miRTarBase - #MIRT486550


—
pre-miRNA Information
pre-miRNA hsa-mir-4690   
Genomic Coordinates chr11: 65636310 - 65636369
Description Homo sapiens miR-4690 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4690-5p
Sequence 1| GAGCAGGCGAGGCUGGGCUGAA |22
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM5426974 4 COSMIC
COSM7294383 4 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs762767645 3 dbSNP
rs1158020577 4 dbSNP
rs1031810148 7 dbSNP
rs763979181 8 dbSNP
rs751083148 11 dbSNP
rs1338601494 12 dbSNP
rs1403894228 14 dbSNP
rs541332946 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DCTN4   
Synonyms DYN4, P62
Description dynactin subunit 4
Transcript NM_001135643   
Other Transcripts NM_001135644 , NM_016221   
Expression
Putative miRNA Targets on DCTN4
3'UTR of DCTN4
(miRNA target sites are highlighted)		 
>DCTN4|NM_001135643|3'UTR
   1 AAGGTTCCACTGGAGGGCAGATCCCAAAGGACAGTATCACCGTAAACCTGCGTTAAAATGTGGAAGCTGCTGCTTCATTA
  81 GGCCTTGTTTATAACGATGTACCCATGCACTACGGAATTCTATTGCTAAGAAAGTGGGAGCATAGGCAAGGCATTGGGAA
 161 CACAGGGTAGCTGCTGTTGCTCTTGCTCTCACCCCTGTTGACACCAGTAAGTCTGTGTCTCCCTCACTGAACCCTGCACG
 241 TTGAGTAACAGCAGCATAATTCCATCCTAGGAAAGGGGATGGGTGTTCCTTGGAATGGCATTGTATTTACCACCTGAGAA
 321 ACTCTGTACTGTCTCTTGATCTGATCTCACTAAGGATCACAATGTCACAGATGAAACTTAAATGATAACCCAAAGGTAGA
 401 CCTGCTGTTAATGATCCAGCATTGGTCACAATGTACCAACTGCTTTCTGCATTCCGTTAAATATCATCTAACAGTCTAAA
 481 ACATATCCCTTCATTGCCATAATGGCTGCCATTTTGCCATAGATTTCCATATAACTGAAAAACTGAATTGTCACTTTATC
 561 TTTAGTATCATGATGATTGGAAAAACCTGTGAAGTTGTTAAGGCACTCTCATTTGCCCTCTTTTTCTAAGTGAATACAGG
 641 ACACGTATTAGTTGTTCTTAATTTTTTTCCCAGTAAAATATGGATCTTTTAAGAAGAATTTGAGAAGCAAACAATTACAT
 721 GTCATGTCAAGGGGGTAGCAGATTCCATTCGTTTTCAATATTGCCACAATACCCAGGGATTAATGCTGCCACAGGGGGGC
 801 AATCTTTATTTGTCTTACTTCCTACCCCTTCCCTGTTCTGCCTCTTTAACTCAGTTAAGTTGTTCTGTTTGGGACCTGGA
 881 AAAGAACCCAAAGAAAACCTGAGTGGACAGGTTCATTTCTGGAATGCAGAAAACATTTTAAAGGCTAGATTTTTAGAATA
 961 TTCTCAACTAGCATTCTTTCCATTGATTTGAAGGGGAAATTAACTATTATAATCTCTTGAATCCAAAACTGGATATTAAG
1041 AACTTTCCCCCTTACTAAGTTTAAGACTTTTGTCATGTGGTGAGTCAAATAAGACCATTTTGATTGTAAACCATAAAATA
1121 GTTCAGCAAGTAGCCCACAGTTCTGGCCTAACAGCAGACTTGCTGTTTTCACTTGGTATCCTGGAGTTGGGTTGCTAACC
1201 TTAATTTCTATGATGTTTTCTAAAATGAAACTTGATAAAGTAGACCACCAGCTGCACCGTGTTTTCTGTAAAAGTATTGT
1281 TAGTAAGTGGCCAAGAGACTTGAGGAAAATACAGATTTTTTGTTTACCTTGGTCTTGTTTTAAGTCTTAAAAAATTAAAG
1361 ATAACATTATAATGTAGAATACAGATGGGACATAGTCCTTGTAAGCTTCCCTTGAAAATGTTTTAAATATTTAGGAAGCT
1441 TTTAAAAGACACTAAATTGTACTCTAAAAGACACTAAATTGTACTAATTGTACAAAGGTCAAGCCAATTTTATGAAACAG
1521 TCCTACAGAGTAATATATGTGATGCAGTGTAAGAAGGAAAATACTCATCTCTAACATTATGGTAATAACATTTAGCCTCT
1601 TAGGAGTTGGAGCAGGGGGATGGGTAATTACAGATTTGCAGACTATAGAAAGAGTTTCATTTTTTTGTGACCCCACAGAG
