miRTarBase - #MIRT490356


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pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DPYSL5   
Synonyms CRAM, CRMP-5, CRMP5, Ulip6
Description dihydropyrimidinase like 5
Transcript NM_020134   
Expression
Putative miRNA Targets on DPYSL5
3'UTR of DPYSL5
(miRNA target sites are highlighted)		 
>DPYSL5|NM_020134|3'UTR
   1 AGGCATTGCCAAGCCCCCCGAGTGAGGACGCACCGCCGCCACCAGCCCGCAACTCTCCAGCCGAAGCTGCAGGGGCAGGA
  81 GAGGCTGGGCTGGGTGGCACACCACCCGAGGGGGGCCCCGGGACCCACGGAGCCCTCCCTATGTCTGCAAAGTGATTCAC
 161 TGTGCTTCGAGCCAACTCTAACAGGCACTTTGAGATGTGTTCCTCCTGCTGTAGTCCTTTCTGCCTTGGCCTCGGCGGGC
 241 TTTTCTGGGGCCCAGGAAGCCCACACTATGCACAGAGCCCAATGCATAGAGCCCTGGCCAGCCCTTCCTCTCACTCCTGC
 321 CTCCGCTGGCTTTGGGAAAGCCCAGACTTTAGTGCCCTGCCCCCTGGCTGACTGGCCAGTTGCCCAGAGCACTTTAGCAG
 401 ATGTGGTTTCAAAGTAAAGGCCTCCTCCCCCACCCCTTAGGCCCCGTGGTGACATTTCCCAAGTCAGACAGATGTCAGCT
 481 TCCCAGCCATGCCCAGGACGTCCTATCTCCCCCAACCCACCTCTGGCCCTGTGTAGGGGCAGGGATGGGGGTGGCTGGGA
 561 CTCCTGGTGCCCCTCGCCAGCTTCTCCTGCGCCCCGCCCACACCCTCGGGGGGTCACAGGCCCAGAAGGGTAGCTGGGCG
 641 GGGCTCGAGGCTGGTGCCAGGCGCGTGTAAATGGTTTTGTTTTGCACGTTTGGTTTGCGCAGTAGTTTGGTTTGACTTGT
 721 TTGTGCATCCTGTGAAAAATAACGGTGCTTGTGTCACTAGCATAGAATAGCGACAGGAATAGATGTGGTCCTTAGGAGAC
 801 GCTGCACTTGACACCAACCAGACAGCACAGGGCAGGGGTGGTGGAGGGGGCTGGGCTCACAGGCCTCTCTTTTCCCCGCC
 881 TGCAGTCTTCTGGGCTGCGGGAGGCCCTGGCCCTTTCCCCTTCCCCTCCCCTCCTTGTCTAGTTTCCCACATTCCAAAAG
 961 GGGGCCTGGGATGCTAGCCCCAGAGATGCCAGCCCTTCAGGAAGCAGGTGTCCTTTCCCCTCTCTGCCCCTGATCACTCC
1041 CAGCACTCCCCTTGCCTTCCCCTGTCTTCACCTGCCACCACACACACACACACACACACACACACACACACACACGCACG
1121 GCTTCCTATAACTTCTTCCTGCTGGACAGAGACTCAGCGCTCCTCCTGTGTGACTGGCAAGAGGCCTCATGCCTGCTGAG
1201 AGAGGAGGAGTGGGAGAGGGGCTTGCCAGACACCAGAGAGGGAGACCCCAGGCCCACAGGACCTGGCTGTCGAACCCGCA
1281 TTGCTGCTCAGGTGCCGTGATCTCCCGTGGTCGGCACCAGGCCCTTGCCAGCTCATGGCCTCATCTTCTCCCCTGTCCAT
1361 CCAGGTGGGCCCTCCCTGCTTCTAAAGCCCCACAGAAGTTCCCATGGAAACACTAGAGGCCGGGTGTCTCCTTCCACCTC
1441 CAGTGATCTGGGAAGTGACCCAGCCGCCTGCCCTTGTTAAGCCTGGTCTGCCCCGTGGGAAGTGACTTCATGTTGCACAT
1521 GTGATTTCAGCCCCCGAGGCTTGCGCGAGGCTTCTGGACCCTCGGTTAAAGGTCAGCCCCTGGCCGGGTGCGGTGGCTCA
1601 CGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCATGGAGTCAGGAGATCGAGACCATCCTGGCTAACACG
1681 GTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGAGGAGG
1761 CTGAGGCAGGAGAATAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCACGCCACTGCACTTCAGCCTGGAC
1841 GACAGAGTGAGACTCCATCTCAAAAAACAGACAAACAAAAAAGTCAGCCCCTGCACATCTCTGTAGTGCTTTTCATGTAT
1921 TCAAACCACTTCCGTATATGACCTCTCACTTAGTCCTCATGACAATGGAGCACTTATTATTCTTCCCATTTTACAGATGA
2001 GGAAACTAAGACCCAGAAAGTTCAGGTCCTCTGACCCCAGAAGTGTCTGTGATGACCCTCCCAACCTTGGCTATCTACCC
2081 CACCTGTGGAGAGGAGGTCTGGGGTGACATCTATTGTAGATCCCACCTGAGAGTTTAACCAATGAGAAGACTTACTTTCC
2161 TGGTAGGCAGCCTGCTTTGTTTTGCACAGGAAGATAGATTTTTTTTCTCATCTTTCTTATAAACAACCTCATGCACATTC
2241 TGTGTTTGAGCCAAGACTAGTCACCCATTGGGGGCTAACCGTGCAGTGTGAGCTGCGTCCACACCCTCACTTCTCCCTTC
2321 ACTCCCCCTTTCCTCACTCAGGGGCTGAGAGGACAGAGGTGGTCAGCCGGGGAGCAGAGGTGGCGAAGGGGCTCATGGCA
2401 AGTGGCAGCCATTGGAACAGGGGTGAGGACCCAGGCCTGGGAAAGCCACCAGGGATGGGGGAAACCATGACGCCGCCTCC
2481 TGGTGCAGTGCACACCATCTCTATCCCTGTCAGCCCTCACTGGGTCATGGGCCTTGGGCAGATGTCAAAGAGCCCAGCAG
2561 CAGCGGTGGTGGCCAGCTGGGCAGAGCATCCTTGCTTGGGCTAGGAAAGCTTTACCTTCTCTGAGTGCCTCCGCCTGAGA
