miRTarBase - #MIRT489557


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pre-miRNA Information
pre-miRNA hsa-mir-6867   
Genomic Coordinates chr17: 40193597 - 40193663
Description Homo sapiens miR-6867 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6867-3p
Sequence 47| CUCUCCCUCUUUACCCACUAG |67
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7811173 21 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1403216522 1 dbSNP
rs781776276 3 dbSNP
rs202050374 4 dbSNP
rs367842831 5 dbSNP
rs1223489976 6 dbSNP
rs907256096 9 dbSNP
rs753257137 14 dbSNP
rs757843554 17 dbSNP
rs371369162 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PLD6   
Synonyms ZUC
Description phospholipase D family member 6
Transcript NM_178836   
Expression
Putative miRNA Targets on PLD6
3'UTR of PLD6
(miRNA target sites are highlighted)		 
>PLD6|NM_178836|3'UTR
   1 CCAAGAATGGGGCTGAGCCCTCCCTGCGGGCTGCTGTGCGTTCTGAGGGAGGGAGACCTCGGCACTAGAAAAAAATCGTT
  81 AAACTAAAGTCTCGTCTATTAGAATACTAAATTGAACTAAAGAAGGTTAGGAAAGGGAAATTTCTGTTACTTCGGGTCAG
 161 TTATTTCGGGCCAGACCTTTTTCTTGCTCCTTTGCCAAAATAACTTCAGTCACGACCTGCCACGGGGTGCTTTCATGAGT
 241 GTGGTCCGTATCTTGGTTTGGAATCGAAACTTCTGCTACAGCACAGAAAAGGCACAGTGCCTCTTCCAGGTCGATCCCAT
 321 TCCCTTCCCTGATTCTAGAAAAGTCCCTCCTGCTTTGGCTGATGTGGGCCCTTTCAGCATCTCCCTGAGATTTCATCCCT
 401 CTCTCCATGTGGCACGACTGGGGTTGGTTGGGGCCTACAGTCTCCTTGTCCCTCACAGTCTGCCCCTGTCAGGGCTCGGT
 481 CCTCAGAGTAAGGAAAGGAAATGGAAGTCAGGAGGAAGGGAAGATGTGAGTGTGCGGTGCGGGTGGCAAAAGCAGCCTTC
 561 GGGGCAACCCCGTGAGCGTCATTGCCACCAAAGGCTGGCTGTTCCCTTGATTCCTTGCATAATTGCTCTTTAAAACCAGT
 641 ATGCACGCCAGTGCCAAGCTCTTCAGCAGCCTGTCCTTGGGTAGTAAGTGCTGTGGTCTGTCAGGACTGATGGCCAGCAG
 721 CTGTTTCTATGTTGGGCTTTTAACTTTTTTTATTTTATTTATTTATTTATTTATCTTTTTTGAGATGGAGTCTCACTCTG
 801 TGGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGCTCACTGCATCCTCTGCCTCCTGGGTTCAAACGATTGTCCTGCCTC
 881 AGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACAACACCTGGCTGATTTTTTTTTTGGTATTTTTAGTAGAGACAG
 961 GGTTTCACCATGTTGGTTAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCACTTCCGCCTCCCAAAGTGCTGGGA
1041 TTACAGGTGTGAGCCGCCATGCCCGGCCGGGCTTTTAACTTTTAATGTCCTAATGTTAAGGTAATTTTGTTGTGTGTTTA
1121 GAAGTGACCTTACCTTTAACACCTGTGGAGTTAGTGCGTGCACATTGCTGGCTCAGCGTAACCCATCACGGGACCGGAGG
1201 AGAGGAGAGCGGGGAAGAGGAGAGCAGCTTCAGGCCGTGGTGTCTCCCACGTCTGTGTTCTTATTTGCAGCTCAGGGTTT
1281 GCATTCCCAGGTAGAACAGGTGTCGTACACTGTGAAATGTTCCAGGTTATTTGTTTATAATGTGTGTGTCATATACAGAT
1361 AGCTCCGATGACATCTGAAGTTGTGACTTCATCATCTTGTCATATTTCTGTATGATGAGCCCCAGGGCCCATCCTGAGGT
1441 CTGCTAGCCATGTGCTTAGTCTCACCTCCCCAGCCCACGCTGGCATTACCACCCAGAGACCCTTCAGTGCTGTGTGTTTT
1521 TCCTTTTTAGGGTTACTTTTGACTCACAGTGTTAGGCAAGCCAGCTTGGAAGTTAACTTTTAAAAAAATTCAATTGAAGC
1601 TGTAAAGTATAATATATAGATTGGAAGTCACCAGAAATTGTTTTAGTTTGTGAATTCCCCCAGTGTATGTTCTGAAAAGA
1681 AAATGGGAGAGCTTGTAAAGCATCTCCTAAATGCGAAGCCGCGTGACCCTGGACTTCTGGCACATCTGAATAAACATGTT
1761 CTTATTCTGGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauCACCCA----UUUCUCCCUCUc 5'
             ||| ||    |::|||||||| 
Target 5' gctGTGCGTTCTGAGGGAGGGAGAc 3'
 33 - 57 160.00 -21.90
2 
miRNA  3' gaUCACCCAUUUC--UCCCUCUc 5'
            ||  ||| |:|  ||||| | 
Target 5' aaAGAAGGTTAGGAAAGGGAAAt 3'
 119 - 141 125.00 -10.12
3 
miRNA  3' gaUCACCCAUUUCUCCC-UCUc 5'
            |||  | |:: |||| ||| 
Target 5' gaAGTCAGGAGGAAGGGAAGAt 3'
 504 - 525 123.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30535325 20 COSMIC
COSN13703205 77 COSMIC
COSN31564307 78 COSMIC
COSN6099940 541 COSMIC
COSN31961287 682 COSMIC
COSN27071039 738 COSMIC
COSN29595309 930 COSMIC
COSN19531105 1248 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770101410 1 dbSNP
rs1431894236 2 dbSNP
rs373284736 7 dbSNP
rs781642633 11 dbSNP
rs943071123 12 dbSNP
rs1417872259 18 dbSNP
rs755548668 19 dbSNP
rs1473976455 20 dbSNP
rs1273060710 24 dbSNP
rs764692117 25 dbSNP
rs1421529007 26 dbSNP
rs752105442 27 dbSNP
rs34585164 28 dbSNP
rs1231220573 33 dbSNP
rs1437624079 35 dbSNP
rs1240174174 36 dbSNP
rs374821991 38 dbSNP
rs201261287 39 dbSNP
rs539485372 40 dbSNP
rs770815360 40 dbSNP
rs1274103121 49 dbSNP
rs1235088870 51 dbSNP
rs1276570082 53 dbSNP
rs1342703070 57 dbSNP
rs1218440588 60 dbSNP
rs946766054 61 dbSNP
rs915328731 62 dbSNP
rs925551289 65 dbSNP
rs974680680 73 dbSNP
rs138353668 75 dbSNP
rs1468554091 78 dbSNP
rs867488663 78 dbSNP
rs146329647 82 dbSNP
rs1172496094 86 dbSNP
rs1459127700 89 dbSNP
rs918116357 89 dbSNP
rs74604015 93 dbSNP
rs568998769 94 dbSNP
rs1441776174 96 dbSNP
rs767655024 98 dbSNP
rs761897599 101 dbSNP
rs973265108 104 dbSNP
rs984799919 105 dbSNP
rs1378520125 107 dbSNP
rs1280035524 121 dbSNP
rs374016688 123 dbSNP
rs548914394 136 dbSNP
rs528951219 138 dbSNP
rs1226289246 139 dbSNP
rs2270400 141 dbSNP
rs1026211506 144 dbSNP
rs774633657 152 dbSNP
rs1284927629 153 dbSNP
rs769568902 154 dbSNP
rs1333919789 160 dbSNP
rs141992360 164 dbSNP
rs540646113 167 dbSNP
rs75836479 168 dbSNP
rs1411522322 169 dbSNP
rs1162319630 172 dbSNP
rs555087518 178 dbSNP
rs1388715781 188 dbSNP
rs1004173095 189 dbSNP
rs1329476526 195 dbSNP
rs776521845 197 dbSNP
rs1413879439 200 dbSNP
rs1352210451 204 dbSNP
rs1407767146 208 dbSNP
rs1287427073 211 dbSNP
rs765576249 213 dbSNP
rs1007402633 214 dbSNP
rs888834901 216 dbSNP
rs902782425 223 dbSNP
rs564605022 227 dbSNP
rs1195821607 231 dbSNP
rs1042910636 235 dbSNP
rs1484285019 240 dbSNP
rs1203612640 242 dbSNP
rs1251630329 243 dbSNP
rs1231705231 247 dbSNP
rs946912865 248 dbSNP
rs1366883998 249 dbSNP
rs544864507 251 dbSNP
rs893890729 255 dbSNP
rs1168499652 263 dbSNP
rs1039118305 265 dbSNP
rs1307338368 266 dbSNP
rs945606676 267 dbSNP
rs1397543060 268 dbSNP
rs575865318 273 dbSNP
rs943362438 277 dbSNP
rs911864860 278 dbSNP
rs1240481585 280 dbSNP
rs987510057 282 dbSNP
rs1212056757 283 dbSNP
rs1321358751 284 dbSNP
rs1226892788 289 dbSNP
rs929176847 293 dbSNP
rs138814126 295 dbSNP
rs1483794086 307 dbSNP
rs1230118673 308 dbSNP
rs1348402988 312 dbSNP
rs1308400449 313 dbSNP
rs985304275 318 dbSNP
rs1441997755 331 dbSNP
rs1189444632 333 dbSNP
rs973638583 340 dbSNP
rs143216890 350 dbSNP
rs1447705551 352 dbSNP
rs1167940880 365 dbSNP
rs963244799 366 dbSNP
rs1378085554 369 dbSNP
rs369828180 380 dbSNP
rs1300797050 384 dbSNP
rs73981904 394 dbSNP
rs959788141 398 dbSNP
rs4985749 399 dbSNP
rs149222494 401 dbSNP
rs967330821 403 dbSNP
rs1398424479 406 dbSNP
rs1379209851 407 dbSNP
rs570795883 415 dbSNP
rs557092342 423 dbSNP
rs538101919 425 dbSNP
rs1235902188 426 dbSNP
rs1254684099 436 dbSNP
rs1382488657 437 dbSNP
rs953234498 438 dbSNP
rs1209643231 439 dbSNP
rs747698310 439 dbSNP
rs1250113954 440 dbSNP
rs1192158616 448 dbSNP
rs569060906 463 dbSNP
rs1032746522 464 dbSNP
rs1011473606 465 dbSNP
rs9908205 466 dbSNP
rs1224104193 468 dbSNP
rs1039192136 477 dbSNP
rs1007576742 478 dbSNP
rs1445330622 481 dbSNP
rs1285470901 483 dbSNP
rs566776158 488 dbSNP
rs890544497 493 dbSNP
rs1389103181 496 dbSNP
rs1299784768 499 dbSNP
rs1330940547 508 dbSNP
rs1229345963 513 dbSNP
rs1270288010 515 dbSNP
rs552665626 517 dbSNP
rs1240780907 519 dbSNP
rs1052166543 520 dbSNP
rs535823116 535 dbSNP
rs1266173217 536 dbSNP
rs796642410 537 dbSNP
rs919168214 540 dbSNP
rs1037645704 554 dbSNP
rs559986261 560 dbSNP
rs754293786 561 dbSNP
rs915717435 562 dbSNP
rs529142509 564 dbSNP
rs112756415 572 dbSNP
rs1428288679 576 dbSNP
rs369443459 577 dbSNP
rs566558693 578 dbSNP
rs1298284267 586 dbSNP
rs928411528 590 dbSNP
rs1049241757 594 dbSNP
rs919352948 597 dbSNP
rs972026013 601 dbSNP
rs977483905 604 dbSNP
rs376958388 605 dbSNP
rs1349004199 606 dbSNP
rs1385797570 607 dbSNP
rs1363024388 608 dbSNP
rs1323603315 615 dbSNP
rs1219413359 619 dbSNP
rs1174343755 623 dbSNP
rs1483306660 629 dbSNP
rs967109293 631 dbSNP
rs7212534 637 dbSNP
rs1249430271 643 dbSNP
rs1472125785 646 dbSNP
rs1182138672 647 dbSNP
rs138312741 659 dbSNP
rs564077426 661 dbSNP
rs958301706 664 dbSNP
rs1193121317 667 dbSNP
rs866096207 673 dbSNP
rs1431013487 680 dbSNP
rs1262481697 686 dbSNP
rs184532940 692 dbSNP
rs1369147239 702 dbSNP
rs1489207995 704 dbSNP
rs953228422 707 dbSNP
rs1278061997 714 dbSNP
rs1007691073 715 dbSNP
rs1000032971 716 dbSNP
rs890534712 723 dbSNP
rs1312544484 727 dbSNP
rs1342953870 737 dbSNP
rs756638588 742 dbSNP
rs531230180 750 dbSNP
rs993885573 751 dbSNP
rs1238852533 752 dbSNP
rs1339465337 752 dbSNP
rs897852781 757 dbSNP
rs1020065130 761 dbSNP
rs1401335755 761 dbSNP
rs34674814 771 dbSNP
rs1013871990 775 dbSNP
rs35571214 775 dbSNP
rs1388812497 776 dbSNP
rs1038118845 782 dbSNP
rs1353061781 787 dbSNP
rs1409753642 788 dbSNP
rs895509039 790 dbSNP
rs755613315 799 dbSNP
rs1466028930 812 dbSNP
rs562284242 824 dbSNP
rs2102645 825 dbSNP
rs1049656392 828 dbSNP
rs1055601898 830 dbSNP
rs930835546 832 dbSNP
rs1464212122 833 dbSNP
rs374866676 840 dbSNP
rs1423221543 849 dbSNP
rs919329259 852 dbSNP
rs1036489406 859 dbSNP
rs938529145 864 dbSNP
rs562795054 866 dbSNP
rs1248205567 867 dbSNP
rs1465884418 871 dbSNP
rs35962147 887 dbSNP
rs986146363 888 dbSNP
rs111301344 889 dbSNP
rs967545340 897 dbSNP
rs914220305 900 dbSNP
rs375645942 907 dbSNP
rs1176009151 910 dbSNP
rs1389605038 911 dbSNP
rs1257485739 916 dbSNP
rs1458891920 920 dbSNP
rs1318558919 931 dbSNP
rs77062253 931 dbSNP
rs1202215215 932 dbSNP
rs1325921752 932 dbSNP
rs1437193430 940 dbSNP
rs1276515334 941 dbSNP
rs796457194 941 dbSNP
rs1316873221 942 dbSNP
rs958251393 950 dbSNP
rs1017847985 951 dbSNP
rs774435104 957 dbSNP
rs986262856 958 dbSNP
rs545858708 962 dbSNP
rs1330697502 963 dbSNP
rs992565225 963 dbSNP
rs959794329 969 dbSNP
rs954926481 972 dbSNP
rs1220140399 976 dbSNP
rs1200255711 988 dbSNP
rs1477263249 989 dbSNP
rs1033937992 995 dbSNP
rs1030817306 1003 dbSNP
rs993564717 1007 dbSNP
rs1001226432 1010 dbSNP
rs897921228 1014 dbSNP
rs1027934472 1021 dbSNP
rs1311470852 1022 dbSNP
rs1325479144 1029 dbSNP
rs1016232810 1042 dbSNP
rs1347976941 1043 dbSNP
rs1395886647 1045 dbSNP
rs1288810677 1046 dbSNP
rs1352091021 1047 dbSNP
rs1006232683 1049 dbSNP
rs577274233 1051 dbSNP
rs532022262 1054 dbSNP
rs1055759771 1055 dbSNP
rs1356462343 1056 dbSNP
rs537097473 1064 dbSNP
rs1171638083 1065 dbSNP
rs938476732 1068 dbSNP
rs764343592 1069 dbSNP
rs1041960793 1071 dbSNP
rs771350371 1073 dbSNP
rs575487127 1083 dbSNP
rs914315574 1091 dbSNP
rs1258222595 1100 dbSNP
rs1179994222 1112 dbSNP
rs1363391740 1125 dbSNP
rs759306864 1128 dbSNP
rs1320041421 1130 dbSNP
rs1165015052 1134 dbSNP
rs978743008 1138 dbSNP
rs776364232 1145 dbSNP
rs942411928 1150 dbSNP
rs1308527156 1153 dbSNP
rs1328933469 1158 dbSNP
rs945863357 1159 dbSNP
rs910788873 1170 dbSNP
rs1327807568 1175 dbSNP
rs913034109 1176 dbSNP
rs573892649 1177 dbSNP
rs986372633 1178 dbSNP
rs117585493 1180 dbSNP
rs777764000 1189 dbSNP
rs972643307 1190 dbSNP
rs866431706 1194 dbSNP
rs144305480 1195 dbSNP
rs1028317852 1196 dbSNP
rs566646703 1197 dbSNP
rs34090080 1199 dbSNP
rs1171779860 1205 dbSNP
rs552745212 1207 dbSNP
rs1379567063 1210 dbSNP
rs898085908 1211 dbSNP
rs1472322832 1212 dbSNP
rs752603875 1214 dbSNP
rs1427587391 1217 dbSNP
rs1167048400 1219 dbSNP
rs1402628916 1221 dbSNP
rs1295871379 1226 dbSNP
rs115415960 1236 dbSNP
rs894503245 1237 dbSNP
rs73981903 1250 dbSNP
rs113226840 1251 dbSNP
rs1050525213 1255 dbSNP
rs1344862942 1259 dbSNP
rs1225855176 1262 dbSNP
rs907118191 1264 dbSNP
rs931975185 1281 dbSNP
rs1278437692 1289 dbSNP
rs1041519397 1297 dbSNP
rs1202450702 1304 dbSNP
rs1261439893 1304 dbSNP
rs945905810 1304 dbSNP
rs1342494888 1305 dbSNP
rs767919817 1307 dbSNP
rs892885837 1309 dbSNP
rs201990853 1312 dbSNP
rs942359733 1317 dbSNP
rs910856228 1342 dbSNP
rs13014 1343 dbSNP
rs1378035067 1350 dbSNP
rs1467372918 1350 dbSNP
rs747760624 1356 dbSNP
rs1050734191 1361 dbSNP
rs1457319816 1362 dbSNP
rs945946426 1363 dbSNP
rs530456657 1366 dbSNP
rs14003 1367 dbSNP
rs116443325 1368 dbSNP
rs1215004436 1375 dbSNP
rs962561296 1388 dbSNP
rs1295467888 1390 dbSNP
rs1332064282 1394 dbSNP
rs909276691 1396 dbSNP
rs1235830185 1397 dbSNP
rs112995777 1404 dbSNP
rs1310392351 1406 dbSNP
rs75677032 1412 dbSNP
rs1209583932 1414 dbSNP
rs1270167633 1425 dbSNP
rs1484916767 1429 dbSNP
rs984901942 1430 dbSNP
rs1241669525 1440 dbSNP
rs958795919 1446 dbSNP
rs1434722492 1456 dbSNP
rs1329756521 1458 dbSNP
rs1196938053 1464 dbSNP
rs1300815111 1469 dbSNP
rs1387616787 1477 dbSNP
rs979914622 1478 dbSNP
rs112280419 1479 dbSNP
rs1296423375 1480 dbSNP
rs559480059 1482 dbSNP
rs1034312036 1484 dbSNP
rs1342971929 1485 dbSNP
rs189614132 1489 dbSNP
rs1288828930 1491 dbSNP
rs868678819 1495 dbSNP
rs1391996290 1512 dbSNP
rs1160194021 1540 dbSNP
rs1476906378 1545 dbSNP
rs1281840806 1549 dbSNP
rs1345269275 1553 dbSNP
rs1229287086 1554 dbSNP
rs1290425889 1557 dbSNP
rs962262180 1558 dbSNP
rs1238374024 1561 dbSNP
rs1015216454 1570 dbSNP
rs1489455356 1571 dbSNP
rs1376917017 1572 dbSNP
rs879181249 1581 dbSNP
rs1009053020 1582 dbSNP
rs1220149705 1582 dbSNP
rs1483245982 1589 dbSNP
rs971333218 1591 dbSNP
rs76529652 1592 dbSNP
rs1020662010 1593 dbSNP
rs577264760 1611 dbSNP
rs1260336685 1614 dbSNP
rs1427183804 1615 dbSNP
rs996243375 1622 dbSNP
rs1010055692 1625 dbSNP
rs904609475 1629 dbSNP
rs538663133 1639 dbSNP
rs1043039201 1647 dbSNP
rs1410773034 1650 dbSNP
rs1300151042 1654 dbSNP
rs893003915 1655 dbSNP
rs754725160 1656 dbSNP
rs1313611102 1661 dbSNP
rs1323546147 1664 dbSNP
rs563673749 1668 dbSNP
rs543784603 1681 dbSNP
rs574769098 1694 dbSNP
rs1243743077 1701 dbSNP
rs1290880334 1711 dbSNP
rs1342648620 1712 dbSNP
rs1057000762 1714 dbSNP
rs555027988 1715 dbSNP
rs1006568880 1720 dbSNP
rs57606609 1722 dbSNP
rs1194454766 1727 dbSNP
rs1050748514 1731 dbSNP
rs1343293281 1732 dbSNP
rs919686852 1735 dbSNP
rs1172918360 1740 dbSNP
rs1234148602 1745 dbSNP
rs1441801051 1749 dbSNP
rs1347634270 1751 dbSNP
rs553159051 1756 dbSNP
rs1450488516 1757 dbSNP
rs1314298518 1758 dbSNP
rs961057971 1761 dbSNP
rs1216240599 1767 dbSNP
rs539293512 1768 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaucacccaUUUCUCCCUCUc 5'
                   |::|||||||| 
Target 5' ------cugAGGGAGGGAGAc 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000321560.3 | 3UTR | CUGAGGGAGGGAGACCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
203 hsa-miR-6867-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078229 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT107799 SLC1A1 solute carrier family 1 member 1 2 2
MIRT115808 CAPN15 calpain 15 2 2
MIRT137570 RCOR1 REST corepressor 1 2 2
MIRT161372 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT320477 HOXA10 homeobox A10 2 2
MIRT444449 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT461305 MRPS27 mitochondrial ribosomal protein S27 2 6
MIRT470306 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT471679 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT475546 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 2
MIRT480901 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT489368 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489557 PLD6 phospholipase D family member 6 2 2
MIRT494969 TMEM233 transmembrane protein 233 2 2
MIRT496634 SLC46A1 solute carrier family 46 member 1 2 2
MIRT500259 ZNF788 zinc finger family member 788 2 6
MIRT500272 ZNF781 zinc finger protein 781 2 8
MIRT500328 ZNF487P zinc finger protein 487 1 3
MIRT504012 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT504830 EREG epiregulin 2 2
MIRT513588 DCTN6 dynactin subunit 6 2 2
MIRT520896 STMN1 stathmin 1 2 2
MIRT525275 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT526166 ANKRD65 ankyrin repeat domain 65 2 2
MIRT526582 CCDC43 coiled-coil domain containing 43 2 2
MIRT527812 TMEM74B transmembrane protein 74B 2 2
MIRT528141 LRRC38 leucine rich repeat containing 38 2 2
MIRT529903 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531980 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT532251 TBPL2 TATA-box binding protein like 2 2 2
MIRT534300 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT534879 QKI QKI, KH domain containing RNA binding 2 2
MIRT538305 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT539385 ADRB1 adrenoceptor beta 1 2 2
MIRT541304 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT543960 RNF20 ring finger protein 20 2 2
MIRT544380 ZNF266 zinc finger protein 266 2 2
MIRT544451 KRBOX4 KRAB box domain containing 4 2 2
MIRT545783 ZNF791 zinc finger protein 791 2 4
MIRT548156 FRAT2 FRAT2, WNT signaling pathway regulator 2 2
MIRT556660 KMT2D lysine methyltransferase 2D 2 4
MIRT557715 GABARAPL1 GABA type A receptor associated protein like 1 2 2
MIRT562701 ZNF415 zinc finger protein 415 2 2
MIRT563050 ZNF138 zinc finger protein 138 2 2
MIRT564307 CCNT1 cyclin T1 2 2
MIRT568333 BACH1 BTB domain and CNC homolog 1 2 2
MIRT570864 ZNF525 zinc finger protein 525 2 2
MIRT570874 ZFP1 ZFP1 zinc finger protein 2 2
MIRT571516 ZNF625 zinc finger protein 625 2 2
MIRT572470 MTMR10 myotubularin related protein 10 2 2
MIRT572898 RUNDC3B RUN domain containing 3B 2 2
MIRT573084 APLN apelin 2 2
MIRT575251 Timp3 tissue inhibitor of metalloproteinase 3 2 2
MIRT575275 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT607230 LINS lines homolog 1 2 4
MIRT611803 FCRL4 Fc receptor like 4 2 2
MIRT612669 POU2F1 POU class 2 homeobox 1 2 4
MIRT612739 MYOCD myocardin 2 2
MIRT613409 CDH8 cadherin 8 2 4
MIRT614007 PAOX polyamine oxidase 2 2
MIRT615188 CLUAP1 clusterin associated protein 1 2 2
MIRT616497 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT616524 URM1 ubiquitin related modifier 1 2 2
MIRT617066 SPIB Spi-B transcription factor 2 2
MIRT617813 EMX2 empty spiracles homeobox 2 2 2
MIRT619291 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619375 KLHL12 kelch like family member 12 2 2
MIRT619499 TXLNB taxilin beta 2 2
MIRT619601 MKKS McKusick-Kaufman syndrome 2 2
MIRT619754 MYO1F myosin IF 2 2
MIRT619976 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT620743 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT620871 KCTD7 potassium channel tetramerization domain containing 7 2 2
MIRT621380 CLNK cytokine dependent hematopoietic cell linker 2 2
MIRT621511 ZNF638 zinc finger protein 638 2 2
MIRT621537 ZNF500 zinc finger protein 500 2 2
MIRT621772 TMEM87B transmembrane protein 87B 2 2
MIRT622193 SLC5A12 solute carrier family 5 member 12 2 2
MIRT622319 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT622738 PITPNM3 PITPNM family member 3 2 2
MIRT622996 ONECUT3 one cut homeobox 3 2 2
MIRT625301 SHISA6 shisa family member 6 2 2
MIRT625637 KCNQ3 potassium voltage-gated channel subfamily Q member 3 2 2
MIRT627698 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT627751 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT628438 ANTXR2 anthrax toxin receptor 2 2 2
MIRT635440 SLC25A44 solute carrier family 25 member 44 2 2
MIRT637166 TMEM50A transmembrane protein 50A 2 2
MIRT638207 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT639288 TFAP2A transcription factor AP-2 alpha 2 4
MIRT639398 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT641230 SEMA3E semaphorin 3E 2 2
MIRT641501 STC2 stanniocalcin 2 2 2
MIRT642577 PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2 2
MIRT642735 TDRD6 tudor domain containing 6 2 2
MIRT644001 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644210 CBS cystathionine-beta-synthase 2 2
MIRT645405 FAM110A family with sequence similarity 110 member A 2 2
MIRT645685 TBC1D13 TBC1 domain family member 13 2 2
MIRT645699 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT645761 SURF6 surfeit 6 2 2
MIRT645826 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT645914 PLXNA3 plexin A3 2 2
MIRT646167 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646634 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT647547 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT648262 ZNF582 zinc finger protein 582 2 2
MIRT648385 ZNF22 zinc finger protein 22 2 2
MIRT648629 LEMD2 LEM domain containing 2 2 2
MIRT649353 SLC27A2 solute carrier family 27 member 2 2 2
MIRT649395 SH2D4A SH2 domain containing 4A 2 2
MIRT650241 CD68 CD68 molecule 2 2
MIRT650379 PTGIS prostaglandin I2 synthase 2 2
MIRT650705 KRT32 keratin 32 2 2
MIRT650854 UNC13D unc-13 homolog D 2 2
MIRT651042 ZNF644 zinc finger protein 644 2 2
MIRT651102 ZNF48 zinc finger protein 48 2 2
MIRT651130 ZNF398 zinc finger protein 398 2 2
MIRT652089 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT652200 TRIM33 tripartite motif containing 33 2 2
MIRT652422 TMEM239 transmembrane protein 239 2 2
MIRT652755 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653201 SP9 Sp9 transcription factor 2 2
MIRT653338 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653715 SLC25A32 solute carrier family 25 member 32 2 2
MIRT654456 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT654499 RABIF RAB interacting factor 2 2
MIRT654678 PSMB5 proteasome subunit beta 5 2 2
MIRT655162 PHF20L1 PHD finger protein 20 like 1 2 2
MIRT655540 PADI2 peptidyl arginine deiminase 2 2 4
MIRT655850 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT656248 MEX3A mex-3 RNA binding family member A 2 2
MIRT656581 LSAMP limbic system-associated membrane protein 2 2
MIRT657597 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT657824 GJD3 gap junction protein delta 3 2 2
MIRT658466 FAM102B family with sequence similarity 102 member B 2 2
MIRT659083 DENR density regulated re-initiation and release factor 2 2
MIRT659196 CYBB cytochrome b-245 beta chain 2 2
MIRT659558 CGGBP1 CGG triplet repeat binding protein 1 2 2
MIRT659860 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660172 BNC2 basonuclin 2 2 2
MIRT660626 ANKRD52 ankyrin repeat domain 52 2 2
MIRT660917 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT660979 ABHD2 abhydrolase domain containing 2 2 2
MIRT661564 EPHX2 epoxide hydrolase 2 2 2
MIRT662214 CCRL2 C-C motif chemokine receptor like 2 2 2
MIRT662246 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT662560 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT662591 MAGEB4 MAGE family member B4 2 2
MIRT663294 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT663437 FBXO2 F-box protein 2 2 2
MIRT663811 RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2 2
MIRT663821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT665959 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT666115 SRRM4 serine/arginine repetitive matrix 4 2 2
MIRT667448 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT669330 BSND barttin CLCNK type accessory beta subunit 2 2
MIRT669409 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669641 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT672663 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT673266 RUNDC1 RUN domain containing 1 2 2
MIRT676995 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT679290 SSBP2 single stranded DNA binding protein 2 2 2
MIRT687508 NCKAP1 NCK associated protein 1 2 2
MIRT698932 SPATA2 spermatogenesis associated 2 2 2
MIRT700852 PERP PERP, TP53 apoptosis effector 2 2
MIRT702426 KIAA1958 KIAA1958 2 2
MIRT703939 EPB41L1 erythrocyte membrane protein band 4.1 like 1 2 2
MIRT708962 SLC12A3 solute carrier family 12 member 3 2 2
MIRT709742 UBD ubiquitin D 2 2
MIRT709946 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711121 CYYR1 cysteine and tyrosine rich 1 2 2
MIRT711217 RETSAT retinol saturase 2 2
MIRT711576 ASPA aspartoacylase 2 2
MIRT711599 LHX5 LIM homeobox 5 2 2
MIRT712232 RCC2 regulator of chromosome condensation 2 2 2
MIRT713317 TMEM44 transmembrane protein 44 2 2
MIRT713510 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT713543 GJB1 gap junction protein beta 1 2 2
MIRT713621 MED8 mediator complex subunit 8 2 2
MIRT714988 TSPAN11 tetraspanin 11 2 2
MIRT715449 PTCD1 pentatricopeptide repeat domain 1 2 2
MIRT715575 ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough 2 2
MIRT715771 DDX42 DEAD-box helicase 42 2 2
MIRT715887 GNG2 G protein subunit gamma 2 2 2
MIRT716091 HARS histidyl-tRNA synthetase 2 2
MIRT717403 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT717965 PXMP4 peroxisomal membrane protein 4 2 2
MIRT718324 METTL7A methyltransferase like 7A 2 2
MIRT718628 DIP2A disco interacting protein 2 homolog A 2 2
MIRT719213 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719234 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719817 LRRC4 leucine rich repeat containing 4 2 2
MIRT719978 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720480 TMEM178B transmembrane protein 178B 2 2
MIRT720713 RAPGEF6 Rap guanine nucleotide exchange factor 6 2 2
MIRT721006 ZNF619 zinc finger protein 619 2 2
MIRT721741 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT723547 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT723596 FKRP fukutin related protein