miRTarBase - #MIRT483643


—
pre-miRNA Information
pre-miRNA hsa-mir-4697   
Genomic Coordinates chr11: 133898504 - 133898581
Description Homo sapiens miR-4697 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4697-5p
Sequence 10| AGGGGGCGCAGUCACUGACGUG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs549326907 2 dbSNP
rs897782230 7 dbSNP
rs748950280 8 dbSNP
rs978998780 15 dbSNP
rs968922289 19 dbSNP
rs3802919 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol QSOX2   
Synonyms QSCN6L1, SOXN
Description quiescin sulfhydryl oxidase 2
Transcript NM_181701   
Expression
Putative miRNA Targets on QSOX2
3'UTR of QSOX2
(miRNA target sites are highlighted)		 
>QSOX2|NM_181701|3'UTR
   1 GTGCCCGGGTGCTGCCAGCCACGGCGGAAGCTCCCTTGGAGGCAGCCCTGCCCCGTGCCACCTGCAGCTTTAATATTTAT
  81 GATCAGGGATTTTATAAACATGCGGGCCTGGTTTCACATCGGATGGCACCTTTTGGCTTCAAAGTCCTGGTTTTACAAAC
 161 GCTCTTCTAACAAGGGAAGAACACGGGGTAATTTTGTGGGGATATTTGCATTCCTGGCGTACTCAAGTCTGTTCATGCTC
 241 CTTTTGCAGGTCTTACAGCAAAAAGACTTCTGTATTTTTACTCTTCTAGATGTGAAAAGAGGGTGCAGAGTCCAGGCCAG
 321 ATAGTCTTCCCCACACACTTTCATCTCGTTTCCTCCACTCCGCCCCATCCTGCAGGGCCTTGTTTTTGTATTTGGAGAAC
 401 CTCGCCCATCCCCCCCGCGGCTCCTGGCTCCCCCCCACTCCCCTCGCTCCCCCTCCCCCCGCTCCCCCCACGCCCCCTGC
 481 TCCAGGCTGCCAAGTGTTTTCCTTTAGCCGGGCGGGGACAGACAGAGCCGGAAGCGCAGTCGGCCTCTGCAGCCCCTCCA
 561 AGCAAGTGCTCCAGGGACTATCCTGTGTTTGTAGCTGCTTCCCTAGGGCAGGTTCCTGAGGGCTCTCCTTGTTCCTCCGG
 641 GTGTTCGACACCAGACGTGGGGATTTCAACAGGGGAGGAGCCAAGGAATTCTGTGGCTGTGCTGCGTTTCAGAAAATAAC
 721 CCCCAGAGGCCTTGGGCTGTGGACCTGGGGGTTGGAAGGATGGGGGCTCATTTAACCCTCAGAGGCAGCGCCTTTGTCTG
 801 TCTATCTGGTGACAAGAGAGAGACAAGTAAATGGGGGCCGTTGGGACGGCGGGTGCCTGGAGGGCAGCTCTGGGCTCAGC
 881 GGGCAGTGCTTAGAGCACAGGCCCCTCTGTTGGGGGATGGGGAGGAGAGCAGTCTGCCCTTGGGAGCGTAGGCCCCAGGG
 961 AGACTTCTAAAGCCCCCCCTGTCGTCTGCTCTTCACCCAGCACCACAGAGGCACCTGCTGCACACACAAGCATCTCACTC
1041 GGCCCACGGAGGGGGCCAGGCTTCCTTTGCCTGAAGCTGTTTTGGGAAGGGTCTCCACACAGGCACTGATCTCCCAAGCT
1121 TTTGTCATGATGTCTTTTACCATTTGATAATTTTAAACATTGTTTTTAAACCCAAAACATTTAGTGGTCCGTTGCCTCTG
1201 AAGATGTAAACAAACAAATACACTATTTCTGGGAACATTTATATTGAGATTCTTTGTGGCTATTGGTGTGTCTCACAGGC
1281 AAAATTTGATTTGGCTAAAATAGGCTCAGATGTATTTGTGTGCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
1361 TGTATGAGAGAGAGAGAGACTTTGACGGTTGTAGATATTTTTTCCGCTTTGCCTACTTTATGTTGTATAATCATGTGTTT
1441 ACTAACAAGTTGATGACATGGATGTATTCATAAGACCATGTAATATTGATGTGATTGTTGTCGCTTGAGAAAAAAAGGCA
1521 ACAGCTGATTCTTTCAACAACTGTCACAGAATGGCTGGGCTGAGAACGCTGCCCAGGGCCCTGCAGCTGGCGGGAGAGGT
1601 GTCTGGTGGGAGCGGTGTCTGGTGCGTCAGCCTGCTGCTTCGTGTCTCACTCGAGAGTTGCTTCTGGTTTCACACTTTTT
1681 AACCCCTCTGTGCTTTAGCAGCCGTGACCTTGCCTTCATTGCTTCATCCAGTGCAGGCCTGGGTTATTGAAGACACCAAA
1761 GTGTTTCTCTTCCAGTTTGAAAACCAGGCAGGTTTACACGTGGGTTTCAGTGTATTTGCCTTTGAACCCTTCAAACTAAA
1841 CTTTAGCCTTTTGGCTGGTGTTGAATGTCTTTAGCTGGGGTGACCTGGAGTGACCTGGGACGGTGTTGTGGTTTACCGTC
1921 TCCAGCTTCAGCCTTTCCAGAAACCCTTGTGGAGGGCAGTGTTGGCTGCAGGTTTCATCATATTGCAGTTTGAGGTCACC
2001 ACTATTTGGGGAACAAGCTTGCGTCCTGCTGAGGGGCAGGATTTTCAGCAGAGCGTCGGTGGGGCTGGGCCGTCGTGGAG
2081 GTGGCCCCAGGAGTCATATGGCCATACTCAGACACACCTTGTGTGGCCTGCTCAGAGCTGGATGCCACCTTTAGGCAATG
2161 TTTAGAGTCTATTTTCTAAAGTTTTAAGTATTTTAAGAGGTATTGAGACTAATGAATATAATAGTTCAGTAATTTAAATG
