miRTarBase - #MIRT487814


—
pre-miRNA Information
pre-miRNA hsa-mir-4731   
Genomic Coordinates chr17: 15251627 - 15251696
Description Homo sapiens miR-4731 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4731-5p
Sequence 10| UGCUGGGGGCCACAUGAGUGUG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1295173963 9 dbSNP
rs1227560397 15 dbSNP
rs972231157 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PER3   
Synonyms FASPS3, GIG13
Description period circadian clock 3
Transcript NM_016831   
Expression
Putative miRNA Targets on PER3
3'UTR of PER3
(miRNA target sites are highlighted)		 
>PER3|NM_016831|3'UTR
   1 GTGACTGTGAGGATGAACCTTCATACCCTTTCCAAGACGTGTTACACAGACAGACCTTTTTAAGTCCTGGACTTTTAAAT
  81 GACCATGAAGTTATCATTGAATGTTAAGATTTTTTCTTCTTGATTTTTTAATACACGTAATCTTTTTGAAGCAGACATTG
 161 TATACAGAATCTTACTTCTCTTTGTTCCTGATATATTAAAATGGCCAGTTAGGCTCTTTTTGTAGTTGAATTGTCTTCTA
 241 AAGAGATTGGATGGCCTCTAAAGAGGTATGTGTATCTTTATTTCAGATGTCACCCAGAGTAAATTATAATTAGAAGTATA
 321 GCTAGAATGAGCCCCAAACCTTAGCCTCATTTATTTTGTTCTGTTACATAAGTCATTTTCCCCTTAGAGTGCTTGAAGAA
 401 ATGCCACCTACAGGTTGTGTACTTTTCATAATGGTTTCCATGAATGTAGTACGTTCATACAGGCTTCATTCAACCTGGCG
 481 TTCCCCTCCATAATTAAGATGAAACATTCCGGTTTTCTCACAACACATTAGCACATACTGTCCATTAGCATATCTGGGAT
 561 AACCAGGTTTTGGGGGTTGAGTTTTGGCCTTCATCCTTGTAGATCCCTTTCCTATTGATTTCCCACCTTCCAGTGAAATT
 641 CTGAAAGTCTTATCTTAAAAATCGATCCGCTTACCATGGGCCTATTCTTGTAAGTTTCAGTTAGCATTTGCATGTGTAAT
 721 ATTAAAATGAAAGAGCTTCTTACCCAGTGCTGTTGCCCTTTTGAGTATTTTTGTTTTTAAAATAATGATTGTAAAATGTT
 801 TTACAAGTAATGTAAAAGCTAGTATCATTCTTACATACTTCTGTGTTTAAATTTTCATTCTTACCAAAACAGTTAACTCT
 881 TTCTTTCCAATCAATTTATACAAAAGAGGTCGCTCCAGCCCTACCACAGGTCTGACTGGCACTGCCTTTTGTTTGCCCTT
 961 GAACAGGGCAGTGTTGTGGGGACTGCAAAAGAGAAAACGTCCAGGCGAGCCCAGTTGTCCTCGCCCACAGGGTCCTGCAG
1041 GCTCCATCAGTCACCGCTTTCTATGGCGTTTGTAGTTGTGTCTTTTAAGAAGTGAGTGTGATTGTTTACTTGATAAATCA
1121 GCTCACTCTCTGGTGCTTTTTAGAGAAGTCCCTGATTCCTTCTTAAACTTGGAATGATAGATGAAATTCACACCCCTGCA
1201 GATCAGAAAAAACAAATAGAAGAAAATGAGGGTTACAGTAACCTGTTGTCTTTATATAACTTGCAACAAACTAATTTATT
1281 TTTTTTTCCTTTTTTTGTTTTTGGTTTTTTATGGTTTTTTAAGGAAAATACTTTTCTCCTTTGAAGTTTTACAGCTTTTT
1361 GTAAATGCGTCCTGATAATGATTAGGAAAATCGACCTTTTCATCCATGATGACCATCCTCATAGCTCAGATCTCCTTTCA
1441 AAGTAGTGGCTTTCTGGATGGTAATTCCATCTTAAGGTGTCAGAACTATTTTCAAATGCTGCCTTTGACAGTTCTTGGAA
1521 TTTTCTGATATTAAGCAGTTCCATGCAAATATTCGTGTTTTATAAATAGCTCTCATAGTCTGCTCCATCTTGATAGTTAA
1601 GTGATTTCTGAAGCGTTTGTGTGTGTGTTGATCAGGTTGTGTGATATTTTTGCTTGATAGAGAATCAAATTTGAAACAAT
1681 TAACCAGCCAGTAGATTGTCTGTCAGTGACCTTCTGTAGTAATAAAGTTTTTGCCACTGTAAATAAAAACAGTATCCGTA
1761 GCTATCAGGATCATTGCGCACTCATATATGCTAAGCCTTCTGTTCTCTAATAGAAGCCTTTCTTTTCCATTGTTTCTGGA
1841 TATTTGTATTATCCAAATGTGCTTATTTCTTTGCCTTAGCACACGTTTTATGGAGTACTTGTTATACTAGGTTTGATTTG
1921 AAACTGGTGCTTGTCGCAGAACTGTCAGAGCATGAGGAGCGCTCCTCCTGTGGGTGGACGCATTCACGCACTCCCAGGTT
2001 GCACCTGCTGCTGGCGGTGAGCAGGGGGTTCAGCAGCTTGACCGATGCCCCCCGAGGGGGCTCTCCCCAGCTTAAACTTT
2081 GTTGTTTAAATTTGTTAACTTTTTATATTAATGACTATTGAAAGTGGTAATAAAAATTTATATTATAGGCTTCAATGTTT
2161 TCATGAATGTTACCCAAAAAGCTGTGTTTTCTTTGGTCAGAGGTCAAAATTTATGAAAAACAAAATGCTGTATGAATGGA
2241 AATCATTTTGCAATTGAGTGACACTTCATTGTAATTCACAGTGTAAATTTAATCCAAACTGAAATTTTGTTTCAACTGAA
2321 TTTGTAATTAACTCTGAATTTGTTTTTAATCATTAGTAATATTTCAGTTGGGTATCTTTTTAAGTAAAAACAACAAATAA
2401 ACTCTGTACATGTAAAACGTGAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guGUGAGUACACCG---GGGGUCGu 5'
            | |  | | |||   ||||||| 
Target 5' ccCCCCGAGGGGGCTCTCCCCAGCt 3'
 2048 - 2072 148.00 -23.90
2 
miRNA  3' guGUGAGUACACCG--GGGGUCGu 5'
            :||  | | ||:  |:||||| 
Target 5' taTACAAAAGAGGTCGCTCCAGCc 3'
 897 - 920 134.00 -13.70
3 
miRNA  3' guGUGAGUACACCGGGGGUCgu 5'
            ||:||| |   |:|||||  
Target 5' cgCATTCACG-CACTCCCAGgt 3'
 1979 - 1999 123.00 -19.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1108724 8 COSMIC
COSN19732507 11 COSMIC
COSN26506033 13 COSMIC
COSN30101784 14 COSMIC
COSN26604143 57 COSMIC
COSN30162271 123 COSMIC
COSN31599440 126 COSMIC
COSN22799891 134 COSMIC
COSN25464841 240 COSMIC
COSN31594622 295 COSMIC
COSN31579124 341 COSMIC
COSN26548621 388 COSMIC
COSN31592882 469 COSMIC
COSN31590973 480 COSMIC
COSN21315298 543 COSMIC
COSN26529321 582 COSMIC
COSN31542004 999 COSMIC
COSN30753262 1144 COSMIC
COSM7534815 1193 COSMIC
COSN21570862 1218 COSMIC
COSN30114607 1284 COSMIC
COSN30593788 1288 COSMIC
COSN31579311 1288 COSMIC
COSN30763974 1297 COSMIC
COSN7282711 1305 COSMIC
COSN31546379 1393 COSMIC
COSN31588355 1500 COSMIC
COSN8509843 1686 COSMIC
