miRTarBase - #MIRT486581


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pre-miRNA Information
pre-miRNA hsa-mir-873   
Genomic Coordinates chr9: 28888879 - 28888955
Synonyms MIRN873, hsa-mir-873, MIR873
Description Homo sapiens miR-873 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-873-3p
Sequence 46| GGAGACUGAUGAGUUCCCGGGA |67
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760528397 3 dbSNP
rs773403294 9 dbSNP
rs1273846238 13 dbSNP
rs1339396073 15 dbSNP
rs1247999695 18 dbSNP
rs377380148 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF619   
Synonyms -
Description zinc finger protein 619
Transcript NM_001145082   
Other Transcripts NM_001145083 , NM_001145093   
Expression
Putative miRNA Targets on ZNF619
3'UTR of ZNF619
(miRNA target sites are highlighted)		 
>ZNF619|NM_001145082|3'UTR
   1 GCCCCGTCACGTTCTCAAAATCCTTTGCACCTCAAGTTAGGGATTCCACTGGTCTCCTGATTGTGTCTATTGATATTCCT
  81 CTGGTCTTGTCTTGTATAAGTTGTTACTGTTTTCCTAACTTCATTTTAAATTCTCACGCTTAAGGACCATGTTTGATTAG
 161 TTTCTTTTATCCCCCGGTAGGAAATGGCAGTACTTATTCTTTATCGTGTCCACATTTGGGCTGTATTATCAGTCTGCATC
 241 TCTCTTCTGGGGCTACTGGAGTTGGAAGAGTTTGCAGAACATTTTGGGGTTTAGGGCATATGGCATTATGATTATGATGA
 321 GATGGGGCATTATAATTAGAGACTAGGAGAAATGCAAAGCCTATGGGAGAACATAATCAGATAAAGTGTCCAATGATTGC
 401 TTTCAAGAGCTTTTTTTTTTTTAGGGGGTGGGGGGTGGTGCCGGAGTTTCACTCTTGTCACCCAGGCTGTTTGCAGTGGT
 481 GTGATCTTGGCTCACTGCAACCTCTGCCTCCAGGGTTCAAGTGATTCTCATGCCTCAGCCTCCCGAGTAGCTGGGACCAC
 561 AGGCATGCACCACCACGCCCCGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAA
 641 AATCCTGACCTCAGGTGATTCACCTGCCTCAGTCTCCCAAGTGCTGGGATTACAGGCATGAGCCACTGCATCTGGCCTGC
 721 TTTCAGGAGTTAAGGAGGGCCATTTGGTGGACCAGGGGCAAGGCTCACTGAAAGAATGTAAGACTTGGAATTTTTTATTA
 801 CCTTGATAGTATAAAAAATTATGAGGGTCCTTTTATGCAAAAAGAAAATGAAGTGATGAGTTGGCATTGATAGCAATAAT
 881 GTAAAATTATGTCTTTGAGCTTTATTGGAAGGGGATATGGTTTTTCAATTTGGGTTCCTTCTCTATTTTCATTTTCCTTT
 961 TTTTTTTGAGACAGGTTCTTGTTCTGTCATCCAGGCTGGATTGCAGTAGTGCGATCATGGATCACTGCAGTGTGTTGACC
1041 TTCCAGGCTCAAGCAATCCTCCCACCTCAGCTTCCCAAGAAGCTGGGAGGTAGTGCAGCCTCCCAGTTTCTCAGAGGGCT
1121 GAGGTGGGAGGATTGCTTGAGCCCTGGGGGCATACACCACCACACCCAGCTAATTTTTGTATTTTTTGTAGAGACAGAGT
1201 TTTGCCATGTTGCCCAGGCTGGTCTCAAAACTCCTGGACTCAAATGATCCTCCCACTTCAGCCTCCCAAAGTGCTGGGAT
1281 TACAGGCTTGAGCCACCATGTCCAGCCTCTATTCCTTTTCATATCTGTTGAATTTCAGTACCCACTCATATATGTAGGTA
1361 CAAAAAGTGACTTGGACTTGTACCCTTTAGGGTAGATGCCTGAGTATAGTAATCTCTAAAGCTGTACATGGATGGAACTT
1441 GTTGGCATCACACTGGTGAGCACCAGAGGCAAAGAAGAGAAACCTGACCATGACTTGCTGTAGTTTCTCAGAAGTGAGTC
1521 CATTCCTGATGAGTTACTATGCAGGCCCTTGGATATGTCCTCACACCTACTCCAGATTTCCCTATGATTAAATCTGAATT
1601 TTATTGGTGGCACTTTTAAATTAGTTTTATAAAGAACTGTTTTGATGACACCAAGAAATGTTTTCAGTGTGCAGATTGCT
1681 ATTGTTTGAATATCCCCAGCAAAATTCTTGTTGAAACTTAATCCCCATTGTAACAGTACTGGGTGGGGGGTCTTTAAGAG
1761 GTGATCAGGATTAGCCAAGTTCATCAGGGTGGAGCCTCCATGATGGGACTGGTGGCTTTATGAGGAGAGGAAGAGCAACT
1841 GGAACTGGGACACATGCTTGCTCTGTCTTGCCTTTTGATGCCTCCTGCCATGTCATGATGCAGCAAGTAAGCCCTTACCA
