pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol JUND   
Synonyms AP-1
Description JunD proto-oncogene, AP-1 transcription factor subunit
Transcript NM_005354   
Expression
Putative miRNA Targets on JUND
3'UTR of JUND
(miRNA target sites are highlighted)
>JUND|NM_005354|3'UTR
   1 GTCCGCGCGCGGGGCGCATGCGCGGCCACCCTCCCCAAGGGGCGGGCTCGCGGGGGGGTGTCGTGGGCGCCCCGGACTTG
  81 GAGAGGGTGCGGCCCTGGGGACCCCCCCTCCCCGAGTGTGCCCAGGAACTCAGAGAGGGCGCGGCCCCCGGGGATTCCCC
 161 CCCCCCGAGGGTGCCCAGGACTCGACAAGCTGGACCCCCTGCTCCCGGGGGGGCGAGCGCATGACCCCCCCGCCCTCGCG
 241 CTGCCTCTTTCCCCCGCGCGGCCGCCCCGTGTTGCACAAACCCGCGCGTCTCGGCTGCCCCTTTGTACACCGCGCCGCGG
 321 AAGGGGGCTCCGAGGGGGCGCAGCCTCAAACCCTGCCTTTCCTTTACTTTTACTTTTTTTTTTTTTTCTTTGGAAGAGAG
 401 AAGAACAGAGTGTTCGATTCTGCCCTATTTATGTTTCTACTCGGGAACAAACGTTGGTTGTGTGTGTGTGTGTTTTCTTG
 481 TGTTGGTTTTTTAAAGAAATGGGAAGAAGAAAAAAAAATTCTCCGCCCCTTTCCTCGATCTCGCTCCCCCCTTCGGTTCT
 561 TTCGACCGGTCCCCCCTCCCTTTTTTGTTCTGTTTTGTTTTGTTTTGCTACGAGTCCACATTCCTGTTTGTAATCCTTGG
 641 TTCGCCCGGTTTTCTGTTTTCAGTAAAGTCTCGTTACGCCAGCTCGGCTCTCCGCCTCCTTCTTCCCCCGCCGGGGCCTG
 721 GCGGGCTGGGCGGGGCCTGGTTCGCTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cguCGGUCG-AGAUGGGGGCGGu 5'
             |||  | ||| |||||||| 
Target 5' tccGCCTCCTTCTTCCCCCGCCg 3'
691 - 713 163.00 -28.40
2
miRNA  3' cgUCGGUCGAG-AU---GGGGGCGGu 5'
            :|| ||| | |:   |||||||| 
Target 5' ggGGCGAGCGCATGACCCCCCCGCCc 3'
210 - 235 156.00 -24.50
3
miRNA  3' cgUCG-GUC-GAGAUGGGGGCGGu 5'
            :|| ||| ||| | |||:||| 
Target 5' ggGGCGCAGCCTCAAACCCTGCCt 3'
335 - 358 148.00 -22.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31492495 39 COSMIC
COSN31932832 59 COSMIC
COSN21429497 71 COSMIC
COSN6667390 80 COSMIC
COSN27209834 177 COSMIC
COSN31524446 385 COSMIC
COSN31565622 386 COSMIC
COSN31543869 403 COSMIC
COSN29725708 459 COSMIC
COSN31517239 512 COSMIC
COSN28716460 514 COSMIC
COSN25214832 521 COSMIC
COSN26568972 548 COSMIC
COSN30539907 578 COSMIC
COSN28658538 647 COSMIC
COSN7355698 672 COSMIC
rs7249 80 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1158816684 1 dbSNP
rs1470981122 3 dbSNP
rs1361682337 7 dbSNP
rs1383543888 11 dbSNP
rs779060071 12 dbSNP
rs1180542852 15 dbSNP
rs769621355 18 dbSNP
rs1244909082 21 dbSNP
rs559347104 23 dbSNP
rs1391029934 24 dbSNP
rs780602435 26 dbSNP
rs1019398113 29 dbSNP
rs1284743855 30 dbSNP
rs1206654215 31 dbSNP
rs1382994984 33 dbSNP
rs966424025 35 dbSNP
rs1259185270 36 dbSNP
rs1007609188 37 dbSNP
rs1378171017 39 dbSNP
rs545983695 44 dbSNP
rs1317797998 46 dbSNP
rs1033149092 47 dbSNP
rs1451043512 48 dbSNP
rs1011063067 50 dbSNP
rs77680610 52 dbSNP
rs1000352178 54 dbSNP
