miRTarBase - #MIRT482632


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pre-miRNA Information
pre-miRNA hsa-mir-4794   
Genomic Coordinates chr1: 64579847 - 64579923
Description Homo sapiens miR-4794 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4794
Sequence 9| UCUGGCUAUCUCACGAGACUGU |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1162954002 4 dbSNP
rs1349204197 5 dbSNP
rs1454714841 8 dbSNP
rs191156964 14 dbSNP
rs543526824 15 dbSNP
rs1284724491 19 dbSNP
rs945565778 19 dbSNP
Putative Targets

Gene Information
Gene Symbol AAR2   
Synonyms C20orf4, CGI-23
Description AAR2 splicing factor homolog
Transcript NM_015511   
Expression
Putative miRNA Targets on AAR2
3'UTR of AAR2
(miRNA target sites are highlighted)		 
>AAR2|NM_015511|3'UTR
   1 CTCGGGGAGCGCTCTCAGCTGCGAGGGGCCCCTTCCCACAGGGCTGCAGTCCTGGCCTCTCCATTTACTTCTTCCCATCC
  81 TGGGACCTGCCAGGGCAGCAATCTCTCCAGGTCCTGCAAAGATGGAGCCAGAATTCCCTTTTTCACTGATAAATATATTT
 161 CTTCATTGCCAAAGAGGCTGTACCCATCCTGAAGGCACATTTGTGGGTTCCCCATCAGCCAGGCCTTGGTGCTAACCTGG
 241 CTGAATTTCACACAGGCTCTTACACACACACGCTCCTAGGAGACATCTGCCTACACGGCAACCATATTTCCTCTGAATGA
 321 GAAGGAATTGAACCAAAAGTCCAAGAAAGAACTGATTGCTTGTTCCATAGGAGCTTAGGAAACAAGAAACCCTGGATTGC
 401 CCAGGGGGTCTGAGAAGTTGGTTGGTGACTTTTTTTGCGGTTAAATGAAGGGTGATGGGGAGATCAGCCCGAATTGCCGC
 481 CTGCCTCTTGCTAAATAGGAGCAGAGGACTTGGCCTGCAGCTCCTTGGGAGCCCTTGATTGGGAAGAGAGTTTCAAGGGA
 561 GGCAGCTGGATTCAATCTAGCAGGTGGTCAGCTTCAGCTTTCTCCATCGAAATCCCATTCTCCTGTCCAGAGGCCCAGTG
 641 GGTCATCTCCCAAGGTGGGTGTGGACCCTGGCCTCAGAGGCCTTGCTGGTGCTGTCACCTCCCACCTGTTCCATTCCGAG
 721 GCCTCACCCAGAAGTGGGACCCTCCCCTTCCTCACCAGAGCCACCGTGACTGTTTCTGATGACCTGGAGAGTCAACAACA
 801 ACCAGAAAGGTTTCTGCCCAGAGCAGGCTTCTTAAGGCCTTTACGAAGTTTTGTGCCTTCCAAGTGCTGAAGAAGACCTG
 881 GTCAGCCTAAATCTTCCCAGTCCCGCTGTGGAGCTGTCAGTCACCGGAGTAATGAGCTCCTGGTTCCTCGGGAGTCCTTC
 961 GTGCTGTGTGGCAGGGTTCCTCTCTAGACAAGTACACAGGCCCTGCCACCCTGACATCAAACTGTTGTACTATGATCACA
1041 GTCCCTGTGCCATCCTTTTCCAAGACTGGGGCTCACACCATGTTTTTGAATGAGAATCCCTGCTGGTTGAGACTTTTGCT
1121 TCCACTTGTTTCCTTGGAGATGTTTTTCCAAGAGCATAATGTACATTAAAGTCTTCGAGTTGAGACAATCCCCTTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUCAGAGCACUCUAUCGGUCu 5'
            | ||| |  ||:|:|:||| 
Target 5' tcAATCTAG-CAGGTGGTCAGc 3'
 572 - 592 127.00 -14.70
2 
miRNA  3' ugucaGAGCACUC------UA-UCGGUCu 5'
               :|:|||:|      || |||||| 
Target 5' gcacaTTTGTGGGTTCCCCATCAGCCAGg 3'
 195 - 223 123.00 -16.40
3 
miRNA  3' ugucagagcacucuaUCGGUCu 5'
                         |||||| 
Target 5' gtcctgcaaagatggAGCCAGa 3'
 111 - 132 120.00 -14.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31564075 4 COSMIC
COSN30150360 8 COSMIC
COSN30124281 12 COSMIC
COSN30104236 26 COSMIC
COSN30451467 37 COSMIC
COSN30104139 57 COSMIC
COSN30451500 75 COSMIC
COSN30503105 83 COSMIC
COSN30163859 102 COSMIC
COSN10014978 576 COSMIC
COSN10014979 650 COSMIC
COSN7090169 718 COSMIC
COSN23636090 904 COSMIC
COSN31482495 951 COSMIC
COSN22357907 1002 COSMIC
COSN31595257 1069 COSMIC
COSN31548351 1177 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs140898327 2 dbSNP