1921 GATGCCTGCACCTTTATATTGGACTTCTTAGCCTTCAGAACTGTGAACTAAATAAACCTCTATTCTGTATAAATTAAAAA
2001 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGCCCUUGAGU------AGUCAGAGg 5'
            | || :|:|||      |||||||| 
Target 5' ctCAGGTGATTCACCTGCCTCAGTCTCc 3'
 650 - 677 158.00 -22.00
2 
miRNA  3' agGGCCC--UUGAGUAGUCAGAgg 5'
            ::|||  :  |:||||||||  
Target 5' atTTGGGCTGTATTATCAGTCTgc 3'
 214 - 237 138.00 -20.80
3 
miRNA  3' agGGCCCUUGAGUA-GUCAGAGg 5'
            |:||||: | :| ||| ||| 
Target 5' agCTGGGAGGTAGTGCAGCCTCc 3'
 1081 - 1103 132.00 -22.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN27006352 7 COSMIC
COSN228983 12 COSMIC
COSN30151810 17 COSMIC
COSN30468892 24 COSMIC
COSN30473726 26 COSMIC
COSN31509206 52 COSMIC
COSN31514210 68 COSMIC
COSN23016330 87 COSMIC
COSN31596553 119 COSMIC
COSN1083414 133 COSMIC
COSN1083413 134 COSMIC
COSN1083412 184 COSMIC
COSN15661384 253 COSMIC
COSN27312721 423 COSMIC
COSN25014895 933 COSMIC
COSN22736968 936 COSMIC
COSN22859393 1218 COSMIC
COSN25021375 1364 COSMIC
COSN9550831 1740 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1220985974 3 dbSNP
rs1011076170 5 dbSNP
rs115926534 6 dbSNP
rs143276223 7 dbSNP
rs570092063 8 dbSNP
rs760862105 11 dbSNP
rs374778153 12 dbSNP
rs539086718 23 dbSNP
rs374714125 28 dbSNP
rs1178242089 29 dbSNP
rs765647998 34 dbSNP
rs750951068 35 dbSNP
rs777365875 36 dbSNP
rs1444309349 38 dbSNP
rs759038611 41 dbSNP
rs779691807 46 dbSNP
rs369040909 50 dbSNP
rs972176326 55 dbSNP
rs1178402999 58 dbSNP
rs920356678 59 dbSNP
rs1260726542 64 dbSNP
rs532915384 66 dbSNP
rs1208823698 71 dbSNP
rs999099729 84 dbSNP
rs985914244 94 dbSNP
rs570333087 95 dbSNP
rs879940446 97 dbSNP
rs1249433246 98 dbSNP
rs1351403889 104 dbSNP
rs1031506819 121 dbSNP
rs944561043 127 dbSNP
rs965177373 138 dbSNP
rs768769920 139 dbSNP
rs1446134367 146 dbSNP
rs976835538 171 dbSNP
rs535646137 176 dbSNP
rs774125873 177 dbSNP
rs1378967520 188 dbSNP
rs924531281 195 dbSNP
rs935338789 198 dbSNP
rs116143397 207 dbSNP
rs1482731136 214 dbSNP
rs1457772243 222 dbSNP
rs893870426 235 dbSNP
rs1242401014 236 dbSNP
rs1037686203 262 dbSNP
rs1322674978 272 dbSNP
rs1404114451 281 dbSNP
rs928149491 283 dbSNP
rs1246655706 289 dbSNP
rs1323250184 294 dbSNP
rs1011022469 297 dbSNP
rs572714058 317 dbSNP
rs115130932 326 dbSNP
rs1299071582 333 dbSNP
rs1401894193 340 dbSNP
rs1003723577 342 dbSNP
rs1358722648 343 dbSNP
rs1298080930 354 dbSNP
rs199683117 360 dbSNP
rs796537199 361 dbSNP
rs558333395 363 dbSNP
rs1163108186 371 dbSNP
rs80138817 377 dbSNP
rs1195462645 379 dbSNP
rs1419751937 379 dbSNP
rs1228431341 383 dbSNP
rs1476528905 384 dbSNP
rs1261881227 394 dbSNP
rs1223051303 399 dbSNP
rs993162427 408 dbSNP
rs1027763717 409 dbSNP
rs1220512514 411 dbSNP
rs1407914283 411 dbSNP
rs879692096 411 dbSNP
rs1208982921 423 dbSNP
rs1279015937 426 dbSNP
rs998819242 427 dbSNP
rs951729389 429 dbSNP
rs1277658953 430 dbSNP