COSN31565890 1864 COSMIC
COSN5744309 2206 COSMIC
COSN9026745 2235 COSMIC
COSN1458415 2414 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200038116 4 dbSNP
rs976362208 6 dbSNP
rs1203349520 8 dbSNP
rs533400256 10 dbSNP
rs1481185722 15 dbSNP
rs1200358815 17 dbSNP
rs1254730427 19 dbSNP
rs1445854530 20 dbSNP
rs770782758 23 dbSNP
rs1389082640 24 dbSNP
rs1447281604 32 dbSNP
rs1170138731 33 dbSNP
rs775661736 34 dbSNP
rs375796183 37 dbSNP
rs1490421883 38 dbSNP
rs200568289 39 dbSNP
rs774256972 40 dbSNP
rs199713705 46 dbSNP
rs765646567 46 dbSNP
rs761958181 49 dbSNP
rs1478523341 56 dbSNP
rs1413055571 58 dbSNP
rs923589557 73 dbSNP
rs116100365 76 dbSNP
rs1441189729 77 dbSNP
rs1190587693 83 dbSNP
rs1258587345 86 dbSNP
rs986100782 95 dbSNP
rs563564725 101 dbSNP
rs1342378666 109 dbSNP
rs1400758648 110 dbSNP
rs1284108350 114 dbSNP
rs1354918663 127 dbSNP
rs1230351900 130 dbSNP
rs1157163596 137 dbSNP
rs1040619711 138 dbSNP
rs531029133 158 dbSNP
rs1215366911 171 dbSNP
rs1283443727 178 dbSNP
rs1488978156 182 dbSNP
rs1193342142 199 dbSNP
rs909307140 206 dbSNP
rs942068723 208 dbSNP
rs923557103 217 dbSNP
rs1454415422 220 dbSNP
rs1172035296 240 dbSNP
rs1418875483 241 dbSNP
rs932127968 243 dbSNP
rs1157079075 245 dbSNP
rs1362752629 248 dbSNP
rs1401332874 261 dbSNP
rs187060078 264 dbSNP
rs1333635463 269 dbSNP
rs1338803909 270 dbSNP
rs1450752997 282 dbSNP
rs1285314055 290 dbSNP
rs761630160 293 dbSNP
rs765153696 294 dbSNP
rs1401488197 296 dbSNP
rs1412798780 297 dbSNP
rs1314500805 298 dbSNP
rs61773394 300 dbSNP
rs571066741 302 dbSNP
rs1006330634 304 dbSNP
rs1036474686 315 dbSNP
rs1355460301 317 dbSNP
rs919117391 317 dbSNP
rs1408866919 332 dbSNP
rs528738345 335 dbSNP
rs1277239459 345 dbSNP
rs897815027 346 dbSNP
rs546726567 359 dbSNP
rs1318319437 368 dbSNP
rs1239222416 369 dbSNP
rs1003321338 387 dbSNP
rs1176592015 388 dbSNP
rs1034942955 390 dbSNP
rs960911285 391 dbSNP
rs1056997749 404 dbSNP
rs1012000745 406 dbSNP
rs1213562420 407 dbSNP
rs1281529511 410 dbSNP
rs894371094 411 dbSNP
rs1023437967 419 dbSNP
rs967878231 422 dbSNP
rs979137807 423 dbSNP
rs143396342 432 dbSNP
rs1400277966 439 dbSNP
rs762670221 441 dbSNP
rs535988708 446 dbSNP
rs751069132 451 dbSNP
rs1198316432 453 dbSNP
rs1378140523 454 dbSNP
rs1375937277 467 dbSNP
rs1432822374 469 dbSNP
rs1342259977 474 dbSNP
rs771763140 480 dbSNP
rs999045971 481 dbSNP
rs1196702272 485 dbSNP
rs1428918836 488 dbSNP
rs976155657 488 dbSNP
rs577506819 489 dbSNP
rs1198343662 491 dbSNP
rs957116794 492 dbSNP
rs1391549675 507 dbSNP
rs758982610 511 dbSNP
rs557469347 512 dbSNP
rs191701351 513 dbSNP
rs1030601133 516 dbSNP
rs1237171014 524 dbSNP
rs536868508 526 dbSNP
rs1397581542 527 dbSNP
rs909363432 528 dbSNP
rs558670223 540 dbSNP
rs753236300 544 dbSNP
rs577110012 545 dbSNP
rs1283319162 561 dbSNP
rs1316774115 562 dbSNP
rs1216659709 584 dbSNP
rs1253430069 588 dbSNP
rs539754548 607 dbSNP
rs909242771 615 dbSNP
rs1209079172 626 dbSNP
rs143981981 628 dbSNP
rs866677255 632 dbSNP
rs963400960 652 dbSNP
rs972586031 659 dbSNP
rs1262495620 662 dbSNP
rs919328989 664 dbSNP
rs1173455028 665 dbSNP
rs1457702858 669 dbSNP
rs938534473 669 dbSNP
rs1057443754 670 dbSNP
rs1393365422 673 dbSNP
rs1426109361 677 dbSNP
rs1455677561 684 dbSNP
rs1339192026 688 dbSNP
rs1397667177 691 dbSNP
rs538132920 703 dbSNP
rs915834038 713 dbSNP
rs896374725 714 dbSNP
rs1326997067 716 dbSNP
rs1244016274 723 dbSNP
rs1395689390 728 dbSNP
rs1448779172 737 dbSNP
rs1012100437 738 dbSNP
rs184293897 748 dbSNP
rs1355992834 749 dbSNP
rs750124019 750 dbSNP
rs967846872 751 dbSNP
rs574069699 757 dbSNP
rs1196001830 764 dbSNP
rs1263001993 768 dbSNP
rs1030709801 792 dbSNP
rs1423699421 800 dbSNP
rs1186072352 801 dbSNP
rs1462206815 802 dbSNP
rs1425692460 805 dbSNP
rs1163822829 810 dbSNP
rs1359566930 813 dbSNP
rs1417293999 815 dbSNP
rs1053297847 831 dbSNP
rs1290076564 834 dbSNP
rs541396353 835 dbSNP
rs1310492844 836 dbSNP
rs1395327124 836 dbSNP
rs1391802770 842 dbSNP
rs1384726353 843 dbSNP
rs1442511791 845 dbSNP
rs956666562 865 dbSNP
rs1308778043 866 dbSNP
rs997692231 871 dbSNP
rs1213262601 875 dbSNP
rs1482972427 890 dbSNP
rs975743198 891 dbSNP
rs1030465195 892 dbSNP
rs1178462562 895 dbSNP
rs1308402833 898 dbSNP
rs1437386506 901 dbSNP
rs1030426663 910 dbSNP
rs189418809 912 dbSNP
rs986370340 913 dbSNP
rs1363803815 928 dbSNP
rs1271551873 936 dbSNP
rs1465169788 937 dbSNP
rs1301003060 947 dbSNP
rs1469991032 956 dbSNP
rs754245290 958 dbSNP
rs1016501356 962 dbSNP
rs747218753 962 dbSNP