rs777375580 4 dbSNP
rs748891907 5 dbSNP
rs1293537517 7 dbSNP
rs770584423 11 dbSNP
rs145177324 12 dbSNP
rs1278829782 14 dbSNP
rs745720221 15 dbSNP
rs1376104812 20 dbSNP
rs6060875 23 dbSNP
rs371729424 24 dbSNP
rs1251730956 25 dbSNP
rs1483381618 28 dbSNP
rs1484253340 29 dbSNP
rs868222154 37 dbSNP
rs760695575 38 dbSNP
rs1204120253 42 dbSNP
rs768567345 47 dbSNP
rs374971319 48 dbSNP
rs762055624 52 dbSNP
rs1234801510 60 dbSNP
rs1345526526 62 dbSNP
rs1287684482 63 dbSNP
rs1407870937 72 dbSNP
rs867053825 76 dbSNP
rs969901075 80 dbSNP
rs978639815 82 dbSNP
rs982181329 89 dbSNP
rs11905241 91 dbSNP
rs1400348348 93 dbSNP
rs938473447 97 dbSNP
rs1303326823 102 dbSNP
rs1480820865 109 dbSNP
rs936882146 112 dbSNP
rs1401468639 120 dbSNP
rs989748921 128 dbSNP
rs1473880643 144 dbSNP
rs1053028653 165 dbSNP
rs77987617 170 dbSNP
rs560393190 175 dbSNP
rs947315322 178 dbSNP
rs1308965213 179 dbSNP
rs111273847 180 dbSNP
rs932337515 183 dbSNP
rs113640620 185 dbSNP
rs1238902514 186 dbSNP
rs1352337317 189 dbSNP
rs6142538 195 dbSNP
rs900146276 199 dbSNP
rs995910667 204 dbSNP
rs527827325 207 dbSNP
rs1051432623 209 dbSNP
rs890857350 214 dbSNP
rs890641256 223 dbSNP
rs1004967043 226 dbSNP
rs116242468 232 dbSNP
rs1470452458 241 dbSNP
rs6142539 256 dbSNP
rs1388141602 257 dbSNP
rs1458876156 262 dbSNP
rs575347370 262 dbSNP
rs531850680 264 dbSNP
rs1024087375 268 dbSNP
rs1184571202 269 dbSNP
rs1461524873 271 dbSNP
rs550084068 272 dbSNP
rs775084293 276 dbSNP
rs1458507771 279 dbSNP
rs6142540 280 dbSNP
rs1227623604 284 dbSNP
rs1026936643 286 dbSNP
rs1285772122 295 dbSNP
rs1453093042 297 dbSNP
rs895136578 298 dbSNP
rs982212361 305 dbSNP
rs571457545 306 dbSNP
rs1437373977 307 dbSNP
rs1345823139 316 dbSNP
rs1035065579 318 dbSNP
rs779439341 319 dbSNP
rs1416556477 320 dbSNP
rs1455626180 329 dbSNP
rs11905177 340 dbSNP
rs1376995166 344 dbSNP
rs1464423490 345 dbSNP
rs913060957 350 dbSNP
rs368205533 358 dbSNP
rs1299830057 359 dbSNP
rs970756074 363 dbSNP
rs1242242308 366 dbSNP
rs79591555 367 dbSNP
rs191945018 368 dbSNP
rs978687650 372 dbSNP
rs1449860570 376 dbSNP
rs6142541 379 dbSNP
rs1031546473 388 dbSNP
rs1328836865 392 dbSNP
rs752248537 394 dbSNP
rs958268565 403 dbSNP
rs1341114837 404 dbSNP
rs1372789640 407 dbSNP
rs990128031 409 dbSNP
rs1230824921 417 dbSNP
rs1386836536 418 dbSNP
rs1362896625 421 dbSNP
rs1293060396 422 dbSNP
rs922204304 423 dbSNP
rs373070008 439 dbSNP
rs1304206573 445 dbSNP
rs931625701 454 dbSNP
rs536376312 455 dbSNP
rs554254954 456 dbSNP
rs34605647 457 dbSNP
rs985096621 458 dbSNP
rs890238371 466 dbSNP
rs940441350 471 dbSNP
rs377427841 472 dbSNP
rs1036963373 479 dbSNP
rs757904257 480 dbSNP
rs995512570 481 dbSNP
rs943747492 486 dbSNP
rs1272274825 497 dbSNP
rs748815248 500 dbSNP
rs1308373899 503 dbSNP
rs1300836241 518 dbSNP
rs1036823486 523 dbSNP
rs777417362 528 dbSNP
rs1284506020 530 dbSNP
rs1236566682 538 dbSNP
rs1409798261 545 dbSNP
rs1470046610 558 dbSNP
rs1310308631 563 dbSNP
rs79957201 575 dbSNP
rs1266690664 576 dbSNP
rs375292935 587 dbSNP
rs1174836701 596 dbSNP
