miRTarBase - #MIRT484684


—
pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PACSIN1   
Synonyms SDPI
Description protein kinase C and casein kinase substrate in neurons 1
Transcript NM_020804   
Expression
Putative miRNA Targets on PACSIN1
3'UTR of PACSIN1
(miRNA target sites are highlighted)		 
>PACSIN1|NM_020804|3'UTR
   1 AGGCCCCCTCCCTCCATACTCCCGTCACTCCTCCCCACTGCCGCCCCTCCCCTCCCACTCTCGTCTCCTTCCCCTCGCCA
  81 TAGAGTTCCAGACATATTTTCCGATCAAGCTTTTATTTTTTTAAAAGTCAAAACAGAACAAAACAAAGTATGCAGAGACA
 161 GAGCATTTGCAGGGCCACCTGGAGGCTGGGGTGCTGGGGCTTGGGGTGGCCCCAGGGTAGGTAACAGTCTTAGGACTTAG
 241 CCCAACATCACAACATCTGCTCTTCGGGTTCCACCAAAGAGTCTCCTGAGCCCTGAGGGATGGATGTCTCCTGACCCTTC
 321 CACCCCGCCTCACTCCCTCCGTCCCACTCCACTCCAGGCTGCCGGCACCTGCCCCATTCCCTGGCCTGGTTTCCTAACCT
 401 CTTCTTCCTCCCCTGCCCTGCTTCCCTTCCTCCACCACCCTGCTCTCAAAGGCCTCCTCTCCAGACCCCTGGAAGGGAGG
 481 CTTCCCCATCTTTAGTTTTCCACTCTGCCCCGGGGAGCACCCTTCTACTCCTAGCCACGTCCCTTGGGACCGGTGGGACT
 561 GGAGGAGGAACGGTCACCCTCCTCCCCCATGGAGGTTTCCAGGGGTCCCCCAGACATGAAAGAGGGGTGAGCTGGAGGAA
 641 GTCATGGTGTCACTGGGGTACAGGAGGGTGAATGAAGGGCATGCAGGCCCTCAGCCCGGGCTGTGCCAGCCCTCCCAGCC
 721 CCAGGCCCATCTGAGGGACCAAGACGCTGTTACGCAGGCCCTTCTTTCCAGCTATCAGCACTTTCAGCATCGGCTCTTCA
 801 GCAGATCCAAACCCCCTCAGCAACTTGCAGAGGACCTGTCCCCTCTCAAAAGTCCCCTGGCCTAGGGTGGGGACCCCCAA
 881 ACCTACGGCAAAGCCAGCAACAGTAGCAGCCTGCTCCCATTTGCTGGGGAGGAGATCATCTTGTTCCCCTGGCCCCCCAC
 961 TCTCCCTCCATGTCCATCCAAAAACCATAAAATCACTGGGTTCCACATCAGCCTCCATGAGGCCAAGCCTTGTACCTGCA
1041 AGGCTCTTGGCCTAACCATTCCTCTGTCCTCTTCTCTGGCCTGCCTGGGGAGCCCGTGAAGGCCGCACGGGTGCCTCCAG
1121 CCTGAGACATCAGGGGAGAGCCTGCAGCTGAGTTCAGCAGAAAGGAGGAATCCTGGCCCTCAGGAAGAAGATAGTCACAT
1201 GTTTTTCTTCCTTGTCCCCACGGCCCCCAGAACAACATTCTCCCTGCTGGCAGCCCTTCCATGTCTCCAAACCTGGGTCA
1281 GAGTGAAAGGACCTTTGGGGGTGGGTGGGAGCAAAGGGCCCACCTGCTGGTTGGTGAAAGCAGTGGTGCCGGAGTGCTAG
1361 GTACCGCACGAGAGGGTGCGGGGGCTTGGGAAGCAGACCAGGGTTGGACAAAACCCCATGAGGGCGGGGAGCTGGAAGAA
1441 AAGTCTCTTGGGGACCTCTGGGGCAAGGAGCTGAGAAGTCCTGCAGCACCAGGTGAGACTTGCTTACAGTGGATGCCACT
1521 TCTAGGCCTCTGGACCGCAGATGCCCTCCTCCCTCCTGCACACCTGGCCTCCTGGGCCTCCAGGTAAAGAGAGAGAGCCA
1601 GCCCAGCCCTGTTTCCCCTCAGTCCTCCTTTGCTCCTGCTGCTTCTCCCAACAGCCCACTGTTAGGAGGTAGTAGACCCC
1681 AGCCTCAAGGCTCTGACCTTCTTCATGTGGGCACAGAGGGTCCTGACACTCTGGCAGGGCCTGAGCTGGGGCAGGCCTCC
1761 CTCAGGGCCAGGGGCGATGGCACCCCGGGGACAGGCAGACCTCCTTCCTGCCGTCAGCACCCCCTTCCTTATCACTGTCT
1841 GGTCTCCGAGCTTCGGCTGCAGCCTGAGGTGTGTCCTGGGCTCCTCAGAGCCTGAAGCAAGCTTTTGGAAGCCTGCAGTC
1921 CTCCCAGCTCCAGTGCAGAAGCCTCTCTCTCCAGCCTTTCCCCAGGCAGGAGTTGGGGTTGGGGGCCTCTGTCCCTCATC
