miRTarBase - #MIRT484236


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pre-miRNA Information
pre-miRNA hsa-mir-1245b   
Genomic Coordinates chr2: 188978093 - 188978161
Description Homo sapiens miR-1245b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245b-3p
Sequence 42| UCAGAUGAUCUAAAGGCCUAUA |63
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs748755619 4 dbSNP
rs1270331859 8 dbSNP
rs1424666827 9 dbSNP
rs777446442 11 dbSNP
rs568426204 21 dbSNP
Putative Targets

Gene Information
Gene Symbol IER2   
Synonyms ETR101
Description immediate early response 2
Transcript NM_004907   
Expression
Putative miRNA Targets on IER2
3'UTR of IER2
(miRNA target sites are highlighted)		 
>IER2|NM_004907|3'UTR
   1 GGACCCCGAGCGGCGCTGCCGGAGCCCAGAGCGCGCGTCGAACCGTCGGCCCGAGGGCGCAGACCTGAGGCGAGGCCACC
  81 CCCCTCCATCCTGGGGGAAGCGCCCGCGAAAACCGTGGAGAGAAGCCGCCGCCCGGGCTGCTGAGAGGCCCGGAGAGGGA
 161 CTCTGTCCCCGGGGAGCCATCGCCTTCAGTGTGCAGGGACGGCACCGAGGAGTCTGAGCCGGGGGCGCGGGCGCCTTCCG
 241 CAGAGACCTGCGCCCACAGGTGCTGTCTTAGTGGACTGGGACGTGAACCTTTCGCTCTCCTTCTGGACTGGGAGAAGGGA
 321 GGCTTGGGTGTTGTGTTTTTTGTTTTGTTTGTTTGTTTGTTTTTAAAGATCTCCTCAGGGTCGGACTTCATTTTGTACTG
 401 TGGGCTGTGCTGGCCCTTTCAAGGTTTTTCAAGAGTTGGTTTTGCGTTTCCAACCTCGGAGAATTCCAGGCACTCCCCTT
 481 CCCCCTCCGCTGACATACTTGTATAAGCGGTCATCGTTGCGTCATGGGGCAGGCGTGGGGAGCTTCCTGTCGCCTTGCGT
 561 GGGTGTGGGGCCTGGGAGGAGGTCCTGGGGCGTGCACCCGCCCTGGGCAGTGGGGAGGAGAGTGGCCTGAGTTACTTCAC
 641 CCCCGCGTGCTGCTGGTTAATGTCCCGCGTCTCTGCACCTTCGGGTGGGAGCGGGGACTGATCTACTTTCACATTCTCAA
 721 GTTTTTCTCATCTGCATTAGAGGTGCCCAGTAGGTTCCCAGGTTCCAGCGTGCCCCTCCCTCAGACACACGGACACAATC
 801 AGCCGAGAAGTTCCTGGTCTGAATCACGAGAATGTGGAGGGGTGGGGGGTGTCAGTGGAAAGGCATAAGGCTGAGCTGAG
 881 ACCAGTTGCTGGTGAAACTGGGCCAATCTGGGGAGGGGAACATCCTTGCCAGGGAGTTTCTGAGGGTCTGCTTTGTTTAC
 961 CTTTCGTGCGGTGGATTCTTTTTAACTCCGTCTACCTGGCGTTTTGTTAGAAATGTCAGATAGGAAAATAAAAACCATTT
1041 GAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaUCCGGAAAUCUAGUAGACu 5'
             | |::|||   ||||||| 
Target 5' ctcAAGTTTTT--CTCATCTGc 3'
 716 - 735 151.00 -9.60
2 
miRNA  3' auaUCCGGAAAUCU--AGUAGAcu 5'
             :||:|   :||  ||||:|  
Target 5' tcaGGGTC---GGACTTCATTTtg 3'
 375 - 395 110.00 -9.00
3 
miRNA  3' auAUCCGGAAAU---CUAGUAGacu 5'
            ||  : | ||   |:|||||   
Target 5' caTACTTGTATAAGCGGTCATCgtt 3'
 494 - 518 108.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1211082 167 COSMIC
COSN30129843 254 COSMIC
COSN15624537 301 COSMIC
COSN23012648 303 COSMIC
COSN30536692 304 COSMIC
COSN31538949 328 COSMIC
COSN30113644 371 COSMIC
COSN30142911 372 COSMIC
COSN31561701 383 COSMIC
COSN30111603 469 COSMIC
COSN20115479 486 COSMIC
COSN30510001 512 COSMIC
COSN21910467 540 COSMIC
COSN28659536 599 COSMIC
COSN30538111 635 COSMIC
COSN15624538 642 COSMIC
COSN8752011 647 COSMIC
COSN30176935 683 COSMIC
COSN30176055 728 COSMIC
COSN30544421 753 COSMIC
COSN30540899 754 COSMIC
COSN30138949 762 COSMIC
