pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ABHD14B   
Synonyms CIB, HEL-S-299
Description abhydrolase domain containing 14B
Transcript NM_001146314   
Other Transcripts NM_032750   
Expression
Putative miRNA Targets on ABHD14B
3'UTR of ABHD14B
(miRNA target sites are highlighted)
>ABHD14B|NM_001146314|3'UTR
   1 AGCCCAGCACTGCTGCAGGGGGTGGGCTGCCTGCCTGCTCTGAGCTCTCTCTTGCACGCTCTCTCTTCTCTCCCAGGCTC
  81 TGGCTCATGCACATGCAACAGGTGCGTCTGTCTATATGTCTGGGTTCTTGTCTTTTGTGGTCTGTTTGTCTTTTCTACCT
 161 CTTTCTCTTGCAGTGATAGACTGAGGGGGTAAAATCAAGAGAAAAAACTCTCAGGAATCAAGGAACATAATCCTGTGGAG
 241 GGTAATCCATTACATGAGCTTCTCCTGTTCTTCCACTTTCCTGCCTGGCTTTCACTCCTTCCCCTGCTCTGCCCAGCCTT
 321 TCCCTCCCACCCACTCCTCCTTCTGCAAATGCCCTGAAGGCCAGCCCTTACCCCAACACCCACTTCCCCACCTCCTTAGG
 401 CCCCAGATACATACATGCCCACATGCACGCTTACATGTTTAGAGCCATCCTTGTTTCCAAATATGACCCTTCGCTTGAGG
 481 GCAACTGCATAGGTACATCTAACTCTGGACTGGCATGCACATTGTCATGTGCAGCTTTGCATATACACACATGCATACAT
 561 GAGCCTCCACACAAGCACTTGCACACATGTGGACTCCTAACCATGCTAACCTCACTGGCTGGGAAGGTGGGGACCCCATG
 641 GGCCAGCCCTTGCAGGAGGCCCTTTTGCAAGGCTTAGGGTGTGGCCAGCCCTGAAAGCTACTTGGACACAGGTTTCAGCT
 721 GGCCCCAGCCCAGAAGTGACCCCCAGAAAGGGAGGGCCACCGCTTTGCCCCCTGCTTTTACCCTTCCTTCTGGGTGCTCT
 801 ACACCTCAGGTTACCAGGCCTGAGGCATCTCAGCCAAGCTTGTTTCCTGCTCTGAGGCTTGTGGGGTGGGAGCCAGAGTG
 881 GAGGTCGGTGAAATAAAGTGATGCAATTAGACCCCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggGGUGGAAA---A-GAAGGGGg 5'
            |:: ||||   | ||||||| 
Target 5' gcCTGGCTTTCACTCCTTCCCCt 3'
283 - 305 149.00 -18.80
2
miRNA  3' gggGUGGAAAAGAAGGGGg 5'
             ||||    ||||||| 
Target 5' caaCACC--CACTTCCCCa 3'
374 - 390 144.00 -17.60
3
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            :| ||| ||||||| | 
Target 5' ctTCTCCTGTTCTTCCACt 3'
259 - 277 133.00 -15.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1083441 58 COSMIC
COSN30537934 63 COSMIC
COSN31494292 99 COSMIC
COSN30535579 105 COSMIC
COSN30459597 142 COSMIC
COSN31557601 241 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752198689 1 dbSNP
rs13065840 7 dbSNP
rs1452310984 8 dbSNP
rs756572566 14 dbSNP
rs1157807598 16 dbSNP
rs1482793950 17 dbSNP
rs750856153 18 dbSNP
rs531693557 19 dbSNP
rs996187468 20 dbSNP
rs762131634 21 dbSNP
rs1259132411 23 dbSNP
rs373861935 23 dbSNP
rs774863132 24 dbSNP
rs561132482 26 dbSNP
rs11549093 31 dbSNP
rs1430877546 33 dbSNP
rs1233110653 37 dbSNP
rs763030954 41 dbSNP
rs1358986316 42 dbSNP
rs370154891 44 dbSNP
rs1298319456 47 dbSNP
rs901141237 49 dbSNP
rs112901597 51 dbSNP
rs1358794369 53 dbSNP