rs990150783 430 dbSNP
rs543806694 431 dbSNP
rs1175269268 432 dbSNP
rs1407105688 433 dbSNP
rs1355504856 436 dbSNP
rs914635929 437 dbSNP
rs562591742 444 dbSNP
rs1161348820 455 dbSNP
rs1463743496 458 dbSNP
rs1427257657 470 dbSNP
rs1422216420 475 dbSNP
rs1469418248 479 dbSNP
rs1199497312 490 dbSNP
rs1434436523 491 dbSNP
rs997951140 494 dbSNP
rs576306289 503 dbSNP
rs151269066 513 dbSNP
rs1480811704 516 dbSNP
rs1361129764 520 dbSNP
rs1259757036 523 dbSNP
rs1200695348 525 dbSNP
rs976353987 527 dbSNP
rs561905122 531 dbSNP
rs934595461 533 dbSNP
rs1052432227 535 dbSNP
rs1332959474 537 dbSNP
rs1299758726 539 dbSNP
rs773110608 540 dbSNP
rs1386740285 542 dbSNP
rs1378027634 543 dbSNP
rs527510919 545 dbSNP
rs915215597 546 dbSNP
rs1399050448 550 dbSNP
rs1172846775 559 dbSNP
rs1467085139 561 dbSNP
rs1412184180 564 dbSNP
rs946715304 571 dbSNP
rs547081462 577 dbSNP
rs1167059523 578 dbSNP
rs765180143 582 dbSNP
rs973006705 583 dbSNP
rs1202116948 594 dbSNP
rs1201271132 609 dbSNP
rs928182194 611 dbSNP
rs1233092356 612 dbSNP
rs866829793 619 dbSNP
rs1003714393 620 dbSNP
rs1057059732 632 dbSNP
rs1444994634 634 dbSNP
rs898065589 656 dbSNP
rs1334353406 658 dbSNP
rs182609551 688 dbSNP
rs765868565 690 dbSNP
rs1419849836 692 dbSNP
rs1027926142 695 dbSNP
rs1382061539 697 dbSNP
rs1156830556 698 dbSNP
rs915668507 701 dbSNP
rs1368867202 726 dbSNP
rs887404947 738 dbSNP
rs1188431966 744 dbSNP
rs138793821 752 dbSNP
rs1254410181 754 dbSNP
rs1199941516 760 dbSNP
rs1427480556 764 dbSNP
rs1007188744 788 dbSNP
rs1017300354 792 dbSNP
rs1353352932 802 dbSNP
rs1285168049 813 dbSNP
rs187264488 815 dbSNP
rs140518106 819 dbSNP
rs975921239 822 dbSNP
rs904217783 824 dbSNP
rs868563441 827 dbSNP
rs1333142593 841 dbSNP
rs934303021 845 dbSNP
rs1361925523 853 dbSNP
rs549771148 854 dbSNP
rs1419027909 862 dbSNP
rs990446893 866 dbSNP
rs570220442 867 dbSNP
rs753404820 872 dbSNP
rs1164770232 873 dbSNP
rs1471728710 874 dbSNP
rs191840370 891 dbSNP
rs549436895 894 dbSNP
rs1215009681 907 dbSNP
rs1435071367 913 dbSNP
rs1488241574 914 dbSNP
rs75248977 915 dbSNP
rs751913994 916 dbSNP
rs1354745523 920 dbSNP
rs1369164562 924 dbSNP
rs757587432 935 dbSNP
rs1310000814 941 dbSNP
rs1341764305 946 dbSNP
rs867262842 951 dbSNP
rs535278898 952 dbSNP
rs1275776308 956 dbSNP
rs1398916089 957 dbSNP
rs1325494237 958 dbSNP
rs1331610395 958 dbSNP
rs1403337815 959 dbSNP
rs558245866 961 dbSNP
rs1056566440 967 dbSNP
rs961423204 972 dbSNP
rs1466346806 975 dbSNP
rs1207057483 976 dbSNP
rs1475149271 979 dbSNP
rs1247777307 987 dbSNP
rs1201676295 990 dbSNP
rs1323100617 1003 dbSNP
rs1450195899 1008 dbSNP
rs530079077 1013 dbSNP
rs1198823823 1014 dbSNP
rs1450998434 1016 dbSNP
rs578149117 1018 dbSNP
rs1217456193 1030 dbSNP
rs1248507532 1041 dbSNP
rs537023855 1043 dbSNP
rs1276498343 1048 dbSNP
rs766082566 1051 dbSNP
rs1188151732 1054 dbSNP
rs929493532 1062 dbSNP
rs541822206 1066 dbSNP
rs1448804495 1071 dbSNP
