miRTarBase - #MIRT490462


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pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PROSER2   
Synonyms C10orf47
Description proline and serine rich 2
Transcript NM_153256   
Expression
Putative miRNA Targets on PROSER2
3'UTR of PROSER2
(miRNA target sites are highlighted)		 
>PROSER2|NM_153256|3'UTR
   1 GGGCCGCGCGGGCTCCAGTCCACCCCGTTTCTCCCCACCCTGAAGAGAGGGTGAAAGAGTCGCTGCACCCAGGAGCTGTT
  81 TGGTCTAAAATGGAAGTGACAGCGGGAGCCCCTGCCCTCTGTGGCACATCGGAGTCTAGAGGTGCCTGGCTGGGGCCTCC
 161 TGGCTGAGCACGCACCGCAAGCTCCAGCCACCGGCACAGAGAACTCTTCCCTAAAGGAATCTGGCCGAGGGCTTGTCTCC
 241 CTTTTCCCAAGAACTGAGAGAGAGAGAATAACCTGTTAGACCCATAGGTTTCCGTGATGTGTAAATGCCATCTTTTGGGG
 321 GTTGGGAGGAGTAGGACTGGTCTGATTATCATTCTTGAGTCTCATCTACCCTCTTCTCGAAGTACATGACATGAAAGTTC
 401 AGATCCCTTCCACTCAGGATTCTCGCCGCCTTTTCTAAGAAAATAATAAAAAAAAATGCTTGTTTCATTTTTTAATGTCT
 481 TAATATACTTGCTTTTGTTTTTGAAGGGTGAGGCATCATGGTACTTTGCTTTTGTTTCTTGACGTACTTTAGTTTGCCCA
 561 GTTTTGTTTTTTACTGAAAACTGAAATGAAACCTTTAGATATTGAGTTTTGGGAGTGAAATGGAAAGGTGGTAATTTTGA
 641 GAAAGCAAGTCTCATCAGACTCTGAGGTCTGGGACGTGTGCGTGAGCCTGTGTTTGTGTGTGTATGTTTTTAGATACGTA
 721 CGTGTCAACACATACATGCATAGGTATCCTGTGTGTCCACATGCATCATTATTATATAAATAGAAACTTCTGAACACCCT
 801 CCTAAGTCACTACAGGATGCCAGCGCTTCCTATTCTTGGGTAGACAGAGCCACCTCAGCATCCTGATGGATGATACAAGA
 881 AATTGTTACTTCCTAGTATGGAAGTGTCTTAAGGACACGTCTCCATGATATTTTGGTGAACCAAAAGTGCTTTATCCTCA
 961 ACAAAATGTTCCTCTGTTCCCAGTTAAAGTAATATTCCCTGCTTCCAAGTAAGCAAGACTGTTCACTAAAGAAGGAACTT
1041 TTTAGAAAACTAATCTCCTTTATCATCCAATTTTAGTTCTGCATGTTCCGAGGTAGCCAGTCAACAGAAGGAAGCAAAAG
1121 ATTCTTAAAGATCCACCGACTGTCATGTTCCACAAGCAAGATCTCAGGGTAGGGAAAAACCAGTGAATGAGGTTACACAG
1201 CAGGAAAAGAACCGGTTTCCTCCCAGACTATGTCTTACACGCTGAGTTATGCCACAAGCGTTATCATCAAAACTATTTAA
1281 GGCTGGAGTCTTAGACCTCTAAAAATAGACAGGAAGGGCTGCCCTGAGCAGTGACACCTTTGTGTTTTTATGTCTCCGCC
1361 AGCGCCGTAACAGAGCCTGTTTCTTTCCCGTTGAGTATTACTTAAATTCAGGCTTAAATGTGCTATGAAGGGCATTTTTC
1441 ATAGTATCCCATTTGCCTTGTAAGTTATATAAAGTGCATGATTATAATTTTTTCCTTAGAAATGCAATATTTAGTTTCAT
1521 CCAGCTCTTATGAATAATAACCTCATAGATTCCTGATCTTAATTTAAATAGGTGCTTTAATTTTACAGCTTTCAAAAGTA
1601 GTTACTGTAAATTTTACTCCTGTTAATGCTGGATTGGTTTAAAGGATTTATAAGGGCTGTGTTTGCTCTTTACAAGGCAA
1681 GATGCCATACAGTGTTCAATAATAGAAGGTCTTGATACAACCGACATTTTAAATATTCTTTATACATGAGGACTGCATCT
1761 TTTTCACTGACCCTATGATTTCACTGTGAGTAGGGTGAACTGGACTGCATATTAGTTTATTTGTTGCCATAATCACATTT
1841 TTGAAAAATAAATTTAAGAGTTTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauCGGAGGUACU-UAAGACUAc 5'
             |:|||||||| |||:||:| 
Target 5' cacGTCTCCATGATATTTTGGTg 3'
 916 - 938 151.00 -24.00
2 