2001 GCTTACCTTGGAAAGGTGGGAAGCTGGCAATCTGCACCTTGGGGCCTGGGCTCCCCCTCTCTGTGCCAGCGGCTTCCCAG
2081 CACCTGGGAGGGGCTGCAGCCCCAGCTGGACTCCAGCCTGTCCCTCTTAGCACTCTAGCTGCCCACTCCAGGGCAGGGAC
2161 TCGAAACCCCCTCCGTCCTGAGCAGCCACCTCCAGGGCCCTGTTTGGGACCACTCTCTCAGTCCCCAGGTCCTCAGGGCC
2241 CCAGAGCGGGAGGGTCTCCTACCTGGAAGTCCCCCTGAGCTCCAGGGCCCAGCCCTACCTGCCAGTGCTGGTGTCAGGGC
2321 ACTCAACACCGAGTGTGGGGGCCACGCCCCTTGCCATGCCCACGGCCTCCTCCTGTAGCTCCTGCCTGCACCCACGATGC
2401 TGCACGGGCCCGCCCTGGTGGGGCTCGGCGAGTAATGTGTTTTGTCCCCAGTTAACCACCATTCTGCGGCCTGGTTCTGC
2481 AAGGAACCAGGGCTGCCCCACCGCCCGCCGTCTGCCGCCCTAGGCTTCCTGACTCCATTAGTTCCGACACTTGTGAAACT
2561 CCGAGAAGTGCTGTGGTCTCAGCAATGCACCTGTTTTGTACATGATTGTGTAATTTAAAGGTATATAAATACAAATATAT
2641 ATATATATCAGTTGTGATTGTATGACTGTGGATAAAATCCAGAACTGTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
2721 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgucGGUCGAGAUG--GGGGCGGu 5'
              |:: | || |  ||||||| 
Target 5' tctcCTGACCCTTCCACCCCGCCt 3'
 307 - 330 148.00 -18.90
2 
miRNA  3' cgucGGUCGAG--AUGGGGGCGGu 5'
              :|: |||  | |||:|||| 
Target 5' actcTCGTCTCCTTCCCCTCGCCa 3'
 57 - 80 140.00 -22.80
3 
miRNA  3' cgUCGGUCGAGA---UGGGGGCGGu 5'
            | ||  :|||    ||||:||| 
Target 5' ctAACCTCTTCTTCCTCCCCTGCCc 3'
 394 - 418 136.00 -21.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26635430 4 COSMIC
COSN30537605 149 COSMIC
COSN31596608 179 COSMIC
COSN24388175 215 COSMIC
COSN26572862 337 COSMIC
COSN16164446 813 COSMIC
COSN26264967 835 COSMIC
COSN19390696 1222 COSMIC
COSN6590704 1244 COSMIC
COSN6319114 1349 COSMIC
COSN17925136 1380 COSMIC
COSN29405153 1515 COSMIC
COSN24973820 1545 COSMIC
COSN14824301 1729 COSMIC
COSN31526464 1860 COSMIC
COSN32065495 1942 COSMIC
COSN28667806 1943 COSMIC
COSN31517058 2001 COSMIC
COSN30165111 2136 COSMIC
COSN31523971 2298 COSMIC
COSN30542350 2307 COSMIC
COSN30171690 2394 COSMIC
COSN7871258 2413 COSMIC
COSN31588249 2491 COSMIC
COSN29769926 2648 COSMIC
rs78065686 1380 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1277743536 2 dbSNP
rs901228071 3 dbSNP
rs1245080919 4 dbSNP
rs1211699728 5 dbSNP
rs142849257 5 dbSNP
rs373659537 5 dbSNP
rs994137808 6 dbSNP
rs1485806358 7 dbSNP
rs768399202 8 dbSNP
rs201465307 10 dbSNP
rs752051593 13 dbSNP
rs757858655 15 dbSNP
rs781577803 17 dbSNP
rs1196828678 19 dbSNP
rs750721747 22 dbSNP
rs1323268741 23 dbSNP
rs1480484856 29 dbSNP
rs1177521725 30 dbSNP
rs1362022560 31 dbSNP
rs1395839078 34 dbSNP
rs984801411 42 dbSNP
rs1452941396 43 dbSNP
rs1289271498 44 dbSNP
rs908865347 45 dbSNP
rs371850805 46 dbSNP
rs1490248277 53 dbSNP