rs750933016 1080 dbSNP
rs1168861997 1088 dbSNP
rs888063330 1091 dbSNP
rs1007177359 1094 dbSNP
rs1425999403 1095 dbSNP
rs1174758579 1098 dbSNP
rs756755264 1100 dbSNP
rs916789685 1107 dbSNP
rs1252991750 1114 dbSNP
rs1406435530 1117 dbSNP
rs946863916 1118 dbSNP
rs901580629 1123 dbSNP
rs1235960224 1129 dbSNP
rs978559853 1134 dbSNP
rs1312192348 1139 dbSNP
rs997644092 1144 dbSNP
rs1217024071 1145 dbSNP
rs560217165 1150 dbSNP
rs1309936340 1152 dbSNP
rs956026092 1153 dbSNP
rs1374415640 1159 dbSNP
rs1329514183 1160 dbSNP
rs934357188 1163 dbSNP
rs990005633 1166 dbSNP
rs1336234685 1169 dbSNP
rs1052686962 1174 dbSNP
rs901099061 1181 dbSNP
rs1159839331 1182 dbSNP
rs1021550924 1192 dbSNP
rs1378853155 1193 dbSNP
rs1049624186 1199 dbSNP
rs1296348435 1200 dbSNP
rs969988475 1201 dbSNP
rs980756836 1207 dbSNP
rs1207373994 1210 dbSNP
rs1485086373 1212 dbSNP
rs1286587637 1214 dbSNP
rs1218743988 1217 dbSNP
rs1230290372 1219 dbSNP
rs1312674824 1220 dbSNP
rs9862493 1221 dbSNP
rs1380162516 1223 dbSNP
rs1286219757 1226 dbSNP
rs897201319 1233 dbSNP
rs374269373 1235 dbSNP
rs1422071581 1248 dbSNP
rs573986178 1263 dbSNP
rs992613457 1264 dbSNP
rs1035059362 1287 dbSNP
rs1158826112 1288 dbSNP
rs542086527 1289 dbSNP
rs1415480553 1293 dbSNP
rs1208190448 1296 dbSNP
rs929457781 1298 dbSNP
rs1474571744 1301 dbSNP
rs1049257640 1310 dbSNP
rs1248831562 1317 dbSNP
rs1487261081 1320 dbSNP
rs1260143377 1321 dbSNP
rs1466436883 1323 dbSNP
rs1323338157 1325 dbSNP
rs1182028639 1330 dbSNP
rs888010872 1338 dbSNP
rs943652211 1339 dbSNP
rs1039273965 1341 dbSNP
rs991100825 1343 dbSNP
rs1368222537 1344 dbSNP
rs1473370234 1350 dbSNP
rs1165497363 1353 dbSNP
rs1278903630 1354 dbSNP
rs1401994686 1361 dbSNP
rs1406446254 1362 dbSNP
rs1024290067 1366 dbSNP
rs901479928 1372 dbSNP
rs1352014194 1373 dbSNP
rs968264041 1381 dbSNP
rs997193176 1382 dbSNP
rs1436804407 1385 dbSNP
rs66841330 1392 dbSNP
rs891584691 1401 dbSNP
rs571869055 1402 dbSNP
rs6762251 1405 dbSNP
rs1476578938 1409 dbSNP
rs1245260452 1419 dbSNP
rs1285814312 1426 dbSNP
rs1157218431 1427 dbSNP
rs934371563 1429 dbSNP
rs1489319496 1430 dbSNP
rs1244774294 1431 dbSNP
rs1212896397 1434 dbSNP
rs1348494090 1440 dbSNP
rs988516325 1443 dbSNP
rs1021499568 1448 dbSNP
rs1268827534 1449 dbSNP
rs922306092 1456 dbSNP
rs779022982 1459 dbSNP
rs1370110269 1465 dbSNP
rs563809280 1469 dbSNP
rs933644145 1473 dbSNP
rs1207905121 1475 dbSNP
rs532877503 1483 dbSNP
rs1400535500 1494 dbSNP
rs1049687917 1500 dbSNP
rs969894754 1510 dbSNP
rs911103643 1513 dbSNP
rs1001429651 1515 dbSNP
rs1176624691 1529 dbSNP
rs1035609856 1544 dbSNP
rs1434819215 1548 dbSNP
rs1265259479 1558 dbSNP
rs960958635 1575 dbSNP
rs1255811729 1588 dbSNP
rs1238960788 1594 dbSNP
rs992206784 1595 dbSNP
rs1200763868 1596 dbSNP
rs1479675967 1597 dbSNP
rs1443298230 1600 dbSNP
rs919332635 1613 dbSNP
rs950852867 1621 dbSNP
rs1038575363 1631 dbSNP
rs762635070 1644 dbSNP
rs1301967670 1653 dbSNP