1681 TCTCAAATTTTTATTTCACTACCTGCTAGAGCCTACTGTGAAATCACTGCTCCATATTTGCCAGTGGAGGAAATGGGCAT
1761 AGAGTAGAGAATAGCTTCATATGTTTACACGTTTGCATAGACTACACACATGTCATGCGTTTATGGCAGGTAGCTGGTAT
1841 TTATTCCCCAAAGTAATAATGTTGAAGTATGGGTCTCATCATTCCCATACACAGAAACACAAAACACTTTGATCATAAAC
1921 TTTTTTCTTCAGAAGCCAAACTAACTTGCAGAATAATAGAGCCACTGGTTTAATGTTTCCTCAAGATAGGTTTTAGTGTA
2001 AGCTAGTATTCTGTGTGTTCGTAGAAATGATTCAATACCTGCAGCTGGTGAATTAGGAATTGTATTTGTTGCCTTTTTTA
2081 TATTAGATGAGGTGCAAAAATTTTAATGCTAGTCAGTATGCACCACCACAGGAAAGTTAGATCCCATTAGCACTTGAAAC
2161 TACAGCTTTGGAAACTTAGGCTAAGTTAATTTGGATTTGTTACTTGATTCACCTACTGACCTTTTCTTTTGTTTGAAGTG
2241 CTTATCAGCATAATGAGCTAAGTGTCATGCATATTTGTGAAGAAACACCCTTTTTGGTCCCTTTTGGGACAGAGAGGTAC
2321 TCCTTGATCTTTATGAATGACAGGTTACTGTTTTGCCTTATTGCTTAACTTAATGTAGTGAAATAAAGCAGACAAAGCTT
2401 GAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aagucgggucggagcGGACGAg 5'
                         |||||| 
Target 5' taacccaaaggtagaCCTGCTg 3'
 386 - 407 120.00 -13.20
2 
miRNA  3' aagucgggucggagcGGACGAg 5'
                         |||||| 
Target 5' atttttatttcactaCCTGCTa 3'
 1687 - 1708 120.00 -11.20
3 
miRNA  3' aagucGGGU-CGGAGCGGACGAg 5'
               ||:|  |||: ||||:| 
Target 5' tacttCCTACCCCTTCCCTGTTc 3'
 816 - 838 113.00 -18.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30458654 3 COSMIC
COSN30182656 16 COSMIC
COSN31492461 48 COSMIC
COSN30510320 59 COSMIC
COSN31554160 113 COSMIC
COSN30140747 138 COSMIC
COSN30177055 190 COSMIC
COSN31600229 213 COSMIC
COSN7880416 294 COSMIC
COSN14699465 418 COSMIC
COSN9411498 474 COSMIC
COSN20091285 1143 COSMIC
COSN25308198 1421 COSMIC
COSN21969411 1713 COSMIC
COSN20560631 2084 COSMIC
COSN24103855 2142 COSMIC
COSN32190740 2235 COSMIC
COSN17684183 2703 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1473403492 10 dbSNP
rs1245447027 13 dbSNP
rs755217094 14 dbSNP
rs747380320 15 dbSNP
rs780505866 16 dbSNP
rs758993228 22 dbSNP
rs374616347 25 dbSNP
rs765807312 30 dbSNP
rs1218073799 32 dbSNP
rs1364912280 33 dbSNP
rs201920711 37 dbSNP
rs781053588 40 dbSNP
rs760310764 41 dbSNP
rs199962532 42 dbSNP
rs1455168305 47 dbSNP
rs767251447 48 dbSNP
rs377589711 51 dbSNP
rs1056604314 52 dbSNP
rs1179081251 62 dbSNP
rs1404354986 73 dbSNP
rs1469018054 77 dbSNP
rs888760441 91 dbSNP
rs536764862 95 dbSNP
rs1459085595 96 dbSNP
rs1379986983 98 dbSNP
rs1294797907 100 dbSNP
rs756969916 103 dbSNP
rs1346124880 105 dbSNP
rs1386715953 112 dbSNP
rs1225266991 113 dbSNP
rs1048975367 114 dbSNP
rs904885562 119 dbSNP
rs1232814366 120 dbSNP
rs769297008 122 dbSNP
rs1044678602 130 dbSNP
rs1486905171 140 dbSNP
rs186059638 142 dbSNP
rs948976589 143 dbSNP