2641 GATGTGTGACCCGTGGCACCAGGGAACCACGTCTTGGAGTGGTCCACTGTAGGCCATGCGCTTCATCCACCCCCAGTCCC
2721 TACATAGGCCCTACCCTTGCCCGGGAGCTTCTAGATAGAAATCAGAAAGAGATTCAAGGAGCCAAATGAGCGGTCAGCCC
2801 CCACCATGCACTCCTTGCCCCGTGCAGAGCTCCAGCCAGCTTCGTCACCAGCCCCACTGGCTCCTGGTTGGAACGAAAGG
2881 GTCTCTGGTTGCACTGAATGCAGCTCTCAAACTGGTCTTGTACTTGCTGAATAAATACTGTTGTTCTTGCCTTAGCTGCT
2961 CTCTAGGTTTGTGGGGTTAAGTTGCCAGAAAATTGTGCTACTGTGTGTGCGTGTGCGTGCGTGTGTGTAGTGCTAGGAGT
3041 CCACAGTAGGTCTCTGTCAAGCCGATGTCGTGATGAGGGCTTTTCTGATACTGACCCAGAAGCCACAGAACCACAAGGAA
3121 ACCCAAACCCCCTCCAGCTGCTGAGGCGCAGGCACAGCCTGGGGTCGGATGGAGCCTCCAGCACCCCAGCACCCAGGTGA
3201 CTTCCCCACTCCCCTGTAAATGTCATGGTGCTAAGACTGTGTCAACCCCAAGACGACACATGGTCCTGTGCTTTGGCCAC
3281 CGTTTGAGGCAAAAACTAAACAGCCCGACACGTTGTGTTCTGGTGCAGGTTTGTATTAAACTGTAGCTACTTCTCAAAAA
3361 AAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acggaggagGUCCUAGGUGUGu 5'
                   | | :||||||| 
Target 5' cagtgtgagCTGCGTCCACACc 3'
 2284 - 2305 145.00 -12.00
2 
miRNA  3' acggaggaGGUCCU-AGGUGUgu 5'
                  |:|||| ||||||  
Target 5' gtgtagtgCTAGGAGTCCACAgt 3'
 3025 - 3047 138.00 -16.60
3 
miRNA  3' acGGAGGAGGUCC----UAGGUGUGu 5'
            || ||||| ||    :| ||||| 
Target 5' cgCCGCCTCCTGGTGCAGTGCACACc 3'
 2471 - 2496 134.00 -22.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32067441 3 COSMIC
COSN30165869 25 COSMIC
COSN31510039 29 COSMIC
COSN26974143 30 COSMIC
COSN30732020 35 COSMIC
COSN13987070 39 COSMIC
COSN30531808 54 COSMIC
COSN30138789 71 COSMIC
COSN31594073 79 COSMIC
COSN30543057 112 COSMIC
COSN30543168 113 COSMIC
COSN30168268 209 COSMIC
COSN31557164 225 COSMIC
COSN18887523 244 COSMIC
COSN30165872 371 COSMIC
COSN23903975 604 COSMIC
COSN24990720 616 COSMIC
COSN31589882 671 COSMIC
COSN26552516 689 COSMIC
COSN19422413 706 COSMIC
COSN17982284 830 COSMIC
COSN27984123 861 COSMIC
COSN9368986 900 COSMIC
COSN20096409 1113 COSMIC
COSN20096407 1115 COSMIC
COSN20096405 1116 COSMIC
COSN6682370 1120 COSMIC
COSN19543294 1308 COSMIC
COSN1834488 1471 COSMIC
COSN7243583 1565 COSMIC
COSN22191681 1616 COSMIC
COSN23385241 1787 COSMIC
COSN21181031 2112 COSMIC
COSN32062508 2190 COSMIC
COSN28122956 2217 COSMIC
COSN29901891 2246 COSMIC
COSN23561601 2369 COSMIC
COSN7243584 2757 COSMIC
COSN27871039 2876 COSMIC
COSN22092055 3256 COSMIC
COSN5865457 3283 COSMIC
COSN2516618 3287 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs76195421 4 dbSNP
rs1430551619 5 dbSNP
rs749199762 14 dbSNP
rs1281451223 15 dbSNP
rs770466140 15 dbSNP
rs201664895 20 dbSNP
rs777940661 21 dbSNP
rs746164447 22 dbSNP
rs1344325993 25 dbSNP
rs772556923 29 dbSNP
rs543669048 30 dbSNP
rs760378857 31 dbSNP
rs1012606765 32 dbSNP
rs1024091998 33 dbSNP
rs768319132 35 dbSNP
rs775963110 36 dbSNP
rs761831372 37 dbSNP
rs765025884 38 dbSNP
rs750236353 39 dbSNP
rs952292007 40 dbSNP
rs1201659377 42 dbSNP
rs985065431 43 dbSNP
rs773905823 45 dbSNP
rs1270287226 46 dbSNP
rs562763761 49 dbSNP
rs200503400 50 dbSNP
rs1024905975 55 dbSNP
rs1261574378 63 dbSNP
rs976164278 64 dbSNP
rs1488631184 65 dbSNP
rs1286477125 72 dbSNP
rs1485730632 76 dbSNP
rs1344650998 79 dbSNP
rs923384350 85 dbSNP
rs1256825677 89 dbSNP
rs978175026 92 dbSNP
rs551348432 94 dbSNP
rs560256417 95 dbSNP