miRNA  3' gaUCGGAGGUACUUAA-GACUAc 5'
            | ||| ||| :||| ||||| 
Target 5' atAACCT-CATAGATTCCTGATc 3'
 1537 - 1558 135.00 -10.80
3 
miRNA  3' gaUCGGAGGUA--CUUAAGACUAc 5'
            |||| || |  | || ||||| 
Target 5' agAGCCACC-TCAGCATCCTGATg 3'
 846 - 868 129.00 -15.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30731420 9 COSMIC
COSN30537508 10 COSMIC
COSN6475830 27 COSMIC
COSN19771002 28 COSMIC
COSN23012257 268 COSMIC
COSN6058164 333 COSMIC
COSN31547198 355 COSMIC
COSN26957771 376 COSMIC
COSN30172613 436 COSMIC
COSN31529056 440 COSMIC
COSN30127919 443 COSMIC
COSN23012258 457 COSMIC
COSN31483281 457 COSMIC
COSN30537425 525 COSMIC
COSN19361967 741 COSMIC
COSN26473213 909 COSMIC
COSN24577491 1363 COSMIC
COSN25382112 1410 COSMIC
COSN17037795 1479 COSMIC
COSN21848631 1500 COSMIC
COSN21625571 1601 COSMIC
COSN21223417 1868 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1412407568 4 dbSNP
rs774712871 6 dbSNP
rs758487000 7 dbSNP
rs1466870624 8 dbSNP
rs1480575243 9 dbSNP
rs959124016 11 dbSNP
rs1265912477 12 dbSNP
rs777642908 14 dbSNP
rs1425014012 15 dbSNP
rs1408907497 16 dbSNP
rs1170532565 17 dbSNP
rs1051554933 19 dbSNP
rs568187783 21 dbSNP
rs1301683287 22 dbSNP
rs1440787260 23 dbSNP
rs888775436 23 dbSNP
rs1405807742 25 dbSNP
rs12253600 27 dbSNP
rs1255958929 30 dbSNP
rs1360126811 32 dbSNP
rs1037947381 34 dbSNP
rs1024817136 36 dbSNP
rs781037914 37 dbSNP
rs745789964 40 dbSNP
rs1290784150 44 dbSNP
rs1490465446 45 dbSNP
rs1224403822 46 dbSNP
rs182610629 48 dbSNP
rs577089253 49 dbSNP
rs983806386 51 dbSNP
rs907866731 58 dbSNP
rs1230850168 60 dbSNP
rs1339435619 61 dbSNP
rs187116307 63 dbSNP
rs963732101 67 dbSNP
rs993644960 68 dbSNP
rs973500478 69 dbSNP
rs921989749 71 dbSNP
rs1288175914 83 dbSNP
rs1329683278 85 dbSNP
rs1401594036 92 dbSNP
rs1465454884 92 dbSNP
rs906584423 97 dbSNP
rs1004029336 109 dbSNP
rs1223022302 111 dbSNP
rs146702532 113 dbSNP
rs1425737052 126 dbSNP
rs1236603368 132 dbSNP
rs959623067 138 dbSNP
rs374577235 145 dbSNP
rs116941868 146 dbSNP
rs377645204 147 dbSNP
rs1355011657 148 dbSNP
rs977188836 149 dbSNP
rs1246389751 152 dbSNP
rs573357078 153 dbSNP
rs1470309112 154 dbSNP
rs924437474 157 dbSNP
rs1042387545 158 dbSNP
rs542453418 160 dbSNP
rs1333942038 163 dbSNP
rs1162214973 165 dbSNP
rs746872009 169 dbSNP
rs1390677745 172 dbSNP
rs1163860455 173 dbSNP
rs114218014 177 dbSNP
rs531032232 178 dbSNP
rs140272057 181 dbSNP
rs1178329674 200 dbSNP
rs894857839 202 dbSNP
rs1239830293 208 dbSNP
rs1012011589 211 dbSNP
rs1037392491 216 dbSNP
rs1024807143 217 dbSNP
rs1211050713 225 dbSNP
rs1350871166 226 dbSNP
