miRTarBase - #MIRT483070


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pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EXT2   
Synonyms SOTV, SSMS
Description exostosin glycosyltransferase 2
Transcript NM_207122   
Other Transcripts NM_001178083 , NM_000401   
Expression
Putative miRNA Targets on EXT2
3'UTR of EXT2
(miRNA target sites are highlighted)		 
>EXT2|NM_207122|3'UTR
   1 AACGTGTCATTGGTGGAGGTCTGAATGTGAGGCTGGGACAGAGGGAGAGAACAAGGCCTCCCAGCACTCTGATGTCAGAG
  81 TAGTAGGTTAAGGGTGGAAGGTTGACCTACTTGGATCTTGGCATGCACCCACCTAACCCACTTTCTCAAGAACAAGAACC
 161 TAGAATGAATATCCAAGCACCTCGAGCTATGCAACCTCTGTTCTTGTATTTCTTATGATCTCTGATGGGTTCTTCTCGAA
 241 AATGCCAAGTGGAAGACTTTGTGGCATGCTCCAGATTTAAATCCAGCTGAGGCTCCCTTTGTTTTCAGTTCCATGTAACA
 321 ATCTGGAAGGAAACTTCACGGACAGGAAGACTGCTGGAGAAGAGAAGCGTGTTAGCCCATTTGAGGTCTGGGGAATCATG
 401 TAAAGGGTACCCAGACCTCACTTTTAGTTATTTACATCAATGAGTTCTTTCAGGGAACCAAACCCAGAATTCGGTGCAAA
 481 AGCCAAACATCTTGGTGGGATTTGATAAATGCCTTGGGACCTGGAGTGCTGGGCTTGTGCACAGGAAGAGCACCAGCCGC
 561 TGAGTCAGGATCCTGTCAGTTCCATGAGCTATTCCTCTTTGGTTTGGCTTTTTGATATGATTAAAATTATTTTTTATTCC
 641 TTTTTCTACTGTGTCTTAAACACCAATTCCTGATAGTCCAAGGAACCACCTTTCTCCCTTGATATATTTAACTCCGTCTT
 721 TGGCCTGACAACAGTCTTCTGCCCATGTCTGGGAACACACGCCAGGAGGAATGTCTGATACCCTCTGCATCAAGCGTAAG
 801 AAGGTCCCAAATCATAACCATTTTAAGAACAGATGACTCAGAAACCTCCAGAGGAATCTGTTTGCTTCCTGATTAGATCC
 881 AGTCAATGTTTTAAAGGTATTGTCAGAGAAAAACAGAGGGTCTGTACTAGCCATGCAAGGAGTCGCTCTAGCTGGTACCC
 961 GTAAAAGTTGTGGGAATTGTGACCCCCATCCCAAGGGGATGCCAAAATTTCTCTCATTCTTTTGGTATAAACTTAACATT
1041 AGCCAGGGAGGTTCTGGCTAACGTTAAATGCTGCTATACAACTGCTTTGCAACAGTTGCTGGTATATTTAAATCATTAAA
1121 TTTCAGCATTTACTAATACTGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaCAGGUG-AAGAAGGACGGGac 5'
            | | ||  |||| ||||||  
Target 5' ctGACAACAGTCTT-CTGCCCat 3'
 725 - 746 135.00 -13.50
2 
miRNA  3' aacaGGUGAAGAAGGACGGGAc 5'
              ||||  |||:|| ||:| 
Target 5' ggaaCCAC--CTTTCTCCCTTg 3'
 682 - 701 118.00 -18.00
3 
miRNA  3' aaCAGGUGAAGAAG-------GACGGGAc 5'
            ||: | | || |       ||||::| 
Target 5' acGTTAAATGCTGCTATACAACTGCTTTg 3'
 1061 - 1089 112.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
304595 4 ClinVar
263285 57 ClinVar
304596 94 ClinVar
304597 102 ClinVar
304598 130 ClinVar
304599 140 ClinVar
878225 340 ClinVar
304600 369 ClinVar
304601 382 ClinVar
879676 441 ClinVar
304602 473 ClinVar
304603 647 ClinVar
879677 673 ClinVar
304604 732 ClinVar
304605 796 ClinVar
304606 803 ClinVar
880042 839 ClinVar
880043 863 ClinVar
880044 883 ClinVar
304607 946 ClinVar
368960 1154 ClinVar
COSN31506513 17 COSMIC
COSN30178678 32 COSMIC
COSN31785790 50 COSMIC
COSN20053080 57 COSMIC
COSN31560292 59 COSMIC
COSN30465448 61 COSMIC
COSN31503632 75 COSMIC
COSN31567098 221 COSMIC
COSN20309955 441 COSMIC
