miRTarBase - #MIRT490584


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pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-5p
Sequence 3| UGCGGGGACAGGCCAGGGCAUC |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN13820895 3 COSMIC
COSN23388686 4 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs770355657 2 dbSNP
rs370929811 3 dbSNP
rs552910419 4 dbSNP
rs766523467 7 dbSNP
rs751761421 13 dbSNP
rs759326327 15 dbSNP
rs747312801 19 dbSNP
rs1336524397 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC47A1   
Synonyms MATE1
Description solute carrier family 47 member 1
Transcript NM_018242   
Expression
Putative miRNA Targets on SLC47A1
3'UTR of SLC47A1
(miRNA target sites are highlighted)		 
>SLC47A1|NM_018242|3'UTR
   1 CGTGGTAGGAAAGAAAGTCAGGTCAAGTGATGCTTTTGAGCTTACACACAATTCACAGGCCCACCAGTGACAATTTACTG
  81 TGAGTTAATGTCATTCAGGTGTGCCCATGGATTTTGAGGGCTGGAAATGCAAAGACACATTTTTCTATAAAAAGAAAAAG
 161 CAACTAAGGTTAAAAGCTATATTGTGGCCCAAGACACTGTCTGAAAGATGACATGAGTAGTAATTCACCACTATCTGAAC
 241 CAAGCAAGGATCAATGTGCTGACTGCATTGGCCAATGGCTTTGATACTTCTGCTATTTTTTTAGACACAAACCCATAAAC
 321 TAACTGCTTAAGAATTCATACTGCTTGAATTATGTAAAATATATTTTACAGTATATCTTTCCTTGGGCCTTAGATTACTA
 401 TTCACTGGGCAAATGGTATTTGTTTTTGTTTTAATTTTTTTTTTAATAGACGGAAGTCTTGCTCTGTCATGCAGGCTGGA
 481 GTGCGGTGGTGCGATCATAGCTCACTGCAGCCTCGAACTCTTGGGCTTCAAGCAATCCTCCTGTGTCAGCCACCAGAGTA
 561 GCTGAGACTACAGGGGTATGCCACCATGCCCAGCTGGCATTTGTTAATCTTCATTTGAGGTCTAGATCTAGGCACTGTGG
 641 ACACTGAAAAACAGTTGGGAAATCTTTCGAGCTGTGGAAATCCAAACAAAGACTGATAATTCCTGGTAGGGGTGTGTGCG
 721 TGACGTACTGCAGCCTCAACCTCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTGAGACCACAGGCGTG
 801 TGCCACCACGCCTAGCTAATTTTTTATACCAGGGTCTACCCTTTGTTTCCCAGGCTGGTCTTGAATTCCTGGGATCAAGC
 881 AATCCTTCCACCTTGCCCTCCCAAAGTGTTGGGATTATAGGCATGAGCCACCACGACTGGCCAGAGGACAAAATTTTAAT
 961 AAAGGTCTTAGCTTAAGCAGTAATCCTACTTCATTAAGCCTTCCTGGGGTGCGGTACACACCGTTAATTCAGCAACCCTC
1041 AGTACATACTAAGTATGCTCAGTGCTGTGAAAGTGGATTACACCAAATTAAGTCATTCTTATCACACCCAATCAAAAGTC
1121 AAGAAGCCAGGGATAAAAGCACCTCAGGCACATAACATTAATCTAGTAATGTAATTCTCTGCACATCCAGCTGGTGAAAC
1201 TGCGTGCTGTAAGCTGGGACCAGCTTTGTCCATAACTGCTGAGAGAACTTGCTGAAGCTCTAGGAATAATTTTGCCTGCC
1281 CGGTTGCTCACCAGTTGTAGCTTGCCAGCTCCCAACACCCTTCCTGGTGCCAATAAACTTTCTCAAAGAGCAATACTGAC
1361 ATTTCTTTTGATAAAACCTCCAGCCTTCTCTGTGTTGTTCCGACATACCGAGGACCAACTGGTCTACATGGATGCCCTGA
1441 ACATGCAATTCTTTCTTCCAAAATAAAACATTAAATAGAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuacGGGACCGGACAGGGGCGu 5'
              |:|  |||| ||:|:|: 
Target 5' aaacCTCCAGCCT-TCTCTGTg 3'
 1374 - 1394 109.00 -14.30
2 
miRNA  3' cuacgggaccggacAGGGGCGu 5'
                        ||:|:|| 
Target 5' tctagtaatgtaatTCTCTGCa 3'
 1162 - 1183 108.00 -10.50
3 
miRNA  3' cuacggGACC-GGAC--AGGGGCgu 5'
                |||| |:||  |:||:|  
Target 5' cccaggCTGGTCTTGAATTCCTGgg 3'
 849 - 873 106.00 -16.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN7161532 2 COSMIC
COSN20078973 48 COSMIC
COSN30183531 99 COSMIC
COSN28872792 222 COSMIC
COSN216756 245 COSMIC
COSN8240813 371 COSMIC
COSN29583919 445 COSMIC
