miRTarBase - #MIRT486530


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pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-5p
Sequence 3| UGCGGGGACAGGCCAGGGCAUC |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN13820895 3 COSMIC
COSN23388686 4 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs770355657 2 dbSNP
rs370929811 3 dbSNP
rs552910419 4 dbSNP
rs766523467 7 dbSNP
rs751761421 13 dbSNP
rs759326327 15 dbSNP
rs747312801 19 dbSNP
rs1336524397 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CLCN7   
Synonyms CLC-7, CLC7, OPTA2, OPTB4, PPP1R63
Description chloride voltage-gated channel 7
Transcript NM_001114331   
Other Transcripts NM_001287   
Expression
Putative miRNA Targets on CLCN7
3'UTR of CLCN7
(miRNA target sites are highlighted)		 
>CLCN7|NM_001114331|3'UTR
   1 GGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCG
  81 GCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCC
 161 TCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCAGCCTCCACTCTCCTC
 241 GTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGCCAGCG
 321 GCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCT
 401 GCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGA
 481 GCAGACGGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCA
 561 GCTTCACACTGGCGCCACAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACT
 641 GGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTG
 721 CCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGG
 801 AATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGGGACCCCGGCCTCGAGGGTGACCTCC
 881 CTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGAGGACACCTGGCCCAG
 961 CACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGGCTCCT
1041 CTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAG
1121 CAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGA
1201 GCTGACGCCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAA
1281 TCCTCTCAGCCCGCCTTTGCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCC
1361 TGGGGTCGGGGCACCGTGTGGAGTGAGAAAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCT
1441 TCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCCTGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGG
1521 AGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAACTCCCGGGCCTCAGAGTCGGCGCCGGAAACCTA
1601 GGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTTGGATATATTCGGTTAAATAAAAT
1681 CAGCGGTTAGGATTCACAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuACGGGACCGGACAGGGGCGu 5'
            | |:||  |: |||||||| 
Target 5' caTCCTCTTCCTCGTCCCCGCc 3'
 1433 - 1454 160.00 -23.90
2 
miRNA  3' cuaCGGGACCGGA-CAGGGGCgu 5'
             |||||| |:| |||||:|  
Target 5' ccaGCCCTGCCTTGGTCCCTGag 3'
 765 - 787 139.00 -26.60
3 
miRNA  3' cuaCGGGACCGGA-CAGGGGcgu 5'
             |||||| |:| ||||||   
Target 5' ccaGCCCTGCCTTGGTCCCCcaa 3'
