miRTarBase - #MIRT490733


—
pre-miRNA Information
pre-miRNA hsa-mir-4283-1   
Genomic Coordinates chr7: 56955785 - 56955864
Description Homo sapiens miR-4283-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4283-2   
Genomic Coordinates chr7: 63621090 - 63621169
Description Homo sapiens miR-4283-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4283
Sequence 11| UGGGGCUCAGCGAGUUU |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1465673533 6 dbSNP
rs1170916691 8 dbSNP
rs1318965636 9 dbSNP
rs1372440894 11 dbSNP
rs1268430213 11 dbSNP
rs1430450794 12 dbSNP
rs1480893789 12 dbSNP
rs1304625952 13 dbSNP
rs1451132774 17 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SRCIN1   
Synonyms P140, SNIP
Description SRC kinase signaling inhibitor 1
Transcript NM_025248   
Expression
Putative miRNA Targets on SRCIN1
3'UTR of SRCIN1
(miRNA target sites are highlighted)		 
>SRCIN1|NM_025248|3'UTR
   1 AAGCCCCTCACCCCGCTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCACCCC
  81 ACCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCAT
 161 CATCTGTTGGTGTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAA
 241 CTAAAAACCAAACACACCACCTTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCT
 321 TTCACCACTCTTTCCCCCAGTCCATCCTGAAGCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCCCAAGAATACTCCA
 401 AACAAACTCTGAACCACGGAGACTTGGAGCAGTGGGAGACCCCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGCGGG
 481 GACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGGAGACTGGCCTTGGAGATGCCCCACTCCCTGTCTA
 561 AGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACACCCAAGTGGGCCTGGAGTAGAGACG
 641 GACAGGCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTATCCCTGGGGAGGCG
 721 CTGGCCTCCTGGGCCTTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGGTTGC
 801 ACGGACAGCCGGATATCGGGGACACTGCCTTGGGAGAGGGCGGCCCGGACGGGTATTTGGTACTTTTAGTTTCCTGATTT
 881 AGCACTTTAAATGGCATTAACTTATTGAATGGGGATGGGGTGGGCAAGAGTGAGGGGCCTAGAAAACCAGGTTTTGTGGC
 961 TTGCAGTTGGGGGAAGGGTCTGGTTTGAGGGAAATGGGAGGGTCGAGAGGGGCTTGACGGGGAGCACTGAAGACACCTGG
1041 GACCCGCAGGTGGGGTGACTTGAACTTCAGTCATCCTCTTGGCAATTTGAGGGTTTTCCCAGGAAAGGATGAGACGTAGT
1121 TTTTCAATGGGGCTCTGGTGACCCTGGTGAGATGTCTGAAGGTCCCTGAGGCCTGACCATCCAGCCAGCGCCCCTGGCCT
1201 GTGGACGCCCTGCCTGCCCTGCAGAGGCGGTTGGCAGTGCCGCCTGGCTTTTGGCCGGGTCCTGGGGAGGCAGAGAGAGG
1281 CCAATTTTGGTTCTCACTCCTGGCCCCCCAGAGGGCACAGTGAGGAGCCGGTAGGGAGAGGATAGGAGAAGAGGAGGAGG
1361 AGGAGCGGGGTCCCCGGCCGCAGGATTCCCACTTGGAGCACAAAGTGAAGTAAGCACAGGGGAGGGGGACTAGAATCAGT
1441 CCCCCATAGCAAGCACAGAAAGGAGGAGCTGCGCAGAAGGCAGAGCCCCCCAGACCCTGGGGCCTGGCTGGGGAAGGTCC
1521 GCACCTGGGGAGAGCTGGGAGCTGTTGAAGGTTTGGGGGGAGGGGAAACGGGTTGTGTTTCTTCATTTCTTTTTTTGTTT
1601 TTGCCTTTGTTGGTTCATCCTTGTTTTCTAGCTTTGGATCATTTTTGTACCAAGGCGAGCAAGCCTTTTTGAAAAATAAC
1681 AAAAGAGGAAAAAAAAAATCCCTCCTGGAAAAAAAAAAAAACCCTGGAAAATAGAAAAAAAAAAAAGGACCTCATAAATG
1761 ATGCAATTACTTTTAATTGCAGGCAACTCTTTACATTTAAGTGAAGTGTCTTAACATTTTATATTGTTTTAAAAATATAT
1841 TTACATATTATATATATAATATACGTAATATAAATATATATAAATATTTAAAAAAGAAAAAAAAAAGAAAACCACGGCAC
1921 TCTCCCTGGCCACTGTTTTGGCGGGGGAGGGGGGCTGGGGGGCGGGCACGTCGGCCTGGCTTCTGTGGTCCCAGTGAAAT
2001 GGTCTGGTTTGATTTGGCTGTACAGAGACCCCCTGACTTGGGAGGGGAGGGGGGAGTGGTGCCCCCTCCTCCCTCCACTC
2081 CATTACTCTCTGCTTGCTACTTCGCTTGCCCCCAGCTCCCACCCTCAGCCCTGTGACTGGAATGTGTGCCCCACCGTCAT
2161 TGTCCTGAGTTGAATGTCCCTTTGTGGGGGAGGTGGGGGGGGCAGTGTCCATCCACGAAGGGGCAGAAGGAGGGAGCCAC
2241 GTGCCCCGCCCCACCCGCTCGGGTGAAGCCCAGTGGGATTTGCATCTTTCTTTCTCTTTGGTTCCTGCACATTTATGGGC
