| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-5189 |
| Genomic Coordinates | chr16: 88468918 - 88469031 |
| Description | Homo sapiens miR-5189 stem-loop |
| Comment | None |
| RNA Secondary Structure |  |
| Mature miRNA Information | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mature miRNA | hsa-miR-5189-5p | ||||||||||||||||||||||||
| Sequence | 26| UCUGGGCACAGGCGGAUGGACAGG |49 | ||||||||||||||||||||||||
| Evidence | Experimental | ||||||||||||||||||||||||
| Experiments | Illumina | ||||||||||||||||||||||||
| SNPs in miRNA |
|
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| Putative Targets | |||||||||||||||||||||||||
| miRNA Expression profile | |
|---|---|
| Human miRNA Tissue Atlas | |
| Circulating MicroRNA Expression Profiling | |
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | ZBTB34 | ||||||||||||||||||||
| Synonyms | ZNF918 | ||||||||||||||||||||
| Description | zinc finger and BTB domain containing 34 | ||||||||||||||||||||
| Transcript | NM_001099270 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on ZBTB34 | |||||||||||||||||||||
| 3'UTR of ZBTB34 (miRNA target sites are highlighted) |
>ZBTB34|NM_001099270|3'UTR 1 GATGGTAAAGAAGTGCACCCAAACAAAGCACATTAATCAATGCATATTTGTGATTTGCTTTGTTGTAATCTTTGGTTTTC 81 CCAACCATCTGGAAATCTCTTGGTCTCTTGGCAGTTTTTCTAAAGTTTCTGGATGGAACACTTCGTTGTGTTTATCCTTT 161 CCCCTGCCCTCCCTCCCCGAAGGAGCTCAAAGCATGAAGGGCAACGCATCCAGGGAAAACACAGGCTGACAGTATTCCTC 241 TTTGGCTGAACTCTTAATCCAAAATCTGCCAGTGATTTAGCTATGCCAACTGGTTGACCCTCCATTCTCTGCCAAGAGGC 321 ATACTCTTTCTCATTGTGTGCGCTGGCAGCAGTGCACTTCCACGGAGGGAGATTAGGATGCCGTCAGCTGATACAAATGG 401 GTAACCTTTTCTAATTTAAAATTCCTTTTAGGGGGTAGTTAGACAATTTATATATATATATAATAAAACTATTATTATAT 481 ATATAGTATATATACATTTTCAAATTTGATTTTATTCTGGTTGAGGTGAATGTAAGAGGAATATATAATTTAATACAATG 561 TGAACAGGGCTTCTGAGTCTATCTCATCCCTACCTAATATGTTAGGGTTTTGCCCCTTCATTTCCCTTACAAAAGAATGT 641 TAGTAGGTTTATATTAATCATTGTGTCCAAAAGCAAGCAAAGCAAATCACAGTGTTCACAGCTCTGCTTCATAACAAATA 721 CATAAACCAAATGCCATAAAATTTCTTCAACTCTAGTTGGAAACCGTTTGGAATTTTTGTTAGTTGTCCAGCAGGTAAGC 801 TGGATGACCTGTGGTGCTGACCTTTTTACATAGTGTAGTGTTATATTAGCCAACCCCAAAGGAGCAGTGGTTTTCAAGGT 881 TTTTACTGGCCTACAAATCTACCTTCATTCCGTACTGTAGAAACATACATACCAGGTAACTAAATCGAATCACTCTCTAT 961 CATGAGTTAGTACTCACTCGCACTTAAGGAAAGGGATTTGTAGTTCTGTCTACAAAATTCTCCAAGCAGTGTTGTGGTTT 1041 TTTTTGTTTTTGTTTTTTTTCTTTCTCTTTTCAAACAGCCAGTTCAGGTGCACAGCAACTTTTTCTACATGCAGTTCCCA 1121 GGGAAACTGCAGAACTTAGAATTTGTACTTTTTGTAAAGCTATACTCTATGGGAATTGCAAGCAATATATCTATCTTAGT 1201 ATTGTGTGTGCTAATGAGAGCCTCAGTGGCTCCCCCACTCTCTCAGTGTTTCCTGCTTAAAGAACCAACAGTTTAAAAGC 1281 CCTCTAAGATACTCTGTGTGTCACCAAATCTGTGTGTCACCATTTTTTGGTCATGTGGTGCTATTTTTGTTAAGTGTCTT 1361 TTTAGGTCAGTATAGTTGTAGAAAATGTGAAATCTGATGGTAATAATGAATTATAATTGTTTTCCTCTCTTGAGTTCATA 1441 GCTTGAAAAGAGACCTCAAAAGCATGTGCTGGCAAACACGTTACTGTATGAAAACATACCTGAGTCCATTTGAATAATGT 1521 TTTATTAGTACTTTCGGAAATGTCTTCAGTTCTGTATTGTGTTCACATACACAAACAGGCTTTACAAGATTGCTTCGGTA 1601 CTGTAAACTCTGGCAGAGAGTAATTTTGTAGGCAGTTTGGTGGTGAGTTTGTGCTGCAGGCTGCCTGTGGGATGTCAGCG 