pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AMOTL2   
Synonyms LCCP
Description angiomotin like 2
Transcript NM_016201   
Expression
Putative miRNA Targets on AMOTL2
3'UTR of AMOTL2
(miRNA target sites are highlighted)
>AMOTL2|NM_016201|3'UTR
   1 AGGAGGTGGTGCTTCAGGACTCTGAGCCATTCTCTCCCCTCCTCTGCCCTGTGCCACTCTCAGCCATTTCAGCAGCCCCG
  81 TCAACCGCTGCTCCGTCCCTTTCCCCAGCCAGACACTCATTCCCATTGACCATCTGGTCCCAGGAGCTCAGGAGGAGGAC
 161 CCCAGGGGAGAGGAGAGCTGTGAGAGCACCGGCACCCCCAGAAGACTCTGCTTCTTAGCCCACATTCCTCCGGGCCTTAT
 241 GGAGAATGAGGATTCAGCCTTGACTTCTTGCCCAAGGCCTGCTACTGGGGTAGCAACTGACAGCTCAGAAAGGAGCTGAG
 321 CTCCCTCTGCCCTGCCAGTTGTCAGTCAGGCAGGGAGGGAGTGGCTGTGTTGGTTTGGGGAACTAATTTCCACGGACGGC
 401 TGCCCGTGGACACCAGGTGGACTGGTTCACTAATCAAGTCAGCCATATTGTTCTCTGGCTAAGTTTGGTTCCAGCCAACG
 481 TCATCTGCTCTTCAGTTCCTCACTGCCTTCTTGGGATACTAAGACTTGAATTTTTTGGGGACTATTAAGGGTGTTAGTCT
 561 TGGAGAAGACACAGCCTCACCTTCTCACTTGCTGTGGGTGAGGGGCCATTTAAGTGGACTGGGAGACAGTGCGCAGTTTG
 641 TATATAATTCCCTTTCTTGTGGAACAGAAGACTGAGGCCTGCAGGTTCCGATGTGTCTCCATGGGCTGTGCTCCCCTCTT
 721 CCTACTGTCAGTTTCTGAAACTTCTGACTGGCCTCCCAGTTATGCCTCCTCCTCAAGTTCCTGGCCCGTGGATGTTAAAG
 801 CTGCTCGATTCCCAGGATCTCGGCTGCCTTTTCCTCTATCTTGAGCCCTATAAATGCCCACGGGACCCCCACCACCAGCC
 881 TCTTGAAGTGGCTCCACAGCTCCTGTCCCTGGAACATCCTGTCAGTTTGGTCATAAACCCTGAGCCAGATGAAATGAGCC
 961 ACCGTGAACAGACATCTGCCATGCCCCCAGGTGGGCTTCGGTGGCCCTACCCGGTACCAGTTCTTTCTGAGAAACTGGAG
1041 ATGTCTTGTTAGCATAAGTGTCTTCATTCCCACCTGGAGGGTTTGGGAGAGGAGCAAAGCAGTTGAAAACTAGTTAATGA
1121 GCTACAAGAGTCAAATAGTCCTCTGAATGGAGCCCCCATCACAAAACAGTGCCCAGGAGGCTGGCTCCTCAAGCTACCCA
1201 TGCCCAGCGCCCTAAAGCAGCACCAGATGCTTTGGAATTGGGGTGAAACACCCACATGGCAGCCTGCTAGCAGCAGTGAC
1281 TTTGACTTCTGGTCTTAAAGAGTCCCTCACTTCAGCCCCAGGAGCTATTGGTGGGTTTTAGCAGTTTTGTCTTTACCGTT
1361 TTTAGTTCTCCTTGATTCTTTGTTTTCTTCCTTTATCGTTTTTAGGTTTGGTATGTGTTGTTTTATTTCCATGGTTCCTC
1441 AAGTTTCCTTTTTAAACATTTGCATTTGCTGGACAATTGCAATTTTTTTTAAAAAATTCCCCTACCCCTGTTTAAAGCTG
1521 AAAAATACATTTGGTTCATGTGCATTGTTTACAAAGCAAAAAGAAAAAAGAGGAAAAAAAGGCAAAAAATATTGTGAAAG
1601 AAAAAAAACAACTTAATATATTTTGGATTAATATTTGGTATTTCTTTTAAAGTATTTTTTGTGCTGTGAACATTTTCTGC
1681 CAAAGACCATGATGTGTGTCTGTATGTTTAAGTTATCGTAAATATTTAAAATGTAAACATGGCTGTTTTGTTATGCCACC
1761 CTGTACCAGGATTGCTGCCGCATTCCACTGGGTATAACAGTATTTTAATTAAAAAAAAATAATTAAAAGTGATGTCTTTG
1841 CACAGGTGAGACTTTGCACTGAGGGAAGGGAAAGGGTGAGGATTTTGGGGGGCCACCCAAGTCATAGTCCAATCTCTTCA
1921 AGGACCCAAGATAGAATTTAGGAATTTTGTGAAGCTGCATTAAGGATAGAGTTGGAATGAGGATGTGGCTGGCATTTTTC