rs1231630969 1656 dbSNP
rs543186113 1657 dbSNP
rs748450079 1659 dbSNP
rs896985505 1678 dbSNP
rs984910654 1682 dbSNP
rs909355999 1695 dbSNP
rs1302890001 1701 dbSNP
rs1467197463 1720 dbSNP
rs1393182739 1731 dbSNP
rs563270948 1731 dbSNP
rs528925484 1738 dbSNP
rs943557178 1746 dbSNP
rs1180692823 1748 dbSNP
rs1023903252 1750 dbSNP
rs1039219961 1760 dbSNP
rs796773886 1762 dbSNP
rs1458422385 1770 dbSNP
rs923552906 1773 dbSNP
rs1031625000 1774 dbSNP
rs771821165 1775 dbSNP
rs570929714 1777 dbSNP
rs1396349728 1788 dbSNP
rs1354811407 1790 dbSNP
rs1335960039 1793 dbSNP
rs549640097 1796 dbSNP
rs1011305106 1798 dbSNP
rs6599105 1802 dbSNP
rs922337183 1808 dbSNP
rs905655376 1810 dbSNP
rs1001377246 1818 dbSNP
rs770868791 1825 dbSNP
rs1373102257 1831 dbSNP
rs528652406 1834 dbSNP
rs1362431845 1836 dbSNP
rs1156561790 1840 dbSNP
rs1469497206 1844 dbSNP
rs1363423704 1847 dbSNP
rs1188521518 1854 dbSNP
rs1425561817 1856 dbSNP
rs1255530357 1860 dbSNP
rs1221780455 1868 dbSNP
rs1488888196 1872 dbSNP
rs960023436 1873 dbSNP
rs955057316 1874 dbSNP
rs1350429870 1878 dbSNP
rs1013985434 1896 dbSNP
rs1246575774 1908 dbSNP
rs1026341888 1925 dbSNP
rs1346015804 1927 dbSNP
rs911147978 1928 dbSNP
rs754404509 1929 dbSNP
rs941233542 1931 dbSNP
rs950732191 1933 dbSNP
rs776140576 1942 dbSNP
rs145788921 1945 dbSNP
rs1164006906 1952 dbSNP
rs1056580786 1957 dbSNP
rs1416016830 1966 dbSNP
rs1164303544 1978 dbSNP
rs909301834 1980 dbSNP
rs1478224768 1986 dbSNP
rs896543916 1999 dbSNP
rs1191674469 2003 dbSNP
rs964813376 2004 dbSNP
rs1254609336 2008 dbSNP
rs759001207 2014 dbSNP
rs1473247209 2019 dbSNP
rs1196166139 2024 dbSNP
rs1218695512 2026 dbSNP
rs1376663984 2035 dbSNP
rs1319401976 2039 dbSNP
rs1268276963 2050 dbSNP
rs1429971927 2064 dbSNP
rs1331419966 2067 dbSNP
rs1012257982 2091 dbSNP
rs1438533328 2096 dbSNP
rs1392543370 2113 dbSNP
rs1164500639 2118 dbSNP
rs1045432995 2131 dbSNP
rs1421782122 2135 dbSNP
rs1166615997 2137 dbSNP
rs1475361675 2141 dbSNP
rs923501586 2145 dbSNP
rs933618606 2147 dbSNP
rs1053795873 2154 dbSNP
rs1467460557 2156 dbSNP
rs1251926005 2163 dbSNP
rs1031239552 2164 dbSNP
rs1439000892 2202 dbSNP
rs1270297191 2215 dbSNP
rs184385662 2227 dbSNP
rs947039411 2228 dbSNP
rs1042793181 2231 dbSNP
rs1427515243 2233 dbSNP
rs138451797 2236 dbSNP
rs1029377757 2238 dbSNP
rs143013771 2244 dbSNP
rs985143389 2262 dbSNP
rs1356547509 2286 dbSNP
rs910915280 2289 dbSNP
rs557202678 2291 dbSNP
rs1409525956 2293 dbSNP
rs567648739 2294 dbSNP
rs536259757 2300 dbSNP
rs1176093595 2303 dbSNP
rs974423752 2307 dbSNP
rs895707623 2313 dbSNP
rs1178811366 2315 dbSNP
rs555194488 2316 dbSNP
rs568766461 2329 dbSNP
rs1230855953 2334 dbSNP
rs929808479 2340 dbSNP
rs1442513517 2358 dbSNP
rs994070055 2359 dbSNP
rs1026000543 2373 dbSNP
rs1208681846 2374 dbSNP
rs536256277 2384 dbSNP
rs948176219 2386 dbSNP
rs1170253776 2391 dbSNP
rs1375794528 2393 dbSNP
rs1006183109 2394 dbSNP
rs1045147059 2399 dbSNP