 712 - 734 135.00 -27.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
886292 9 ClinVar
257947 19 ClinVar
886291 24 ClinVar
317941 57 ClinVar
886290 89 ClinVar
317940 130 ClinVar
886289 132 ClinVar
884262 135 ClinVar
884261 216 ClinVar
317939 228 ClinVar
317938 241 ClinVar
884260 262 ClinVar
317937 355 ClinVar
884259 359 ClinVar
317936 379 ClinVar
317935 388 ClinVar
317934 396 ClinVar
317933 414 ClinVar
317932 496 ClinVar
888485 510 ClinVar
888484 530 ClinVar
317931 543 ClinVar
317930 592 ClinVar
317929 614 ClinVar
317928 627 ClinVar
887233 632 ClinVar
887232 671 ClinVar
317927 717 ClinVar
317926 735 ClinVar
317925 797 ClinVar
317924 886 ClinVar
317923 887 ClinVar
317922 990 ClinVar
886229 996 ClinVar
886228 1017 ClinVar
886227 1026 ClinVar
886226 1085 ClinVar
317920 1145 ClinVar
317921 1145 ClinVar
317919 1157 ClinVar
317918 1176 ClinVar
885324 1180 ClinVar
317917 1189 ClinVar
885323 1215 ClinVar
317916 1248 ClinVar
885322 1289 ClinVar
317915 1293 ClinVar
317914 1297 ClinVar
888426 1330 ClinVar
317913 1332 ClinVar
888425 1368 ClinVar
317912 1389 ClinVar
317911 1403 ClinVar
317910 1421 ClinVar
317909 1452 ClinVar
317908 1491 ClinVar
317907 1498 ClinVar
887171 1572 ClinVar
887170 1573 ClinVar
317906 1589 ClinVar
887169 1607 ClinVar
887168 1623 ClinVar
317905 1625 ClinVar
317904 1626 ClinVar
317903 1645 ClinVar
886153 1667 ClinVar
317902 1685 ClinVar
COSN28164978 6 COSMIC
COSN30122838 46 COSMIC
COSN31560119 113 COSMIC
COSN24833880 179 COSMIC
COSN20073277 206 COSMIC
COSN30732799 207 COSMIC
COSN31975183 212 COSMIC
COSN24313806 240 COSMIC
COSN26957501 271 COSMIC
COSN23058433 287 COSMIC
COSN32055518 294 COSMIC
COSN32253429 325 COSMIC
COSN8817802 356 COSMIC
COSN27027416 509 COSMIC
COSN20093048 510 COSMIC
COSN6644282 735 COSMIC
COSN8485935 968 COSMIC
COSN17604501 996 COSMIC
COSN6080312 1181 COSMIC
COSN32092220 1400 COSMIC
COSN1183488 1425 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1212234948 2 dbSNP
rs773825294 9 dbSNP
rs1252846135 10 dbSNP
rs746293616 12 dbSNP
rs1312472618 15 dbSNP
rs377124088 16 dbSNP
rs11860968 19 dbSNP
rs1028116858 20 dbSNP
rs1223092969 23 dbSNP
rs1361452118 24 dbSNP
rs771855210 25 dbSNP
rs1448945009 26 dbSNP
rs747601379 30 dbSNP
rs867739286 31 dbSNP
rs778586917 32 dbSNP
rs1408441409 35 dbSNP
rs996591044 36 dbSNP
rs1175587883 38 dbSNP
rs1200967089 40 dbSNP
rs964915035 41 dbSNP
rs754924117 42 dbSNP
rs1407322376 43 dbSNP
rs1389134874 44 dbSNP
rs1162744578 46 dbSNP
rs1300238755 47 dbSNP
rs1019491321 49 dbSNP
rs1454370324 51 dbSNP
rs886051697 57 dbSNP
rs749147014 58 dbSNP
rs368220776 62 dbSNP
rs755846000 63 dbSNP
rs1218314948 68 dbSNP
rs886660784 69 dbSNP
rs1199812568 72 dbSNP
rs1333249516 76 dbSNP
rs1453267071 77 dbSNP
rs563732245 79 dbSNP
rs1208788840 80 dbSNP
rs1350743316 88 dbSNP
rs372232215 89 dbSNP
rs1226225020 97 dbSNP
rs945073586 98 dbSNP
rs1284343639 101 dbSNP