2001 CCCTTTCATAGATAACATTTCTTGAAGGCTGGGAGGGGAAGGAGGGCCTGGCAGATGGCAGCCTCCCGAGGTAGGGCTGT
2081 GTTCTAATCAGCTTTGTTCGGCCACACGCTGTGGTTATCCACAGTGGGAGTGGGTGTCCAAAGATGGCTTTATCCTTCCC
2161 CCACTCCTTTTCCCACTCCCACCTAGCACATAAAGTTTTGTCCGAAACCATCCAGAAGGCCAGGCACCATGCAGAGGACA
2241 TTCAAGAATGTGCATGTTCTTAGCCACCGCCTCCCTCCTTTGCTGTGACATCACCACTCTTTCCTGATGCTCAGGAAAGC
2321 ATATTGCTCCAATTCAAAATTAAAGAAAGCCATTCTCAGT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacAGGUGAAGAAGGACGGGAc 5'
             ||| || ||  ||||||| 
Target 5' ctcTCCCCTCCT--CTGCCCTg 3'
32 - 51 159.00 -19.10
2
miRNA  3' aacAGGUGAAGAAG-GACGGGAc 5'
             |:|| ||| || |||||:| 
Target 5' ctcTTCAGTTCCTCACTGCCTTc 3'
488 - 510 151.00 -15.60
3
miRNA  3' aacaggUGAAGAAGGACGGGAc 5'
                :|| | | ||||||| 
Target 5' agctgaGCTCCCT-CTGCCCTg 3'
314 - 334 147.00 -17.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30509182 9 COSMIC
COSN30495871 31 COSMIC
COSN31581775 59 COSMIC
COSN30523614 70 COSMIC
COSN26965924 80 COSMIC
COSN26841761 86 COSMIC
COSN14498621 87 COSMIC
COSN30451841 98 COSMIC
COSN30509808 123 COSMIC
COSN30510946 126 COSMIC
COSN22168038 134 COSMIC
COSN30176540 161 COSMIC
COSN1267983 171 COSMIC
COSN19238158 368 COSMIC
COSN31577434 522 COSMIC
COSN26639902 542 COSMIC
COSN1267982 553 COSMIC
COSN26565964 606 COSMIC
COSN24034821 746 COSMIC
COSN31596532 785 COSMIC
COSN28744258 932 COSMIC
COSN32056356 1208 COSMIC
COSN8488302 1217 COSMIC
COSN31542948 1368 COSMIC
COSN31595495 1370 COSMIC
COSN1914939 1455 COSMIC
COSN31611227 1482 COSMIC
COSN14034321 1490 COSMIC
COSN14034319 1491 COSMIC
COSN4811286 1498 COSMIC
COSN31593226 1737 COSMIC
COSN31556591 1810 COSMIC
COSN23106719 1811 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749069936 2 dbSNP
rs770344425 5 dbSNP
rs1281112942 10 dbSNP
rs1221928950 11 dbSNP
rs1437868756 12 dbSNP
rs755736379 14 dbSNP
rs752254423 15 dbSNP
rs746432080 18 dbSNP
rs754385200 19 dbSNP
rs750942114 21 dbSNP
rs757147755 21 dbSNP
rs1287018036 24 dbSNP
rs753843754 25 dbSNP
rs1174026389 26 dbSNP
rs191988589 31 dbSNP
rs1460417088 34 dbSNP
rs781668635 37 dbSNP
rs948250748 38 dbSNP
rs546488524 39 dbSNP
rs142696435 41 dbSNP
rs896993017 42 dbSNP
rs763584864 45 dbSNP
rs760230621 47 dbSNP
rs1306063722 57 dbSNP
rs1238222389 70 dbSNP
rs931355637 71 dbSNP
rs1004982873 74 dbSNP
rs895877119 78 dbSNP
rs1057154295 79 dbSNP
rs937328346 80 dbSNP
rs1191355253 85 dbSNP
rs1381186319 86 dbSNP
rs927604720 87 dbSNP
rs570666973 88 dbSNP
rs918589716 92 dbSNP