rs1354765284 596 dbSNP
rs1431535762 597 dbSNP
rs1430983030 599 dbSNP
rs1430731273 600 dbSNP
rs1199484050 603 dbSNP
rs770798686 609 dbSNP
rs1249527722 610 dbSNP
rs895043182 613 dbSNP
rs1480805783 618 dbSNP
rs1208218836 620 dbSNP
rs183368210 620 dbSNP
rs1325895490 626 dbSNP
rs1424299557 634 dbSNP
rs1227849831 636 dbSNP
rs1035009139 641 dbSNP
rs956812482 642 dbSNP
rs1392347969 651 dbSNP
rs988223017 659 dbSNP
rs1396411890 660 dbSNP
rs1020563840 666 dbSNP
rs1436675251 666 dbSNP
rs1301928886 668 dbSNP
rs1464265733 671 dbSNP
rs968551081 674 dbSNP
rs35221435 679 dbSNP
rs374624042 699 dbSNP
rs1383453740 700 dbSNP
rs1000014282 702 dbSNP
rs143633037 704 dbSNP
rs1031115390 717 dbSNP
rs1280622294 718 dbSNP
rs958431272 719 dbSNP
rs1255267653 724 dbSNP
rs1011054116 730 dbSNP
rs1179882740 739 dbSNP
rs572430858 761 dbSNP
rs987138120 766 dbSNP
rs1208192210 767 dbSNP
rs911540894 769 dbSNP
rs940465261 771 dbSNP
rs1036085719 774 dbSNP
rs1321609668 782 dbSNP
rs1222523793 788 dbSNP
rs1366444796 806 dbSNP
rs1311090131 811 dbSNP
rs899349994 822 dbSNP
rs1454903573 825 dbSNP
rs745695081 843 dbSNP
rs75999961 845 dbSNP
rs905475372 846 dbSNP
rs1003792466 848 dbSNP
rs1382097118 854 dbSNP
rs189172134 858 dbSNP
rs1477495816 860 dbSNP
rs892456911 867 dbSNP
rs918365388 869 dbSNP
rs1454294786 874 dbSNP
rs931074478 878 dbSNP
rs773086039 881 dbSNP
rs576030543 888 dbSNP
rs1162512333 891 dbSNP
rs1419692868 891 dbSNP
rs1386109949 894 dbSNP
rs1188112871 897 dbSNP
rs1048186108 905 dbSNP
rs1263995431 906 dbSNP
rs775343783 926 dbSNP
rs916421308 927 dbSNP
rs1264196740 930 dbSNP
rs1248627071 931 dbSNP
rs543666856 934 dbSNP
rs766314553 942 dbSNP
rs1227271403 943 dbSNP
rs148113773 944 dbSNP
rs999998681 950 dbSNP
rs1028781467 956 dbSNP
rs953319800 961 dbSNP
rs1382296957 976 dbSNP
rs1298347843 979 dbSNP
rs987336821 997 dbSNP
rs911571912 998 dbSNP
rs961714682 1004 dbSNP
rs1426341677 1019 dbSNP
rs1276881965 1022 dbSNP
rs972228537 1033 dbSNP
rs143897891 1035 dbSNP
rs999558386 1036 dbSNP
rs1052883561 1046 dbSNP
rs563856113 1048 dbSNP
rs1194074327 1050 dbSNP
rs930383350 1052 dbSNP
rs893865271 1060 dbSNP
rs1265894671 1067 dbSNP
rs1312255784 1082 dbSNP
rs1045295016 1083 dbSNP
rs773448019 1092 dbSNP
rs926757386 1095 dbSNP
rs1011417823 1103 dbSNP
rs1320207520 1107 dbSNP
rs528207207 1108 dbSNP
rs752705324 1110 dbSNP
rs1227539050 1114 dbSNP
rs1329954753 1119 dbSNP
rs147409413 1125 dbSNP
rs1406739489 1129 dbSNP
rs1366087246 1132 dbSNP
rs892488251 1138 dbSNP
rs1307244792 1140 dbSNP
rs1407994989 1142 dbSNP
rs1398909552 1149 dbSNP
rs1214303855 1150 dbSNP
rs754171775 1158 dbSNP
rs1259577135 1172 dbSNP
rs759962744 1174 dbSNP
rs191025203 1177 dbSNP
rs138146353 1178 dbSNP
rs903970595 1180 dbSNP
rs569626535 1187 dbSNP
rs1420434946 1189 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000320849.4 | 3UTR | AAUUCCCUUUUUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
110 hsa-miR-4794 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059821 EFNA1 ephrin A1 2 2
MIRT203153 BACH1 BTB domain and CNC homolog 1 2 2