rs1262529489 145 dbSNP
rs1490674808 146 dbSNP
rs914823207 148 dbSNP
rs1054663661 158 dbSNP
rs1461971851 166 dbSNP
rs1427651303 167 dbSNP
rs140284460 179 dbSNP
rs763458041 181 dbSNP
rs1185391768 187 dbSNP
rs1451145689 188 dbSNP
rs539274899 194 dbSNP
rs758374820 195 dbSNP
rs924745643 197 dbSNP
rs987310193 206 dbSNP
rs955457620 207 dbSNP
rs1262247781 214 dbSNP
rs1190256076 218 dbSNP
rs1406713058 221 dbSNP
rs371714786 227 dbSNP
rs569762046 227 dbSNP
rs567475023 235 dbSNP
rs921272231 238 dbSNP
rs1391713268 239 dbSNP
rs938022047 240 dbSNP
rs1318998856 250 dbSNP
rs752532504 257 dbSNP
rs563445066 271 dbSNP
rs1016852766 282 dbSNP
rs1243306909 283 dbSNP
rs1340397898 285 dbSNP
rs1488371217 291 dbSNP
rs765185988 301 dbSNP
rs1004077537 312 dbSNP
rs988292356 315 dbSNP
rs951270252 318 dbSNP
rs1034835124 322 dbSNP
rs966217035 326 dbSNP
rs3733924 331 dbSNP
rs1161622904 333 dbSNP
rs1349280009 352 dbSNP
rs1299739746 362 dbSNP
rs953166246 362 dbSNP
rs10044819 363 dbSNP
rs3733925 367 dbSNP
rs1010520503 371 dbSNP
rs1383661001 383 dbSNP
rs1289653121 385 dbSNP
rs548732343 386 dbSNP
rs1321684398 391 dbSNP
rs1036176541 399 dbSNP
rs1253463808 401 dbSNP
rs1479824625 411 dbSNP
rs1177660064 412 dbSNP
rs1393018603 421 dbSNP
rs117243230 423 dbSNP
rs895620764 424 dbSNP
rs1056959334 425 dbSNP
rs938068849 428 dbSNP
rs567237519 431 dbSNP
rs1352545990 435 dbSNP
rs934907661 437 dbSNP
rs1373516455 438 dbSNP
rs548730060 439 dbSNP
rs924788664 445 dbSNP
rs1330958782 451 dbSNP
rs1051236986 455 dbSNP
rs934064636 456 dbSNP
rs551157996 460 dbSNP
rs1282565249 461 dbSNP
rs1378455237 464 dbSNP
rs3839276 466 dbSNP
rs1298321291 467 dbSNP
rs1193927160 473 dbSNP
rs1452946582 475 dbSNP
rs914178298 476 dbSNP
rs532965166 480 dbSNP
rs975442987 482 dbSNP
rs1236396488 502 dbSNP
rs1475416622 519 dbSNP
rs1188236107 529 dbSNP
rs1356281707 531 dbSNP
rs1417240048 531 dbSNP
rs1176939209 535 dbSNP
rs77257224 543 dbSNP
rs912025845 544 dbSNP
rs775707342 545 dbSNP
rs74600056 547 dbSNP
rs1437537543 555 dbSNP
rs953148022 560 dbSNP
rs1027305574 565 dbSNP
rs1321684511 565 dbSNP
rs768579924 566 dbSNP
rs74635039 569 dbSNP
rs1035268652 570 dbSNP
rs961665152 573 dbSNP
rs1309718847 578 dbSNP
rs1326023265 578 dbSNP
rs1277424015 580 dbSNP
rs1003376173 587 dbSNP
rs1217372440 597 dbSNP
rs562633614 600 dbSNP
rs561312717 604 dbSNP
rs1174029024 610 dbSNP
rs1200042337 615 dbSNP
rs1431166302 620 dbSNP
rs1478841061 622 dbSNP
rs181022362 628 dbSNP
rs1862183 634 dbSNP
rs1197555751 637 dbSNP
rs1002732602 641 dbSNP
rs905262834 644 dbSNP
rs1010554608 645 dbSNP
rs1347813779 660 dbSNP
rs913873142 669 dbSNP
rs946713728 669 dbSNP
rs1207984335 670 dbSNP
rs1225107188 680 dbSNP