rs1400587257 98 dbSNP
rs187171792 101 dbSNP
rs935900112 108 dbSNP
rs1054328114 109 dbSNP
rs35411807 110 dbSNP
rs933224103 113 dbSNP
rs1402406510 120 dbSNP
rs894304069 121 dbSNP
rs111795353 129 dbSNP
rs948593457 130 dbSNP
rs1177633118 133 dbSNP
rs1170566523 134 dbSNP
rs1476064796 139 dbSNP
rs940326756 142 dbSNP
rs1409891344 150 dbSNP
rs1441920762 155 dbSNP
rs1045852218 156 dbSNP
rs906965065 159 dbSNP
rs1452274900 161 dbSNP
rs898914268 162 dbSNP
rs549318626 169 dbSNP
rs993547812 170 dbSNP
rs1025961206 171 dbSNP
rs996085819 172 dbSNP
rs929715311 178 dbSNP
rs567810046 186 dbSNP
rs538186644 192 dbSNP
rs35774110 193 dbSNP
rs1353035351 211 dbSNP
rs79945326 231 dbSNP
rs1025167760 234 dbSNP
rs571936787 235 dbSNP
rs976286485 236 dbSNP
rs1232498040 237 dbSNP
rs1331163569 238 dbSNP
rs1410892172 249 dbSNP
rs1422186697 258 dbSNP
rs749112042 264 dbSNP
rs1162006968 265 dbSNP
rs768747823 269 dbSNP
rs966834939 270 dbSNP
rs1349203235 274 dbSNP
rs978603716 283 dbSNP
rs1456664327 292 dbSNP
rs1237330220 297 dbSNP
rs1204889469 298 dbSNP
rs1439351890 308 dbSNP
rs1032844348 317 dbSNP
rs925272772 318 dbSNP
rs1436652797 322 dbSNP
rs754819717 325 dbSNP
rs575154740 326 dbSNP
rs921764499 336 dbSNP
rs1375621148 353 dbSNP
rs990022431 355 dbSNP
rs1309535729 356 dbSNP
rs553756403 357 dbSNP
rs954510839 358 dbSNP
rs1395672636 362 dbSNP
rs1405331335 365 dbSNP
rs948521765 374 dbSNP
rs1455523430 375 dbSNP
rs1165617491 396 dbSNP
rs1174459649 419 dbSNP
rs1406088505 422 dbSNP
rs987416009 426 dbSNP
rs907788186 428 dbSNP
rs143249152 431 dbSNP
rs928481730 432 dbSNP
rs1213739974 446 dbSNP
rs937081295 447 dbSNP
rs1439225290 452 dbSNP
rs929058373 460 dbSNP
rs1325634046 463 dbSNP
rs1055930623 465 dbSNP
rs1375939445 466 dbSNP
rs895344808 489 dbSNP
rs192468454 490 dbSNP
rs1346635126 491 dbSNP
rs1305497554 500 dbSNP
rs554502249 501 dbSNP
rs1360006066 504 dbSNP
rs1268873228 506 dbSNP
rs183360892 508 dbSNP
rs751321272 509 dbSNP
rs887440583 511 dbSNP
rs1190352839 526 dbSNP
rs1005895227 535 dbSNP
rs1270907708 540 dbSNP
rs377663156 542 dbSNP
rs1332195717 543 dbSNP
rs767312177 548 dbSNP
rs1212903316 551 dbSNP
rs543223089 562 dbSNP
rs1260841164 567 dbSNP
rs1217487496 571 dbSNP
rs1039271794 573 dbSNP
rs900766265 576 dbSNP
rs370474570 577 dbSNP
rs1190955539 578 dbSNP
rs1241400430 579 dbSNP
rs1324761387 589 dbSNP
rs999490638 591 dbSNP
rs1030479302 592 dbSNP
rs35077823 596 dbSNP
rs967307943 596 dbSNP
rs774240267 597 dbSNP
rs1470080186 601 dbSNP
rs1460065566 607 dbSNP
rs373788010 608 dbSNP
rs397708366 608 dbSNP
rs61089591 608 dbSNP
rs1187708382 609 dbSNP
rs1236498065 609 dbSNP
rs1203933798 610 dbSNP
rs957992770 615 dbSNP
rs1462029361 626 dbSNP
rs907798080 630 dbSNP
rs374010629 636 dbSNP
rs576683489 637 dbSNP
rs1217334623 640 dbSNP
rs990787601 641 dbSNP
rs1395686474 645 dbSNP
rs1216361649 647 dbSNP
rs755044280 648 dbSNP
rs1336295646 656 dbSNP
rs761679347 663 dbSNP
rs1329114284 664 dbSNP
rs915806199 665 dbSNP
rs767460390 666 dbSNP
rs545002389 674 dbSNP
rs560108928 688 dbSNP
rs1172489431 699 dbSNP
rs981795872 700 dbSNP
rs920296167 703 dbSNP
rs928480439 707 dbSNP
rs1446153309 713 dbSNP
rs1245344514 720 dbSNP
rs936989208 724 dbSNP
rs1480528405 726 dbSNP
rs1353251161 733 dbSNP
rs376956082 744 dbSNP
