pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-5p
Sequence 6| UUGUGUGAGUACAGAGAGCAUC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs763248242 2 dbSNP
rs186621048 3 dbSNP
rs1455267770 12 dbSNP
rs1170462641 19 dbSNP
rs1435853423 22 dbSNP
Putative Targets

Gene Information
Gene Symbol TERF2IP   
Synonyms DRIP5, RAP1
Description TERF2 interacting protein
Transcript NM_018975   
Expression
Putative miRNA Targets on TERF2IP
3'UTR of TERF2IP
(miRNA target sites are highlighted)
>TERF2IP|NM_018975|3'UTR
   1 TTGGCAAGATAATGAGAAAAGAAAAAAGTCATGGTAGGTGAGGTGGTTAAAAAAAATTGTGACCAATGAACTTTAGAGAG
  81 TTCTTGCATTGGAACTGGCACTTATTTTCTGACCATCGCTGCTGTTGCTCTGTGAGTCCTAGATTTTTGTAGCCAAGCAG
 161 AGTTGTAGAGGGGGATAAAAAGAAAAGAAATTGGATGTATTTACAGCTGTCCTTGAACAAGTATCAATGTGTTTATGAAA
 241 GGAAGATCTAAATCAGACAGGAGTTGGTCTACATAGTAGTAATCCATTGTTGGAATGGAACCCTTGCTATAGTAGTGACA
 321 AAGTGAAAGGAAATTTAGGAGGCATAGGCCATTTCAGGCAGCATAAGTAATCTCCTGTCCTTTGGCAGAAGCTCCTTTAG
 401 ATTGGGATAGATTCCAAATAAAGAATCTAGAAATAGGAGAAGATTTAATTATGAGGCCTTGAACACGGATTATCCCCAAA
 481 CCCTTGTCATTTCCCCCAGTGAGCTCTGATTTCTAGACTGCTTTGAAAATGCTGTATTCATTTTGCTAACTTAGTATTTG
 561 GGTACCCTGCTCTTTGGCTGTTCTTTTTTTGGAGCCCTTCTCAGTCAAGTCTGCCGGATGTCTTTCTTTACCTACCCCTC
 641 AGTTTTCCTTAAAACGCGCACACAACTCTAGAGAGTGTTAAGAATAATGTTACTTGGTTAATGTGTTATTTATTGAGTAT
 721 TGTTTGTGCTAAGCATTGTGTTAGATTTAAAAAATTAGTGGATTGACTCCACTTTGTTGTGTTGTTTTCATTGTTGAAAA
 801 TAAATATAACTTTGTATTCGAGTCTCGTCAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuaCGAGAGACAU-----GAGUGUGUu 5'
             |:|:||  ||     | |||||| 
Target 5' tcaGTTTTCCTTAAAACGCGCACACAa 3'
639 - 665 123.00 -11.80
2
miRNA  3' cuacgagAGACAUGAGUGUGUu 5'
                 |||  | ||| ||| 
Target 5' aggaagaTCT-AAATCAGACAg 3'
240 - 260 114.00 -7.30
3
miRNA  3' cuacgagagACAUGAGUGUguu 5'
                   ||||:|:|||   
Target 5' gaaattggaTGTATTTACAgct 3'
187 - 208 105.00 -8.52
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN21192725 2 COSMIC
COSN26998300 40 COSMIC
COSN30118944 45 COSMIC
COSN31492689 88 COSMIC
COSN31525514 188 COSMIC
COSN18937796 219 COSMIC
COSN31961239 352 COSMIC
COSN5411838 541 COSMIC
COSN22508891 633 COSMIC
COSN7271605 735 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs145177251 1 dbSNP
rs199596670 4 dbSNP
rs780194201 6 dbSNP
rs1206080215 9 dbSNP
rs1264384699 11 dbSNP
rs1445747342 14 dbSNP
rs1193160740 15 dbSNP
rs1332389903 17 dbSNP
rs1419245237 17 dbSNP
rs751471311 19 dbSNP
rs770287626 21 dbSNP
rs773676067 22 dbSNP
rs543971435 23 dbSNP
rs779236005 24 dbSNP
rs748995836 27 dbSNP
rs1034228721 28 dbSNP
rs770470672 29 dbSNP
rs748639482 30 dbSNP
rs1313370565 31 dbSNP
rs772636447 32 dbSNP
rs773702576 33 dbSNP
rs1291578439 34 dbSNP
rs377354294 37 dbSNP
rs1174441055 42 dbSNP
rs188012863 43 dbSNP
rs1262844441 47 dbSNP
rs758952216 49 dbSNP
rs773954934 49 dbSNP
rs576255798 50 dbSNP
rs1186437425 55 dbSNP
rs1447174424 57 dbSNP
rs765521113 58 dbSNP
rs1006031220 65 dbSNP
rs1014705158 72 dbSNP
rs542027587 76 dbSNP
rs1275238722 85 dbSNP
rs192591533 88 dbSNP
rs549970644 91 dbSNP
rs1226131041 106 dbSNP
rs572338846 111 dbSNP
rs976187065 118 dbSNP