COSN6100279 452 COSMIC
COSN28879592 604 COSMIC
COSN1193910 607 COSMIC
COSN24031671 623 COSMIC
COSN8832840 657 COSMIC
COSN8832841 658 COSMIC
COSN20044468 670 COSMIC
COSN16641502 726 COSMIC
COSN19729466 799 COSMIC
COSN28887177 804 COSMIC
COSN6654603 920 COSMIC
COSN23810870 1143 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374839177 2 dbSNP
rs778204666 3 dbSNP
rs1171850149 11 dbSNP
rs1411287470 13 dbSNP
rs1162341983 14 dbSNP
rs1348947482 17 dbSNP
rs550168066 22 dbSNP
rs1476990638 25 dbSNP
rs771434308 28 dbSNP
rs189455277 29 dbSNP
rs368504437 32 dbSNP
rs770373052 39 dbSNP
rs773713201 41 dbSNP
rs776113406 41 dbSNP
rs1049318180 42 dbSNP
rs761324268 49 dbSNP
rs1216404849 50 dbSNP
rs1211779177 58 dbSNP
rs1442683584 59 dbSNP
rs1363628540 61 dbSNP
rs150418147 64 dbSNP
rs1217894073 73 dbSNP
rs1004517028 80 dbSNP
rs1228341626 81 dbSNP
rs888233555 81 dbSNP
rs1348682669 99 dbSNP
rs1314885770 102 dbSNP
rs1449020344 105 dbSNP
rs866373871 110 dbSNP
rs764686081 112 dbSNP
rs1035961421 113 dbSNP
rs1261026690 119 dbSNP
rs138227262 130 dbSNP
rs1159756883 131 dbSNP
rs997206914 137 dbSNP
rs1472254203 139 dbSNP
rs1409093686 140 dbSNP
rs748373041 142 dbSNP
rs772276980 150 dbSNP
rs1183165127 161 dbSNP
rs772936172 170 dbSNP
rs992429636 174 dbSNP
rs868504010 175 dbSNP
rs766567373 178 dbSNP
rs1426632862 180 dbSNP
rs1192626969 182 dbSNP
rs953236523 185 dbSNP
rs1269214101 186 dbSNP
rs1001066178 200 dbSNP
rs34147769 201 dbSNP
rs1032266342 205 dbSNP
rs1208617437 215 dbSNP
rs956581973 216 dbSNP
rs967254230 218 dbSNP
rs1228901104 234 dbSNP
rs750070444 238 dbSNP
rs1378534679 241 dbSNP
rs1479147538 244 dbSNP
rs760494866 245 dbSNP
rs1282600279 250 dbSNP
rs1433185735 254 dbSNP
rs988829712 255 dbSNP
rs913217849 256 dbSNP
rs1405828987 264 dbSNP
rs1321029338 267 dbSNP
rs971500944 268 dbSNP
rs979024169 271 dbSNP
rs566129068 277 dbSNP
rs3187903 278 dbSNP
rs981543714 291 dbSNP
rs927494716 295 dbSNP
rs7225817 296 dbSNP
rs1412468493 297 dbSNP
rs1049662951 298 dbSNP
rs909485223 300 dbSNP
rs1382103693 302 dbSNP
rs936782366 305 dbSNP
rs1294266081 312 dbSNP
rs940926489 322 dbSNP
rs561451739 330 dbSNP
rs7504042 332 dbSNP
rs1036013664 336 dbSNP
rs1188387619 351 dbSNP
rs1463831540 354 dbSNP
rs985568778 355 dbSNP
rs568905495 376 dbSNP
rs1281043539 378 dbSNP
rs911287722 382 dbSNP
rs944036081 388 dbSNP
rs1366288533 390 dbSNP
rs575028158 390 dbSNP
rs149290701 394 dbSNP
rs1322396984 402 dbSNP
rs1434015986 404 dbSNP
rs1362776190 410 dbSNP
rs997712781 415 dbSNP
rs897435684 419 dbSNP
rs9916406 419 dbSNP
rs780561280 424 dbSNP
rs3210336 429 dbSNP
rs577039261 432 dbSNP
rs761509944 435 dbSNP
rs764878777 435 dbSNP
rs888629564 438 dbSNP
rs1214659492 441 dbSNP
rs1192261908 442 dbSNP
rs751876167 449 dbSNP
rs1207459874 452 dbSNP
rs1463919327 452 dbSNP
rs1342984562 453 dbSNP
rs750139585 454 dbSNP
rs1242193081 456 dbSNP
rs1226507594 457 dbSNP
rs1476071337 459 dbSNP
rs370685164 462 dbSNP
rs1179621818 463 dbSNP
rs1055487426 468 dbSNP
rs139394521 470 dbSNP
rs182312147 476 dbSNP
rs1386256401 480 dbSNP