COSN7009166 505 COSMIC
COSN30172308 903 COSMIC
COSN31568875 909 COSMIC
COSN30172397 982 COSMIC
COSN31521393 1063 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757675605 2 dbSNP
rs542907948 4 dbSNP
rs200718123 5 dbSNP
rs758883253 7 dbSNP
rs780700112 8 dbSNP
rs533079651 9 dbSNP
rs1333272014 10 dbSNP
rs150146973 11 dbSNP
rs754477934 14 dbSNP
rs781012977 23 dbSNP
rs371927874 28 dbSNP
rs1238029664 31 dbSNP
rs769466476 32 dbSNP
rs772940123 37 dbSNP
rs749107045 38 dbSNP
rs770781132 39 dbSNP
rs774218901 40 dbSNP
rs760770173 48 dbSNP
rs764122969 50 dbSNP
rs1403924121 54 dbSNP
rs951202138 56 dbSNP
rs77554103 57 dbSNP
rs995515994 59 dbSNP
rs928349883 61 dbSNP
rs138627468 63 dbSNP
rs886048278 94 dbSNP
rs1370575468 101 dbSNP
rs117755165 102 dbSNP
rs1009108834 112 dbSNP
rs1353530327 125 dbSNP
rs1442001179 128 dbSNP
rs141864253 130 dbSNP
rs1194294338 134 dbSNP
rs191451519 140 dbSNP
rs916179389 142 dbSNP
rs371153847 151 dbSNP
rs1019031954 154 dbSNP
rs956803129 170 dbSNP
rs1043210344 174 dbSNP
rs988139543 174 dbSNP
rs184812009 181 dbSNP
rs1360382210 184 dbSNP
rs1227042430 185 dbSNP
rs1408989929 192 dbSNP
rs1370377798 197 dbSNP
rs776828352 203 dbSNP
rs1314944774 210 dbSNP
rs549675187 216 dbSNP
rs968634217 223 dbSNP
rs903346053 229 dbSNP
rs998981166 239 dbSNP
rs776347610 249 dbSNP
rs1052265897 261 dbSNP
rs1473206678 266 dbSNP
rs747662877 267 dbSNP
rs1239276052 269 dbSNP
rs1272811342 276 dbSNP
rs979096220 293 dbSNP
rs567830977 295 dbSNP
rs535054355 302 dbSNP
rs927091376 314 dbSNP
rs577809863 316 dbSNP
rs1356921483 322 dbSNP
rs1289143744 332 dbSNP
rs759615273 340 dbSNP
rs553383263 341 dbSNP
rs1471777417 351 dbSNP
rs772938456 352 dbSNP
rs1056928511 355 dbSNP
rs1007582666 356 dbSNP
rs1412072761 357 dbSNP
rs886048279 369 dbSNP
rs1364101732 377 dbSNP
rs886048280 382 dbSNP
rs1406426206 394 dbSNP
rs1388088238 396 dbSNP
rs762471785 403 dbSNP
rs1156916030 412 dbSNP
rs1450839137 413 dbSNP
rs963963968 420 dbSNP
rs995421316 425 dbSNP
rs1252817572 426 dbSNP
rs1166151642 431 dbSNP
rs1418381346 435 dbSNP
rs940460387 437 dbSNP
rs529075674 441 dbSNP
rs1361317049 445 dbSNP
rs1222267762 464 dbSNP
rs951278641 472 dbSNP
rs74424177 473 dbSNP
rs539143548 474 dbSNP
rs995060073 478 dbSNP
rs1366527108 487 dbSNP
rs1329162969 492 dbSNP
rs1050663721 498 dbSNP
rs889405561 499 dbSNP
rs1009054449 500 dbSNP
rs1293337368 503 dbSNP
rs1437565548 511 dbSNP
rs557442509 527 dbSNP
rs1804678 529 dbSNP
rs1019145363 531 dbSNP
rs1338985707 539 dbSNP
rs1219986144 549 dbSNP
rs1412777347 551 dbSNP
rs978528150 553 dbSNP
rs959790403 559 dbSNP
rs760089548 560 dbSNP
rs1424678442 569 dbSNP
rs956751266 573 dbSNP
rs373704488 576 dbSNP
rs991125964 585 dbSNP
rs915539760 595 dbSNP
rs542423403 597 dbSNP
rs947677940 605 dbSNP
rs1186123609 618 dbSNP
rs978972748 632 dbSNP
