pre-miRNA Information
pre-miRNA hsa-mir-509-1   
Genomic Coordinates chrX: 147260532 - 147260625
Description Homo sapiens miR-509-1 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies includes a 1 nt extension at the 3' end (A), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-509-2   
Genomic Coordinates chrX: 147258760 - 147258850
Description Homo sapiens miR-509-2 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies includes a 1 nt extension at the 3' end (A), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-509-3   
Genomic Coordinates chrX: 147259652 - 147259726
Description Homo sapiens miR-509-3 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-509-3p
Sequence 55| UGAUUGGUACGUCUGUGGGUAG |76
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs782045310 5 dbSNP
rs782582906 5 dbSNP
rs201952682 10 dbSNP
rs372437549 10 dbSNP
rs781816035 10 dbSNP
rs782690043 11 dbSNP
rs782219815 11 dbSNP
rs782709356 11 dbSNP
rs911953291 12 dbSNP
rs782157585 13 dbSNP
rs782561068 17 dbSNP
rs782154164 19 dbSNP
rs1319750096 19 dbSNP
rs200517501 20 dbSNP
rs781912517 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RAD51D   
Synonyms BROVCA4, R51H3, RAD51L3, TRAD
Description RAD51 paralog D
Transcript NM_001142571   
Other Transcripts NM_002878 , NM_133629   
Expression
Putative miRNA Targets on RAD51D
3'UTR of RAD51D
(miRNA target sites are highlighted)
>RAD51D|NM_001142571|3'UTR
   1 CCTGTGCTGTTGTTTGGGAAACAGGGAAGCATTGGGGACCCCTCCCAACTTTTCTTCCCAGTAACGCCTGCTGTTTACTG
  81 CCACCTGGCACTGGTGACTACAGACGTTCTCAGGCTGGCCAGAAGAGACATCTTGGGTTCCTTGGCCTCACTCTCTGTAA
 161 GCATATAAACCACAGGCGAAAGAGGATGCTGCATTGCGAGGACCCAGAAATTCATACTGGTGCCACGTTTCCTTCCCTTA
 241 TTTCTAACGTGTATGTTTCTGGTGGAAACCAAGTTCACCCTGGCTGGGAGCATCTCTGATGAGGCATGCTGGCGACTGGA
 321 TGGATAATCCTGTGCATCACCATTGTGTCCTGTGCTCCCTCCTAGCGCAGTGGCCAAGCCGGGAAAGCCTCTAACTTGCC
 401 TTTGCTGCTGCTGCCTTTTTTTTCTTTTGTCTCTGCCTTTCCATTTGTTAGATGGGGGCCCACTCTTCCTTAGCTCTGTC
 481 TCTGAGTTACTGGGTGGAAATAAGCTTATAAATGAAATACTCTTCTTCATCTCTGTTTTGCTCTTAAAAATATAAAAAGG
 561 CAATTCCCCGAGCCCTAGAGCCACCTGATTTCCCCTTAGAAGGCTGTTTTTCAGTTTCCCCCAGTGAGGCCCAAAGAACA
 641 GTTTATTCCTCCTTTCCTCTTGCTGATTTGGTTTCAGACCTGCCTGCATCACCATGACTAGGTGAGAACGTGTGGGCTCG
 721 CTGCAGTTCCAGGGATATAATTTAACAGAAAGGGAGGGTATGACCTGCTCCTGGTGAATCCAGCCACTCATTTAATATGC
 801 ATGGTGCCCTGTGGGGCCCCTCCACAGTACAGCATAACCAGAGGTGCTGAACCATGGCCTTGCCCATAAACAGACAGAGG
 881 AGAATTTGCACAGTAAATAGAGCCAGCTGGGAAAATTGATGCTGACGTAAATAATACATGGCAAATCTAGTCCTTTATGC
 961 AGAAATTCATTGCTGGTGGCTCCAAGATGCAATATAATTACACCTCTCTTCCTGCCAGCTGTACCACAGCTAGTGCCCTA
1041 GTGTATGAAATAATCCCTCTGTCTTTCACCAGCACTGTGGCCATCCGTCTGAGAGCCATGACCCTGGCTGGGAGGGGACG
1121 AAGACACCAGGGAATGGAAAATAAAAGGAAAAGTACAGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauGGGU-GUCUGCAUGGUuagu 5'
             ||:: ||| :||||||    
Target 5' cttCCTGCCAGCTGTACCAcagc 3'
1008 - 1030 107.00 -14.90
2