2321 TGGGAGGCATCCGTGTGGAATTGCGTGCAGCCTGTGTGTGTGCTGGCACAAGCCCATGCACTGTGTGTGCAGACGCATGG
2401 GGCCTGCACCCACAGGCATGGCCGAGCACATGTGTGGGGGAAGGCGTGGGCACATAGGTGCATGTAACCTGTTTGGGCAT
2481 TGGCACGTGCCTACCTGCATGTTAGCGTGAGAGGAGCTTTGTGTGTGAGAACATGTGTAATGTGTGTGCAGACATGCCGA
2561 GAGCCAGAGACTTGTGTGTGGGCCACGTACATGTGGATAGAGACGCATACATGGAGGTGCATGTAATCTGTGTCTCCGAG
2641 TGTGTGTGTGCAGGTATGTGTGCTGGTGCAGACCCAAGTGTGTGGGTGTGCCTCTGTGTGCGTGTGTTCCATCATCCCTG
2721 CACCACTGGCTCCAGATCCCTTCCTGAGCCCCCGTCCCCGCTGGCCCTCTCACAGCCTGCAGCACATCAGTGCCCCCAGC
2801 TGCATGCGCCTCGCTGCTCTGTCCATCAGTGTGTGCTTGACCAAGAGAAAACTAAGACGTCTCGGGGGACCCCTGTACCT
2881 GGTCCTCTCAGCCCCCGCCCACTGTGCTGTGTTACTCGCATGGGGGATTTCCTGCCCCTTCCACAATATGCTGTTTCCCC
2961 AGGAGCCTCAGGCCTGAGGCTCTGAGTGGGGTCCCCAGGGGGCCCCCCGGGGTGAGCCCCGGCTCCACACCCTGCCCCAT
3041 CCACCCTGTAGGGCCCATGTTGGTGTAGCAGTGATGGCTTCTGTGGATATTCTGTGACCTCTGTCGGTGTAACTTGACAA
3121 TTTCTAAATGGAAAAGGGTTGCTGTGTTTTCTCTGTCTCTCTTTTTTAATGTCCTTTTTTCTTCTCCCCCGCTCCCTGCT
3201 CTCTTTCCTTTTCAGTTTTTCTAGCCAAGTGTTTGGGGCTTTAATAAAACTTGTTTCTTTTTCCTCTCCTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuGAGCGACUCGGGGu 5'
             ||: ||||||||| 
Target 5' tccCTTCCTGAGCCCCc 3'
 2737 - 2753 158.00 -18.70
2 
miRNA  3' uuugagCGACUCGGGGu 5'
                || ||||||| 
Target 5' cagaagGCAGAGCCCCc 3'
 1474 - 1490 147.00 -14.50
3 
miRNA  3' uuugagCGACUCGGGGu 5'
                | |||||||| 
Target 5' ccccggGGTGAGCCCCg 3'
 3005 - 3021 147.00 -18.40
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs532827232 6 dbSNP
rs1239758947 7 dbSNP
rs767726066 10 dbSNP
rs961250412 14 dbSNP
rs370292461 15 dbSNP
rs1369627649 21 dbSNP
rs111650340 22 dbSNP
rs763225349 23 dbSNP
rs1386068809 24 dbSNP
rs1237888484 26 dbSNP
rs775771060 29 dbSNP
rs1015500391 30 dbSNP
rs1386074092 33 dbSNP
rs1381722228 34 dbSNP
rs560770382 35 dbSNP
rs200028328 37 dbSNP
rs1395006160 40 dbSNP
rs746396634 41 dbSNP
rs897626814 49 dbSNP
rs1341488572 58 dbSNP
rs1446457410 60 dbSNP
rs1326183614 61 dbSNP
rs1439499696 65 dbSNP
rs1307364315 66 dbSNP
rs1005655669 70 dbSNP
rs1347676390 74 dbSNP
rs1342926509 76 dbSNP
rs1322106025 77 dbSNP
rs1202143582 81 dbSNP
rs967284799 84 dbSNP
rs1457168917 86 dbSNP
rs1176486516 89 dbSNP
rs1420881856 90 dbSNP
rs1440000755 91 dbSNP
rs1197715008 92 dbSNP
rs1375477976 96 dbSNP
rs1021587775 101 dbSNP
rs1407419493 102 dbSNP
rs1011402381 111 dbSNP
rs894288788 112 dbSNP
rs888119258 113 dbSNP
rs35779101 114 dbSNP
rs1245097507 126 dbSNP
rs527322328 130 dbSNP
rs1003002881 135 dbSNP
rs1300807200 138 dbSNP
rs906953528 142 dbSNP
rs1314839230 145 dbSNP
rs1275378887 147 dbSNP
rs73982819 148 dbSNP
rs73982818 149 dbSNP
rs1040538329 150 dbSNP
rs34205353 150 dbSNP
rs1434423470 155 dbSNP
rs1349854968 172 dbSNP
rs1291750296 178 dbSNP
rs1444231525 179 dbSNP
rs1233158540 180 dbSNP
rs1169134578 183 dbSNP
rs1477813557 183 dbSNP
rs55845463 184 dbSNP
rs944953147 184 dbSNP
rs9901664 184 dbSNP
rs1388769971 185 dbSNP
rs374878561 185 dbSNP
rs71842892 185 dbSNP
rs1284081380 186 dbSNP
rs1491049718 186 dbSNP
rs1339924218 187 dbSNP
rs1216778472 188 dbSNP
rs1179808033 189 dbSNP
rs1279982759 189 dbSNP
rs530217237 189 dbSNP
rs1487004244 190 dbSNP
rs567994827 190 dbSNP
rs1257871986 191 dbSNP
rs946745269 191 dbSNP
rs1280741857 192 dbSNP
rs1303964788 192 dbSNP
rs1459695859 192 dbSNP
rs1362503358 193 dbSNP
rs1189425238 194 dbSNP
rs1395376635 194 dbSNP
rs558932451 195 dbSNP
rs1323262348 198 dbSNP
rs1170016651 202 dbSNP
rs1181783128 202 dbSNP
rs1245117339 202 dbSNP
rs549091639 202 dbSNP
rs79154508 202 dbSNP
rs1442344607 203 dbSNP