1681 TTCTGGTATCTGCCTGAGAACCTGGGCTCTGAGACGCACAACCAGTGCACCTCCATAGGAGAACAGTGCAGCCACCTAAA 1761 AGAAAAACGAACGAAGGACCAGCCTCAGAGGCTAGAAGTTAAAGGAATACAGAATTAGATGTTTGCTGGTTTTCTGTGCT 1841 TTTTTGGCTCCTAAAATACCAATGGTGGATTTGTTTTTGTTTTTGTTTTTTGTTTTGAGAAATAAAAAGTCATTCAAGCC 1921 CTTTGTGTGTAATAGCCCCCAGGGGTGGCAGCTGTGCAGTCGCATCTCTTTGGCACACAGGATCTGTTCACGTGTGAACT 2001 GCTGCGCTACACATCAGTGTTAACTCCCTACAGATTACACTCTAATCCCGCTGCTCCCGAGGAGCGGCTTTGCTAAATCG 2081 GGTATATAGTATATGCCTTTTTCCTCGTCAAACTGCCTAAGTAGGGGTTCGTTCTCTCCCTGAAGCACTTGTTCAACTCC 2161 TGTTAAAGCCGCGTGCCTCAAGGGGAGGCTGGACCCCAAGTGTTTACCCACTTAAATATGTTCTGGGGTTTCAGGTAAAT 2241 GTTTGTGGGTTTTTTTTTCCTTACATGAATAAGTTTGGTTTTGATTTTTTTTTAATTGAATGCAAAAAATTTGTGTTGTG 2321 ATACAAATTAAGTTTGTGACAAGAAATGCCCAAATCCAAGGACATAAGAGGTCAAGCTCAGGGAAGGAACCTCCTTTTCA 2401 CTCAGGCTTGGGGCCTCCAGCGAGGTTTCCAGAGCATTCCATGGTATGAGAGACAGTGAGGAGGGAGGGCACCTGGCGCG 2481 GGCACTTCCAGCGTCCTGGCTCTTGGCATTGTCCGTCTTAACCTTATTTACATGGAGTTCTTTGTATTTGTGAATCTGTT 2561 TAACTGGTTTGAGTTTACCAAAGAGTGACTTATCCAAAATTGTCTTTGACAAAAATATCCATTGCTTTGATTGTACAGTT 2641 CAGGTTCAAACATTGTAATGGGACTGTTAAGGGGCAGAAAATTGATTGAGTTTCTCTCTAAGAATCATGATTCCACATTT 2721 TGCAAGTTCCACTTGCTCCCATTCGTGTTGCTAACACTTTACCCTTTCCACTGCTCGCAGTGTTAAGAATGAATTCTCAA 2801 GCCATAACACAGTACTGTAAAGTTCCGCAGGGCTTCGAGGGAGGCAGCGCCTAGGCCAGCACGGAGCTGTGTAGCCTCTC 2881 TGAGCGTTCGCACTGTCATGCTTCCCAGGGGTGTGACTGGTGAGAGATTAACTCCATTCAGATCGGGCAGCAGCAATTAA 2961 TTGTGCCTTGCCGCATGAGGATGTGTCAGGAGGATTAACATGACCACAGAACCGAAACATTCTCTCCCTGAAGTTCACTT 3041 CACGTCTCCGCAGACGAAGTACGCTGTGTAACTCCTTAGAGCAACTCTTTTTGGAAAGCAAAGTCCCTATTTCTGTACAG 3121 TTTTAGGTTAGGTGTTTCATTTATAACAGATGCAGAAATCAATTAAGATAAAGTGATATGTGAAGAAATCTTTTACAGTA 3201 AAATATATCCTGAATTCATATAGGCTTGTTCATAATTGAGTCTCTTCTTGAGCTACCTTTTCAATATTAGACAATGTGAA 3281 GACAGTGACAGCGTCCTTTTCTAGAGATATTTAGCCTGTTATTACAAACTGTGAAGACAAAGAATTTTATACTTTTACTA 3361 ATGTTTGTGGTTTTAAACAGTTATTTTCATTCTAATCAGTTCTCTACCCTCTAATTTCTACTAAAGCTGTAAATACATTT 3441 AGAAATTATATTTGTAAATACAGTATATGGAGACAAGTTAATTTTTTGGTCAGTGGAAAAAGCCTCCCAACCAATTGGCC 3521 CTGCCTTGGCAGTTGTGTTTTTTGTTGTTGTTGTTGTTGTTTTAGTTTAGTTTTTTTTTTTAAACAGCAGAAAGGATACT 3601 GTCGGTTCACTGTTGAGCAGAATATACTGTAGAACGAAAATGATAATTTTTAAATCTTCCAGAGCATGAGTAAATGTCTT 3681 TTCTAATGATAGCAAATATAACCAACTCTTTGTTTTTCCCTTAGCCCAGACCATATAGACCTGCGTATTTTGTGTGTGGT 3761 TTTGTTTTTATTTTTGTTCTTACAGCCTAGACCCTAGGAAAAATTTGCAGGAACACGAAACAAGGGCTGGGGGGAAAATC 3841 ATCTATGTGAATGAGCTTTACTTTAAAGAGATCAATGTATTTTATTTTATCAACTTTTTCTCTTAGTTACTGTGATTTTT 3921 GTTGTTGTTGTCCTCGTTATTGTTAAATTCTGTAATGGTTTCCTGTGAAGCCTCCACTGAAAGGGACTCAAATATGCAAC 4001 ACCTAAACTATTTTCCAAGGGCACATGCCCCTTGAATGGTGCTTCTAGACTGGTCAGGGTTATTTATTAAATTTTATATA 4081 TGAAAGTATTGGGGAATTATGTAAATTCTTTATATGAAACTATCTAGTTCATAAATCATAGATTTCATATTACTCAGTGC 4161 AACTGAACTAAAAGTTCAGAAAAGTCATTCACATTGTTCCAAATTTGTAATGGTTGTCACATGTCACATGCGTCTTTTTC 4241 AGTAAGTGCCAGAGTGTTCCCACTGTTTCTGCCCAGTGCTTGACTTCTCGGCCCGGAAGAGAACCTGCTTTCTCTGGTTT 4321 CCTTCCTGAGTCTGGCACAGACGGGGCTATTGTAGTTCTTGATCAAGTCCTGGAGTCAGCCTTGCCTGGCTCTCCTTGTA 4401 GCAGATTCAGTCCACAGACCTCTTGCTGCCCCTCAGTGACAAGTATGCTGTGAATTCAACCTTTGGACTTGCTGCCCAAG 