miRNA  3' gauGGGU-GUCUGCAUGGUUAGu 5'
             ||:| :: |:| | :|||| 
Target 5' tgcCCTAGTGTATGAAATAATCc 3'
1034 - 1056 107.00 -10.90
3
miRNA  3' gauGGGUGUCUGCAUGGUUagu 5'
             |: :::||   |||||   
Target 5' tttCTGGTGGA--AACCAAgtt 3'
256 - 275 103.00 -6.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1171226 4 ClinVar
231210 4 ClinVar
378464 7 ClinVar
630038 10 ClinVar
920223 11 ClinVar
421911 15 ClinVar
926967 16 ClinVar
322615 435 ClinVar
322611 879 ClinVar
986729 1466 ClinVar
COSN26991423 47 COSMIC
COSN30146747 68 COSMIC
COSN30186796 81 COSMIC
COSN31557452 89 COSMIC
COSN31514654 105 COSMIC
COSN28647545 130 COSMIC
COSN31532773 132 COSMIC
COSN16421152 165 COSMIC
COSN21157086 178 COSMIC
COSN1717923 236 COSMIC
COSN7165195 411 COSMIC
COSN6102780 544 COSMIC
COSN22087133 710 COSMIC
COSN23196105 715 COSMIC
COSN6102779 716 COSMIC
COSN14966842 1050 COSMIC
COSN27281789 1219 COSMIC
COSN21146454 1283 COSMIC
COSN16156118 1299 COSMIC
COSN27017091 1791 COSMIC
COSN22505514 1934 COSMIC
COSN4905720 2363 COSMIC
COSN21348010 2484 COSMIC
COSN29896503 2527 COSMIC
COSN6102778 2793 COSMIC
COSN5416048 3257 COSMIC
COSN28340727 3436 COSMIC
COSN28562532 3472 COSMIC
COSN16263125 3482 COSMIC
COSN26131440 3485 COSMIC
COSN16278189 3488 COSMIC
COSN8242040 3514 COSMIC
COSN27188883 3687 COSMIC
COSN16951331 3819 COSMIC
COSN23159625 3863 COSMIC
COSN8242039 4263 COSMIC
COSN8242038 4653 COSMIC
COSN26145079 4666 COSMIC
COSN6102777 5289 COSMIC
COSN5839442 6370 COSMIC
COSN1717922 6560 COSMIC
COSN22977110 6701 COSMIC
COSN22781211 6852 COSMIC
COSN16452601 6956 COSMIC
COSN29455454 7634 COSMIC
COSN8835351 7933 COSMIC
COSN6102776 8292 COSMIC
COSN21940880 8319 COSMIC
COSN27011788 8592 COSMIC
COSN6102775 8725 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs876659026 4 dbSNP
rs370985675 7 dbSNP
rs759502122 10 dbSNP
rs745601646 15 dbSNP
rs374939642 16 dbSNP
rs770908196 24 dbSNP
rs549512215 32 dbSNP
rs778697814 34 dbSNP
rs539150931 39 dbSNP
rs770831162 40 dbSNP
rs1473355636 48 dbSNP
rs1016490032 56 dbSNP
rs1197053407 57 dbSNP
rs1005056480 61 dbSNP
rs1161738692 62 dbSNP
rs1262339493 63 dbSNP
rs768964491 65 dbSNP
rs570462507 66 dbSNP
rs904035145 67 dbSNP
rs780260963 70 dbSNP
rs1328325383 79 dbSNP
rs1223315194 90 dbSNP
rs1371386222 91 dbSNP
rs1317432419 96 dbSNP
rs756212549 100 dbSNP
rs749139316 101 dbSNP
rs781490616 102 dbSNP
rs28363291 105 dbSNP
rs45494001 106 dbSNP
rs189546138 112 dbSNP
rs758021700 113 dbSNP
rs910177281 117 dbSNP
rs752402824 120 dbSNP
rs764800957 121 dbSNP
rs758906405 122 dbSNP
rs1044102377 127 dbSNP
rs28363292 130 dbSNP
rs893059535 132 dbSNP
rs1242272024 133 dbSNP
rs1179932150 136 dbSNP
rs1217701031 137 dbSNP
rs919122737 138 dbSNP
rs773115307 153 dbSNP
rs886052816 154 dbSNP
rs971854763 155 dbSNP
rs1215074439 157 dbSNP
rs772043573 159 dbSNP
rs1294115160 164 dbSNP
rs548862590 165 dbSNP
rs1382357586 170 dbSNP
