miRTarBase - #MIRT483613


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pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-3p
Sequence 49| ACACACUUACCCGUAGAGAUUCUA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 2 - 56000739 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1032185572 4 dbSNP
rs1291886633 6 dbSNP
rs1195180466 10 dbSNP
rs761473579 10 dbSNP
rs751204276 12 dbSNP
rs368125248 13 dbSNP
rs755646560 13 dbSNP
rs1307586870 14 dbSNP
rs907200088 16 dbSNP
rs763696104 22 dbSNP
rs762699560 24 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol SMC5   
Synonyms SMC5L1
Description structural maintenance of chromosomes 5
Transcript NM_015110   
Expression
Putative miRNA Targets on SMC5
3'UTR of SMC5
(miRNA target sites are highlighted)		 
>SMC5|NM_015110|3'UTR
   1 TAAAAGTAAAGAGAGGGAACTTGGGAATTTTTTTTGTTAAATTCTGTTTATAAGTATGGCTCAACTGAATAAAAGGAGAT
  81 TCACTAAAACGAAAAGCAGTTATTTTTGGAAACCTGCTTTTAAATACAAATAGGTTGATAATGGAAACTATAATGACCTT
 161 TCCAAAATAGCAGCTGGTAGTAAAAGTTAAGTCTTCTTCAGTCTTGGTTGAACTTGAGTTCTTGGCACTCTGACCATGAG
 241 TCATTCAGTTCTCATGTTAAAATGTACTTAATATTACAAATCAAAGGTACAGTGGAAGAAGGGTTAATCACAAGAAGTTA
 321 CTTATATGGTAGCCCTGAGCTTTAATTGCAGAGTAACTTTAATTACTTTTAGAGCCTAAAGATGACTCTAGAGCCTAAGT
 401 CCTAGTTTCTCCCAATGTTATATTTAATTTTAAAAAATTGATATGAAAATGTCTAATGTATAGTAATAATTTATGACAGA
 481 TCTAGTCATTTCTTCCTATTAAAAAAGATTACCTTATCTCCAGTAGGAAATGGAATTTTATGGGCCTTTAAAAGAAAGTT
 561 TTATGAAACTTGATGCTATAATTTTATTGGTATTTCAAGGGGAAAAAAGCACTGGGGTTCAAAAATGGTAGCAGAACTGC
 641 TTTGAAATGCTGCAAGGTGGCCACTAGATGATGCAAAATACAACCAAAAGATTGACTGAGAATAAAATTAGGTGACAAGG
 721 GTTTTTAAAGAATAACCTTTTAAAGTGTGGGGGCAGGGGTTGCTTTTTTTTATTTTATTTAAAGTCAATTATATTTTACA
 801 TCTTACATTTCTAAAAGCATTTTATAATTATTTTTAGTAAGATTTTTCTTAAAATTTCATATACTGGTTTCTACAATTTA
 881 TATTTGAAATTTCTCAGTGTTATGTAAAGAGTGATGGAAAAGCATTGATTTCTTTAAAACCGTAATGTTTTTAGAACTTA
 961 AGCCTATAGGGCCTTTCTTACAATGTTGATGTACCCATTATCTTAGAAAATCTAGTTTAAACTGTTTTCTTTCACCGCAA
1041 AAGAATTAAATGGGAAAATCATTTGTTTATCTCTAAGTTATACTAATTAGTAGAACCAAACAAATTATCTTCTTTTAAAA
1121 AATAAATCTTATAGGAAAATAGACAGTCCAAAGTCATGTCTTTGAACAGTGGATTGGATCTGTGCCAGTAATGACAAAAT
1201 TATTTTTTTGACTTGCTTGCCTGAATAAATTGAAGAATTGCTTTCAGTTTGGGTTTTGTATATTCTTAAGTAGCCATTGA
1281 AATTTATATTCTTAACTAGGTCAAAAAATAATGAGCCATAAGTTTATGTCCTCTCACTTAGACATTTTCTCTTTAAAAAG
1361 GTATTTTCTTCTTTATAAACATTTTAAAAGAGCCTTCCCTTCTTAAACTAACTCCAGTGCATGAAGTGTGAAAATATTTT
1441 AAAATGACATTTTTACTAATATGAGCAAGTCATGTAAACATTGAAGAACTTGGTAACATATTAGTAAATGGATATTACCA
1521 AATGTTTTCATCGTTAATTACTTTGCGTTCCACCAAAATATCTTTACTAAAATGTGCTTGGTGTAGTTTGTTTATTGTCT
1601 AAATTAGTACCAGTCATCTTATTTCTGCAAAATGAGTATCAATGTGAAAAAGACACGTGAAGATTAAGCATGTTTGAAAA
1681 TAAAATGGTCAATTACATTTCAATTTACATAGGCCAACAACTGTTCCATACTTTGTTTGTAAACATTTAATTTCTCTACT
1761 GGACAAAATTAATATTTGGCTTTACATTGAATTTTGAGCTGTGAAGAATAAATTATGTATCATTTTAGCATATTAAACAG
1841 TAGTAAGTCTAGCACATAGTCTCAGCCACTTAAAACAAAAGTTTTTTTGTTTGTTTGTTTGTTTGTTTTTTTGAGATGGA