rs1225661775 102 dbSNP
rs1329928230 105 dbSNP
rs1323461403 107 dbSNP
rs757487335 109 dbSNP
rs1387192196 110 dbSNP
rs994819785 113 dbSNP
rs778416836 114 dbSNP
rs1430173820 120 dbSNP
rs1473451608 125 dbSNP
rs1176886885 127 dbSNP
rs561217125 130 dbSNP
rs764192196 132 dbSNP
rs768968043 133 dbSNP
rs1447475331 134 dbSNP
rs1249374686 135 dbSNP
rs1206219470 137 dbSNP
rs1435056780 139 dbSNP
rs547400996 140 dbSNP
rs527452340 141 dbSNP
rs565091497 142 dbSNP
rs1343284357 147 dbSNP
rs934499974 148 dbSNP
rs545083540 149 dbSNP
rs978673361 150 dbSNP
rs1350371020 152 dbSNP
rs947072104 155 dbSNP
rs1203928107 159 dbSNP
rs1328657094 160 dbSNP
rs776669247 161 dbSNP
rs1292582374 162 dbSNP
rs920897845 164 dbSNP
rs777148736 165 dbSNP
rs771800053 166 dbSNP
rs576207292 167 dbSNP
rs965476929 171 dbSNP
rs1353791511 173 dbSNP
rs1411000255 179 dbSNP
rs1468364828 179 dbSNP
rs562621944 183 dbSNP
rs1016290282 185 dbSNP
rs1475709217 186 dbSNP
rs1391869133 187 dbSNP
rs1186198152 190 dbSNP
rs1448335800 192 dbSNP
rs551689683 193 dbSNP
rs542599023 194 dbSNP
rs1394232208 196 dbSNP
rs1243426524 197 dbSNP
rs1211759786 199 dbSNP
rs774184483 200 dbSNP
rs1278385914 201 dbSNP
rs1237263182 202 dbSNP
rs1196685822 203 dbSNP
rs1344938228 206 dbSNP
rs768254023 207 dbSNP
rs1227835024 209 dbSNP
rs1383579465 212 dbSNP
rs1317204515 215 dbSNP
rs528735755 216 dbSNP
rs748883273 217 dbSNP
rs1289736139 219 dbSNP
rs779854652 220 dbSNP
rs756086004 222 dbSNP
rs1026562223 223 dbSNP
rs1250017620 224 dbSNP
rs143364973 228 dbSNP
rs899177207 230 dbSNP
rs1428587158 231 dbSNP
rs1385346554 232 dbSNP
rs998450555 235 dbSNP
rs1443985715 236 dbSNP
rs1022879667 237 dbSNP
rs1471612153 238 dbSNP
rs900908722 240 dbSNP
rs559965660 241 dbSNP
rs1183066370 243 dbSNP
rs1167588422 245 dbSNP
rs1484231893 247 dbSNP
rs535031741 250 dbSNP
rs1336620699 251 dbSNP
rs751751949 254 dbSNP
rs1360737756 256 dbSNP
rs572569244 262 dbSNP
rs893435889 264 dbSNP
rs558738228 267 dbSNP
rs368348780 268 dbSNP
rs1355998152 271 dbSNP
rs1280345881 272 dbSNP
rs1410260597 273 dbSNP
rs1337764817 274 dbSNP
rs1352063178 276 dbSNP
rs779726311 278 dbSNP
rs367705655 283 dbSNP
rs768940839 283 dbSNP
rs938270696 283 dbSNP
rs1249744563 284 dbSNP
rs752825359 290 dbSNP
rs1366052343 291 dbSNP
rs765603311 293 dbSNP
rs760110558 294 dbSNP
rs949610414 297 dbSNP
rs538889913 299 dbSNP
rs1158761509 301 dbSNP
rs1043002900 302 dbSNP
rs374403360 311 dbSNP
rs920948402 317 dbSNP
rs1269621657 318 dbSNP
rs975454994 319 dbSNP
rs1490658524 320 dbSNP
rs972117859 321 dbSNP
rs766816261 323 dbSNP
rs1451086627 325 dbSNP
rs943703388 328 dbSNP
rs755587221 331 dbSNP
rs982547799 337 dbSNP
rs950918330 338 dbSNP
rs1229857717 342 dbSNP
rs761166293 346 dbSNP
rs1026405044 349 dbSNP
rs768419661 350 dbSNP
rs1433733497 353 dbSNP
rs886051696 355 dbSNP
rs953985444 356 dbSNP
rs1465334179 357 dbSNP
rs762306226 359 dbSNP
rs1204457063 362 dbSNP