rs1465364774 57 dbSNP
rs945487488 58 dbSNP
rs1213786593 59 dbSNP
rs1342434842 60 dbSNP
rs893879179 61 dbSNP
rs1299067680 63 dbSNP
rs929809160 65 dbSNP
rs1038145575 67 dbSNP
rs898305176 67 dbSNP
rs924384620 68 dbSNP
rs1215441497 90 dbSNP
rs1263348853 91 dbSNP
rs1476089904 92 dbSNP
rs1190010288 93 dbSNP
rs1219530807 94 dbSNP
rs141410429 98 dbSNP
rs981546207 100 dbSNP
rs949742287 104 dbSNP
rs749481598 105 dbSNP
rs926896777 106 dbSNP
rs989043100 112 dbSNP
rs982736076 114 dbSNP
rs1347080416 116 dbSNP
rs554393538 125 dbSNP
rs545646468 126 dbSNP
rs1366751076 130 dbSNP
rs1234759337 135 dbSNP
rs577965858 136 dbSNP
rs972371455 144 dbSNP
rs974861947 146 dbSNP
rs1428115998 148 dbSNP
rs139042255 149 dbSNP
rs1218661794 150 dbSNP
rs964800462 150 dbSNP
rs1246642464 158 dbSNP
rs1489132106 159 dbSNP
rs1196035485 160 dbSNP
rs961152578 162 dbSNP
rs146139089 164 dbSNP
rs1019026930 172 dbSNP
rs1159509267 173 dbSNP
rs1410377166 178 dbSNP
rs1393682622 186 dbSNP
rs1016693129 189 dbSNP
rs1009316050 190 dbSNP
rs538164945 206 dbSNP
rs1164095524 208 dbSNP
rs1211389642 208 dbSNP
rs1450606830 212 dbSNP
rs1441623734 213 dbSNP
rs1327818429 215 dbSNP
rs983959151 222 dbSNP
rs569586839 223 dbSNP
rs142968135 225 dbSNP
rs756115158 234 dbSNP
rs1445703231 235 dbSNP
rs1390175081 243 dbSNP
rs950715326 249 dbSNP
rs1226254236 260 dbSNP
rs1484285525 261 dbSNP
rs1216138659 267 dbSNP
rs1321768945 267 dbSNP
rs1236844193 271 dbSNP
rs1179588364 283 dbSNP
rs1457618596 283 dbSNP
rs1348187777 298 dbSNP
rs953980410 301 dbSNP
rs1181486496 302 dbSNP
rs752766225 303 dbSNP
rs1209716494 304 dbSNP
rs1485191991 305 dbSNP
rs770547007 309 dbSNP
rs552509750 310 dbSNP
rs191579484 312 dbSNP
rs371776541 313 dbSNP
rs1337296847 316 dbSNP
rs1342773473 326 dbSNP
rs994076784 331 dbSNP
rs998488166 337 dbSNP
rs1355578221 340 dbSNP
rs898398529 342 dbSNP
rs1303017861 344 dbSNP
rs1413765418 355 dbSNP
rs2109636 364 dbSNP
rs1317775578 369 dbSNP
rs1196887125 377 dbSNP
rs1275627636 378 dbSNP
rs1441029566 379 dbSNP
rs901071978 383 dbSNP
rs1038237946 386 dbSNP
rs1001359207 389 dbSNP
rs905648568 399 dbSNP
rs1045443324 400 dbSNP
rs1354403261 403 dbSNP
rs565469673 407 dbSNP
rs1168957567 412 dbSNP
rs1168404747 414 dbSNP
rs1398413773 416 dbSNP
rs949759542 422 dbSNP
rs912868038 424 dbSNP
rs1375617179 425 dbSNP
rs1416095292 427 dbSNP
rs1020940884 428 dbSNP
rs1009514848 429 dbSNP
rs1228860256 434 dbSNP
rs1474329687 436 dbSNP
rs1272405080 452 dbSNP
rs547165633 472 dbSNP
rs1218945407 480 dbSNP
rs1053797521 481 dbSNP
rs1486812911 484 dbSNP