rs1441493720 2404 dbSNP
rs1315306132 2405 dbSNP
rs903880262 2405 dbSNP
rs1016293710 2408 dbSNP
rs572029372 2412 dbSNP
rs964803541 2417 dbSNP
rs1375422871 2419 dbSNP
rs975305747 2423 dbSNP
rs1402873054 2443 dbSNP
rs1030472567 2448 dbSNP
rs61234363 2450 dbSNP
rs749548691 2450 dbSNP
rs1268712079 2453 dbSNP
rs779292706 2454 dbSNP
rs868203187 2455 dbSNP
rs1259036211 2462 dbSNP
rs1206317326 2472 dbSNP
rs989039936 2484 dbSNP
rs1286735771 2485 dbSNP
rs1490008291 2490 dbSNP
rs1217662183 2491 dbSNP
rs1314922639 2493 dbSNP
rs913495347 2495 dbSNP
rs540791453 2500 dbSNP
rs1433333302 2513 dbSNP
rs1200531832 2515 dbSNP
rs1413053548 2521 dbSNP
rs978463893 2524 dbSNP
rs1129200 2526 dbSNP
rs1448580198 2529 dbSNP
rs1018007885 2533 dbSNP
rs1343837607 2534 dbSNP
rs1157856921 2535 dbSNP
rs1405571666 2538 dbSNP
rs1419628247 2542 dbSNP
rs937101712 2547 dbSNP
rs1372277256 2552 dbSNP
rs1057297201 2554 dbSNP
rs577787347 2567 dbSNP
rs1456313426 2569 dbSNP
rs929801008 2573 dbSNP
rs1292911739 2578 dbSNP
rs1162167090 2579 dbSNP
rs962713485 2580 dbSNP
rs973736119 2592 dbSNP
rs1388658602 2596 dbSNP
rs1046939430 2616 dbSNP
rs888395900 2617 dbSNP
rs992074874 2618 dbSNP
rs1222088994 2621 dbSNP
rs1335680308 2623 dbSNP
rs1275353026 2628 dbSNP
rs543498265 2629 dbSNP
rs1006174625 2632 dbSNP
rs1295589416 2636 dbSNP
rs947898826 2651 dbSNP
rs1364770309 2656 dbSNP
rs145168066 2658 dbSNP
rs925366760 2666 dbSNP
rs900524882 2671 dbSNP
rs996254824 2673 dbSNP
rs1396206041 2678 dbSNP
rs1323497981 2680 dbSNP
rs138362463 2684 dbSNP
rs533621492 2688 dbSNP
rs149250446 2693 dbSNP
rs1426638908 2694 dbSNP
rs1418759828 2703 dbSNP
rs1191550129 2715 dbSNP
rs1051956022 2719 dbSNP
rs1255052935 2720 dbSNP
rs118167434 2721 dbSNP
rs1468054960 2724 dbSNP
rs889309022 2725 dbSNP
rs1008343389 2736 dbSNP
rs1018456602 2738 dbSNP
rs1295569545 2748 dbSNP
rs968982590 2749 dbSNP
rs1300753336 2758 dbSNP
rs1439733937 2759 dbSNP
rs1396826276 2761 dbSNP
rs898211063 2762 dbSNP
rs995174349 2764 dbSNP
rs1353840678 2765 dbSNP
rs1488487486 2771 dbSNP
rs879442396 2773 dbSNP
rs926916078 2774 dbSNP
rs750826825 2778 dbSNP
rs1192831970 2785 dbSNP
rs992104274 2786 dbSNP
rs992551649 2794 dbSNP
rs1024879065 2797 dbSNP
rs1464180340 2799 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agggcccuugaguagucAGAGg 5'
                           |||| 
Target 5' -----------cccuccUCUCc 3'
 		1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000447116.2 | 3UTR | CCCUCCUCUCCCCUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081178 MIDN midnolin 2 4
MIRT109809 ZFX zinc finger protein, X-linked 2 4
MIRT242383 TMC5 transmembrane channel like 5 2 4
MIRT444003 METRN meteorin, glial cell differentiation regulator 2 4
MIRT444097 SEPHS1 selenophosphate synthetase 1 2 2
MIRT446158 RPL12 ribosomal protein L12 2 2
MIRT446859 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT447275 FZD5 frizzled class receptor 5 2 2