rs887472944 204 dbSNP
rs1425896972 207 dbSNP
rs1164485576 212 dbSNP
rs1379868347 213 dbSNP
rs1307978972 216 dbSNP
rs1417955351 216 dbSNP
rs796158632 218 dbSNP
rs545612905 221 dbSNP
rs1045110634 222 dbSNP
rs1160464148 230 dbSNP
rs1345846511 238 dbSNP
rs1377721275 242 dbSNP
rs1300978239 249 dbSNP
rs1174464302 253 dbSNP
rs1055621562 264 dbSNP
rs940393583 265 dbSNP
rs887346266 266 dbSNP
rs1432870942 275 dbSNP
rs1308092205 276 dbSNP
rs1048648621 281 dbSNP
rs576689403 285 dbSNP
rs367783162 286 dbSNP
rs921405215 287 dbSNP
rs183115144 292 dbSNP
rs374111642 293 dbSNP
rs981941994 295 dbSNP
rs961178921 298 dbSNP
rs56153173 300 dbSNP
rs1184532642 303 dbSNP
rs55974793 304 dbSNP
rs563007325 306 dbSNP
rs952489922 307 dbSNP
rs56395428 312 dbSNP
rs1470126131 319 dbSNP
rs996615487 319 dbSNP
rs1310037925 320 dbSNP
rs1285925547 325 dbSNP
rs1397835769 330 dbSNP
rs1448600758 332 dbSNP
rs1279742493 333 dbSNP
rs1223801473 334 dbSNP
rs1366332845 346 dbSNP
rs1216923052 347 dbSNP
rs1372058888 348 dbSNP
rs1299838953 359 dbSNP
rs1326196964 361 dbSNP
rs965095974 362 dbSNP
rs776686305 363 dbSNP
rs771022416 364 dbSNP
rs990036281 365 dbSNP
rs1019361331 366 dbSNP
rs958656476 368 dbSNP
rs569275334 370 dbSNP
rs552758227 371 dbSNP
rs1427346338 377 dbSNP
rs1357736309 378 dbSNP
rs1313817673 398 dbSNP
rs1397897144 398 dbSNP
rs902677595 404 dbSNP
rs539244044 407 dbSNP
rs1348884285 408 dbSNP
rs1433685221 413 dbSNP
rs1294847675 418 dbSNP
rs1345567541 421 dbSNP
rs1034557406 438 dbSNP
rs1043041604 443 dbSNP
rs1002748321 449 dbSNP
rs906936660 450 dbSNP
rs567161352 457 dbSNP
rs1219627600 466 dbSNP
rs1271205260 467 dbSNP
rs879300216 475 dbSNP
rs1192896026 476 dbSNP
rs370912134 477 dbSNP
rs938002570 478 dbSNP
rs1168219318 480 dbSNP
rs887422747 483 dbSNP
rs547362448 487 dbSNP
rs1403308153 491 dbSNP
rs1166430147 495 dbSNP
rs1476116654 503 dbSNP
rs62075667 513 dbSNP
rs900087574 515 dbSNP
rs190846259 516 dbSNP
rs547890157 523 dbSNP
rs1433497944 527 dbSNP
rs1271195993 532 dbSNP
rs1356061883 539 dbSNP
rs1226863223 540 dbSNP
rs912625781 540 dbSNP
rs1294173484 542 dbSNP
rs1360285713 552 dbSNP
rs1215912086 553 dbSNP
rs531405183 555 dbSNP
rs1448736525 557 dbSNP
rs111854159 563 dbSNP
rs914542283 566 dbSNP
rs781776219 567 dbSNP
rs952633831 572 dbSNP
rs958869431 582 dbSNP
rs1418565982 591 dbSNP
rs927264411 592 dbSNP
rs1156375116 594 dbSNP
rs1327833602 600 dbSNP
rs981666687 601 dbSNP
rs562255414 612 dbSNP
rs975104942 615 dbSNP
rs971277606 617 dbSNP
rs545586556 620 dbSNP
rs1317444179 625 dbSNP
rs1019412631 626 dbSNP
rs1239694292 630 dbSNP
rs1004561387 639 dbSNP
rs951807705 640 dbSNP
rs1027239967 647 dbSNP
rs1377520985 649 dbSNP
rs995897907 654 dbSNP
rs1431806970 655 dbSNP
rs751826696 660 dbSNP
rs185993294 661 dbSNP
rs1438757681 662 dbSNP
rs1039985161 664 dbSNP
rs1365073335 666 dbSNP
rs1044451308 672 dbSNP
rs1418417336 675 dbSNP
rs1159679246 682 dbSNP
rs1164072451 685 dbSNP
rs559994360 689 dbSNP
rs1421833131 694 dbSNP
rs891272358 696 dbSNP
rs114322800 720 dbSNP
rs1186721811 731 dbSNP
rs574661182 732 dbSNP
rs938867437 733 dbSNP
rs946073981 734 dbSNP
rs914698455 737 dbSNP
rs1046470773 738 dbSNP
rs940067847 739 dbSNP
rs756802603 740 dbSNP
rs1214950146 741 dbSNP
rs554921588 758 dbSNP
rs560252508 763 dbSNP
rs937385076 767 dbSNP
rs1048195158 772 dbSNP
rs931126816 776 dbSNP
rs921214183 784 dbSNP
rs1437918955 785 dbSNP
rs1197466886 789 dbSNP
rs1375428823 795 dbSNP
rs537855101 797 dbSNP
rs975323622 802 dbSNP
rs943718727 803 dbSNP
rs1244747289 810 dbSNP