rs1160044513 58 dbSNP
rs971707650 58 dbSNP
rs1423373212 65 dbSNP
rs1191835457 74 dbSNP
rs1255402765 78 dbSNP
rs1434273217 81 dbSNP
rs1454812420 89 dbSNP
rs1006165775 90 dbSNP
rs1016566112 93 dbSNP
rs1215495277 95 dbSNP
rs1484741053 102 dbSNP
rs1259956558 103 dbSNP
rs1158805891 106 dbSNP
rs922990670 109 dbSNP
rs1300877047 114 dbSNP
rs1232924465 124 dbSNP
rs1371096558 130 dbSNP
rs969896515 132 dbSNP
rs1381047542 146 dbSNP
rs1001328045 158 dbSNP
rs933106532 164 dbSNP
rs1050217504 166 dbSNP
rs888973267 171 dbSNP
rs1373857661 175 dbSNP
rs1035444652 182 dbSNP
rs1173326064 183 dbSNP
rs1435350128 191 dbSNP
rs1396984820 192 dbSNP
rs959809164 201 dbSNP
rs1186871199 203 dbSNP
rs1393295064 204 dbSNP
rs375249822 207 dbSNP
rs113400393 211 dbSNP
rs1277667235 223 dbSNP
rs1459352632 228 dbSNP
rs1209723277 241 dbSNP
rs1347911857 244 dbSNP
rs747717898 251 dbSNP
rs1281883348 272 dbSNP
rs1043339431 274 dbSNP
rs1186316450 276 dbSNP
rs559373691 276 dbSNP
rs1326335666 281 dbSNP
rs1257243330 284 dbSNP
rs988966554 288 dbSNP
rs1296997388 290 dbSNP
rs530030352 293 dbSNP
rs1019975151 294 dbSNP
rs1353962799 307 dbSNP
rs1368189757 311 dbSNP
rs1415656312 313 dbSNP
rs968778967 316 dbSNP
rs979052372 325 dbSNP
rs748371205 327 dbSNP
rs895894764 328 dbSNP
rs942875862 329 dbSNP
rs541657259 331 dbSNP
rs1013042895 333 dbSNP
rs1334484138 341 dbSNP
rs1186734097 342 dbSNP
rs922766880 345 dbSNP
rs930085191 346 dbSNP
rs1211839954 352 dbSNP
rs1267351811 360 dbSNP
rs1252339737 364 dbSNP
rs1338262638 364 dbSNP
rs1023114714 366 dbSNP
rs1047576788 376 dbSNP
rs888466908 380 dbSNP
rs984318651 382 dbSNP
rs771445373 384 dbSNP
rs1390826333 385 dbSNP
rs1183355215 399 dbSNP
rs1416660054 400 dbSNP
rs1298628960 416 dbSNP
rs181379981 420 dbSNP
rs531646737 422 dbSNP
rs751981141 436 dbSNP
rs1475446441 440 dbSNP
rs961615016 441 dbSNP
rs185610635 444 dbSNP
rs1461409668 456 dbSNP
rs1436669619 457 dbSNP
rs76810808 467 dbSNP
rs372322743 490 dbSNP
rs546278787 494 dbSNP
rs1273171306 506 dbSNP
rs1234275186 508 dbSNP
rs1337410066 509 dbSNP
rs566238378 512 dbSNP
rs922980990 513 dbSNP
rs933054284 517 dbSNP
rs891698253 529 dbSNP
rs1336383082 530 dbSNP
rs1292476658 531 dbSNP
rs1355033129 536 dbSNP
rs1231727940 538 dbSNP
rs1314930476 539 dbSNP
rs781469986 540 dbSNP
rs1461711368 551 dbSNP
rs1392635265 552 dbSNP
rs541005436 553 dbSNP
rs770856298 554 dbSNP
rs968433214 566 dbSNP
rs548762037 569 dbSNP
rs1018490260 572 dbSNP
rs903062713 581 dbSNP
rs1474020370 588 dbSNP
rs1183296919 589 dbSNP
rs1414089823 590 dbSNP
rs1427342957 592 dbSNP