rs1214708225 485 dbSNP
rs1262628724 487 dbSNP
rs1206961751 495 dbSNP
rs138386847 498 dbSNP
rs571366095 499 dbSNP
rs974922302 501 dbSNP
rs1202387627 516 dbSNP
rs1323481465 519 dbSNP
rs938200285 522 dbSNP
rs116629706 524 dbSNP
rs1046659365 528 dbSNP
rs949690416 532 dbSNP
rs919494844 533 dbSNP
rs1353167499 534 dbSNP
rs1436267335 536 dbSNP
rs1295943237 541 dbSNP
rs1359392538 542 dbSNP
rs1382261311 550 dbSNP
rs1320863634 552 dbSNP
rs186340387 563 dbSNP
rs1036739501 575 dbSNP
rs1373095350 580 dbSNP
rs1350475011 587 dbSNP
rs987547546 588 dbSNP
rs143091242 597 dbSNP
rs1351521204 605 dbSNP
rs772679926 611 dbSNP
rs1206916417 621 dbSNP
rs1263770990 634 dbSNP
rs1449861875 637 dbSNP
rs909643017 640 dbSNP
rs994828169 669 dbSNP
rs748426488 670 dbSNP
rs1455400201 681 dbSNP
rs1156493936 682 dbSNP
rs1379239991 687 dbSNP
rs1453855666 690 dbSNP
rs1159859262 698 dbSNP
rs983844832 700 dbSNP
rs1387931706 702 dbSNP
rs1459874930 709 dbSNP
rs1351013749 710 dbSNP
rs1373689985 712 dbSNP
rs1164296714 719 dbSNP
rs962651991 724 dbSNP
rs1016857375 725 dbSNP
rs1414381656 727 dbSNP
rs1183205853 728 dbSNP
rs953921838 729 dbSNP
rs921121979 731 dbSNP
rs1308820103 738 dbSNP
rs1419406834 738 dbSNP
rs1336510727 739 dbSNP
rs1249532047 746 dbSNP
rs1001369210 750 dbSNP
rs1175307261 751 dbSNP
rs1045903486 752 dbSNP
rs1059420 759 dbSNP
rs1273699878 762 dbSNP
rs1469671405 763 dbSNP
rs149492727 767 dbSNP
rs1249547270 786 dbSNP
rs1059425 790 dbSNP
rs891519965 794 dbSNP
rs1183504118 798 dbSNP
rs1059431 799 dbSNP
rs965708677 804 dbSNP
rs1460429953 806 dbSNP
rs16336 808 dbSNP
rs60739587 808 dbSNP
rs1020824588 813 dbSNP
rs1464398368 814 dbSNP
rs1009526162 815 dbSNP
rs957996443 818 dbSNP
rs1310812983 819 dbSNP
rs1339980520 820 dbSNP
rs549435427 823 dbSNP
rs1032399995 824 dbSNP
rs1059435 829 dbSNP
rs1039227717 837 dbSNP
rs527765787 839 dbSNP
rs912042362 847 dbSNP
rs368042575 849 dbSNP
rs1059439 852 dbSNP
rs1480818149 853 dbSNP
rs545533998 861 dbSNP
rs1305264958 865 dbSNP
rs76508138 872 dbSNP
rs919326174 873 dbSNP
rs1325832945 881 dbSNP
rs1474602035 884 dbSNP
rs1047028146 889 dbSNP
rs1013753489 896 dbSNP
rs898084189 904 dbSNP
rs1419384638 905 dbSNP
rs1036584766 909 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gggguGGAA---AAGAAGGGGg 5'
               |:||   | ||||||| 
Target 5' -----CUUUCACUCCUUCCCCu 3'
1 - 17
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000483233.1 | 3UTR | CUUUCACUCCUUCCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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