1921 GTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTTACTGCAACCTCCGCCTCCCGGGTTCAAGCGAT
2001 TCTCCTGCCTCAGCCTCCCAAGTAACTGGGACAACAGGCGCGTCCCACCACACCCAGCTAATTTTTTATACTTTTAGTAG
2081 AGATGGGGTTTCAGCATATTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGC
2161 TGGGATTATAGGCGTGAGCCCCTGCACCCGGCCAAAAGTTGATTTTTAATTACATAAAAATCGTAAAAACTTCTAGTAAA
2241 AACTTGATTTGGTGAATACAGTTATATTTAAAAACCTTAAGGTGACAAGCATTTTCTATGCCTAAATCTTCATTGGTTTG
2321 CCTGGAAAGAGTCTCTGTTAAAAGATTTTCCATATTCAAAGTAAAAGGAAAGATTTCTTGCTTTCTAATTGTCTTTTGGA
2401 CACATGCCTATTTTCTTTGAGGTATAAACCTTTAGATGTGAAAAATGTAATTTCATTCTGCTATTGTGTGTGCTTGTGTG
2481 TGTGTAATTGAAAAAACTGGGAAATCCTGCTTTGTTGGTAATAAATCAATATTTTTATATTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucuUAGAGAU-GCCCA-UUCACACa 5'
              | ||| | :|  | ||||||| 
Target 5' aactAACTCCAGTGCATGAAGTGTGa 3'
 1406 - 1431 148.00 -10.80
2 
miRNA  3' auCUUA----GAGAUGCCCAUUCACACa 5'
            ||||    :|:||     ||||||| 
Target 5' aaGAATAACCTTTTA-----AAGTGTGg 3'
 728 - 750 147.00 -10.50
3 
miRNA  3' aucUUAGAGAUGCCCAUUCACACa 5'
             || :|||::   ||||| || 
Target 5' gttAAATTCTGTTTATAAGTATGg 3'
 36 - 59 129.00 -6.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30103371 7 COSMIC
COSN30528057 11 COSMIC
COSN24955908 18 COSMIC
COSN31519926 31 COSMIC
COSN26995774 36 COSMIC
COSN30531169 79 COSMIC
COSN30480522 90 COSMIC
COSN14396803 91 COSMIC
COSN27618111 157 COSMIC
COSN28712416 213 COSMIC
COSN31525243 222 COSMIC
COSN9714497 287 COSMIC
COSN22510127 288 COSMIC
COSN27160598 626 COSMIC
COSN22754813 973 COSMIC
COSN26432227 1037 COSMIC
COSN32062136 1210 COSMIC
COSN2325757 1668 COSMIC
COSN18956614 1765 COSMIC
COSN17131486 1872 COSMIC
COSN16080838 1941 COSMIC
COSN2325758 2062 COSMIC
COSN17076273 2369 COSMIC
COSN2325759 2376 COSMIC
COSN7570491 2436 COSMIC
COSN26742741 2487 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768543488 2 dbSNP
rs777046420 3 dbSNP
rs762050283 4 dbSNP
rs367646838 5 dbSNP
rs773276906 13 dbSNP
rs1281541985 14 dbSNP
rs763384486 15 dbSNP
rs1477531907 17 dbSNP
rs777995132 21 dbSNP
rs1418409427 24 dbSNP
rs145145028 28 dbSNP
rs771295825 28 dbSNP
rs1011226017 33 dbSNP
rs759932263 36 dbSNP
rs767844726 42 dbSNP
rs1041374261 43 dbSNP
rs753454456 46 dbSNP
rs780752946 49 dbSNP
rs1337848782 53 dbSNP
rs1054024089 58 dbSNP
rs1353231811 59 dbSNP
rs1246563878 62 dbSNP
rs1281203164 65 dbSNP
rs893662507 70 dbSNP
rs902952889 72 dbSNP
rs945279793 73 dbSNP
rs867577540 91 dbSNP
rs183063929 92 dbSNP
rs1373272295 97 dbSNP
rs1172402473 98 dbSNP
rs1400769962 100 dbSNP
rs1409609943 128 dbSNP
rs953231654 130 dbSNP
rs906172981 134 dbSNP
rs575379576 136 dbSNP
rs1470116586 140 dbSNP
rs1488575787 149 dbSNP
rs1187012113 150 dbSNP
rs1007913685 151 dbSNP
rs1425289557 166 dbSNP
rs1016169832 171 dbSNP
rs1003172384 172 dbSNP
rs1279893360 177 dbSNP