MIRT334253 SERPINH1 serpin family H member 1 2 2
MIRT475239 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 2
MIRT482467 ADAR adenosine deaminase, RNA specific 2 4
MIRT482632 AAR2 AAR2 splicing factor homolog 2 2
MIRT511147 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT514416 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT514842 LYRM7 LYR motif containing 7 2 4
MIRT515343 CXorf36 chromosome X open reading frame 36 2 2
MIRT515806 ALOX5AP arachidonate 5-lipoxygenase activating protein 2 2
MIRT516396 NPR1 natriuretic peptide receptor 1 2 4
MIRT516622 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT516959 SLC35F6 solute carrier family 35 member F6 2 2
MIRT517154 VHLL VHL like 2 2
MIRT517268 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT517660 TRIM72 tripartite motif containing 72 2 4
MIRT518026 ABHD15 abhydrolase domain containing 15 2 2
MIRT518116 RNMTL1 mitochondrial rRNA methyltransferase 3 2 4
MIRT518143 C15orf40 chromosome 15 open reading frame 40 2 4
MIRT518232 C7orf55 formation of mitochondrial complex V assembly factor 1 homolog 2 2
MIRT518517 CASP10 caspase 10 2 2
MIRT518646 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT519287 SPCS1 signal peptidase complex subunit 1 2 2
MIRT519487 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT520917 ST13 ST13, Hsp70 interacting protein 2 2
MIRT520928 SSBP2 single stranded DNA binding protein 2 2 2
MIRT521966 PHAX phosphorylated adaptor for RNA export 2 4
MIRT522244 NPFFR1 neuropeptide FF receptor 1 2 2
MIRT523355 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT525181 ZNF468 zinc finger protein 468 2 2
MIRT528221 METTL8 methyltransferase like 8 2 2
MIRT528437 COL9A2 collagen type IX alpha 2 chain 2 2
MIRT531504 NONO non-POU domain containing octamer binding 2 2
MIRT532597 SIX4 SIX homeobox 4 2 2
MIRT532761 LDHD lactate dehydrogenase D 2 2
MIRT536012 MECP2 methyl-CpG binding protein 2 2 2
MIRT536262 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547555 LRRC58 leucine rich repeat containing 58 2 2
MIRT554691 RNF2 ring finger protein 2 2 2
MIRT557250 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT563339 RPLP0 ribosomal protein lateral stalk subunit P0 2 2
MIRT573179 P2RX3 purinergic receptor P2X 3 2 2
MIRT574386 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT574638 LPCAT3 lysophosphatidylcholine acyltransferase 3 2 2
MIRT609143 ZNF610 zinc finger protein 610 2 4
MIRT609651 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT610846 ZNF44 zinc finger protein 44 2 2
MIRT612345 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT613002 GATA6 GATA binding protein 6 2 2
MIRT614095 PDE4C phosphodiesterase 4C 2 2
MIRT615512 AGTRAP angiotensin II receptor associated protein 2 2
MIRT621281 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT623367 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 2 2
MIRT624508 C7orf55-LUC7L2 C7orf55-LUC7L2 readthrough 2 2
MIRT632570 POLQ DNA polymerase theta 2 2