rs183694951 177 dbSNP
rs575313654 178 dbSNP
rs1243766590 186 dbSNP
rs1363195503 189 dbSNP
rs745882312 197 dbSNP
rs1429318144 198 dbSNP
rs1385062695 211 dbSNP
rs912426745 218 dbSNP
rs1349799055 226 dbSNP
rs1226564985 227 dbSNP
rs1358053171 232 dbSNP
rs1013637849 245 dbSNP
rs757673099 248 dbSNP
rs1209298800 249 dbSNP
rs1289209596 251 dbSNP
rs747563457 253 dbSNP
rs778094856 254 dbSNP
rs180988416 272 dbSNP
rs1430088714 276 dbSNP
rs933457720 277 dbSNP
rs922000726 279 dbSNP
rs1360177677 281 dbSNP
rs753066633 282 dbSNP
rs1185845198 283 dbSNP
rs1487294815 289 dbSNP
rs1271100046 290 dbSNP
rs778373313 299 dbSNP
rs1223359669 300 dbSNP
rs1358931768 304 dbSNP
rs1289875877 306 dbSNP
rs1290952591 311 dbSNP
rs963332664 313 dbSNP
rs1016542699 314 dbSNP
rs904085683 316 dbSNP
rs1213295264 322 dbSNP
rs754682491 331 dbSNP
rs1021172031 332 dbSNP
rs1369795182 337 dbSNP
rs546351920 338 dbSNP
rs780623540 340 dbSNP
rs577243395 342 dbSNP
rs560606097 343 dbSNP
rs950931934 345 dbSNP
rs747638385 347 dbSNP
rs1427172710 351 dbSNP
rs1291425379 357 dbSNP
rs901976329 360 dbSNP
rs1373406918 361 dbSNP
rs1244198349 363 dbSNP
rs1282435775 363 dbSNP
rs12947947 366 dbSNP
rs28363293 367 dbSNP
rs879561914 368 dbSNP
rs28363294 373 dbSNP
rs1200159186 374 dbSNP
rs780660248 380 dbSNP
rs892777147 381 dbSNP
rs1197755972 383 dbSNP
rs761640492 387 dbSNP
rs930587471 409 dbSNP
rs1052705074 414 dbSNP
rs1251070735 418 dbSNP
rs1217210588 419 dbSNP
rs934600489 423 dbSNP
rs891042447 426 dbSNP
rs774305718 429 dbSNP
rs1284489144 431 dbSNP
rs1366141544 433 dbSNP
rs1163876788 435 dbSNP
rs1389148488 435 dbSNP
rs757426326 435 dbSNP
rs971907093 436 dbSNP
rs1344303951 437 dbSNP
rs949895261 443 dbSNP
rs932444361 445 dbSNP
rs1392738686 456 dbSNP
rs1396801627 458 dbSNP
rs1297342399 461 dbSNP
rs1220081229 462 dbSNP
rs28363295 467 dbSNP
rs1408117986 472 dbSNP
rs1177058248 473 dbSNP
rs1480099478 478 dbSNP
rs1375971106 480 dbSNP
rs1361505195 482 dbSNP
rs1184119054 498 dbSNP
rs1337511421 501 dbSNP
rs922044239 507 dbSNP
rs917040808 521 dbSNP
rs1453429909 523 dbSNP
rs1419845544 530 dbSNP
rs370012734 535 dbSNP
rs1250098849 541 dbSNP
rs142021403 555 dbSNP
rs759842518 569 dbSNP
rs1320563612 570 dbSNP
rs1297961642 574 dbSNP
rs1400915860 577 dbSNP
rs1264206851 580 dbSNP
rs1203563495 593 dbSNP
rs959471390 599 dbSNP
rs1245477020 606 dbSNP
rs1462307556 609 dbSNP
rs1345258945 618 dbSNP
rs1253701315 619 dbSNP
rs1240586198 621 dbSNP
rs1335918257 622 dbSNP
rs942023677 624 dbSNP
rs1444205582 626 dbSNP
rs1384702727 639 dbSNP
rs1337198741 640 dbSNP
rs1366770791 648 dbSNP
rs1034119334 661 dbSNP
rs1247066467 661 dbSNP
rs1400010688 681 dbSNP
rs1160317168 682 dbSNP
rs1454380480 686 dbSNP
rs909242124 688 dbSNP
rs1363365432 691 dbSNP
rs1176987047 694 dbSNP
rs200486983 701 dbSNP
rs1446723353 703 dbSNP
rs983433112 709 dbSNP
rs28363296 710 dbSNP
rs928845712 713 dbSNP
rs188627847 715 dbSNP