MIRT447391 TMPRSS15 transmembrane protease, serine 15 2 2
MIRT448817 FKBP1A FK506 binding protein 1A 2 4
MIRT450582 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT451776 USP36 ubiquitin specific peptidase 36 2 2
MIRT457961 ABCC5 ATP binding cassette subfamily C member 5 2 4
MIRT458424 KLHL38 kelch like family member 38 2 4
MIRT461383 SLFN12L schlafen family member 12 like 2 2
MIRT467793 SLC2A14 solute carrier family 2 member 14 2 2
MIRT476517 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT480290 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT482745 HES7 hes family bHLH transcription factor 7 2 10
MIRT483189 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT486545 DCTN4 dynactin subunit 4 2 2
MIRT486581 ZNF619 zinc finger protein 619 2 2
MIRT492604 POLR3E RNA polymerase III subunit E 2 2
MIRT494130 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT496023 ZBED3 zinc finger BED-type containing 3 2 2
MIRT497121 NBEAL1 neurobeachin like 1 2 2
MIRT497400 TMEM245 transmembrane protein 245 2 2
MIRT501410 RANBP10 RAN binding protein 10 2 2
MIRT510947 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT512494 ARID2 AT-rich interaction domain 2 2 2
MIRT512595 ZNF783 zinc finger family member 783 2 2
MIRT512612 CNTN4 contactin 4 2 2
MIRT517808 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT520686 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT526179 HEPH hephaestin 2 2
MIRT532568 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT533979 TADA2A transcriptional adaptor 2A 2 2
MIRT538622 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539703 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539806 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT540422 FAM83F family with sequence similarity 83 member F 2 2
MIRT540506 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540619 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT542423 ZNF331 zinc finger protein 331 2 2
MIRT542454 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT543383 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT544777 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT544923 ERCC4 ERCC excision repair 4, endonuclease catalytic subunit 2 2
MIRT549768 ZNF611 zinc finger protein 611 2 4
MIRT551242 COLEC10 collectin subfamily member 10 2 2
MIRT560474 ENSA endosulfine alpha 2 2
MIRT569738 GPR173 G protein-coupled receptor 173 2 2
MIRT571297 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT572345 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT573112 ERBB2IP erbb2 interacting protein 2 2
MIRT607744 ANGPT4 angiopoietin 4 2 2
MIRT607903 SPRYD4 SPRY domain containing 4 2 2
MIRT611744 SERPING1 serpin family G member 1 2 4
MIRT615101 BNC2 basonuclin 2 2 2
MIRT619124 CD40LG CD40 ligand 2 2
MIRT625572 ANKRD42 ankyrin repeat domain 42 2 2