4481 CCTTTGGTTGCTGCCCTGACTATTGTAAGAGGTAAACTTACCTGGTTTGTTTGAGAATGACCATTTTCCTAATGTGAAAA 4561 CCATCTCTCTCACCACTTTTATTAGTAGGGCTAACATTTTTTTCCGTTATAAATGGTTGAGCAATTTGAATGACTTAACA 4641 CAGTGTCATTATCTTGCAATATAAACTGGTAACCTCACAACTCCACACTTCATCACCATATGAAGTAAATGAAGCTAGCT 4721 AAGCGGATGCTGTATCAACTAGTAACTTGCCATTAAGGATTATTTTATAGCATGAATTTAAGACTATTTATTCAAATGAT 4801 ATTTTACTCTTGTATTCACTTTGTTTTAGATTTGTGACATGAATATTTCAGTGCTGCTTAATTTTGTTCTGAATTCTTGT 4881 TTCTTGCTTGTAAATGGCTTTTTTATGGTATAAATAAAGTCAATGGACATTGCTGTTTGTAAATAAAAATGCTGCTAGAG 4961 CAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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| miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
|---|---|---|---|---|---|---|---|
| miRNA:Target | ---- | ||||||
| Validation Method |
|
||||||
| Conditions | HEK293 | ||||||
| Location of target site | 3'UTR | ||||||
| Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
||||||
| miRNA-target interactions (Provided by authors) |
|
||||||
| Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
||||||
| Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
|---|---|---|---|---|---|---|---|
| miRNA:Target | ---- | ||||||
| Validation Method |
|
||||||
| Conditions | hESCs (WA-09) | ||||||
| Disease | 403341.0 | ||||||
| Location of target site | 3'UTR | ||||||
| Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
| Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
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| miRNA-target interactions (Provided by authors) |
|
||||||
| Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
|
||||||
| Experimental Support 3 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | C8166 , TZM-bl |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3
PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL
... - Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio. |
| Article |
- Whisnant AW; Bogerd HP; Flores O; Ho P; et al. - mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
|
| Experimental Support 4 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | Prostate Tissue |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in SRX1760591. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_B
PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C
PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A
PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A
PAR-CLIP data was present in SRX1760641. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_B
... - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.). |
| Article |
- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al. - Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
|
| CLIP-seq Support 1 for dataset GSM545215 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO4 |
| Cell line / Condition | HEK293 / Control |
| Location of target site | ENST00000319119.4 | 3UTR | GUUUCUGCCCAGUGCUUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 2 for dataset SRR359787 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