rs1286969464 719 dbSNP
rs1009781629 720 dbSNP
rs970605862 724 dbSNP
rs1206312498 728 dbSNP
rs1350756279 733 dbSNP
rs1284754644 734 dbSNP
rs902028572 735 dbSNP
rs747510011 738 dbSNP
rs1315419267 746 dbSNP
rs1022725287 748 dbSNP
rs1330930137 753 dbSNP
rs765391295 754 dbSNP
rs1231502466 756 dbSNP
rs1265570521 758 dbSNP
rs1447035275 768 dbSNP
rs1338563096 775 dbSNP
rs1011308801 780 dbSNP
rs1320203318 789 dbSNP
rs1019085862 790 dbSNP
rs765395345 795 dbSNP
rs1187970051 798 dbSNP
rs888855156 799 dbSNP
rs1432430878 800 dbSNP
rs539550426 801 dbSNP
rs1431395201 807 dbSNP
rs1426740648 808 dbSNP
rs778188436 813 dbSNP
rs1163269756 815 dbSNP
rs570477750 816 dbSNP
rs1244256241 818 dbSNP
rs148160294 819 dbSNP
rs533565196 831 dbSNP
rs748462999 839 dbSNP
rs1455404873 842 dbSNP
rs779367890 853 dbSNP
rs1219419379 855 dbSNP
rs1390229121 856 dbSNP
rs891052266 857 dbSNP
rs1213857573 861 dbSNP
rs1490722474 865 dbSNP
rs1292060712 866 dbSNP
rs1227456505 868 dbSNP
rs769874559 873 dbSNP
rs1353976502 874 dbSNP
rs1285512267 877 dbSNP
rs1385487470 877 dbSNP
rs754041004 879 dbSNP
rs1228384647 888 dbSNP
rs568016215 889 dbSNP
rs1287000851 892 dbSNP
rs1314654992 893 dbSNP
rs1339793485 896 dbSNP
rs1217281229 898 dbSNP
rs764072863 900 dbSNP
rs1219976609 902 dbSNP
rs754559169 910 dbSNP
rs1490447705 916 dbSNP
rs1281732476 917 dbSNP
rs1366352084 921 dbSNP
rs753580431 926 dbSNP
rs757525053 927 dbSNP
rs1422061440 929 dbSNP
rs779418858 931 dbSNP
rs1475347059 932 dbSNP
rs143673500 937 dbSNP
rs1190794107 938 dbSNP
rs1481130500 941 dbSNP
rs1390225692 942 dbSNP
rs1269048216 947 dbSNP
rs1220347785 951 dbSNP
rs1393614904 954 dbSNP
rs1449554454 971 dbSNP
rs1456534322 973 dbSNP
rs778118213 975 dbSNP
rs749964031 982 dbSNP
rs1196181441 984 dbSNP
rs1305177164 990 dbSNP
rs532025403 991 dbSNP
rs1276229302 999 dbSNP
rs1366656151 999 dbSNP
rs1409570434 1003 dbSNP
rs1465780084 1004 dbSNP
rs569497853 1008 dbSNP
rs1428189170 1018 dbSNP
rs1346212203 1021 dbSNP
rs1274384536 1022 dbSNP
rs1306769204 1023 dbSNP
rs1376101908 1025 dbSNP
rs577070431 1035 dbSNP
rs11650161 1038 dbSNP
rs1434536359 1040 dbSNP
rs1356520892 1050 dbSNP
rs1307000462 1055 dbSNP
rs1173875753 1056 dbSNP
rs1293483412 1061 dbSNP
rs1359936697 1061 dbSNP
rs1036240302 1062 dbSNP
rs1465440812 1069 dbSNP
rs185060714 1075 dbSNP
rs774128458 1082 dbSNP
rs1481078787 1083 dbSNP
rs148926048 1086 dbSNP
rs560391189 1087 dbSNP
rs1476808223 1089 dbSNP
rs1234267802 1090 dbSNP
rs1182171617 1095 dbSNP
rs1457149188 1096 dbSNP
rs1255977824 1098 dbSNP
rs139187992 1102 dbSNP
rs1436022298 1108 dbSNP
rs1047768091 1117 dbSNP
rs771025661 1119 dbSNP
rs763998135 1120 dbSNP
rs1199386190 1121 dbSNP
rs1429533784 1125 dbSNP
rs1217562844 1127 dbSNP
rs1168723149 1129 dbSNP
rs759664000 1136 dbSNP
rs1280355229 1138 dbSNP
rs1446398420 1140 dbSNP
rs1375119770 1147 dbSNP
rs776977460 1148 dbSNP
rs771144747 1153 dbSNP
rs1461003099 1154 dbSNP