rs963730592 964 dbSNP
rs1225619590 969 dbSNP
rs1307978485 971 dbSNP
rs1311675100 971 dbSNP
rs1231230125 976 dbSNP
rs1247433582 976 dbSNP
rs1265517481 981 dbSNP
rs1462185753 984 dbSNP
rs909500506 993 dbSNP
rs1198596579 994 dbSNP
rs144257357 994 dbSNP
rs1236669681 998 dbSNP
rs942175265 999 dbSNP
rs148627435 1000 dbSNP
rs972064568 1007 dbSNP
rs1408341221 1011 dbSNP
rs1464389420 1020 dbSNP
rs192510953 1023 dbSNP
rs12068394 1024 dbSNP
rs1470207115 1025 dbSNP
rs1169886190 1028 dbSNP
rs11554351 1029 dbSNP
rs570036657 1030 dbSNP
rs1444196727 1040 dbSNP
rs1298944774 1042 dbSNP
rs915780231 1047 dbSNP
rs948544588 1050 dbSNP
rs938778498 1056 dbSNP
rs925869332 1057 dbSNP
rs1256788468 1059 dbSNP
rs1462676283 1061 dbSNP
rs1309622913 1063 dbSNP
rs1326009185 1064 dbSNP
rs1057109933 1068 dbSNP
rs1387230170 1069 dbSNP
rs934333669 1078 dbSNP
rs1270337830 1087 dbSNP
rs536615550 1094 dbSNP
rs1363238521 1095 dbSNP
rs894453466 1113 dbSNP
rs546085251 1114 dbSNP
rs948756064 1120 dbSNP
rs141260595 1123 dbSNP
rs1049497544 1124 dbSNP
rs1060439 1125 dbSNP
rs1293140052 1126 dbSNP
rs1170933252 1127 dbSNP
rs757501150 1130 dbSNP
rs567650539 1137 dbSNP
rs1337451798 1145 dbSNP
rs1364628760 1148 dbSNP
rs867627169 1152 dbSNP
rs866466472 1153 dbSNP
rs753152231 1156 dbSNP
rs1308411003 1164 dbSNP
rs1232997694 1165 dbSNP
rs1331669135 1173 dbSNP
rs1000619202 1178 dbSNP
rs1463041998 1182 dbSNP
rs371906128 1186 dbSNP
rs150764556 1188 dbSNP
rs779058060 1196 dbSNP
rs866318588 1197 dbSNP
rs1320303083 1201 dbSNP
rs547257750 1204 dbSNP
rs1187858467 1207 dbSNP
rs1419828063 1211 dbSNP
rs1219708967 1214 dbSNP
rs899384076 1216 dbSNP
rs548579764 1224 dbSNP
rs200580747 1225 dbSNP
rs1192360695 1232 dbSNP
rs1173706971 1233 dbSNP
rs1240250720 1234 dbSNP
rs1026356561 1237 dbSNP
rs1187060571 1249 dbSNP
rs1410746858 1253 dbSNP
rs1442619054 1254 dbSNP
rs878973433 1256 dbSNP
rs1366485926 1257 dbSNP
rs1419141367 1260 dbSNP
rs1296381319 1263 dbSNP
rs1398493325 1264 dbSNP
rs960024521 1265 dbSNP
rs992903567 1269 dbSNP
rs562095483 1277 dbSNP
rs1030112945 1278 dbSNP
rs1248697670 1278 dbSNP
rs1316690610 1279 dbSNP
rs1359759649 1279 dbSNP
rs1215481779 1283 dbSNP
rs1160650851 1288 dbSNP
rs1346368762 1289 dbSNP
rs1447869692 1290 dbSNP
rs1281461512 1298 dbSNP
rs1448228085 1298 dbSNP
rs1216402485 1302 dbSNP
rs548454890 1304 dbSNP
rs1459798599 1305 dbSNP
rs573297984 1305 dbSNP
rs1016486903 1306 dbSNP
rs1022987691 1309 dbSNP
rs569385726 1315 dbSNP
rs972229844 1319 dbSNP
rs1410164073 1322 dbSNP
rs1415648425 1324 dbSNP
rs1334067393 1347 dbSNP
rs919438277 1356 dbSNP
rs373472769 1369 dbSNP
rs139428466 1370 dbSNP
rs41307858 1382 dbSNP
rs1238898706 1387 dbSNP
rs934555721 1389 dbSNP
rs534636364 1393 dbSNP
rs916033810 1394 dbSNP
rs948682920 1408 dbSNP
rs1209984722 1415 dbSNP
rs144168650 1421 dbSNP
rs903750138 1422 dbSNP
rs936607699 1426 dbSNP
rs879450095 1428 dbSNP
rs574355697 1430 dbSNP
rs535089221 1431 dbSNP
rs228677 1433 dbSNP
rs892282802 1442 dbSNP
rs1232022711 1444 dbSNP
rs1457155129 1451 dbSNP
rs1179916937 1456 dbSNP
rs1234869245 1460 dbSNP
rs997396306 1463 dbSNP
rs943543585 1467 dbSNP
rs1178445183 1472 dbSNP
rs1030493533 1478 dbSNP
rs575043985 1486 dbSNP
rs545875496 1487 dbSNP
rs1177804855 1488 dbSNP
rs1037838245 1496 dbSNP
rs888872461 1508 dbSNP
rs1326421577 1511 dbSNP
rs1337205257 1520 dbSNP
rs1442529690 1521 dbSNP
rs1273684273 1523 dbSNP
rs1407994555 1525 dbSNP
rs769900060 1529 dbSNP
rs1225201107 1545 dbSNP
rs773109576 1549 dbSNP
rs1263748757 1555 dbSNP
rs1007199585 1556 dbSNP
rs1172261748 1575 dbSNP
rs1193904692 1587 dbSNP
rs1377772359 1602 dbSNP
rs1275339515 1609 dbSNP
rs376675419 1615 dbSNP
rs370822450 1616 dbSNP
rs1198449921 1618 dbSNP
rs963600628 1619 dbSNP
rs1376832382 1624 dbSNP
rs1481461906 1626 dbSNP
rs1200765140 1630 dbSNP
rs1334259261 1638 dbSNP
rs1423608029 1645 dbSNP
rs1444556072 1646 dbSNP
rs1169968110 1650 dbSNP
rs228678 1661 dbSNP
rs540446173 1662 dbSNP
rs1410129682 1669 dbSNP
rs1366946075 1682 dbSNP
rs1019419707 1684 dbSNP
rs960482077 1690 dbSNP
rs993013439 1691 dbSNP
rs562385573 1699 dbSNP
rs1225190300 1702 dbSNP
rs1014185971 1711 dbSNP
rs895846969 1711 dbSNP
rs1301212622 1712 dbSNP
rs1209395725 1713 dbSNP
rs1349964334 1716 dbSNP
rs915961632 1717 dbSNP
rs1211409455 1718 dbSNP
rs1289940199 1723 dbSNP
rs1023020246 1724 dbSNP
rs1271951993 1724 dbSNP
rs1435723008 1740 dbSNP
rs1262609148 1744 dbSNP
rs1206136639 1745 dbSNP
rs1427211118 1751 dbSNP
rs970126902 1758 dbSNP
rs978707899 1759 dbSNP
