miRTarBase - #MIRT489630


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pre-miRNA Information
pre-miRNA hsa-mir-1973   
Genomic Coordinates chr4: 116299725 - 116299768
Synonyms hsa-mir-1973, MIR1973
Description Homo sapiens miR-1973 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1973
Sequence 26| ACCGUGCAAAGGUAGCAUA |44
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ALS2CL   
Synonyms RN49018
Description ALS2 C-terminal like
Transcript NM_001190707   
Other Transcripts NM_147129   
Expression
Putative miRNA Targets on ALS2CL
3'UTR of ALS2CL
(miRNA target sites are highlighted)		 
>ALS2CL|NM_001190707|3'UTR
   1 CCTGGCCTTTCCTGGACAGACTGAAGAGCTGAGCAGGGCACTGCCAGCCTGTCCCTCATTACCCAAGGCAAGGGGCAGGA
  81 CAGGCCCTCAGAAGCAGCTCTTGGAGGAGATGAGCATTTTGTTTTGCACAGGAAGATGCTGCTGCTGCCCTGACTGGGAT
 161 GAGGGTGAGGGGTGACGGGTGTGGCCCTGGATGTGGTGGTTTTCCCTTGGCCACTAGCCCATCTTCAATGACCCCTTAAT
 241 CTGCAGCAGCTCACAGGCTGGGGGTGAGGAGTCCCTGGCTTCTCTTAGCCTGAGCCTTTCTCCCAAGTTCCAGAGCCTCT
 321 CCGGGCCTCAGTGCTGCCATCTGTACAATGGTGGAGTGAGTACGCTGTAAAGGACCTTCCATTCATTTTGCTGAATTCCA
 401 GAGTCCTTTTGGAAAACTGACTTTAGTCTGCTGGGCTGTATTGACCTCTGGCAGGCTCGAAGCCTCACTGGGTATGCAGT
 481 CAACAGGATGGGCCTGGAGATCCGTGAACTGCAGGCCACGTACCCATGACGTAAACGGCGGCACTGGAGCAAGCTGGGGC
 561 GGGGGGTGGGTAAACCCTCACTGCCAGCAGGCCCCAAGTGGCTTGTAAATCATTCTCCTGTGATGTCTGTGGGCCTGCGT
 641 GGGGACAACAGGGGCACATGACATCTGCCTGGGCCCTGACCAATAAACCCTCAGACCCAGGACCCAGGACCCTGCTGTAG
 721 TTGGGGAGCAGGAGTACCTTTGGGAGGGGAGGACTTTATTTAAACAGTGGTTCTAGTGTGGGACCAAGAGAGGCAGGAGC
 801 TGGGTCTTGGGGCAGCTTTATTCCTGTTGGGCCTCAGTTTCTCTTCCCCACACAGTTTATCTTCCGTCACATTGTGCCGG
 881 GTGACGTGCACGGTCTCCCTCTGCCCTAGCCGGAGATGCATGATGACAGGCAGTGTGATGTGTTCTGAAAGTGTCCAGGG
 961 CAAAGCGTAGGGAGAGGGTGGATTTGTGCAGGGTGCAGCTCTGGAGAAGAAGCTGGATCACTCTTGGTCCCATTCCCTAG
1041 GCCCTGAGCAAGTCAGGCTCCTGGCTCTGGGTGTGGCTCCCCCAAACGAAGTACTGACTTCAGCCTGTGAGGGGAGGGTT
1121 GAGGGAGGCTCTGGAAAGCCCAGCCACACCTGAGTCCCTGGCAGTAGCCTTGGGGCAGAGGGCACCCGCAGAGTCCCAGA
1201 GATGATGTGGGCAGTGGGCAGAGAGAGCCTTGGCGCCTCTGTTTGCCACCACTTCCCCAGGAAGGAGGGACAGCATTTCT
1281 CTGGCTGGTTCCACTAAATGTGCCAGCCCAAATGCAGGGCATGGGCTCTGGTTCTGCCAGGAGCCTGTGACACCCCCAGG
1361 AAGGGGGTGGAACTGAGGAAGAGCGAGGATATGCAGGCACTCATGCTTACCGGGACTGGGGCAGCTCACTAGGATTCTAT
1441 CCTTTCCAATCGGCATCAGCCAGCTCTTGTCCCCTGATAAGTGAGGACAGCCTGACCCTGGCCTCAAATGCAGCCATCCC
1521 TGAGTTCATGCGATGCTGACGGGACCCCAGCACACTTCCCTGCCTCCTTTGAGATCTGCGAGCCCTTGCTGCAGTTCAGA
1601 TTCAACAAGGCCCTCTGCCCACCCTCTCACTAGGCCTCACCCAACACCAGTGGAACTGGAGCCTCTGGCTGGGCACAGTG
1681 GCTCACTTTGGGAGGCTGAGGCAGGAAGGCTGCTGGAAACTGAGAGTTCAAGACCAGCCTGGGCAACATAGTGAGACCCT
1761 GTCTCTACAAATACAAAATAAAATAATTAGCTGGGTGTGTTGGTGTGTGCCTGTGGTCCCAGCTACTCGGGAGGCTGAGG
