| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-497 |
| Genomic Coordinates | chr17: 7017911 - 7018022 |
| Synonyms | MIRN497, hsa-mir-497, MIR497 |
| Description | Homo sapiens miR-497 stem-loop |
| Comment | None |
| RNA Secondary Structure |  |
| Associated Diseases |  |
| Mature miRNA Information | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mature miRNA | hsa-miR-497-3p | ||||||||||||||||||||||||||||
| Sequence | 64| CAAACCACACUGUGGUGUUAGA |85 | ||||||||||||||||||||||||||||
| Evidence | Experimental | ||||||||||||||||||||||||||||
| Experiments | Cloned | ||||||||||||||||||||||||||||
| Editing Events in miRNAs |
|
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| SNPs in miRNA |
|
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| Putative Targets | |||||||||||||||||||||||||||||
| miRNA Expression profile | |
|---|---|
| Human miRNA Tissue Atlas | |
| Circulating MicroRNA Expression Profiling | |
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | ZNF398 | ||||||||||||||||||||
| Synonyms | P51, P71, ZER6 | ||||||||||||||||||||
| Description | zinc finger protein 398 | ||||||||||||||||||||
| Transcript | NM_020781 | ||||||||||||||||||||
| Other Transcripts | NM_170686 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on ZNF398 | |||||||||||||||||||||
| 3'UTR of ZNF398 (miRNA target sites are highlighted) |
>ZNF398|NM_020781|3'UTR 1 ATCCAAATCTCTGTGGCTTCATGCTTGTATATGCTCACAGCAGGGCACAAAATCCAAGAGAAGGTCTGTGAGCCCCATCC 81 AACACCCACAGTAATTATTATCTGGCACATCAATGAATTTGGGGTCCTATACACTTGACTAGAGACATGCTTGTGTTTTG 161 GAATTTCACACCCTTACAAGAATACCACATTTTGAAACCCAGAAAGACCTGGAAAGGAGCCCAGCATGTCCATCTTTTCA 241 AAGATACAACAAAAGCAGAAGTTACAAGAATATTGCGGAGAGGTTGGAAAGCAGGATTTAACCTCTAGTTCTCTTGTTCT 321 CAGAGAACAGCAGGTTGATAGTAGATTATGTCTCTAGGTAGAGACAGATACATGAGAAGAGCCTCCAAAACTGGAAGCCC 401 ATCATAAGGCATGAGAATGTTTAACTATAAAGCCTTTTATTAGTTCTTTGATAGCTAAGATGGTTGTTGGAGAAAGTGCT 481 TAAGCCACTGTTTATGTTGCTGCCTCCTCTCTCAAAACCAGCCAAGATCTGTTCACACACCTCTGTGGCTGTCTTTCCCT 561 GAAACATGGTAACTCAAGACTGCCTGCCTAGGTTTCTTAGATTAATTATTCACATAAATTTTGTTTAATATTGGTTGAAC 641 AAGAAATCTGACTTTAAAAGATTATTAAGGAGAATATTCCTTAACTATACTGGCTTGATTTGAAACAGGCTCTTATTGCC 721 ATTTAAACTGCCAGAAATCTTTGCCAAGGTCCTGGTTAAAAAAATTGGAAACGGTTTTCTTAGCCCCAGCTTTAAAAGCT 801 AGAGATCTCAGAGAAATAGCTGGCTTAACAATGACAGAACAGCTTAAAATTTGTGCCTACACCATGTTCTGAGAGTCGTT 881 CACATCAAATTCTTATCTTTTCCAAGCCAGTAAGTTGGCTTCTCCATTCCTGGTGTCTGATATTCTTGACAATCATCAGC 961 AACAAAGATCACAGCACTTTCCAGAAGCATGGAGCTTCAGAAAGTGCCAGTGAACTCTTGGTCCTCAGTAGTGAGATGAT 1041 AACAGTGTTATAATGCAGCTTCCTTGAGCCATCAGAGAGAGTGTATGTTCACCCTATCTGGCTGTATCCCATTGGCAGTG 1121 GACAGATTGAGGAAATTCCTAGATCACTGAGAGCTAAGCACCATGCATAGACAACAGTTTGTTCTTGCCTGTGTTGCTTT 1201 TAGGGACTTTGACTACCACATGTTCTTTTCTTGGGGTGATTTAATCACCTGGGAGCATCTGAGTCTGCTCCTAAGTGGCT 1281 TTGCAACTGGGCCTAAGTTCTGTTTCCTTTATGGATCTCAAATTTTCATCTGCACAATGAGGCTGTTGAAAGGAAAAAAA 1361 GTGAGCCTCTAGGAATTATTCAAAAAAAGTCTGTGATACATTCCTTTTCCTGCCAAAGTTCTGTCTCTGTCTTTGGCTTC 1441 TGTCCAGGCAAAGCTAAATAAGACAGCAAAGTCAAAGCAGATAAATTCTTGTTGAAACTTGACTAAAATTTATTTGATTT 1521 