rs1167746881 593 dbSNP
rs570268354 593 dbSNP
rs537118044 595 dbSNP
rs1057150412 596 dbSNP
rs976969520 597 dbSNP
rs1262777574 603 dbSNP
rs1232178743 608 dbSNP
rs1370348781 609 dbSNP
rs922801509 615 dbSNP
rs1441582110 624 dbSNP
rs1373465652 633 dbSNP
rs1413147195 636 dbSNP
rs1315930988 638 dbSNP
rs1012992370 650 dbSNP
rs1304747599 654 dbSNP
rs1160088527 655 dbSNP
rs1380170364 657 dbSNP
rs1214017943 663 dbSNP
rs558701970 664 dbSNP
rs1344899741 671 dbSNP
rs888557767 685 dbSNP
rs770441726 689 dbSNP
rs1229874795 691 dbSNP
rs1280048188 695 dbSNP
rs1448006855 696 dbSNP
rs774335210 698 dbSNP
rs778533158 699 dbSNP
rs1237658529 700 dbSNP
rs981397937 703 dbSNP
rs867546288 704 dbSNP
rs1015798029 711 dbSNP
rs1347014556 713 dbSNP
rs961605496 715 dbSNP
rs998418104 722 dbSNP
rs1326815835 724 dbSNP
rs1299598543 727 dbSNP
rs576906801 729 dbSNP
rs745337040 731 dbSNP
rs1045505079 746 dbSNP
rs1029942465 747 dbSNP
rs115104074 748 dbSNP
rs1417986185 754 dbSNP
rs375076299 755 dbSNP
rs1449998446 756 dbSNP
rs1186032105 761 dbSNP
rs752362991 763 dbSNP
rs760274959 770 dbSNP
rs1172993815 771 dbSNP
rs1212326239 772 dbSNP
rs910256991 788 dbSNP
rs143905727 792 dbSNP
rs1213937705 793 dbSNP
rs978992918 800 dbSNP
rs924476937 805 dbSNP
rs934545282 817 dbSNP
rs1303136247 822 dbSNP
rs1449503461 824 dbSNP
rs895666021 831 dbSNP
rs1010463590 833 dbSNP
rs765588377 837 dbSNP
rs1044404962 847 dbSNP
rs1163201123 868 dbSNP
rs1359911680 878 dbSNP
rs1430337619 880 dbSNP
rs144248224 883 dbSNP
rs1479669196 884 dbSNP
rs566493350 887 dbSNP
rs73746680 888 dbSNP
rs1458140810 895 dbSNP
rs1259981130 896 dbSNP
rs963668581 899 dbSNP
rs190717135 902 dbSNP
rs1221250495 914 dbSNP
rs575111193 928 dbSNP
rs527857073 933 dbSNP
rs897358516 944 dbSNP
rs1029845619 947 dbSNP
rs1279846376 948 dbSNP
rs1315924955 955 dbSNP
rs148709618 956 dbSNP
rs1370491456 973 dbSNP
rs775552830 1010 dbSNP
rs574515425 1011 dbSNP
rs1464908328 1016 dbSNP
rs142464756 1021 dbSNP
rs549713280 1029 dbSNP
rs1403075650 1033 dbSNP
rs1324472794 1048 dbSNP
rs1461197167 1051 dbSNP
rs780702350 1052 dbSNP
rs1478980612 1065 dbSNP
rs1191531926 1067 dbSNP
rs1417522517 1078 dbSNP
rs752172119 1081 dbSNP
rs547463266 1084 dbSNP
rs1177838376 1092 dbSNP
rs939307159 1096 dbSNP
rs1057090898 1097 dbSNP
rs1191684374 1102 dbSNP
rs1467829572 1105 dbSNP
rs559708526 1106 dbSNP
rs1265847952 1109 dbSNP
rs755088007 1110 dbSNP
rs955827809 1130 dbSNP
rs530286981 1133 dbSNP
rs548923218 1137 dbSNP
rs1391115368 1138 dbSNP
rs570231393 1139 dbSNP
rs1041977048 1140 dbSNP
rs1301811720 1145 dbSNP