rs1467282352 94 dbSNP
rs757748021 95 dbSNP
rs550519624 100 dbSNP
rs947603393 112 dbSNP
rs138691047 128 dbSNP
rs913410936 129 dbSNP
rs965741625 130 dbSNP
rs1360342583 140 dbSNP
rs912510317 144 dbSNP
rs1381991093 149 dbSNP
rs561804085 149 dbSNP
rs557272594 158 dbSNP
rs1342935995 160 dbSNP
rs751786467 161 dbSNP
rs1333433971 163 dbSNP
rs1221890550 165 dbSNP
rs1390142932 171 dbSNP
rs187906853 172 dbSNP
rs1484798169 187 dbSNP
rs985177366 190 dbSNP
rs183281144 191 dbSNP
rs1478752273 196 dbSNP
rs1425052963 198 dbSNP
rs1417291548 200 dbSNP
rs1255977251 210 dbSNP
rs778175841 214 dbSNP
rs111614249 215 dbSNP
rs1011339886 226 dbSNP
rs1289805017 228 dbSNP
rs56874024 231 dbSNP
rs114947994 232 dbSNP
rs1013404928 233 dbSNP
rs1354292086 234 dbSNP
rs1350216039 240 dbSNP
rs1002565060 246 dbSNP
rs575111594 249 dbSNP
rs1489218542 265 dbSNP
rs895928288 278 dbSNP
rs1036177524 279 dbSNP
rs1286590893 280 dbSNP
rs1001584932 284 dbSNP
rs1489127798 287 dbSNP
rs755399517 293 dbSNP
rs547850825 301 dbSNP
rs1012448613 316 dbSNP
rs895319266 321 dbSNP
rs192473335 329 dbSNP
rs1406135758 338 dbSNP
rs1048508114 346 dbSNP
rs1414065527 350 dbSNP
rs1418735129 355 dbSNP
rs1159407709 362 dbSNP
rs1382585897 363 dbSNP
rs931417862 365 dbSNP
rs3732853 367 dbSNP
rs1156653984 368 dbSNP
rs1299800319 369 dbSNP
rs147296812 374 dbSNP
rs1448203639 382 dbSNP
rs1304063874 385 dbSNP
rs3732852 393 dbSNP
rs1222851320 394 dbSNP
rs747507248 398 dbSNP
rs1293756080 401 dbSNP
rs541969387 405 dbSNP
rs76919889 406 dbSNP
rs1442924002 407 dbSNP
rs1212082312 409 dbSNP
rs1231254827 410 dbSNP
rs912353822 413 dbSNP
rs953909575 414 dbSNP
rs985616674 415 dbSNP
rs1382380328 417 dbSNP
rs1453007275 421 dbSNP
rs932384173 428 dbSNP
rs1478433351 434 dbSNP
rs115085348 439 dbSNP
rs1267321111 442 dbSNP
rs989957651 453 dbSNP
rs1446795897 461 dbSNP
rs1445380029 463 dbSNP
rs1331670347 468 dbSNP
rs956047707 479 dbSNP
rs973708907 480 dbSNP
rs7645136 487 dbSNP
rs142305798 495 dbSNP
rs552343234 501 dbSNP
rs1015504551 517 dbSNP
rs74910485 536 dbSNP
rs1272591726 537 dbSNP
rs960822430 539 dbSNP
rs1240331421 541 dbSNP
rs1219397852 544 dbSNP
rs537039496 557 dbSNP
rs182846502 565 dbSNP
rs971123977 578 dbSNP
rs1247657003 591 dbSNP
rs375505675 603 dbSNP
rs761167851 605 dbSNP
rs138219569 607 dbSNP
rs773895703 609 dbSNP
rs1170761964 614 dbSNP
rs528152583 619 dbSNP
rs532787018 621 dbSNP
rs746358281 622 dbSNP
rs995721105 624 dbSNP
rs897309362 628 dbSNP
rs1037159427 629 dbSNP