rs1261463279 1155 dbSNP
rs573589168 1157 dbSNP
rs760691280 1161 dbSNP
rs926719928 1164 dbSNP
rs555251476 1169 dbSNP
rs970320422 1172 dbSNP
rs1237428790 1174 dbSNP
rs1316746588 1176 dbSNP
rs1409604604 1178 dbSNP
rs773304898 1181 dbSNP
rs772529166 1182 dbSNP
rs979476734 1186 dbSNP
rs968041419 1199 dbSNP
rs1461670236 1202 dbSNP
rs1205219213 1209 dbSNP
rs533692463 1220 dbSNP
rs1342026675 1223 dbSNP
rs1460077942 1227 dbSNP
rs990273246 1229 dbSNP
rs560937515 1233 dbSNP
rs1313329764 1238 dbSNP
rs1449016092 1242 dbSNP
rs1399288167 1253 dbSNP
rs1185152551 1258 dbSNP
rs1422165729 1272 dbSNP
rs370047559 1273 dbSNP
rs1358602069 1279 dbSNP
rs957155239 1286 dbSNP
rs1031351192 1288 dbSNP
rs1404508526 1289 dbSNP
rs998481881 1293 dbSNP
rs1383090521 1297 dbSNP
rs77977796 1299 dbSNP
rs75291947 1300 dbSNP
rs1433982345 1302 dbSNP
rs1268045140 1304 dbSNP
rs1160408876 1305 dbSNP
rs1363865707 1307 dbSNP
rs375760033 1309 dbSNP
rs541757027 1310 dbSNP
rs1161038089 1313 dbSNP
rs9891230 1315 dbSNP
rs759507908 1317 dbSNP
rs994507581 1318 dbSNP
rs1213997906 1319 dbSNP
rs556013728 1322 dbSNP
rs1244028933 1328 dbSNP
rs1475972500 1334 dbSNP
rs897515304 1335 dbSNP
rs553985673 1336 dbSNP
rs1421095840 1337 dbSNP
rs1265920265 1339 dbSNP
rs1177768641 1342 dbSNP
rs576931055 1349 dbSNP
rs1321134279 1363 dbSNP
rs895730091 1369 dbSNP
rs1287885942 1388 dbSNP
rs553592253 1390 dbSNP
rs1282320892 1391 dbSNP
rs11080320 1397 dbSNP
rs1343577442 1400 dbSNP
rs1230233841 1401 dbSNP
rs1056067028 1409 dbSNP
rs899730536 1414 dbSNP
rs1038249435 1417 dbSNP
rs1005355820 1418 dbSNP
rs111553459 1419 dbSNP
rs534075921 1424 dbSNP
rs1447733777 1430 dbSNP
rs887863516 1432 dbSNP
rs1490941886 1435 dbSNP
rs142388658 1443 dbSNP
rs1411850261 1448 dbSNP
rs1338149873 1452 dbSNP
rs1469203513 1458 dbSNP
rs1043849509 1461 dbSNP
rs1156260194 1472 dbSNP
rs946752776 1473 dbSNP
rs1431419440 1476 dbSNP
rs1348768850 1481 dbSNP
rs1302127623 1484 dbSNP
rs913935131 1490 dbSNP
rs1406509664 1509 dbSNP
rs1321053996 1511 dbSNP
rs1335044806 1515 dbSNP
rs929303997 1516 dbSNP
rs1418190302 1517 dbSNP
rs966735762 1530 dbSNP
rs147828079 1531 dbSNP
rs1274376718 1534 dbSNP
rs1281298268 1541 dbSNP
rs1351478307 1544 dbSNP
rs1245605473 1550 dbSNP
rs1289827559 1551 dbSNP
rs1362105447 1553 dbSNP
rs1223624754 1554 dbSNP
rs769506253 1560 dbSNP
rs1477025451 1563 dbSNP
rs1436506831 1564 dbSNP
rs1179059123 1574 dbSNP
rs912141566 1577 dbSNP
rs1195006965 1586 dbSNP
rs747751487 1591 dbSNP
rs953575817 1593 dbSNP
rs554581499 1594 dbSNP
rs149711763 1595 dbSNP
rs1452269963 1604 dbSNP
rs1395701329 1634 dbSNP
rs367805598 1652 dbSNP
rs1389662292 1653 dbSNP
rs1257589561 1656 dbSNP
rs1217067623 1662 dbSNP
rs1330807492 1664 dbSNP
rs1336471927 1666 dbSNP
rs990288062 1672 dbSNP
rs1315779286 1675 dbSNP
rs1279910685 1679 dbSNP
rs1385217264 1689 dbSNP
rs979479818 1692 dbSNP
rs1251050071 1706 dbSNP