rs917131524 1147 dbSNP
rs948698807 1148 dbSNP
rs543479284 1158 dbSNP
rs1000377458 1168 dbSNP
rs1044789419 1173 dbSNP
rs1452156137 1177 dbSNP
rs537627151 1179 dbSNP
rs1159478932 1182 dbSNP
rs1421530205 1183 dbSNP
rs1393375286 1191 dbSNP
rs1275803312 1192 dbSNP
rs7767802 1200 dbSNP
rs1222435683 1201 dbSNP
rs144448387 1213 dbSNP
rs1268034583 1218 dbSNP
rs1269551814 1222 dbSNP
rs913014 1223 dbSNP
rs748364219 1228 dbSNP
rs1241096976 1235 dbSNP
rs897265596 1265 dbSNP
rs998272359 1280 dbSNP
rs552647432 1288 dbSNP
rs769934602 1291 dbSNP
rs574394962 1293 dbSNP
rs1051215617 1294 dbSNP
rs146604931 1299 dbSNP
rs1222292613 1302 dbSNP
rs75522632 1304 dbSNP
rs1380820193 1317 dbSNP
rs1361714817 1319 dbSNP
rs1298980057 1328 dbSNP
rs951750070 1335 dbSNP
rs1373917672 1341 dbSNP
rs182905448 1346 dbSNP
rs1017541233 1351 dbSNP
rs532497849 1352 dbSNP
rs1178153673 1354 dbSNP
rs564344597 1362 dbSNP
rs372615804 1366 dbSNP
rs926672138 1367 dbSNP
rs1324716379 1370 dbSNP
rs41269042 1371 dbSNP
rs78065686 1380 dbSNP
rs559462033 1381 dbSNP
rs941349814 1394 dbSNP
rs530124305 1411 dbSNP
rs1353787735 1418 dbSNP
rs548638033 1419 dbSNP
rs1312576605 1420 dbSNP
rs945994434 1426 dbSNP
rs376791892 1427 dbSNP
rs925790905 1431 dbSNP
rs1304472544 1455 dbSNP
rs1051200739 1460 dbSNP
rs889982770 1462 dbSNP
rs942931978 1469 dbSNP
rs1478718690 1471 dbSNP
rs1043954406 1473 dbSNP
rs1186419288 1481 dbSNP
rs771529039 1484 dbSNP
rs187928254 1491 dbSNP
rs1193614958 1509 dbSNP
rs1039428753 1514 dbSNP
rs1480581141 1519 dbSNP
rs1259336838 1529 dbSNP
rs1200913306 1531 dbSNP
rs1333160158 1532 dbSNP
rs899556842 1537 dbSNP
rs997882138 1538 dbSNP
rs1342525217 1550 dbSNP
rs1436034602 1552 dbSNP
rs1050755136 1553 dbSNP
rs1399451793 1561 dbSNP
rs1331960338 1562 dbSNP
rs1466939196 1563 dbSNP
rs531279027 1564 dbSNP
rs891549503 1565 dbSNP
rs1458058932 1584 dbSNP
rs1369857550 1586 dbSNP
rs1014036717 1588 dbSNP
rs1438542320 1627 dbSNP
rs1239310638 1629 dbSNP
rs1181114860 1638 dbSNP
rs1467395451 1657 dbSNP
rs886756690 1659 dbSNP
rs1024132421 1662 dbSNP
rs1259191210 1674 dbSNP
rs1187570829 1686 dbSNP
rs552795203 1692 dbSNP
rs571027954 1698 dbSNP
rs1016815161 1706 dbSNP
rs1017160406 1710 dbSNP
rs1368736936 1712 dbSNP
rs191798742 1715 dbSNP
rs3734362 1716 dbSNP
rs765349019 1738 dbSNP
rs1392347276 1739 dbSNP
rs1033773430 1741 dbSNP
rs1380425958 1746 dbSNP
rs144905713 1746 dbSNP
rs1159968538 1747 dbSNP
rs986873068 1756 dbSNP
rs992242363 1767 dbSNP
rs1414565628 1768 dbSNP
rs1331716093 1773 dbSNP
rs911307709 1776 dbSNP
rs942858989 1777 dbSNP