rs781771238 632 dbSNP
rs565795651 633 dbSNP
rs1021599819 635 dbSNP
rs1324622305 637 dbSNP
rs1361178186 644 dbSNP
rs1219386253 647 dbSNP
rs547187552 647 dbSNP
rs1049728964 656 dbSNP
rs1053296676 659 dbSNP
rs1290836033 662 dbSNP
rs1453729089 663 dbSNP
rs1191487544 677 dbSNP
rs1242108158 678 dbSNP
rs1478443092 681 dbSNP
rs932573320 689 dbSNP
rs914514801 692 dbSNP
rs1049892396 699 dbSNP
rs932409918 701 dbSNP
rs1131932 713 dbSNP
rs1390962639 723 dbSNP
rs1406942681 724 dbSNP
rs147229516 732 dbSNP
rs1359592879 742 dbSNP
rs1400535974 748 dbSNP
rs747382688 753 dbSNP
rs934545696 758 dbSNP
rs973761097 763 dbSNP
rs370658188 765 dbSNP
rs1244121581 768 dbSNP
rs1285078502 771 dbSNP
rs1452802883 774 dbSNP
rs1252668911 775 dbSNP
rs981214554 779 dbSNP
rs971520047 785 dbSNP
rs1203559656 787 dbSNP
rs1284013633 788 dbSNP
rs777799915 796 dbSNP
rs1488799039 800 dbSNP
rs564785991 801 dbSNP
rs1022598470 803 dbSNP
rs6801027 806 dbSNP
rs960624142 807 dbSNP
rs951703784 809 dbSNP
rs1186218916 811 dbSNP
rs1368741336 812 dbSNP
rs1193982979 821 dbSNP
rs1027230154 822 dbSNP
rs1420030116 837 dbSNP
rs980607191 845 dbSNP
rs970572870 847 dbSNP
rs1021652045 860 dbSNP
rs996160584 861 dbSNP
rs140307647 862 dbSNP
rs897325042 865 dbSNP
rs1308739114 870 dbSNP
rs1354933688 875 dbSNP
rs1242728383 879 dbSNP
rs1278893844 880 dbSNP
rs1483201425 885 dbSNP
rs78506634 892 dbSNP
rs1256244388 895 dbSNP
rs1008325496 903 dbSNP
rs1443597936 905 dbSNP
rs1031598176 909 dbSNP
rs541832820 913 dbSNP
rs1440159152 916 dbSNP
rs572971240 918 dbSNP
rs1465492311 921 dbSNP
rs932666576 938 dbSNP
rs1404471352 944 dbSNP
rs1389722749 956 dbSNP
rs1330981516 958 dbSNP
rs1050369778 959 dbSNP
rs1449537373 961 dbSNP
rs772424123 963 dbSNP
rs898280530 964 dbSNP
rs1409862394 965 dbSNP
rs1258231724 971 dbSNP
rs1403622273 974 dbSNP
rs1038125776 983 dbSNP
rs1433260202 984 dbSNP
rs939714767 987 dbSNP
rs779017668 988 dbSNP
rs908216470 989 dbSNP
rs1056115781 999 dbSNP
rs553076155 1000 dbSNP
rs926543091 1004 dbSNP
rs1460587992 1006 dbSNP
rs893134159 1009 dbSNP
rs967899857 1010 dbSNP
rs1467382920 1011 dbSNP
rs1367370101 1012 dbSNP
rs753725232 1013 dbSNP
rs1054417999 1018 dbSNP
rs934531484 1023 dbSNP
rs4974498 1025 dbSNP
rs151272989 1027 dbSNP
rs1317953516 1029 dbSNP
rs530009591 1038 dbSNP
rs990201420 1040 dbSNP
rs561357014 1041 dbSNP
rs1476807211 1042 dbSNP
rs1192766166 1043 dbSNP
rs1424458691 1044 dbSNP
rs1031650645 1045 dbSNP
rs1231216875 1047 dbSNP
rs1349482671 1052 dbSNP