rs1023162670 363 dbSNP
rs1013357824 366 dbSNP
rs1434349747 368 dbSNP
rs1480961649 374 dbSNP
rs1427926218 375 dbSNP
rs775637701 377 dbSNP
rs753373584 379 dbSNP
rs775081376 381 dbSNP
rs769573664 385 dbSNP
rs1210604358 386 dbSNP
rs965161191 387 dbSNP
rs745852264 388 dbSNP
rs193128748 389 dbSNP
rs556271192 392 dbSNP
rs1388529775 394 dbSNP
rs149057560 396 dbSNP
rs1217431714 401 dbSNP
rs903021510 402 dbSNP
rs1002299038 403 dbSNP
rs886051695 414 dbSNP
rs1258833430 416 dbSNP
rs1360558789 421 dbSNP
rs1489178181 421 dbSNP
rs905428385 422 dbSNP
rs1011512218 427 dbSNP
rs1315479151 428 dbSNP
rs1183860285 438 dbSNP
rs899778304 439 dbSNP
rs1039604983 442 dbSNP
rs1222606525 443 dbSNP
rs1373224822 448 dbSNP
rs567572398 450 dbSNP
rs1411123099 455 dbSNP
rs1362494809 457 dbSNP
rs1459893600 459 dbSNP
rs1363337053 461 dbSNP
rs1047055924 463 dbSNP
rs1302076579 464 dbSNP
rs1403379788 471 dbSNP
rs949678454 472 dbSNP
rs1373804279 474 dbSNP
rs943741265 478 dbSNP
rs897955164 486 dbSNP
rs1036539158 487 dbSNP
rs942084304 495 dbSNP
rs60516531 496 dbSNP
rs1047257623 503 dbSNP
rs1356596303 505 dbSNP
rs1232429826 509 dbSNP
rs527600278 510 dbSNP
rs571420082 513 dbSNP
rs1481164618 514 dbSNP
rs1177054417 517 dbSNP
rs973572267 519 dbSNP
rs542865583 520 dbSNP
rs188481235 530 dbSNP
rs562556695 542 dbSNP
rs542386664 543 dbSNP
rs765947375 544 dbSNP
rs1035657965 547 dbSNP
rs999364830 548 dbSNP
rs967426450 549 dbSNP
rs1021704384 552 dbSNP
rs1011438412 553 dbSNP
rs1389229029 562 dbSNP
rs1379956523 569 dbSNP
rs1229878121 573 dbSNP
rs899665281 574 dbSNP
rs1040058145 575 dbSNP
rs1343037314 583 dbSNP
rs987976974 591 dbSNP
rs184831951 592 dbSNP
rs1184767659 596 dbSNP
rs1243003510 601 dbSNP
rs1443322549 602 dbSNP
rs559911117 603 dbSNP
rs1001971204 613 dbSNP
rs886051694 614 dbSNP
rs1470069825 615 dbSNP
rs1336003243 616 dbSNP
rs780705841 626 dbSNP
rs10903009 627 dbSNP
rs572410653 631 dbSNP
rs751460368 632 dbSNP
rs898113589 633 dbSNP
rs1212473317 636 dbSNP
rs1036529334 639 dbSNP
rs1326110345 640 dbSNP
rs1204784164 641 dbSNP
rs1262895517 642 dbSNP
rs1345717866 644 dbSNP
rs1211096469 648 dbSNP
rs1161208738 651 dbSNP
rs929633612 652 dbSNP
rs919702044 665 dbSNP
rs1427338677 667 dbSNP
rs866824383 669 dbSNP
rs1038084372 670 dbSNP
rs1427445361 671 dbSNP
rs1480881492 676 dbSNP
rs368105820 682 dbSNP
rs887958413 683 dbSNP
rs1458791680 701 dbSNP
rs1344112791 703 dbSNP
rs1434042848 704 dbSNP
rs916047304 708 dbSNP
rs1269736033 709 dbSNP
rs1294772737 710 dbSNP
rs992153993 711 dbSNP
rs1345816690 713 dbSNP
rs886051693 717 dbSNP
rs1321812234 727 dbSNP
rs1050917424 728 dbSNP
rs1185150591 732 dbSNP
rs1485714853 734 dbSNP
rs2294542 735 dbSNP
rs928640715 742 dbSNP
rs545179030 752 dbSNP
rs1271120295 759 dbSNP
rs1321991139 760 dbSNP
rs1198930226 762 dbSNP
rs576256047 767 dbSNP
rs1426980328 777 dbSNP
rs1040411774 783 dbSNP
rs1021757038 789 dbSNP
rs943957066 792 dbSNP
rs1332528534 796 dbSNP
rs1407255432 796 dbSNP
rs886051692 797 dbSNP
rs913847434 803 dbSNP
rs1403989876 809 dbSNP
rs987918347 812 dbSNP
rs760078737 819 dbSNP
rs964226553 820 dbSNP
rs556590821 822 dbSNP
rs1280497507 835 dbSNP
rs1008578275 836 dbSNP
rs891014072 841 dbSNP
rs1294092463 844 dbSNP
rs543930400 853 dbSNP
rs969174957 857 dbSNP
rs1266968795 858 dbSNP
rs1322264821 861 dbSNP
rs993835209 862 dbSNP
rs1232070721 867 dbSNP
rs1468213184 868 dbSNP
rs1405247579 879 dbSNP
rs1013297941 883 dbSNP
rs1385340757 884 dbSNP
rs1050834 886 dbSNP
rs6600146 887 dbSNP
rs370691055 888 dbSNP
rs879705233 888 dbSNP
rs1372090213 891 dbSNP
rs1410166717 899 dbSNP
rs1006496243 902 dbSNP
rs1168544078 906 dbSNP
rs1440688685 907 dbSNP
rs1050622258 908 dbSNP
rs1249074483 912 dbSNP
rs1245252993 914 dbSNP
rs996655674 915 dbSNP
rs901963716 918 dbSNP
rs1243067690 919 dbSNP
rs947768077 921 dbSNP
rs1272067399 923 dbSNP
rs1040757316 925 dbSNP
rs1346432166 929 dbSNP
rs894653387 930 dbSNP
rs1249282058 931 dbSNP
rs1243612415 934 dbSNP
rs1055939882 936 dbSNP
rs192589258 937 dbSNP
rs1299624093 938 dbSNP
rs928925376 940 dbSNP
rs1374268850 949 dbSNP
rs1475558764 950 dbSNP
rs1052283290 955 dbSNP
rs1396253247 957 dbSNP
rs534244443 958 dbSNP
rs1408515934 964 dbSNP
rs1339273963 975 dbSNP
rs866505130 978 dbSNP
rs946064090 980 dbSNP
rs571557062 981 dbSNP
rs1228461970 982 dbSNP
rs761010841 986 dbSNP
rs114884549 990 dbSNP
rs964135524 994 dbSNP
rs1018535341 996 dbSNP
rs1263510385 997 dbSNP
rs1460849866 1002 dbSNP
rs1201652545 1003 dbSNP
rs986677190 1004 dbSNP
rs1428540135 1005 dbSNP
rs1461713190 1011 dbSNP
rs1370917309 1014 dbSNP
rs955383044 1016 dbSNP
rs1430382276 1017 dbSNP
rs1469769771 1019 dbSNP
rs1025552868 1024 dbSNP
rs761591980 1026 dbSNP
rs1382788197 1036 dbSNP
rs898169147 1046 dbSNP
rs1317724810 1048 dbSNP
rs1385173010 1049 dbSNP
rs531513124 1052 dbSNP
rs1011966090 1053 dbSNP
rs1444606650 1054 dbSNP
rs894924462 1059 dbSNP
rs569096645 1064 dbSNP
rs1204107551 1067 dbSNP
rs938901889 1068 dbSNP
rs907357028 1069 dbSNP
rs1270081042 1077 dbSNP
rs774171914 1084 dbSNP
rs1174585279 1085 dbSNP
rs1029571902 1087 dbSNP
rs946239214 1089 dbSNP
rs914592068 1090 dbSNP
rs1358664567 1096 dbSNP
rs990119593 1097 dbSNP
rs901908562 1101 dbSNP
rs1344650210 1102 dbSNP
rs376255129 1106 dbSNP
rs1308873897 1107 dbSNP
rs911351114 1110 dbSNP
rs987283828 1113 dbSNP
rs1238204381 1114 dbSNP
rs376254217 1118 dbSNP
rs1360917893 1119 dbSNP
rs1222788570 1122 dbSNP
rs918382870 1123 dbSNP
rs891761041 1126 dbSNP
rs1054394758 1127 dbSNP
rs936579220 1133 dbSNP
rs972644014 1136 dbSNP
rs962573919 1137 dbSNP
rs1365258145 1139 dbSNP
rs1456571045 1139 dbSNP
rs1299708429 1140 dbSNP
rs146690487 1145 dbSNP
rs1306919340 1146 dbSNP
rs1409277940 1149 dbSNP
rs1016794968 1152 dbSNP
rs1011937287 1153 dbSNP
rs1341196675 1154 dbSNP
rs9921 1157 dbSNP