rs772740233 745 dbSNP
rs1273364124 746 dbSNP
rs1358232315 749 dbSNP
rs1319967197 752 dbSNP
rs1314534286 758 dbSNP
rs1246967477 759 dbSNP
rs1055581561 765 dbSNP
rs1307355857 768 dbSNP
rs1390567575 771 dbSNP
rs916982311 773 dbSNP
rs760437526 784 dbSNP
rs1456368145 789 dbSNP
rs1447499152 801 dbSNP
rs1163733616 802 dbSNP
rs1445943386 807 dbSNP
rs1378054764 810 dbSNP
rs1194559875 815 dbSNP
rs1177650209 816 dbSNP
rs1418837400 819 dbSNP
rs557903394 820 dbSNP
rs527817919 824 dbSNP
rs1474231628 832 dbSNP
rs908972579 833 dbSNP
rs1187524544 838 dbSNP
rs1487823061 839 dbSNP
rs1291705950 846 dbSNP
rs1223229833 851 dbSNP
rs941649855 858 dbSNP
rs1284090718 863 dbSNP
rs1459808973 868 dbSNP
rs549437806 870 dbSNP
rs902786850 870 dbSNP
rs969682414 874 dbSNP
rs187472096 878 dbSNP
rs900190226 879 dbSNP
rs1300516919 885 dbSNP
rs1054429260 886 dbSNP
rs997764147 899 dbSNP
rs147504803 900 dbSNP
rs1413579566 907 dbSNP
rs138412419 911 dbSNP
rs1029120519 912 dbSNP
rs890508634 930 dbSNP
rs1364722270 932 dbSNP
rs1236686933 950 dbSNP
rs79654310 956 dbSNP
rs1351041490 961 dbSNP
rs1014739815 965 dbSNP
rs1200813236 968 dbSNP
rs961853805 971 dbSNP
rs1032354167 974 dbSNP
rs1261181569 983 dbSNP
rs958128617 991 dbSNP
rs1204769030 993 dbSNP
rs1012309842 1002 dbSNP
rs1262731230 1009 dbSNP
rs1230707527 1011 dbSNP
rs1322580598 1013 dbSNP
rs879387899 1014 dbSNP
rs1406735664 1024 dbSNP
rs1337764097 1027 dbSNP
rs1317094200 1028 dbSNP
rs1382311710 1029 dbSNP
rs375382549 1033 dbSNP
rs971170743 1040 dbSNP
rs868015554 1041 dbSNP
rs981381204 1047 dbSNP
rs547457524 1052 dbSNP
rs1429087679 1061 dbSNP
rs1425773322 1063 dbSNP
rs1177746475 1065 dbSNP
rs928547277 1078 dbSNP
rs1227468048 1079 dbSNP
rs1327707366 1079 dbSNP
rs1331691628 1079 dbSNP
rs1331768413 1079 dbSNP
rs1376091782 1079 dbSNP
rs1405804108 1079 dbSNP
rs141571245 1079 dbSNP
rs1451515844 1079 dbSNP
rs67138052 1079 dbSNP
rs748746544 1079 dbSNP
rs768282341 1079 dbSNP
rs775866642 1079 dbSNP
rs879049319 1079 dbSNP
rs879055912 1079 dbSNP
rs879097415 1079 dbSNP
rs1363589796 1081 dbSNP
rs1440640048 1082 dbSNP
rs1471170719 1082 dbSNP
rs1167878667 1086 dbSNP
rs950548611 1086 dbSNP
rs983299057 1087 dbSNP
rs1374899266 1090 dbSNP
rs1475768639 1090 dbSNP
rs908936591 1097 dbSNP
rs1181969829 1099 dbSNP
rs866402255 1099 dbSNP
rs1161000254 1101 dbSNP
rs1382998154 1101 dbSNP
rs1316727539 1108 dbSNP
rs1454882069 1108 dbSNP
rs1353169546 1109 dbSNP
rs1411078612 1109 dbSNP
rs111431497 1113 dbSNP
rs1398704285 1113 dbSNP
rs921604286 1114 dbSNP
rs1468390936 1115 dbSNP
rs933019113 1115 dbSNP
rs1433613036 1116 dbSNP
rs1051981888 1117 dbSNP
rs13017554 1120 dbSNP
rs935484300 1127 dbSNP
rs1221003675 1134 dbSNP
rs949776483 1136 dbSNP
rs1293435561 1142 dbSNP
rs543674435 1151 dbSNP
rs924136689 1157 dbSNP
rs1053863883 1159 dbSNP
rs1336148775 1160 dbSNP
rs1337982548 1161 dbSNP
rs1301870784 1163 dbSNP
rs1404357683 1167 dbSNP
rs1366323768 1171 dbSNP
rs1165674558 1186 dbSNP
rs1241996199 1209 dbSNP
rs1399245068 1215 dbSNP
rs1301206740 1222 dbSNP
rs935485497 1239 dbSNP
rs1158871896 1248 dbSNP
rs894006177 1249 dbSNP
rs1266639956 1251 dbSNP
rs1198633412 1253 dbSNP
rs535991711 1260 dbSNP
rs1490360896 1265 dbSNP
rs1347034305 1272 dbSNP
rs555863251 1273 dbSNP