rs1478162142 637 dbSNP
rs924830919 639 dbSNP
rs189528648 647 dbSNP
rs1221109298 652 dbSNP
rs1051914752 654 dbSNP
rs752771704 664 dbSNP
rs1220178315 665 dbSNP
rs1176092701 674 dbSNP
rs1390026647 675 dbSNP
rs1437852865 685 dbSNP
rs573030871 687 dbSNP
rs927207816 699 dbSNP
rs1358818964 704 dbSNP
rs1176977649 716 dbSNP
rs367728025 717 dbSNP
rs756244678 731 dbSNP
rs886048281 732 dbSNP
rs1325980171 733 dbSNP
rs992602462 746 dbSNP
rs1276896822 761 dbSNP
rs1201240696 762 dbSNP
rs59877575 766 dbSNP
rs1222684851 770 dbSNP
rs995452347 772 dbSNP
rs764042376 775 dbSNP
rs1268449851 784 dbSNP
rs1027300028 786 dbSNP
rs1331176802 794 dbSNP
rs76505631 796 dbSNP
rs1004468506 797 dbSNP
rs1228075493 797 dbSNP
rs1366587241 798 dbSNP
rs531942530 803 dbSNP
rs1035496469 804 dbSNP
rs1349179281 805 dbSNP
rs1378529249 811 dbSNP
rs1200360754 818 dbSNP
rs1303704500 821 dbSNP
rs757498191 822 dbSNP
rs1244637651 837 dbSNP
rs1368522608 838 dbSNP
rs991198189 839 dbSNP
rs1199187756 841 dbSNP
rs1430098720 849 dbSNP
rs780055642 855 dbSNP
rs968340115 856 dbSNP
rs1422788484 859 dbSNP
rs1256213496 860 dbSNP
rs1050116809 862 dbSNP
rs192098481 863 dbSNP
rs371480027 872 dbSNP
rs1204909381 873 dbSNP
rs1343237697 874 dbSNP
rs746796046 876 dbSNP
rs531153736 878 dbSNP
rs549298353 886 dbSNP
rs988053146 890 dbSNP
rs567979162 894 dbSNP
rs1313496393 896 dbSNP
rs944956435 898 dbSNP
rs943468516 915 dbSNP
rs535005349 920 dbSNP
rs1410274428 923 dbSNP
rs547273205 925 dbSNP
rs899189468 928 dbSNP
rs1406081418 935 dbSNP
rs930650718 936 dbSNP
rs892633950 938 dbSNP
rs755006263 945 dbSNP
rs886048282 946 dbSNP
rs1288770159 949 dbSNP
rs781252558 961 dbSNP
rs1004096995 962 dbSNP
rs1260136872 963 dbSNP
rs571669894 971 dbSNP
rs1254394628 975 dbSNP
rs1002148165 983 dbSNP
rs1488460481 994 dbSNP
rs747986917 995 dbSNP
rs895643419 998 dbSNP
rs1327154075 1001 dbSNP
rs1288023096 1002 dbSNP
rs1229219027 1010 dbSNP
rs1352139260 1016 dbSNP
rs1356895809 1025 dbSNP
rs1012646524 1039 dbSNP
rs1321376905 1046 dbSNP
rs1022650425 1064 dbSNP
rs968413889 1069 dbSNP
rs1295148318 1080 dbSNP
rs1000282595 1085 dbSNP
rs1031300185 1086 dbSNP
rs992718265 1104 dbSNP
rs1410570440 1108 dbSNP
rs1291823910 1122 dbSNP
rs1024051972 1125 dbSNP
rs1473352521 1130 dbSNP
rs956492710 1137 dbSNP
rs1490091120 1142 dbSNP
rs139144725 1146 dbSNP
rs987737232 1148 dbSNP
rs185285766 1154 dbSNP
rs964856715 1156 dbSNP
rs189837855 1170 dbSNP
rs920324995 1175 dbSNP
rs1180089435 1196 dbSNP
rs4755793 1198 dbSNP
rs748981264 1209 dbSNP
rs1267549316 1212 dbSNP
rs554463570 1214 dbSNP
rs1165101383 1215 dbSNP
rs117203434 1220 dbSNP
rs1232266207 1223 dbSNP
rs1048197430 1227 dbSNP
rs181122111 1230 dbSNP
rs907869951 1233 dbSNP
rs1432783414 1241 dbSNP
rs1372633474 1253 dbSNP
rs115936930 1263 dbSNP
rs944904348 1268 dbSNP
rs1399608620 1270 dbSNP