| Location of target site | ENST00000319119.4 | 3UTR | UGUUUCUGCCCAGUGCUUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 22012620 / SRX103431 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 3 for dataset GSM1462572 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | C8166 / C8166 NL4-3 |
| Location of target site | ENST00000319119.4 | 3UTR | UUUCUGCCCAGUGCUUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 23592263 / GSE59944 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 4 for dataset GSM1462573 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | TZM-bl / TZM-bl BaL |
| Location of target site | ENST00000319119.4 | 3UTR | UUUCUGCCCAGUGCUUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 23592263 / GSE59944 |
| CLIP-seq Viewer | Link |
| MiRNA-Target Expression Profile | |||||||
|---|---|---|---|---|---|---|---|
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| MiRNA-Target Expression Profile (TCGA) | |||||||
|---|---|---|---|---|---|---|---|
|
177 hsa-miR-5189-5p Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT142280 | DCTN5 | dynactin subunit 5 |  |
|
2 | 4 | ||||||
| MIRT455613 | SRSF3 | serine and arginine rich splicing factor 3 | |
|
2 | 2 | ||||||
| MIRT458687 | MRI1 | methylthioribose-1-phosphate isomerase 1 | |
|
2 | 2 | ||||||
| MIRT470847 | PLXND1 | plexin D1 | |
|
2 | 2 | ||||||
| MIRT471838 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | |
|
2 | 2 | ||||||
| MIRT475228 | IKZF3 | IKAROS family zinc finger 3 | |
|
2 | 4 | ||||||
| MIRT480294 | C7orf73 | short transmembrane mitochondrial protein 1 | |
|
2 | 4 | ||||||
| MIRT483509 | C10orf76 | chromosome 10 open reading frame 76 | |
|
2 | 2 | ||||||
| MIRT484952 | ZBTB34 | zinc finger and BTB domain containing 34 | |
|
2 | 6 | ||||||
| MIRT489295 | B4GALNT4 | beta-1,4-N-acetyl-galactosaminyltransferase 4 | |
|
2 | 4 | ||||||
| MIRT490801 | PSMD3 | proteasome 26S subunit, non-ATPase 3 | |
|
2 | 2 | ||||||
| MIRT493375 | KIAA1614 | KIAA1614 | |
|
2 | 2 | ||||||
| MIRT496408 | PARVB | parvin beta | |
|
2 | 2 | ||||||
| MIRT497267 | GRK6 | G protein-coupled receptor kinase 6 | |
|
2 | 2 | ||||||
| MIRT497679 | SYNGR1 | synaptogyrin 1 | |
|
2 | 2 | ||||||
| MIRT498222 | TLN2 | talin 2 | |
|
2 | 2 | ||||||
| MIRT498313 | BCL11B | B-cell CLL/lymphoma 11B | |
|
2 | 2 | ||||||
| MIRT504049 | TOMM5 | translocase of outer mitochondrial membrane 5 | |
|
2 | 2 | ||||||
| MIRT516313 | F8A2 | coagulation factor VIII associated 2 | |
|
2 | 2 | ||||||
| MIRT516339 | F8A3 | coagulation factor VIII associated 3 | |
|
2 | 2 | ||||||
| MIRT517813 | UGDH | UDP-glucose 6-dehydrogenase | |
|
2 | 6 | ||||||
| MIRT518743 | C1orf35 | chromosome 1 open reading frame 35 | |
|
2 | 2 | ||||||
| MIRT519295 | MLH1 | mutL homolog 1 | |
|
2 | 2 | ||||||
| MIRT520387 | UBB | ubiquitin B | |
|
2 | 4 | ||||||
| MIRT525228 | DPY19L3 | dpy-19 like C-mannosyltransferase 3 | |
|