rs529572919 1765 dbSNP
rs925935153 1767 dbSNP
rs551039875 1778 dbSNP
rs773879119 1779 dbSNP
rs1052776532 1781 dbSNP
rs1380398869 1782 dbSNP
rs759047785 1784 dbSNP
rs1167708109 1789 dbSNP
rs1326800471 1797 dbSNP
rs988772795 1798 dbSNP
rs913861299 1799 dbSNP
rs933112098 1800 dbSNP
rs1313151317 1805 dbSNP
rs1051605504 1806 dbSNP
rs888841095 1811 dbSNP
rs1311961840 1812 dbSNP
rs1361811128 1812 dbSNP
rs1247020172 1821 dbSNP
rs1285329353 1822 dbSNP
rs1411894560 1828 dbSNP
rs1484938930 1828 dbSNP
rs1007334014 1836 dbSNP
rs562859629 1841 dbSNP
rs1329854463 1843 dbSNP
rs1037479648 1847 dbSNP
rs1442179402 1853 dbSNP
rs568252347 1854 dbSNP
rs993217496 1857 dbSNP
rs1387503851 1863 dbSNP
rs533297712 1864 dbSNP
rs776270589 1874 dbSNP
rs1354823147 1877 dbSNP
rs12731471 1885 dbSNP
rs1373116924 1886 dbSNP
rs1362644388 1892 dbSNP
rs960327049 1898 dbSNP
rs1451080567 1899 dbSNP
rs1290535974 1902 dbSNP
rs752257200 1906 dbSNP
rs566823331 1908 dbSNP
rs910981169 1909 dbSNP
rs1023106855 1924 dbSNP
rs534833299 1926 dbSNP
rs970221595 1929 dbSNP
rs978799809 1936 dbSNP
rs546347540 1937 dbSNP
rs761142130 1940 dbSNP
rs568015532 1945 dbSNP
rs1216083840 1949 dbSNP
rs1306646058 1949 dbSNP
rs1315192050 1950 dbSNP
rs535360304 1951 dbSNP
rs1038522108 1961 dbSNP
rs556581046 1962 dbSNP
rs1245287589 1964 dbSNP
rs929448191 1966 dbSNP
rs1183814981 1967 dbSNP
rs1467750032 1968 dbSNP
rs1047986100 1975 dbSNP
rs754192113 1977 dbSNP
rs1249453762 1979 dbSNP
rs1416760562 1980 dbSNP
rs933266485 1981 dbSNP
rs78859270 1988 dbSNP
rs896043259 1989 dbSNP
rs1051574904 2016 dbSNP
rs910369055 2017 dbSNP
rs1469305157 2018 dbSNP
rs1044337195 2023 dbSNP
rs1371497927 2025 dbSNP
rs757572705 2028 dbSNP
rs1393387536 2037 dbSNP
rs1307736252 2042 dbSNP
rs1344983857 2044 dbSNP
rs1222146890 2045 dbSNP
rs575162936 2046 dbSNP
rs769847304 2047 dbSNP
rs943213247 2054 dbSNP
rs539187208 2055 dbSNP
rs1476618279 2060 dbSNP
rs1324700586 2061 dbSNP
rs557859971 2066 dbSNP
rs1417488459 2078 dbSNP
rs572819226 2082 dbSNP
rs1000318332 2087 dbSNP
rs773253185 2088 dbSNP
rs1251822334 2092 dbSNP
rs1479861007 2092 dbSNP
rs993536147 2096 dbSNP
rs1460023242 2097 dbSNP
rs1047403434 2103 dbSNP
rs1470100028 2106 dbSNP
rs1169437410 2108 dbSNP
rs1352570589 2112 dbSNP
rs1167199620 2113 dbSNP
rs1463671436 2116 dbSNP
rs540840898 2118 dbSNP
rs1014439561 2119 dbSNP
rs1387304976 2121 dbSNP
rs1317612669 2124 dbSNP
rs892974428 2128 dbSNP
rs1346650374 2129 dbSNP
rs1033497824 2130 dbSNP
rs779121904 2132 dbSNP
rs1000361633 2139 dbSNP
rs1206175560 2141 dbSNP
rs1010047017 2143 dbSNP
rs1029595851 2145 dbSNP
rs1333717563 2146 dbSNP
rs749207123 2147 dbSNP
rs1033020984 2156 dbSNP
rs956157987 2163 dbSNP
rs185502918 2166 dbSNP
rs1417048539 2170 dbSNP
rs1204006806 2180 dbSNP
rs1260345213 2187 dbSNP
rs1449227604 2190 dbSNP
rs758454654 2202 dbSNP
rs1423008776 2203 dbSNP
rs955581436 2221 dbSNP
rs910925789 2224 dbSNP
rs1430558423 2229 dbSNP
rs373097936 2231 dbSNP
rs544902841 2237 dbSNP
rs973876695 2245 dbSNP
rs1167309257 2247 dbSNP
rs1215569573 2255 dbSNP
rs1418821443 2266 dbSNP
rs910510171 2270 dbSNP
rs780256882 2271 dbSNP
rs918310421 2282 dbSNP
rs1156887209 2284 dbSNP
rs1451682713 2290 dbSNP
rs562896002 2296 dbSNP
rs943144490 2298 dbSNP
rs1240344866 2300 dbSNP
rs973240078 2303 dbSNP
rs929504821 2307 dbSNP
rs920309967 2309 dbSNP
rs929087623 2314 dbSNP
rs1384402364 2332 dbSNP
rs1442945877 2346 dbSNP
rs1165705569 2351 dbSNP
rs1325172518 2352 dbSNP
rs1414620478 2356 dbSNP
rs1400251406 2360 dbSNP
rs1047957158 2362 dbSNP
rs1402314882 2368 dbSNP
rs538861713 2372 dbSNP
rs1432143355 2375 dbSNP
rs1336433918 2378 dbSNP
rs770436126 2380 dbSNP
rs1412559607 2387 dbSNP
rs1449932054 2389 dbSNP
rs949753948 2391 dbSNP
rs1316800404 2397 dbSNP
rs1294795558 2404 dbSNP
rs1222758165 2407 dbSNP
rs1282029843 2419 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gugugaguacaccGGGGGUCgu 5'
                       ||||| |  
Target 5' -------------CCCCCCGag 3'
 		1 - 9
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000377532.3 | 3UTR | CCCCCCGAGGGGGCUCUCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
321 hsa-miR-4731-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081189 MIDN midnolin 2 4
MIRT113400 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT153789 NCOA3 nuclear receptor coactivator 3 2 2
MIRT169837 GIGYF1 GRB10 interacting GYF protein 1 2 6
MIRT441540 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT443470 ACPP acid phosphatase, prostate 2 2