2241 CTTATTTATTTTCAGTGGAAGGATTTTTATTAAAAAGAAGCTAATTGACATGGAAATGTCAGTGAAATTTCTTACCTGCA
2321 AGGAAAGTGAACATTTTGTATTTAAGTAAACTATAATGTGCACATTTTAATAAAGAAATCTGACATTTGAAAAAAAAAAA
2401 AAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gugcagucacugacGCGGGGGa 5'
                        ||||||| 
Target 5' ccccgctccccccaCGCCCCCt 3'
 457 - 478 140.00 -18.10
2 
miRNA  3' gugcagucacUGACGCGGGGga 5'
                    ||| ||||||  
Target 5' cgtttcctccACTCCGCCCCat 3'
 347 - 368 132.00 -16.80
3 
miRNA  3' gugcaGUCACUGACGCGGGGGa 5'
               || |  |  |||:||| 
Target 5' cccccCACTCCCCTCGCTCCCc 3'
 431 - 452 129.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26677950 16 COSMIC
COSN26991231 23 COSMIC
COSN30127699 25 COSMIC
COSN30713016 26 COSMIC
COSN30499404 47 COSMIC
COSN31535858 54 COSMIC
COSN31577932 57 COSMIC
COSN28867479 79 COSMIC
COSN31565051 92 COSMIC
COSN6382079 94 COSMIC
COSN20106733 157 COSMIC
COSN30157811 234 COSMIC
COSN22991026 290 COSMIC
COSN25840641 757 COSMIC
COSN20106727 1326 COSMIC
COSN32057848 1501 COSMIC
COSN29122558 1595 COSMIC
COSN29122312 1611 COSMIC
COSN29759539 1783 COSMIC
COSN31543720 2262 COSMIC
rs7024579 161 GWAS
rs3780190 1501 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755118389 1 dbSNP
rs749513367 3 dbSNP
rs1359148278 4 dbSNP
rs780378263 5 dbSNP
rs377326588 6 dbSNP
rs1384012404 7 dbSNP
rs757710897 9 dbSNP
rs752073484 11 dbSNP
rs763527879 18 dbSNP
rs762508042 21 dbSNP
rs775103013 22 dbSNP
rs764981586 23 dbSNP
rs759144289 25 dbSNP
rs776440180 26 dbSNP
rs1289186874 27 dbSNP
rs770648311 29 dbSNP
rs1448001356 31 dbSNP
rs372636667 33 dbSNP
rs773354897 37 dbSNP
rs768839750 38 dbSNP
rs749425323 43 dbSNP
rs200926560 47 dbSNP
rs756316563 48 dbSNP
rs564809992 50 dbSNP
rs867297288 53 dbSNP
rs1212360660 54 dbSNP
rs11550932 55 dbSNP
rs956992052 60 dbSNP
rs1386193258 61 dbSNP
rs953406127 73 dbSNP
rs998813310 81 dbSNP
rs967281562 82 dbSNP
rs778792745 84 dbSNP
rs1218332955 86 dbSNP
rs1337983676 99 dbSNP
rs114215077 100 dbSNP
rs77543658 101 dbSNP
rs1263803953 103 dbSNP
rs962127454 104 dbSNP
rs540735675 106 dbSNP
rs1463836456 111 dbSNP
rs113182027 116 dbSNP
rs529005776 118 dbSNP
rs1004017179 119 dbSNP
rs76160473 121 dbSNP
rs1424071633 126 dbSNP
rs1048310758 127 dbSNP
rs1002245019 132 dbSNP
rs1400855103 138 dbSNP
rs904849250 140 dbSNP
rs1366231302 147 dbSNP
rs1476707414 150 dbSNP
rs1456935328 157 dbSNP
rs1046136515 158 dbSNP
rs1159822197 159 dbSNP
rs111392257 160 dbSNP
rs1455570734 160 dbSNP
rs1319685463 161 dbSNP
rs7024579 161 dbSNP
rs901407296 162 dbSNP
rs768246075 168 dbSNP
rs1473222073 174 dbSNP
rs1236992416 175 dbSNP
rs551096519 184 dbSNP
rs867851735 185 dbSNP
rs1327783212 188 dbSNP
rs1459530445 189 dbSNP
rs1264197184 196 dbSNP
rs185050758 198 dbSNP
rs557679703 200 dbSNP
rs73668090 204 dbSNP
rs572072240 205 dbSNP
rs1182353764 208 dbSNP
rs1316413099 211 dbSNP
rs554156122 218 dbSNP
rs535552704 219 dbSNP
rs1359557251 224 dbSNP
rs139689868 235 dbSNP
rs1301329392 238 dbSNP
rs1401841046 242 dbSNP
rs1292647581 256 dbSNP
rs953789971 265 dbSNP
rs1290337452 266 dbSNP
rs1348684621 270 dbSNP
rs1228346920 271 dbSNP
rs923270399 274 dbSNP