rs1458791099 1055 dbSNP
rs1181266096 1057 dbSNP
rs1383175852 1064 dbSNP
rs1399969422 1082 dbSNP
rs1279335293 1087 dbSNP
rs1340650843 1092 dbSNP
rs751764443 1095 dbSNP
rs1008208997 1101 dbSNP
rs1279264120 1107 dbSNP
rs113475432 1110 dbSNP
rs1320727547 1110 dbSNP
rs1345511473 1123 dbSNP
rs1279109056 1124 dbSNP
rs767271237 1130 dbSNP
rs915691871 1133 dbSNP
rs536899690 1136 dbSNP
rs1489333279 1154 dbSNP
rs116551572 1155 dbSNP
rs1413095169 1156 dbSNP
rs1277258936 1169 dbSNP
rs1341552728 1170 dbSNP
rs1028565789 1171 dbSNP
rs991193008 1187 dbSNP
rs1362449353 1188 dbSNP
rs997461001 1197 dbSNP
rs951755867 1204 dbSNP
rs898669514 1205 dbSNP
rs761519020 1208 dbSNP
rs866323564 1209 dbSNP
rs1315357401 1214 dbSNP
rs879195208 1216 dbSNP
rs9450 1221 dbSNP
rs1396279394 1225 dbSNP
rs533218260 1226 dbSNP
rs1375244274 1227 dbSNP
rs1159670766 1230 dbSNP
rs534623121 1237 dbSNP
rs565758921 1249 dbSNP
rs1286732162 1250 dbSNP
rs1355788350 1251 dbSNP
rs1406135694 1253 dbSNP
rs763613060 1255 dbSNP
rs1483593885 1256 dbSNP
rs1183867957 1259 dbSNP
rs1158010262 1263 dbSNP
rs1473171331 1264 dbSNP
rs762588112 1279 dbSNP
rs1056557481 1293 dbSNP
rs1159618571 1300 dbSNP
rs1382491901 1304 dbSNP
rs191350252 1306 dbSNP
rs926568278 1307 dbSNP
rs1484675980 1308 dbSNP
rs142371003 1309 dbSNP
rs996930980 1321 dbSNP
rs1304265452 1325 dbSNP
rs202213680 1327 dbSNP
rs1445845528 1331 dbSNP
rs1309723075 1332 dbSNP
rs1378788860 1335 dbSNP
rs771579443 1342 dbSNP
rs1281713029 1348 dbSNP
rs117257273 1352 dbSNP
rs1356477321 1355 dbSNP
rs186350896 1357 dbSNP
rs751488446 1358 dbSNP
rs141200519 1367 dbSNP
rs903073925 1371 dbSNP
rs1045639311 1378 dbSNP
rs1299172679 1379 dbSNP
rs955397718 1381 dbSNP
rs1433339688 1382 dbSNP
rs1477216334 1389 dbSNP
rs369851176 1398 dbSNP
rs915744229 1399 dbSNP
rs975700506 1401 dbSNP
rs1055475485 1409 dbSNP
rs962929529 1411 dbSNP
rs1177947945 1413 dbSNP
rs1017135165 1416 dbSNP
rs1405973795 1425 dbSNP
rs747576929 1431 dbSNP
rs920274556 1434 dbSNP
rs972117501 1438 dbSNP
rs1433990242 1447 dbSNP
rs961718273 1450 dbSNP
rs1420080992 1454 dbSNP
rs908815974 1463 dbSNP
rs773623980 1477 dbSNP
rs78019276 1482 dbSNP
rs182902096 1490 dbSNP
rs1034769195 1491 dbSNP
rs555670940 1491 dbSNP
rs576974941 1502 dbSNP
rs957410933 1507 dbSNP
rs1194047833 1513 dbSNP
rs1033031609 1525 dbSNP
rs1486728987 1529 dbSNP
rs1221288198 1530 dbSNP
rs1045095450 1533 dbSNP
rs1239965695 1534 dbSNP
rs548154573 1538 dbSNP
rs190399139 1543 dbSNP