rs927182202 811 dbSNP
rs981356663 818 dbSNP
rs971734719 827 dbSNP
rs753492362 829 dbSNP
rs912193279 832 dbSNP
rs1229639294 841 dbSNP
rs1329394923 842 dbSNP
rs774394678 846 dbSNP
rs575768555 847 dbSNP
rs1317093533 850 dbSNP
rs983253171 851 dbSNP
rs1216509470 853 dbSNP
rs143283531 855 dbSNP
rs1027396035 860 dbSNP
rs149600710 868 dbSNP
rs964433133 870 dbSNP
rs989690150 883 dbSNP
rs1019046048 884 dbSNP
rs1292841109 885 dbSNP
rs182249580 887 dbSNP
rs1002378836 894 dbSNP
rs1168856808 896 dbSNP
rs1375126970 902 dbSNP
rs1170835067 915 dbSNP
rs891385995 915 dbSNP
rs1041905712 917 dbSNP
rs1462732039 935 dbSNP
rs1448657624 937 dbSNP
rs553685011 938 dbSNP
rs1387921691 951 dbSNP
rs1195183970 956 dbSNP
rs1010443047 969 dbSNP
rs879085114 973 dbSNP
rs924760199 974 dbSNP
rs116625090 978 dbSNP
rs977558237 979 dbSNP
rs1406797340 982 dbSNP
rs1024907325 991 dbSNP
rs1266108173 996 dbSNP
rs567884738 1002 dbSNP
rs1339678719 1004 dbSNP
rs1054567899 1005 dbSNP
rs937439411 1006 dbSNP
rs1487767276 1010 dbSNP
rs887226195 1012 dbSNP
rs927285791 1013 dbSNP
rs1243666794 1018 dbSNP
rs1263278180 1023 dbSNP
rs1360987794 1025 dbSNP
rs1222494858 1026 dbSNP
rs559549483 1027 dbSNP
rs1284674775 1028 dbSNP
rs1488281422 1034 dbSNP
rs548119455 1045 dbSNP
rs1264346295 1046 dbSNP
rs1429440428 1047 dbSNP
rs1187133648 1052 dbSNP
rs531252703 1053 dbSNP
rs1426633445 1054 dbSNP
rs1164369697 1059 dbSNP
rs1341972345 1062 dbSNP
rs1359965832 1070 dbSNP
rs899658956 1077 dbSNP
rs1290530903 1085 dbSNP
rs1039650135 1102 dbSNP
rs1236824263 1106 dbSNP
rs943913640 1116 dbSNP
rs568611416 1126 dbSNP
rs551883884 1127 dbSNP
rs977114871 1150 dbSNP
rs555298183 1152 dbSNP
rs945688077 1172 dbSNP
rs914369073 1179 dbSNP
rs1298734556 1186 dbSNP
rs1428861089 1189 dbSNP
rs990301382 1190 dbSNP
rs544829994 1191 dbSNP
rs1262963280 1196 dbSNP
rs559882354 1206 dbSNP
rs981005483 1207 dbSNP
rs1446733925 1210 dbSNP
rs970923611 1213 dbSNP
rs1025166403 1218 dbSNP
rs1161233127 1223 dbSNP
rs540077389 1226 dbSNP
rs1004239601 1229 dbSNP
rs887104582 1239 dbSNP
rs1027104876 1241 dbSNP
rs995962079 1242 dbSNP
rs899686664 1256 dbSNP
rs1039528837 1257 dbSNP
rs368596080 1280 dbSNP
rs527493845 1280 dbSNP
rs1183623908 1281 dbSNP
rs35045916 1289 dbSNP
rs891073040 1296 dbSNP
rs1456558382 1297 dbSNP
rs575862553 1300 dbSNP
rs1482917881 1302 dbSNP
rs1272995360 1303 dbSNP
rs1204588239 1304 dbSNP
rs1042024944 1308 dbSNP
rs1345929849 1309 dbSNP
rs1255634390 1310 dbSNP
rs945766935 1314 dbSNP
rs1408786676 1321 dbSNP
rs1432567275 1328 dbSNP
rs529954742 1329 dbSNP
rs556247381 1330 dbSNP
rs1288876098 1340 dbSNP
rs1054216735 1345 dbSNP
rs1352340191 1349 dbSNP
rs937061123 1349 dbSNP
rs1348576870 1359 dbSNP
rs1326133702 1366 dbSNP
rs869063461 1366 dbSNP
rs926804215 1366 dbSNP
rs970849455 1366 dbSNP
rs980933363 1366 dbSNP
rs1224446956 1367 dbSNP
rs1314439764 1375 dbSNP
rs775583094 1376 dbSNP
rs1400973733 1379 dbSNP
rs1490195389 1380 dbSNP
rs1265659561 1388 dbSNP
rs1197217317 1390 dbSNP
rs983430573 1391 dbSNP
rs951420514 1392 dbSNP
rs1169780162 1398 dbSNP
rs1417112881 1402 dbSNP
rs1027361688 1403 dbSNP
rs995618467 1410 dbSNP
rs964152664 1411 dbSNP
rs544584894 1412 dbSNP
rs1347869584 1419 dbSNP
rs1183510802 1421 dbSNP
rs1008104169 1424 dbSNP
rs1472523270 1427 dbSNP
rs1250288376 1428 dbSNP
rs1190434111 1430 dbSNP
rs1270027006 1432 dbSNP
rs144814237 1433 dbSNP
rs1041646105 1441 dbSNP
rs1273916230 1442 dbSNP
rs1198986987 1443 dbSNP
rs1358834212 1447 dbSNP
rs1220263458 1448 dbSNP
rs1352905616 1456 dbSNP