rs183658113 119 dbSNP
rs1221239711 120 dbSNP
rs879589505 122 dbSNP
rs1287367818 125 dbSNP
rs372525429 133 dbSNP
rs532775987 136 dbSNP
rs549419958 137 dbSNP
rs1360074460 140 dbSNP
rs187619079 141 dbSNP
rs1428405171 143 dbSNP
rs1392526061 147 dbSNP
rs1188643005 150 dbSNP
rs1422669566 173 dbSNP
rs1224152474 179 dbSNP
rs867192703 180 dbSNP
rs1253715830 184 dbSNP
rs985692625 188 dbSNP
rs779983053 193 dbSNP
rs1483478134 207 dbSNP
rs1250529130 219 dbSNP
rs1247687680 226 dbSNP
rs375856547 228 dbSNP
rs911444238 235 dbSNP
rs1275186411 249 dbSNP
rs1229299383 253 dbSNP
rs1339939031 258 dbSNP
rs1310892372 259 dbSNP
rs1397979603 264 dbSNP
rs192816216 267 dbSNP
rs549589398 271 dbSNP
rs752676443 273 dbSNP
rs936203515 274 dbSNP
rs1372960031 278 dbSNP
rs1054536010 281 dbSNP
rs1366170928 291 dbSNP
rs1457031037 291 dbSNP
rs1392063053 302 dbSNP
rs1450240104 307 dbSNP
rs566223137 308 dbSNP
rs913348813 311 dbSNP
rs1424056917 312 dbSNP
rs1250568013 313 dbSNP
rs946147122 315 dbSNP
rs578014885 336 dbSNP
rs1252531144 344 dbSNP
rs1209131172 345 dbSNP
rs1355786998 346 dbSNP
rs150763950 348 dbSNP
rs879943448 349 dbSNP
rs1322559001 356 dbSNP
rs1407303456 359 dbSNP
rs1287898411 364 dbSNP
rs1408445444 366 dbSNP
rs1352710857 375 dbSNP
rs138025937 376 dbSNP
rs887674420 378 dbSNP
rs1432781800 380 dbSNP
rs1294809675 386 dbSNP
rs1457914066 387 dbSNP
rs1006096793 388 dbSNP
rs1473472114 390 dbSNP
rs962152795 391 dbSNP
rs1212239177 395 dbSNP
rs111634375 398 dbSNP
rs1468953987 398 dbSNP
rs953084634 407 dbSNP
rs1226766299 420 dbSNP
rs985746290 425 dbSNP
rs1018506661 428 dbSNP
rs1281927363 435 dbSNP
rs1357976057 436 dbSNP
rs777899475 437 dbSNP
rs1329865512 438 dbSNP
rs1469342372 443 dbSNP
rs1303982518 448 dbSNP
rs990314539 451 dbSNP
rs913411368 458 dbSNP
rs1318186565 467 dbSNP
rs142824586 468 dbSNP
rs11556641 469 dbSNP
rs1171786358 474 dbSNP
rs574093286 475 dbSNP
rs1379356261 477 dbSNP
rs146103190 485 dbSNP
rs1454797138 486 dbSNP
rs928683364 492 dbSNP
rs555564686 496 dbSNP
rs1466446449 498 dbSNP
rs1285141634 502 dbSNP
rs752453772 504 dbSNP
rs140021449 505 dbSNP
rs1343301880 516 dbSNP
rs1186850661 525 dbSNP
rs770572609 528 dbSNP
rs1365039197 544 dbSNP
rs1294805820 548 dbSNP
rs937355335 560 dbSNP
rs1365487273 561 dbSNP
rs1333079340 568 dbSNP
rs1412609536 571 dbSNP
rs1055800278 572 dbSNP
rs375108390 583 dbSNP
rs887726588 586 dbSNP
rs941932027 588 dbSNP
rs199546803 592 dbSNP
rs1473870414 595 dbSNP
rs10308 601 dbSNP
rs1036650151 609 dbSNP
rs778631144 615 dbSNP
rs541279404 616 dbSNP
rs184950115 617 dbSNP
rs866605736 618 dbSNP
rs1441093318 624 dbSNP
rs1455506721 629 dbSNP
rs372904811 633 dbSNP
rs771670823 634 dbSNP
rs777562523 635 dbSNP
rs888848237 635 dbSNP
rs1161117356 636 dbSNP
rs577191710 641 dbSNP
rs749266007 641 dbSNP
rs774840803 642 dbSNP
rs1395416475 645 dbSNP
rs543031949 649 dbSNP
rs190202248 654 dbSNP
rs563030981 656 dbSNP
rs377037876 657 dbSNP
rs957668474 658 dbSNP
rs990367014 659 dbSNP
rs1020933771 660 dbSNP
rs1170402723 661 dbSNP
rs967587215 664 dbSNP
rs1278656398 666 dbSNP
rs769322263 668 dbSNP
rs1471948625 671 dbSNP
rs549310785 675 dbSNP