rs545925805 184 dbSNP
rs1033387512 189 dbSNP
rs963598298 192 dbSNP
rs972110388 198 dbSNP
rs1328422702 208 dbSNP
rs557423359 211 dbSNP
rs1469741294 212 dbSNP
rs1353392960 217 dbSNP
rs970795657 221 dbSNP
rs572794164 233 dbSNP
rs529688422 237 dbSNP
rs142646144 241 dbSNP
rs1420818653 248 dbSNP
rs1312752410 252 dbSNP
rs1374060284 265 dbSNP
rs1156340386 266 dbSNP
rs1400592034 273 dbSNP
rs1398085160 277 dbSNP
rs530353241 301 dbSNP
rs1167475133 304 dbSNP
rs1313007681 308 dbSNP
rs1334795054 317 dbSNP
rs549551312 322 dbSNP
rs146901003 326 dbSNP
rs966000365 331 dbSNP
rs1487002259 340 dbSNP
rs563554288 349 dbSNP
rs1215195597 359 dbSNP
rs1310778146 359 dbSNP
rs1464335942 362 dbSNP
rs1273755059 371 dbSNP
rs1235130549 375 dbSNP
rs1332368408 385 dbSNP
rs749435761 387 dbSNP
rs1214744329 392 dbSNP
rs1363671870 400 dbSNP
rs1286538113 404 dbSNP
rs945594239 410 dbSNP
rs975139979 420 dbSNP
rs1210110699 421 dbSNP
rs1460378726 422 dbSNP
rs1417569189 423 dbSNP
rs1171588759 432 dbSNP
rs1430481879 432 dbSNP
rs1278012582 433 dbSNP
rs921993662 440 dbSNP
rs1041406346 442 dbSNP
rs902817120 452 dbSNP
rs1468961124 461 dbSNP
rs1200805334 464 dbSNP
rs1257206615 465 dbSNP
rs933090623 467 dbSNP
rs1215459956 475 dbSNP
rs530871604 478 dbSNP
rs1176905070 483 dbSNP
rs1382271669 490 dbSNP
rs1440353457 496 dbSNP
rs957664699 500 dbSNP
rs990277324 509 dbSNP
rs915045385 512 dbSNP
rs758331869 541 dbSNP
rs1051492888 551 dbSNP
rs888976652 558 dbSNP
rs1371056910 576 dbSNP
rs187066103 577 dbSNP
rs1305059954 585 dbSNP
rs1007406777 586 dbSNP
rs1299036091 594 dbSNP
rs1042253694 603 dbSNP
rs1376372362 610 dbSNP
rs1016489180 621 dbSNP
rs939312376 623 dbSNP
rs1055182059 632 dbSNP
rs1303790267 633 dbSNP
rs894840832 640 dbSNP
rs149357004 648 dbSNP
rs899085885 656 dbSNP
rs1177766581 667 dbSNP
rs1481488484 669 dbSNP
rs1249448086 679 dbSNP
rs993342828 684 dbSNP
rs779893506 685 dbSNP
rs1281795874 686 dbSNP
rs1332903268 693 dbSNP
rs1231446535 694 dbSNP
rs1330973788 706 dbSNP
rs1308323801 709 dbSNP
rs1026309701 712 dbSNP
rs970702251 720 dbSNP
rs73647489 722 dbSNP
rs1301225585 738 dbSNP
rs746775934 748 dbSNP
rs1435527060 749 dbSNP
rs1377502612 759 dbSNP
rs143189920 761 dbSNP
rs1313853911 764 dbSNP
rs966279438 764 dbSNP
rs374489736 765 dbSNP
rs1029393728 768 dbSNP
rs1250539698 771 dbSNP
rs528474534 772 dbSNP
rs546708293 773 dbSNP
rs1196990854 777 dbSNP
rs773856356 781 dbSNP
rs1485756849 786 dbSNP
rs1259199120 789 dbSNP
rs41287365 792 dbSNP
rs1343671014 795 dbSNP
rs913330094 802 dbSNP
rs1458288518 807 dbSNP
rs967471967 815 dbSNP
rs1288044691 816 dbSNP
rs1193061448 820 dbSNP
rs1415793859 822 dbSNP
rs1357818094 826 dbSNP
rs1311283674 827 dbSNP
rs977894167 842 dbSNP
rs535765758 843 dbSNP
rs927826141 859 dbSNP
rs1265926577 860 dbSNP
rs945657214 871 dbSNP
rs557154875 872 dbSNP
rs1475406304 874 dbSNP
rs776204459 876 dbSNP