rs1366902424 1711 dbSNP
rs1198146858 1712 dbSNP
rs568103119 1713 dbSNP
rs75663205 1714 dbSNP
rs924383978 1721 dbSNP
rs977113707 1728 dbSNP
rs1394624989 1730 dbSNP
rs1372356059 1732 dbSNP
rs955139491 1748 dbSNP
rs78366659 1751 dbSNP
rs140902026 1758 dbSNP
rs1402872824 1759 dbSNP
rs1334708919 1760 dbSNP
rs1171643651 1761 dbSNP
rs964313922 1771 dbSNP
rs1408587006 1777 dbSNP
rs1453724423 1787 dbSNP
rs57046081 1796 dbSNP
rs1295116180 1799 dbSNP
rs1016821517 1802 dbSNP
rs865898828 1803 dbSNP
rs1005406301 1807 dbSNP
rs886910538 1808 dbSNP
rs1271308490 1810 dbSNP
rs1323400194 1829 dbSNP
rs1202486482 1830 dbSNP
rs1423613615 1834 dbSNP
rs1260771388 1843 dbSNP
rs1193430035 1851 dbSNP
rs567051901 1852 dbSNP
rs1055716888 1853 dbSNP
rs1025468128 1857 dbSNP
rs1426545732 1875 dbSNP
rs1195016863 1886 dbSNP
rs1373581792 1887 dbSNP
rs1196957731 1888 dbSNP
rs1001832935 1895 dbSNP
rs1174162411 1898 dbSNP
rs151007832 1903 dbSNP
rs1042896185 1914 dbSNP
rs192719091 1916 dbSNP
rs1383003391 1918 dbSNP
rs1384304630 1919 dbSNP
rs560976113 1923 dbSNP
rs1345260513 1927 dbSNP
rs1222297498 1928 dbSNP
rs948717589 1929 dbSNP
rs1311400663 1931 dbSNP
rs894723966 1933 dbSNP
rs1233281900 1934 dbSNP
rs749317801 1934 dbSNP
rs1259820918 1939 dbSNP
rs1484652319 1940 dbSNP
rs537964141 1940 dbSNP
rs746569395 1950 dbSNP
rs780497182 1951 dbSNP
rs758926086 1953 dbSNP
rs1431318809 1960 dbSNP
rs1433865355 1962 dbSNP
rs1158426589 1971 dbSNP
rs1362282266 1983 dbSNP
rs1455487412 1986 dbSNP
rs1159363621 1990 dbSNP
rs746169655 1996 dbSNP
rs142536253 2000 dbSNP
rs1403469559 2006 dbSNP
rs1444122301 2007 dbSNP
rs530780893 2011 dbSNP
rs1305512464 2015 dbSNP
rs1346654883 2017 dbSNP
rs562454122 2038 dbSNP
rs1386854064 2039 dbSNP
rs1305603981 2043 dbSNP
rs953730173 2044 dbSNP
rs1240824323 2046 dbSNP
rs922369046 2047 dbSNP
rs973539451 2048 dbSNP
rs975487439 2053 dbSNP
rs963722720 2055 dbSNP
rs1271000321 2061 dbSNP
rs188511501 2063 dbSNP
rs961802143 2064 dbSNP
rs1248594437 2065 dbSNP
rs1420924901 2071 dbSNP
rs1159532385 2073 dbSNP
rs1384792798 2074 dbSNP
rs984065263 2076 dbSNP
rs1165790714 2083 dbSNP
rs951257225 2090 dbSNP
rs1379734187 2094 dbSNP
rs1176920773 2095 dbSNP
rs1366753251 2096 dbSNP
rs1461977867 2099 dbSNP
rs992945887 2101 dbSNP
rs1034399083 2106 dbSNP
rs959751167 2106 dbSNP
rs1309558425 2107 dbSNP
rs1381534396 2116 dbSNP
rs1001485412 2126 dbSNP
rs1251437241 2130 dbSNP
rs1322086683 2138 dbSNP
rs1181497966 2148 dbSNP
rs1203781675 2167 dbSNP
rs577014070 2172 dbSNP
rs1481672796 2183 dbSNP
rs904422798 2196 dbSNP
rs1025520593 2202 dbSNP
rs560275877 2205 dbSNP
rs1003367949 2208 dbSNP
rs907286805 2209 dbSNP
rs1415066766 2218 dbSNP
rs1428252968 2220 dbSNP
rs891602234 2221 dbSNP
rs757682020 2223 dbSNP
rs1052524120 2227 dbSNP
rs77916106 2235 dbSNP
rs1331347292 2236 dbSNP
rs890474881 2236 dbSNP
rs1450084296 2241 dbSNP
rs894454378 2242 dbSNP
rs1379683817 2252 dbSNP