rs1189108633 676 dbSNP
rs1482925124 679 dbSNP
rs1250333165 683 dbSNP
rs982005457 684 dbSNP
rs559934676 685 dbSNP
rs1226883904 688 dbSNP
rs1270428868 690 dbSNP
rs1330381677 694 dbSNP
rs1226081488 698 dbSNP
rs779084742 706 dbSNP
rs1276563721 711 dbSNP
rs777230788 723 dbSNP
rs1444239322 726 dbSNP
rs1348395750 727 dbSNP
rs1309825070 730 dbSNP
rs1188505149 738 dbSNP
rs1442860314 738 dbSNP
rs149357328 739 dbSNP
rs369498526 740 dbSNP
rs571132688 744 dbSNP
rs1416300730 746 dbSNP
rs1184028449 749 dbSNP
rs1165917607 762 dbSNP
rs1472491492 768 dbSNP
rs937399320 769 dbSNP
rs1412462103 772 dbSNP
rs991535394 773 dbSNP
rs762284491 778 dbSNP
rs1246570599 780 dbSNP
rs1218760518 782 dbSNP
rs1452825154 786 dbSNP
rs549562926 788 dbSNP
rs1207683483 791 dbSNP
rs1326878774 792 dbSNP
rs1290014898 794 dbSNP
rs1224062887 799 dbSNP
rs1366832555 799 dbSNP
rs1272987719 811 dbSNP
rs1465461171 820 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 54386.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuacgagagacaugaGUGUGUu 5'
                         |||||| 
Target 5' uuuccuuaaaacgcgCACACAa 3'
1 - 22
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuacgagagacaugaGUGUGUu 5'
                         |||||| 
Target 5' uuuccuuaaaacgcgCACACAa 3'
2 - 23
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177604. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_6 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177628. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_6 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000300086.4 | 3UTR | UUUCCUUAAAACGCGCACACAACUCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000300086.4 | 3UTR | UUUUCCUUAAAACGCGCACACAACUCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000300086.4 | 3UTR | UUUUCCUUAAAACGCGCACACAACUCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
140 hsa-miR-6818-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071796 RNF11 ring finger protein 11 2 2
MIRT077120 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 4
MIRT079951 RNF138 ring finger protein 138 2 2
MIRT102968 EN2 engrailed homeobox 2 2 4
MIRT115694 MGRN1 mahogunin ring finger 1 2 2
MIRT121074 FGFRL1 fibroblast growth factor receptor like 1 2 2
MIRT143171 GLYR1 glyoxylate reductase 1 homolog 2 2
MIRT145635 LASP1 LIM and SH3 protein 1 2 2
MIRT282026 ARID3B AT-rich interaction domain 3B 2 6
MIRT301684 EP300 E1A binding protein p300 2 2
MIRT328627 AKIRIN1 akirin 1 2 2
MIRT340977 IPO5 importin 5 2 2
MIRT371401 STC2 stanniocalcin 2 2 2
MIRT378008 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT445185 CCDC88C coiled-coil domain containing 88C 2 2
MIRT447120 DUSP16 dual specificity phosphatase 16 2 2
MIRT449153 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT450200 ABHD15 abhydrolase domain containing 15 2 2
MIRT453853 ZNF12 zinc finger protein 12 2 2
MIRT459077 LSM1 LSM1 homolog, mRNA degradation associated 2 2
MIRT461304 MRPS27 mitochondrial ribosomal protein S27 2 2