rs76430591 685 dbSNP
rs1030639421 689 dbSNP
rs1352252630 710 dbSNP
rs867157344 713 dbSNP
rs543483437 714 dbSNP
rs999522175 725 dbSNP
rs1270898578 728 dbSNP
rs1220119137 730 dbSNP
rs903394569 732 dbSNP
rs1051739088 735 dbSNP
rs1347403828 740 dbSNP
rs200828868 745 dbSNP
rs1273256250 750 dbSNP
rs115870230 751 dbSNP
rs899946493 756 dbSNP
rs1419125948 758 dbSNP
rs1164791512 761 dbSNP
rs986304386 766 dbSNP
rs746305373 769 dbSNP
rs941401457 781 dbSNP
rs1336710218 786 dbSNP
rs368208066 794 dbSNP
rs1375550384 795 dbSNP
rs961695978 795 dbSNP
rs1354249426 799 dbSNP
rs1209156542 800 dbSNP
rs1439275266 801 dbSNP
rs578128958 802 dbSNP
rs1236529126 804 dbSNP
rs982765003 810 dbSNP
rs929923713 816 dbSNP
rs144096507 822 dbSNP
rs1313279870 824 dbSNP
rs1472128340 825 dbSNP
rs1163124998 827 dbSNP
rs188371064 831 dbSNP
rs34871102 834 dbSNP
rs567901438 834 dbSNP
rs1043545 848 dbSNP
rs1329699681 848 dbSNP
rs1205789643 849 dbSNP
rs185513405 860 dbSNP
rs1171589350 861 dbSNP
rs1470297686 862 dbSNP
rs1243986438 869 dbSNP
rs372609318 876 dbSNP
rs1341233711 879 dbSNP
rs569365710 880 dbSNP
rs957779184 882 dbSNP
rs150882676 884 dbSNP
rs999196762 897 dbSNP
rs1251638766 901 dbSNP
rs1022397429 905 dbSNP
rs1440704339 908 dbSNP
rs532702860 909 dbSNP
rs1010958521 910 dbSNP
rs1476657254 915 dbSNP
rs1169071754 924 dbSNP
rs28622467 945 dbSNP
rs547302439 948 dbSNP
rs1444439502 949 dbSNP
rs1470012185 957 dbSNP
rs1276918208 977 dbSNP
rs1200133082 983 dbSNP
rs1338223976 994 dbSNP
rs1399477002 996 dbSNP
rs374040482 997 dbSNP
rs529171322 1006 dbSNP
rs998378017 1008 dbSNP
rs747417721 1009 dbSNP
rs1328166173 1010 dbSNP
rs1216714667 1017 dbSNP
rs181422973 1032 dbSNP
rs543037543 1040 dbSNP
rs1270159739 1047 dbSNP
rs1257932060 1051 dbSNP
rs1482387715 1052 dbSNP
rs190325253 1055 dbSNP
rs1349803682 1061 dbSNP
rs1284673216 1063 dbSNP
rs577632670 1067 dbSNP
rs1338537360 1069 dbSNP
rs1333227031 1073 dbSNP
rs900020014 1080 dbSNP
rs1039865667 1081 dbSNP
rs1177816254 1087 dbSNP
rs141508044 1089 dbSNP
rs1375620715 1094 dbSNP
rs1051093505 1095 dbSNP
rs941432739 1105 dbSNP
rs932163492 1111 dbSNP
rs1386475611 1112 dbSNP
rs1457494343 1113 dbSNP
rs1398083115 1119 dbSNP
rs752226204 1127 dbSNP
rs1345945034 1136 dbSNP
rs765215636 1138 dbSNP
rs929979842 1141 dbSNP
rs1298881572 1143 dbSNP
rs545531936 1145 dbSNP
rs1232793259 1148 dbSNP
rs940439568 1152 dbSNP
rs1355864738 1157 dbSNP
rs1285876525 1168 dbSNP
rs578056090 1173 dbSNP
rs1193319962 1174 dbSNP
rs947946803 1198 dbSNP
rs992492804 1201 dbSNP
rs1182009949 1211 dbSNP
rs565522333 1212 dbSNP
rs1411903838 1213 dbSNP
rs753633874 1217 dbSNP
rs960251744 1220 dbSNP
rs1366158366 1226 dbSNP
rs1426470868 1229 dbSNP