rs1256662928 1275 dbSNP
rs1484240808 1279 dbSNP
rs1023714544 1283 dbSNP
rs878974814 1291 dbSNP
rs1284524440 1298 dbSNP
rs1194309291 1301 dbSNP
rs1224645342 1302 dbSNP
rs778948893 1307 dbSNP
rs572370758 1308 dbSNP
rs1050825737 1312 dbSNP
rs1035586396 1314 dbSNP
rs950712855 1318 dbSNP
rs576020425 1322 dbSNP
rs1190403953 1324 dbSNP
rs537257805 1325 dbSNP
rs1251740273 1327 dbSNP
rs1428738380 1330 dbSNP
rs1344767196 1340 dbSNP
rs1454216443 1345 dbSNP
rs1402184019 1354 dbSNP
rs1175608814 1370 dbSNP
rs755426240 1370 dbSNP
rs10181727 1383 dbSNP
rs1431365997 1386 dbSNP
rs1184186235 1389 dbSNP
rs192177517 1390 dbSNP
rs1166992564 1406 dbSNP
rs974485227 1409 dbSNP
rs958838332 1410 dbSNP
rs921679433 1414 dbSNP
rs1448785622 1421 dbSNP
rs1261734753 1422 dbSNP
rs115606226 1423 dbSNP
rs1324825675 1424 dbSNP
rs758752972 1425 dbSNP
rs560146180 1435 dbSNP
rs1212844308 1436 dbSNP
rs572132271 1438 dbSNP
rs1270969166 1447 dbSNP
rs1303245560 1450 dbSNP
rs868795909 1453 dbSNP
rs58866631 1455 dbSNP
rs1403614188 1460 dbSNP
rs935572549 1464 dbSNP
rs1470126007 1466 dbSNP
rs182406620 1467 dbSNP
rs1168263493 1478 dbSNP
rs893975732 1484 dbSNP
rs1419660279 1487 dbSNP
rs948226641 1492 dbSNP
rs1045123515 1493 dbSNP
rs906625874 1494 dbSNP
rs1187902041 1495 dbSNP
rs187039377 1496 dbSNP
rs1242160461 1497 dbSNP
rs1203361189 1499 dbSNP
rs1251526765 1511 dbSNP
rs1258239934 1512 dbSNP
rs932199074 1522 dbSNP
rs1306965128 1530 dbSNP
rs1003524412 1535 dbSNP
rs1026044933 1536 dbSNP
rs887141258 1537 dbSNP
rs1230715138 1545 dbSNP
rs139667325 1546 dbSNP
rs192136240 1547 dbSNP
rs532890947 1556 dbSNP
rs1296346602 1562 dbSNP
rs944680722 1565 dbSNP
rs1016226585 1572 dbSNP
rs1426256958 1573 dbSNP
rs1191815128 1578 dbSNP
rs1423971034 1586 dbSNP
rs1422219365 1587 dbSNP
rs1466862107 1591 dbSNP
rs113182971 1592 dbSNP
rs533251777 1593 dbSNP
rs1458177823 1596 dbSNP
rs1445601246 1597 dbSNP
rs757505197 1598 dbSNP
rs1359745255 1599 dbSNP
rs1380654160 1600 dbSNP
rs548086910 1602 dbSNP
rs954633377 1603 dbSNP
rs994687315 1616 dbSNP
rs987268219 1619 dbSNP
rs1357398206 1629 dbSNP
rs1291289440 1632 dbSNP
rs368555867 1636 dbSNP
rs956413704 1645 dbSNP
rs1024164498 1652 dbSNP
rs989653342 1660 dbSNP
rs1402503574 1661 dbSNP
rs1220710255 1670 dbSNP
rs529706730 1680 dbSNP
rs547833167 1681 dbSNP
rs1361717130 1682 dbSNP
rs998475579 1689 dbSNP
rs1418890027 1690 dbSNP
rs948196871 1691 dbSNP
rs567886661 1692 dbSNP
rs1268352550 1694 dbSNP
rs928179933 1698 dbSNP
rs543265094 1700 dbSNP
rs957316473 1708 dbSNP
rs1238010535 1719 dbSNP
rs184681486 1720 dbSNP
rs1485172750 1723 dbSNP
rs536741977 1724 dbSNP
rs190359205 1730 dbSNP
rs563150002 1731 dbSNP
rs745984447 1732 dbSNP
rs887102562 1735 dbSNP
rs570293055 1736 dbSNP
rs1424220187 1744 dbSNP
rs1005556829 1746 dbSNP
rs1413212270 1752 dbSNP
rs534484064 1753 dbSNP
rs915416175 1754 dbSNP
rs953557592 1755 dbSNP
rs986412902 1756 dbSNP
rs1200154896 1758 dbSNP
rs912144201 1765 dbSNP
rs1037587289 1768 dbSNP
rs1204829002 1769 dbSNP
rs944690740 1770 dbSNP
rs1269863266 1777 dbSNP
rs1201680221 1778 dbSNP
rs1298670685 1779 dbSNP
rs1036330183 1780 dbSNP
rs899094383 1784 dbSNP
rs919362350 1786 dbSNP
rs1291704259 1787 dbSNP
rs552867587 1788 dbSNP
rs930699118 1789 dbSNP