rs1456635346 486 dbSNP
rs1318809872 488 dbSNP
rs1346905929 493 dbSNP
rs967738041 494 dbSNP
rs1282529164 496 dbSNP
rs1427481239 498 dbSNP
rs565191543 499 dbSNP
rs1378684511 505 dbSNP
rs36119998 515 dbSNP
rs1295490722 516 dbSNP
rs1032155104 519 dbSNP
rs1433100955 525 dbSNP
rs956633258 528 dbSNP
rs1009474864 532 dbSNP
rs1327612387 536 dbSNP
rs1208500765 539 dbSNP
rs1285500256 540 dbSNP
rs753773590 541 dbSNP
rs1207367556 552 dbSNP
rs1251206476 555 dbSNP
rs1020334201 559 dbSNP
rs1257522611 564 dbSNP
rs1484396469 564 dbSNP
rs1475321912 565 dbSNP
rs1189710286 572 dbSNP
rs1409316206 576 dbSNP
rs1472106892 577 dbSNP
rs528270707 585 dbSNP
rs1410017135 587 dbSNP
rs1412725570 591 dbSNP
rs1033306278 592 dbSNP
rs1332251310 593 dbSNP
rs981812313 594 dbSNP
rs1415627462 596 dbSNP
rs1314932285 597 dbSNP
rs1348879809 599 dbSNP
rs1228117204 600 dbSNP
rs1403981443 605 dbSNP
rs1280540714 610 dbSNP
rs1303085278 620 dbSNP
rs1465800463 621 dbSNP
rs1376319486 627 dbSNP
rs927410054 630 dbSNP
rs532403957 633 dbSNP
rs986342794 644 dbSNP
rs541662155 646 dbSNP
rs1411320580 652 dbSNP
rs911339957 653 dbSNP
rs764849060 665 dbSNP
rs976789114 666 dbSNP
rs959017837 669 dbSNP
rs1482776809 670 dbSNP
rs752254031 674 dbSNP
rs1261074807 675 dbSNP
rs868123182 683 dbSNP
rs929933483 683 dbSNP
rs984998150 683 dbSNP
rs1329851445 684 dbSNP
rs909370471 686 dbSNP
rs368728225 688 dbSNP
rs1236181724 692 dbSNP
rs1341753217 703 dbSNP
rs1300709493 707 dbSNP
rs1312943049 709 dbSNP
rs940977953 713 dbSNP
rs561402646 715 dbSNP
rs747310781 719 dbSNP
rs972286584 720 dbSNP
rs142703739 721 dbSNP
rs923486288 725 dbSNP
rs1314844307 726 dbSNP
rs933008124 731 dbSNP
rs1157340577 732 dbSNP
rs1459472679 735 dbSNP
rs145939791 736 dbSNP
rs1187075105 740 dbSNP
rs1422324679 741 dbSNP
rs895592601 743 dbSNP
rs1358380471 746 dbSNP
rs1013955113 747 dbSNP
rs1041397918 748 dbSNP
rs902854371 749 dbSNP
rs763818791 763 dbSNP
rs1203354089 770 dbSNP
rs1000228758 773 dbSNP
rs1483520311 788 dbSNP
rs888889749 790 dbSNP
rs1032944544 798 dbSNP
rs2249885 799 dbSNP
rs1380192151 831 dbSNP
rs539124093 835 dbSNP
rs541856842 837 dbSNP
rs1418918873 839 dbSNP
rs552574489 854 dbSNP
rs1316794411 858 dbSNP
rs1007423982 864 dbSNP
rs1165922211 866 dbSNP
rs1391504034 880 dbSNP
rs1162812886 885 dbSNP
rs1422962781 888 dbSNP
rs1392195238 890 dbSNP
rs1018788548 891 dbSNP
rs892296919 892 dbSNP
rs7223097 897 dbSNP
rs1161158693 898 dbSNP
rs754382715 899 dbSNP
rs1364364167 900 dbSNP
rs185515656 904 dbSNP
rs1299469104 907 dbSNP
rs1129696 920 dbSNP
rs1034743781 923 dbSNP
rs958844697 924 dbSNP
rs573490156 926 dbSNP
rs1243622171 930 dbSNP
rs985271536 933 dbSNP
rs568519816 935 dbSNP
rs1439214839 950 dbSNP
rs1332238045 954 dbSNP
rs1323496726 965 dbSNP
rs1403110209 966 dbSNP
rs1372523338 977 dbSNP
rs1308817359 984 dbSNP
rs1291133764 986 dbSNP
rs910164032 999 dbSNP
rs772327911 1004 dbSNP
rs1207364471 1013 dbSNP
rs1198636896 1014 dbSNP
rs778023974 1014 dbSNP
rs537566224 1015 dbSNP
rs1253407926 1020 dbSNP
rs373471489 1023 dbSNP
rs1041448731 1024 dbSNP