rs1294037071 1459 dbSNP
rs559071402 1466 dbSNP
rs1054498825 1469 dbSNP
rs936994713 1470 dbSNP
rs927068328 1473 dbSNP
rs545552121 1479 dbSNP
rs573388924 1484 dbSNP
rs1422223695 1487 dbSNP
rs190998309 1491 dbSNP
rs1365631645 1492 dbSNP
rs1295063720 1493 dbSNP
rs1318199179 1508 dbSNP
rs1325071376 1508 dbSNP
rs1448467391 1512 dbSNP
rs949588240 1520 dbSNP
rs536446830 1521 dbSNP
rs1382393951 1522 dbSNP
rs1244038945 1524 dbSNP
rs1383615349 1525 dbSNP
rs567942224 1527 dbSNP
rs557418985 1530 dbSNP
rs1360219952 1532 dbSNP
rs1204517277 1537 dbSNP
rs1282007446 1548 dbSNP
rs770988979 1549 dbSNP
rs983056287 1555 dbSNP
rs375895405 1556 dbSNP
rs1185014778 1557 dbSNP
rs568549163 1560 dbSNP
rs1469136207 1561 dbSNP
rs560338375 1561 dbSNP
rs1473312056 1563 dbSNP
rs1402948272 1564 dbSNP
rs1319461914 1566 dbSNP
rs964038645 1569 dbSNP
rs1018406093 1570 dbSNP
rs1450780011 1584 dbSNP
rs1338900258 1592 dbSNP
rs1383652797 1593 dbSNP
rs1238349673 1596 dbSNP
rs1368302680 1597 dbSNP
rs1277712519 1603 dbSNP
rs1008283955 1608 dbSNP
rs955197492 1609 dbSNP
rs551772191 1612 dbSNP
rs1262315545 1621 dbSNP
rs3990045 1623 dbSNP
rs1459779988 1641 dbSNP
rs1448912358 1652 dbSNP
rs1205196517 1657 dbSNP
rs1243309898 1664 dbSNP
rs1436725753 1665 dbSNP
rs1248882986 1671 dbSNP
rs1208117699 1677 dbSNP
rs1463642782 1680 dbSNP
rs1160514748 1685 dbSNP
rs1429067799 1685 dbSNP
rs539128839 1685 dbSNP
rs570513623 1687 dbSNP
rs1355354195 1688 dbSNP
rs1407027607 1690 dbSNP
rs1391039154 1694 dbSNP
rs1327004061 1699 dbSNP
rs551349351 1699 dbSNP
rs553518573 1699 dbSNP
rs533544028 1703 dbSNP
rs1229380614 1705 dbSNP
rs1365389274 1706 dbSNP
rs1225046590 1708 dbSNP
rs1020516201 1718 dbSNP
rs532051113 1719 dbSNP
rs1193695176 1720 dbSNP
rs893069861 1721 dbSNP
rs1183566126 1722 dbSNP
rs1268732941 1722 dbSNP
rs1487136479 1722 dbSNP
rs1479665439 1725 dbSNP
rs1179121853 1732 dbSNP
rs1396080264 1732 dbSNP
rs568057272 1734 dbSNP
rs1406410031 1735 dbSNP
rs1398751886 1740 dbSNP
rs1413740860 1741 dbSNP
rs1246793043 1747 dbSNP
rs1343633497 1747 dbSNP
rs1032908802 1749 dbSNP
rs1283743155 1786 dbSNP
rs1325609352 1809 dbSNP
rs1001193355 1816 dbSNP
rs1161751631 1825 dbSNP
rs905528296 1839 dbSNP
rs1221003399 1850 dbSNP
rs1045463347 1859 dbSNP
rs1451731447 1859 dbSNP
rs1202204335 1864 dbSNP
rs949765173 1865 dbSNP
rs1391002665 1871 dbSNP
rs1428235218 1879 dbSNP
rs1188244904 1889 dbSNP
rs896670313 1890 dbSNP
rs1255020239 1896 dbSNP
rs1163073055 1902 dbSNP
rs1208663999 1907 dbSNP
rs1294001106 1907 dbSNP
rs1363765637 1907 dbSNP
rs1222437614 1909 dbSNP
rs1047707844 1911 dbSNP
rs1380256315 1911 dbSNP
rs1297285006 1912 dbSNP
rs1365564027 1912 dbSNP
rs930141818 1913 dbSNP
rs1312348577 1915 dbSNP
rs566233028 1916 dbSNP
rs1225391416 1917 dbSNP
rs546734488 1922 dbSNP
rs974314936 1931 dbSNP
rs1485747437 1933 dbSNP
rs1203823110 1935 dbSNP
rs1264282368 1939 dbSNP
rs1197275267 1942 dbSNP
rs1342684134 1943 dbSNP
rs1296374254 1946 dbSNP
rs969195821 1948 dbSNP
rs1165415365 1949 dbSNP
rs1225784352 1953 dbSNP
rs1451543160 1954 dbSNP
rs1290476648 1956 dbSNP
rs942687039 1957 dbSNP
rs1451519995 1961 dbSNP
rs1334226213 1963 dbSNP
rs1384377293 1963 dbSNP
rs1372752615 1967 dbSNP
rs911189330 1969 dbSNP
rs9783843 1970 dbSNP
rs1349748790 1972 dbSNP
rs1262908400 1973 dbSNP
rs1465598476 1979 dbSNP
rs1203300401 1988 dbSNP
rs955612206 1993 dbSNP
rs1335826186 1998 dbSNP
rs1021663034 2003 dbSNP
rs1182591197 2004 dbSNP
rs1249897107 2006 dbSNP
rs1417300406 2014 dbSNP
rs1161168714 2017 dbSNP