rs1181136657 1790 dbSNP
rs1029224181 1792 dbSNP
rs1173699663 1794 dbSNP
rs1315270143 1795 dbSNP
rs1049126916 1797 dbSNP
rs574606577 1812 dbSNP
rs543012184 1815 dbSNP
rs1009060719 1816 dbSNP
rs10205099 1820 dbSNP
rs1489002805 1822 dbSNP
rs956340682 1824 dbSNP
rs1460719152 1828 dbSNP
rs1208060640 1831 dbSNP
rs1045665793 1840 dbSNP
rs1256429620 1841 dbSNP
rs193289578 1842 dbSNP
rs1183171166 1844 dbSNP
rs1405536094 1849 dbSNP
rs998486896 1850 dbSNP
rs144183483 1858 dbSNP
rs969596446 1861 dbSNP
rs1159212140 1867 dbSNP
rs774399761 1867 dbSNP
rs532775014 1869 dbSNP
rs1011768914 1871 dbSNP
rs1382059048 1871 dbSNP
rs1394410662 1872 dbSNP
rs928113000 1875 dbSNP
rs139962404 1876 dbSNP
rs1430516089 1877 dbSNP
rs953711483 1882 dbSNP
rs939573181 1883 dbSNP
rs548687702 1890 dbSNP
rs1443747765 1895 dbSNP
rs1237907247 1896 dbSNP
rs1311128381 1899 dbSNP
rs1358872883 1901 dbSNP
rs1449039632 1909 dbSNP
rs912155578 1915 dbSNP
rs966255113 1921 dbSNP
rs1195830900 1925 dbSNP
rs1304751262 1929 dbSNP
rs972077026 1935 dbSNP
rs185091464 1937 dbSNP
rs1285219199 1940 dbSNP
rs1450656049 1948 dbSNP
rs771984016 1950 dbSNP
rs1334440722 1955 dbSNP
rs1310681976 1956 dbSNP
rs535571424 1968 dbSNP
rs1328795175 1972 dbSNP
rs1410487279 1973 dbSNP
rs930648811 1976 dbSNP
rs1161895966 1978 dbSNP
rs530281122 1983 dbSNP
rs528110918 1989 dbSNP
rs1424324932 1998 dbSNP
rs1049647255 1999 dbSNP
rs941313098 2002 dbSNP
rs143406980 2004 dbSNP
rs569538076 2018 dbSNP
rs551350200 2021 dbSNP
rs1182873366 2034 dbSNP
rs907144120 2037 dbSNP
rs996489223 2042 dbSNP
rs1053026269 2045 dbSNP
rs1451765882 2056 dbSNP
rs114813754 2057 dbSNP
rs1230336024 2059 dbSNP
rs1011237325 2060 dbSNP
rs1028491276 2068 dbSNP
rs1230773475 2070 dbSNP
rs796906641 2075 dbSNP
rs1007744562 2078 dbSNP
rs1019099270 2079 dbSNP
rs890247804 2082 dbSNP
rs551877787 2084 dbSNP
rs1325800916 2088 dbSNP
rs1030680924 2098 dbSNP
rs1240008482 2106 dbSNP
rs570179984 2110 dbSNP
rs1159809633 2112 dbSNP
rs1010636706 2115 dbSNP
rs1473567243 2117 dbSNP
rs1452494305 2126 dbSNP
rs1197988427 2128 dbSNP
rs1478089968 2129 dbSNP
rs534519746 2143 dbSNP
rs1172867375 2145 dbSNP
rs966182996 2147 dbSNP
rs972337532 2157 dbSNP
rs1267954374 2160 dbSNP
rs1021905808 2168 dbSNP
rs115665786 2172 dbSNP
rs1281963049 2181 dbSNP
rs1178544789 2185 dbSNP
rs984804947 2188 dbSNP
rs1218672656 2194 dbSNP
rs981426473 2196 dbSNP
rs1276800437 2197 dbSNP
rs1428971287 2199 dbSNP
rs1344376076 2201 dbSNP
rs1035279608 2206 dbSNP
rs1057115 2207 dbSNP
rs1446579059 2208 dbSNP
rs982982537 2209 dbSNP
rs948790644 2212 dbSNP
rs908603117 2215 dbSNP
rs1175673760 2221 dbSNP
rs535376810 2228 dbSNP
rs941406545 2234 dbSNP
rs760181215 2237 dbSNP
rs766090510 2247 dbSNP
rs1426736720 2248 dbSNP
rs188966801 2251 dbSNP
rs1474842985 2258 dbSNP
rs550457027 2269 dbSNP
rs921263872 2273 dbSNP
rs1466546657 2274 dbSNP
rs1274724942 2281 dbSNP
rs576336083 2282 dbSNP
rs934463101 2285 dbSNP
rs543811078 2287 dbSNP
rs1280898910 2289 dbSNP
rs1364649522 2296 dbSNP
rs1298651910 2297 dbSNP
rs759012387 2302 dbSNP
rs890392368 2306 dbSNP
rs893052587 2310 dbSNP
rs1466538036 2323 dbSNP
rs1360839051 2325 dbSNP
rs947076730 2326 dbSNP
rs944516344 2329 dbSNP
rs1270506337 2333 dbSNP
rs1170146624 2340 dbSNP
rs1052203423 2341 dbSNP