rs985838922 1031 dbSNP
rs1054511709 1033 dbSNP
rs189071914 1036 dbSNP
rs1222250614 1037 dbSNP
rs936468230 1039 dbSNP
rs62065936 1043 dbSNP
rs1308759485 1061 dbSNP
rs1409438063 1062 dbSNP
rs1352918655 1063 dbSNP
rs1007474804 1066 dbSNP
rs1384088037 1075 dbSNP
rs1402666391 1076 dbSNP
rs1175588367 1082 dbSNP
rs181507630 1121 dbSNP
rs1413524235 1127 dbSNP
rs546224280 1135 dbSNP
rs892182618 1139 dbSNP
rs1182342075 1143 dbSNP
rs1230754507 1148 dbSNP
rs1401369020 1152 dbSNP
rs552982610 1153 dbSNP
rs1262968281 1161 dbSNP
rs901680177 1171 dbSNP
rs1331932343 1180 dbSNP
rs34625647 1187 dbSNP
rs1353431684 1191 dbSNP
rs1322762751 1196 dbSNP
rs573101796 1198 dbSNP
rs1449245697 1203 dbSNP
rs993306639 1205 dbSNP
rs1025740084 1206 dbSNP
rs1340812816 1209 dbSNP
rs1046237403 1211 dbSNP
rs1468154649 1214 dbSNP
rs1390672778 1215 dbSNP
rs906473100 1219 dbSNP
rs1219534142 1220 dbSNP
rs1303329308 1221 dbSNP
rs1002516675 1227 dbSNP
rs1034386691 1233 dbSNP
rs1310367868 1238 dbSNP
rs1183220019 1239 dbSNP
rs1472947944 1242 dbSNP
rs749501887 1243 dbSNP
rs1242917374 1244 dbSNP
rs112642764 1254 dbSNP
rs984161848 1264 dbSNP
rs1458846601 1265 dbSNP
rs561565399 1267 dbSNP
rs1215727813 1273 dbSNP
rs574956934 1277 dbSNP
rs1292166245 1279 dbSNP
rs111566409 1282 dbSNP
rs564594464 1283 dbSNP
rs962072662 1288 dbSNP
rs1450107772 1294 dbSNP
rs771213819 1295 dbSNP
rs770779644 1296 dbSNP
rs1321087270 1298 dbSNP
rs1429995718 1305 dbSNP
rs386796014 1310 dbSNP
rs117319666 1311 dbSNP
rs117651256 1312 dbSNP
rs10735 1316 dbSNP
rs935748864 1320 dbSNP
rs1359321283 1326 dbSNP
rs759617838 1334 dbSNP
rs955014025 1337 dbSNP
rs1186411302 1343 dbSNP
rs1054164663 1351 dbSNP
rs1248512679 1357 dbSNP
rs188807757 1386 dbSNP
rs986780791 1400 dbSNP
rs376781353 1402 dbSNP
rs942977839 1403 dbSNP
rs1040334095 1409 dbSNP
rs528798276 1410 dbSNP
rs910258821 1411 dbSNP
rs901731066 1417 dbSNP
rs1213917628 1419 dbSNP
rs769845131 1421 dbSNP
rs1026548673 1428 dbSNP
rs957947473 1429 dbSNP
rs1364427536 1433 dbSNP
rs548772260 1437 dbSNP
rs1300877511 1444 dbSNP
rs1407824468 1446 dbSNP
rs1468095867 1447 dbSNP
rs775190877 1453 dbSNP
rs1391164104 1460 dbSNP
rs1170258527 1462 dbSNP
rs1427122135 1465 dbSNP
rs369689892 1470 dbSNP
rs762523595 1471 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuacgggaccGGACAGGGGCGu 5'
                    || |||||||| 
Target 5' ---------cCCGGUCCCCGCc 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000270570.4 | 3UTR | CCCGGUCCCCGCCGAGCUCCCCGCCGCCGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
54 hsa-miR-4749-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT062471 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT216687 F2R coagulation factor II thrombin receptor 2 2
MIRT452932 DISC1 disrupted in schizophrenia 1 2 2
MIRT457070 TOR4A torsin family 4 member A 2 2
MIRT464196 VGLL4 vestigial like family member 4 2 4
MIRT464974 TULP1 tubby like protein 1 2 6
MIRT471714 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473152 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT476086 GRB2 growth factor receptor bound protein 2 2 2