COSN28690760 796 COSMIC
COSN31582581 808 COSMIC
COSN30117068 847 COSMIC
COSN30116746 863 COSMIC
COSN15624539 870 COSMIC
COSN30119715 945 COSMIC
COSN30177046 949 COSMIC
rs3745992 599 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1326674145 1 dbSNP
rs1180298068 3 dbSNP
rs1282287026 4 dbSNP
rs1332285055 4 dbSNP
rs949380260 5 dbSNP
rs1232772406 6 dbSNP
rs977993279 7 dbSNP
rs1195874534 8 dbSNP
rs924047432 9 dbSNP
rs1029260881 13 dbSNP
rs1053535976 14 dbSNP
rs566987643 15 dbSNP
rs955066847 16 dbSNP
rs985215476 17 dbSNP
rs769492741 19 dbSNP
rs943546255 21 dbSNP
rs534417532 29 dbSNP
rs973940027 36 dbSNP
rs1248525587 38 dbSNP
rs900840586 41 dbSNP
rs1463356881 42 dbSNP
rs1285772201 45 dbSNP
rs1331559930 47 dbSNP
rs1447875546 49 dbSNP
rs997862171 58 dbSNP
rs1025840425 62 dbSNP
rs1232843571 65 dbSNP
rs920768325 72 dbSNP
rs1300387317 76 dbSNP
rs1176769739 79 dbSNP
rs567734015 80 dbSNP
rs1005277589 81 dbSNP
rs1048024482 82 dbSNP
rs963500477 83 dbSNP
rs567356468 84 dbSNP
rs1390759172 102 dbSNP
rs762828814 105 dbSNP
rs1190394943 106 dbSNP
rs537406070 107 dbSNP
rs906513310 115 dbSNP
rs763842077 121 dbSNP
rs1187930046 123 dbSNP
rs1055214736 132 dbSNP
rs774239108 135 dbSNP
rs1209562947 141 dbSNP
rs1342226643 143 dbSNP
rs1011002149 146 dbSNP
rs1391975327 149 dbSNP
rs1446659815 152 dbSNP
rs1226834882 154 dbSNP
rs1339204891 156 dbSNP
rs1022521384 158 dbSNP
rs1329974494 164 dbSNP
rs1285159359 166 dbSNP
rs555782939 167 dbSNP
rs1338947762 168 dbSNP
rs577515272 171 dbSNP
rs1410555785 176 dbSNP
rs999380863 179 dbSNP
rs1372476994 182 dbSNP
rs1029564328 185 dbSNP
rs915076570 188 dbSNP
rs538577887 189 dbSNP
rs1418626396 191 dbSNP
rs553920721 194 dbSNP
rs36093561 201 dbSNP
rs139160847 202 dbSNP
rs1017940989 206 dbSNP
rs1046741520 208 dbSNP
rs113016450 212 dbSNP
rs1239961062 213 dbSNP
rs1202317914 215 dbSNP
rs1437789641 219 dbSNP
rs973860497 221 dbSNP
rs766430851 228 dbSNP
rs1292974639 230 dbSNP
rs1267403533 232 dbSNP
rs1255662028 236 dbSNP
rs1352493364 241 dbSNP
rs1306268289 247 dbSNP
rs1441519330 248 dbSNP
rs1353885559 249 dbSNP
rs929482766 252 dbSNP
rs1415388292 256 dbSNP
rs963574185 257 dbSNP
rs1422269109 258 dbSNP
rs983689160 260 dbSNP
rs1413660140 261 dbSNP
rs928242698 263 dbSNP
rs530076348 265 dbSNP
rs1465454965 266 dbSNP
rs1169115151 272 dbSNP
rs939623811 276 dbSNP
rs1055503212 280 dbSNP
rs895163291 286 dbSNP
rs1272958622 288 dbSNP
rs1209676853 289 dbSNP
rs1286634868 290 dbSNP
rs1223343055 294 dbSNP
rs946767667 295 dbSNP
rs1368362267 297 dbSNP
rs1043814277 298 dbSNP
rs902342974 302 dbSNP
rs1392130149 304 dbSNP
rs192123390 307 dbSNP
rs1397381651 309 dbSNP
rs1390444779 322 dbSNP
rs1156454748 328 dbSNP
rs982742594 329 dbSNP
rs999349824 331 dbSNP
rs923982050 333 dbSNP
rs1216600539 335 dbSNP
rs1189640314 336 dbSNP
rs1252878174 336 dbSNP
rs956664566 337 dbSNP
rs1050966683 338 dbSNP
rs1259229398 344 dbSNP
rs1280844807 344 dbSNP