rs1020353010 2026 dbSNP
rs1469044869 2030 dbSNP
rs989072902 2034 dbSNP
rs1322207156 2037 dbSNP
rs957223533 2046 dbSNP
rs1033375149 2049 dbSNP
rs1001371156 2055 dbSNP
rs1371604826 2055 dbSNP
rs1168177611 2056 dbSNP
rs1428014786 2061 dbSNP
rs1290702329 2062 dbSNP
rs1330260046 2067 dbSNP
rs1261657997 2068 dbSNP
rs1427570577 2073 dbSNP
rs1211063301 2074 dbSNP
rs1232418054 2076 dbSNP
rs1191774721 2077 dbSNP
rs905538468 2078 dbSNP
rs1244898928 2082 dbSNP
rs1023901057 2085 dbSNP
rs529888402 2095 dbSNP
rs1013862454 2099 dbSNP
rs886211202 2103 dbSNP
rs1414721846 2104 dbSNP
rs1047472043 2111 dbSNP
rs1352284065 2119 dbSNP
rs1463021123 2155 dbSNP
rs930170873 2156 dbSNP
rs561233071 2161 dbSNP
rs898631232 2166 dbSNP
rs1202799998 2168 dbSNP
rs1038637400 2179 dbSNP
rs1281832819 2180 dbSNP
rs1370145464 2186 dbSNP
rs1272481160 2195 dbSNP
rs942909432 2195 dbSNP
rs1349515305 2196 dbSNP
rs1275424983 2198 dbSNP
rs1490178303 2200 dbSNP
rs533263281 2203 dbSNP
rs911241680 2203 dbSNP
rs1478210459 2208 dbSNP
rs544207234 2209 dbSNP
rs749831752 2211 dbSNP
rs548038259 2217 dbSNP
rs3913867 2222 dbSNP
rs1218112063 2240 dbSNP
rs531404082 2241 dbSNP
rs1912410 2242 dbSNP
rs1424636110 2245 dbSNP
rs1912411 2247 dbSNP
rs565244018 2248 dbSNP
rs545437932 2251 dbSNP
rs1437565359 2253 dbSNP
rs957439892 2254 dbSNP
rs1351674871 2256 dbSNP
rs566705254 2260 dbSNP
rs186274764 2261 dbSNP
rs1358758053 2269 dbSNP
rs1220204087 2272 dbSNP
rs980006254 2276 dbSNP
rs1214879440 2284 dbSNP
rs1240138140 2296 dbSNP
rs1408392424 2298 dbSNP
rs562439411 2300 dbSNP
rs1361054350 2315 dbSNP
rs553197489 2327 dbSNP
rs1384092492 2331 dbSNP
rs150379257 2332 dbSNP
rs574183353 2344 dbSNP
rs1416665094 2345 dbSNP
rs1406460288 2348 dbSNP
rs868561438 2351 dbSNP
rs557619641 2379 dbSNP
rs1413975025 2383 dbSNP
rs756489050 2387 dbSNP
rs1321419680 2390 dbSNP
rs752997526 2390 dbSNP
rs1382133563 2394 dbSNP
rs114055727 2395 dbSNP
rs1223111842 2400 dbSNP
rs1281943179 2404 dbSNP
rs1330882746 2405 dbSNP
rs1208995985 2414 dbSNP
rs1472854304 2424 dbSNP
rs1250994196 2425 dbSNP
rs1179670916 2427 dbSNP
rs1242067126 2428 dbSNP
rs1484143462 2432 dbSNP
rs867471601 2433 dbSNP
rs1237523219 2434 dbSNP
rs1473442146 2435 dbSNP
rs558084910 2436 dbSNP
rs1237688173 2445 dbSNP
rs181601694 2446 dbSNP
rs1309914632 2451 dbSNP
rs1160199629 2453 dbSNP
rs1285691583 2462 dbSNP
rs1228508398 2468 dbSNP
rs1038521613 2473 dbSNP
rs1179514027 2476 dbSNP
rs1288285400 2481 dbSNP
rs1408375279 2486 dbSNP
rs1007047797 2487 dbSNP
rs566553631 2488 dbSNP
rs1441415973 2489 dbSNP
rs369359455 2492 dbSNP
rs9903055 2493 dbSNP
rs1228843717 2494 dbSNP
rs1321026076 2495 dbSNP
rs567382497 2507 dbSNP
rs371012140 2515 dbSNP
rs12600454 2517 dbSNP
rs1473850325 2524 dbSNP
rs1183437010 2527 dbSNP
rs1428988522 2532 dbSNP
rs1464774961 2535 dbSNP
rs925802431 2537 dbSNP
rs979929564 2540 dbSNP
rs1409379577 2548 dbSNP
rs1326780042 2553 dbSNP
rs1352338555 2558 dbSNP
rs1411124513 2559 dbSNP
rs530795869 2572 dbSNP
rs1282456501 2574 dbSNP
rs1343360319 2574 dbSNP
rs565179354 2578 dbSNP
rs1235003858 2580 dbSNP
rs917199311 2584 dbSNP
rs1425300220 2586 dbSNP
rs1338199025 2587 dbSNP
rs986535801 2588 dbSNP
rs1193633256 2591 dbSNP
rs1414323489 2595 dbSNP
rs1276150566 2598 dbSNP
rs1181093249 2599 dbSNP
rs992726082 2604 dbSNP
rs145526517 2605 dbSNP
rs1025957870 2610 dbSNP
rs528545463 2611 dbSNP
rs1208750013 2623 dbSNP
rs879082405 2628 dbSNP
rs1166840860 2630 dbSNP
rs963154723 2633 dbSNP
rs1430361516 2634 dbSNP
rs868006055 2637 dbSNP