rs1291629291 1234 dbSNP
rs762829580 1236 dbSNP
rs1386431344 1237 dbSNP
rs1034285435 1245 dbSNP
rs766103589 1253 dbSNP
rs1307935318 1257 dbSNP
rs553519014 1258 dbSNP
rs78306800 1259 dbSNP
rs1187267708 1271 dbSNP
rs958065212 1273 dbSNP
rs1224406914 1274 dbSNP
rs1465526529 1279 dbSNP
rs368614936 1294 dbSNP
rs774478506 1297 dbSNP
rs764355034 1300 dbSNP
rs1206939783 1322 dbSNP
rs1239564409 1344 dbSNP
rs978188392 1344 dbSNP
rs1021468393 1354 dbSNP
rs574272159 1355 dbSNP
rs771822058 1362 dbSNP
rs763001754 1364 dbSNP
rs1162523419 1369 dbSNP
rs764958057 1382 dbSNP
rs1031444786 1389 dbSNP
rs113889184 1392 dbSNP
rs28548785 1406 dbSNP
rs1283393276 1415 dbSNP
rs1444829866 1423 dbSNP
rs1308690464 1435 dbSNP
rs998450192 1439 dbSNP
rs1435455108 1445 dbSNP
rs770432856 1450 dbSNP
rs1383539190 1452 dbSNP
rs761762857 1461 dbSNP
rs932196512 1474 dbSNP
rs1321519975 1475 dbSNP
rs1228665128 1481 dbSNP
rs1260393837 1485 dbSNP
rs1456215637 1487 dbSNP
rs148332979 1488 dbSNP
rs569327958 1490 dbSNP
rs1483925105 1494 dbSNP
rs1005717085 1500 dbSNP
rs185283566 1504 dbSNP
rs888556716 1507 dbSNP
rs573286448 1516 dbSNP
rs557402305 1524 dbSNP
rs1429015052 1535 dbSNP
rs994637528 1536 dbSNP
rs1172633718 1537 dbSNP
rs1421186664 1546 dbSNP
rs746321718 1549 dbSNP
rs1464272345 1564 dbSNP
rs1166284266 1565 dbSNP
rs28540146 1566 dbSNP
rs56945206 1568 dbSNP
rs565671801 1576 dbSNP
rs1379164847 1582 dbSNP
rs1280507273 1583 dbSNP
rs1450435830 1585 dbSNP
rs28657922 1589 dbSNP
rs916493072 1592 dbSNP
rs938370467 1599 dbSNP
rs926913675 1602 dbSNP
rs980057046 1602 dbSNP
rs914436926 1619 dbSNP
rs1195679102 1620 dbSNP
rs143281676 1627 dbSNP
rs936502403 1631 dbSNP
rs923707367 1645 dbSNP
rs1399149991 1648 dbSNP
rs977887013 1649 dbSNP
rs1031097292 1667 dbSNP
rs1009361744 1670 dbSNP
rs190546637 1674 dbSNP
rs922939438 1675 dbSNP
rs142806385 1686 dbSNP
rs184453996 1691 dbSNP
rs1300545420 1703 dbSNP
rs1029405215 1709 dbSNP
rs77433847 1712 dbSNP
rs1018526506 1716 dbSNP
rs1369361908 1725 dbSNP
rs1217098034 1728 dbSNP
rs1277311889 1732 dbSNP
rs899409297 1743 dbSNP
rs557763431 1753 dbSNP
rs112914866 1754 dbSNP
rs1283736630 1756 dbSNP
rs1344106169 1770 dbSNP
rs1487908671 1770 dbSNP
rs1248228556 1774 dbSNP
rs1326238607 1777 dbSNP
rs1189628553 1778 dbSNP
rs1424591672 1779 dbSNP
rs1420334879 1782 dbSNP
rs563653751 1787 dbSNP
rs952928064 1790 dbSNP
rs1005024637 1791 dbSNP
rs370072511 1793 dbSNP
rs375739319 1795 dbSNP
rs1367850863 1800 dbSNP
rs938430403 1812 dbSNP
rs1273836239 1818 dbSNP
rs1411178197 1819 dbSNP
rs1433594393 1823 dbSNP
rs1306414757 1827 dbSNP
rs1352982992 1828 dbSNP
rs1050120823 1831 dbSNP
rs931665884 1838 dbSNP
rs922938982 1846 dbSNP