rs564486631 227 dbSNP
rs751467208 228 dbSNP
rs1333486171 230 dbSNP
rs557122762 232 dbSNP
rs1048041791 235 dbSNP
rs1447593864 236 dbSNP
rs755360197 237 dbSNP
rs906692969 241 dbSNP
rs533396199 242 dbSNP
rs1358764431 249 dbSNP
rs759670275 249 dbSNP
rs1420586868 252 dbSNP
rs1010823129 256 dbSNP
rs192049291 256 dbSNP
rs578159868 256 dbSNP
rs771843265 256 dbSNP
rs778851029 256 dbSNP
rs1358988864 258 dbSNP
rs966714390 263 dbSNP
rs1261906343 264 dbSNP
rs1015284689 270 dbSNP
rs977303695 274 dbSNP
rs1217764327 280 dbSNP
rs954690923 283 dbSNP
rs1275947601 284 dbSNP
rs1225940527 285 dbSNP
rs1338481469 288 dbSNP
rs987337045 294 dbSNP
rs1297614112 303 dbSNP
rs1400714884 307 dbSNP
rs1347126945 314 dbSNP
rs910273182 320 dbSNP
rs1413697748 321 dbSNP
rs764859463 322 dbSNP
rs1425683125 328 dbSNP
rs185350591 339 dbSNP
rs752356115 343 dbSNP
rs1476825784 347 dbSNP
rs943138769 352 dbSNP
rs528264558 354 dbSNP
rs1478517582 355 dbSNP
rs1235377544 356 dbSNP
rs1209057671 358 dbSNP
rs548373338 361 dbSNP
rs1279829797 368 dbSNP
rs953427649 370 dbSNP
rs1206003721 371 dbSNP
rs1234255289 374 dbSNP
rs1316543235 375 dbSNP
rs987548998 376 dbSNP
rs912044645 380 dbSNP
rs772419738 386 dbSNP
rs946238224 387 dbSNP
rs1201000114 390 dbSNP
rs977633580 404 dbSNP
rs1282632838 407 dbSNP
rs1252061005 412 dbSNP
rs190443890 415 dbSNP
rs1186480662 416 dbSNP
rs746719929 416 dbSNP
rs746459887 424 dbSNP
rs74714876 425 dbSNP
rs138868113 428 dbSNP
rs1188422971 429 dbSNP
rs894848025 430 dbSNP
rs1422608912 432 dbSNP
rs1464007371 437 dbSNP
rs1172661666 439 dbSNP
rs570092224 440 dbSNP
rs1180889760 442 dbSNP
rs770569669 442 dbSNP
rs1257976017 448 dbSNP
rs397784251 448 dbSNP
rs398074940 448 dbSNP
rs572471317 448 dbSNP
rs58498573 448 dbSNP
rs906796562 448 dbSNP
rs193107688 449 dbSNP
rs906350355 451 dbSNP
rs1005094652 458 dbSNP
rs1227846955 464 dbSNP
rs1380083152 470 dbSNP
rs1317429609 478 dbSNP
rs1415582270 480 dbSNP
rs1277970553 481 dbSNP
rs1444299554 482 dbSNP
rs1338823337 485 dbSNP
rs1375949470 488 dbSNP
rs551106485 488 dbSNP
rs895185140 492 dbSNP
rs1339526965 493 dbSNP
rs1163403618 497 dbSNP
rs1405458869 510 dbSNP
rs1010935942 511 dbSNP
rs1156531645 518 dbSNP
rs751424871 520 dbSNP
rs1238008044 521 dbSNP
rs1179781831 522 dbSNP
rs757133923 530 dbSNP
rs1043827072 535 dbSNP
rs1005205384 539 dbSNP
rs999511937 543 dbSNP
rs1322471607 544 dbSNP
rs1031979854 545 dbSNP
rs1275837639 545 dbSNP
rs553383640 545 dbSNP
rs954670961 547 dbSNP
rs1309654082 548 dbSNP
rs1392952355 548 dbSNP
rs1486468728 554 dbSNP
rs114709904 561 dbSNP
rs1262220162 562 dbSNP
rs1476711281 564 dbSNP
rs1366968771 566 dbSNP