2 | 2 | ||||||
| MIRT533147 | WNT10A | Wnt family member 10A | |
|
2 | 2 | ||||||
| MIRT533544 | TPR | translocated promoter region, nuclear basket protein | |
|
2 | 2 | ||||||
| MIRT533684 | TMEM86A | transmembrane protein 86A | |
|
2 | 2 | ||||||
| MIRT534544 | RUNX1 | runt related transcription factor 1 | |
|
2 | 2 | ||||||
| MIRT539592 | SSH2 | slingshot protein phosphatase 2 | |
|
2 | 2 | ||||||
| MIRT539676 | ZBTB44 | zinc finger and BTB domain containing 44 | |
|
2 | 2 | ||||||
| MIRT539710 | EIF3H | eukaryotic translation initiation factor 3 subunit H | |
|
2 | 2 | ||||||
| MIRT539730 | DNAH10OS | dynein axonemal heavy chain 10 opposite strand | |
|
2 | 2 | ||||||
| MIRT539755 | CNBP | CCHC-type zinc finger nucleic acid binding protein | |
|
2 | 2 | ||||||
| MIRT539787 | EMC1 | ER membrane protein complex subunit 1 | |
|
2 | 4 | ||||||
| MIRT539812 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | |
|
2 | 2 | ||||||
| MIRT539995 | SLC24A4 | solute carrier family 24 member 4 | |
|
2 | 2 | ||||||
| MIRT540073 | SSH3 | slingshot protein phosphatase 3 | |
|
2 | 2 | ||||||
| MIRT540092 | NPY4R | neuropeptide Y receptor Y4 | |
|
2 | 2 | ||||||
| MIRT540428 | FAM83F | family with sequence similarity 83 member F | |
|
2 | 2 | ||||||
| MIRT540512 | CXCL10 | C-X-C motif chemokine ligand 10 | |
|
2 | 2 | ||||||
| MIRT540531 | ZNF417 | zinc finger protein 417 | |
|
2 | 2 | ||||||
| MIRT540622 | F2RL2 | coagulation factor II thrombin receptor like 2 | |
|
2 | 2 | ||||||
| MIRT540909 | PON1 | paraoxonase 1 | |
|
2 | 2 | ||||||
| MIRT540990 | ZNF460 | zinc finger protein 460 | |
|
2 | 4 | ||||||
| MIRT541513 | TOR1AIP1 | torsin 1A interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT541633 | PARP2 | poly(ADP-ribose) polymerase 2 | |
|
2 | 2 | ||||||
| MIRT541665 | ATP8B3 | ATPase phospholipid transporting 8B3 | |
|
2 | 2 | ||||||
| MIRT541738 | ZC3HAV1 | zinc finger CCCH-type containing, antiviral 1 | |
|
2 | 2 | ||||||
| MIRT541813 | SMU1 | DNA replication regulator and spliceosomal factor | |
|
2 | 2 | ||||||
| MIRT541904 | VWA7 | von Willebrand factor A domain containing 7 | |
|
2 | 2 | ||||||
| MIRT542004 | XRCC2 | X-ray repair cross complementing 2 | |
|
2 | 2 | ||||||
| MIRT542020 | PEX2 | peroxisomal biogenesis factor 2 | |
|
2 | 2 | ||||||
| MIRT542187 | FUT1 | fucosyltransferase 1 (H blood group) | |
|
2 | 6 | ||||||
| MIRT542204 | C14orf142 | GON7, KEOPS complex subunit homolog | |
|
2 | 2 | ||||||
| MIRT542337 | LIMD1 | LIM domains containing 1 | |
|
2 | 2 | ||||||
| MIRT542426 | ZNF331 | zinc finger protein 331 | |
|
2 | 2 | ||||||
| MIRT542459 | AKR7A2 | aldo-keto reductase family 7 member A2 | |
|
2 | 2 | ||||||
| MIRT542494 | WDR13 | WD repeat domain 13 | |
|
2 | 2 | ||||||
| MIRT542552 | MRPS10 | mitochondrial ribosomal protein S10 | |
|
2 | 2 | ||||||
| MIRT542699 | RPS15A | ribosomal protein S15a | |
|
2 | 2 | ||||||
| MIRT542819 | PDE12 | phosphodiesterase 12 | |
|
2 | 2 | ||||||