rs927014263 1857 dbSNP
rs1291769943 1866 dbSNP
rs906589128 1867 dbSNP
rs1246399551 1875 dbSNP
rs1046422238 1877 dbSNP
rs116137531 1878 dbSNP
rs1180665957 1885 dbSNP
rs371423791 1888 dbSNP
rs75414809 1890 dbSNP
rs1439633992 1892 dbSNP
rs191436876 1893 dbSNP
rs1392465849 1905 dbSNP
rs80111303 1915 dbSNP
rs1403903724 1917 dbSNP
rs1323282405 1918 dbSNP
rs10515642 1941 dbSNP
rs955906121 1954 dbSNP
rs1448528578 1956 dbSNP
rs1328704780 1961 dbSNP
rs747678854 1968 dbSNP
rs1426051151 1984 dbSNP
rs778325665 1985 dbSNP
rs1193019972 1995 dbSNP
rs1487516554 1997 dbSNP
rs912344864 2005 dbSNP
rs543729169 2020 dbSNP
rs576355632 2021 dbSNP
rs1483991679 2030 dbSNP
rs750303287 2035 dbSNP
rs1184010401 2052 dbSNP
rs923008430 2055 dbSNP
rs764220409 2062 dbSNP
rs1457339310 2077 dbSNP
rs996113686 2080 dbSNP
rs78098966 2084 dbSNP
rs1472077176 2087 dbSNP
rs12109481 2097 dbSNP
rs542317316 2103 dbSNP
rs953045306 2105 dbSNP
rs886650439 2112 dbSNP
rs1168046871 2113 dbSNP
rs1025815486 2116 dbSNP
rs770366008 2117 dbSNP
rs1335587329 2118 dbSNP
rs1338701908 2130 dbSNP
rs35180295 2133 dbSNP
rs750220087 2148 dbSNP
rs1057482322 2150 dbSNP
rs12232 2166 dbSNP
rs905591184 2175 dbSNP
rs1319648273 2176 dbSNP
rs970818458 2179 dbSNP
rs1220724369 2183 dbSNP
rs765314740 2190 dbSNP
rs1256338767 2199 dbSNP
rs1044146301 2204 dbSNP
rs187005028 2220 dbSNP
rs1411051476 2229 dbSNP
rs1372937096 2231 dbSNP
rs1441251507 2231 dbSNP
rs1187773665 2244 dbSNP
rs1264386775 2246 dbSNP
rs1012224544 2250 dbSNP
rs556730682 2266 dbSNP
rs1032728265 2268 dbSNP
rs1461760665 2275 dbSNP
rs1422529434 2277 dbSNP
rs1000796503 2290 dbSNP
rs1466230574 2299 dbSNP
rs1173882368 2311 dbSNP
rs902389427 2316 dbSNP
rs1359985716 2324 dbSNP
rs1042262542 2329 dbSNP
rs745917926 2333 dbSNP
rs1298686169 2335 dbSNP
rs763172136 2339 dbSNP
rs1397963153 2342 dbSNP
rs933136850 2356 dbSNP
rs1234218096 2358 dbSNP
rs1257846951 2371 dbSNP
rs901616602 2374 dbSNP
rs1210825891 2375 dbSNP
rs1202453175 2380 dbSNP
rs752734850 2390 dbSNP
rs1489537800 2391 dbSNP
rs912430497 2393 dbSNP
rs1261448499 2400 dbSNP
rs550069664 2401 dbSNP
rs1433421109 2405 dbSNP
rs987024050 2409 dbSNP
rs1038822642 2418 dbSNP
rs538124691 2419 dbSNP
rs933441561 2421 dbSNP
rs538238894 2423 dbSNP
rs1158705712 2425 dbSNP
rs1418379256 2435 dbSNP
rs1249450117 2442 dbSNP
rs1417785572 2448 dbSNP
rs908887343 2465 dbSNP
rs922037202 2466 dbSNP
rs984825793 2466 dbSNP
rs542623985 2467 dbSNP
rs1303613846 2471 dbSNP
rs760147954 2472 dbSNP
rs963352750 2481 dbSNP
rs1310071377 2484 dbSNP
rs138212469 2493 dbSNP
rs972952257 2496 dbSNP
rs78349754 2502 dbSNP
rs1311249835 2506 dbSNP
rs951023158 2506 dbSNP
rs1268279820 2511 dbSNP