rs915317026 344 dbSNP
rs989530376 344 dbSNP
rs891001744 352 dbSNP
rs1368725699 364 dbSNP
rs1209405804 369 dbSNP
rs1255482805 371 dbSNP
rs1435593274 375 dbSNP
rs1367087562 386 dbSNP
rs1286812062 399 dbSNP
rs1452619275 408 dbSNP
rs1177640101 413 dbSNP
rs1432273726 414 dbSNP
rs182334732 415 dbSNP
rs1395067298 416 dbSNP
rs1482346800 417 dbSNP
rs1006816106 420 dbSNP
rs544613874 422 dbSNP
rs1169752314 425 dbSNP
rs1018328608 426 dbSNP
rs962421393 436 dbSNP
rs975262804 437 dbSNP
rs562898005 438 dbSNP
rs375649691 456 dbSNP
rs1483704828 458 dbSNP
rs933942641 458 dbSNP
rs1477662736 470 dbSNP
rs1191974395 476 dbSNP
rs138568916 481 dbSNP
rs1025427076 482 dbSNP
rs1279602325 483 dbSNP
rs886785994 485 dbSNP
rs940998608 490 dbSNP
rs1176031125 495 dbSNP
rs533651931 498 dbSNP
rs894211788 500 dbSNP
rs545679125 501 dbSNP
rs1412431671 511 dbSNP
rs1169846268 518 dbSNP
rs1432183996 524 dbSNP
rs983581859 525 dbSNP
rs928126564 528 dbSNP
rs1170229866 529 dbSNP
rs1424736615 531 dbSNP
rs34440056 532 dbSNP
rs1012448158 535 dbSNP
rs111958427 540 dbSNP
rs1485419009 541 dbSNP
rs1023818048 547 dbSNP
rs1207296964 548 dbSNP
rs991107001 552 dbSNP
rs1481592194 560 dbSNP
rs1397844359 565 dbSNP
rs527832796 577 dbSNP
rs1322072074 579 dbSNP
rs549562378 581 dbSNP
rs1279842878 586 dbSNP
rs753925123 588 dbSNP
rs569035994 592 dbSNP
rs1354368895 595 dbSNP
rs3745992 599 dbSNP
rs531352568 602 dbSNP
rs1218552472 608 dbSNP
rs1299133580 609 dbSNP
rs549344907 610 dbSNP
rs570945327 611 dbSNP
rs1298074659 612 dbSNP
rs1411087876 612 dbSNP
rs142558681 614 dbSNP
rs1310479296 615 dbSNP
rs1212343406 634 dbSNP
rs553756982 639 dbSNP
rs1163149363 640 dbSNP
rs1351970742 640 dbSNP
rs935420097 641 dbSNP
rs1417379096 642 dbSNP
rs1248385975 643 dbSNP
rs1488080232 646 dbSNP
rs534457637 647 dbSNP
rs1274832753 656 dbSNP
rs1050849595 657 dbSNP
rs890974909 660 dbSNP
rs565969820 662 dbSNP
rs964111593 665 dbSNP
rs1265762245 666 dbSNP
rs536021454 667 dbSNP
rs1240607708 668 dbSNP
rs1039646431 669 dbSNP
rs117839062 670 dbSNP
rs749323226 678 dbSNP
rs1387869600 680 dbSNP
rs1373743513 688 dbSNP
rs922464138 689 dbSNP
rs558024552 692 dbSNP
rs1423719102 703 dbSNP
rs1434326954 704 dbSNP
rs1176170222 705 dbSNP
rs112661888 708 dbSNP
rs752914709 710 dbSNP
rs1199599263 717 dbSNP
rs1433709619 720 dbSNP
rs1254775631 723 dbSNP
rs577894923 725 dbSNP
rs1258765758 730 dbSNP
rs1467852444 733 dbSNP
rs779866939 736 dbSNP
rs1206510616 737 dbSNP
rs1002639729 740 dbSNP
rs1035165582 746 dbSNP
rs778351636 749 dbSNP
rs991467461 750 dbSNP
rs1233289880 785 dbSNP
rs746891890 787 dbSNP
rs916873124 792 dbSNP
rs968451558 794 dbSNP
rs1366374491 797 dbSNP
rs1320598495 804 dbSNP
rs1380759278 805 dbSNP
rs768309216 806 dbSNP
rs1291646967 808 dbSNP
rs1173269909 812 dbSNP
rs1369657958 814 dbSNP
rs1219803359 815 dbSNP
rs1038029263 822 dbSNP
rs1171676879 823 dbSNP
rs894116925 825 dbSNP
rs1453631482 828 dbSNP