rs1040653065 1278 dbSNP
rs1477937446 1280 dbSNP
rs1378548473 1288 dbSNP
rs1057032877 1289 dbSNP
rs560707174 1291 dbSNP
rs945530789 1295 dbSNP
rs1043931514 1304 dbSNP
rs79978382 1320 dbSNP
rs1012720776 1322 dbSNP
rs1200079669 1326 dbSNP
rs1345515068 1327 dbSNP
rs1312806395 1328 dbSNP
rs1358157351 1335 dbSNP
rs1002262840 1338 dbSNP
rs543773612 1344 dbSNP
rs1276405911 1345 dbSNP
rs562639286 1360 dbSNP
rs999909320 1363 dbSNP
rs1031793186 1364 dbSNP
rs529733424 1371 dbSNP
rs1338174295 1372 dbSNP
rs1250205342 1382 dbSNP
rs1414649136 1383 dbSNP
rs759860386 1386 dbSNP
rs1175941239 1406 dbSNP
rs1428153617 1408 dbSNP
rs1443518429 1415 dbSNP
rs1186013734 1417 dbSNP
rs1383891082 1419 dbSNP
rs1024633824 1420 dbSNP
rs1235786700 1424 dbSNP
rs1187158670 1442 dbSNP
rs1019227519 1443 dbSNP
rs764626759 1446 dbSNP
rs543254283 1453 dbSNP
rs1341184957 1455 dbSNP
rs1392264891 1459 dbSNP
rs1275331409 1460 dbSNP
rs974917011 1461 dbSNP
rs1460624701 1463 dbSNP
rs868403590 1468 dbSNP
rs56084882 1474 dbSNP
rs142446942 1493 dbSNP
rs983550148 1495 dbSNP
rs1402709467 1497 dbSNP
rs7109033 1500 dbSNP
rs1334691009 1502 dbSNP
rs571932578 1515 dbSNP
rs1412103805 1516 dbSNP
rs1412214312 1524 dbSNP
rs910179089 1526 dbSNP
rs1056365994 1528 dbSNP
rs1420305776 1538 dbSNP
rs1180288851 1547 dbSNP
rs532584683 1551 dbSNP
rs917176301 1563 dbSNP
rs1252250946 1565 dbSNP
rs1305435869 1568 dbSNP
rs764248518 1570 dbSNP
rs1449826145 1573 dbSNP
rs34783168 1575 dbSNP
rs1044210957 1577 dbSNP
rs1228410008 1579 dbSNP
rs753850818 1583 dbSNP
rs757619514 1585 dbSNP
rs914129396 1586 dbSNP
rs904362793 1590 dbSNP
rs1346193579 1602 dbSNP
rs1044259732 1630 dbSNP
rs925488874 1638 dbSNP
rs1000385944 1650 dbSNP
rs1348647388 1650 dbSNP
rs1052855644 1660 dbSNP
rs1241852139 1670 dbSNP
rs1420079475 1670 dbSNP
rs1461209244 1672 dbSNP
rs143971236 1681 dbSNP
rs1472401440 1688 dbSNP
rs1008578754 1693 dbSNP
rs376559404 1701 dbSNP
rs1263887034 1705 dbSNP
rs1013526994 1717 dbSNP
rs1426790963 1724 dbSNP
rs115458936 1725 dbSNP
rs754502872 1726 dbSNP
rs1207494021 1729 dbSNP
rs1329468517 1732 dbSNP
rs900759699 1734 dbSNP
rs996430599 1739 dbSNP
rs1027861604 1758 dbSNP
rs952235873 1761 dbSNP
rs1308607820 1765 dbSNP
rs1225842190 1782 dbSNP
rs1365907577 1788 dbSNP
rs1274821943 1791 dbSNP
rs897710850 1792 dbSNP
rs114199477 1793 dbSNP
rs546775769 1798 dbSNP
rs1467444442 1802 dbSNP
rs1173914278 1803 dbSNP
rs1015025900 1812 dbSNP
rs1161538846 1817 dbSNP
rs186558290 1819 dbSNP
rs4755794 1821 dbSNP
rs1007440227 1838 dbSNP
rs1455549775 1854 dbSNP
rs574219596 1879 dbSNP
rs542830481 1884 dbSNP
rs1187391696 1885 dbSNP
rs1464907692 1886 dbSNP
rs1262180440 1913 dbSNP
rs916541911 1923 dbSNP
rs532356950 1924 dbSNP
rs36074639 1925 dbSNP
rs1321994941 1928 dbSNP
rs1017359303 1931 dbSNP