rs1284445374 280 dbSNP
rs976086113 280 dbSNP
rs1281925018 284 dbSNP
rs962076023 286 dbSNP
rs1231453699 288 dbSNP
rs1255763751 292 dbSNP
rs1482745619 301 dbSNP
rs1448341765 304 dbSNP
rs767952418 307 dbSNP
rs1377624581 309 dbSNP
rs1024204578 313 dbSNP
rs993084848 318 dbSNP
rs1014981582 319 dbSNP
rs1330561872 325 dbSNP
rs958533297 326 dbSNP
rs73668089 331 dbSNP
rs1173778002 333 dbSNP
rs1376825981 334 dbSNP
rs1005624996 335 dbSNP
rs538487130 336 dbSNP
rs952585160 337 dbSNP
rs1368830711 339 dbSNP
rs571058811 342 dbSNP
rs1027267436 346 dbSNP
rs888515079 347 dbSNP
rs1002124914 348 dbSNP
rs1385560381 348 dbSNP
rs994105254 351 dbSNP
rs1343251198 353 dbSNP
rs901434173 356 dbSNP
rs905131876 358 dbSNP
rs1046083183 361 dbSNP
rs377010198 362 dbSNP
rs1013270079 363 dbSNP
rs867778864 369 dbSNP
rs1441595758 370 dbSNP
rs942864727 372 dbSNP
rs1052185482 379 dbSNP
rs1449808499 380 dbSNP
rs552862458 388 dbSNP
rs754265649 388 dbSNP
rs936798758 397 dbSNP
rs1239361163 400 dbSNP
rs890000511 403 dbSNP
rs1178600466 404 dbSNP
rs865797794 404 dbSNP
rs1479915545 408 dbSNP
rs1293412344 409 dbSNP
rs1053951312 412 dbSNP
rs528007785 414 dbSNP
rs565513362 415 dbSNP
rs1219322787 416 dbSNP
rs1033667421 417 dbSNP
rs1272403221 417 dbSNP
rs1465196891 417 dbSNP
rs1320809909 418 dbSNP
rs370413246 419 dbSNP
rs1241741353 421 dbSNP
rs1353839911 422 dbSNP
rs1307838033 424 dbSNP
rs1243805871 425 dbSNP
rs1444494840 427 dbSNP
rs1308866799 429 dbSNP
rs1336070136 429 dbSNP
rs1403608020 431 dbSNP
rs1407994432 431 dbSNP
rs1369560816 432 dbSNP
rs1349765516 433 dbSNP
rs111596624 434 dbSNP
rs71384066 435 dbSNP
rs1293965129 436 dbSNP
rs182381737 437 dbSNP
rs199884017 437 dbSNP
rs577411505 437 dbSNP
rs1423468473 439 dbSNP
rs1242111615 440 dbSNP
rs1435480611 441 dbSNP
rs1411019058 442 dbSNP
rs1349566426 444 dbSNP
rs1161869744 445 dbSNP
rs1421708939 446 dbSNP
rs1335168807 447 dbSNP
rs1166770839 450 dbSNP
rs1381023295 452 dbSNP
rs1437067203 454 dbSNP
rs1276447029 456 dbSNP
rs1342554089 457 dbSNP
rs1418529872 458 dbSNP
rs1158060086 460 dbSNP
rs1417855003 461 dbSNP
rs945706044 461 dbSNP
rs1270085530 464 dbSNP
rs1452738749 465 dbSNP
rs1270162950 466 dbSNP
rs1201622621 468 dbSNP
rs1172637920 470 dbSNP
rs1245372418 470 dbSNP
rs1454054144 470 dbSNP
rs904009985 471 dbSNP
rs1165690699 472 dbSNP
rs1395115957 474 dbSNP
rs116634798 476 dbSNP
rs932241746 478 dbSNP
rs1218370633 480 dbSNP
rs192942436 486 dbSNP
rs1439819647 493 dbSNP
rs1298048541 499 dbSNP
rs958862830 500 dbSNP
rs761557365 507 dbSNP
rs940699386 509 dbSNP
rs561865668 510 dbSNP
rs1468415399 513 dbSNP
rs13340651 514 dbSNP
rs952267382 516 dbSNP
rs994136290 516 dbSNP
rs965366887 517 dbSNP
rs1472802616 519 dbSNP
rs1164947123 525 dbSNP
rs531360040 529 dbSNP
rs528142276 530 dbSNP
rs1321028029 532 dbSNP
rs1390540750 534 dbSNP
rs774920033 535 dbSNP
rs981041136 535 dbSNP
rs187868457 536 dbSNP
rs1361333278 537 dbSNP
rs1024915018 541 dbSNP
rs1053982313 542 dbSNP
rs1001012979 543 dbSNP
rs1177469601 547 dbSNP
rs1433066801 550 dbSNP
rs1270443185 552 dbSNP
rs1463793367 554 dbSNP
rs751968227 555 dbSNP
rs904288502 558 dbSNP
rs1041455913 560 dbSNP
rs1013217988 564 dbSNP