rs940428925 1158 dbSNP
rs907529654 1160 dbSNP
rs984493643 1163 dbSNP
rs1310024863 1164 dbSNP
rs952375139 1169 dbSNP
rs150325021 1176 dbSNP
rs1365296906 1177 dbSNP
rs370167870 1180 dbSNP
rs1384662984 1181 dbSNP
rs188360039 1182 dbSNP
rs886051691 1189 dbSNP
rs1354910513 1190 dbSNP
rs1461239283 1196 dbSNP
rs565215279 1197 dbSNP
rs1010503801 1206 dbSNP
rs1010245441 1207 dbSNP
rs1313785001 1212 dbSNP
rs893418963 1215 dbSNP
rs1215982007 1216 dbSNP
rs1295770734 1234 dbSNP
rs1054712023 1241 dbSNP
rs373977873 1247 dbSNP
rs371394735 1248 dbSNP
rs1290387815 1254 dbSNP
rs1242635691 1261 dbSNP
rs1482285642 1264 dbSNP
rs1211396609 1266 dbSNP
rs1032972976 1267 dbSNP
rs1168339879 1269 dbSNP
rs550477279 1277 dbSNP
rs747728516 1281 dbSNP
rs1044960912 1282 dbSNP
rs879374511 1283 dbSNP
rs545314491 1285 dbSNP
rs1432203259 1287 dbSNP
rs947968376 1291 dbSNP
rs896286031 1292 dbSNP
rs529027139 1293 dbSNP
rs934046030 1295 dbSNP
rs556488187 1297 dbSNP
rs907647514 1299 dbSNP
rs1278457415 1301 dbSNP
rs1324699801 1304 dbSNP
rs1218112802 1307 dbSNP
rs1462872744 1310 dbSNP
rs1407368193 1317 dbSNP
rs1383459298 1318 dbSNP
rs1485690116 1319 dbSNP
rs1159018353 1325 dbSNP
rs941439 1332 dbSNP
rs930295387 1338 dbSNP
rs1413587672 1352 dbSNP
rs574047404 1353 dbSNP
rs962501039 1354 dbSNP
rs1479938303 1361 dbSNP
rs909841674 1363 dbSNP
rs140066822 1367 dbSNP
rs376131222 1368 dbSNP
rs1200733943 1373 dbSNP
rs1304520483 1374 dbSNP
rs988978882 1375 dbSNP
rs1351285114 1376 dbSNP
rs710900 1389 dbSNP
rs1366179046 1390 dbSNP
rs1003310547 1391 dbSNP
rs1033086552 1393 dbSNP
rs970043936 1394 dbSNP
rs1490573064 1400 dbSNP
rs1197973719 1401 dbSNP
rs886051690 1403 dbSNP
rs1471141796 1405 dbSNP
rs1012156603 1406 dbSNP
rs1406626681 1407 dbSNP
rs1417247579 1410 dbSNP
rs896442497 1411 dbSNP
rs1331093734 1412 dbSNP
rs1020701011 1419 dbSNP
rs886051689 1421 dbSNP
rs1329667815 1424 dbSNP
rs1184860786 1425 dbSNP
rs138851469 1428 dbSNP
rs746018594 1435 dbSNP
rs1048777268 1439 dbSNP
rs1054724158 1446 dbSNP
rs28429525 1448 dbSNP
rs930394724 1449 dbSNP
rs1439083431 1451 dbSNP
rs578092313 1452 dbSNP
rs889814660 1453 dbSNP
rs1039146225 1454 dbSNP
rs1205139828 1460 dbSNP
rs1237563095 1461 dbSNP
rs1051506693 1462 dbSNP
rs933980895 1463 dbSNP
rs918695557 1468 dbSNP
rs1437732153 1477 dbSNP
rs182110116 1479 dbSNP
rs1385276060 1485 dbSNP
rs941230995 1486 dbSNP
rs886051688 1491 dbSNP
rs909684761 1492 dbSNP
rs1411941854 1495 dbSNP
rs1391449537 1497 dbSNP
rs373942084 1498 dbSNP
rs1445188552 1499 dbSNP
rs1338829369 1508 dbSNP
rs990755038 1509 dbSNP
rs538156151 1510 dbSNP
rs1282575913 1511 dbSNP
rs1341729838 1517 dbSNP
rs937899366 1522 dbSNP
rs926142809 1523 dbSNP
rs978834741 1524 dbSNP
rs569034711 1526 dbSNP
rs1022962606 1528 dbSNP
rs1243238549 1528 dbSNP
rs982212047 1528 dbSNP
rs966347506 1529 dbSNP
rs1020751702 1531 dbSNP
rs989197296 1533 dbSNP
rs776898053 1534 dbSNP