MIRT443851 RGS6 regulator of G protein signaling 6 2 2
MIRT444416 EMC1 ER membrane protein complex subunit 1 2 2
MIRT444838 PDE6D phosphodiesterase 6D 2 2
MIRT444997 HRH1 histamine receptor H1 2 2
MIRT446371 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT449696 SLC10A3 solute carrier family 10 member 3 2 2
MIRT451068 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451915 ILK integrin linked kinase 2 2
MIRT452990 CABP4 calcium binding protein 4 2 2
MIRT458034 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT460780 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT463916 WNT3 Wnt family member 3 2 2
MIRT465880 TMEM43 transmembrane protein 43 2 4
MIRT466317 THRA thyroid hormone receptor, alpha 2 2
MIRT468696 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT469129 RNF126 ring finger protein 126 2 2
MIRT472239 NFIC nuclear factor I C 2 2
MIRT479647 CD4 CD4 molecule 2 2
MIRT479734 CCND1 cyclin D1 2 6
MIRT479837 CCDC86 coiled-coil domain containing 86 2 2
MIRT483408 SPATA6 spermatogenesis associated 6 2 4
MIRT485972 RTBDN retbindin 2 2
MIRT486614 METTL6 methyltransferase like 6 2 2
MIRT487814 PER3 period circadian clock 3 2 2
MIRT488586 ST7L suppression of tumorigenicity 7 like 2 2
MIRT488673 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 2
MIRT490783 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT491356 PEX6 peroxisomal biogenesis factor 6 2 2
MIRT493539 IGDCC3 immunoglobulin superfamily DCC subclass member 3 2 4
MIRT493894 FAM43A family with sequence similarity 43 member A 2 4
MIRT494664 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT506353 NUP50 nucleoporin 50 2 6
MIRT508553 CEP72 centrosomal protein 72 2 4
MIRT508722 ZNF682 zinc finger protein 682 2 4
MIRT508811 GPR155 G protein-coupled receptor 155 2 2
MIRT509070 MED18 mediator complex subunit 18 2 2
MIRT509107 BMP8B bone morphogenetic protein 8b 2 6
MIRT509198 TTF2 transcription termination factor 2 2 2
MIRT509308 ZNF460 zinc finger protein 460 2 2
MIRT509341 ZNF708 zinc finger protein 708 2 2
MIRT509381 ASH2L ASH2 like histone lysine methyltransferase complex subunit 2 6
MIRT509722 EFCAB11 EF-hand calcium binding domain 11 2 4
MIRT510008 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 4
MIRT510067 C12orf49 chromosome 12 open reading frame 49 2 6
MIRT510179 BCL2L2 BCL2 like 2 2 2
MIRT511300 KIAA1551 KIAA1551 2 2
MIRT511531 HMGB1 high mobility group box 1 2 6
MIRT512018 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT514112 SERF2 small EDRK-rich factor 2 2 2
MIRT514296 FXYD5 FXYD domain containing ion transport regulator 5 2 6
MIRT514460 FANCA Fanconi anemia complementation group A 2 2
MIRT515183 CRCP CGRP receptor component 2 2
MIRT515290 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT515528 QRFPR pyroglutamylated RFamide peptide receptor 2 4
MIRT515553 TMEM134 transmembrane protein 134 2 2
MIRT515619 ISY1 ISY1 splicing factor homolog 2 2
MIRT515707 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT515988 SLC30A2 solute carrier family 30 member 2 2 2
MIRT516179 POLR3A RNA polymerase III subunit A 2 4
MIRT516247 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT516505 SYTL3 synaptotagmin like 3 2 4
MIRT516586 SPHAR S-phase response (cyclin related) 2 2
MIRT516697 ODF2L outer dense fiber of sperm tails 2 like 2 2
MIRT516779 PTRF caveolae associated protein 1 2 4
MIRT516998 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT517094 CCDC30 coiled-coil domain containing 30 2 4
MIRT517163 SLC28A1 solute carrier family 28 member 1 2 2
MIRT517234 PRIM1 DNA primase subunit 1 2 4
MIRT517602 SAV1 salvador family WW domain containing protein 1 2 2
MIRT517631 ZNF491 zinc finger protein 491 2 2
MIRT517734 C1orf220 chromosome 1 open reading frame 220 2 2
MIRT517748 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 4
MIRT518005 RPL4 ribosomal protein L4 2 4
MIRT518184 SLC27A4 solute carrier family 27 member 4 2 2
MIRT518266 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT518448 KIF6 kinesin family member 6 2 2
MIRT518679 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT518834 NEK8 NIMA related kinase 8 2 2
MIRT519142 C2orf49 chromosome 2 open reading frame 49 2 2
MIRT519250 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT519369 RBM28 RNA binding motif protein 28 2 2
MIRT519410 KCNA7 potassium voltage-gated channel subfamily A member 7 2 4
MIRT519495 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT520061 YIPF4 Yip1 domain family member 4 2 2
MIRT520132 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT520289 UBXN2A UBX domain protein 2A 2 2
MIRT520433 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT520553 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT520764 TCF23 transcription factor 23 2 2
MIRT520806 TAOK1 TAO kinase 1 2 2
MIRT520874 STX17 syntaxin 17 2 2
MIRT520986 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT521077 SLC25A15 solute carrier family 25 member 15 2 2
MIRT521165 SDHAF1 succinate dehydrogenase complex assembly factor 1 2 2
MIRT521213 SBNO1 strawberry notch homolog 1 2 2
MIRT521485 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT521638 PROSC pyridoxal phosphate binding protein 2 2
MIRT522151 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT522300 NKAP NFKB activating protein 2 2
MIRT522445 MOB4 MOB family member 4, phocein 2 2
MIRT522493 MFN1 mitofusin 1 2 2
MIRT522877 KHSRP KH-type splicing regulatory protein 2 2
MIRT523059 HYPK huntingtin interacting protein K 2 2
MIRT523095 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT523577 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT523634 FOXK1 forkhead box K1 2 4
MIRT524231 DCTN6 dynactin subunit 6 2 2
MIRT524266 CYCS cytochrome c, somatic 2 2
MIRT524367 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524430 CNKSR3 CNKSR family member 3 2 2
MIRT524557 CASP16 caspase 16, pseudogene 2 2
MIRT524585 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT524955 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT531856 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT541995 MYO1C myosin IC 2 2
MIRT542247 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT542601 YOD1 YOD1 deubiquitinase 2 2
MIRT545238 ZFAND3 zinc finger AN1-type containing 3 2 2
MIRT552183 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT553520 TMEM245 transmembrane protein 245 2 2
MIRT554430 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT559138 BTF3L4 basic transcription factor 3 like 4 2 4
MIRT564062 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT564857 ZBED3 zinc finger BED-type containing 3 2 2
MIRT565382 TGOLN2 trans-golgi network protein 2 2 2
MIRT568952 RUNX3 runt related transcription factor 3 2 2
MIRT568983 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569255 FAM129B family with sequence similarity 129 member B 2 2
MIRT570199 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT570913 PPFIA4 PTPRF interacting protein alpha 4 2 2
MIRT571084 ZNF670 zinc finger protein 670 2 2
MIRT571456 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574233 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT608730 MYH9 myosin heavy chain 9 2 2
MIRT610109 IL17REL interleukin 17 receptor E like 2 2
MIRT614235 WDR53 WD repeat domain 53 2 4
MIRT626199 PNRC1 proline rich nuclear receptor coactivator 1 2 4
MIRT626325 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT626381 BBS1 Bardet-Biedl syndrome 1 2 2
MIRT627164 ZNF48 zinc finger protein 48 2 2
MIRT633098 CBX5 chromobox 5 2 2
MIRT642246 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT643882 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT644837 SEC14L4 SEC14 like lipid binding 4 2 2
MIRT645189 POLR3F RNA polymerase III subunit F 2 4
MIRT645781 FFAR4 free fatty acid receptor 4 2 2
MIRT647144 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647273 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT648743 FAM46B family with sequence similarity 46 member B 2 2
MIRT649204 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT649859 WDR12 WD repeat domain 12 2 2
MIRT650814 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT659537 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT664212 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT664373 CYB5A cytochrome b5 type A 2 2
MIRT667395 MOB1B MOB kinase activator 1B 2 2
MIRT669465 ATL3 atlastin GTPase 3 2 2
MIRT670556 SHISA2 shisa family member 2 2 2
MIRT673104 MFSD2A major facilitator superfamily domain containing 2A 2 2
MIRT679350 LRG1 leucine rich alpha-2-glycoprotein 1 2 2
MIRT680354 GATAD1 GATA zinc finger domain containing 1 2 4
MIRT680680 ZNF785 zinc finger protein 785 2 2
MIRT680759 WDR73 WD repeat domain 73 2 2
MIRT681392 RMND1 required for meiotic nuclear division 1 homolog 2 2
MIRT681687 ABI2 abl interactor 2 2 2
MIRT681817 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT682314 RAB42 RAB42, member RAS oncogene family 2 2