rs1274501504 1552 dbSNP
rs1211339775 1556 dbSNP
rs1046101509 1557 dbSNP
rs1170997972 1560 dbSNP
rs1131970 1563 dbSNP
rs1398186185 1570 dbSNP
rs1216648817 1572 dbSNP
rs1322671026 1573 dbSNP
rs1360336092 1576 dbSNP
rs1014089373 1578 dbSNP
rs1296211948 1579 dbSNP
rs1339998340 1581 dbSNP
rs1219290261 1583 dbSNP
rs935154613 1586 dbSNP
rs924728124 1589 dbSNP
rs1270027188 1590 dbSNP
rs1291078226 1591 dbSNP
rs1453636913 1593 dbSNP
rs1437413078 1596 dbSNP
rs1215148674 1597 dbSNP
rs1487717047 1609 dbSNP
rs556939317 1609 dbSNP
rs934036302 1610 dbSNP
rs1374239372 1615 dbSNP
rs1397048546 1617 dbSNP
rs1162236602 1625 dbSNP
rs1414282770 1631 dbSNP
rs749370789 1638 dbSNP
rs186341461 1641 dbSNP
rs1461002428 1655 dbSNP
rs1393557880 1664 dbSNP
rs1400752153 1666 dbSNP
rs975390479 1675 dbSNP
rs1338704414 1682 dbSNP
rs1284980147 1689 dbSNP
rs1055523962 1691 dbSNP
rs1362091315 1710 dbSNP
rs962981452 1710 dbSNP
rs546025524 1717 dbSNP
rs982982218 1718 dbSNP
rs898934925 1730 dbSNP
rs181983530 1739 dbSNP
rs1219348257 1741 dbSNP
rs1263263888 1742 dbSNP
rs1036098733 1754 dbSNP
rs1186456725 1763 dbSNP
rs144214322 1766 dbSNP
rs1446286483 1770 dbSNP
rs911558432 1778 dbSNP
rs1035560500 1780 dbSNP
rs1420234288 1781 dbSNP
rs1211203776 1782 dbSNP
rs1003307191 1785 dbSNP
rs1413948620 1787 dbSNP
rs1335183266 1791 dbSNP
rs1467661717 1794 dbSNP
rs1385252830 1798 dbSNP
rs1444768455 1806 dbSNP
rs537371594 1808 dbSNP
rs934194534 1815 dbSNP
rs12317 1817 dbSNP
rs1010513737 1819 dbSNP
rs1478658864 1820 dbSNP
rs935208423 1820 dbSNP
rs975553877 1820 dbSNP
rs890304452 1821 dbSNP
rs1440054228 1828 dbSNP
rs957506277 1829 dbSNP
rs1306305244 1832 dbSNP
rs750390492 1836 dbSNP
rs554930804 1843 dbSNP
rs1489557558 1849 dbSNP
rs1373401765 1850 dbSNP
rs967787464 1855 dbSNP
rs534585274 1857 dbSNP
rs962063517 1860 dbSNP
rs1377774987 1863 dbSNP
rs1014138646 1868 dbSNP
rs1463434326 1869 dbSNP
rs1401542887 1870 dbSNP
rs572113059 1874 dbSNP
rs1393466851 1882 dbSNP
rs894374106 1886 dbSNP
rs558618842 1891 dbSNP
rs1331014833 1895 dbSNP
rs1234532078 1899 dbSNP
rs1034212841 1901 dbSNP
rs189229558 1911 dbSNP
rs1256995245 1912 dbSNP
rs1480875209 1915 dbSNP
rs983035958 1921 dbSNP
rs951686342 1926 dbSNP
rs757027555 1936 dbSNP
rs1432531772 1943 dbSNP
rs898989357 1949 dbSNP
rs1036559841 1957 dbSNP
rs1396466913 1964 dbSNP
rs1191382886 1966 dbSNP
rs751187998 1967 dbSNP
rs569744847 1999 dbSNP
rs928171600 2003 dbSNP
rs982669650 2008 dbSNP
rs1463901034 2017 dbSNP