rs923950419 829 dbSNP
rs1194975415 831 dbSNP
rs780814654 833 dbSNP
rs948515954 835 dbSNP
rs1200582098 839 dbSNP
rs1353132888 844 dbSNP
rs1278898660 845 dbSNP
rs1234185202 847 dbSNP
rs544749102 849 dbSNP
rs1272293947 850 dbSNP
rs1326100536 856 dbSNP
rs556707766 859 dbSNP
rs1373692680 860 dbSNP
rs1312286507 865 dbSNP
rs1434028564 870 dbSNP
rs1420087171 873 dbSNP
rs747507165 878 dbSNP
rs757854341 880 dbSNP
rs912364078 884 dbSNP
rs11540422 894 dbSNP
rs972991154 901 dbSNP
rs1031288720 907 dbSNP
rs780783839 909 dbSNP
rs1317851562 918 dbSNP
rs1254794274 925 dbSNP
rs1209447680 934 dbSNP
rs1221298340 944 dbSNP
rs1213231648 952 dbSNP
rs1275666464 952 dbSNP
rs1285064207 956 dbSNP
rs942576346 956 dbSNP
rs578050884 961 dbSNP
rs3174806 970 dbSNP
rs1011088003 974 dbSNP
rs898449957 975 dbSNP
rs1330772954 976 dbSNP
rs1355090969 976 dbSNP
rs1408066501 979 dbSNP
rs1022273287 984 dbSNP
rs1395492224 984 dbSNP
rs371793538 987 dbSNP
rs140052624 989 dbSNP
rs1475986786 990 dbSNP
rs769282711 991 dbSNP
rs754028846 992 dbSNP
rs1236999553 995 dbSNP
rs1437302838 1001 dbSNP
rs1160044037 1007 dbSNP
rs775185485 1009 dbSNP
rs1235144561 1011 dbSNP
rs1203033823 1015 dbSNP
rs931228243 1018 dbSNP
rs1291039289 1023 dbSNP
rs1215895633 1025 dbSNP
rs1046737122 1027 dbSNP
rs1332986764 1030 dbSNP
rs554357531 1035 dbSNP
rs1229131102 1036 dbSNP
rs1404490299 1037 dbSNP
rs1281272133 1039 dbSNP
rs955274334 1045 dbSNP
rs1351474828 1046 dbSNP
rs1437074127 1052 dbSNP
rs1330653728 1053 dbSNP
rs1002607192 1054 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaUCCGGAAAUCUAGUAGAcu 5'
             | |::|||   ||||||  
Target 5' cucAAGUUUUU--CUCAUCU-- 3'
 		16 - 33
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000292433.3 | 3UTR | AUCUACUUUCACAUUCUCAAGUUUUUCUCAUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-1245b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087132 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT093398 TMA16 translation machinery associated 16 homolog 2 2
MIRT096092 SFXN1 sideroflexin 1 2 2
MIRT097106 TNPO1 transportin 1 2 4
MIRT241837 SLC38A2 solute carrier family 38 member 2 2 2
MIRT271432 ETNK1 ethanolamine kinase 1 2 2
MIRT329517 E2F3 E2F transcription factor 3 2 4
MIRT444201 SESN3 sestrin 3 2 2
MIRT445920 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT450210 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT455192 AGTRAP angiotensin II receptor associated protein 2 2
MIRT455458 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT459016 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT461492 KIAA1009 centrosomal protein 162 1 1
MIRT466306 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT471143 PHF19 PHD finger protein 19 2 2
MIRT473481 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT473564 MATR3 matrin 3 2 2
MIRT474013 LRRC20 leucine rich repeat containing 20 2 2
MIRT475982 GTPBP2 GTP binding protein 2 2 2
MIRT478926 CPNE3 copine 3 2 2
MIRT479896 CCDC117 coiled-coil domain containing 117 2 2
MIRT480115 CALR calreticulin 2 2
MIRT483127 ONECUT3 one cut homeobox 3 2 2
MIRT484236 IER2 immediate early response 2 2 2
MIRT492237 SLC48A1 solute carrier family 48 member 1 2 2
MIRT496934 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT500438 ZMAT3 zinc finger matrin-type 3 2 2
MIRT506263 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT525649 NHSL2 NHS like 2 2 2
MIRT526691 BAK1 BCL2 antagonist/killer 1 2 2
MIRT529667 SLC28A1 solute carrier family 28 member 1 2 2
MIRT531152 CYGB cytoglobin 2 2
MIRT537002 GTPBP10 GTP binding protein 10 2 2
MIRT537325 FOXN3 forkhead box N3 2 2
MIRT537586 ESYT2 extended synaptotagmin 2 2 2
MIRT538786 C6orf89 chromosome 6 open reading frame 89 2 2
MIRT540286 RGR retinal G protein coupled receptor 2 4
MIRT552700 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 2
MIRT555670 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT556823 KDELR2 KDEL endoplasmic reticulum protein retention receptor 2 2 2
MIRT568686 TOMM40 translocase of outer mitochondrial membrane 40 2 2
MIRT568851 VPS53 VPS53, GARP complex subunit 2 2
MIRT571973 KIF21A kinesin family member 21A 2 2
MIRT573973 DDX21 DExD-box helicase 21 2 2
MIRT574260 DOCK7 dedicator of cytokinesis 7 2 2
MIRT612180 EMC3 ER membrane protein complex subunit 3 2 2
MIRT619387 KLHL12 kelch like family member 12 2 2
MIRT625708 SHROOM1 shroom family member 1 2 2
MIRT646803 EVC2 EvC ciliary complex subunit 2 2 2
MIRT656992 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT676250 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT682591 CPA4 carboxypeptidase A4 2 2
MIRT687779 KHSRP KH-type splicing regulatory protein 2 2
MIRT690292 ZNF154 zinc finger protein 154 2 2
MIRT692718 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700284 RAN RAN, member RAS oncogene family 2 2
MIRT708293 ZNF24 zinc finger protein 24 2 2
MIRT709767 GPR183 G protein-coupled receptor 183 2 2
MIRT720689 LY6K lymphocyte antigen 6 family member K 2 2
MIRT722784 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT725414 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245b-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1245b-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1245b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1245b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-1245b-3p Palbociclib 5330286 NSC758247 approved sensitive tissue (breast cancer)
hsa-miR-1245b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-1245b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-1245b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-1245b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-1245b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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