rs1055064896 877 dbSNP
rs569078051 878 dbSNP
rs1051399673 882 dbSNP
rs191840058 896 dbSNP
rs557825365 898 dbSNP
rs764546599 903 dbSNP
rs886181094 904 dbSNP
rs1268035160 907 dbSNP
rs143517232 910 dbSNP
rs538576063 927 dbSNP
rs1291880275 933 dbSNP
rs1375457016 936 dbSNP
rs540203590 941 dbSNP
rs898984083 942 dbSNP
rs993413074 943 dbSNP
rs1026168278 947 dbSNP
rs1380618982 955 dbSNP
rs1388072976 963 dbSNP
rs902040076 965 dbSNP
rs148012537 967 dbSNP
rs996800316 967 dbSNP
rs1003514662 968 dbSNP
rs957568623 977 dbSNP
rs1034075148 986 dbSNP
rs112937700 987 dbSNP
rs574756371 989 dbSNP
rs1225466211 990 dbSNP
rs1307840854 992 dbSNP
rs1194950566 1001 dbSNP
rs1011572270 1003 dbSNP
rs1246920393 1025 dbSNP
rs989938421 1028 dbSNP
rs1214837126 1032 dbSNP
rs1022496061 1037 dbSNP
rs966866072 1038 dbSNP
rs763679958 1039 dbSNP
rs769506767 1040 dbSNP
rs558303560 1044 dbSNP
rs922861635 1055 dbSNP
rs1272132931 1062 dbSNP
rs1225605524 1069 dbSNP
rs967419493 1070 dbSNP
rs772699020 1076 dbSNP
rs754450946 1082 dbSNP
rs1318831007 1092 dbSNP
rs1321272985 1097 dbSNP
rs757850107 1102 dbSNP
rs987136228 1103 dbSNP
rs960590533 1107 dbSNP
rs1169251680 1115 dbSNP
rs910174661 1117 dbSNP
rs1245038404 1123 dbSNP
rs943165276 1125 dbSNP
rs762501815 1130 dbSNP
rs916508298 1131 dbSNP
rs1037852519 1133 dbSNP
rs765595236 1134 dbSNP
rs756835051 1141 dbSNP
rs766880259 1142 dbSNP
rs1221970740 1145 dbSNP
rs1275602109 1158 dbSNP
rs1047528625 1161 dbSNP
rs1341757533 1165 dbSNP
rs1477076829 1175 dbSNP
rs906480881 1189 dbSNP
rs1236602495 1196 dbSNP
rs774752759 1200 dbSNP
rs1368943064 1202 dbSNP
rs1272994473 1206 dbSNP
rs759896119 1213 dbSNP
rs1196263015 1222 dbSNP
rs1435718788 1223 dbSNP
rs907562858 1226 dbSNP
rs1055142213 1239 dbSNP
rs940406117 1243 dbSNP
rs1040158408 1250 dbSNP
rs895131295 1253 dbSNP
rs553478107 1258 dbSNP
rs1011031150 1261 dbSNP
rs1162194082 1263 dbSNP
rs1422530335 1268 dbSNP
rs1172475064 1271 dbSNP
rs1351122299 1278 dbSNP
rs1470828224 1283 dbSNP
rs1022783796 1285 dbSNP
rs1265355780 1291 dbSNP
rs966754708 1293 dbSNP
rs184260679 1298 dbSNP
rs1482818202 1300 dbSNP
rs1258471672 1301 dbSNP
rs34570873 1303 dbSNP
rs1051068952 1309 dbSNP
rs1288239754 1310 dbSNP
rs141667484 1316 dbSNP
rs1218522593 1319 dbSNP
rs1351354090 1320 dbSNP
rs1012266976 1328 dbSNP
rs189570983 1344 dbSNP
rs986106893 1345 dbSNP
rs1313107099 1362 dbSNP
rs1278599493 1364 dbSNP
rs910255806 1365 dbSNP
rs1232909726 1372 dbSNP
rs1020230875 1376 dbSNP
rs60551452 1384 dbSNP
rs973204336 1389 dbSNP
rs193096307 1392 dbSNP
rs1472466051 1394 dbSNP
rs1222375159 1399 dbSNP
rs1260699312 1405 dbSNP
rs920361184 1405 dbSNP
rs929036281 1406 dbSNP
rs1487593181 1414 dbSNP
rs1482410664 1417 dbSNP
rs1002891229 1420 dbSNP
rs763306591 1431 dbSNP
rs1035740445 1434 dbSNP
rs960789306 1438 dbSNP
rs1047558393 1442 dbSNP
rs990660361 1450 dbSNP
rs1328189211 1458 dbSNP