| MIRT552108 | PPP1R1A | protein phosphatase 1 regulatory inhibitor subunit 1A | |
|
2 | 2 | ||||||
| MIRT555606 | PIK3R1 | phosphoinositide-3-kinase regulatory subunit 1 | |
|
2 | 2 | ||||||
| MIRT564916 | YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | |
|
2 | 2 | ||||||
| MIRT568609 | ACVR2A | activin A receptor type 2A | |
|
2 | 2 | ||||||
| MIRT608702 | GMPR | guanosine monophosphate reductase | |
|
2 | 2 | ||||||
| MIRT610061 | MYBPC1 | myosin binding protein C, slow type | |
|
2 | 2 | ||||||
| MIRT610794 | KLK2 | kallikrein related peptidase 2 | |
|
2 | 2 | ||||||
| MIRT617179 | GOSR2 | golgi SNAP receptor complex member 2 | |
|
2 | 2 | ||||||
| MIRT620581 | WBSCR27 | methyltransferase like 27 | |
|
2 | 4 | ||||||
| MIRT623348 | MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | |
|
2 | 2 | ||||||
| MIRT623873 | FUS | FUS RNA binding protein | |
|
2 | 2 | ||||||
| MIRT625418 | IMP4 | IMP4, U3 small nucleolar ribonucleoprotein | |
|
2 | 2 | ||||||
| MIRT630227 | SORD | sorbitol dehydrogenase | |
|
2 | 2 | ||||||
| MIRT631870 | BBS5 | Bardet-Biedl syndrome 5 | |
|
2 | 2 | ||||||
| MIRT631905 | VEGFC | vascular endothelial growth factor C | |
|
2 | 2 | ||||||
| MIRT632005 | POPDC2 | popeye domain containing 2 | |
|
2 | 2 | ||||||
| MIRT632876 | GOSR1 | golgi SNAP receptor complex member 1 | |
|
2 | 2 | ||||||
| MIRT633313 | LINC00346 | long intergenic non-protein coding RNA 346 | |
|
2 | 2 | ||||||
| MIRT633989 | SLC35E2 | solute carrier family 35 member E2 | |
|
2 | 2 | ||||||
| MIRT635248 | ELOVL6 | ELOVL fatty acid elongase 6 | |
|
2 | 2 | ||||||
| MIRT635258 | FBXL20 | F-box and leucine rich repeat protein 20 | |
|
2 | 2 | ||||||
| MIRT635280 | GK5 | glycerol kinase 5 (putative) | |
|
2 | 2 | ||||||
| MIRT635862 | SLC11A2 | solute carrier family 11 member 2 | |
|
2 | 2 | ||||||
| MIRT636624 | CHAF1B | chromatin assembly factor 1 subunit B | |
|
2 | 4 | ||||||
| MIRT637085 | SELPLG | selectin P ligand | |
|
2 | 2 | ||||||
| MIRT639025 | AAK1 | AP2 associated kinase 1 | |
|
2 | 2 | ||||||
| MIRT640876 | ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | |
|
2 | 2 | ||||||
| MIRT641928 | SLC25A16 | solute carrier family 25 member 16 | |
|
2 | 2 | ||||||
| MIRT642173 | HEBP2 | heme binding protein 2 | |
|
2 | 2 | ||||||
| MIRT642251 | PAK4 | p21 (RAC1) activated kinase 4 | |
|
2 | 2 | ||||||
| MIRT642854 | RNF135 | ring finger protein 135 | |
|
2 | 2 | ||||||
| MIRT643240 | PRSS21 | protease, serine 21 | |
|
2 | 2 | ||||||
| MIRT643375 | TRIM16L | tripartite motif containing 16 like | |
|
2 | 2 | ||||||
| MIRT646931 | MCCC2 | methylcrotonoyl-CoA carboxylase 2 | |
|
2 | 2 | ||||||
| MIRT647803 | FRMD8 | FERM domain containing 8 | |
|
2 | 2 | ||||||
| MIRT650517 | UFM1 | ubiquitin fold modifier 1 | |
|
2 | 2 | ||||||
| MIRT651618 | WASF3 | WAS protein family member 3 | |
|
2 | 2 | ||||||
| MIRT655588 | OTUD7B | OTU deubiquitinase 7B | |
|
2 | 2 | ||||||
| MIRT657652 | GPR75 | G protein-coupled receptor 75 | |
|