rs1216224551 1784 dbSNP
rs1044286519 1787 dbSNP
rs1021397736 1788 dbSNP
rs1345570984 1790 dbSNP
rs966723806 1799 dbSNP
rs1350759399 1813 dbSNP
rs977760215 1814 dbSNP
rs1436923550 1823 dbSNP
rs538732870 1824 dbSNP
rs935844354 1831 dbSNP
rs935604133 1832 dbSNP
rs975250309 1835 dbSNP
rs760317018 1838 dbSNP
rs1299436751 1843 dbSNP
rs1230609867 1848 dbSNP
rs763659276 1849 dbSNP
rs1425077974 1855 dbSNP
rs45537738 1856 dbSNP
rs1371743312 1861 dbSNP
rs1193434592 1866 dbSNP
rs1488710820 1880 dbSNP
rs1013941293 1881 dbSNP
rs1045459833 1887 dbSNP
rs1254287330 1889 dbSNP
rs905610680 1898 dbSNP
rs1280163623 1913 dbSNP
rs1347082705 1914 dbSNP
rs1001340684 1915 dbSNP
rs568798774 1916 dbSNP
rs1340679782 1931 dbSNP
rs1188304349 1932 dbSNP
rs962602673 1933 dbSNP
rs539473062 1943 dbSNP
rs994070998 1943 dbSNP
rs1416615705 1948 dbSNP
rs865905352 1953 dbSNP
rs1448199517 1971 dbSNP
rs535585198 1972 dbSNP
rs1170340089 1974 dbSNP
rs1478354740 1982 dbSNP
rs986783189 1988 dbSNP
rs539356119 1998 dbSNP
rs1171214010 2001 dbSNP
rs1039030708 2002 dbSNP
rs898716058 2003 dbSNP
rs1002449996 2017 dbSNP
rs1318409160 2026 dbSNP
rs112628104 2030 dbSNP
rs1279675612 2032 dbSNP
rs763397439 2037 dbSNP
rs1317020251 2039 dbSNP
rs1284224291 2049 dbSNP
rs1449601301 2051 dbSNP
rs1375240866 2054 dbSNP
rs557623210 2058 dbSNP
rs1021014082 2059 dbSNP
rs967115265 2060 dbSNP
rs979423235 2063 dbSNP
rs1298157642 2071 dbSNP
rs1032749456 2072 dbSNP
rs918190572 2074 dbSNP
rs1001608860 2077 dbSNP
rs957321687 2079 dbSNP
rs1468731772 2092 dbSNP
rs949659598 2093 dbSNP
rs1045816176 2100 dbSNP
rs1458022538 2104 dbSNP
rs975280274 2107 dbSNP
rs1259707495 2118 dbSNP
rs1219136098 2120 dbSNP
rs921124316 2121 dbSNP
rs1257592100 2130 dbSNP
rs1347355091 2136 dbSNP
rs548603725 2147 dbSNP
rs1309140896 2158 dbSNP
rs986975497 2163 dbSNP
rs1001728116 2164 dbSNP
rs1283632473 2168 dbSNP
rs1179272980 2169 dbSNP
rs1038190155 2171 dbSNP
rs908248998 2172 dbSNP
rs1436217690 2174 dbSNP
rs939692619 2175 dbSNP
rs1038075279 2186 dbSNP
rs573018143 2191 dbSNP
rs532095061 2197 dbSNP
rs1379807121 2213 dbSNP
rs184016982 2218 dbSNP
rs1440182376 2222 dbSNP
rs898161229 2226 dbSNP
rs1008196001 2227 dbSNP
rs1454261724 2228 dbSNP
rs1018726441 2245 dbSNP
rs752084219 2248 dbSNP
rs1055372770 2249 dbSNP
rs896669920 2254 dbSNP
rs1157568074 2255 dbSNP
rs1284633119 2262 dbSNP
rs1240262447 2265 dbSNP
rs763010273 2272 dbSNP
rs1218996311 2274 dbSNP
rs1385996719 2279 dbSNP
rs1458319479 2281 dbSNP
rs1013714783 2286 dbSNP
rs1398340645 2290 dbSNP
rs1360157760 2293 dbSNP