rs1209516304 58 dbSNP
rs1030539204 59 dbSNP
rs1245356399 59 dbSNP
rs1461940547 59 dbSNP
rs1183285417 64 dbSNP
rs532178239 66 dbSNP
rs1241338919 67 dbSNP
rs1017860053 72 dbSNP
rs11550220 73 dbSNP
rs1182662262 74 dbSNP
rs1009114964 75 dbSNP
rs1357477719 77 dbSNP
rs7249 80 dbSNP
rs1041989364 82 dbSNP
rs1406618580 83 dbSNP
rs541443082 84 dbSNP
rs929394045 86 dbSNP
rs1391413189 88 dbSNP
rs527656222 88 dbSNP
rs899242418 93 dbSNP
rs1335618235 99 dbSNP
rs1038189248 101 dbSNP
rs11550221 102 dbSNP
rs1324784435 102 dbSNP
rs1261454563 103 dbSNP
rs1321151468 105 dbSNP
rs991147028 105 dbSNP
rs1196399376 107 dbSNP
rs1249918562 108 dbSNP
rs1417222151 109 dbSNP
rs41352349 109 dbSNP
rs1404459241 110 dbSNP
rs1479964604 111 dbSNP
rs939259303 114 dbSNP
rs1355858041 120 dbSNP
rs1462180478 121 dbSNP
rs927635075 122 dbSNP
rs1393771118 127 dbSNP
rs574511411 128 dbSNP
rs1422866050 133 dbSNP
rs977774432 138 dbSNP
rs1476417366 139 dbSNP
rs1346734411 143 dbSNP
rs966474931 145 dbSNP
rs1198414773 146 dbSNP
rs1309418537 148 dbSNP
rs1205575154 150 dbSNP
rs914992469 155 dbSNP
rs1224858091 157 dbSNP
rs41521444 157 dbSNP
rs1275380571 159 dbSNP
rs1490168985 159 dbSNP
rs1196929512 162 dbSNP
rs1197172647 163 dbSNP
rs3075305 164 dbSNP
rs964881257 164 dbSNP
rs1169372159 165 dbSNP
rs1317806782 166 dbSNP
rs1303255189 167 dbSNP
rs1413014719 167 dbSNP
rs141923000 167 dbSNP
rs1425966013 167 dbSNP
rs71717206 167 dbSNP
rs1292144576 168 dbSNP
rs3075300 169 dbSNP
rs1126915 172 dbSNP
rs1295075034 173 dbSNP
rs1363438360 173 dbSNP
rs1340332111 175 dbSNP
rs1272642213 176 dbSNP
rs2384994 177 dbSNP
rs1358634952 178 dbSNP
rs71309624 178 dbSNP
rs796406160 178 dbSNP
rs1435227228 179 dbSNP
rs1220234342 180 dbSNP
rs1371304160 180 dbSNP
rs1327621321 181 dbSNP
rs1463834583 182 dbSNP
rs1486096669 183 dbSNP
rs143890393 185 dbSNP
rs879939116 185 dbSNP
rs201252044 186 dbSNP
rs1399330646 187 dbSNP
rs1347494526 189 dbSNP
rs1017731753 190 dbSNP
rs761287197 196 dbSNP
rs148144313 197 dbSNP
rs560864628 197 dbSNP
rs1009579070 198 dbSNP
rs1190696228 201 dbSNP
rs954954911 202 dbSNP
rs1255163828 203 dbSNP
rs1226508474 204 dbSNP
rs1286213060 205 dbSNP
rs1317474374 206 dbSNP
rs895446030 209 dbSNP
rs377552155 211 dbSNP
rs1055868866 212 dbSNP
rs1183883613 213 dbSNP
rs1026761608 214 dbSNP
rs1241950952 214 dbSNP
rs541786656 217 dbSNP
rs1457581165 218 dbSNP
rs1011520592 224 dbSNP
rs937084510 225 dbSNP
rs183165834 229 dbSNP
rs1386977807 230 dbSNP
rs1471064350 232 dbSNP
rs899294803 232 dbSNP
rs1382353899 233 dbSNP
rs1037759309 235 dbSNP
rs1207244346 237 dbSNP
rs1281367294 241 dbSNP
rs1373883933 244 dbSNP
rs1223216958 245 dbSNP