rs1295926190 567 dbSNP
rs1195846166 573 dbSNP
rs1418760543 575 dbSNP
rs781243304 580 dbSNP
rs1373544051 582 dbSNP
rs1017445948 583 dbSNP
rs1477627878 585 dbSNP
rs1170924737 586 dbSNP
rs899036483 590 dbSNP
rs1435585885 600 dbSNP
rs1214574277 603 dbSNP
rs41291261 603 dbSNP
rs1028941648 605 dbSNP
rs780553452 607 dbSNP
rs1240849418 608 dbSNP
rs1310279066 616 dbSNP
rs150261960 627 dbSNP
rs1296976298 631 dbSNP
rs1219779385 646 dbSNP
rs1346819810 647 dbSNP
rs1295754796 659 dbSNP
rs928165306 660 dbSNP
rs1360708489 662 dbSNP
rs1231663519 663 dbSNP
rs987504975 670 dbSNP
rs1349348282 677 dbSNP
rs1211231129 681 dbSNP
rs1357830262 683 dbSNP
rs1284864235 685 dbSNP
rs1481023025 687 dbSNP
rs1191514184 689 dbSNP
rs1487209762 689 dbSNP
rs1206652324 691 dbSNP
rs1477544226 691 dbSNP
rs555946219 693 dbSNP
rs775186164 693 dbSNP
rs1482134757 695 dbSNP
rs939624105 695 dbSNP
rs1262116978 701 dbSNP
rs1015299281 702 dbSNP
rs762833245 703 dbSNP
rs575770903 704 dbSNP
rs1340670976 705 dbSNP
rs1297239892 708 dbSNP
rs1397026070 711 dbSNP
rs1393978986 712 dbSNP
rs1454757405 713 dbSNP
rs1302595282 715 dbSNP
rs1470510535 715 dbSNP
rs1408867757 716 dbSNP
rs751506223 717 dbSNP
rs1465164514 718 dbSNP
rs946909089 719 dbSNP
rs544700100 722 dbSNP
rs1289854853 723 dbSNP
rs1422230470 730 dbSNP
rs926150844 739 dbSNP
rs936243350 744 dbSNP
rs1183896400 747 dbSNP
rs1462535771 749 dbSNP
rs755582342 750 dbSNP
rs184292912 762 dbSNP
rs189248208 764 dbSNP
rs1372625986 766 dbSNP
rs1242022821 768 dbSNP
rs1234344390 769 dbSNP
rs916231031 770 dbSNP
rs1308144999 771 dbSNP
rs1339445087 774 dbSNP
rs1313005999 782 dbSNP
rs1453819592 785 dbSNP
rs1351092368 787 dbSNP
rs1329867005 791 dbSNP
rs1446756826 800 dbSNP
rs1240654542 825 dbSNP
rs1261106144 826 dbSNP
rs1355359813 831 dbSNP
rs1456456553 833 dbSNP
rs999459606 833 dbSNP
rs1368052997 846 dbSNP
rs1467278483 850 dbSNP
rs1051105379 854 dbSNP
rs41291263 857 dbSNP
rs1469000043 865 dbSNP
rs543746900 866 dbSNP
rs1008809771 873 dbSNP
rs1017980588 875 dbSNP
rs1252585654 877 dbSNP
rs1207495442 882 dbSNP
rs1355109228 883 dbSNP
rs559345091 884 dbSNP
rs1292045409 886 dbSNP
rs1046110192 889 dbSNP
rs1247767817 890 dbSNP
rs906251280 897 dbSNP
rs1307464527 899 dbSNP
rs1238816330 904 dbSNP
rs1336797872 905 dbSNP
rs1331468692 906 dbSNP
rs940452837 909 dbSNP
rs994703254 913 dbSNP
rs1390162011 914 dbSNP
rs1160036296 920 dbSNP
rs749454834 924 dbSNP
rs1303964611 925 dbSNP
rs760743603 925 dbSNP
rs112779015 929 dbSNP
rs899030420 934 dbSNP
rs10795903 944 dbSNP
rs774574909 946 dbSNP
rs889047361 949 dbSNP
rs1196752948 957 dbSNP