2 | 2 | ||||||
| MIRT657835 | GJD3 | gap junction protein delta 3 | |
|
2 | 2 | ||||||
| MIRT658357 | FAM65B | RHO family interacting cell polarization regulator 2 | |
|
2 | 2 | ||||||
| MIRT661173 | S1PR2 | sphingosine-1-phosphate receptor 2 | |
|
2 | 2 | ||||||
| MIRT661332 | TBC1D15 | TBC1 domain family member 15 | |
|
2 | 2 | ||||||
| MIRT662003 | ZNF445 | zinc finger protein 445 | |
|
2 | 2 | ||||||
| MIRT662194 | MEI1 | meiotic double-stranded break formation protein 1 | |
|
2 | 2 | ||||||
| MIRT663473 | POFUT2 | protein O-fucosyltransferase 2 | |
|
2 | 2 | ||||||
| MIRT663958 | ZNF554 | zinc finger protein 554 | |
|
2 | 2 | ||||||
| MIRT665907 | TBCCD1 | TBCC domain containing 1 | |
|
2 | 2 | ||||||
| MIRT666029 | STRN3 | striatin 3 | |
|
2 | 2 | ||||||
| MIRT666496 | SBNO1 | strawberry notch homolog 1 | |
|
2 | 2 | ||||||
| MIRT667290 | MYPN | myopalladin | |
|
2 | 4 | ||||||
| MIRT668020 | HAUS3 | HAUS augmin like complex subunit 3 | |
|
2 | 2 | ||||||
| MIRT670087 | ABCF3 | ATP binding cassette subfamily F member 3 | |
|
2 | 4 | ||||||
| MIRT670598 | LLGL1 | LLGL1, scribble cell polarity complex component | |
|
2 | 4 | ||||||
| MIRT670689 | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | |
|
2 | 2 | ||||||
| MIRT670848 | SFT2D2 | SFT2 domain containing 2 | |
|
2 | 2 | ||||||
| MIRT670981 | MED17 | mediator complex subunit 17 | |
|
2 | 2 | ||||||
| MIRT672621 | IGF2R | insulin like growth factor 2 receptor | |
|
2 | 2 | ||||||
| MIRT673223 | KLHDC8A | kelch domain containing 8A | |
|
2 | 2 | ||||||
| MIRT674265 | ZNF284 | zinc finger protein 284 | |
|
2 | 2 | ||||||
| MIRT675631 | HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | |
|
2 | 2 | ||||||
| MIRT675806 | MED28 | mediator complex subunit 28 | |
|
2 | 2 | ||||||
| MIRT676337 | PCCB | propionyl-CoA carboxylase beta subunit | |
|
2 | 2 | ||||||
| MIRT681724 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 | |
|
2 | 2 | ||||||
| MIRT682844 | DNAJC28 | DnaJ heat shock protein family (Hsp40) member C28 | |
|
2 | 2 | ||||||
| MIRT682913 | FAM73A | mitoguardin 1 | |
|
2 | 2 | ||||||
| MIRT682932 | ZNF292 | zinc finger protein 292 | |
|
2 | 2 | ||||||
| MIRT682950 | RPL12 | ribosomal protein L12 | |
|
2 | 2 | ||||||
| MIRT683030 | SUSD5 | sushi domain containing 5 | |
|
2 | 2 | ||||||
| MIRT684387 | MCTS1 | MCTS1, re-initiation and release factor | |
|
2 | 2 | ||||||
| MIRT684687 | OR7D2 | olfactory receptor family 7 subfamily D member 2 | |
|
2 | 2 | ||||||
| MIRT687202 | PLXNA3 | plexin A3 | |
|
2 | 2 | ||||||
| MIRT689145 | IRAK1BP1 | interleukin 1 receptor associated kinase 1 binding protein 1 | |
|
2 | 2 | ||||||
| MIRT689632 | NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit | |
|
2 | 2 | ||||||
| MIRT690598 | C17orf105 | chromosome 17 open reading frame 105 | |
|
2 | 2 | ||||||
| MIRT690802 | FAHD1 | fumarylacetoacetate hydrolase domain containing 1 | |
|
2 | 2 | ||||||
| MIRT690943 | GLG1 | golgi glycoprotein 1 | |
|
2 | 2 | ||||||
