miRTarBase - #MIRT486980


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pre-miRNA Information
pre-miRNA hsa-mir-4283-1   
Genomic Coordinates chr7: 56955785 - 56955864
Description Homo sapiens miR-4283-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4283-2   
Genomic Coordinates chr7: 63621090 - 63621169
Description Homo sapiens miR-4283-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4283
Sequence 11| UGGGGCUCAGCGAGUUU |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1465673533 6 dbSNP
rs1170916691 8 dbSNP
rs1318965636 9 dbSNP
rs1372440894 11 dbSNP
rs1268430213 11 dbSNP
rs1430450794 12 dbSNP
rs1480893789 12 dbSNP
rs1304625952 13 dbSNP
rs1451132774 17 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol STEAP3   
Synonyms AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde
Description STEAP3 metalloreductase
Transcript NM_001008410   
Other Transcripts NM_018234 , NM_182915   
Expression
Putative miRNA Targets on STEAP3
3'UTR of STEAP3
(miRNA target sites are highlighted)		 
>STEAP3|NM_001008410|3'UTR
   1 GGTGCCTGCCCTGGGCTCTGGACCCCGGGCACACGAGGGACGGTGCCCTGAGCCCGTTAGGTTTTCTTTTCTTGGTGGTG
  81 CAAAGTGGTATAACTGTGTGCAAATAGGAGGTTTGAGGTCCAAATTCCTGGGACTCAAATGTATGCAGTACTATTCAGAA
 161 TGATATACACACATATGTGTATATGTATTTACATATATTCCACATATATAACAGGATTTGCAATTATACATAGCTAGCTA
 241 AAAAGTTGGGTCTCTGAGATTTCAACTTGTAGATTTAAAAACAAGTGCCGTACGTTAAGAGAAGAGCAGATCATGCTATT
 321 GTGACATTTGCAGAGATATACACACACTTTTTGTACAGAAGAGGCTTGTGCTGTGGTGGGTTCGATTTATCCCTGCCCAC
 401 CCCACCCCCACAACTTCCCTTTTGCTACTTCCCCAAGGCTCTTGCAGAGCTAGGGCTCTGAAGGGGAGGGAAGGCAACGG
 481 CTCTGCCCAGAGCCATCCCTGGAGCATGTGAGCAGCGGCTGGTCTCTTCCCTCCACCTGGGGCAGCAGCAGGAGGCCTGG
 561 GGAGGAGGAAAATCAGGCAGTCGGCCTGGAGTCTGTGCCTGGTCCTTTGCCCGGTGGTGGGAGGATGGAGGGATTGGGCT
 641 GAAGCTGCTCCACCTCATCCTTGCTGAGTGGGGGAGACATTTTCCCTGAAAGTCAGAAGTCACCATAGAGCCTGCAAATG
 721 GATCCTCCTGTGAGAGTGACGTCACCTCCTTTCCAGAGCCATTAGTGAGCCTGGCTTGGGAACAAGTGTAATTTCCTTCC
 801 CTCCTTTAACCTGGCGATGAGCGTCCTTTAAACCACTGTGCCTTCTCACCCTTTCCATCTTCAGTTTGAATGACTCCCAG
 881 GAAGGCCTAGAGCAGACCCTTTAGAAATCAGCCCAAGGGGGAGAGCAAGAGAAAACACTCTAGGGAGTAAAGCTCCCCGG
 961 GCGTCAGAGTTGAGCCCTGCCTGGGCTGAAGGACTGTCTTCACGAAGTCAGTCCTGAGGAAAAATATTGGGGACTCCAAA
1041 TGTCCTCTGGCAGAGGACCCAGAAAACCACACTGGCTCCAACTTCCTCCTCATGGGGCATTACACTTCAAAACAGTGGGG
1121 AGCAACTTTTCCACCAAAGCTACAAACCTAAAATGCTGCTGCCCCAAAGCACAAGAGGGAAGAGCACCGCCGGGGCCACA
1201 GGACGTCTGTCCTCCAGTCACAGGCCATCCTTGCTGCTCCCTACTGACTCTAGCTTACTTCCCCTGTGAAGAAACAGGTG
1281 TTCTCGGCTGAGCCCCCAACCCTCTGCAGAACCAGGTTGATCTGCCACAGAAAAAGCATCTTTGAAGACAAAGAGGGTGA
1361 GGTCTTCATGAGTCTCCTGGGCCCAAAGCCATCTTCTGATGGAAGGAAGAGAGTAGGGCCAGTGAAGGCTGCCCAGAGAG
1441 AATGTCACAGATGAGGCTGCCCCTGCCCCCCCCCCGCCAGGGAGGTTTCATGAGCTCATGTCTATGCAGCACATAAGGGT
1521 TCTTCAGTGAAAAGCAGGAGAAGAGCCCACTGCAAGGATAGCTCATTAGGCACATGACCGATGCAGGGAAGGCCATGCCG
1601 GGGAAGCTCTTCCTGCAGGTATTTTCCATCTGCTGTGCCAAGGCTGAGCGGCAGAAACTTGTCTCATAAATTGGCACTGA