MIRT464137 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT468114 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT471401 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT478220 DDX52 DExD-box helicase 52 2 2
MIRT479695 CCNT1 cyclin T1 2 2
MIRT479779 CCND1 cyclin D1 2 2
MIRT484980 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485016 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485034 TMEM189 transmembrane protein 189 2 8
MIRT485221 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490143 TERF2IP TERF2 interacting protein 2 6
MIRT508908 DOK6 docking protein 6 2 6
MIRT513877 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT515966 C9orf156 tRNA methyltransferase O 2 4
MIRT517892 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT518660 CLVS2 clavesin 2 2 4
MIRT520027 YOD1 YOD1 deubiquitinase 2 6
MIRT523884 EPHA5 EPH receptor A5 2 4
MIRT529237 PORCN porcupine O-acyltransferase 2 2
MIRT535337 PFN1 profilin 1 2 2
MIRT537532 EZR ezrin 2 2
MIRT537695 ELOVL6 ELOVL fatty acid elongase 6 2 2
MIRT538494 CLOCK clock circadian regulator 2 2
MIRT539140 ARHGAP35 Rho GTPase activating protein 35 2 2
MIRT541380 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT545018 PLP1 proteolipid protein 1 2 2
MIRT547732 KIF23 kinesin family member 23 2 4
MIRT548257 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT550372 MYLK3 myosin light chain kinase 3 2 2
MIRT551867 TMEM47 transmembrane protein 47 2 2
MIRT552289 SNAP29 synaptosome associated protein 29 2 2
MIRT552902 VSNL1 visinin like 1 2 8
MIRT552990 VAMP4 vesicle associated membrane protein 4 2 4
MIRT554729 RHOC ras homolog family member C 2 2
MIRT555301 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT556832 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT557523 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT558238 EDA2R ectodysplasin A2 receptor 2 2
MIRT558920 CBX1 chromobox 1 2 2
MIRT559198 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT559611 AMER1 APC membrane recruitment protein 1 2 2
MIRT559769 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT564648 ZNF487P zinc finger protein 487 1 1
MIRT565856 NHS NHS actin remodeling regulator 2 2
MIRT569044 ZNF655 zinc finger protein 655 2 2
MIRT569154 SIGMAR1 sigma non-opioid intracellular receptor 1 2 2
MIRT569166 DMD dystrophin 2 2
MIRT569205 CASZ1 castor zinc finger 1 2 2
MIRT569264 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT569431 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT569476 CTSE cathepsin E 2 2
MIRT570232 NCAN neurocan 2 2
MIRT570519 SHH sonic hedgehog 2 2
MIRT570680 FZD5 frizzled class receptor 5 2 2
MIRT572161 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT575142 Cd93 CD93 antigen 2 3
MIRT575644 Mitf microphthalmia-associated transcription factor 2 3
MIRT575653 Synpo synaptopodin 2 4
MIRT576375 Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2 2
MIRT576388 Fhl2 four and a half LIM domains 2 2 3
MIRT576413 Pla2g16 phospholipase A2, group XVI 2 2
MIRT576697 Hps3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 3
MIRT606872 CHST11 carbohydrate sulfotransferase 11 2 4
MIRT606940 GFRA1 GDNF family receptor alpha 1 2 6