rs1293734401 1461 dbSNP
rs927768690 1466 dbSNP
rs939307285 1467 dbSNP
rs1475047115 1472 dbSNP
rs753179606 1479 dbSNP
rs3739772 1494 dbSNP
rs951978154 1502 dbSNP
rs528601534 1522 dbSNP
rs1430805411 1525 dbSNP
rs984733634 1530 dbSNP
rs1319093823 1531 dbSNP
rs546940847 1533 dbSNP
rs1167588158 1534 dbSNP
rs1422218306 1534 dbSNP
rs1043708313 1538 dbSNP
rs1413364922 1538 dbSNP
rs185859261 1542 dbSNP
rs1157694729 1545 dbSNP
rs1358618417 1547 dbSNP
rs376514213 1548 dbSNP
rs975787947 1559 dbSNP
rs756391221 1562 dbSNP
rs1421425901 1563 dbSNP
rs1223508931 1569 dbSNP
rs1319763167 1570 dbSNP
rs1298668819 1585 dbSNP
rs1214833436 1586 dbSNP
rs764458632 1600 dbSNP
rs1294796491 1601 dbSNP
rs1374627259 1607 dbSNP
rs923040142 1611 dbSNP
rs1445484324 1614 dbSNP
rs189366221 1622 dbSNP
rs1295597358 1623 dbSNP
rs1282697387 1626 dbSNP
rs1381580727 1632 dbSNP
rs999575281 1650 dbSNP
rs1229033440 1655 dbSNP
rs1306371589 1657 dbSNP
rs150510501 1658 dbSNP
rs576438572 1658 dbSNP
rs1351529742 1662 dbSNP
rs1411918432 1663 dbSNP
rs1219440485 1673 dbSNP
rs955520203 1694 dbSNP
rs750547937 1697 dbSNP
rs1253530641 1698 dbSNP
rs1192914945 1704 dbSNP
rs1487362863 1710 dbSNP
rs1007164464 1721 dbSNP
rs1204718013 1724 dbSNP
rs753936970 1729 dbSNP
rs1271774021 1732 dbSNP
rs903153283 1732 dbSNP
rs1348053508 1733 dbSNP
rs962966454 1735 dbSNP
rs1238884152 1739 dbSNP
rs1483370115 1746 dbSNP
rs1176180441 1752 dbSNP
rs1367323699 1757 dbSNP
rs1377960357 1765 dbSNP
rs1440926847 1767 dbSNP
rs1159208457 1770 dbSNP
rs1168256226 1773 dbSNP
rs539604831 1774 dbSNP
rs1379482994 1776 dbSNP
rs1027239879 1779 dbSNP
rs1036133675 1788 dbSNP
rs894557752 1800 dbSNP
rs1412588646 1807 dbSNP
rs1013440720 1811 dbSNP
rs950480698 1816 dbSNP
rs181379743 1818 dbSNP
rs983156466 1829 dbSNP
rs1335935824 1831 dbSNP
rs1249149539 1832 dbSNP
rs1361180186 1832 dbSNP
rs1204087245 1843 dbSNP
rs1257298407 1844 dbSNP
rs566533534 1856 dbSNP
rs1231653013 1857 dbSNP
rs1312158879 1861 dbSNP
rs927840843 1867 dbSNP
rs951983800 1872 dbSNP
rs939163832 1879 dbSNP
rs1307615718 1882 dbSNP
rs1349087113 1882 dbSNP
rs60673535 1882 dbSNP
rs766493986 1882 dbSNP
rs1014850073 1886 dbSNP
rs1377010229 1886 dbSNP
rs1404383991 1886 dbSNP
rs759659073 1886 dbSNP
rs565553911 1890 dbSNP
rs1409536729 1893 dbSNP
rs534770353 1897 dbSNP
rs1242346603 1906 dbSNP
rs1485809819 1906 dbSNP
rs139442176 1910 dbSNP
rs986299743 1917 dbSNP
rs914723624 1922 dbSNP
rs1288137909 1949 dbSNP
rs1234088047 1951 dbSNP
rs1342489333 1956 dbSNP
rs185942691 1957 dbSNP
rs902506869 1964 dbSNP
rs746930313 1965 dbSNP
rs573303155 1978 dbSNP
rs1321107734 1981 dbSNP
rs1458801704 1982 dbSNP
rs537492846 1988 dbSNP
rs1158193868 1989 dbSNP
rs1313085551 1998 dbSNP
rs557219882 1999 dbSNP
rs1235932050 2003 dbSNP
rs1458728765 2007 dbSNP
rs1248155847 2015 dbSNP
rs1007480786 2023 dbSNP
rs1178685057 2025 dbSNP
rs924858438 2027 dbSNP