rs9912504 2638 dbSNP
rs1197445704 2640 dbSNP
rs1268050309 2641 dbSNP
rs1237580149 2650 dbSNP
rs1299236455 2651 dbSNP
rs1342189673 2651 dbSNP
rs1324048791 2653 dbSNP
rs1295090197 2654 dbSNP
rs1313829228 2658 dbSNP
rs1291603298 2664 dbSNP
rs889949138 2674 dbSNP
rs1051352928 2676 dbSNP
rs1268461563 2692 dbSNP
rs1446692360 2693 dbSNP
rs1186858715 2698 dbSNP
rs1392140853 2700 dbSNP
rs998408566 2701 dbSNP
rs891808849 2702 dbSNP
rs1459377220 2704 dbSNP
rs1293934916 2706 dbSNP
rs1383940677 2708 dbSNP
rs1432475192 2717 dbSNP
rs147525025 2746 dbSNP
rs935986743 2749 dbSNP
rs1451201285 2750 dbSNP
rs926079080 2753 dbSNP
rs1388048770 2754 dbSNP
rs1247605568 2758 dbSNP
rs763203641 2759 dbSNP
rs1459336000 2760 dbSNP
rs1207064496 2766 dbSNP
rs1250073395 2767 dbSNP
rs1367603655 2769 dbSNP
rs1465503486 2771 dbSNP
rs1350432296 2782 dbSNP
rs1254132078 2785 dbSNP
rs1044451910 2789 dbSNP
rs917042314 2790 dbSNP
rs1455382467 2794 dbSNP
rs75746632 2797 dbSNP
rs1160940069 2802 dbSNP
rs993173278 2804 dbSNP
rs563704361 2807 dbSNP
rs1300623636 2808 dbSNP
rs139690578 2812 dbSNP
rs1398341110 2813 dbSNP
rs919156958 2819 dbSNP
rs1350271854 2825 dbSNP
rs1227007893 2829 dbSNP
rs1391621982 2832 dbSNP
rs973114119 2834 dbSNP
rs1188885144 2836 dbSNP
rs1254357684 2840 dbSNP
rs963035232 2841 dbSNP
rs1448320633 2847 dbSNP
rs1249658316 2852 dbSNP
rs1471559530 2854 dbSNP
rs150622272 2858 dbSNP
rs1412412658 2859 dbSNP
rs558070925 2863 dbSNP
rs1211140795 2864 dbSNP
rs1360396403 2867 dbSNP
rs115753348 2868 dbSNP
rs1466054457 2869 dbSNP
rs1266556073 2872 dbSNP
rs985841873 2878 dbSNP
rs753859593 2887 dbSNP
rs1290649457 2890 dbSNP
rs188899344 2890 dbSNP
rs1029807052 2896 dbSNP
rs572777885 2897 dbSNP
rs866042811 2902 dbSNP
rs998856263 2904 dbSNP
rs553016320 2909 dbSNP
rs1032337375 2910 dbSNP
rs1482053838 2915 dbSNP
rs1388598285 2917 dbSNP
rs1000188541 2918 dbSNP
rs535932139 2920 dbSNP
rs1456199073 2925 dbSNP
rs1426904094 2926 dbSNP
rs1169184432 2931 dbSNP
rs567374955 2932 dbSNP
rs764074491 2935 dbSNP
rs1310348027 2937 dbSNP
rs1371561445 2943 dbSNP
rs1436133457 2961 dbSNP
rs1044463721 2963 dbSNP
rs948783936 2972 dbSNP
rs141883488 2973 dbSNP
rs1296998467 2992 dbSNP
rs1387938681 2993 dbSNP
rs1056995209 2995 dbSNP
rs1275200473 2998 dbSNP
rs1433322220 3001 dbSNP
rs769969648 3002 dbSNP
rs1248213354 3003 dbSNP
rs929116202 3005 dbSNP
rs919218469 3006 dbSNP
rs973718968 3008 dbSNP
rs778878067 3009 dbSNP
rs910179200 3009 dbSNP
rs985895606 3012 dbSNP
rs954415111 3013 dbSNP
rs1437499902 3014 dbSNP
rs1320064151 3018 dbSNP
rs537250371 3020 dbSNP
rs976970301 3021 dbSNP
rs956396266 3028 dbSNP
rs1277150959 3029 dbSNP
rs1206357476 3038 dbSNP
rs1031931532 3039 dbSNP
rs1322057160 3053 dbSNP
rs1207715243 3065 dbSNP
rs1245756764 3068 dbSNP
rs1465966091 3069 dbSNP
rs1341641321 3070 dbSNP
rs1236348314 3089 dbSNP
rs1387789107 3094 dbSNP
rs1472785244 3098 dbSNP
rs1000365114 3105 dbSNP
rs1416420622 3131 dbSNP
rs1235499135 3137 dbSNP
rs904551575 3145 dbSNP
rs1386814078 3159 dbSNP
rs1321362578 3163 dbSNP
rs749768331 3163 dbSNP
rs1339898937 3174 dbSNP
rs1445772900 3181 dbSNP
rs1285813229 3184 dbSNP
rs1022894279 3187 dbSNP
rs1227621777 3190 dbSNP
rs571553181 3191 dbSNP
rs1208939799 3192 dbSNP
rs551730693 3195 dbSNP
rs1403083320 3223 dbSNP
rs1440135308 3226 dbSNP
rs1012858987 3228 dbSNP
rs1239783664 3231 dbSNP
rs1352283074 3232 dbSNP
rs530076354 3237 dbSNP
rs895926861 3249 dbSNP
rs375102514 3251 dbSNP
rs1409000782 3252 dbSNP
rs1159326759 3257 dbSNP