MIRT607025 ZEB1 zinc finger E-box binding homeobox 1 2 2
MIRT607028 PPY pancreatic polypeptide 2 4
MIRT607081 MITF melanogenesis associated transcription factor 2 3
MIRT607769 HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2 6
MIRT607881 SATB1 SATB homeobox 1 2 2
MIRT607996 BTBD9 BTB domain containing 9 2 2
MIRT608124 TSC22D2 TSC22 domain family member 2 2 2
MIRT608132 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT608209 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT608337 SPN sialophorin 2 2
MIRT608416 SYNPO synaptopodin 2 5
MIRT608459 CD93 CD93 molecule 2 3
MIRT608555 SBK1 SH3 domain binding kinase 1 2 6
MIRT608585 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 4
MIRT608785 JAKMIP2 janus kinase and microtubule interacting protein 2 2 4
MIRT608791 CDH12 cadherin 12 2 2
MIRT608816 ONECUT3 one cut homeobox 3 2 6
MIRT608876 CNTF ciliary neurotrophic factor 2 6
MIRT608881 CLIC6 chloride intracellular channel 6 2 2
MIRT608894 ZNF860 zinc finger protein 860 2 2
MIRT608954 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609007 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 3
MIRT609045 INVS inversin 2 4
MIRT619037 CASS4 Cas scaffolding protein family member 4 2 2
MIRT625226 RPSAP58 ribosomal protein SA pseudogene 58 2 4
MIRT625545 GABRB2 gamma-aminobutyric acid type A receptor beta2 subunit 2 2
MIRT627333 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT627954 NLK nemo like kinase 2 2
MIRT629280 UNC13A unc-13 homolog A 2 2
MIRT634982 TNFAIP8 TNF alpha induced protein 8 2 2
MIRT646129 C1orf147 chromosome 1 open reading frame 147 2 2
MIRT646370 SLC22A6 solute carrier family 22 member 6 2 2
MIRT652743 TGFA transforming growth factor alpha 2 4
MIRT653984 SEMA6A semaphorin 6A 2 2
MIRT660038 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT663504 NKAPL NFKB activating protein like 2 4
MIRT667117 OCIAD2 OCIA domain containing 2 2 2
MIRT683747 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT683922 SLC43A3 solute carrier family 43 member 3 2 2
MIRT684101 LHFP LHFPL tetraspan subfamily member 6 2 2
MIRT684224 FGF14 fibroblast growth factor 14 2 2
MIRT685560 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687408 NRXN1 neurexin 1 2 2
MIRT687467 NHSL2 NHS like 2 2 2
MIRT687695 LEPREL1 prolyl 3-hydroxylase 2 1 1
MIRT688094 GLRA3 glycine receptor alpha 3 2 2
MIRT688255 FHL2 four and a half LIM domains 2 2 3
MIRT688851 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT700293 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT704679 CHST2 carbohydrate sulfotransferase 2 2 2
MIRT706392 PPID peptidylprolyl isomerase D 2 2
MIRT707388 SLC35F6 solute carrier family 35 member F6 2 2
MIRT707509 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT709808 AR androgen receptor 2 2
MIRT715491 MAZ MYC associated zinc finger protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6818-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6818-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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