rs890125288 2018 dbSNP
rs561356231 2031 dbSNP
rs763661611 2044 dbSNP
rs1390383637 2046 dbSNP
rs186133841 2068 dbSNP
rs1178493482 2071 dbSNP
rs921536168 2076 dbSNP
rs975647169 2085 dbSNP
rs1216251152 2090 dbSNP
rs1010564772 2095 dbSNP
rs568395654 2099 dbSNP
rs926104980 2100 dbSNP
rs7639380 2102 dbSNP
rs1488008853 2104 dbSNP
rs1350545404 2107 dbSNP
rs999413665 2108 dbSNP
rs890347566 2122 dbSNP
rs368724304 2124 dbSNP
rs1051630367 2132 dbSNP
rs1278402881 2144 dbSNP
rs1233813101 2147 dbSNP
rs1262441512 2156 dbSNP
rs1430524606 2158 dbSNP
rs1354739069 2159 dbSNP
rs1368273755 2167 dbSNP
rs1458713207 2168 dbSNP
rs1166093128 2173 dbSNP
rs1309220720 2179 dbSNP
rs1359173032 2190 dbSNP
rs967461515 2194 dbSNP
rs1297050403 2195 dbSNP
rs528462013 2203 dbSNP
rs992813568 2204 dbSNP
rs775127343 2211 dbSNP
rs113706392 2215 dbSNP
rs868045065 2227 dbSNP
rs1293930942 2236 dbSNP
rs180847558 2254 dbSNP
rs1171565952 2264 dbSNP
rs77820313 2268 dbSNP
rs1180387459 2269 dbSNP
rs1255733100 2290 dbSNP
rs761235542 2293 dbSNP
rs982333910 2299 dbSNP
rs1185827058 2301 dbSNP
rs563826946 2307 dbSNP
rs1378781980 2309 dbSNP
rs367982303 2310 dbSNP
rs773639623 2319 dbSNP
rs1416799659 2320 dbSNP
rs1407845156 2321 dbSNP
rs772431339 2327 dbSNP
rs1454867760 2329 dbSNP
rs916707167 2331 dbSNP
rs1377969557 2335 dbSNP
rs1189301596 2336 dbSNP
rs1486969797 2337 dbSNP
rs1374330054 2339 dbSNP
rs1014725493 2350 dbSNP
rs1239363690 2350 dbSNP
rs377051198 2356 dbSNP
rs989196382 2357 dbSNP
rs574718809 2358 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aacAGGUGAAGAAGGACGGGAc 5'
             ||| || ||  ||||||| 
Target 5' cucUCCCCUCCU--CUGCCCUg 3'
6 - 25
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_016201 | 3UTR | UACUGGGGUAGCAACUGACAGCUCAGAAAGGAGCUGAGCUCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_016201 | 3UTR | GCUACUGGGGUAGCAACUGACAGCUCAGAAAGGAGCUGAGCUCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_016201 | 3UTR | AGAAAGGAGCUGAGCUCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_016201 | 3UTR | UUGCCCAAGGCCUGCUACUGGGGUAGCAACUGACAGCUCAGAAAGGAGCUGAGCUCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_016201 | 3UTR | UCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_016201 | 3UTR | GAGCUGAGCUCCCUCUGCCCUGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000249883.5 | 3UTR | CCAUUCUCUCCCCUCCUCUGCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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