rs965816421 1940 dbSNP
rs1278390881 1944 dbSNP
rs948678047 1959 dbSNP
rs979980173 1962 dbSNP
rs1359313287 1963 dbSNP
rs533711295 1968 dbSNP
rs967335892 1973 dbSNP
rs1301620037 1974 dbSNP
rs1446059882 1975 dbSNP
rs935868187 1981 dbSNP
rs1358750853 1985 dbSNP
rs1174059788 1988 dbSNP
rs148643662 1991 dbSNP
rs142905413 1992 dbSNP
rs944416600 1996 dbSNP
rs1263197505 1997 dbSNP
rs1323483360 1998 dbSNP
rs1040104293 2013 dbSNP
rs900163869 2014 dbSNP
rs1055247587 2020 dbSNP
rs1237628251 2021 dbSNP
rs1212062925 2025 dbSNP
rs996461945 2032 dbSNP
rs1027887846 2035 dbSNP
rs780807231 2041 dbSNP
rs1308205320 2043 dbSNP
rs1262986198 2044 dbSNP
rs1394322366 2045 dbSNP
rs1378721884 2057 dbSNP
rs941548318 2059 dbSNP
rs1313650497 2079 dbSNP
rs1005062817 2080 dbSNP
rs748119065 2082 dbSNP
rs1268335314 2087 dbSNP
rs1307399564 2103 dbSNP
rs993780897 2104 dbSNP
rs1374687505 2110 dbSNP
rs543836186 2116 dbSNP
rs1422672094 2120 dbSNP
rs960824700 2142 dbSNP
rs1418197181 2148 dbSNP
rs1189621303 2154 dbSNP
rs992200347 2164 dbSNP
rs1023625882 2181 dbSNP
rs1197049531 2187 dbSNP
rs1481263467 2191 dbSNP
rs1428277608 2192 dbSNP
rs969347151 2198 dbSNP
rs979378265 2199 dbSNP
rs1321181816 2203 dbSNP
rs1294202422 2205 dbSNP
rs1235330787 2212 dbSNP
rs188037437 2216 dbSNP
rs925906744 2225 dbSNP
rs1391694290 2232 dbSNP
rs77475390 2233 dbSNP
rs1187543662 2238 dbSNP
rs887729874 2241 dbSNP
rs1394534526 2252 dbSNP
rs1166706503 2256 dbSNP
rs988664877 2262 dbSNP
rs1471418155 2263 dbSNP
rs913055078 2265 dbSNP
rs1410717337 2270 dbSNP
rs1007387952 2274 dbSNP
rs541562653 2279 dbSNP
rs1369327053 2292 dbSNP
rs1208570946 2299 dbSNP
rs560163544 2303 dbSNP
rs1245756510 2315 dbSNP
rs1488218887 2317 dbSNP
rs1273920591 2320 dbSNP
rs1215598492 2330 dbSNP
rs1327352442 2331 dbSNP
rs528708368 2338 dbSNP
rs372939864 2339 dbSNP
rs1040136765 2345 dbSNP
rs1239576718 2346 dbSNP
rs1402668496 2350 dbSNP
rs1299156841 2357 dbSNP
rs1386123240 2370 dbSNP
rs755944239 2377 dbSNP
rs1327368952 2384 dbSNP
rs1282219570 2386 dbSNP
rs1455122885 2387 dbSNP
rs931652040 2390 dbSNP
rs1049173582 2393 dbSNP
rs1454691476 2394 dbSNP
rs888042369 2410 dbSNP
rs1454249763 2414 dbSNP
rs1032542015 2415 dbSNP
rs1005505137 2420 dbSNP
rs1036570524 2424 dbSNP
rs778248242 2425 dbSNP
rs540812007 2428 dbSNP
rs180904177 2429 dbSNP
rs747551007 2441 dbSNP
rs114811255 2443 dbSNP
rs569196521 2444 dbSNP
rs777397121 2447 dbSNP
rs555470728 2453 dbSNP
rs949463302 2455 dbSNP
rs1357562277 2457 dbSNP
rs186184426 2464 dbSNP
rs1305458074 2471 dbSNP
rs190991346 2473 dbSNP
rs572059073 2474 dbSNP
rs116601742 2478 dbSNP
rs1472831736 2483 dbSNP
rs1171196563 2486 dbSNP
rs931323778 2494 dbSNP
rs183650940 2500 dbSNP
rs1176074661 2505 dbSNP
rs529723141 2519 dbSNP
rs1241571915 2523 dbSNP
rs1193931419 2524 dbSNP
rs1048904995 2529 dbSNP
