pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol CYP2W1   
Synonyms -
Description cytochrome P450 family 2 subfamily W member 1
Transcript NM_017781   
Expression
Putative miRNA Targets on CYP2W1
3'UTR of CYP2W1
(miRNA target sites are highlighted)
>CYP2W1|NM_017781|3'UTR
   1 GAGCTCCCCCAGCCCCCAGGTCCTCCTGACCACTCCCCTCCCAGCCCTGGGTCCTCCCACCCTCTCTCCTCCCACCCCAC
  81 AGCTCGGACTGCTCTGGGAGGGCCCTGAGGACTCCCACCCTCACCCCCACCCCCACAGGGTCAGCAACTGCTTCCGGTTA
 161 CACCCAGGACTACCCCTGCCCGACCCTGTGGGACCCCCACCCCTCTGATGCTGTCTGCAGCTCAGTCCCTGCCAGCCCCC
 241 AGGAGCGCCTCCAGGGCCCCGCCCACTCTCCCACCCCTGAAGCTGCACTCCCACCCACCTAGCTCCCCCCAGGGCCCCCC
 321 AGCACCTACAGCTGGGGCTGCAGGGAGACAACGGGTGGCTGCATCCAGCCAGAGACAGGCGCAGGTGGGTGTCCTCAGCG
 401 TGCGAGCCCTGCACCCCCCAGGTCCTGGGACTCCTGCAGACCCCACTCCATTCCCGCTCCTGGAACACTTCCTGCAGCTG
 481 TGCCTGGAGGCAGTCGGCCTGCAGTGCCAGACTCTGAGCCAAGCCACTGGGGCCATGCGTATGACTGGTGCAGGGAGGCA
 561 AGGCCCACATTCTCCTTCAGAGACAGGCACTGGCGCCAGAGGCTTCCTTGGGGCGGGGGGAGGGCACCTCAGCCCCTGAA
 641 GACAAGCAGCACTGCAGTGGCAAAAATGGAAACACTGACCCGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
 721 GGCCGAGGCAGGCGAATCACGAGGTCAGGAGTTCGAGACCAGCCTGCCCAACATGGTGAAACCCTGTCTCTACTAAAAAT
 801 ACAAAAAAATTAACCGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaggucccGGCUGGUGGGGUu 5'
                  ||  |||||||| 
Target 5' ccctctctCCTCCCACCCCAc 3'
60 - 80 149.00 -18.60
2
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            | :|||  |: ||||:|| 
Target 5' ggCGGGGGGAGGGCACCTCAg 3'
612 - 632 139.00 -23.40
3
miRNA  3' gaGGUCCCGG----CUGGUGGGGuu 5'
            ||||| ||    ||||||:||  
Target 5' ccCCAGGTCCTCCTGACCACTCCcc 3'
14 - 38 137.00 -25.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN23436942 298 COSMIC
COSN17078273 353 COSMIC
COSN17182973 382 COSMIC
COSN1339773 585 COSMIC
COSN17437147 622 COSMIC
COSN32250172 742 COSMIC
COSN24595059 756 COSMIC
COSN5093376 768 COSMIC
COSN25614661 810 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1168859320 1 dbSNP
rs1371841273 6 dbSNP
rs1407495369 8 dbSNP
rs1306713982 9 dbSNP
rs370165376 10 dbSNP
rs376213292 11 dbSNP
rs1433896536 12 dbSNP
rs1303775184 14 dbSNP
rs1310833857 15 dbSNP
rs1030464993 16 dbSNP
rs1275672348 17 dbSNP
rs1019273536 18 dbSNP
rs1398779688 19 dbSNP
rs1203183596 20 dbSNP
rs1274035376 22 dbSNP
rs1488729930 23 dbSNP
rs1192886635 25 dbSNP
rs1264937260 27 dbSNP
rs1432429686 34 dbSNP
rs1157446599 36 dbSNP
rs1188764072 37 dbSNP
rs955271727 38 dbSNP
rs1409226409 40 dbSNP
rs1032509182 52 dbSNP
rs1477176264 57 dbSNP
rs1271265283 68 dbSNP
rs986585959 70 dbSNP
rs910863010 72 dbSNP
rs942411596 74 dbSNP
rs1317406997 75 dbSNP