| MIRT691850 | OSCAR | osteoclast associated, immunoglobulin-like receptor | |
|
2 | 2 | ||||||
| MIRT693615 | CENPL | centromere protein L | |
|
2 | 2 | ||||||
| MIRT693757 | ZNF383 | zinc finger protein 383 | |
|
2 | 2 | ||||||
| MIRT694014 | PPIL4 | peptidylprolyl isomerase like 4 | |
|
2 | 2 | ||||||
| MIRT694594 | AAR2 | AAR2 splicing factor homolog | |
|
2 | 2 | ||||||
| MIRT694983 | PLAC8 | placenta specific 8 | |
|
2 | 2 | ||||||
| MIRT695016 | MRPS21 | mitochondrial ribosomal protein S21 | |
|
2 | 2 | ||||||
| MIRT696414 | DOCK7 | dedicator of cytokinesis 7 | |
|
2 | 2 | ||||||
| MIRT697803 | UBXN2A | UBX domain protein 2A | |
|
2 | 2 | ||||||
| MIRT697941 | TVP23C | trans-golgi network vesicle protein 23 homolog C | |
|
2 | 2 | ||||||
| MIRT698775 | STK4 | serine/threonine kinase 4 | |
|
2 | 2 | ||||||
| MIRT699532 | SIX4 | SIX homeobox 4 | |
|
2 | 2 | ||||||
| MIRT701073 | PARD6B | par-6 family cell polarity regulator beta | |
|
2 | 2 | ||||||
| MIRT702610 | ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein like 2 | |
|
2 | 2 | ||||||
| MIRT702688 | IRGQ | immunity related GTPase Q | |
|
2 | 2 | ||||||
| MIRT702931 | HMX3 | H6 family homeobox 3 | |
|
2 | 2 | ||||||
| MIRT703721 | FAM127A | retrotransposon Gag like 8C | |
|
2 | 2 | ||||||
| MIRT704296 | DDX19B | DEAD-box helicase 19B | |
|
2 | 2 | ||||||
| MIRT704332 | DCTN6 | dynactin subunit 6 | |
|
2 | 2 | ||||||
| MIRT706758 | KIAA0907 | KIAA0907 | |
|
2 | 2 | ||||||
| MIRT708483 | OLR1 | oxidized low density lipoprotein receptor 1 | |
|
2 | 2 | ||||||
| MIRT710773 | PHF7 | PHD finger protein 7 | |
|
2 | 2 | ||||||
| MIRT712484 | FSTL3 | follistatin like 3 | |
|
2 | 2 | ||||||
| MIRT712784 | ZNF154 | zinc finger protein 154 | |
|
2 | 2 | ||||||
| MIRT714507 | SHE | Src homology 2 domain containing E | |
|
2 | 2 | ||||||
| MIRT714771 | TERF1 | telomeric repeat binding factor 1 | |
|
2 | 2 | ||||||
| MIRT715263 | RNF125 | ring finger protein 125 | |
|
2 | 2 | ||||||
| MIRT716447 | TMPRSS11BNL | TMPRSS11B N-terminal like, pseudogene | |
|
2 | 2 | ||||||
| MIRT718198 | PSMF1 | proteasome inhibitor subunit 1 | |
|
2 | 2 | ||||||
| MIRT720001 | SNRPD3 | small nuclear ribonucleoprotein D3 polypeptide | |
|
2 | 2 | ||||||
| MIRT720394 | ZNF549 | zinc finger protein 549 | |
|
2 | 2 | ||||||
| MIRT720597 | TTC39C | tetratricopeptide repeat domain 39C | |
|
2 | 2 | ||||||
| MIRT721231 | CRCP | CGRP receptor component | |
|
2 | 2 | ||||||
| MIRT721261 | SH3D19 | SH3 domain containing 19 | |
|
2 | 2 | ||||||
| MIRT721802 | GRM1 | glutamate metabotropic receptor 1 | |
|
2 | 2 | ||||||
| MIRT722573 | C1orf95 | stum, mechanosensory transduction mediator homolog | |
|
2 | 2 | ||||||
| MIRT722842 | C17orf102 | chromosome 17 open reading frame 102 | |
|
2 | 2 | ||||||
| MIRT722909 | COA4 | cytochrome c oxidase assembly factor 4 homolog | |
|
2 | 2 | ||||||
| miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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