GTTGTTTTACTCCCACTTGGAATCCTGAGGTAGAAGACAGAATGCAGAAGTCTTACATCTTGGGCAGGAAACTGGTTTAT 1601 TCCTATACTCTTGTTTCCTCTGCTTCTTCCTGAGGTCTAGAACAAGGTCTGGAAATGTTTAGACAGGATATTTTCTTGAT 1681 GAAGTGATAAGGAAAGGACCCATTTTTTTGCTCATCACCTAGCCCATCCTTCACTCTCTCTAGTTATGCATAACAACACT 1761 AGAAGAAGGTGTTAGCCCAGCTAACTTTGCTTCTGGGAAGGCTATGTCTGAACATGTTGCTCTGTAGGATAATCACACTT 1841 AGAAAACATCTGCTCCATGACATTCACAATACCAGGGACCATGGGAGACACAAGAAATGTGTGTCTGCTGTCATAACTTA 1921 CAGTGAAAAAGCCCAATAATACAGAACAAGACATGATGGGCAATACCCTAGCATATTGGGATTAAGAGCTTTCTAGCCAG 2001 AATCTGGACCTATACCATGGGAAAATTTAGGGGTGCTGGGAATCCCAAAGCCAAGGTTCTGGCTTCATTGGCAACCCACT 2081 AGGAACTTGAATGTGAGATTCAGCTCTAGTTTGCACCTTGATTTCCCCAGTGAAAAGGGAGAAGAGCCAAAGTATTGTCT 2161 AGGTGCTGAGTTCCCTTTTCTGAGTGGATTTCAAGCATTTGCCAGGGTATGCTGGAGGAGGGACTCCTAAAGTAGGTGAG 2241 ATGTGGGACTAGGTAACACTTTAAATACTTTTTTACTCAAAGATTTGCCAAGAACACAGCTTATTAGTGAAAGAGACCTG 2321 TGGATTGAAATGGCTGCAGATAGATCCCGCAGTCCCTTCTGAAAGGAACTGTGTAGCCAGCAGGGACCTAAACTTTGGCA 2401 AAAAGTGAACACAATTCAAATACGAATGAAGGAAGAGCCCTCAGATGGAACGAAAGGCGATGTGCAAGGCCATCCCAGAG 2481 AGACGGAAGCAGGTGCGATACTAAGCCTCAGCCCAAGAATAAAAGAGAGTTCAACTGTTACTCTTTTCTTTCATCAATCC 2561 CCTATCAGTTAGAACTGCAGGCCAGTTCCAAAGAGTGTTTGCTTAAGATTCAAAAGTGGGTAAGTAAAATGGATCAGTGG 2641 GAAGGATAAGGTGTCCAACAGAAAGTGTGGAGGAGAAACTCTTGGCCTATCAAGTGCTCCTGAGAGAAACCATGCAATTT 2721 AACACTTCAGTTAAAGAAATACATGAGAACTGCTTGTCATGACCAGACAAGATAGGAAAGGGGAAACCCCAGAAACGTGC 2801 TCTTCATCTGTCAGCCTTTTGGACCAAGAAGCTGTCACTATCACACATAAGCACCATTCCCTTAGAGTGGATCCAGGTGT 2881 TGACTATAACCAGATTTACTCTTTGCTTACTAGGTTTTCCATTGTCACCATTGGATGAACCTCTGGTTTAGCCACAGTTG 2961 TGAAAATAAATGGAAGTTGGTTGATTGTCTAGAAAGTGCAAGAAGATGGCCCTGCTCCTTTTCTGCTGAACATTTAGTAT 3041 TGGAAACTCCTACTTCCCTTTTCATTAATAATGTGTGCAAGTTTCCTATTAGCGGGGAAGGTGTGGGGCTCTGCTGGGCT 3121 TCTCTTGAGCATATCTGAGAAGTGATGTTCATGTCTATCTCAACCAGGACCAGACCCTGTGACTTACTCGGTAATAACAG 3201 TCCACACAAGCCTCGTTGATATTAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
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| miRNA-target interactions (Predicted by miRanda) |
|
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| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
|---|---|---|---|---|---|---|---|
| miRNA:Target | ---- | ||||||
| Validation Method |
|
||||||
| Conditions | HEK293 | ||||||
| Location of target site | 3'UTR | ||||||
| Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control
PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
||||||
| miRNA-target interactions (Provided by authors) |
|
||||||
| Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
||||||
| Experimental Support 2 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | hESCs (WA-09) |
| Disease | 57541.0 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
| Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
|
| Experimental Support 3 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | C8166 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3
... - Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio. |
| Article |
- Whisnant AW; Bogerd HP; Flores O; Ho P; et al. - mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