rs894127880 250 dbSNP
rs1325484293 251 dbSNP
rs1012916688 264 dbSNP
rs1262068635 268 dbSNP
rs895000944 269 dbSNP
rs1205922829 270 dbSNP
rs909650369 279 dbSNP
rs1048163059 281 dbSNP
rs1177183127 283 dbSNP
rs1348024053 285 dbSNP
rs572706813 286 dbSNP
rs540926782 287 dbSNP
rs1405554510 288 dbSNP
rs1412990045 290 dbSNP
rs1330974177 291 dbSNP
rs976688965 293 dbSNP
rs1355247706 295 dbSNP
rs1441366954 297 dbSNP
rs927887523 299 dbSNP
rs965683726 300 dbSNP
rs1298536820 301 dbSNP
rs945018535 304 dbSNP
rs1342425189 306 dbSNP
rs1444221945 310 dbSNP
rs911859251 311 dbSNP
rs1175402038 315 dbSNP
rs986549082 316 dbSNP
rs914874888 317 dbSNP
rs1435385591 318 dbSNP
rs953387459 323 dbSNP
rs1033075586 324 dbSNP
rs1157071676 328 dbSNP
rs1439394179 332 dbSNP
rs964432518 334 dbSNP
rs1381239741 337 dbSNP
rs1426575009 347 dbSNP
rs1169919302 352 dbSNP
rs1260787662 353 dbSNP
rs978879577 355 dbSNP
rs967529528 356 dbSNP
rs1409400012 357 dbSNP
rs1020877856 359 dbSNP
rs987643837 360 dbSNP
rs1465994472 361 dbSNP
rs8106809 362 dbSNP
rs777829059 366 dbSNP
rs1270369660 367 dbSNP
rs1034061105 372 dbSNP
rs1026564498 373 dbSNP
rs1223962128 375 dbSNP
rs1382415155 376 dbSNP
rs1236066914 377 dbSNP
rs993677197 377 dbSNP
rs200632422 382 dbSNP
rs1424773446 384 dbSNP
rs758172794 385 dbSNP
rs9413 386 dbSNP
rs4393694 387 dbSNP
rs1166791465 388 dbSNP
rs1387218219 388 dbSNP
rs3075299 388 dbSNP
rs74881531 388 dbSNP
rs750430004 388 dbSNP
rs755920352 388 dbSNP
rs779907397 388 dbSNP
rs773233340 389 dbSNP
rs1382949383 392 dbSNP
rs761469291 392 dbSNP
rs1445003796 394 dbSNP
rs1247312684 397 dbSNP
rs1259926623 399 dbSNP
rs1265333427 400 dbSNP
rs576545629 401 dbSNP
rs762658051 406 dbSNP
rs1055394666 408 dbSNP
rs1464598611 409 dbSNP
rs556267060 410 dbSNP
rs1003377537 411 dbSNP
rs1245010306 415 dbSNP
rs906478688 418 dbSNP
rs750466820 420 dbSNP
rs1042314309 422 dbSNP
rs945234812 423 dbSNP
rs1158926514 431 dbSNP
rs1240942657 437 dbSNP
rs1387707689 439 dbSNP
rs1455301525 440 dbSNP
rs1338346450 442 dbSNP
rs1182585999 445 dbSNP
rs1442562540 458 dbSNP
rs1288385544 462 dbSNP
rs1309957966 464 dbSNP
rs1339219879 466 dbSNP
rs1280481657 474 dbSNP
rs780658245 474 dbSNP
rs914927139 474 dbSNP
rs943128152 474 dbSNP
rs1461951569 477 dbSNP
rs1487735977 487 dbSNP
rs1254251034 493 dbSNP
rs1420794024 496 dbSNP
rs1182502710 500 dbSNP
rs1410918436 501 dbSNP
rs1260916171 502 dbSNP
rs1178351504 503 dbSNP
rs1429469037 504 dbSNP
rs1300549200 510 dbSNP
rs910283544 510 dbSNP
rs988082780 512 dbSNP
rs1319687968 518 dbSNP
rs1393613964 519 dbSNP
rs933495438 519 dbSNP
rs1226880146 521 dbSNP
rs1285590060 524 dbSNP
rs896073653 525 dbSNP
