528 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT647017 ADCY2 adenylate cyclase 2 2 2
MIRT648044 FADS6 fatty acid desaturase 6 2 2
MIRT648514 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648869 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT656722 LMLN leishmanolysin like peptidase 2 2
MIRT658260 FAXC failed axon connections homolog 2 2
MIRT659063 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT659364 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT660318 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT663345 ZNF74 zinc finger protein 74 2 2
MIRT663526 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663975 ZNF786 zinc finger protein 786 2 2
MIRT664354 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664473 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664975 TDRD1 tudor domain containing 1 2 2
MIRT665488 VPS53 VPS53, GARP complex subunit 2 2
MIRT667758 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT669552 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT670183 CCDC142 coiled-coil domain containing 142 2 2
MIRT671342 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671873 ZNF429 zinc finger protein 429 2 2
MIRT672018 PXMP4 peroxisomal membrane protein 4 2 2
MIRT672068 KIAA0930 KIAA0930 2 2
MIRT672551 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT672849 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT672988 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT673088 AK1 adenylate kinase 1 2 2
MIRT673578 KDELC2 KDEL motif containing 2 2 2
MIRT674582 SLC35B4 solute carrier family 35 member B4 2 2
MIRT674999 STRN3 striatin 3 2 2
MIRT675596 ZNF106 zinc finger protein 106 2 2
MIRT675778 YIPF4 Yip1 domain family member 4 2 2
MIRT676029 C9orf69 transmembrane protein 250 2 2
MIRT679015 MTMR10 myotubularin related protein 10 2 2
MIRT679169 PSMB2 proteasome subunit beta 2 2 2
MIRT687413 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT688038 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT691644 SLC43A3 solute carrier family 43 member 3 2 2
MIRT695630 SLC26A2 solute carrier family 26 member 2 2 2
MIRT697562 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT699153 SMC1A structural maintenance of chromosomes 1A 2 2
MIRT699683 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT702177 LYRM4 LYR motif containing 4 2 2
MIRT706217 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT711243 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT712343 NLN neurolysin 2 2
MIRT716574 HOPX HOP homeobox 2 2
MIRT717443 TENM1 teneurin transmembrane protein 1 2 2
MIRT717759 KCNRG potassium channel regulator 2 2
MIRT717945 TUBD1 tubulin delta 1 2 2
MIRT718343 PURA purine rich element binding protein A 2 2
MIRT718773 ABHD15 abhydrolase domain containing 15 2 2
MIRT737073 FOXM1 forkhead box M1 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-215 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-215 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-215 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-215 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-215 Furan NULL 8029 Quantitative real-time PCR liver 22079235 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-215 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-215 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-215 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-215-3p Fluorouracil 3385 NSC19893 approved sensitive Low Colon Cancer cell line (HCT-116)
hsa-miR-215-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-215-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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