1841 TGGGAAGATCCCTGAGCCTGGAGGGTCGAGGTTGCAGTGAGCGGAGATCGCACCTCTGCACTCAATCCTGGGTGACAAAA
1921 TGAAACCCTGCCTCAAAAATAAAAATAAAAATAAAAATAAAATAAATAAAAAAGAGCATCTGGACAGAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auacgauggaaACGUGCCa 5'
                     ||||||| 
Target 5' gccgggtgacgTGCACGGt 3'
 876 - 894 140.00 -14.30
2 
miRNA  3' auACGAUGGAAACGUGCCa 5'
            | :|: :||||||| | 
Target 5' caTTTTG-TTTTGCACAGg 3'
 115 - 132 120.00 -11.30
3 
miRNA  3' auaCGAUGGAAACGUGcca 5'
             || |||| |||||   
Target 5' atcGC-ACCTCTGCACtca 3'
 1887 - 1904 119.00 -10.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497734 33 COSMIC
COSN30100737 46 COSMIC
COSN30152910 57 COSMIC
COSN32062606 80 COSMIC
COSN31778316 323 COSMIC
COSN35116 884 COSMIC
COSN32057635 911 COSMIC
COSN6769034 1023 COSMIC
COSN26234047 1030 COSMIC
COSN29132173 1164 COSMIC
COSN28201469 1169 COSMIC
COSN32173553 1704 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780782567 2 dbSNP
rs1330157864 5 dbSNP
rs768652836 7 dbSNP
rs747006949 10 dbSNP
rs1374191316 12 dbSNP
rs189148441 13 dbSNP
rs1424715473 20 dbSNP
rs757945773 23 dbSNP
rs1156440627 25 dbSNP
rs763928849 33 dbSNP
rs1226495305 34 dbSNP
rs749916076 35 dbSNP
rs1031191078 37 dbSNP
rs758079880 38 dbSNP
rs1479388916 40 dbSNP
rs756823469 45 dbSNP
rs1205305860 46 dbSNP
rs565999255 48 dbSNP
rs755744810 50 dbSNP
rs1026802187 57 dbSNP
rs1396659586 65 dbSNP
rs1456593467 68 dbSNP
rs1185681688 75 dbSNP
rs184390150 76 dbSNP
rs995038852 89 dbSNP
rs1180565862 94 dbSNP
rs1423458770 101 dbSNP
rs899345291 105 dbSNP
rs1012168988 121 dbSNP
rs532598902 125 dbSNP
rs565258302 126 dbSNP
rs1397557775 129 dbSNP
rs1017755272 130 dbSNP
rs888462966 137 dbSNP
rs1007824476 171 dbSNP
rs528416242 176 dbSNP
rs1358293769 177 dbSNP
rs1445558283 185 dbSNP
rs776606672 185 dbSNP
rs192093319 191 dbSNP
rs998921488 193 dbSNP
rs1040917147 211 dbSNP
rs1363630093 215 dbSNP
rs902962450 226 dbSNP
rs1043181845 228 dbSNP
rs532011356 236 dbSNP
rs748854273 244 dbSNP
rs561554867 245 dbSNP
rs1442121543 247 dbSNP
rs1208451843 260 dbSNP
rs938638790 262 dbSNP
rs889503014 263 dbSNP
rs777115725 269 dbSNP
rs1486464463 271 dbSNP
rs111751718 278 dbSNP
rs1193598045 279 dbSNP
rs1420783675 281 dbSNP
rs928546792 283 dbSNP
rs1481134079 289 dbSNP
rs755609955 322 dbSNP
rs1424011648 339 dbSNP
rs950756213 341 dbSNP
rs1320021172 351 dbSNP
rs542809971 356 dbSNP
rs1289498366 358 dbSNP
rs947006914 360 dbSNP
rs369238932 363 dbSNP
rs113245918 364 dbSNP
rs1344540259 370 dbSNP
rs1356759016 375 dbSNP
rs545064803 400 dbSNP
rs752595591 403 dbSNP
rs963425224 405 dbSNP
rs1017791152 406 dbSNP
rs577250101 407 dbSNP