rs536344570 526 dbSNP
rs972308089 527 dbSNP
rs1481684430 528 dbSNP
rs1233755768 529 dbSNP
rs1377350554 533 dbSNP
rs1196492783 537 dbSNP
rs41363545 540 dbSNP
rs1201308950 547 dbSNP
rs1429803818 549 dbSNP
rs41495046 550 dbSNP
rs959085254 553 dbSNP
rs1462005910 554 dbSNP
rs1035772289 555 dbSNP
rs1003337591 567 dbSNP
rs906366997 574 dbSNP
rs781502134 576 dbSNP
rs578260519 579 dbSNP
rs15212 587 dbSNP
rs1009497995 589 dbSNP
rs1385820256 590 dbSNP
rs769576919 590 dbSNP
rs1274095361 592 dbSNP
rs1290837904 595 dbSNP
rs776156203 598 dbSNP
rs1224690068 608 dbSNP
rs1339953923 608 dbSNP
rs893713880 608 dbSNP
rs1488012691 609 dbSNP
rs533896386 610 dbSNP
rs373365631 617 dbSNP
rs1166119635 620 dbSNP
rs1001597217 624 dbSNP
rs1428750536 628 dbSNP
rs557699029 633 dbSNP
rs1051525640 635 dbSNP
rs1428358693 638 dbSNP
rs1048132443 644 dbSNP
rs929761539 645 dbSNP
rs1351012437 647 dbSNP
rs896959996 649 dbSNP
rs1427387707 650 dbSNP
rs919447017 654 dbSNP
rs1436161302 660 dbSNP
rs1296933208 661 dbSNP
rs1041279409 665 dbSNP
rs1261891683 670 dbSNP
rs1389540416 671 dbSNP
rs552150750 672 dbSNP
rs1248301384 674 dbSNP
rs532369461 677 dbSNP
rs1219025874 682 dbSNP
rs747499350 685 dbSNP
rs563448649 686 dbSNP
rs1187901737 687 dbSNP
rs756796703 690 dbSNP
rs1445883247 691 dbSNP
rs985417031 693 dbSNP
rs1183695823 695 dbSNP
rs972193385 697 dbSNP
rs1214124168 698 dbSNP
rs1163102320 699 dbSNP
rs192641207 701 dbSNP
rs925976955 702 dbSNP
rs1320090543 704 dbSNP
rs751406416 705 dbSNP
rs1284856995 706 dbSNP
rs978804277 708 dbSNP
rs763749470 709 dbSNP
rs1265801380 711 dbSNP
rs1462390268 711 dbSNP
rs1203673903 713 dbSNP
rs761717454 714 dbSNP
rs981566489 716 dbSNP
rs1410837541 717 dbSNP
rs1473094925 718 dbSNP
rs1158910297 720 dbSNP
rs1020426700 722 dbSNP
rs993419014 723 dbSNP
rs529803290 726 dbSNP
rs1433540874 727 dbSNP
rs1373135313 728 dbSNP
rs758192840 728 dbSNP
rs560924258 735 dbSNP
rs1445691659 738 dbSNP
rs1001783352 739 dbSNP
rs541023467 740 dbSNP
rs1227499169 742 dbSNP
rs41355150 747 dbSNP
rs888806320 747 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgucggucGAGAUGGGGGCGGu 5'
                  :||| |||||||| 
Target 5' --------UUCUUCCCCCGCCg 3'
1 - 14
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgucggucgAGAUGGGGGCGGu 5'
                   ||| |||||||| 
Target 5' ---------UCUUCCCCCGCCg 3'
1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000252818.3 | 3UTR | UUCUUCCCCCGCCGGGGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000252818.3 | 3UTR | UCUUCCCCCGCCGGGGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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