1681 TGGAGCATCAGCTGTGGCCCACAGAGAGCCTTGCTGAGAAGGGGGCAGGTAAAGCAGAGATTTTAGCATTGCCTTGGCAT
1761 AACAAGGGCCCATCGATTCCCTACTAATGAGAGGCAGGGAGAGCATGGGCAATGGAGACCCACCAATGATCCCCAACCCC
1841 GGTGGGTACTGGCTGCCTGCCCTGGGCCAGGGAATGGCTCCTTATACCAAAGATGCTGGCACATAGCAGAACCCAGTGCA
1921 CGTCCTCCCCTTCCCACCCACCTCTGGCTGAAGGTGCTCAAGAGGGAAGCAATTATAAGGTGGGTGGCAGGAGGGAACAG
2001 GTGCCACCTGCTGGACAATCACACGAAAGGCAGGCGGGCTGTGTACTGGGCCCTGACTGTGCGTCCACTGCTGTCTTCCC
2081 TACCTCACCAGGCTACTGGCAGCAGCATCCCGAGAGCACATCATCTCCACAGCCTGGTAAATTCCATGTGCCTCTGGGTA
2161 CAAAAGTGCCTCAACGACATGCTCTGGAAATCCCAAATGCCACAGTCTGAGGTTGATATCTAAAATCTATGCCTTCAAAA
2241 GAGTCTCTGTTTTTTTTTTTTAACCTGGTAGACAGTATAAAAGCAGTGCAAATAAACACCTAACCTTCTGCAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuGAG-CGACUCGGGGu 5'
             ||| |||||||||| 
Target 5' gttCTCGGCTGAGCCCCc 3'
 1280 - 1297 162.00 -23.70
2 
miRNA  3' uuugagCGACUCGGGGu 5'
                |:|||||||: 
Target 5' gtcagaGTTGAGCCCTg 3'
 963 - 979 135.00 -15.20
3 
miRNA  3' uuugaGCGACUCGGGgu 5'
               | ||||||||  
Target 5' cggtgCCCTGAGCCCgt 3'
 41 - 57 132.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN213464 25 COSMIC
COSN30101501 28 COSMIC
COSN2558002 36 COSMIC
COSN30556180 46 COSMIC
COSN31523394 94 COSMIC
COSN1782011 205 COSMIC
COSN18716924 242 COSMIC
COSN30174190 695 COSMIC
COSN31593840 712 COSMIC
COSN9856842 782 COSMIC
COSN30543750 950 COSMIC
COSN18850510 1121 COSMIC
COSN23709634 1171 COSMIC
COSN9075730 1197 COSMIC
COSN28201336 1363 COSMIC
COSN17037885 1446 COSMIC
COSN23832059 1468 COSMIC
COSN32062985 1469 COSMIC
COSN27535229 1476 COSMIC
COSN20097086 1477 COSMIC
COSN22899042 1479 COSMIC
COSN28201743 1565 COSMIC
COSN8756353 1599 COSMIC
COSN20928466 1860 COSMIC
COSN6204705 1875 COSMIC
COSN9227617 1909 COSMIC
COSN17078593 2026 COSMIC
COSN29045445 2262 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs767974551 4 dbSNP
rs1308053119 6 dbSNP
rs957778416 8 dbSNP
rs1189068757 10 dbSNP
rs1386387860 11 dbSNP
rs1326252938 14 dbSNP
rs1444627902 15 dbSNP
rs1162053847 24 dbSNP
rs753232184 27 dbSNP
rs766265633 27 dbSNP
rs147303947 28 dbSNP
rs963767138 31 dbSNP
rs201407133 35 dbSNP
rs758064666 36 dbSNP
rs923536484 38 dbSNP
rs1383125255 40 dbSNP
rs779621353 42 dbSNP
rs370568683 43 dbSNP
rs544816246 44 dbSNP
rs1245152883 45 dbSNP
rs1312570278 47 dbSNP
rs999476826 54 dbSNP
rs771138329 56 dbSNP
rs556534362 57 dbSNP
rs1198589040 69 dbSNP
rs749324872 69 dbSNP
rs574854030 71 dbSNP
rs774627341 72 dbSNP
rs1256644298 73 dbSNP
rs1461206797 73 dbSNP
rs1182304707 76 dbSNP
rs933604351 80 dbSNP
rs1456117693 81 dbSNP
rs983616892 82 dbSNP
rs1197009993 84 dbSNP
rs759874514 89 dbSNP
rs1420015630 93 dbSNP
rs767900764 95 dbSNP
rs974618962 97 dbSNP
rs1196247063 99 dbSNP
rs140893688 101 dbSNP
rs1254789476 103 dbSNP
rs1233090786 104 dbSNP
rs1337391593 106 dbSNP
rs1405452411 109 dbSNP
rs761197484 119 dbSNP
rs952169593 120 dbSNP
rs942059746 121 dbSNP
rs1037804368 132 dbSNP