rs1241345429 1535 dbSNP
rs1464549570 1536 dbSNP
rs960598455 1542 dbSNP
rs1466253555 1544 dbSNP
rs957530520 1545 dbSNP
rs1034904693 1549 dbSNP
rs1201869091 1552 dbSNP
rs1328471412 1552 dbSNP
rs548912339 1554 dbSNP
rs1004819320 1555 dbSNP
rs780423947 1556 dbSNP
rs1049378395 1557 dbSNP
rs994590555 1558 dbSNP
rs1033574484 1566 dbSNP
rs771120676 1568 dbSNP
rs1221197610 1571 dbSNP
rs539134149 1572 dbSNP
rs778327342 1573 dbSNP
rs890063151 1573 dbSNP
rs566427443 1574 dbSNP
rs1297398057 1575 dbSNP
rs1263196203 1576 dbSNP
rs1447263686 1577 dbSNP
rs944405679 1579 dbSNP
rs1262950891 1582 dbSNP
rs1477013207 1585 dbSNP
rs1179026343 1586 dbSNP
rs546700450 1588 dbSNP
rs532736933 1589 dbSNP
rs563752591 1590 dbSNP
rs189885447 1591 dbSNP
rs998181055 1592 dbSNP
rs531884652 1596 dbSNP
rs187858513 1598 dbSNP
rs386787706 1599 dbSNP
rs926134521 1602 dbSNP
rs941409246 1607 dbSNP
rs948813626 1608 dbSNP
rs570138089 1616 dbSNP
rs1055335679 1617 dbSNP
rs916008227 1619 dbSNP
rs1451036503 1623 dbSNP
rs143409179 1625 dbSNP
rs8767 1626 dbSNP
rs386787705 1627 dbSNP
rs1215462103 1629 dbSNP
rs927892002 1639 dbSNP
rs74002247 1645 dbSNP
rs945033457 1649 dbSNP
rs560362445 1651 dbSNP
rs983335193 1659 dbSNP
rs1238175519 1661 dbSNP
rs780617974 1667 dbSNP
rs989249612 1668 dbSNP
rs957748690 1675 dbSNP
rs1420308731 1679 dbSNP
rs1158122812 1683 dbSNP
rs540753146 1684 dbSNP
rs376387077 1685 dbSNP
rs954235570 1691 dbSNP
rs1017744237 1697 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuacgggaccGGA-CAGGGGCGu 5'
                    ||| |||||||| 
Target 5' ---------uCCUCGUCCCCGCc 3'
 		1 - 14
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_001114331 | 3UTR | CUCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001287 | 3UTR | UCCUCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001114331 | 3UTR | CUCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001114331 | 3UTR | UCCUCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001114331 | 3UTR | UCCUCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001114331 | 3UTR | UCUUCCUCGUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000448525.1 | 3UTR | UCCUCGUCCCCGCCCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
54 hsa-miR-4749-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT062471 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT216687 F2R coagulation factor II thrombin receptor 2 2
MIRT452932 DISC1 disrupted in schizophrenia 1 2 2
MIRT457070 TOR4A torsin family 4 member A 2 2
MIRT464196 VGLL4 vestigial like family member 4 2 4
MIRT464974 TULP1 tubby like protein 1 2 6
MIRT471714 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473152 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT476086 GRB2 growth factor receptor bound protein 2 2 2
MIRT477697 EFHD2 EF-hand domain family member D2 2 2
MIRT480159 CALR calreticulin 2 2