rs1418394658 2536 dbSNP
rs887677724 2538 dbSNP
rs1000830448 2539 dbSNP
rs943288529 2541 dbSNP
rs566591827 2545 dbSNP
rs1226038931 2546 dbSNP
rs533773449 2552 dbSNP
rs957351507 2553 dbSNP
rs1366954838 2571 dbSNP
rs997637237 2572 dbSNP
rs1422183366 2580 dbSNP
rs989128513 2586 dbSNP
rs1338355484 2589 dbSNP
rs115964457 2591 dbSNP
rs563742256 2593 dbSNP
rs537742658 2594 dbSNP
rs1315424318 2595 dbSNP
rs1000517268 2601 dbSNP
rs1419377646 2609 dbSNP
rs1168571246 2611 dbSNP
rs1281569028 2613 dbSNP
rs556374266 2614 dbSNP
rs1168242567 2615 dbSNP
rs1476399997 2617 dbSNP
rs975887610 2621 dbSNP
rs1485897701 2631 dbSNP
rs1259325173 2640 dbSNP
rs1202695944 2653 dbSNP
rs527885712 2660 dbSNP
rs368812994 2662 dbSNP
rs1197098437 2664 dbSNP
rs1223667859 2667 dbSNP
rs1353643148 2669 dbSNP
rs1048723093 2673 dbSNP
rs151092026 2679 dbSNP
rs940986208 2680 dbSNP
rs1037008120 2692 dbSNP
rs1295534335 2701 dbSNP
rs1408316101 2709 dbSNP
rs1243861451 2712 dbSNP
rs553617055 2730 dbSNP
rs1483468760 2735 dbSNP
rs1013720158 2737 dbSNP
rs973344032 2742 dbSNP
rs918668289 2747 dbSNP
rs1164536647 2749 dbSNP
rs745484554 2754 dbSNP
rs931414090 2757 dbSNP
rs1179767716 2765 dbSNP
rs1182418115 2769 dbSNP
rs1469427989 2770 dbSNP
rs905289734 2772 dbSNP
rs1233457727 2786 dbSNP
rs572149221 2788 dbSNP
rs984100928 2796 dbSNP
rs1206505743 2799 dbSNP
rs1449425893 2810 dbSNP
rs943233079 2815 dbSNP
rs373595799 2831 dbSNP
rs868377016 2839 dbSNP
rs772435587 2841 dbSNP
rs1038972856 2847 dbSNP
rs1032379505 2849 dbSNP
rs1442303890 2858 dbSNP
rs933153776 2860 dbSNP
rs956910338 2863 dbSNP
rs1042636761 2866 dbSNP
rs540875635 2868 dbSNP
rs1461966013 2869 dbSNP
rs1411257650 2870 dbSNP
rs902236803 2871 dbSNP
rs1399939334 2883 dbSNP
rs1353170704 2887 dbSNP
rs1408417002 2889 dbSNP
rs1010179790 2890 dbSNP
rs565467983 2900 dbSNP
rs1020642223 2903 dbSNP
rs1001036346 2909 dbSNP
rs965920645 2913 dbSNP
rs186933779 2914 dbSNP
rs758316860 2917 dbSNP
rs1193727208 2927 dbSNP
rs1469406997 2941 dbSNP
rs975918805 2944 dbSNP
rs1316744674 2955 dbSNP
rs1385595785 2955 dbSNP
rs1450554952 2956 dbSNP
rs11421737 2957 dbSNP
rs1441826607 2957 dbSNP
rs562975624 2957 dbSNP
rs771809042 2957 dbSNP
rs865993578 2958 dbSNP
rs1430308296 2959 dbSNP
rs953145543 2963 dbSNP
rs1345969997 2965 dbSNP
rs1161029347 2977 dbSNP
rs1311669932 2978 dbSNP
rs1216601711 2980 dbSNP
rs894814453 2989 dbSNP
rs1394462553 2991 dbSNP
rs984938731 2994 dbSNP
rs1174180272 2997 dbSNP
rs908906362 3001 dbSNP
rs10550006 3014 dbSNP
rs1245641477 3014 dbSNP
rs796782413 3014 dbSNP
rs1243418850 3016 dbSNP
rs1486006057 3016 dbSNP
rs1218395817 3017 dbSNP
rs746872503 3017 dbSNP
rs1484894979 3018 dbSNP
rs1306774061 3020 dbSNP
rs529658811 3022 dbSNP
rs940332578 3028 dbSNP
rs1293562240 3032 dbSNP
rs1035999988 3033 dbSNP
rs918176961 3038 dbSNP