rs979953312 2294 dbSNP
rs925403729 2297 dbSNP
rs1370126126 2303 dbSNP
rs552271079 2306 dbSNP
rs371425764 2310 dbSNP
rs755577215 2312 dbSNP
rs542242212 2319 dbSNP
rs988309028 2322 dbSNP
rs918138254 2325 dbSNP
rs902630754 2330 dbSNP
rs1487073862 2331 dbSNP
rs1001355119 2332 dbSNP
rs1287921011 2337 dbSNP
rs1032366230 2346 dbSNP
rs949648227 2347 dbSNP
rs1045398133 2363 dbSNP
rs926977423 2364 dbSNP
rs964667286 2365 dbSNP
rs937095963 2368 dbSNP
rs1217197438 2380 dbSNP
rs6457782 2381 dbSNP
rs1028171169 2382 dbSNP
rs531190904 2383 dbSNP
rs1409248248 2384 dbSNP
rs986618493 2385 dbSNP
rs1359691237 2386 dbSNP
rs1178246513 2392 dbSNP
rs908367194 2397 dbSNP
rs1159218596 2403 dbSNP
rs1393181360 2406 dbSNP
rs1478500207 2407 dbSNP
rs1253417640 2409 dbSNP
rs961193281 2412 dbSNP
rs546498021 2413 dbSNP
rs1391402541 2427 dbSNP
rs1197140553 2430 dbSNP
rs1390556242 2431 dbSNP
rs564488337 2437 dbSNP
rs1220733604 2440 dbSNP
rs1306010940 2448 dbSNP
rs149024306 2452 dbSNP
rs1018262108 2460 dbSNP
rs1396687105 2461 dbSNP
rs1230541085 2467 dbSNP
rs1289056000 2468 dbSNP
rs1055386856 2469 dbSNP
rs918138391 2470 dbSNP
rs949660876 2474 dbSNP
rs1267709757 2475 dbSNP
rs756279628 2478 dbSNP
rs1489104485 2480 dbSNP
rs899801793 2489 dbSNP
rs927173138 2493 dbSNP
rs1042599830 2499 dbSNP
rs1245495088 2500 dbSNP
rs1250112651 2501 dbSNP
rs902659774 2503 dbSNP
rs568975270 2504 dbSNP
rs1053768136 2507 dbSNP
rs879895826 2508 dbSNP
rs970983555 2510 dbSNP
rs900526586 2511 dbSNP
rs1245599352 2517 dbSNP
rs1199379161 2518 dbSNP
rs996095930 2519 dbSNP
rs1028205619 2523 dbSNP
rs34471710 2523 dbSNP
rs143190690 2546 dbSNP
rs955354120 2547 dbSNP
rs1331723599 2554 dbSNP
rs1461457896 2555 dbSNP
rs777840731 2559 dbSNP
rs1305952162 2563 dbSNP
rs1015451407 2564 dbSNP
rs1162342170 2572 dbSNP
rs1410227018 2577 dbSNP
rs936981134 2589 dbSNP
rs1308799323 2593 dbSNP
rs1156333387 2597 dbSNP
rs1439564680 2601 dbSNP
rs1381487026 2628 dbSNP
rs751921268 2635 dbSNP
rs755732503 2635 dbSNP
rs973768980 2635 dbSNP
rs1378754125 2639 dbSNP
rs1394311360 2652 dbSNP
rs1210708740 2663 dbSNP
rs1490911927 2667 dbSNP
rs1283913410 2668 dbSNP
rs1239537615 2677 dbSNP
rs568142873 2682 dbSNP
rs961490250 2687 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgucggucgaGAUGGGGGCGGu 5'
                    ||: |||: || 
Target 5' ---------cCUGACCCUUCCa 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000244458.2 | 3UTR | CCUGACCCUUCCACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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