rs1054373577 2254 dbSNP
rs1050845654 2258 dbSNP
rs1212116290 2259 dbSNP
rs34149091 2260 dbSNP
rs34577764 2264 dbSNP
rs932290903 2266 dbSNP
rs879634196 2267 dbSNP
rs185238672 2268 dbSNP
rs1284671425 2276 dbSNP
rs1237252677 2305 dbSNP
rs1262657184 2308 dbSNP
rs1355234085 2310 dbSNP
rs903444610 2310 dbSNP
rs1042313298 2312 dbSNP
rs769538710 2313 dbSNP
rs1238243719 2319 dbSNP
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rs973251450 5413 dbSNP
rs961873275 5424 dbSNP
rs751720665 5426 dbSNP
rs1331471537 5438 dbSNP
rs903265975 5446 dbSNP
rs1232095867 5455 dbSNP
rs1414698488 5460 dbSNP
rs1041755330 5462 dbSNP
rs1234773615 5480 dbSNP
rs998602522 5480 dbSNP
rs1015155731 5483 dbSNP
rs191245103 5484 dbSNP
rs1212531432 5489 dbSNP
rs1274843628 5493 dbSNP
rs1241851808 5495 dbSNP
rs1334916167 5511 dbSNP
rs186852427 5512 dbSNP
rs778665215 5521 dbSNP
rs71381414 5526 dbSNP
rs1312201288 5532 dbSNP
rs1432273740 5541 dbSNP
rs1396415679 5546 dbSNP
rs1173847276 5547 dbSNP
rs1474540536 5548 dbSNP
rs528815249 5551 dbSNP
rs751388324 5553 dbSNP
rs1048541796 5558 dbSNP
rs1043935072 5566 dbSNP
rs563650313 5568 dbSNP
rs552587025 5569 dbSNP
rs970816048 5576 dbSNP
rs892664476 5578 dbSNP
rs373843199 5579 dbSNP
rs1257386783 5582 dbSNP
rs1428211224 5594 dbSNP
rs990765459 5597 dbSNP
rs957924296 5602 dbSNP
rs181685790 5603 dbSNP
rs1278054841 5609 dbSNP
rs999760935 5614 dbSNP
rs966535984 5615 dbSNP
rs1261120474 5616 dbSNP
rs1445532280 5620 dbSNP
rs1195561609 5623 dbSNP
rs1281178612 5631 dbSNP
rs1454077855 5633 dbSNP
rs1204768946 5639 dbSNP
rs944512681 5645 dbSNP
rs1348875904 5663 dbSNP
rs1281500555 5664 dbSNP
rs1435870432 5667 dbSNP
rs1172726454 5677 dbSNP
rs890174972 5681 dbSNP
rs1050089658 5682 dbSNP
rs1380219500 5686 dbSNP
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rs1292577026 5712 dbSNP
rs901183754 5715 dbSNP
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rs1181694958 5792 dbSNP
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rs993063669 5842 dbSNP
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rs1396376897 5859 dbSNP
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rs1031646197 6440 dbSNP
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rs1175621290 6488 dbSNP
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rs1228406901 6689 dbSNP
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rs1002785194 6758 dbSNP
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rs1347160663 6790 dbSNP
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rs1266022819 7505 dbSNP
rs1466033312 7514 dbSNP
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Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000345365.6 | 3UTR | AAUCGGGCACAAGCACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.626 5.3e-4 0.728 2.8e-5 24 Click to see details
GSE27834 Pluripotent stem cells -0.372 7.8e-2 -0.279 1.5e-1 16 Click to see details