rs1018422857 2031 dbSNP
rs898748400 2040 dbSNP
rs575879810 2041 dbSNP
rs1174195363 2042 dbSNP
rs141896839 2043 dbSNP
rs564544333 2052 dbSNP
rs1425616769 2055 dbSNP
rs573250350 2056 dbSNP
rs1244391142 2060 dbSNP
rs1327078149 2062 dbSNP
rs1299945855 2069 dbSNP
rs540376697 2072 dbSNP
rs1362955217 2074 dbSNP
rs562211870 2075 dbSNP
rs1034719730 2084 dbSNP
rs1405729891 2086 dbSNP
rs894494649 2088 dbSNP
rs1161069628 2114 dbSNP
rs1457111198 2117 dbSNP
rs993015736 2138 dbSNP
rs1390209519 2140 dbSNP
rs1398350213 2141 dbSNP
rs41287367 2142 dbSNP
rs796315807 2146 dbSNP
rs551029591 2147 dbSNP
rs1453655758 2148 dbSNP
rs1434962345 2156 dbSNP
rs368685597 2157 dbSNP
rs1346184939 2162 dbSNP
rs559653757 2168 dbSNP
rs1276784276 2172 dbSNP
rs916381046 2174 dbSNP
rs139340116 2175 dbSNP
rs1014806774 2179 dbSNP
rs1332554329 2181 dbSNP
rs144105142 2187 dbSNP
rs1385807716 2189 dbSNP
rs923960334 2190 dbSNP
rs780371950 2191 dbSNP
rs1449309540 2215 dbSNP
rs997464752 2222 dbSNP
rs188403995 2223 dbSNP
rs747998756 2224 dbSNP
rs528618516 2226 dbSNP
rs985860138 2229 dbSNP
rs1198608320 2232 dbSNP
rs370059753 2234 dbSNP
rs914314015 2237 dbSNP
rs1254231993 2242 dbSNP
rs1247164669 2252 dbSNP
rs1482755795 2254 dbSNP
rs968474761 2261 dbSNP
rs1474989563 2263 dbSNP
rs977555625 2264 dbSNP
rs1052684 2271 dbSNP
rs938922852 2279 dbSNP
rs1232241373 2283 dbSNP
rs1467364846 2286 dbSNP
rs772894978 2288 dbSNP
rs76248783 2299 dbSNP
rs770372277 2305 dbSNP
rs898657464 2307 dbSNP
rs996201373 2309 dbSNP
rs948731020 2312 dbSNP
rs1048437589 2323 dbSNP
rs1332154490 2324 dbSNP
rs888522623 2334 dbSNP
rs1180223302 2345 dbSNP
rs1472403728 2349 dbSNP
rs1047285975 2364 dbSNP
rs1004325832 2370 dbSNP
rs1399857383 2384 dbSNP
rs1036186762 2397 dbSNP
rs1276688784 2403 dbSNP
rs886134687 2405 dbSNP
rs41287369 2408 dbSNP
rs1283199010 2411 dbSNP
rs1034608482 2412 dbSNP
rs1276409879 2416 dbSNP
rs1353673831 2422 dbSNP
rs960745421 2429 dbSNP
rs144985988 2431 dbSNP
rs1290011000 2436 dbSNP
rs1226147807 2448 dbSNP
rs1211085705 2455 dbSNP
rs1030666829 2458 dbSNP
rs1290556901 2464 dbSNP
rs1458247159 2471 dbSNP
rs747875455 2474 dbSNP
rs888753780 2477 dbSNP
rs537429721 2486 dbSNP
rs1391237198 2492 dbSNP
rs1157398622 2496 dbSNP
rs1472351580 2504 dbSNP
rs1487918998 2505 dbSNP
rs1007630787 2512 dbSNP
rs1021286077 2514 dbSNP
rs1214252636 2515 dbSNP
rs867019773 2530 dbSNP
rs968420294 2537 dbSNP
rs977169160 2538 dbSNP
rs1011989483 2540 dbSNP
rs1023927627 2543 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000361138.5 | 3UTR | AACUCCAGUGCAUGAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-216b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071722 CCNK cyclin K 2 2
MIRT074768 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT101407 SSR1 signal sequence receptor subunit 1 2 2
MIRT241289 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 4