MIRT629038 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633986 SLC35E2 solute carrier family 35 member E2 2 2
MIRT635675 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637471 DEFB105B defensin beta 105B 2 4
MIRT637503 DEFB105A defensin beta 105A 2 4
MIRT639735 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT640730 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT645364 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT647938 RNF152 ring finger protein 152 2 2
MIRT649400 SH2D4A SH2 domain containing 4A 2 2
MIRT656860 KIN Kin17 DNA and RNA binding protein 2 2
MIRT663470 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT663507 NKAPL NFKB activating protein like 2 4
MIRT667690 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT677403 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT678682 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT678789 NUPL2 nucleoporin like 2 2 2
MIRT680649 KIAA1456 KIAA1456 2 2
MIRT682450 MTX3 metaxin 3 2 2
MIRT682740 CA6 carbonic anhydrase 6 2 2
MIRT684421 TUFT1 tuftelin 1 2 2
MIRT690535 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT690595 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690771 PLA2G2C phospholipase A2 group IIC 2 2
MIRT692233 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT693667 MXRA7 matrix remodeling associated 7 2 2
MIRT695551 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695870 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT696214 LYZ lysozyme 2 2
MIRT698368 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT700795 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT701640 MYLK3 myosin light chain kinase 3 2 2
MIRT702989 HERPUD2 HERPUD family member 2 2 2
MIRT703627 FBXL3 F-box and leucine rich repeat protein 3 2 2
MIRT703783 FAM102B family with sequence similarity 102 member B 2 2
MIRT704293 DDX19B DEAD-box helicase 19B 2 2
MIRT704828 CDC73 cell division cycle 73 2 2
MIRT705014 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT708480 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT710770 PHF7 PHD finger protein 7 2 2
MIRT718918 TRIM66 tripartite motif containing 66 2 2
MIRT720390 ZNF549 zinc finger protein 549 2 2
MIRT720593 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT723515 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724458 PRKX protein kinase, X-linked 2 2
MIRT737267 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 3 0
MIRT737356 ZIC2 Zic family member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-873 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-873 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-873 Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-873 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-873-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-873-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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