MIRT483732 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484553 BARHL1 BarH like homeobox 1 2 6
MIRT485994 YIPF2 Yip1 domain family member 2 2 2
MIRT486530 CLCN7 chloride voltage-gated channel 7 2 2
MIRT487220 HIC1 HIC ZBTB transcriptional repressor 1 2 2
MIRT487799 GPR20 G protein-coupled receptor 20 2 4
MIRT487879 CASZ1 castor zinc finger 1 2 4
MIRT489682 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489735 GNAI2 G protein subunit alpha i2 2 4
MIRT489754 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT489841 HCFC1 host cell factor C1 2 2
MIRT490386 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490584 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490722 SLC9A3 solute carrier family 9 member A3 2 2
MIRT490741 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491705 PDZD4 PDZ domain containing 4 2 2
MIRT491743 SEMA3F semaphorin 3F 2 2
MIRT492740 PER1 period circadian clock 1 2 10
MIRT493162 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493414 KDM6B lysine demethylase 6B 2 2
MIRT493716 H2AFX H2A histone family member X 2 2
MIRT494628 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494709 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495753 PDE4C phosphodiesterase 4C 2 4
MIRT499605 ANKRD45 ankyrin repeat domain 45 2 2
MIRT501164 SLC10A7 solute carrier family 10 member 7 2 6
MIRT502116 KMT2D lysine methyltransferase 2D 2 2
MIRT502657 CTC1 CST telomere replication complex component 1 2 12
MIRT516766 FAM212B family with sequence similarity 212 member B 2 4
MIRT531190 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531975 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT569101 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569315 CC2D1B coiled-coil and C2 domain containing 1B 2 2
MIRT569535 CTTN cortactin 2 2
MIRT569851 RGS5 regulator of G protein signaling 5 2 2
MIRT570594 NFIX nuclear factor I X 2 2
MIRT608759 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT616276 HOXD11 homeobox D11 2 2
MIRT639725 RAB17 RAB17, member RAS oncogene family 2 2
MIRT661072 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT703496 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT712894 TGFA transforming growth factor alpha 2 2
MIRT721299 C3orf36 chromosome 3 open reading frame 36 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4749-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4749-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4749-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4749-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4749-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4749-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4749-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4749-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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