MIRT268292 CCND1 cyclin D1 2 8
MIRT445347 IFNA6 interferon alpha 6 2 2
MIRT446663 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT447595 MSH3 mutS homolog 3 2 2
MIRT448485 SEMA4F ssemaphorin 4F 2 2
MIRT450309 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451850 TXNDC5 thioredoxin domain containing 5 2 2
MIRT483613 SMC5 structural maintenance of chromosomes 5 2 2
MIRT485633 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT499766 CIRH1A UTP4, small subunit processome component 2 6
MIRT503337 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT513007 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513529 RHOQ ras homolog family member Q 2 4
MIRT521499 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT524335 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT524731 BRI3BP BRI3 binding protein 2 8
MIRT525326 SNX29 sorting nexin 29 2 2
MIRT526264 CCDC169 coiled-coil domain containing 169 2 2
MIRT527428 NRL neural retina leucine zipper 2 2
MIRT527512 ZNF134 zinc finger protein 134 2 2
MIRT528881 ATF3 activating transcription factor 3 2 2
MIRT529578 IGBP1 immunoglobulin binding protein 1 2 4
MIRT531122 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT531341 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT532433 DHX33 DEAH-box helicase 33 2 2
MIRT534032 STX7 syntaxin 7 2 2
MIRT534538 SACS sacsin molecular chaperone 2 4
MIRT538886 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT539628 CD19 CD19 molecule 2 8
MIRT540327 ATAT1 alpha tubulin acetyltransferase 1 2 8
MIRT540353 OCLN occludin 2 6
MIRT540699 ATG10 autophagy related 10 2 4
MIRT541033 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT541945 NBPF10 NBPF member 10 2 4
MIRT543505 PLS1 plastin 1 2 2
MIRT551164 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT551790 ZNF117 zinc finger protein 117 2 4
MIRT553227 TWF1 twinfilin actin binding protein 1 2 2
MIRT559622 AKIRIN2 akirin 2 2 2
MIRT559719 ADORA2B adenosine A2b receptor 2 2
MIRT564600 ZNF781 zinc finger protein 781 2 2
MIRT567015 KLHL15 kelch like family member 15 2 2
MIRT569564 C7orf26 chromosome 7 open reading frame 26 2 2
MIRT572155 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT575399 Zdhhc22 zinc finger, DHHC-type containing 22 2 5
MIRT607322 PKNOX1 PBX/knotted 1 homeobox 1 2 4
MIRT607953 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT607979 ZDHHC22 zinc finger DHHC-type containing 22 2 7
MIRT609145 ZNF610 zinc finger protein 610 2 4
MIRT609206 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT609338 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT609725 KIF5C kinesin family member 5C 2 4
MIRT610014 MED24 mediator complex subunit 24 2 4
MIRT610407 TMEM245 transmembrane protein 245 2 2
MIRT610559 NBPF14 NBPF member 14 2 2