rs927643916 958 dbSNP
rs762278756 963 dbSNP
rs1018903503 969 dbSNP
rs1446636758 972 dbSNP
rs1224099365 974 dbSNP
rs147141311 982 dbSNP
rs41291265 983 dbSNP
rs1223513655 985 dbSNP
rs991067732 995 dbSNP
rs1281752418 996 dbSNP
rs1392830758 1008 dbSNP
rs1307251662 1011 dbSNP
rs1345464634 1029 dbSNP
rs916857904 1032 dbSNP
rs561774229 1036 dbSNP
rs1358797067 1041 dbSNP
rs115965497 1053 dbSNP
rs1335427162 1055 dbSNP
rs1386916501 1055 dbSNP
rs1197862739 1059 dbSNP
rs570255456 1063 dbSNP
rs957583491 1082 dbSNP
rs761293160 1090 dbSNP
rs79085103 1091 dbSNP
rs868654816 1094 dbSNP
rs916134728 1095 dbSNP
rs1216118846 1097 dbSNP
rs1447921547 1098 dbSNP
rs891128264 1106 dbSNP
rs1286725780 1110 dbSNP
rs942721017 1117 dbSNP
rs1323369811 1121 dbSNP
rs370816362 1124 dbSNP
rs900437247 1132 dbSNP
rs994631302 1138 dbSNP
rs1255702525 1139 dbSNP
rs1431812707 1146 dbSNP
rs764771581 1151 dbSNP
rs1331905441 1155 dbSNP
rs1422490164 1168 dbSNP
rs1469103541 1170 dbSNP
rs1406652574 1175 dbSNP
rs143843020 1182 dbSNP
rs41291267 1189 dbSNP
rs886305320 1190 dbSNP
rs1476168509 1191 dbSNP
rs1004632673 1199 dbSNP
rs1185798305 1199 dbSNP
rs1465572486 1205 dbSNP
rs1461193663 1207 dbSNP
rs746358325 1210 dbSNP
rs201559144 1215 dbSNP
rs1036152020 1222 dbSNP
rs1264299733 1227 dbSNP
rs1206168762 1228 dbSNP
rs375557069 1229 dbSNP
rs772696549 1230 dbSNP
rs1352326651 1231 dbSNP
rs1463042475 1237 dbSNP
rs1298439244 1241 dbSNP
rs1282653807 1244 dbSNP
rs960388592 1245 dbSNP
rs536159151 1251 dbSNP
rs920411259 1255 dbSNP
rs1338603183 1259 dbSNP
rs1378017358 1259 dbSNP
rs1444423153 1260 dbSNP
rs930450259 1260 dbSNP
rs1170456318 1261 dbSNP
rs555817282 1263 dbSNP
rs1050240189 1264 dbSNP
rs1444363346 1279 dbSNP
rs1244183183 1287 dbSNP
rs575882815 1288 dbSNP
rs1393887987 1293 dbSNP
rs1294910223 1303 dbSNP
rs1355792358 1306 dbSNP
rs1439689403 1307 dbSNP
rs35305034 1307 dbSNP
rs1276222796 1313 dbSNP
rs1245571173 1314 dbSNP
rs1360470670 1316 dbSNP
rs1316847791 1326 dbSNP
rs1237696788 1329 dbSNP
rs1309381407 1330 dbSNP
rs558272666 1331 dbSNP
rs1298738238 1335 dbSNP
rs556889429 1338 dbSNP
rs548267129 1339 dbSNP
rs763902573 1343 dbSNP
rs1302124526 1347 dbSNP
rs924104171 1351 dbSNP
rs1008780360 1355 dbSNP
rs1040347827 1358 dbSNP
rs903224384 1359 dbSNP
rs1165786613 1363 dbSNP
rs751278205 1364 dbSNP
rs999328861 1365 dbSNP
rs1258722833 1367 dbSNP
rs1178351951 1368 dbSNP
rs1477694935 1370 dbSNP
rs1192172566 1372 dbSNP
rs1221887848 1377 dbSNP
rs1422242691 1378 dbSNP
rs942689515 1384 dbSNP
rs1033125519 1390 dbSNP
rs757032512 1391 dbSNP
rs1307582777 1392 dbSNP
rs1225444268 1398 dbSNP