rs1035886308 2516 dbSNP
rs1025073241 2519 dbSNP
rs533178913 2524 dbSNP
rs113119595 2531 dbSNP
rs1022729656 2533 dbSNP
rs990875664 2542 dbSNP
rs559758916 2547 dbSNP
rs1459293561 2552 dbSNP
rs1032346727 2556 dbSNP
rs547591203 2559 dbSNP
rs1304957287 2565 dbSNP
rs10476752 2571 dbSNP
rs1021273715 2574 dbSNP
rs997412271 2577 dbSNP
rs1332137600 2584 dbSNP
rs1379118095 2587 dbSNP
rs1238654392 2591 dbSNP
rs10072365 2592 dbSNP
rs1038854029 2593 dbSNP
rs1247498948 2597 dbSNP
rs773621703 2597 dbSNP
rs1198823697 2604 dbSNP
rs1239472301 2608 dbSNP
rs932488892 2616 dbSNP
rs921060691 2620 dbSNP
rs887524198 2622 dbSNP
rs10476941 2630 dbSNP
rs1435278597 2641 dbSNP
rs928950166 2644 dbSNP
rs1416820177 2656 dbSNP
rs576318908 2661 dbSNP
rs1171597229 2669 dbSNP
rs973412641 2679 dbSNP
rs1297653549 2693 dbSNP
rs1380616342 2696 dbSNP
rs564487358 2699 dbSNP
rs1424299014 2700 dbSNP
rs1311048597 2701 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aagucgggucggagcGGACgag 5'
                         ||||   
Target 5' auuuuuauuucacuaCCUG--- 3'
 		7 - 25
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001135644 | 3UTR | UACCUGCUAGAGCCUACUGUGAAAUCACUGCUCCAUAUUUGCCAGUGGAGGAAAUGGGCAUAGAGUAGAGAAUAGCUUCAUAUGUUUACACGUUUGCAUAGACUACACACAUGUCAUGCGUUUAUGGCAGGUAGCUGGUAUUUAUUCCCCAAAGUAAUAAUGUUGAAGUAUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001135644 | 3UTR | AGAGCCUACUGUGAAAUCACUGCUCCAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001135644 | 3UTR | CCUGCUAGAGCCUACUGUGAAAUCACUGCUCCAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001135644 | 3UTR | CACUACCUGCUAGAGCCUACUGUGAAAUCACUGCUCCAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001135644 | 3UTR | CUGCUAGAGCCUACUGUGAAAUCACUGCUCCAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001135644 | 3UTR | CUACCUGCUAGAGCCUACUGUGAAAUCACUGCUCCAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000447998.2 | 3UTR | UCUCAAAUUUUUAUUUCACUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-4690-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071223 FCF1 FCF1, rRNA-processing protein 2 2
MIRT082025 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT144286 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT202048 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT213227 REST RE1 silencing transcription factor 2 6
MIRT445866 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT455955 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT459110 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT460327 SH3RF1 SH3 domain containing ring finger 1 2 2
MIRT461645 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT463497 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT464900 UBALD1 UBA like domain containing 1 2 2