MIRT611291 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT611399 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT611432 C11orf45 chromosome 11 open reading frame 45 2 4
MIRT611710 SLFN13 schlafen family member 13 2 2
MIRT611721 ANK3 ankyrin 3 2 2
MIRT611830 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT611977 ZNF175 zinc finger protein 175 2 2
MIRT612073 CEP135 centrosomal protein 135 2 4
MIRT612195 CCDC77 coiled-coil domain containing 77 2 2
MIRT612320 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT612354 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT612635 PTEN phosphatase and tensin homolog 2 2
MIRT612773 MLXIP MLX interacting protein 2 4
MIRT612788 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT612853 JAZF1 JAZF zinc finger 1 2 2
MIRT612965 GID4 GID complex subunit 4 homolog 2 6
MIRT613132 DUSP6 dual specificity phosphatase 6 2 2
MIRT613388 AAK1 AP2 associated kinase 1 2 2
MIRT615058 CRY2 cryptochrome circadian clock 2 2 4
MIRT616046 HSPA12B heat shock protein family A (Hsp70) member 12B 2 2
MIRT617962 SEPT9 septin 9 2 2
MIRT618413 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 2
MIRT622448 RNF213 ring finger protein 213 2 2
MIRT623611 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT625709 SHROOM1 shroom family member 1 2 2
MIRT630646 ELK1 ELK1, ETS transcription factor 2 2
MIRT630970 KIAA2022 neurite extension and migration factor 2 2
MIRT631003 SPAG7 sperm associated antigen 7 2 2
MIRT640385 EMC1 ER membrane protein complex subunit 1 2 4
MIRT641064 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 2
MIRT641780 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT646310 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT646624 CENPL centromere protein L 2 2
MIRT659653 CDH2 cadherin 2 2 2
MIRT666161 SP1 Sp1 transcription factor 2 2
MIRT667638 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT668988 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT680949 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT695238 PBK PDZ binding kinase 2 2
MIRT700036 RPL22 ribosomal protein L22 2 2
MIRT707685 GPR50 G protein-coupled receptor 50 2 2
MIRT709324 HMBOX1 homeobox containing 1 2 2
MIRT710176 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT712007 F9 coagulation factor IX 2 2
MIRT714219 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT714496 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT714575 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT715982 TFRC transferrin receptor 2 2
MIRT717870 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT718289 MINA ribosomal oxygenase 2 2 2
MIRT725200 PTRF caveolae associated protein 1 2 2
MIRT737338 TPX2 TPX2, microtubule nucleation factor 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-216b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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