rs1189104868 568 dbSNP
rs1196218541 580 dbSNP
rs549886050 582 dbSNP
rs201625930 589 dbSNP
rs892143088 589 dbSNP
rs1057186914 601 dbSNP
rs937295271 616 dbSNP
rs35248253 623 dbSNP
rs1397972701 624 dbSNP
rs1311189730 625 dbSNP
rs1030705703 634 dbSNP
rs1256031528 635 dbSNP
rs1000615372 638 dbSNP
rs903622149 639 dbSNP
rs909515540 643 dbSNP
rs1256951120 645 dbSNP
rs545663940 646 dbSNP
rs1254812272 647 dbSNP
rs3811126 647 dbSNP
rs373416659 648 dbSNP
rs1182825274 649 dbSNP
rs763242767 649 dbSNP
rs954338467 651 dbSNP
rs1158153946 652 dbSNP
rs1377965802 653 dbSNP
rs1032568935 655 dbSNP
rs529180974 656 dbSNP
rs1303446404 657 dbSNP
rs1465986058 658 dbSNP
rs1371895032 672 dbSNP
rs1391293556 673 dbSNP
rs542246878 673 dbSNP
rs1302473945 678 dbSNP
rs1314263551 681 dbSNP
rs563637285 700 dbSNP
rs1235004187 702 dbSNP
rs907878892 706 dbSNP
rs1346680771 708 dbSNP
rs985220803 709 dbSNP
rs1478340840 715 dbSNP
rs1205331422 725 dbSNP
rs1042578128 726 dbSNP
rs1253303492 726 dbSNP
rs1176500650 730 dbSNP
rs1267829676 739 dbSNP
rs1010015023 740 dbSNP
rs930732206 744 dbSNP
rs1394768496 745 dbSNP
rs895535155 760 dbSNP
rs770566095 762 dbSNP
rs1352818933 764 dbSNP
rs1461943868 766 dbSNP
rs1256258015 776 dbSNP
rs574833273 777 dbSNP
rs969211581 778 dbSNP
rs115440004 789 dbSNP
rs376182094 790 dbSNP
rs538350622 798 dbSNP
rs1048259258 802 dbSNP
rs1274525352 804 dbSNP
rs1305214256 804 dbSNP
rs931227508 804 dbSNP
rs1203738683 813 dbSNP
rs1489415470 816 dbSNP
rs374867490 816 dbSNP
rs972966297 820 dbSNP
rs571024528 823 dbSNP
rs1199087163 826 dbSNP
rs1190704925 834 dbSNP
rs1317035590 836 dbSNP
rs1427930542 837 dbSNP
rs1165550827 838 dbSNP
rs992066830 839 dbSNP
rs956645075 840 dbSNP
rs1389777878 841 dbSNP
rs1435401643 845 dbSNP
rs567463603 847 dbSNP
rs1213540064 848 dbSNP
rs985493689 848 dbSNP
rs953995768 850 dbSNP
rs1231358774 851 dbSNP
rs1272346068 853 dbSNP
rs1032599827 863 dbSNP
rs559217112 873 dbSNP
rs979722215 876 dbSNP
rs771433094 880 dbSNP
rs769358948 881 dbSNP
rs1182555885 889 dbSNP
rs1029163567 895 dbSNP
rs1035813521 899 dbSNP
rs996267779 904 dbSNP
rs1164781856 905 dbSNP
rs1413165654 909 dbSNP
rs1459101497 912 dbSNP
rs1001211394 913 dbSNP
rs878950954 915 dbSNP
rs902013388 916 dbSNP
rs537966575 924 dbSNP
rs1302973211 945 dbSNP
rs150643832 946 dbSNP
rs112262550 947 dbSNP
rs897059949 948 dbSNP
rs1036886211 954 dbSNP
rs1329624293 957 dbSNP
rs943840318 965 dbSNP
rs3811127 974 dbSNP
rs932722133 977 dbSNP
rs1049027506 978 dbSNP
rs369591468 979 dbSNP
rs1407690268 980 dbSNP
rs1491146841 980 dbSNP
rs927360991 980 dbSNP
rs1311735636 981 dbSNP
rs770101610 981 dbSNP
rs966967803 981 dbSNP
rs1044881806 983 dbSNP
rs776370190 984 dbSNP
rs1021593757 988 dbSNP
rs917751713 991 dbSNP
rs1372290088 995 dbSNP
rs992344198 996 dbSNP
rs961120989 1004 dbSNP
rs1345974797 1005 dbSNP
rs1033849180 1010 dbSNP
rs778928309 1011 dbSNP
rs1440106216 1013 dbSNP
rs956594888 1024 dbSNP
rs1001273272 1026 dbSNP
rs1478524368 1027 dbSNP
rs768586468 1037 dbSNP
rs567969594 1040 dbSNP
rs1026632463 1041 dbSNP
rs1172525578 1047 dbSNP
rs1211413563 1048 dbSNP
rs995111295 1052 dbSNP
rs897090971 1054 dbSNP
rs1358811906 1060 dbSNP
rs1436992937 1064 dbSNP