MIRT683308 C19orf40 Fanconi anemia core complex associated protein 24 1 1
MIRT683374 ESR2 estrogen receptor 2 2 2
MIRT683466 CCS copper chaperone for superoxide dismutase 2 2
MIRT683481 ZNF7 zinc finger protein 7 2 2
MIRT683514 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT683860 OCIAD1 OCIA domain containing 1 2 2
MIRT683926 SLC43A3 solute carrier family 43 member 3 2 2
MIRT683935 MYLK3 myosin light chain kinase 3 2 2
MIRT684068 TLR7 toll like receptor 7 2 2
MIRT684120 CEP104 centrosomal protein 104 2 2
MIRT684192 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT684343 IFIT3 interferon induced protein with tetratricopeptide repeats 3 2 2
MIRT684480 GPR137B G protein-coupled receptor 137B 2 2
MIRT684565 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT684608 GTF2IRD2B GTF2I repeat domain containing 2B 2 2
MIRT684643 PDE4C phosphodiesterase 4C 2 2
MIRT684700 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT684735 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT684911 CD28 CD28 molecule 2 2
MIRT685024 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT685186 DCTN5 dynactin subunit 5 2 2
MIRT685234 F2RL1 F2R like trypsin receptor 1 2 2
MIRT685303 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT685345 CCL5 C-C motif chemokine ligand 5 2 2
MIRT685553 TXK TXK tyrosine kinase 2 2
MIRT685570 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT685651 C11orf1 chromosome 11 open reading frame 1 2 2
MIRT685697 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT685731 C12orf65 chromosome 12 open reading frame 65 2 2
MIRT685873 RTN2 reticulon 2 2 2
MIRT685937 PTGIS prostaglandin I2 synthase 2 2
MIRT686095 TNIP3 TNFAIP3 interacting protein 3 2 2
MIRT686147 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT686271 WWC1 WW and C2 domain containing 1 2 2
MIRT686307 VPS53 VPS53, GARP complex subunit 2 2
MIRT686349 USP15 ubiquitin specific peptidase 15 2 2
MIRT686377 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT686431 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT686477 TRIOBP TRIO and F-actin binding protein 2 2
MIRT686515 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT686682 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT686818 SLC7A11 solute carrier family 7 member 11 2 2
MIRT686904 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT686974 SERINC1 serine incorporator 1 2 2
MIRT687035 RNF115 ring finger protein 115 2 2
MIRT687067 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT687240 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT687494 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT687591 MANEAL mannosidase endo-alpha like 2 2
MIRT687635 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT687673 LMBR1L limb development membrane protein 1 like 2 2
MIRT687849 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT687918 HOOK3 hook microtubule tethering protein 3 2 2
MIRT687974 GTF2IRD2 GTF2I repeat domain containing 2 2 2
MIRT688105 GK5 glycerol kinase 5 (putative) 2 2
MIRT688115 GEMIN8 gem nuclear organelle associated protein 8 2 2
MIRT688148 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT688263 FAM213A family with sequence similarity 213 member A 2 2
MIRT688456 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT688497 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT688558 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT688668 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT689057 AGMAT agmatinase 2 2
MIRT689075 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT689108 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT689161 ZNF665 zinc finger protein 665 2 2
MIRT689788 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT689835 HIST1H2BJ histone cluster 1 H2B family member j 2 2
MIRT690061 MBD1 methyl-CpG binding domain protein 1 2 2
MIRT690727 IRAK4 interleukin 1 receptor associated kinase 4 2 2
MIRT690974 ZNF578 zinc finger protein 578 2 2
MIRT691066 NUGGC nuclear GTPase, germinal center associated 2 2
MIRT691315 KIAA1841 KIAA1841 2 2
MIRT691485 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT691568 CCDC125 coiled-coil domain containing 125 2 2
MIRT691601 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT692059 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT692099 CXorf38 chromosome X open reading frame 38 2 4
MIRT692311 RFK riboflavin kinase 2 2