rs940941705 135 dbSNP
rs981690080 142 dbSNP
rs764533469 144 dbSNP
rs749946649 146 dbSNP
rs368056104 150 dbSNP
rs1366800047 164 dbSNP
rs1454245915 165 dbSNP
rs1365384912 166 dbSNP
rs34749981 167 dbSNP
rs937482150 178 dbSNP
rs1299692508 180 dbSNP
rs895113369 182 dbSNP
rs916283091 185 dbSNP
rs948060137 192 dbSNP
rs1254162454 194 dbSNP
rs946526111 201 dbSNP
rs1486466751 202 dbSNP
rs1288651498 203 dbSNP
rs1046860365 209 dbSNP
rs1214943028 215 dbSNP
rs561219293 224 dbSNP
rs906442169 231 dbSNP
rs1315324653 241 dbSNP
rs999435050 245 dbSNP
rs190673111 246 dbSNP
rs1311376879 251 dbSNP
rs1382762093 259 dbSNP
rs759873019 271 dbSNP
rs1010582420 272 dbSNP
rs1293836835 286 dbSNP
rs1490505501 287 dbSNP
rs1040289729 289 dbSNP
rs866784432 290 dbSNP
rs142474087 291 dbSNP
rs1186891756 294 dbSNP
rs767963979 295 dbSNP
rs1265999166 297 dbSNP
rs74947577 299 dbSNP
rs1182718917 307 dbSNP
rs532638094 317 dbSNP
rs1363509349 319 dbSNP
rs1028827530 326 dbSNP
rs1292950108 328 dbSNP
rs775818310 329 dbSNP
rs372144765 345 dbSNP
rs1006297467 348 dbSNP
rs1014868334 354 dbSNP
rs1165602532 357 dbSNP
rs1341783955 358 dbSNP
rs1276244328 365 dbSNP
rs925091248 369 dbSNP
rs79930868 380 dbSNP
rs983712157 381 dbSNP
rs937838133 382 dbSNP
rs1325253236 384 dbSNP
rs908014176 390 dbSNP
rs942195023 396 dbSNP
rs1388883374 397 dbSNP
rs928852198 401 dbSNP
rs1425780387 403 dbSNP
rs3769653 406 dbSNP
rs916655892 408 dbSNP
rs1477774989 410 dbSNP
rs992029387 416 dbSNP
rs1201425272 421 dbSNP
rs10171408 426 dbSNP
rs1450199028 432 dbSNP
rs530080535 436 dbSNP
rs948169733 439 dbSNP
rs1046388494 442 dbSNP
rs1399007440 444 dbSNP
rs1195961755 449 dbSNP
rs927955536 450 dbSNP
rs1319396486 451 dbSNP
rs1255604805 456 dbSNP
rs1217986351 460 dbSNP
rs1392334467 464 dbSNP
rs1276501470 465 dbSNP
rs1329110182 466 dbSNP
rs1330235479 468 dbSNP
rs1375764192 470 dbSNP
rs1237290216 475 dbSNP
rs1447786009 475 dbSNP
rs1402617663 479 dbSNP
rs914779359 480 dbSNP
rs946435076 481 dbSNP
rs1465600239 482 dbSNP
rs1174779209 484 dbSNP
rs1316490174 495 dbSNP
rs1359565578 502 dbSNP
rs1377361181 503 dbSNP
rs1245089323 504 dbSNP
rs1458797958 505 dbSNP
rs548621796 517 dbSNP
rs935213384 518 dbSNP
rs1197493008 522 dbSNP
rs1365502788 524 dbSNP
rs923703734 540 dbSNP
rs1280661435 541 dbSNP
rs1052314911 546 dbSNP
rs1196219389 550 dbSNP
rs1279905644 552 dbSNP
rs893749971 555 dbSNP
rs1379361373 565 dbSNP
rs1329518883 566 dbSNP
rs1446164355 567 dbSNP
rs113397926 569 dbSNP
rs1336723929 571 dbSNP
rs1039979088 578 dbSNP
rs1243771444 581 dbSNP
rs534645752 584 dbSNP
rs1159594777 587 dbSNP
rs1050680002 588 dbSNP
rs998345926 590 dbSNP
rs553122530 592 dbSNP
rs1177558209 603 dbSNP
rs1375351889 611 dbSNP
rs887649050 613 dbSNP
rs577153252 614 dbSNP
rs1284745458 615 dbSNP
rs1398601353 624 dbSNP
rs1444061373 629 dbSNP
rs7590206 637 dbSNP
rs1351176353 640 dbSNP
rs1307366415 661 dbSNP
rs1338314769 665 dbSNP
rs1380066175 666 dbSNP