rs1277710688 78 dbSNP
rs1346693939 80 dbSNP
rs568088518 81 dbSNP
rs1283466498 82 dbSNP
rs1276980997 84 dbSNP
rs113978131 86 dbSNP
rs73261988 87 dbSNP
rs1346258673 89 dbSNP
rs945952314 93 dbSNP
rs577224197 102 dbSNP
rs1489420359 103 dbSNP
rs907051698 107 dbSNP
rs1191308339 116 dbSNP
rs1423827484 119 dbSNP
rs1430900677 122 dbSNP
rs546003485 125 dbSNP
rs1170124373 127 dbSNP
rs1177494756 128 dbSNP
rs938744359 129 dbSNP
rs1421622583 130 dbSNP
rs1430815022 132 dbSNP
rs1486164670 133 dbSNP
rs1207778223 134 dbSNP
rs1055912013 135 dbSNP
rs1353341666 136 dbSNP
rs553159711 143 dbSNP
rs1315660026 146 dbSNP
rs1056768783 155 dbSNP
rs1006260735 156 dbSNP
rs1016220359 157 dbSNP
rs1363273636 158 dbSNP
rs1284061455 160 dbSNP
rs573252264 165 dbSNP
rs1232131267 174 dbSNP
rs1300101727 176 dbSNP
rs1408844353 177 dbSNP
rs542347265 182 dbSNP
rs993724345 183 dbSNP
rs1270584135 184 dbSNP
rs1172660416 196 dbSNP
rs562047821 201 dbSNP
rs1413155252 203 dbSNP
rs1030435277 210 dbSNP
rs1222244358 236 dbSNP
rs1180116190 237 dbSNP
rs183047053 241 dbSNP
rs986944379 248 dbSNP
rs1018058763 255 dbSNP
rs964049805 256 dbSNP
rs1456195142 257 dbSNP
rs768995114 258 dbSNP
rs544218997 261 dbSNP
rs929270125 262 dbSNP
rs966343308 263 dbSNP
rs1287126893 264 dbSNP
rs1009459818 266 dbSNP
rs1316194623 276 dbSNP
rs564406715 286 dbSNP
rs1374974455 305 dbSNP
rs868301995 306 dbSNP
rs1417789307 310 dbSNP
rs1300179715 311 dbSNP
rs1462687445 312 dbSNP
rs1349417078 313 dbSNP
rs1162744045 314 dbSNP
rs1407387270 315 dbSNP
rs1426500144 315 dbSNP
rs1166152407 316 dbSNP
rs1021059431 323 dbSNP
rs928443784 329 dbSNP
rs1252387517 334 dbSNP
rs1177492762 335 dbSNP
rs967666815 336 dbSNP
rs1349744763 337 dbSNP
rs187334159 338 dbSNP
rs1362255918 339 dbSNP
rs1293052050 342 dbSNP
rs1240043772 344 dbSNP
rs1056278662 345 dbSNP
rs915958790 346 dbSNP
rs371134564 349 dbSNP
rs1434618938 350 dbSNP
rs1268587883 352 dbSNP
rs193101956 353 dbSNP
rs897848361 354 dbSNP
rs1366126646 355 dbSNP
rs1158032841 360 dbSNP
rs993693544 371 dbSNP
rs1365363414 375 dbSNP
rs1052053756 379 dbSNP
rs890612710 382 dbSNP
rs1432254621 393 dbSNP
rs919921970 397 dbSNP
rs1332568025 400 dbSNP
rs1490387958 401 dbSNP
rs549815123 404 dbSNP
rs748498766 409 dbSNP
rs528164657 411 dbSNP
rs1268176138 412 dbSNP
rs577289586 413 dbSNP
rs1049842106 414 dbSNP
rs533230757 415 dbSNP
rs1311833131 419 dbSNP
rs772514228 420 dbSNP
rs1190609883 427 dbSNP
rs773797499 438 dbSNP
rs1011346677 439 dbSNP
rs1040625761 445 dbSNP
rs1473981848 456 dbSNP
rs901654407 457 dbSNP
rs1289258467 465 dbSNP
rs1417847362 467 dbSNP
rs1021280171 470 dbSNP
rs1375582991 478 dbSNP