rs201770613 3265 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuugagcgacUCGGGGu 5'
                    |||||| 
Target 5' ----------AGCCCCc 3'
 		1 - 7
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000264659.7 | 3UTR | AGCCCCCGUCCCCGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-4283 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT083347 E2F1 E2F transcription factor 1 2 4
MIRT120466 U2SURP U2 snRNP associated SURP domain containing 2 4
MIRT266892 HDGF heparin binding growth factor 2 2
MIRT445166 TFPI tissue factor pathway inhibitor 2 2
MIRT445906 SLC10A3 solute carrier family 10 member 3 2 2
MIRT455530 GJB1 gap junction protein beta 1 2 2
MIRT460172 UNK unkempt family zinc finger 2 6
MIRT461728 SLC27A1 solute carrier family 27 member 1 2 2
MIRT465219 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT468911 RPS6KA4 ribosomal protein S6 kinase A4 2 2
MIRT469691 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT471050 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT472526 NACC1 nucleus accumbens associated 1 2 2
MIRT474932 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT486980 STEAP3 STEAP3 metalloreductase 2 4
MIRT487483 BANP BTG3 associated nuclear protein 2 4
MIRT488263 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT490733 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT490896 BARHL1 BarH like homeobox 1 2 6
MIRT490909 STRN4 striatin 4 2 2
MIRT493812 FSCN1 fascin actin-bundling protein 1 2 2
MIRT509030 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 2
MIRT509049 AKAP2 A-kinase anchoring protein 2 2 2
MIRT509404 MCM7 minichromosome maintenance complex component 7 2 6
MIRT523303 HIST1H1B histone cluster 1 H1 family member b 2 2
MIRT529487 TPD52L3 tumor protein D52 like 3 2 2
MIRT529825 ARGFX arginine-fifty homeobox 2 4
MIRT542941 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT543668 PUM1 pumilio RNA binding family member 1 2 4
MIRT546994 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT560377 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT561752 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT568966 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569892 ROBO4 roundabout guidance receptor 4 2 2
MIRT570097 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT576503 Slc35e2 solute carrier family 35, member E2 2 3
MIRT623795 GK5 glycerol kinase 5 (putative) 2 2
MIRT625142 ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 2 2
MIRT631438 HSPA14 heat shock protein family A (Hsp70) member 14 2 2
MIRT633973 SLC35E2 solute carrier family 35 member E2 2 3
MIRT634811 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT640520 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT644446 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644767 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT648809 ZNF689 zinc finger protein 689 2 2
MIRT654912 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2 2
MIRT670832 SFT2D2 SFT2 domain containing 2 2 2
MIRT675826 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT684020 FOLR1 folate receptor 1 2 2
MIRT698589 TEX261 testis expressed 261 2 2
MIRT703208 GOLGA3 golgin A3 2 2
MIRT703492 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT710754 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4283 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4283 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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