rs924103560 409 dbSNP
rs555703248 428 dbSNP
rs548133077 430 dbSNP
rs1216438812 433 dbSNP
rs188002432 434 dbSNP
rs1288604045 435 dbSNP
rs1199503462 438 dbSNP
rs1403789701 439 dbSNP
rs1245675009 441 dbSNP
rs1363250297 443 dbSNP
rs781122264 450 dbSNP
rs1476810639 455 dbSNP
rs954977565 456 dbSNP
rs559211982 458 dbSNP
rs754769205 459 dbSNP
rs1156677692 467 dbSNP
rs1367367693 471 dbSNP
rs1406513188 474 dbSNP
rs1384907527 477 dbSNP
rs555546222 488 dbSNP
rs1324255239 498 dbSNP
rs1157121835 503 dbSNP
rs1455682484 504 dbSNP
rs971312426 506 dbSNP
rs533786852 511 dbSNP
rs1023647226 517 dbSNP
rs566657883 519 dbSNP
rs185669632 520 dbSNP
rs1042700684 530 dbSNP
rs1011743098 531 dbSNP
rs1449382760 536 dbSNP
rs371518703 536 dbSNP
rs1233090209 537 dbSNP
rs994036332 539 dbSNP
rs111523463 540 dbSNP
rs75741978 559 dbSNP
rs1283482427 560 dbSNP
rs571684322 561 dbSNP
rs554205740 562 dbSNP
rs1377922100 565 dbSNP
rs1352649642 567 dbSNP
rs1446371643 567 dbSNP
rs73831184 571 dbSNP
rs1246085418 575 dbSNP
rs1049482144 579 dbSNP
rs1222569771 580 dbSNP
rs1343075360 591 dbSNP
rs1258193451 592 dbSNP
rs1457020592 595 dbSNP
rs1196389902 598 dbSNP
rs1047438706 599 dbSNP
rs1244702026 600 dbSNP
rs947142668 601 dbSNP
rs550173306 602 dbSNP
rs1366631115 606 dbSNP
rs532050382 613 dbSNP
rs1476389543 618 dbSNP
rs919258040 622 dbSNP
rs3210183 624 dbSNP
rs934323842 625 dbSNP
rs1389891656 629 dbSNP
rs141719804 638 dbSNP
rs910634387 639 dbSNP
rs986329190 649 dbSNP
rs949558602 652 dbSNP
rs916772893 653 dbSNP
rs1339199668 654 dbSNP
rs759729308 655 dbSNP
rs954841854 656 dbSNP
rs952833229 657 dbSNP
rs1216335161 660 dbSNP
rs11711100 667 dbSNP
rs1483405463 668 dbSNP
rs138128338 680 dbSNP
rs999527037 688 dbSNP
rs1475133875 690 dbSNP
rs1199656443 694 dbSNP
rs967623119 702 dbSNP
rs77957046 703 dbSNP
rs192476211 706 dbSNP
rs894258017 716 dbSNP
rs1034042952 729 dbSNP
rs1424341242 733 dbSNP
rs1477545597 738 dbSNP
rs1168694389 741 dbSNP
rs764114223 743 dbSNP
rs1466784552 746 dbSNP
rs907057302 751 dbSNP
rs1302617642 752 dbSNP
rs776275083 753 dbSNP
rs1400539512 759 dbSNP
rs1046858105 760 dbSNP
rs544716689 762 dbSNP
rs1384375748 765 dbSNP
rs1299345577 782 dbSNP
rs1339200531 792 dbSNP
rs1397574848 794 dbSNP
rs1248469426 798 dbSNP
rs1284721437 800 dbSNP
rs929887582 813 dbSNP
rs898410821 815 dbSNP
rs577289561 850 dbSNP
rs562147863 854 dbSNP
rs1253984953 859 dbSNP
rs187693520 865 dbSNP
rs145514957 866 dbSNP
rs775875333 871 dbSNP
rs1487307728 878 dbSNP
rs1011321789 879 dbSNP
rs555423173 880 dbSNP
rs534073240 881 dbSNP
rs986233176 885 dbSNP
rs112983161 886 dbSNP
rs557901389 891 dbSNP
rs977613993 892 dbSNP
rs968067151 901 dbSNP