rs1460309630 485 dbSNP
rs1480543477 488 dbSNP
rs967062303 496 dbSNP
rs903555881 497 dbSNP
rs1000530616 515 dbSNP
rs1456736193 515 dbSNP
rs1033452623 517 dbSNP
rs991893388 519 dbSNP
rs1324510831 523 dbSNP
rs1342425870 531 dbSNP
rs1025580271 535 dbSNP
rs961527464 537 dbSNP
rs1448552165 539 dbSNP
rs977328004 540 dbSNP
rs371837394 542 dbSNP
rs920168187 548 dbSNP
rs931339305 555 dbSNP
rs1338434671 557 dbSNP
rs985416087 558 dbSNP
rs1399043722 570 dbSNP
rs1167923908 579 dbSNP
rs960232102 581 dbSNP
rs1476076869 588 dbSNP
rs1373141690 591 dbSNP
rs1194600710 592 dbSNP
rs761018416 595 dbSNP
rs183944138 596 dbSNP
rs1327904177 609 dbSNP
rs1185759128 610 dbSNP
rs991303260 615 dbSNP
rs551395751 616 dbSNP
rs187651886 617 dbSNP
rs945222720 618 dbSNP
rs928001218 622 dbSNP
rs1042736283 629 dbSNP
rs1316942001 634 dbSNP
rs1037775660 636 dbSNP
rs775987707 644 dbSNP
rs1375711950 646 dbSNP
rs1442630260 651 dbSNP
rs1326513849 654 dbSNP
rs919247229 659 dbSNP
rs1211349020 664 dbSNP
rs1396640491 670 dbSNP
rs376394360 671 dbSNP
rs759255464 676 dbSNP
rs1185008688 679 dbSNP
rs192784493 682 dbSNP
rs539790552 683 dbSNP
rs1179979841 687 dbSNP
rs138843003 688 dbSNP
rs1013754646 689 dbSNP
rs527617261 697 dbSNP
rs1209274004 699 dbSNP
rs183714381 706 dbSNP
rs1293786240 707 dbSNP
rs7811147 710 dbSNP
rs1352802186 711 dbSNP
rs967031258 712 dbSNP
rs1443983150 715 dbSNP
rs758215479 716 dbSNP
rs1411388714 723 dbSNP
rs575348526 725 dbSNP
rs952979969 730 dbSNP
rs544186778 734 dbSNP
rs564170001 735 dbSNP
rs62433131 736 dbSNP
rs1157143659 741 dbSNP
rs1471298610 750 dbSNP
rs959954933 755 dbSNP
rs991833268 756 dbSNP
rs1364534727 760 dbSNP
rs1198272904 767 dbSNP
rs1489897759 774 dbSNP
rs915728287 783 dbSNP
rs549811394 786 dbSNP
rs1236325874 789 dbSNP
rs751519307 793 dbSNP
rs1276102822 801 dbSNP
rs188871226 815 dbSNP
rs1487907608 816 dbSNP
rs973452699 817 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaggucccggcuGGUGGGGuu 5'
                      ||||||:  
Target 5' ----------ucCCACCCUcu 3'
1 - 11
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 54905.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaggucccggcuGGUGGGGuu 5'
                      ||||||:  
Target 5' ---------cucCCACCCUcu 3'
1 - 12
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000340150.6 | 3UTR | UCCCACCCUCUCUCCUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000340150.6 | 3UTR | CUCCCACCCUCUCUCCUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000340150.6 | 3UTR | CUCCCACCCUCUCUCCUCCCACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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