rs1429575907 1399 dbSNP
rs780884802 1407 dbSNP
rs1365432734 1420 dbSNP
rs1013064348 1430 dbSNP
rs1170568695 1432 dbSNP
rs775429675 1441 dbSNP
rs1023138696 1461 dbSNP
rs578150754 1467 dbSNP
rs760743202 1468 dbSNP
rs1366988072 1472 dbSNP
rs1358007733 1477 dbSNP
rs1452070493 1478 dbSNP
rs1432494254 1479 dbSNP
rs971605618 1482 dbSNP
rs1160436327 1484 dbSNP
rs1375907809 1488 dbSNP
rs1039727660 1489 dbSNP
rs1399137231 1491 dbSNP
rs756061984 1497 dbSNP
rs11257370 1503 dbSNP
rs1364020501 1510 dbSNP
rs930536447 1528 dbSNP
rs1485410380 1530 dbSNP
rs927616854 1535 dbSNP
rs961760160 1542 dbSNP
rs1310294456 1547 dbSNP
rs972154826 1558 dbSNP
rs1346915192 1559 dbSNP
rs1275874906 1567 dbSNP
rs886254741 1574 dbSNP
rs530385621 1580 dbSNP
rs1281263473 1588 dbSNP
rs1289751144 1589 dbSNP
rs1455690247 1597 dbSNP
rs1005151791 1598 dbSNP
rs1034746209 1599 dbSNP
rs896244230 1600 dbSNP
rs560550811 1611 dbSNP
rs1428099691 1612 dbSNP
rs1486480847 1631 dbSNP
rs930399180 1656 dbSNP
rs1242446149 1658 dbSNP
rs1459858261 1658 dbSNP
rs573985004 1660 dbSNP
rs1191067253 1661 dbSNP
rs1050185502 1662 dbSNP
rs1460545234 1667 dbSNP
rs1325041568 1669 dbSNP
rs542086749 1670 dbSNP
rs1423929231 1672 dbSNP
rs1226067889 1687 dbSNP
rs1452029000 1688 dbSNP
rs1297351693 1689 dbSNP
rs1384275032 1693 dbSNP
rs1336622851 1698 dbSNP
rs910422180 1699 dbSNP
rs1175171222 1701 dbSNP
rs200306749 1702 dbSNP
rs762061987 1704 dbSNP
rs1316003396 1717 dbSNP
rs979654288 1723 dbSNP
rs944624884 1724 dbSNP
rs1373844973 1731 dbSNP
rs1040316982 1740 dbSNP
rs1172891188 1745 dbSNP
rs1442509341 1748 dbSNP
rs1292863048 1752 dbSNP
rs749438471 1754 dbSNP
rs1443162613 1757 dbSNP
rs4750127 1758 dbSNP
rs1248348002 1767 dbSNP
rs956883090 1773 dbSNP
rs1480713772 1792 dbSNP
rs998835913 1796 dbSNP
rs1252670477 1801 dbSNP
rs570782799 1809 dbSNP
rs1054881210 1810 dbSNP
rs1358317350 1812 dbSNP
rs987389129 1813 dbSNP
rs1247177273 1814 dbSNP
rs1385538949 1816 dbSNP
rs912608114 1818 dbSNP
rs1353298008 1823 dbSNP
rs1397349048 1849 dbSNP
rs781115439 1849 dbSNP
rs942784866 1856 dbSNP
rs1238157539 1858 dbSNP
rs1365218119 1861 dbSNP
rs893184703 1861 dbSNP
rs1286801675 1862 dbSNP
rs201505764 1869 dbSNP
rs867890387 1869 dbSNP
rs1446283352 1870 dbSNP
rs1221566478 1872 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaucGGAGGUACUUAAGAcuac 5'
              |||||     | ||    
Target 5' --cuCCUCC-----UCCUcccc 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000277570.5 | 3UTR | CUCCUCCUCCUCCCCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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