MIRT692371 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT692432 METTL8 methyltransferase like 8 2 2
MIRT692468 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT692532 PARD3 par-3 family cell polarity regulator 2 2
MIRT692594 GDF5OS growth differentiation factor 5 opposite strand 2 2
MIRT692776 SYNPO2L synaptopodin 2 like 2 2
MIRT692810 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT692868 RBM41 RNA binding motif protein 41 2 2
MIRT693131 THEM4 thioesterase superfamily member 4 2 2
MIRT693313 TRIM58 tripartite motif containing 58 2 2
MIRT693497 MOB3A MOB kinase activator 3A 2 2
MIRT694101 ZNF446 zinc finger protein 446 2 2
MIRT694173 POLM DNA polymerase mu 2 2
MIRT694186 ZNF347 zinc finger protein 347 2 2
MIRT694444 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT694653 C14orf119 chromosome 14 open reading frame 119 2 2
MIRT694802 STX4 syntaxin 4 2 2
MIRT694922 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT695174 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695305 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 4
MIRT695656 MAN2B2 mannosidase alpha class 2B member 2 2 2
MIRT695823 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT695964 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT696174 GNB5 G protein subunit beta 5 2 2
MIRT696433 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT696610 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696854 UBOX5 U-box domain containing 5 2 2
MIRT696896 C14orf105 coiled-coil domain containing 198 2 2
MIRT697382 ZMAT3 zinc finger matrin-type 3 2 2
MIRT697529 ZBTB46 zinc finger and BTB domain containing 46 2 2
MIRT697973 TSPAN6 tetraspanin 6 2 2
MIRT698325 TMEM127 transmembrane protein 127 2 2
MIRT698915 SPEM1 spermatid maturation 1 2 2
MIRT699257 SLC6A4 solute carrier family 6 member 4 2 2
MIRT699311 SLC35F5 solute carrier family 35 member F5 2 4
MIRT699624 SH3BP5 SH3 domain binding protein 5 2 2
MIRT699688 SF3B3 splicing factor 3b subunit 3 2 2
MIRT700040 RPL14 ribosomal protein L14 2 2
MIRT700095 RNF19B ring finger protein 19B 2 2
MIRT700498 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 2
MIRT700747 PLAA phospholipase A2 activating protein 2 2
MIRT701103 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT701568 MYPN myopalladin 2 2
MIRT701692 MYADM myeloid associated differentiation marker 2 2
MIRT701815 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT702435 KIAA1549 KIAA1549 2 2
MIRT702518 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT702954 HIP1 huntingtin interacting protein 1 2 2
MIRT703079 GPRIN3 GPRIN family member 3 2 2
MIRT704106 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT704138 DNAL1 dynein axonemal light chain 1 2 2
MIRT704187 LDHD lactate dehydrogenase D 2 2
MIRT704754 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT705075 C4orf29 abhydrolase domain containing 18 2 2
MIRT705342 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT706274 SLC35F6 solute carrier family 35 member F6 2 2
MIRT706397 HAS2 hyaluronan synthase 2 2 2
MIRT706431 LIAS lipoic acid synthetase 2 2
MIRT706506 MTMR9 myotubularin related protein 9 2 2
MIRT707586 PCNXL2 pecanex homolog 2 2 2
MIRT708361 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 2
MIRT708444 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT709915 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT712607 BHLHA15 basic helix-loop-helix family member a15 2 2
MIRT716540 GOLGA2 golgin A2 2 2
MIRT721623 VDR vitamin D receptor 2 2
MIRT724887 MVK mevalonate kinase 2 2
MIRT725257 PARVB parvin beta 2 2
MIRT755885 RPLP0 ribosomal protein lateral stalk subunit P0 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4731 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4731 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4731 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4731-5p Anthracycline 30323 NSC82151 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Fluorouracil 3385 NSC19893 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Cyclophosphamide 2907 NSC26271 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Methotrexate 126941 NSC740 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Taxol 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-4731-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4731-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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