|
| Experimental Support 4 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HCT116 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5
PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5
PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5
... - Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research. |
| Article |
- Krell J; Stebbing J; Carissimi C; Dabrowska et al. - Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
|
| CLIP-seq Support 1 for dataset GSM545213 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / Control |
| Location of target site | ENST00000420008.2 | 3UTR | UUGGAUGAACCUCUGGUUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 2 for dataset GSM545215 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO4 |
| Cell line / Condition | HEK293 / Control |
| Location of target site | ENST00000420008.2 | 3UTR | AUUGGAUGAACCUCUGGUUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 3 for dataset SRR359787 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
| Location of target site | ENST00000420008.2 | 3UTR | UCACCAUUGGAUGAACCUCUGGUUUA |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 22012620 / SRX103431 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 4 for dataset GSM1462572 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | C8166 / C8166 NL4-3 |
| Location of target site | ENST00000420008.2 | 3UTR | UGGAUGAACCUCUGGUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 23592263 / GSE59944 |
| CLIP-seq Viewer | Link |
| MiRNA-Target Expression Profile | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT092955 | CYP2U1 | cytochrome P450 family 2 subfamily U member 1 |  |
|
2 | 4 | ||||||
| MIRT124568 | PRRC2B | proline rich coiled-coil 2B | |
|
2 | 2 | ||||||
| MIRT125196 | EIF1AX | eukaryotic translation initiation factor 1A, X-linked | |
|
2 | 4 | ||||||
| MIRT147296 | KPNA2 | karyopherin subunit alpha 2 | |
|
2 | 8 | ||||||
| MIRT163999 | KIAA1109 | KIAA1109 | |
|
2 | 4 | ||||||
| MIRT252495 | NWD1 | NACHT and WD repeat domain containing 1 | |
|
2 | 2 | ||||||
| MIRT357969 | GRPEL2 | GrpE like 2, mitochondrial | |
|
2 | 2 | ||||||
| MIRT443007 | TRIOBP | TRIO and F-actin binding protein | |
|
2 | 2 | ||||||
| MIRT443524 | NETO1 | neuropilin and tolloid like 1 | |
|
2 | 2 | ||||||
| MIRT443573 | EVX2 | even-skipped homeobox 2 | |
|
2 | 2 | ||||||
| MIRT443656 | BACH1 | BTB domain and CNC homolog 1 | |
|
2 | 2 | ||||||
| MIRT460670 | KRT10 | keratin 10 | |
|
2 | 8 | ||||||
| MIRT464761 | UBE2N | ubiquitin conjugating enzyme E2 N | |
|
2 | 2 | ||||||
| MIRT465032 | LINC00598 | long intergenic non-protein coding RNA 598 | |
|
2 | 2 | ||||||
| MIRT465040 | TTC39C | tetratricopeptide repeat domain 39C | |
|
2 | 2 | ||||||
| MIRT468667 | SEC62 | SEC62 homolog, preprotein translocation factor | |
|
2 | 2 | ||||||
| MIRT473694 | MAPK8 | mitogen-activated protein kinase 8 | |
|
2 | 4 | ||||||
| MIRT477618 | EFNA3 | ephrin A3 | |
|
2 | 2 | ||||||
| MIRT480506 | C11orf57 | chromosome 11 open reading frame 57 | |
|
2 | 2 | ||||||
| MIRT480592 | BUB3 | BUB3, mitotic checkpoint protein | |
|
2 | 2 | ||||||
| MIRT486915 | ZNF398 | zinc finger protein 398 | |
|
2 | 6 | ||||||
| MIRT487770 | ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | |
|
2 | 16 | ||||||
| MIRT493265 | MDFIC | MyoD family inhibitor domain containing | |
|
2 | 2 | ||||||
| MIRT495271 | SLC1A2 | solute carrier family 1 member 2 | |
|
2 | 4 | ||||||
| MIRT495309 | CHST12 | carbohydrate sulfotransferase 12 | |
|
2 | 2 | ||||||
| MIRT496681 | DPP6 | dipeptidyl peptidase like 6 | |
|
2 | 4 | ||||||
| MIRT496891 | FOXP1 | forkhead box P1 | |
|
2 | 2 | ||||||
| MIRT497330 | IRF4 | interferon regulatory factor 4 | |
|
2 | 2 | ||||||
| MIRT498272 | KIAA1644 | KIAA1644 | |
|
2 | 2 | ||||||
| MIRT498634 | CHD4 | chromodomain helicase DNA binding protein 4 | |
|
2 | 10 | ||||||
| MIRT500581 | USP53 | ubiquitin specific peptidase 53 | |
|
2 | 2 | ||||||
| MIRT500751 | TMPPE | transmembrane protein with metallophosphoesterase domain | |
|
2 | 6 | ||||||
| MIRT509668 | ZNF354B | zinc finger protein 354B | |
|
2 | 10 | ||||||
| MIRT510919 | PSMA2 | proteasome subunit alpha 2 | |
|
2 | 4 | ||||||
| MIRT519118 | CEP76 | centrosomal protein 76 | |
|
2 | 2 | ||||||
| MIRT526193 | ABCG2 | ATP binding cassette subfamily G member 2 (Junior blood group) | |
|
2 | 2 | ||||||
| MIRT526746 | HLA-DOB | major histocompatibility complex, class II, DO beta | |
|
2 | 2 | ||||||
| MIRT527270 | FBLN2 | fibulin 2 | |
|
2 | 2 | ||||||
| MIRT528198 | PLEKHM2 | pleckstrin homology and RUN domain containing M2 | |
|
2 | 2 | ||||||
| MIRT528330 | TBC1D22B | TBC1 domain family member 22B | |
|
2 | 2 | ||||||
| MIRT530346 | GABRB3 | gamma-aminobutyric acid type A receptor beta3 subunit | |
|
2 | 2 | ||||||
| MIRT533627 | TMX3 | thioredoxin related transmembrane protein 3 | |
|
2 | 2 | ||||||
| MIRT533738 | TMEM200C | transmembrane protein 200C | |
|
2 | 2 | ||||||
| MIRT533779 | TMEM133 | transmembrane protein 133 | |
|
2 | 2 | ||||||
| MIRT534317 | SKIDA1 | SKI/DACH domain containing 1 | |
|
2 | 2 | ||||||
| MIRT538438 | COG5 | component of oligomeric golgi complex 5 | |
|
2 | 2 | ||||||
| MIRT539156 | AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | |
|
2 | 2 | ||||||
| MIRT539474 | ADARB2 | adenosine deaminase, RNA specific B2 (inactive) | |
|
2 | 2 | ||||||
| MIRT539620 | SHISA9 | shisa family member 9 | |
|
2 | 2 | ||||||
| MIRT539650 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | |
|
2 | 2 | ||||||
| MIRT540346 | OPHN1 | oligophrenin 1 | |
|
2 | 2 | ||||||
| MIRT540412 | PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | |
|
2 | 2 | ||||||
| MIRT541200 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | |
|
2 | 2 | ||||||
| MIRT541395 | CDC27 | cell division cycle 27 | |
|
2 | 2 | ||||||
| MIRT546443 | SNX5 | sorting nexin 5 | |
|
2 | 2 | ||||||
| MIRT547369 | MSI2 | musashi RNA binding protein 2 | |
|
2 | 2 | ||||||
| MIRT553288 | TSPAN3 | tetraspanin 3 | |
|
2 | 2 | ||||||
| MIRT554402 | SERP1 | stress associated endoplasmic reticulum protein 1 | |