GSE21849 B cell lymphoma 0.268 8.0e-2 0.279 7.1e-2 29 Click to see details
GSE32688 Pancreatic cancer 0.247 8.6e-2 0.271 6.7e-2 32 Click to see details
GSE14794 Lymphoblastoid cells 0.142 9.1e-2 0.122 1.3e-1 90 Click to see details
GSE26953 Aortic valvular endothelial cells -0.251 1.2e-1 -0.064 3.8e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.24 1.2e-1 0.334 5.1e-2 25 Click to see details
GSE28260 Renal cortex and medulla 0.317 1.5e-1 0.308 1.5e-1 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.218 1.8e-1 0.334 7.5e-2 20 Click to see details
GSE42095 Differentiated embryonic stem cells 0.108 3.1e-1 0.179 2.1e-1 23 Click to see details
GSE21687 Ependynoma primary tumors -0.057 3.3e-1 -0.086 2.5e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.04 4.2e-1 -0.135 2.6e-1 25 Click to see details
GSE19350 CNS germ cell tumors -0.055 4.3e-1 0.229 2.4e-1 12 Click to see details
GSE38226 Liver fibrosis 0.008 4.9e-1 -0.314 8.3e-2 21 Click to see details
GSE17306 Multiple myeloma 0.004 4.9e-1 -0.100 2.5e-1 49 Click to see details
GSE17498 Multiple myeloma -0.004 4.9e-1 0.112 2.5e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.388 0 -0.325 0.01 58 Click to see details
LUSC 0.358 0.02 0.272 0.06 35 Click to see details
LIHC 0.294 0.05 0.330 0.03 34 Click to see details
KIRP 0.3 0.05 0.304 0.05 32 Click to see details
UCEC 0.352 0.07 0.282 0.12 19 Click to see details
PRAD -0.252 0.09 -0.217 0.12 31 Click to see details
KICH -0.278 0.09 -0.131 0.27 24 Click to see details
ESCA -0.369 0.15 -0.224 0.27 10 Click to see details
KIRC 0.127 0.15 0.200 0.05 68 Click to see details
COAD -0.357 0.19 -0.262 0.27 8 Click to see details
BLCA -0.277 0.2 -0.136 0.35 11 Click to see details
PCPG -0.763 0.22 -0.500 0.33 3 Click to see details
CESC 0.586 0.3 0.500 0.33 3 Click to see details
BRCA -0.04 0.36 -0.022 0.42 84 Click to see details
PAAD 0.141 0.43 -0.400 0.3 4 Click to see details
HNSC -0.027 0.44 0.015 0.47 36 Click to see details
LUAD 0.046 0.45 -0.127 0.35 11 Click to see details
STAD 0.02 0.47 -0.142 0.29 17 Click to see details
STAD 0.02 0.47 -0.142 0.29 17 Click to see details
STAD 0.02 0.47 -0.142 0.29 17 Click to see details
STAD 0.02 0.47 -0.142 0.29 17 Click to see details
36 hsa-miR-509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004915 NTRK3 neurotrophic receptor tyrosine kinase 3 2 2
MIRT007363 CFTR cystic fibrosis transmembrane conductance regulator 1 1
MIRT087758 H1F0 H1 histone family member 0 2 2
MIRT102893 INSIG1 insulin induced gene 1 2 6
MIRT152183 ZNF460 zinc finger protein 460 2 8
MIRT209722 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT218697 ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2 2
MIRT446633 SDC3 syndecan 3 2 2
MIRT449554 HES2 hes family bHLH transcription factor 2 2 2
MIRT450503 ALPK3 alpha kinase 3