rs1362939442 3039 dbSNP
rs1459874042 3041 dbSNP
rs1412775278 3043 dbSNP
rs949599926 3049 dbSNP
rs1045247473 3050 dbSNP
rs1182477872 3056 dbSNP
rs1248049770 3064 dbSNP
rs1436525244 3073 dbSNP
rs191921540 3080 dbSNP
rs1165830073 3083 dbSNP
rs936800020 3099 dbSNP
rs543352319 3108 dbSNP
rs182794926 3109 dbSNP
rs187259149 3116 dbSNP
rs140974653 3120 dbSNP
rs1257290771 3121 dbSNP
rs1019590780 3125 dbSNP
rs1336627106 3138 dbSNP
rs527779309 3145 dbSNP
rs11368755 3155 dbSNP
rs1203988603 3155 dbSNP
rs397696239 3155 dbSNP
rs1327144114 3156 dbSNP
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rs1173840405 6909 dbSNP
rs869207966 6910 dbSNP
rs1376610236 6911 dbSNP
rs1453845455 6912 dbSNP
rs1429748154 6913 dbSNP
rs1253397916 6920 dbSNP
rs1202678737 6930 dbSNP
rs1018958047 6937 dbSNP
rs1159999350 6940 dbSNP
rs1264160922 6959 dbSNP
rs1205957113 6965 dbSNP
rs1039606539 6973 dbSNP
rs965638345 6979 dbSNP
rs1270096412 6990 dbSNP
rs1398545860 6991 dbSNP
rs899718130 6993 dbSNP
rs749750617 6997 dbSNP
rs931167236 6999 dbSNP
rs1048176255 7000 dbSNP
rs1297927572 7003 dbSNP
rs1328300620 7015 dbSNP
rs886898355 7016 dbSNP
rs770922462 7018 dbSNP
rs1315139811 7019 dbSNP
rs1452208614 7032 dbSNP
rs1010111676 7033 dbSNP
rs1338533529 7050 dbSNP
rs1463835516 7052 dbSNP
rs574227822 7056 dbSNP
rs1395745103 7057 dbSNP
rs1168443761 7076 dbSNP
rs1463422896 7078 dbSNP
rs895463726 7078 dbSNP
rs1020198019 7093 dbSNP
rs1012971824 7098 dbSNP
rs1182384536 7099 dbSNP
rs1444927146 7114 dbSNP
rs780922392 7116 dbSNP
rs535135255 7122 dbSNP
rs746137895 7124 dbSNP
rs553458965 7125 dbSNP
rs772280931 7137 dbSNP
rs1272682844 7147 dbSNP
rs1288437496 7157 dbSNP
rs1351734804 7185 dbSNP
rs1289757506 7192 dbSNP
rs1245330346 7193 dbSNP
rs956142735 7198 dbSNP
rs992875501 7199 dbSNP
rs987540424 7206 dbSNP
rs916931874 7210 dbSNP
rs911920771 7215 dbSNP
rs1334976897 7227 dbSNP
rs940885944 7229 dbSNP
rs79916850 7230 dbSNP
rs1162454243 7232 dbSNP
rs975114260 7236 dbSNP
rs189279378 7244 dbSNP
rs563625428 7250 dbSNP
rs1378129469 7252 dbSNP
rs1156484233 7254 dbSNP
rs1469274722 7259 dbSNP
rs931221283 7269 dbSNP
rs1050631801 7270 dbSNP
rs1440123289 7271 dbSNP
rs1350900397 7274 dbSNP
rs1459756786 7277 dbSNP
rs1048249713 7286 dbSNP
rs1008989645 7290 dbSNP
rs1293989851 7294 dbSNP
rs1222283325 7299 dbSNP
rs575442362 7301 dbSNP
rs1279984233 7304 dbSNP
rs181954236 7307 dbSNP
rs1009557229 7309 dbSNP
rs939794576 7313 dbSNP
rs1056825713 7315 dbSNP
rs895528549 7341 dbSNP
rs1366934196 7349 dbSNP
rs1374731195 7350 dbSNP
rs1295738075 7352 dbSNP
rs1399810529 7359 dbSNP
rs1408255795 7373 dbSNP
rs999963025 7375 dbSNP
rs1034200458 7394 dbSNP
rs528288704 7395 dbSNP
rs1199362403 7398 dbSNP
rs1490636567 7402 dbSNP
rs1271153103 7403 dbSNP
rs958668860 7419 dbSNP
rs992594486 7422 dbSNP