rs1286018327 669 dbSNP
rs73948634 671 dbSNP
rs1005115438 679 dbSNP
rs1432435282 690 dbSNP
rs538837250 696 dbSNP
rs556606311 697 dbSNP
rs1035698094 702 dbSNP
rs1157742035 704 dbSNP
rs1405576585 707 dbSNP
rs562670596 715 dbSNP
rs1415389453 720 dbSNP
rs1179578956 722 dbSNP
rs1472156989 724 dbSNP
rs1242659529 735 dbSNP
rs1195687954 741 dbSNP
rs149904538 742 dbSNP
rs1285040362 747 dbSNP
rs963651998 750 dbSNP
rs1322533933 760 dbSNP
rs144970070 780 dbSNP
rs1309239926 783 dbSNP
rs1292241109 788 dbSNP
rs532510686 802 dbSNP
rs968850624 816 dbSNP
rs916773923 817 dbSNP
rs1402388283 823 dbSNP
rs140786063 824 dbSNP
rs923649479 834 dbSNP
rs1436799488 835 dbSNP
rs1243976601 838 dbSNP
rs1460922056 839 dbSNP
rs982610652 842 dbSNP
rs758230485 846 dbSNP
rs79618893 867 dbSNP
rs7581339 872 dbSNP
rs565577844 875 dbSNP
rs922997799 878 dbSNP
rs1191587639 888 dbSNP
rs181756117 894 dbSNP
rs1248684010 912 dbSNP
rs1219563908 919 dbSNP
rs946676920 920 dbSNP
rs1421866644 922 dbSNP
rs1471165712 930 dbSNP
rs373092121 939 dbSNP
rs1278080075 941 dbSNP
rs1387733629 944 dbSNP
rs562939158 948 dbSNP
rs1465090065 949 dbSNP
rs997917782 950 dbSNP
rs1332769525 954 dbSNP
rs1051309804 957 dbSNP
rs886882442 959 dbSNP
rs1036161845 960 dbSNP
rs1003867661 963 dbSNP
rs144620101 964 dbSNP
rs1434688480 970 dbSNP
rs1277503694 973 dbSNP
rs111802909 977 dbSNP
rs995497832 991 dbSNP
rs566912127 997 dbSNP
rs1225182354 998 dbSNP
rs1263971914 1003 dbSNP
rs3731603 1004 dbSNP
rs894499079 1014 dbSNP
rs969973045 1018 dbSNP
rs1208068631 1019 dbSNP
rs1262521525 1027 dbSNP
rs546530318 1028 dbSNP
rs1456464064 1035 dbSNP
rs58353998 1071 dbSNP
rs1234522450 1076 dbSNP
rs1314377837 1082 dbSNP
rs1299633716 1084 dbSNP
rs538429675 1099 dbSNP
rs1218332416 1101 dbSNP
rs1261746011 1102 dbSNP
rs956821320 1106 dbSNP
rs556766134 1113 dbSNP
rs568597592 1121 dbSNP
rs977546244 1124 dbSNP
rs1303420831 1125 dbSNP
rs74816667 1149 dbSNP
rs975750682 1153 dbSNP
rs774526909 1162 dbSNP
rs1031881773 1163 dbSNP
rs956437159 1167 dbSNP
rs796348721 1189 dbSNP
rs933802539 1190 dbSNP
rs554143312 1192 dbSNP
rs886848134 1193 dbSNP
rs1283729312 1204 dbSNP
rs572703968 1204 dbSNP
rs1484514789 1205 dbSNP
rs138743483 1206 dbSNP
rs1038000038 1209 dbSNP
rs1217633063 1210 dbSNP
rs772275122 1211 dbSNP
rs1309432633 1216 dbSNP
rs775936307 1230 dbSNP
rs1312779213 1232 dbSNP
rs761020466 1244 dbSNP
rs995070165 1245 dbSNP
rs941955841 1251 dbSNP
rs191327690 1255 dbSNP
rs555939106 1257 dbSNP
rs1024324725 1267 dbSNP
rs905466027 1280 dbSNP
rs1160748979 1281 dbSNP
rs1418084680 1286 dbSNP
rs1363352563 1287 dbSNP
rs764655120 1288 dbSNP
rs897691534 1290 dbSNP
rs1035191946 1291 dbSNP
rs1187769841 1293 dbSNP
rs938745927 1295 dbSNP
rs1214060916 1298 dbSNP
rs1349464831 1300 dbSNP
rs183139903 1302 dbSNP
rs1319344667 1319 dbSNP
rs187677186 1320 dbSNP
rs1400531176 1324 dbSNP
rs1012883306 1330 dbSNP
rs1296097944 1331 dbSNP
rs544795795 1334 dbSNP
rs1021636506 1336 dbSNP
rs1384567541 1337 dbSNP
rs1022226136 1344 dbSNP
rs1164004023 1346 dbSNP
rs1459511414 1352 dbSNP
rs1366790238 1354 dbSNP
rs563107125 1365 dbSNP
rs1164898440 1382 dbSNP
rs574977078 1394 dbSNP
rs975464007 1399 dbSNP
rs921169285 1416 dbSNP
rs1157578313 1422 dbSNP
rs1265844369 1429 dbSNP
rs1378368834 1447 dbSNP
rs1446734317 1452 dbSNP
rs1426425933 1454 dbSNP
rs1271976182 1466 dbSNP
rs1313368447 1466 dbSNP
rs138092238 1466 dbSNP
rs376661204 1466 dbSNP
rs1319879371 1468 dbSNP
rs201556049 1468 dbSNP
rs6753005 1469 dbSNP
rs767279407 1470 dbSNP
rs1466170705 1471 dbSNP
rs977344985 1471 dbSNP
rs370326945 1472 dbSNP
rs6753006 1472 dbSNP
rs1198765898 1473 dbSNP
rs76738995 1473 dbSNP
rs12476967 1474 dbSNP
rs1345519140 1474 dbSNP
rs199868725 1474 dbSNP
rs146004421 1475 dbSNP
rs532733118 1475 dbSNP
rs754322658 1475 dbSNP
rs985775283 1475 dbSNP
rs10571222 1476 dbSNP
rs908923026 1476 dbSNP
rs1198538837 1477 dbSNP
rs1491297426 1477 dbSNP
rs376151247 1477 dbSNP
rs75621189 1477 dbSNP
rs971977573 1478 dbSNP
rs919193297 1479 dbSNP
rs939717912 1483 dbSNP
rs1038138901 1501 dbSNP
rs1374400830 1503 dbSNP
rs1239481787 1504 dbSNP
rs201034319 1505 dbSNP
rs1442171468 1516 dbSNP
rs1361705367 1517 dbSNP
rs898139777 1519 dbSNP
rs1433265505 1520 dbSNP
rs1289795118 1522 dbSNP
rs1158933167 1523 dbSNP
rs1421115198 1536 dbSNP
rs779161385 1536 dbSNP
rs1176152659 1537 dbSNP
rs1472812318 1538 dbSNP
rs1239147504 1546 dbSNP
rs1185240186 1548 dbSNP
rs948370204 1551 dbSNP
rs915955647 1560 dbSNP
rs140421299 1562 dbSNP
rs1207134934 1573 dbSNP
rs1282377490 1574 dbSNP
rs1223317767 1578 dbSNP
rs1357077195 1580 dbSNP
rs143529095 1581 dbSNP
rs1457964719 1583 dbSNP
rs1413471758 1584 dbSNP
rs1043069726 1600 dbSNP
rs1235769558 1601 dbSNP
rs905442080 1613 dbSNP
rs904554348 1617 dbSNP
rs1343094564 1621 dbSNP
rs1157841950 1626 dbSNP
rs1003802483 1627 dbSNP
rs534138154 1629 dbSNP
rs1405447409 1633 dbSNP
rs1035116982 1634 dbSNP
rs764877475 1638 dbSNP
rs892651098 1640 dbSNP
rs1474828128 1647 dbSNP
rs1424122714 1650 dbSNP
rs1009585202 1651 dbSNP
rs755299515 1662 dbSNP
rs1240597116 1663 dbSNP
rs968190347 1664 dbSNP
rs1215253622 1681 dbSNP
rs1452327790 1682 dbSNP
rs1292082775 1686 dbSNP
rs577674299 1694 dbSNP
rs781561991 1698 dbSNP
rs999091529 1698 dbSNP
rs750050089 1701 dbSNP
rs10204553 1710 dbSNP
rs901437356 1724 dbSNP
rs955426638 1726 dbSNP
rs1287990726 1734 dbSNP
rs986721410 1745 dbSNP
rs1446262043 1754 dbSNP
rs1323276293 1769 dbSNP
rs908346878 1769 dbSNP
rs961217307 1775 dbSNP
rs373189675 1776 dbSNP
rs998330363 1778 dbSNP
rs1384995669 1782 dbSNP
rs1172664774 1783 dbSNP
rs1426528084 1792 dbSNP
rs973924864 1795 dbSNP
rs1186210780 1807 dbSNP
rs919662120 1809 dbSNP
rs953154523 1810 dbSNP
rs948538481 1813 dbSNP
rs1015863202 1819 dbSNP
rs1468043841 1821 dbSNP
rs962990676 1822 dbSNP
rs971717263 1831 dbSNP
rs1306179548 1832 dbSNP
rs1295279061 1834 dbSNP
rs532307665 1841 dbSNP
rs202208885 1842 dbSNP
rs1300745569 1843 dbSNP
rs1216659177 1844 dbSNP
rs1439544338 1864 dbSNP
rs939570623 1865 dbSNP
rs1056663362 1878 dbSNP
rs1274101295 1895 dbSNP
rs568761735 1900 dbSNP
rs536042681 1906 dbSNP
rs538392628 1909 dbSNP
rs1009679940 1910 dbSNP
rs1043907889 1918 dbSNP
rs1353745614 1919 dbSNP
rs903932474 1922 dbSNP
rs948817159 1923 dbSNP
rs1397130042 1924 dbSNP
rs1191908588 1925 dbSNP
rs1453930394 1945 dbSNP
rs1238850985 1955 dbSNP
rs1179512946 1958 dbSNP
rs1479926642 1960 dbSNP
rs1251204926 1976 dbSNP
rs141758509 1977 dbSNP
rs566576109 1992 dbSNP
rs934622234 1995 dbSNP
rs569419558 2002 dbSNP
rs766025053 2025 dbSNP
rs1310788143 2026 dbSNP
rs751369661 2027 dbSNP
rs1008123861 2032 dbSNP
rs1236803703 2037 dbSNP
rs1471748964 2053 dbSNP
rs1188234702 2054 dbSNP
rs1423996049 2058 dbSNP
rs1373387743 2062 dbSNP
rs533525177 2063 dbSNP
rs3731602 2064 dbSNP
rs1161414816 2068 dbSNP
rs1417348791 2104 dbSNP
rs781087832 2112 dbSNP
rs1182887425 2115 dbSNP
rs577449043 2118 dbSNP
rs1470331880 2138 dbSNP
rs1049916772 2141 dbSNP
rs919773573 2145 dbSNP
rs1354006259 2148 dbSNP
rs1333638292 2149 dbSNP
rs889981643 2152 dbSNP
rs1236267200 2160 dbSNP
rs1315737074 2161 dbSNP
rs374480201 2162 dbSNP
rs1397699316 2163 dbSNP
rs538579406 2166 dbSNP
rs1312013061 2168 dbSNP
rs752672470 2176 dbSNP
rs979889850 2177 dbSNP
rs1015937222 2187 dbSNP
rs554014522 2190 dbSNP
rs938333615 2192 dbSNP
rs1451729461 2193 dbSNP
rs1275887779 2195 dbSNP
rs1052750096 2198 dbSNP
rs558325300 2210 dbSNP
rs963105897 2213 dbSNP
rs1166186746 2215 dbSNP
rs575038479 2216 dbSNP
rs542450548 2220 dbSNP
rs1416200878 2229 dbSNP
rs945669145 2231 dbSNP
rs1488786554 2235 dbSNP
rs1263412552 2240 dbSNP
rs1202996986 2244 dbSNP
rs1485291633 2248 dbSNP
rs75430662 2248 dbSNP
rs780345116 2248 dbSNP
rs1461706067 2250 dbSNP
rs200701415 2250 dbSNP
rs57325038 2250 dbSNP
rs904026375 2252 dbSNP
rs959974561 2252 dbSNP
rs1380733761 2269 dbSNP
rs572532448 2274 dbSNP
rs4849771 2275 dbSNP
rs1164749467 2279 dbSNP
rs891228968 2289 dbSNP
rs1191291822 2294 dbSNP
rs1008218498 2300 dbSNP
rs79189358 2301 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuGAG-CGACUCGGGGu 5'
             ||| |||||||||| 
Target 5' --uCUCGGCUGAGCCCCc 3'
 		1 - 16
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuGAG-CGACUCGGGGu 5'
             ||| |||||||||| 
Target 5' --uCUCGGCUGAGCCCCc 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000409811.1 | 3UTR | UCUCGGCUGAGCCCCCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000409811.1 | 3UTR | UCUCGGCUGAGCCCCCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-4283 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT083347 E2F1 E2F transcription factor 1 2 4
MIRT120466 U2SURP U2 snRNP associated SURP domain containing 2 4
MIRT266892 HDGF heparin binding growth factor 2 2
MIRT445166 TFPI tissue factor pathway inhibitor 2 2
MIRT445906 SLC10A3 solute carrier family 10 member 3 2 2
MIRT455530 GJB1 gap junction protein beta 1 2 2
MIRT460172 UNK unkempt family zinc finger 2 6
MIRT461728 SLC27A1 solute carrier family 27 member 1 2 2
MIRT465219 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT468911 RPS6KA4 ribosomal protein S6 kinase A4 2 2
MIRT469691 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT471050 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT472526 NACC1 nucleus accumbens associated 1 2 2
MIRT474932 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT486980 STEAP3 STEAP3 metalloreductase 2 4
MIRT487483 BANP BTG3 associated nuclear protein 2 4
MIRT488263 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT490733 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT490896 BARHL1 BarH like homeobox 1 2 6
MIRT490909 STRN4 striatin 4 2 2
MIRT493812 FSCN1 fascin actin-bundling protein 1 2 2
MIRT509030 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 2
MIRT509049 AKAP2 A-kinase anchoring protein 2 2 2
MIRT509404 MCM7 minichromosome maintenance complex component 7 2 6
MIRT523303 HIST1H1B histone cluster 1 H1 family member b 2 2
MIRT529487 TPD52L3 tumor protein D52 like 3 2 2
MIRT529825 ARGFX arginine-fifty homeobox 2 4
MIRT542941 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT543668 PUM1 pumilio RNA binding family member 1 2 4
MIRT546994 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT560377 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT561752 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT568966 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569892 ROBO4 roundabout guidance receptor 4 2 2
MIRT570097 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT576503 Slc35e2 solute carrier family 35, member E2 2 3
MIRT623795 GK5 glycerol kinase 5 (putative) 2 2
MIRT625142 ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 2 2
MIRT631438 HSPA14 heat shock protein family A (Hsp70) member 14 2 2
MIRT633973 SLC35E2 solute carrier family 35 member E2 2 3
MIRT634811 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT640520 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT644446 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644767 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT648809 ZNF689 zinc finger protein 689 2 2
MIRT654912 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2 2
MIRT670832 SFT2D2 SFT2 domain containing 2 2 2
MIRT675826 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT684020 FOLR1 folate receptor 1 2 2
MIRT698589 TEX261 testis expressed 261 2 2
MIRT703208 GOLGA3 golgin A3 2 2
MIRT703492 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT710754 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4283 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4283 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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