MIRT472262 NFIC nuclear factor I C 2 2
MIRT478028 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT483753 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT485186 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 4
MIRT486550 DCTN4 dynactin subunit 4 2 2
MIRT495087 IGSF3 immunoglobulin superfamily member 3 2 2
MIRT495141 ZNRF1 zinc and ring finger 1 2 2
MIRT501269 NHS NHS actin remodeling regulator 2 4
MIRT503264 KIF18B kinesin family member 18B 2 2
MIRT507165 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512519 BTBD19 BTB domain containing 19 2 2
MIRT528862 PKP1 plakophilin 1 2 2
MIRT546526 SERTAD3 SERTA domain containing 3 2 2
MIRT555058 PYURF PIGY upstream reading frame 2 2
MIRT574028 RIMBP3C RIMS binding protein 3C 2 2
MIRT574106 VASN vasorin 2 2
MIRT630923 UNC93A unc-93 homolog A 2 2
MIRT640178 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT655959 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT659747 CCDC30 coiled-coil domain containing 30 2 2
MIRT666062 STK40 serine/threonine kinase 40 2 2
MIRT670696 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 4
MIRT674196 GJD3 gap junction protein delta 3 2 2
MIRT686948 SFT2D3 SFT2 domain containing 3 2 2
MIRT697466 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT698221 TMEM248 transmembrane protein 248 2 2
MIRT699448 SLC1A5 solute carrier family 1 member 5 2 2
MIRT718999 UTP15 UTP15, small subunit processome component 2 2
MIRT720024 TFAP2C transcription factor AP-2 gamma 2 2
MIRT721530 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4690 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-4690-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4690-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4690-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4690-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4690-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4690-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4690-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4690-5p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4690-5p Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4690-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-4690-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4690-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4690-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4690-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4690-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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