rs1021863842 905 dbSNP
rs11711074 911 dbSNP
rs1304407006 914 dbSNP
rs958381174 917 dbSNP
rs906882585 921 dbSNP
rs1385809783 924 dbSNP
rs1046626678 928 dbSNP
rs1337223936 931 dbSNP
rs1240599176 934 dbSNP
rs1285097458 944 dbSNP
rs949699674 952 dbSNP
rs1335172623 960 dbSNP
rs571726467 966 dbSNP
rs3827495 967 dbSNP
rs1190767303 976 dbSNP
rs183097823 981 dbSNP
rs1451203700 989 dbSNP
rs567626610 990 dbSNP
rs370359258 993 dbSNP
rs1380128329 995 dbSNP
rs1219160209 1010 dbSNP
rs770745524 1014 dbSNP
rs1182687077 1025 dbSNP
rs994009425 1035 dbSNP
rs1167535107 1036 dbSNP
rs558917381 1041 dbSNP
rs771783485 1057 dbSNP
rs374233292 1059 dbSNP
rs866890676 1071 dbSNP
rs1374431129 1076 dbSNP
rs1247990906 1077 dbSNP
rs1313357213 1079 dbSNP
rs961378511 1083 dbSNP
rs912576949 1085 dbSNP
rs942570836 1087 dbSNP
rs889134485 1088 dbSNP
rs1237911359 1097 dbSNP
rs1270211440 1112 dbSNP
rs1184021507 1117 dbSNP
rs189975178 1119 dbSNP
rs1423787438 1125 dbSNP
rs1028247636 1131 dbSNP
rs933395064 1133 dbSNP
rs748251693 1135 dbSNP
rs769197225 1139 dbSNP
rs957205317 1139 dbSNP
rs1449934466 1141 dbSNP
rs1031396607 1142 dbSNP
rs923371304 1147 dbSNP
rs978020212 1148 dbSNP
rs999037601 1150 dbSNP
rs1320134059 1151 dbSNP
rs946217519 1154 dbSNP
rs1244221086 1155 dbSNP
rs1257649733 1158 dbSNP
rs3747520 1174 dbSNP
rs990373371 1187 dbSNP
rs895360492 1188 dbSNP
rs1055310700 1201 dbSNP
rs781056309 1218 dbSNP
rs1033977381 1223 dbSNP
rs140403227 1227 dbSNP
rs1330934472 1232 dbSNP
rs971590440 1234 dbSNP
rs532873158 1235 dbSNP
rs1176489809 1241 dbSNP
rs138542200 1254 dbSNP
rs186951475 1255 dbSNP
rs1445676820 1256 dbSNP
rs1299967375 1262 dbSNP
rs1341119607 1273 dbSNP
rs1400688547 1274 dbSNP
rs1277692623 1298 dbSNP
rs367973827 1300 dbSNP
rs1442509350 1308 dbSNP
rs201704487 1317 dbSNP
rs1182256065 1330 dbSNP
rs1016748573 1338 dbSNP
rs3747519 1339 dbSNP
rs386660748 1340 dbSNP
rs1206609068 1343 dbSNP
rs878880259 1343 dbSNP
rs529597993 1345 dbSNP
rs1488939825 1353 dbSNP
rs143019930 1364 dbSNP
rs1220958568 1366 dbSNP
rs1260473957 1381 dbSNP
rs1478777852 1383 dbSNP
rs573065052 1384 dbSNP
rs1050450321 1385 dbSNP
rs754033627 1390 dbSNP
rs1160308615 1393 dbSNP
rs1223615828 1395 dbSNP
rs1031952587 1409 dbSNP
rs557989945 1411 dbSNP
rs1324797339 1412 dbSNP
rs867342510 1420 dbSNP
rs1438798420 1421 dbSNP
rs1345008922 1424 dbSNP
rs901947667 1428 dbSNP
rs1275681251 1432 dbSNP
rs557594141 1433 dbSNP
rs1232543790 1438 dbSNP
rs1288649738 1439 dbSNP
rs1355019639 1441 dbSNP
rs545983088 1442 dbSNP
rs756155118 1449 dbSNP
rs575502091 1451 dbSNP
rs946092571 1452 dbSNP
rs914751512 1462 dbSNP
rs1165134628 1466 dbSNP
rs1054512846 1471 dbSNP
rs1399910018 1483 dbSNP
rs995738618 1487 dbSNP
rs937632784 1488 dbSNP
rs1156784368 1491 dbSNP
rs927544383 1492 dbSNP
rs898650728 1496 dbSNP
rs981103561 1499 dbSNP
rs1037638792 1500 dbSNP
rs971071491 1528 dbSNP
rs752819042 1531 dbSNP
rs972523370 1532 dbSNP
rs79266337 1540 dbSNP
rs1016780700 1546 dbSNP
rs1239970641 1551 dbSNP
rs891171367 1554 dbSNP
rs1359157876 1558 dbSNP
rs1209881733 1563 dbSNP
rs1051203483 1568 dbSNP
rs1006726926 1578 dbSNP
rs1315569292 1579 dbSNP
rs953971335 1580 dbSNP
rs764592814 1607 dbSNP
rs1029566299 1611 dbSNP
rs998486455 1613 dbSNP
rs538324327 1618 dbSNP
rs990055647 1622 dbSNP
rs901855804 1626 dbSNP
rs1473106181 1628 dbSNP
rs1281408014 1635 dbSNP
rs1388597136 1636 dbSNP
rs567566059 1638 dbSNP
rs1042074012 1639 dbSNP
rs1333623679 1641 dbSNP
rs1173616384 1647 dbSNP
rs1401408966 1659 dbSNP
rs768186268 1660 dbSNP
rs1010321920 1668 dbSNP
rs1294102704 1679 dbSNP
rs1446492157 1681 dbSNP
rs1429764094 1686 dbSNP
rs1342759356 1694 dbSNP
rs62246180 1704 dbSNP
rs149064051 1705 dbSNP
rs11540631 1709 dbSNP
rs1054588421 1712 dbSNP
rs1283044390 1715 dbSNP
rs1332034060 1716 dbSNP
rs1220025984 1720 dbSNP
rs971261310 1735 dbSNP
rs937498965 1751 dbSNP
rs555702203 1753 dbSNP
rs1173551349 1755 dbSNP
rs1420197906 1766 dbSNP
rs1186792468 1768 dbSNP
rs1980247 1774 dbSNP
rs150037049 1787 dbSNP
rs1172986024 1792 dbSNP
rs1424566211 1800 dbSNP
rs991214589 1805 dbSNP
rs1166465215 1810 dbSNP
rs1404837014 1815 dbSNP
rs1397050335 1824 dbSNP
rs1334096237 1826 dbSNP
rs1485082894 1828 dbSNP
rs950319475 1829 dbSNP
rs1224819894 1836 dbSNP
rs766871580 1840 dbSNP
rs1250234210 1841 dbSNP
rs1209780891 1846 dbSNP
rs551647422 1858 dbSNP
rs533393547 1861 dbSNP
rs972771163 1863 dbSNP
rs569087972 1867 dbSNP
rs375667562 1868 dbSNP
rs1312916865 1874 dbSNP
rs995707547 1875 dbSNP
rs1264023496 1877 dbSNP
rs1428098797 1879 dbSNP
rs772740325 1882 dbSNP
rs182993088 1883 dbSNP
rs1466859260 1884 dbSNP
rs1029473041 1889 dbSNP
rs976701929 1890 dbSNP
rs1015848886 1894 dbSNP
rs1004761596 1898 dbSNP
rs1339317016 1908 dbSNP
rs966987847 1918 dbSNP
rs1380104836 1921 dbSNP
rs571733962 1922 dbSNP
rs140530089 1926 dbSNP
rs1232254606 1951 dbSNP
rs190498068 1954 dbSNP
rs1377744820 1955 dbSNP
rs893252673 1958 dbSNP
rs899828890 1959 dbSNP
rs1054502192 1963 dbSNP
rs1193381095 1963 dbSNP
rs1203527231 1963 dbSNP
rs936020354 1967 dbSNP
rs1442048832 1971 dbSNP
rs1392569505 1974 dbSNP
rs1033040753 1976 dbSNP
rs1450981398 1979 dbSNP
rs1001552614 1989 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auacgauggaaACGUGCCa 5'
                     ||||||| 
Target 5' ---------cgUGCACGGu 3'
 		1 - 10
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000318962.4 | 3UTR | CGUGCACGGUCUCCCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
5 hsa-miR-1973 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT124152 GINS4 GINS complex subunit 4 2 4
MIRT489630 ALS2CL ALS2 C-terminal like 2 2
MIRT492236 SLC48A1 solute carrier family 48 member 1 2 2
MIRT566716 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT722042 SSH3 slingshot protein phosphatase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-1973 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 up-regulated
miR-1973 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1973 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-1973 Paclitaxel 36314 NSC125973 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-1973 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (COC1)
hsa-miR-1973 Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-1973 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1973 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1973 Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-1973 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-1973 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-1973 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1973 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1973 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-1973 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-1973 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-1973 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1973 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-1973 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-1973 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1973 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-1973 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1973 Gemcitabine 60750 NSC613327 approved sensitive cell line (HuH28)
hsa-miR-1973 Platinum 23939 resistant tissue
hsa-miR-1973 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-1973 Bortezomib 387447 NSC681239 approved resistant tissue (multiple myeloma)
hsa-miR-1973 Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-1973 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-1973 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-1973 Cetuximab resistant tissue (colorectal carcinoma)
hsa-miR-1973 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1973 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)
hsa-miR-1973 Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)

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