rs1023016370 7423 dbSNP
rs904814799 7434 dbSNP
rs1321182257 7435 dbSNP
rs1219038573 7437 dbSNP
rs1224054031 7442 dbSNP
rs1000442191 7443 dbSNP
rs1264798102 7446 dbSNP
rs560557916 7452 dbSNP
rs551954072 7457 dbSNP
rs1267965626 7462 dbSNP
rs764964978 7464 dbSNP
rs1429375711 7468 dbSNP
rs1480894241 7468 dbSNP
rs528030088 7469 dbSNP
rs1412357101 7475 dbSNP
rs1404366778 7479 dbSNP
rs1031873406 7482 dbSNP
rs1481085901 7484 dbSNP
rs1235872509 7487 dbSNP
rs1438538321 7489 dbSNP
rs971744900 7496 dbSNP
rs956175436 7503 dbSNP
rs1183882215 7509 dbSNP
rs1242727424 7512 dbSNP
rs987615453 7518 dbSNP
rs930894207 7519 dbSNP
rs1019036515 7520 dbSNP
rs1425934237 7527 dbSNP
rs1050996120 7532 dbSNP
rs1270771127 7543 dbSNP
rs965116865 7546 dbSNP
rs1213868985 7553 dbSNP
rs1163078003 7555 dbSNP
rs1271358695 7557 dbSNP
rs1450026551 7562 dbSNP
rs1381564515 7565 dbSNP
rs1349834987 7569 dbSNP
rs1336566289 7573 dbSNP
rs974810203 7575 dbSNP
rs1361462525 7577 dbSNP
rs7126447 7588 dbSNP
rs144335747 7589 dbSNP
rs1040452632 7593 dbSNP
rs983982404 7595 dbSNP
rs1446109577 7596 dbSNP
rs1242724546 7603 dbSNP
rs7126360 7606 dbSNP
rs1230919808 7608 dbSNP
rs550154139 7610 dbSNP
rs551662113 7613 dbSNP
rs570374944 7619 dbSNP
rs1203734065 7631 dbSNP
rs1009506367 7638 dbSNP
rs939868237 7639 dbSNP
rs531104037 7649 dbSNP
rs78133700 7650 dbSNP
rs1000126742 7665 dbSNP
rs187414025 7668 dbSNP
rs534989930 7670 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacagguGAAG---AAGGACGGGAc 5'
                 ||||   ||:||||||| 
Target 5' ----uuuCUUCAAAUUUCUGCCCUu 3'
 		1 - 21
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2132.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 PAR-CLIP data was present in ERX177609. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_11 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 5 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760641. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_B PAR-CLIP data was present in SRX1760591. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_B PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 PAR-CLIP data was present in SRX1760597. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_C PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000395673.3 | 3UTR | GUUUCUUCAAAUUUCUGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000395673.3 | 3UTR | UUUCUUCAAAUUUCUGCCCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000395673.3 | 3UTR | UUUCUUCAAAUUUCUGCCCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000395673.3 | 3UTR | UGGUUUCUUCAAAUUUCUGCCCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000395673.3 | 3UTR | GUUUCUUCAAAUUUCUGCCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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