MIRT634829 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT639452 CTNNBL1 catenin beta like 1 2 2
MIRT642097 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT648408 TRMT10B tRNA methyltransferase 10B 2 2
MIRT653936 SERPINC1 serpin family C member 1 2 2
MIRT658226 FBXL16 F-box and leucine rich repeat protein 16 2 2
MIRT662599 MAGEB4 MAGE family member B4 2 2
MIRT663190 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT664623 DNPEP aspartyl aminopeptidase 2 2
MIRT671879 ZNF429 zinc finger protein 429 2 2
MIRT679033 ZNF419 zinc finger protein 419 2 2
MIRT684892 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT685153 DTWD2 DTW domain containing 2 2 2
MIRT686415 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT687021 RNF24 ring finger protein 24 2 2
MIRT688369 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT689600 FAM96A family with sequence similarity 96 member A 2 2
MIRT690375 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690484 RSRC1 arginine and serine rich coiled-coil 1 2 2
MIRT691458 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691861 ZNF552 zinc finger protein 552 2 2
MIRT692035 ARSK arylsulfatase family member K 2 2
MIRT693951 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT694058 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT694469 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695028 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695093 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 2
MIRT696624 WDR77 WD repeat domain 77 2 2
MIRT697446 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT697871 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT700637 PQLC2 PQ loop repeat containing 2 2 2
MIRT701192 OTUD3 OTU deubiquitinase 3 2 2
MIRT701332 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702199 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702891 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT704389 CTSS cathepsin S 2 2
MIRT704922 CCDC36 coiled-coil domain containing 36 2 2
MIRT705770 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT705797 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT705874 AEN apoptosis enhancing nuclease 2 2
MIRT707372 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707426 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710293 SPN sialophorin 2 2
MIRT710744 ZNF71 zinc finger protein 71 2 2
MIRT713183 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT715030 RANBP6 RAN binding protein 6 2 2
MIRT715829 ZNF598 zinc finger protein 598 2 2
MIRT720340 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT722662 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT722683 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT723908 PEX11A peroxisomal biogenesis factor 11 alpha 2 2
MIRT724044 SMIM14 small integral membrane protein 14 2 2
MIRT725241 PDE1B phosphodiesterase 1B 2 2
MIRT725307 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4794 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR4)

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