rs1316906648 2351 dbSNP
rs181654005 2360 dbSNP
rs61742729 2369 dbSNP
rs146716835 2370 dbSNP
rs559685735 2383 dbSNP
rs575115908 2386 dbSNP
rs1001882948 2400 dbSNP
rs1275578165 2404 dbSNP
rs1478422313 2407 dbSNP
rs542141065 2410 dbSNP
rs1311671545 2412 dbSNP
rs879111591 2422 dbSNP
rs1417713183 2423 dbSNP
rs1465298184 2424 dbSNP
rs1027020410 2425 dbSNP
rs1296405408 2439 dbSNP
rs1171577841 2452 dbSNP
rs563983423 2455 dbSNP
rs530442398 2456 dbSNP
rs1022944799 2457 dbSNP
rs970005324 2459 dbSNP
rs551717070 2460 dbSNP
rs1332156688 2463 dbSNP
rs763462843 2465 dbSNP
rs1015756649 2466 dbSNP
rs928686113 2471 dbSNP
rs1438059307 2472 dbSNP
rs764298012 2473 dbSNP
rs1267890985 2475 dbSNP
rs974114629 2476 dbSNP
rs751983499 2480 dbSNP
rs1489901242 2488 dbSNP
rs921358682 2495 dbSNP
rs34709563 2505 dbSNP
rs1265113929 2506 dbSNP
rs1245183644 2508 dbSNP
rs1323333308 2510 dbSNP
rs1304745414 2514 dbSNP
rs932616351 2516 dbSNP
rs947307037 2521 dbSNP
rs57370731 2523 dbSNP
rs1389520328 2534 dbSNP
rs986838690 2538 dbSNP
rs757374181 2545 dbSNP
rs910904237 2547 dbSNP
rs781455118 2549 dbSNP
rs943651614 2553 dbSNP
rs1157567089 2562 dbSNP
rs563843937 2563 dbSNP
rs528171126 2565 dbSNP
rs546431236 2566 dbSNP
rs140294861 2582 dbSNP
rs1266913379 2600 dbSNP
rs1210703366 2627 dbSNP
rs1489338311 2628 dbSNP
rs946553526 2629 dbSNP
rs888047880 2633 dbSNP
rs1043420848 2634 dbSNP
rs904952391 2638 dbSNP
rs1207892667 2642 dbSNP
rs535769288 2653 dbSNP
rs550622674 2654 dbSNP
rs1221104597 2660 dbSNP
rs1223959620 2666 dbSNP
rs896168908 2671 dbSNP
rs1301507751 2672 dbSNP
rs1261135431 2673 dbSNP
rs1388206159 2682 dbSNP
rs1004460040 2684 dbSNP
rs1318870731 2685 dbSNP
rs1457071784 2687 dbSNP
rs1389954277 2691 dbSNP
rs1002827743 2692 dbSNP
rs1035772729 2694 dbSNP
rs569098869 2700 dbSNP
rs537449973 2701 dbSNP
rs914431024 2705 dbSNP
rs968927730 2707 dbSNP
rs1465204924 2710 dbSNP
rs761293345 2710 dbSNP
rs1269904853 2711 dbSNP
rs558943956 2712 dbSNP
rs1392165089 2713 dbSNP
rs1343674282 2717 dbSNP
rs1028803976 2723 dbSNP
rs1234804734 2725 dbSNP
rs577458574 2730 dbSNP
rs1305354294 2733 dbSNP
rs756258657 2734 dbSNP
rs780344348 2735 dbSNP
rs987321381 2736 dbSNP
rs371603571 2743 dbSNP
rs1394869929 2744 dbSNP
rs918367366 2745 dbSNP
rs866692034 2751 dbSNP
rs535110456 2756 dbSNP
rs887962406 2758 dbSNP
rs765948548 2764 dbSNP
rs1449817893 2767 dbSNP
rs1249718478 2770 dbSNP
rs987977150 2776 dbSNP
rs1441717610 2778 dbSNP
rs72851901 2784 dbSNP
rs1201635203 2791 dbSNP
rs144018388 2792 dbSNP
rs150957379 2793 dbSNP
rs1002860114 2794 dbSNP
rs1035637844 2796 dbSNP
rs185547089 2801 dbSNP
rs1300189344 2803 dbSNP
rs1340339960 2806 dbSNP
rs926471794 2807 dbSNP
rs1397825069 2810 dbSNP
rs575488526 2811 dbSNP
rs868795433 2814 dbSNP
rs1022094413 2815 dbSNP
rs1392275405 2816 dbSNP
rs188690951 2819 dbSNP
rs896114401 2822 dbSNP
rs375409822 2823 dbSNP
rs772054976 2830 dbSNP
rs1250515035 2834 dbSNP
rs1037257798 2839 dbSNP
rs911174755 2841 dbSNP
rs965274126 2844 dbSNP
rs1289170238 2845 dbSNP
rs545428186 2847 dbSNP
rs1356138800 2849 dbSNP
rs1285275606 2851 dbSNP
rs528207199 2856 dbSNP
rs1348701749 2862 dbSNP
rs1287746080 2867 dbSNP
rs976437505 2869 dbSNP
rs555926410 2875 dbSNP
rs1321877520 2876 dbSNP