rs979083303 1068 dbSNP
rs1369138125 1069 dbSNP
rs11787786 1073 dbSNP
rs1233824673 1074 dbSNP
rs11787785 1076 dbSNP
rs968129095 1077 dbSNP
rs1245388663 1086 dbSNP
rs1028693715 1095 dbSNP
rs79321298 1103 dbSNP
rs890994023 1108 dbSNP
rs1448184250 1113 dbSNP
rs1452205365 1115 dbSNP
rs10117333 1123 dbSNP
rs1373183162 1138 dbSNP
rs1019058688 1161 dbSNP
rs182453955 1162 dbSNP
rs1005019903 1172 dbSNP
rs551984405 1181 dbSNP
rs1405878727 1185 dbSNP
rs1327738862 1190 dbSNP
rs190622150 1191 dbSNP
rs1043757732 1195 dbSNP
rs1391061117 1207 dbSNP
rs1321416722 1219 dbSNP
rs1440448751 1219 dbSNP
rs1225394858 1223 dbSNP
rs1269635459 1229 dbSNP
rs1357752565 1231 dbSNP
rs373948263 1233 dbSNP
rs560443026 1246 dbSNP
rs1271668154 1249 dbSNP
rs541552931 1252 dbSNP
rs1262054869 1262 dbSNP
rs146353611 1274 dbSNP
rs1044452694 1275 dbSNP
rs1158656402 1279 dbSNP
rs1371986367 1292 dbSNP
rs914160809 1293 dbSNP
rs1469626028 1294 dbSNP
rs992859102 1298 dbSNP
rs1415433149 1300 dbSNP
rs1460682440 1305 dbSNP
rs185820544 1307 dbSNP
rs1387461754 1308 dbSNP
rs1200798120 1309 dbSNP
rs1451936885 1319 dbSNP
rs1266361671 1320 dbSNP
rs1291926808 1323 dbSNP
rs769912727 1323 dbSNP
rs1222052591 1324 dbSNP
rs1489904366 1325 dbSNP
rs1288256116 1326 dbSNP
rs1240956797 1327 dbSNP
rs1202941248 1328 dbSNP
rs926812079 1330 dbSNP
rs1350657295 1331 dbSNP
rs1190005975 1332 dbSNP
rs980887769 1335 dbSNP
rs796873088 1336 dbSNP
rs1365306641 1339 dbSNP
rs1451906251 1342 dbSNP
rs1158174228 1346 dbSNP
rs1026663565 1348 dbSNP
rs995142391 1349 dbSNP
rs1332069887 1350 dbSNP
rs1302867002 1352 dbSNP
rs1311112154 1352 dbSNP
rs1392466623 1356 dbSNP
rs961296487 1358 dbSNP
rs1334279944 1360 dbSNP
rs1236465870 1361 dbSNP
rs1259730722 1362 dbSNP
rs1402727877 1362 dbSNP
rs1348124600 1363 dbSNP
rs1177651164 1364 dbSNP
rs1180799052 1364 dbSNP
rs1191070854 1364 dbSNP
rs1212446218 1364 dbSNP
rs1252449182 1364 dbSNP
rs1277561887 1364 dbSNP
rs1384833289 1364 dbSNP
rs1395965527 1364 dbSNP
rs1417035352 1364 dbSNP
rs1436813957 1364 dbSNP
rs146198713 1364 dbSNP
rs1485334692 1364 dbSNP
rs58474709 1364 dbSNP
rs58556591 1364 dbSNP
rs60517775 1364 dbSNP
rs752950358 1364 dbSNP
rs764282308 1364 dbSNP
rs781085376 1364 dbSNP
rs867356310 1364 dbSNP
rs1195082192 1365 dbSNP
rs1362061359 1366 dbSNP
rs1191909636 1367 dbSNP
rs1327058384 1367 dbSNP
rs1397061852 1367 dbSNP
rs759673349 1367 dbSNP
rs770605546 1367 dbSNP
rs1323424233 1368 dbSNP
rs1442694233 1368 dbSNP
rs1015259848 1369 dbSNP
rs1214691237 1369 dbSNP
rs1298343027 1369 dbSNP
rs1305755934 1369 dbSNP
rs1366444082 1369 dbSNP
rs1217875330 1370 dbSNP
rs1399594338 1370 dbSNP
rs1008597576 1371 dbSNP
rs1469616174 1371 dbSNP
rs1405754250 1372 dbSNP
rs1174278554 1377 dbSNP
rs1188423361 1380 dbSNP
rs1252660192 1380 dbSNP
rs796300546 1380 dbSNP
rs1417443104 1384 dbSNP
rs1478288045 1384 dbSNP
rs183438369 1386 dbSNP
rs1196934754 1387 dbSNP
rs1479616570 1391 dbSNP
rs1420507672 1393 dbSNP
rs1164624997 1398 dbSNP
rs1460255879 1398 dbSNP
rs1349014181 1401 dbSNP
rs142130253 1405 dbSNP
rs1049606339 1406 dbSNP
rs36187019 1406 dbSNP
rs1446468065 1407 dbSNP
rs1282189628 1408 dbSNP
rs996651794 1409 dbSNP
rs1399359597 1411 dbSNP
rs1202724986 1413 dbSNP
rs1346250383 1414 dbSNP
rs1283123961 1419 dbSNP
rs1231269532 1422 dbSNP
rs1288870706 1424 dbSNP
rs555488467 1432 dbSNP
rs903943812 1442 dbSNP
rs1240430745 1446 dbSNP
rs148384572 1447 dbSNP
rs945440998 1455 dbSNP
rs1278404393 1461 dbSNP
rs559180143 1462 dbSNP
rs534446039 1463 dbSNP
rs1056454439 1470 dbSNP
rs1335550707 1478 dbSNP
rs1409102297 1484 dbSNP
rs1400935482 1491 dbSNP
rs1160792952 1493 dbSNP
rs3780190 1501 dbSNP
rs763375055 1502 dbSNP
rs980918805 1503 dbSNP
rs952180412 1510 dbSNP
rs1412839424 1531 dbSNP
rs1426094122 1541 dbSNP
rs1225712174 1542 dbSNP
rs919682661 1542 dbSNP
rs1475178265 1548 dbSNP
rs1240437683 1567 dbSNP
rs1282550121 1568 dbSNP
rs973835546 1569 dbSNP
rs1209950079 1582 dbSNP
rs1462202807 1586 dbSNP
rs1015706829 1591 dbSNP
rs555201228 1592 dbSNP
rs1438688384 1602 dbSNP
rs143392932 1613 dbSNP
rs1028208281 1614 dbSNP
rs1333380330 1622 dbSNP
rs1202216679 1625 dbSNP
rs149043177 1626 dbSNP
rs113189561 1632 dbSNP
rs1213642903 1641 dbSNP
rs191792181 1642 dbSNP
rs1010093906 1652 dbSNP
rs1200409797 1653 dbSNP
rs892532237 1654 dbSNP
rs1448105069 1657 dbSNP
rs1237939149 1660 dbSNP
rs1056887385 1664 dbSNP
rs1382005988 1667 dbSNP
rs1193801277 1668 dbSNP
rs939339361 1674 dbSNP
rs1476725674 1675 dbSNP
rs905461228 1685 dbSNP
rs570249580 1696 dbSNP
rs1420224548 1703 dbSNP
rs1411582763 1704 dbSNP
rs867013441 1709 dbSNP
rs1467079652 1712 dbSNP
rs1400788752 1715 dbSNP
rs930896334 1728 dbSNP
rs1369018735 1730 dbSNP
rs1232674862 1733 dbSNP
rs1169407568 1734 dbSNP
rs1270841690 1737 dbSNP
rs1409677655 1738 dbSNP
rs1342155476 1746 dbSNP
rs1213262643 1756 dbSNP
rs920798976 1764 dbSNP
rs1335857983 1767 dbSNP
rs760396644 1767 dbSNP
rs186129000 1784 dbSNP
rs972194903 1792 dbSNP
rs939790949 1798 dbSNP
rs908255744 1800 dbSNP
rs1242136020 1804 dbSNP
rs1445282280 1814 dbSNP
rs1168399975 1817 dbSNP
rs1242568800 1828 dbSNP
rs1182315562 1829 dbSNP
rs1461812980 1841 dbSNP
rs7035340 1843 dbSNP
rs778977734 1858 dbSNP
rs1392637657 1868 dbSNP
rs1233821663 1881 dbSNP
rs867982059 1882 dbSNP
rs1386411995 1884 dbSNP
rs1319080767 1889 dbSNP
rs955026717 1893 dbSNP
rs1027987613 1896 dbSNP
rs975361142 1900 dbSNP
rs767060290 1901 dbSNP
rs1022160159 1902 dbSNP
rs1291550388 1912 dbSNP
rs1353841011 1917 dbSNP
rs560098439 1918 dbSNP
rs117188618 1929 dbSNP
rs1358142020 1933 dbSNP
rs1448174894 1938 dbSNP
rs529966891 1939 dbSNP
rs78850946 1945 dbSNP
rs1262434844 1959 dbSNP
rs1035078355 1962 dbSNP
rs1003957106 1966 dbSNP
rs544652700 1970 dbSNP
rs1448918356 1972 dbSNP
rs1159320982 1973 dbSNP
rs1377553227 1983 dbSNP
rs905243828 1986 dbSNP
rs1417990400 1999 dbSNP
rs1297657863 2000 dbSNP
rs1356724225 2001 dbSNP
rs1045039956 2004 dbSNP
rs930927228 2005 dbSNP
rs577407609 2009 dbSNP
rs1340206519 2017 dbSNP
rs1243640118 2021 dbSNP
rs1352356807 2022 dbSNP
rs371680064 2023 dbSNP
rs1036948983 2037 dbSNP
rs940834166 2039 dbSNP
rs1212851676 2054 dbSNP
rs1425483281 2055 dbSNP
rs1384703245 2057 dbSNP
rs1161679979 2058 dbSNP
rs150748312 2060 dbSNP
rs180746948 2064 dbSNP
rs1438053679 2065 dbSNP
rs1177038423 2071 dbSNP
rs1479844314 2072 dbSNP
rs933727060 2074 dbSNP
rs191519112 2075 dbSNP
rs1222792699 2084 dbSNP
rs1490067092 2086 dbSNP
rs920959786 2093 dbSNP
rs1288962073 2103 dbSNP
rs73558598 2104 dbSNP
rs1317501078 2106 dbSNP
rs967974665 2109 dbSNP
rs1307903180 2110 dbSNP
rs1221968035 2111 dbSNP
rs1369491986 2117 dbSNP
rs111691397 2135 dbSNP
rs1482866811 2140 dbSNP
rs988388643 2147 dbSNP
rs79386258 2161 dbSNP
rs1456617447 2167 dbSNP
rs1365181817 2168 dbSNP
rs1462051188 2171 dbSNP
rs1421567997 2186 dbSNP
rs1174007396 2188 dbSNP
rs1377624198 2189 dbSNP
rs118041735 2191 dbSNP
rs1206625093 2194 dbSNP
rs1300278282 2199 dbSNP
rs1398472882 2200 dbSNP
rs1444163078 2201 dbSNP
rs1330206214 2221 dbSNP
rs1371243720 2222 dbSNP
rs555727831 2238 dbSNP
rs1159052895 2248 dbSNP
rs1003666966 2253 dbSNP
rs905276402 2275 dbSNP
rs755088158 2281 dbSNP
rs1227986060 2282 dbSNP
rs1417796114 2285 dbSNP
rs1023616387 2289 dbSNP
rs1427710759 2291 dbSNP
rs1046825 2311 dbSNP
rs994776213 2321 dbSNP
rs1479941467 2340 dbSNP
rs1253911329 2350 dbSNP
rs1469990441 2353 dbSNP
rs3780189 2358 dbSNP
rs570115617 2360 dbSNP
rs775405700 2362 dbSNP
rs1485928845 2370 dbSNP
rs1421957341 2379 dbSNP
rs769430067 2379 dbSNP
rs1259581238 2380 dbSNP
rs890661801 2384 dbSNP
rs917365801 2393 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gugcagucacuGACGCGGGGGa 5'
                     || |||:||| 
Target 5' ------cucccCU-CGCUCCCc 3'
 		1 - 15
2 
miRNA  3' gugcagucacugacGCGGGGGA------- 5'
                        |||:|||        
Target 5' gcucccccucccccCGCUCCCCCCACGCC 3'
 		9 - 37
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177614. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_4 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177626. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_4 PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_181701 | 3UTR | CCUGCUCCAGGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000358701.5 | 3UTR | CUCCCCUCGCUCCCCCUCCCCCCGCUCCCCCCACGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000358701.5 | 3UTR | CUCCCCUCGCUCCCCCUCCCCCCGCUCCCCCCACGCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000358701.5 | 3UTR | CACUCCCCUCGCUCCCCCUCCCCCCGCUCCCCCCACGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4697-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT441332 C19orf26 CACN beta subunit associated regulatory protein 2 4
MIRT451390 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT452310 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT455043 MEN1 menin 1 2 2
MIRT455256 DDX39B DExD-box helicase 39B 2 10
MIRT461279 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464945 TXLNA taxilin alpha 2 4
MIRT468043 SIK1 salt inducible kinase 1 2 2
MIRT472523 NACC1 nucleus accumbens associated 1 2 2
MIRT472929 MSN moesin 2 2
MIRT473247 MIDN midnolin 2 2
MIRT475828 HDGF heparin binding growth factor 2 2
MIRT478744 CS citrate synthase 2 2
MIRT480081 CALR calreticulin 2 2
MIRT483482 STMN3 stathmin 3 2 4
MIRT483643 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT483721 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484539 BARHL1 BarH like homeobox 1 2 6
MIRT486041 WSCD1 WSC domain containing 1 2 4
MIRT486142 SIX5 SIX homeobox 5 2 6
MIRT486498 MYH11 myosin heavy chain 11 2 2
MIRT486977 STEAP3 STEAP3 metalloreductase 2 4
MIRT487279 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 4
MIRT487742 MIB2 mindbomb E3 ubiquitin protein ligase 2 2 2
MIRT487987 RXRB retinoid X receptor beta 2 2
MIRT488338 PAX2 paired box 2 2 2
MIRT488668 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT488752 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT488812 TBC1D28 TBC1 domain family member 28 2 2
MIRT489380 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489744 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT489960 GNB2 G protein subunit beta 2 2 2
MIRT490418 VPS51 VPS51, GARP complex subunit 2 4
MIRT490639 FEM1A fem-1 homolog A 2 2
MIRT491086 MSI1 musashi RNA binding protein 1 2 4
MIRT491298 VGF VGF nerve growth factor inducible 2 4
MIRT491366 SLC12A5 solute carrier family 12 member 5 2 2
MIRT492464 RASD1 ras related dexamethasone induced 1 2 4
MIRT492872 NFIX nuclear factor I X 2 2
MIRT492951 NEUROD2 neuronal differentiation 2 2 2
MIRT493704 H2AFX H2A histone family member X 2 2
MIRT493977 EIF1 eukaryotic translation initiation factor 1 2 4
MIRT500360 ZNF385A zinc finger protein 385A 2 2
MIRT501154 SLC10A7 solute carrier family 10 member 7 2 6
MIRT509625 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT512232 ATG2A autophagy related 2A 2 8
MIRT529822 ARGFX arginine-fifty homeobox 2 4
MIRT531179 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT538971 BCL7A BCL tumor suppressor 7A 2 2
MIRT548357 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT553634 TJAP1 tight junction associated protein 1 2 2
MIRT558050 EVI5L ecotropic viral integration site 5 like 2 2
MIRT562548 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT568941 RUNX3 runt related transcription factor 3 2 2
MIRT569114 ONECUT3 one cut homeobox 3 2 2
MIRT573591 CERS1 ceramide synthase 1 2 2
MIRT619317 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT621202 ARPC1B actin related protein 2/3 complex subunit 1B 2 2
MIRT628844 FAM151B family with sequence similarity 151 member B 2 2
MIRT670497 LYRM4 LYR motif containing 4 2 2
MIRT670545 SHISA2 shisa family member 2 2 2
MIRT671026 PCDHB2 protocadherin beta 2 2 2
MIRT688989 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT709275 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT715084 ELOF1 elongation factor 1 homolog 2 2
MIRT718348 NPBWR1 neuropeptides B and W receptor 1 2 2
MIRT737406 MMP7 matrix metallopeptidase 7 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4697 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4697-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4697-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (Bads-200, Bats-72, BCap37)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-4697-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4697-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4697-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4697-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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