|
2 | 2 | ||||||
| MIRT557822 | FOXN2 | forkhead box N2 | |
|
2 | 2 | ||||||
| MIRT568530 | ANP32E | acidic nuclear phosphoprotein 32 family member E | |
|
2 | 2 | ||||||
| MIRT569508 | THYN1 | thymocyte nuclear protein 1 | |
|
2 | 2 | ||||||
| MIRT570707 | FAM69A | family with sequence similarity 69 member A | |
|
2 | 2 | ||||||
| MIRT608376 | PIWIL2 | piwi like RNA-mediated gene silencing 2 | |
|
2 | 2 | ||||||
| MIRT608483 | NKTR | natural killer cell triggering receptor | |
|
2 | 6 | ||||||
| MIRT613533 | TRA2B | transformer 2 beta homolog | |
|
2 | 2 | ||||||
| MIRT616601 | ELP2 | elongator acetyltransferase complex subunit 2 | |
|
2 | 2 | ||||||
| MIRT618166 | DUSP18 | dual specificity phosphatase 18 | |
|
2 | 2 | ||||||
| MIRT632059 | CEP135 | centrosomal protein 135 | |
|
2 | 2 | ||||||
| MIRT647379 | ZDHHC23 | zinc finger DHHC-type containing 23 | |
|
2 | 2 | ||||||
| MIRT648366 | POTED | POTE ankyrin domain family member D | |
|
2 | 2 | ||||||
| MIRT651075 | ZNF518B | zinc finger protein 518B | |
|
2 | 4 | ||||||
| MIRT653618 | SLC30A4 | solute carrier family 30 member 4 | |
|
2 | 2 | ||||||
| MIRT653636 | SLC30A1 | solute carrier family 30 member 1 | |
|
2 | 2 | ||||||
| MIRT654895 | POU2F1 | POU class 2 homeobox 1 | |
|
2 | 2 | ||||||
| MIRT656232 | MFSD6 | major facilitator superfamily domain containing 6 | |
|
2 | 2 | ||||||
| MIRT659880 | CAPRIN1 | cell cycle associated protein 1 | |
|
2 | 2 | ||||||
| MIRT660526 | ARL4C | ADP ribosylation factor like GTPase 4C | |
|
2 | 2 | ||||||
| MIRT666286 | SLC30A3 | solute carrier family 30 member 3 | |
|
2 | 2 | ||||||
| MIRT686808 | SNX2 | sorting nexin 2 | |
|
2 | 4 | ||||||
| MIRT695302 | TK1 | thymidine kinase 1 | |
|
2 | 2 | ||||||
| MIRT699737 | SERINC3 | serine incorporator 3 | |
|
2 | 2 | ||||||
| MIRT700794 | PIAS2 | protein inhibitor of activated STAT 2 | |
|
2 | 2 | ||||||
| MIRT712270 | PPP1CB | protein phosphatase 1 catalytic subunit beta | |
|
2 | 2 | ||||||
| MIRT712617 | KNSTRN | kinetochore localized astrin/SPAG5 binding protein | |
|
2 | 2 | ||||||
| MIRT714264 | RPL10A | ribosomal protein L10a | |
|
2 | 2 | ||||||
| MIRT715072 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | |
|
2 | 2 | ||||||
| MIRT715386 | TADA3 | transcriptional adaptor 3 | |
|
2 | 2 | ||||||
| MIRT716397 | NPAS1 | neuronal PAS domain protein 1 | |
|
2 | 2 | ||||||
| MIRT725328 | NFASC | neurofascin | |
|
2 | 2 | ||||||
| MIRT725503 | GANAB | glucosidase II alpha subunit | |
|
2 | 2 | ||||||
| MIRT732913 | IRAK2 | interleukin 1 receptor associated kinase 2 | |
|
|
3 | 0 | |||||
| MIRT734890 | SMAD3 | SMAD family member 3 | |
|
|
3 | 0 | |||||
| MIRT737328 | LINC02476 | long intergenic non-protein coding RNA 2476 | |
|
|
3 | 0 | |||||
| MIRT737544 | MALAT1 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | |
|
|
|
4 | 0 | ||||
| MIRT755545 | PAK1 | p21 (RAC1) activated kinase 1 | 3 | 1 | ||||||||
| miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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