MIRT477697 EFHD2 EF-hand domain family member D2 2 2
MIRT480159 CALR calreticulin 2 2
MIRT483732 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484553 BARHL1 BarH like homeobox 1 2 6
MIRT485994 YIPF2 Yip1 domain family member 2 2 2
MIRT486530 CLCN7 chloride voltage-gated channel 7 2 2
MIRT487220 HIC1 HIC ZBTB transcriptional repressor 1 2 2
MIRT487799 GPR20 G protein-coupled receptor 20 2 4
MIRT487879 CASZ1 castor zinc finger 1 2 4
MIRT489682 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489735 GNAI2 G protein subunit alpha i2 2 4
MIRT489754 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT489841 HCFC1 host cell factor C1 2 2
MIRT490386 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490584 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490722 SLC9A3 solute carrier family 9 member A3 2 2
MIRT490741 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491705 PDZD4 PDZ domain containing 4 2 2
MIRT491743 SEMA3F semaphorin 3F 2 2
MIRT492740 PER1 period circadian clock 1 2 10
MIRT493162 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493414 KDM6B lysine demethylase 6B 2 2
MIRT493716 H2AFX H2A histone family member X 2 2
MIRT494628 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494709 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495753 PDE4C phosphodiesterase 4C 2 4
MIRT499605 ANKRD45 ankyrin repeat domain 45 2 2
MIRT501164 SLC10A7 solute carrier family 10 member 7 2 6
MIRT502116 KMT2D lysine methyltransferase 2D 2 2
MIRT502657 CTC1 CST telomere replication complex component 1 2 12
MIRT516766 FAM212B family with sequence similarity 212 member B 2 4
MIRT531190 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531975 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT569101 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569315 CC2D1B coiled-coil and C2 domain containing 1B 2 2
MIRT569535 CTTN cortactin 2 2
MIRT569851 RGS5 regulator of G protein signaling 5 2 2
MIRT570594 NFIX nuclear factor I X 2 2
MIRT608759 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT616276 HOXD11 homeobox D11 2 2
MIRT639725 RAB17 RAB17, member RAS oncogene family 2 2
MIRT661072 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT703496 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT712894 TGFA transforming growth factor alpha 2 2
MIRT721299 C3orf36 chromosome 3 open reading frame 36 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4749-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4749-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4749-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4749-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4749-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4749-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4749-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4749-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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