rs546356693 2884 dbSNP
rs1404528806 2894 dbSNP
rs954387776 2904 dbSNP
rs1391261078 2909 dbSNP
rs1164925546 2913 dbSNP
rs929600264 2925 dbSNP
rs1411165579 2936 dbSNP
rs983891870 2939 dbSNP
rs1008307635 2950 dbSNP
rs1473303625 2962 dbSNP
rs1244587347 2967 dbSNP
rs140746765 2980 dbSNP
rs770668848 2996 dbSNP
rs1473952161 3003 dbSNP
rs1157418646 3004 dbSNP
rs956008101 3006 dbSNP
rs1215960678 3007 dbSNP
rs942248290 3007 dbSNP
rs1327645679 3008 dbSNP
rs1380194476 3011 dbSNP
rs988787651 3012 dbSNP
rs772845047 3013 dbSNP
rs1299489644 3015 dbSNP
rs180823018 3017 dbSNP
rs967920789 3018 dbSNP
rs938955786 3020 dbSNP
rs150083824 3021 dbSNP
rs759239454 3022 dbSNP
rs1159867718 3030 dbSNP
rs937881225 3032 dbSNP
rs1056182594 3050 dbSNP
rs1422513422 3065 dbSNP
rs371501362 3071 dbSNP
rs1478111201 3086 dbSNP
rs769235078 3096 dbSNP
rs939642554 3099 dbSNP
rs867482495 3113 dbSNP
rs1036679319 3118 dbSNP
rs904597898 3130 dbSNP
rs1247929290 3131 dbSNP
rs1209968072 3141 dbSNP
rs1354307576 3144 dbSNP
rs898192076 3147 dbSNP
rs569058879 3148 dbSNP
rs1006756311 3149 dbSNP
rs539739992 3150 dbSNP
rs931544435 3157 dbSNP
rs1345918230 3160 dbSNP
rs1305936483 3168 dbSNP
rs1432595198 3174 dbSNP
rs1200114589 3175 dbSNP
rs1050467250 3176 dbSNP
rs186217714 3181 dbSNP
rs1437267715 3183 dbSNP
rs1444535703 3187 dbSNP
rs774174083 3201 dbSNP
rs1174691302 3222 dbSNP
rs1414579983 3231 dbSNP
rs1177135739 3254 dbSNP
rs759214258 3255 dbSNP
rs570841093 3256 dbSNP
rs1025946569 3262 dbSNP
rs1189617111 3266 dbSNP
rs1160908172 3267 dbSNP
rs1487103838 3270 dbSNP
rs143845671 3277 dbSNP
rs1209458340 3282 dbSNP
rs553209588 3283 dbSNP
rs1282711485 3287 dbSNP
rs1010301306 3301 dbSNP
rs1021569096 3306 dbSNP
rs909663720 3307 dbSNP
rs1172838981 3310 dbSNP
rs1376841331 3312 dbSNP
rs577917496 3312 dbSNP
rs1302237667 3313 dbSNP
rs1448099528 3317 dbSNP
rs979370866 3321 dbSNP
rs1305792559 3326 dbSNP
rs980465988 3329 dbSNP
rs141830050 3334 dbSNP
rs1034021907 3353 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395166. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 1 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggaggagguccuaGGUGUGu 5'
                         |||||| 
Target 5' -------------caCCACACa 3'
 		1 - 9
2 
miRNA  3' acggaggagguccuagGUGUGu 5'
                          ||||| 
Target 5' cacacacacacacacaCACACa 3'
 		12 - 33
Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_020134 | 3UTR | ACACACACACACACACACACACACACACACACGCACGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_020134 | 3UTR | ACACACACACACACACACACACACACACACACACGCACGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_020134 | 3UTR | ACACACACACACACACACACACACACACACACACGCACGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1395166
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 1
Location of target site ENST00000288699.6 | 3UTR | CACCACACACACACACACACACACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000288699.6 | 3UTR | UCUUCACCUGCCACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.471 0.21 -0.600 0.14 5 Click to see details
LUSC -0.443 0.28 -0.400 0.3 4 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
HNSC -0.195 0.34 0.214 0.32 7 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission