pre-miRNA Information
pre-miRNA hsa-let-7e   
Genomic Coordinates chr19: 51692786 - 51692864
Synonyms MIRNLET7E, hsa-let-7e, let-7e, MIRLET7E
Description Homo sapiens let-7e stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7e-5p
Sequence 8| UGAGGUAGGAGGUUGUAUAGUU |29
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1189776118 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZBTB5   
Synonyms -
Description zinc finger and BTB domain containing 5
Transcript NM_014872   
Expression
Putative miRNA Targets on ZBTB5
3'UTR of ZBTB5
(miRNA target sites are highlighted)
>ZBTB5|NM_014872|3'UTR
   1 CTGTTTGTCCTTACAAGACAACGCTGAGGCCAGTTGTCAGACTGAATTTCTTTTGGTAAGCAGTTAATGCCTTTGGGTTC
  81 GAGGCTTCCAGCTGCCCAGTGGCTCTTAAACAGTTTAGCAACTAATAACCGGAGAACTAACATGTAGTATTTGTGCTGCT
 161 GCATTTCTGAGTGAAGTGCACGTCTTGGGAAAGGGATGCAATCCCTGAAACCAGGTGCTTCCTTGGGGTTGAGTAATGCA
 241 GTCAGAAAGTAGTTTGTAATTGATATTAAAAGTGGCACATTTAAAAATTTAAAAATTGAAGTGCAAAAAAAATTTTTTAG
 321 CAATTTTTGTAAAACTGTGTAGCATTTAAATTTCCTATACCTTCTGATGGGAGTATTATATCCCTGTATAGTGATGCAAA
 401 ATGCACTTATGTGTAACCAGTGGTGATTTGGTGCCTGTCTTAAAGGAAGGCCTTTGAGGACACACCTGTCTGCCACAAAT
 481 GCTTTAAAGTGTATCATGAGCTAGTCCTAGGCCTCAAAGTACTGTATTTTTTATTTTTACCTGATTTGCAGTCATAAACA
 561 CTGCACTTTGGTGCTGACACTGGGTCCAGAGTGAGCATTCTCTTGGACTATTAGATGTATATACTTTTGAATACATCACT
 641 GTTGGATAGATGTTTTAACAGTTTTTTCTGGTTTAAAAACCAAATTGTAAATGGAGTGTGTACTTGTAGAGAGTGACAAG
 721 GTATTGTTTCCCTATGTGCTGTTTGAGCAGTATTTTAACCAACTTGTATTACAGATGTTACAGTTCCATGTTAGGAAGTC
 801 AGAAAAGACTTGTGTTTGTCTTTGTTCTGCTGATGTGGAGTCATGTTTTGTGGGGTCTTCCATGGCACATTTACCTGTTG
 881 CTCCGTCCAGATGTTGAGGGCCAGTCTAGGCTGACACATCCTACCCGAGGACAAGCCTGTTCTCCATTTCTTCACTCTCC
 961 CCTCCCCATATAGCAACTCTCCCAGGTTTAGATTACCGTTTTCGACGACAGATTAACCAAAAATGCCCCACACAGGTTTT
1041 ATTACTGTTATATACTATACTTTTAACAGTACAGACCCTAAATTTTATTATTTGTTGCTCCCCCAATCTGATACCAAATG
1121 TTTAAAGTTGTTTGAAATCCAAACATGGTAGTGTTCATGGGTAAATATTTTCTAGGCTATGTAAGAGTTAGCAGCCCATA
1201 GCATAGAAGTAATCAAGTAGCATCTGAGACTGTTGGAGGCACTAGGGCCTCTCTGGGCCCTACAGCCTCACTTCCCCAGC
1281 CTCACCTTGCTGTCCTCTGACACTGCCATCAGGGCTGTTAGTGGCACCTGTATGAGGCCAAGTGTGCGTCCAGGGGAACA
1361 GCACAGGTTAATGCGTCTCCCTAGAACTCATGAAGTCAGTTTAATTCATGCATGAACATGAGTTCATTTTATGTTTTATA
1441 TAGCTTTCTTAGACATACCAAACCATCATTCATAAATCAGATAAATTATTCAGTTTTTGTGTTTAGAAAGCTAAGTATGT
1521 GTAGCTGGAAACAAAAATGAGCGTGTTTTCTCTCCTGTTAATCTAGAGTGTGCAGTTACACATGTGTGGATAATTTCATG
1601 TTCCAGGGGCGCTTGGCATCTCCCATGGACTGATTCCCAGGAAGAAAAGCCCAAAGGGAAACCCACGATTCCTTTCGAGT
1681 AGATGTGGGAAAGAGCCCATTGGAGGATATGAGGTCCTGTGAAATTCAGTTGTGTGTGTGGCTCCTTGTTAGCAGTCATG
1761 TTGACATGGTGTTAGGAGGCTCCCCATCCACCCTTTACATGATGTAGGGACCAGTGTCTTGTGAGATTAACCTTGGGACA
1841 CAGTGGGTTAGCCTGGAGAAAATGAGAGGCCCTGCCTGGACCCAGGGAGAGGAGCCAGTGACACAGGCAGAGCGGTGCAG
1921 CCCTCCTTCCCTTCCATTTGGAGGAGGTGGTGCCAGGAGCCTGCCCGCTTACCTCTGCTGAAGCATAAGTGGACTTTGCT
2001 TTTGGGGCTTATCTCTGATACATGCTGGAGCCCTGCCTCTCCACTGCTAGATGGAACCTGGAATCTCTCATCTACCTCTT
2081 AGTCTGTCAGTTTCTACGTGTGAGAAGCAAGCTTGTGGGCCAGTGTCCTTGTACATGCTGTAGCACTTAAAAAATAATTC
2161 CAGGGTTCCCTGGAAAACCAGTCCCAGGGTTCCTATGATCTGTAGTTTCTACCTGGATTATAACTGGTTTTGGGTACCTG
2241 AATTTTGATTGGTTAGCCTTAATTATAGTCTGGCGTGATCATGTAGAATCTTTTCTGGTGAACAGATCATAAAGTTCTAT
2321 CAAGGAGTTCTATCAAGGCATCCATGTCAGTGGTGCTATGCTGGTTACAACTTGAGATTTTTGAAATAAAAAATTTGTCA
2401 TATTCATGCCTCTAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uugauAUGUUGGAG----GAUGGAGu 5'
               |: ||:|||    ||||||| 
Target 5' gaaccTGGAATCTCTCATCTACCTCt 3'
2054 - 2079 155.00 -15.50
2
miRNA  3' uuGA-UAUGUUGGA-----GGAUGGAGu 5'
            || |||||  ||     |||:|||| 
Target 5' ctCTGATACATGCTGGAGCCCTGCCTCt 3'
2013 - 2040 144.00 -15.80
3
miRNA  3' uugauAUGUUGGAGGAUGGAGu 5'
               |:|  || |:|||||| 
Target 5' gagccTGC--CCGCTTACCTCt 3'
1957 - 1976 137.00 -13.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30528925 11 COSMIC
COSN27005513 22 COSMIC
COSN30510475 33 COSMIC
COSN14392752 80 COSMIC
COSN31598790 134 COSMIC
COSN22441726 137 COSMIC
COSN31529002 311 COSMIC
COSN31539760 312 COSMIC
COSN31573076 313 COSMIC
COSN31529266 314 COSMIC
COSN31544395 349 COSMIC
COSN30539824 442 COSMIC
COSN2323303 447 COSMIC
COSN20106196 723 COSMIC
COSN6390529 998 COSMIC
COSN9283261 1004 COSMIC
COSN9283260 1151 COSMIC
COSN6390528 1231 COSMIC
COSN32213049 1310 COSMIC
COSN6390527 1431 COSMIC
COSN2323301 1484 COSMIC
COSN16447542 1880 COSMIC
COSN16181211 1881 COSMIC
COSN8582728 1929 COSMIC
COSN31518429 2098 COSMIC
COSN20831667 2224 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769202485 1 dbSNP
rs747527176 2 dbSNP
rs780406941 7 dbSNP
rs758692924 14 dbSNP
rs1460462093 16 dbSNP
rs1415658901 17 dbSNP
rs746044862 19 dbSNP
rs374324471 22 dbSNP
rs757598933 23 dbSNP
rs753934910 24 dbSNP
rs764151047 25 dbSNP
rs773557887 33 dbSNP
rs756068721 34 dbSNP
rs752593639 36 dbSNP
rs767278801 37 dbSNP
rs759283583 38 dbSNP
rs201378593 39 dbSNP
rs1235613630 46 dbSNP
rs917041817 63 dbSNP
rs776111841 65 dbSNP
rs992487956 71 dbSNP
rs1473417414 75 dbSNP
rs184801425 76 dbSNP
rs961365002 80 dbSNP
rs1174366398 81 dbSNP
rs936992530 87 dbSNP
rs553513279 91 dbSNP
rs760296472 99 dbSNP
rs192991600 105 dbSNP
rs1309096720 107 dbSNP
rs1372806773 109 dbSNP
rs1403435804 111 dbSNP
rs537413067 121 dbSNP
rs1298796411 129 dbSNP
rs187897598 130 dbSNP
rs550814351 131 dbSNP
rs868430021 133 dbSNP
rs1336805585 137 dbSNP
rs1360106858 138 dbSNP
rs1477923043 142 dbSNP
rs1491178796 143 dbSNP
rs151008644 143 dbSNP
rs983337531 144 dbSNP
rs1238079033 147 dbSNP
rs1483932019 148 dbSNP
rs1353175691 149 dbSNP
rs1219937507 150 dbSNP
rs1307975224 151 dbSNP
rs955595973 170 dbSNP
rs1186438634 173 dbSNP
rs1293351643 177 dbSNP
rs866862017 181 dbSNP
rs143603489 182 dbSNP
rs141173742 187 dbSNP
rs1417311799 189 dbSNP
rs1032980575 190 dbSNP
rs1008869957 191 dbSNP
rs749633084 195 dbSNP
rs1362431105 197 dbSNP
rs1052999657 203 dbSNP
rs903077677 204 dbSNP
rs532212913 205 dbSNP
rs1344197375 214 dbSNP
rs1420542339 223 dbSNP
rs1422746788 224 dbSNP
rs935921374 228 dbSNP
rs1264633077 239 dbSNP
rs1488644804 243 dbSNP
rs1190434501 247 dbSNP
rs1259850326 250 dbSNP
rs1490477539 253 dbSNP
rs146553903 266 dbSNP
rs1214448672 267 dbSNP
rs1392636888 269 dbSNP
rs1443325304 272 dbSNP
rs1164615380 279 dbSNP
rs1369424601 280 dbSNP
rs184622618 281 dbSNP
rs1164669673 291 dbSNP
rs537266234 291 dbSNP
rs1385953199 297 dbSNP
rs1014488682 298 dbSNP
rs1320620915 306 dbSNP
rs1044247800 312 dbSNP
rs1055948878 313 dbSNP
rs898926214 313 dbSNP
rs937066611 313 dbSNP
rs948558395 314 dbSNP
rs1246659758 315 dbSNP
rs1037299377 319 dbSNP
rs1328743174 319 dbSNP
rs940385636 319 dbSNP
rs1249989663 329 dbSNP
rs529890022 336 dbSNP
rs144219714 339 dbSNP
rs1261438249 340 dbSNP
rs908786344 341 dbSNP
rs1257434706 347 dbSNP
rs983088960 355 dbSNP
rs1180077490 356 dbSNP
rs770336440 357 dbSNP
rs866659408 362 dbSNP
rs1159355499 370 dbSNP
rs544479358 378 dbSNP
rs575752504 382 dbSNP
rs759502967 386 dbSNP
rs1379762837 388 dbSNP
rs1397626619 395 dbSNP
rs1286223938 397 dbSNP
rs748349483 403 dbSNP
rs983690346 409 dbSNP
rs139606922 410 dbSNP
rs1383573402 417 dbSNP
rs967398775 418 dbSNP
rs1027902987 439 dbSNP
rs1014209212 446 dbSNP
rs974865068 446 dbSNP
rs1473089424 447 dbSNP
rs1182473420 449 dbSNP
rs746011310 452 dbSNP
rs1430988866 456 dbSNP
rs1174733120 461 dbSNP
rs964860443 468 dbSNP
rs1480639858 491 dbSNP
rs895724081 492 dbSNP
rs1019004165 507 dbSNP
rs1410162559 517 dbSNP
rs1191391139 519 dbSNP
rs1001787015 522 dbSNP
rs1365731256 523 dbSNP
rs1218779510 526 dbSNP
rs1302061347 528 dbSNP
rs755001479 530 dbSNP
rs1313956582 531 dbSNP
rs1203650229 533 dbSNP
rs898894829 534 dbSNP
rs1483601805 535 dbSNP
rs891758977 540 dbSNP
rs1037442907 541 dbSNP
rs1234299505 542 dbSNP
rs1262470042 545 dbSNP
rs1190208718 554 dbSNP
rs1425283137 556 dbSNP
rs1434351205 561 dbSNP
rs558888266 580 dbSNP
rs1166675760 591 dbSNP
rs1389446720 598 dbSNP
rs1430224375 613 dbSNP
rs1032081428 619 dbSNP
rs1309609392 627 dbSNP
rs545202864 628 dbSNP
rs940354352 631 dbSNP
rs1206986829 634 dbSNP
rs1294280781 638 dbSNP
rs573299760 645 dbSNP
rs145784269 647 dbSNP
rs904422036 649 dbSNP
rs1204611202 651 dbSNP
rs1051872495 652 dbSNP
rs1231144757 657 dbSNP
rs934228334 658 dbSNP
rs922859647 660 dbSNP
rs1220406686 661 dbSNP
rs1044361911 666 dbSNP
rs1246887082 668 dbSNP
rs1469450685 668 dbSNP
rs149824327 672 dbSNP
rs567479519 675 dbSNP
rs191290855 684 dbSNP
rs926011380 693 dbSNP
rs1411374982 694 dbSNP
rs1404496505 707 dbSNP
rs1056844909 709 dbSNP
rs1165784152 714 dbSNP
rs1351799918 715 dbSNP
rs978872876 719 dbSNP
rs967366577 725 dbSNP
rs1365940286 726 dbSNP
rs1437922958 726 dbSNP
rs34811555 729 dbSNP
rs386414933 729 dbSNP
rs10639606 730 dbSNP
rs2308190 730 dbSNP
rs939774388 734 dbSNP
rs913192392 738 dbSNP
rs1336478222 741 dbSNP
rs1206358294 742 dbSNP
rs1266940784 750 dbSNP
rs1464909516 752 dbSNP
rs1472364271 763 dbSNP
rs1182206993 768 dbSNP
rs537346178 771 dbSNP
rs1455837656 772 dbSNP
rs1158634474 777 dbSNP
rs1389502129 781 dbSNP
rs1168313126 789 dbSNP
rs1332816474 790 dbSNP
rs1248888219 807 dbSNP
rs1461378173 819 dbSNP
rs770683186 820 dbSNP
rs1340373556 836 dbSNP
rs1048534995 839 dbSNP
rs1286320343 843 dbSNP
rs993245420 850 dbSNP
rs1226202576 856 dbSNP
rs931005605 858 dbSNP
rs1329279831 862 dbSNP
rs1206348950 873 dbSNP
rs1276473003 874 dbSNP
rs920833458 882 dbSNP
rs1195324745 883 dbSNP
rs1422118147 884 dbSNP
rs187982894 885 dbSNP
rs1259374368 886 dbSNP
rs1184405660 888 dbSNP
rs1462847179 890 dbSNP
rs552135460 900 dbSNP
rs531978217 901 dbSNP
rs1034697945 910 dbSNP
rs779787171 911 dbSNP
rs1170882353 919 dbSNP
rs1402203263 920 dbSNP
rs1415553198 921 dbSNP
rs1315283986 926 dbSNP
rs912052862 927 dbSNP
rs987689464 943 dbSNP
rs1287371936 945 dbSNP
rs116009302 947 dbSNP
rs1015964663 954 dbSNP
rs1253595374 955 dbSNP
rs1031779321 957 dbSNP
rs183226363 962 dbSNP
rs1319384305 968 dbSNP
rs886199895 968 dbSNP
rs1000183440 970 dbSNP
rs1204149606 972 dbSNP
rs1252885436 973 dbSNP
rs1439775390 977 dbSNP
rs1196946203 992 dbSNP
rs771083260 995 dbSNP
rs758362762 997 dbSNP
rs1478368130 998 dbSNP
rs1452864232 1002 dbSNP
rs529925091 1003 dbSNP
rs78934180 1006 dbSNP
rs139886359 1007 dbSNP
rs1397017223 1015 dbSNP
rs1308999511 1016 dbSNP
rs1396848431 1022 dbSNP
rs150682677 1025 dbSNP
rs1321123097 1030 dbSNP
rs1330037973 1032 dbSNP
rs895615988 1033 dbSNP
rs1234348330 1036 dbSNP
rs1305605032 1037 dbSNP
rs1057361537 1051 dbSNP
rs1384640680 1053 dbSNP
rs1227480000 1055 dbSNP
rs566190371 1057 dbSNP
rs564996625 1059 dbSNP
rs1164316839 1060 dbSNP
rs1446604760 1062 dbSNP
rs1004090643 1065 dbSNP
rs1236590723 1068 dbSNP
rs942836000 1069 dbSNP
rs926146682 1072 dbSNP
rs1266892293 1076 dbSNP
rs1452294051 1094 dbSNP
rs886842415 1094 dbSNP
rs1195557689 1096 dbSNP
rs1438743115 1104 dbSNP
rs571702998 1105 dbSNP
rs1253168683 1106 dbSNP
rs145679706 1122 dbSNP
rs1359394598 1125 dbSNP
rs1456679077 1125 dbSNP
rs1290337107 1126 dbSNP
rs1389544023 1134 dbSNP
rs776789819 1135 dbSNP
rs1327328227 1146 dbSNP
rs1362313758 1148 dbSNP
rs1434301428 1149 dbSNP
rs1361058628 1158 dbSNP
rs1306611637 1160 dbSNP
rs7039333 1164 dbSNP
rs920929843 1180 dbSNP
rs140676796 1189 dbSNP
rs551929614 1189 dbSNP
rs1265134140 1196 dbSNP
rs1215702778 1198 dbSNP
rs913319711 1200 dbSNP
rs1039224978 1204 dbSNP
rs1189812437 1229 dbSNP
rs1264440346 1231 dbSNP
rs1330670787 1249 dbSNP
rs1422488709 1255 dbSNP
rs943614377 1255 dbSNP
rs1384955698 1263 dbSNP
rs1424186275 1266 dbSNP
rs1187266012 1271 dbSNP
rs1364895483 1277 dbSNP
rs1303763707 1291 dbSNP
rs117163461 1292 dbSNP
rs1385835122 1293 dbSNP
rs1378613730 1298 dbSNP
rs1289410162 1305 dbSNP
rs551882510 1317 dbSNP
rs1394128807 1330 dbSNP
rs1158191072 1332 dbSNP
rs988027046 1337 dbSNP
rs1470659784 1340 dbSNP
rs542702668 1341 dbSNP
rs1286628912 1342 dbSNP
rs1328632766 1347 dbSNP
rs924661003 1348 dbSNP
rs1263078006 1350 dbSNP
rs980027916 1358 dbSNP
rs963267200 1360 dbSNP
rs978859920 1364 dbSNP
rs1476364579 1366 dbSNP
rs968669023 1367 dbSNP
rs1256193047 1370 dbSNP
rs1022979880 1375 dbSNP
rs1472004589 1377 dbSNP
rs1225441441 1378 dbSNP
rs532705613 1381 dbSNP
rs1281572963 1389 dbSNP
rs1012956475 1393 dbSNP
rs1247618995 1396 dbSNP
rs1302132271 1399 dbSNP
rs960228924 1402 dbSNP
rs1204143152 1403 dbSNP
rs950475375 1407 dbSNP
rs1306459309 1420 dbSNP
rs1035638347 1426 dbSNP
rs565528767 1433 dbSNP
rs1030519889 1439 dbSNP
rs7038960 1440 dbSNP
rs1310461513 1441 dbSNP
rs1221465476 1444 dbSNP
rs1281622370 1448 dbSNP
rs1344717702 1451 dbSNP
rs1283839451 1461 dbSNP
rs1406750973 1469 dbSNP
rs7022431 1470 dbSNP
rs1203423118 1474 dbSNP
rs1018533076 1477 dbSNP
rs1480101676 1480 dbSNP
rs1177357088 1484 dbSNP
rs537382906 1484 dbSNP
rs578208909 1485 dbSNP
rs1007106546 1486 dbSNP
rs1048091629 1487 dbSNP
rs1175310313 1487 dbSNP
rs369465069 1488 dbSNP
rs1436419875 1496 dbSNP
rs995224144 1497 dbSNP
rs1166480489 1519 dbSNP
rs1369645653 1523 dbSNP
rs1443226287 1528 dbSNP
rs899623822 1533 dbSNP
rs1387433008 1542 dbSNP
rs1171117899 1543 dbSNP
rs1304867465 1550 dbSNP
rs1226731163 1554 dbSNP
rs1274376137 1568 dbSNP
rs1039339515 1569 dbSNP
rs1308389001 1573 dbSNP
rs1204804067 1576 dbSNP
rs763863155 1579 dbSNP
rs1054696223 1584 dbSNP
rs1487248376 1584 dbSNP
rs768930898 1584 dbSNP
rs1192452006 1600 dbSNP
rs1253620973 1602 dbSNP
rs904783473 1606 dbSNP
rs890688835 1610 dbSNP
rs1052034649 1611 dbSNP
rs946214590 1617 dbSNP
rs558142578 1625 dbSNP
rs1457517689 1627 dbSNP
rs1326654287 1630 dbSNP
rs190685437 1636 dbSNP
rs1297450096 1640 dbSNP
rs1363129061 1647 dbSNP
rs978808845 1650 dbSNP
rs1274754991 1651 dbSNP
rs1239809082 1656 dbSNP
rs775099701 1658 dbSNP
rs530393493 1659 dbSNP
rs927247505 1663 dbSNP
rs566306619 1666 dbSNP
rs991472189 1667 dbSNP
rs546760377 1676 dbSNP
rs562931430 1677 dbSNP
rs983231841 1678 dbSNP
rs1263576294 1682 dbSNP
rs770279366 1683 dbSNP
rs1165853179 1684 dbSNP
rs950638893 1685 dbSNP
rs567500665 1692 dbSNP
rs1455672048 1695 dbSNP
rs1320517877 1698 dbSNP
rs1346295147 1708 dbSNP
rs1433412298 1709 dbSNP
rs1282795319 1712 dbSNP
rs188825631 1719 dbSNP
rs1293490882 1730 dbSNP
rs1336362548 1731 dbSNP
rs1206262006 1733 dbSNP
rs1283542272 1749 dbSNP
rs1026765108 1766 dbSNP
rs1359810019 1771 dbSNP
rs574183027 1774 dbSNP
rs1235532070 1776 dbSNP
rs1269611644 1780 dbSNP
rs995337133 1788 dbSNP
rs1188959845 1794 dbSNP
rs1420250669 1796 dbSNP
rs1471678859 1798 dbSNP
rs1158064626 1799 dbSNP
rs1431578030 1800 dbSNP
rs976275097 1806 dbSNP
rs899573194 1815 dbSNP
rs879791601 1816 dbSNP
rs1008279389 1822 dbSNP
rs1332717876 1827 dbSNP
rs1375256449 1829 dbSNP
rs1415752197 1832 dbSNP
rs964493564 1833 dbSNP
rs528489284 1836 dbSNP
rs890814940 1837 dbSNP
rs183428008 1840 dbSNP
rs1226108660 1841 dbSNP
rs1278445960 1843 dbSNP
rs1407247826 1845 dbSNP
rs1225413498 1846 dbSNP
rs1052409085 1850 dbSNP
rs1485244120 1851 dbSNP
rs1211302879 1852 dbSNP
rs1464467391 1853 dbSNP
rs191525510 1855 dbSNP
rs1021907093 1863 dbSNP
rs903470984 1865 dbSNP
rs13300415 1868 dbSNP
rs1043245595 1872 dbSNP
rs1471179395 1876 dbSNP
rs1171385091 1877 dbSNP
rs1010390281 1879 dbSNP
rs1435795731 1880 dbSNP
rs947562491 1882 dbSNP
rs915987341 1883 dbSNP
rs991602948 1884 dbSNP
rs1475450726 1887 dbSNP
rs1243399666 1889 dbSNP
rs41278301 1892 dbSNP
rs1389330858 1896 dbSNP
rs1327706597 1906 dbSNP
rs1057304600 1910 dbSNP
rs928659051 1913 dbSNP
rs768924969 1914 dbSNP
rs1205348266 1915 dbSNP
rs41278299 1916 dbSNP
rs942061864 1920 dbSNP
rs1282220036 1921 dbSNP
rs1339748439 1924 dbSNP
rs1272197824 1925 dbSNP
rs909122333 1936 dbSNP
rs1026880091 1942 dbSNP
rs71504531 1944 dbSNP
rs1251480600 1947 dbSNP
rs1439688008 1948 dbSNP
rs983364207 1962 dbSNP
rs780128661 1966 dbSNP
rs186280639 1967 dbSNP
rs559318139 1970 dbSNP
rs1452127189 1972 dbSNP
rs1383814626 1976 dbSNP
rs1167005340 1979 dbSNP
rs1396739827 1980 dbSNP
rs1339027886 1981 dbSNP
rs1440459021 1984 dbSNP
rs1354374737 1986 dbSNP
rs1171711045 1988 dbSNP
rs2840246 1989 dbSNP
rs1420981198 1990 dbSNP
rs964787958 1992 dbSNP
rs1305486812 1995 dbSNP
rs1324511369 1998 dbSNP
rs1226397261 1999 dbSNP
rs1443572818 2000 dbSNP
rs147346447 2015 dbSNP
rs563408281 2019 dbSNP
rs182245071 2025 dbSNP
rs578077580 2026 dbSNP
rs1205082486 2030 dbSNP
rs1439513323 2034 dbSNP
rs557406771 2039 dbSNP
rs999638177 2039 dbSNP
rs567349895 2046 dbSNP
rs1373358030 2052 dbSNP
rs1332738802 2063 dbSNP
rs1245339174 2066 dbSNP
rs1162287671 2067 dbSNP
rs1393137743 2068 dbSNP
rs1021883906 2070 dbSNP
rs1010867516 2071 dbSNP
rs1382683625 2076 dbSNP
rs1381508383 2078 dbSNP
rs1222335534 2081 dbSNP
rs1327916684 2082 dbSNP
rs956323942 2082 dbSNP
rs1292856177 2085 dbSNP
rs1335593999 2086 dbSNP
rs1373018206 2089 dbSNP
rs1802995 2094 dbSNP
rs1266841991 2097 dbSNP
rs1036239696 2098 dbSNP
rs903419063 2104 dbSNP
rs1441011234 2115 dbSNP
rs1003063646 2120 dbSNP
rs142716776 2135 dbSNP
rs1444935438 2160 dbSNP
rs1475283641 2164 dbSNP
rs75994273 2165 dbSNP
rs764341061 2169 dbSNP
rs1361491854 2176 dbSNP
rs1452978975 2177 dbSNP
rs1011725171 2183 dbSNP
rs1006171657 2192 dbSNP
rs887816480 2193 dbSNP
rs1047725034 2194 dbSNP
rs1356320007 2196 dbSNP
rs929178444 2199 dbSNP
rs1385381150 2209 dbSNP
rs1304963702 2220 dbSNP
rs923223585 2221 dbSNP
rs757031986 2222 dbSNP
rs1240428865 2229 dbSNP
rs138716946 2236 dbSNP
rs1346229121 2240 dbSNP
rs1210603710 2247 dbSNP
rs938771001 2257 dbSNP
rs1256452160 2265 dbSNP
rs910289001 2266 dbSNP
rs72739646 2273 dbSNP
rs1417956874 2274 dbSNP
rs552987048 2275 dbSNP
rs1177582933 2282 dbSNP
rs536217617 2288 dbSNP
rs143979782 2290 dbSNP
rs956467830 2303 dbSNP
rs1035971934 2308 dbSNP
rs550648380 2317 dbSNP
rs1003441794 2319 dbSNP
rs970236335 2323 dbSNP
rs973977893 2325 dbSNP
rs963806270 2330 dbSNP
rs1309863912 2336 dbSNP
rs1490526957 2339 dbSNP
rs1234121865 2340 dbSNP
rs1006222055 2344 dbSNP
rs1294098636 2346 dbSNP
rs887868549 2351 dbSNP
rs1249226318 2352 dbSNP
rs41278297 2357 dbSNP
rs75668063 2360 dbSNP
rs1240020644 2364 dbSNP
rs1452508797 2374 dbSNP
rs1192867084 2388 dbSNP
rs901739774 2392 dbSNP
rs955149058 2393 dbSNP
rs1168666409 2394 dbSNP
rs1354146895 2394 dbSNP
rs1462623363 2398 dbSNP
rs1299977299 2400 dbSNP
rs1368809965 2404 dbSNP
rs1440855455 2404 dbSNP
rs1304752192 2410 dbSNP
rs1373695070 2412 dbSNP
rs1213152095 2416 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uugauaugUUGGAG----GAUGGAGu 5'
                  ||:|||    ||||||| 
Target 5' --------AAUCUCUCAUCUACCUCu 3'
1 - 18
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9925.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000307750.4 | 3UTR | AACCUGGAAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000307750.4 | 3UTR | AAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000307750.4 | 3UTR | AUGGAACCUGGAAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000307750.4 | 3UTR | AAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000307750.4 | 3UTR | AACCUGGAAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000307750.4 | 3UTR | AAUCUCUCAUCUACCUCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH -0.432 0.02 -0.353 0.04 25 Click to see details
STAD -0.365 0.02 -0.272 0.07 32 Click to see details
LIHC -0.228 0.06 -0.051 0.36 49 Click to see details
KIRP -0.262 0.07 -0.341 0.03 32 Click to see details
PCPG 0.956 0.09 1.000 0.5 3 Click to see details
BLCA -0.307 0.11 -0.300 0.11 18 Click to see details
HNSC -0.189 0.12 -0.289 0.03 42 Click to see details
PAAD -0.739 0.13 -0.800 0.1 4 Click to see details
THCA 0.118 0.19 0.171 0.1 59 Click to see details
COAD 0.347 0.2 0.429 0.14 8 Click to see details
BRCA -0.07 0.26 -0.042 0.35 84 Click to see details
ESCA -0.118 0.36 -0.045 0.45 11 Click to see details
PRAD -0.05 0.37 -0.050 0.37 50 Click to see details
LUAD 0.099 0.38 0.056 0.43 12 Click to see details
KIRC 0.031 0.4 0.043 0.36 68 Click to see details
UCEC -0.052 0.42 -0.049 0.42 19 Click to see details
LUSC 0.015 0.46 -0.067 0.34 38 Click to see details
CHOL 0.032 0.47 0.033 0.47 9 Click to see details
CESC 0.075 0.48 -0.500 0.33 3 Click to see details
CESC 0.075 0.48 -0.500 0.33 3 Click to see details
CESC 0.075 0.48 -0.500 0.33 3 Click to see details
581 hsa-let-7e-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002081 HMGA2 high mobility group AT-hook 2 5 5
MIRT003932 EIF3J eukaryotic translation initiation factor 3 subunit J 2 1
MIRT004469 SMC1A structural maintenance of chromosomes 1A 4 7
MIRT005718 WNT1 Wnt family member 1 4 1
MIRT006122 CCND1 cyclin D1 5 4
MIRT006404 MPL MPL proto-oncogene, thrombopoietin receptor 1 1
MIRT032098 RABGAP1L RAB GTPase activating protein 1 like 1 1
MIRT032099 DAD1 defender against cell death 1 1 1
MIRT032100 MYCN MYCN proto-oncogene, bHLH transcription factor 4 2
MIRT051413 WDR67 TBC1 domain family member 31 1 1
MIRT051414 FAM219B family with sequence similarity 219 member B 1 1
MIRT051415 C11orf91 chromosome 11 open reading frame 91 1 1
MIRT051416 CENPP centromere protein P 1 1
MIRT051417 TMEM107 transmembrane protein 107 1 1
MIRT051418 SREBF1 sterol regulatory element binding transcription factor 1 1 1
MIRT051419 DAAM1 dishevelled associated activator of morphogenesis 1 1 1
MIRT051420 DGCR8 DGCR8, microprocessor complex subunit 1 1
MIRT051421 RAP1A RAP1A, member of RAS oncogene family 1 1
MIRT051422 RPA1 replication protein A1 1 1
MIRT051423 SKIV2L Ski2 like RNA helicase 1 1
MIRT051424 AGO1 argonaute 1, RISC catalytic component 4 2
MIRT051425 RPS27 ribosomal protein S27 1 1
MIRT051426 ARNT2 aryl hydrocarbon receptor nuclear translocator 2 1 1
MIRT051427 GPM6B glycoprotein M6B 1 1
MIRT051428 TTLL12 tubulin tyrosine ligase like 12 1 1
MIRT051429 HIST2H2BF histone cluster 2 H2B family member f 1 1
MIRT051430 CELF2 CUGBP Elav-like family member 2 1 1
MIRT051431 AGO2 argonaute 2, RISC catalytic component 1 1
MIRT051432 VPS13D vacuolar protein sorting 13 homolog D 1 1
MIRT051433 RPL10 ribosomal protein L10 1 1
MIRT051434 SPCS2 signal peptidase complex subunit 2 1 1
MIRT051435 DCAF8 DDB1 and CUL4 associated factor 8 1 1
MIRT051436 CTC1 CST telomere replication complex component 1 1 1
MIRT051437 NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 1 1
MIRT051438 PHF3 PHD finger protein 3 1 1
MIRT051439 TUBA1B tubulin alpha 1b 1 1
MIRT051440 SHANK1 SH3 and multiple ankyrin repeat domains 1 1 1
MIRT051441 SKA2 spindle and kinetochore associated complex subunit 2 1 1
MIRT051442 SPTBN1 spectrin beta, non-erythrocytic 1 1 1
MIRT051443 ND2 MTND2 1 1
MIRT051444 MED13L mediator complex subunit 13 like 1 1
MIRT051445 RCOR3 REST corepressor 3 1 1
MIRT051446 MACF1 microtubule-actin crosslinking factor 1 1 1
MIRT051447 RDX radixin 2 5
MIRT051448 PCBP2 poly(rC) binding protein 2 1 1
MIRT051449 UBAP2L ubiquitin associated protein 2 like 1 1
MIRT051450 CDCA3 cell division cycle associated 3 1 1
MIRT051451 CABLES1 Cdk5 and Abl enzyme substrate 1 1 1
MIRT051452 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1 1
MIRT051453 C12orf49 chromosome 12 open reading frame 49 1 1
MIRT051454 TIMP3 TIMP metallopeptidase inhibitor 3 1 1
MIRT051455 WBSCR16 RCC1 like 1 1
MIRT051456 SLC2A11 solute carrier family 2 member 11 1 1
MIRT051457 NF1 neurofibromin 1 1 1
MIRT051458 LRRC8A leucine rich repeat containing 8 VRAC subunit A 1 1
MIRT051459 RUNX1T1 RUNX1 translocation partner 1 1 1
MIRT051460 DTNB dystrobrevin beta 1 1
MIRT051461 SCMH1 Scm polycomb group protein homolog 1 1 1
MIRT051462 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 1 1
MIRT051463 RHBDD2 rhomboid domain containing 2 1 1
MIRT051464 ND5 NADH dehydrogenase, subunit 5 (complex I) 1 1
MIRT051465 NDST1 N-deacetylase and N-sulfotransferase 1 1 1
MIRT051466 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 5
MIRT051467 EIF4A1 eukaryotic translation initiation factor 4A1 1 1
MIRT051468 BAHCC1 BAH domain and coiled-coil containing 1 1 1
MIRT051469 CARM1 coactivator associated arginine methyltransferase 1 1 1
MIRT051470 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 1 1
MIRT051471 ND3 NADH dehydrogenase, subunit 3 (complex I) 1 1
MIRT051472 PIGS phosphatidylinositol glycan anchor biosynthesis class S 1 1
MIRT051473 ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 1 1
MIRT051474 RPN2 ribophorin II 1 1
MIRT051475 RPL12 ribosomal protein L12 1 1
MIRT051476 NME4 NME/NM23 nucleoside diphosphate kinase 4 1 1
MIRT051477 IVD isovaleryl-CoA dehydrogenase 1 1
MIRT051478 JAZF1 JAZF zinc finger 1 1 1
MIRT051479 ND4 NADH dehydrogenase, subunit 4 (complex I) 1 1
MIRT051480 VARS valyl-tRNA synthetase 1 1
MIRT051481 RNF26 ring finger protein 26 1 1
MIRT051482 LHFPL2 LHFPL tetraspan subfamily member 2 1 1
MIRT051483 ARCN1 archain 1 1 1
MIRT051484 COX1 cytochrome c oxidase subunit I 1 1
MIRT051485 SLC12A4 solute carrier family 12 member 4 1 1
MIRT051486 AEBP2 AE binding protein 2 1 1
MIRT051487 PET112 glutamyl-tRNA amidotransferase subunit B 1 1
MIRT051488 UROC1 urocanate hydratase 1 1 1
MIRT051489 IGF1R insulin like growth factor 1 receptor 5 10
MIRT051490 BSDC1 BSD domain containing 1 1 1
MIRT051491 PTK2 protein tyrosine kinase 2 1 1
MIRT051492 CDC5L cell division cycle 5 like 1 1
MIRT051493 EN2 engrailed homeobox 2 1 1
MIRT051494 SSB Sjogren syndrome antigen B 1 1
MIRT051495 SLCO3A1 solute carrier organic anion transporter family member 3A1 1 1
MIRT051496 RRAGC Ras related GTP binding C 1 1
MIRT051497 ZNF236 zinc finger protein 236 1 1
MIRT051498 SEMA4B semaphorin 4B 1 1
MIRT051499 SERBP1 SERPINE1 mRNA binding protein 1 1 1
MIRT051500 XIAP X-linked inhibitor of apoptosis 1 1
MIRT051501 GTF2I general transcription factor IIi 1 1
MIRT051502 JMJD1C jumonji domain containing 1C 1 1
MIRT051503 OTUD5 OTU deubiquitinase 5 1 1
MIRT051504 NOLC1 nucleolar and coiled-body phosphoprotein 1 1 1
MIRT051505 PPIG peptidylprolyl isomerase G 1 1
MIRT051506 PSMD2 proteasome 26S subunit, non-ATPase 2 1 1
MIRT051507 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1 1
MIRT051508 VAMP2 vesicle associated membrane protein 2 1 1
MIRT051509 LSR lipolysis stimulated lipoprotein receptor 1 1
MIRT051510 KIAA0355 KIAA0355 1 1
MIRT051511 RPSA ribosomal protein SA 1 1
MIRT051512 DCAF6 DDB1 and CUL4 associated factor 6 1 1
MIRT051513 UHRF1BP1 UHRF1 binding protein 1 1 1
MIRT051514 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 1 1
MIRT051515 PIGP phosphatidylinositol glycan anchor biosynthesis class P 1 1
MIRT051516 LMLN leishmanolysin like peptidase 1 1
MIRT051517 PPP2R1A protein phosphatase 2 scaffold subunit Aalpha 1 1
MIRT051518 HIPK1 homeodomain interacting protein kinase 1 1 1
MIRT051519 SERF2 small EDRK-rich factor 2 1 1
MIRT051520 RBM4 RNA binding motif protein 4 1 1
MIRT051521 RBM14 RNA binding motif protein 14 1 1
MIRT051522 HMGB1 high mobility group box 1 1 1
MIRT051523 GMPS guanine monophosphate synthase 1 1
MIRT051524 DIAPH1 diaphanous related formin 1 1 1
MIRT051525 STAM signal transducing adaptor molecule 1 1
MIRT051526 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 1 1
MIRT051527 APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 1 1
MIRT051528 MARCH5 membrane associated ring-CH-type finger 5 1 1
MIRT051529 SQLE squalene epoxidase 1 1
MIRT051530 TIMM50 translocase of inner mitochondrial membrane 50 1 1
MIRT051531 NDUFA3 NADH:ubiquinone oxidoreductase subunit A3 1 1
MIRT051532 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 1 1
MIRT051533 NRSN2 neurensin 2 1 1
MIRT051534 SALL1 spalt like transcription factor 1 1 1
MIRT051535 COX3 cytochrome c oxidase III 1 1
MIRT051536 RABL6 RAB, member RAS oncogene family like 6 1 1
MIRT051537 SUPT4H1 SPT4 homolog, DSIF elongation factor subunit 1 1
MIRT051538 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT051539 MTMR14 myotubularin related protein 14 1 1
MIRT051540 LUZP1 leucine zipper protein 1 1 1
MIRT051541 PFAS phosphoribosylformylglycinamidine synthase 1 1
MIRT051542 SUZ12 SUZ12 polycomb repressive complex 2 subunit 1 1
MIRT051543 PAPD4 poly(A) RNA polymerase D4, non-canonical 1 1
MIRT051544 QSOX1 quiescin sulfhydryl oxidase 1 1 1
MIRT051545 SPATA13 spermatogenesis associated 13 1 1
MIRT051546 DHX57 DExH-box helicase 57 1 1
MIRT051547 KATNB1 katanin regulatory subunit B1 1 1
MIRT051548 COL6A1 collagen type VI alpha 1 chain 1 1
MIRT051549 DHX15 DEAH-box helicase 15 1 1
MIRT051550 MTCH2 mitochondrial carrier 2 1 1
MIRT051551 KIAA0100 KIAA0100 1 1
MIRT051552 SUGP2 SURP and G-patch domain containing 2 1 1
MIRT051553 NCLN nicalin 1 1
MIRT051554 ATXN2L ataxin 2 like 1 1
MIRT051555 CHD9 chromodomain helicase DNA binding protein 9 1 1
MIRT051556 PES1 pescadillo ribosomal biogenesis factor 1 1 1
MIRT051557 NUP155 nucleoporin 155 2 7
MIRT051558 GNG5 G protein subunit gamma 5 2 3
MIRT051559 ARHGAP19 Rho GTPase activating protein 19 1 1
MIRT051560 MTFR1 mitochondrial fission regulator 1 1 1
MIRT051561 IRS2 insulin receptor substrate 2 2 1
MIRT051562 IRS4 insulin receptor substrate 4 1 1
MIRT051563 PPP1R10 protein phosphatase 1 regulatory subunit 10 1 1
MIRT051564 ZNF284 zinc finger protein 284 1 1
MIRT051565 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 1 1
MIRT051566 SCD stearoyl-CoA desaturase 1 1
MIRT051567 FDPS farnesyl diphosphate synthase 1 1
MIRT051568 KRBOX4 KRAB box domain containing 4 1 1
MIRT051569 BRI3 brain protein I3 1 1
MIRT051570 CHD7 chromodomain helicase DNA binding protein 7 1 1
MIRT051571 PYCR1 pyrroline-5-carboxylate reductase 1 1 1
MIRT051572 SMAP2 small ArfGAP2 1 1
MIRT051573 WDFY3 WD repeat and FYVE domain containing 3 1 1
MIRT051574 CRK CRK proto-oncogene, adaptor protein 1 1
MIRT051575 SRSF2 serine and arginine rich splicing factor 2 1 1
MIRT051576 PGD phosphogluconate dehydrogenase 1 1
MIRT051577 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT051578 ZNF652 zinc finger protein 652 1 1
MIRT051579 PSMA6 proteasome subunit alpha 6 1 1
MIRT051580 SLC38A2 solute carrier family 38 member 2 1 1
MIRT051581 LRRC41 leucine rich repeat containing 41 1 1
MIRT051582 RANBP2 RAN binding protein 2 1 1
MIRT051583 SVIL supervillin 1 1
MIRT051584 CCNG1 cyclin G1 1 1
MIRT051585 ZNF256 zinc finger protein 256 1 1
MIRT051586 COPG1 coatomer protein complex subunit gamma 1 1 1
MIRT051587 PDCD11 programmed cell death 11 1 1
MIRT051588 CNBP CCHC-type zinc finger nucleic acid binding protein 1 1
MIRT051589 USP37 ubiquitin specific peptidase 37 1 1
MIRT051590 UBE2V2 ubiquitin conjugating enzyme E2 V2 1 1
MIRT051591 UBE2H ubiquitin conjugating enzyme E2 H 1 1
MIRT051592 LMNA lamin A/C 1 1
MIRT051593 STAT3 signal transducer and activator of transcription 3 1 1
MIRT051594 TRPV1 transient receptor potential cation channel subfamily V member 1 1 1
MIRT051595 MATR3 matrin 3 1 1
MIRT051596 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1 1
MIRT051597 HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1 1
MIRT051598 WDR48 WD repeat domain 48 1 1
MIRT051599 RBM8A RNA binding motif protein 8A 1 1
MIRT051600 SCYL1 SCY1 like pseudokinase 1 1 1
MIRT051601 C19orf48 chromosome 19 open reading frame 48 1 1
MIRT051602 FOXD4L6 forkhead box D4 like 6 1 1
MIRT051603 PIGN phosphatidylinositol glycan anchor biosynthesis class N 1 1
MIRT051604 SPCS3 signal peptidase complex subunit 3 1 1
MIRT051605 TNFAIP1 TNF alpha induced protein 1 1 1
MIRT051606 MS4A10 membrane spanning 4-domains A10 1 1
MIRT051607 MSMO1 methylsterol monooxygenase 1 1 1
MIRT051608 ARID1A AT-rich interaction domain 1A 1 1
MIRT051609 NCKIPSD NCK interacting protein with SH3 domain 2 5
MIRT051610 NCBP1 nuclear cap binding protein subunit 1 1 1
MIRT051611 COX16 COX16, cytochrome c oxidase assembly homolog 1 1
MIRT051612 NUDT8 nudix hydrolase 8 1 1
MIRT051613 PHKA1 phosphorylase kinase regulatory subunit alpha 1 1 1
MIRT051614 TXNRD1 thioredoxin reductase 1 1 1
MIRT051615 ELMSAN1 ELM2 and Myb/SANT domain containing 1 1 1
MIRT051616 CTSA cathepsin A 1 1
MIRT051617 PRRC2A proline rich coiled-coil 2A 1 1
MIRT051618 SPAG9 sperm associated antigen 9 1 1
MIRT051619 AGMAT agmatinase 1 1
MIRT051620 NCKAP5L NCK associated protein 5 like 1 1
MIRT051621 ZFP62 ZFP62 zinc finger protein 1 1
MIRT051622 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1 1
MIRT051623 POLR3D RNA polymerase III subunit D 2 3
MIRT051624 PRPF8 pre-mRNA processing factor 8 1 1
MIRT051625 ATP6 ATP synthase F0 subunit 6 1 1
MIRT051626 ZFAND5 zinc finger AN1-type containing 5 1 1
MIRT051627 BAZ1B bromodomain adjacent to zinc finger domain 1B 1 1
MIRT051628 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT051629 BMP2K BMP2 inducible kinase 1 1
MIRT051630 SPN sialophorin 1 1
MIRT051631 PA2G4 proliferation-associated 2G4 1 1
MIRT051632 RPRD2 regulation of nuclear pre-mRNA domain containing 2 1 1
MIRT051633 TUBB4B tubulin beta 4B class IVb 1 1
MIRT051634 TRRAP transformation/transcription domain associated protein 1 1
MIRT051635 SLCO4A1 solute carrier organic anion transporter family member 4A1 1 1
MIRT051636 CCRN4L nocturnin 1 1
MIRT051637 USE1 unconventional SNARE in the ER 1 1 1
MIRT051638 STARD7 StAR related lipid transfer domain containing 7 1 1
MIRT051639 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 3
MIRT051640 CLTC clathrin heavy chain 1 1
MIRT051641 TERF1 telomeric repeat binding factor 1 1 1
MIRT051642 PAX3 paired box 3 1 1
MIRT051643 CCDC97 coiled-coil domain containing 97 1 1
MIRT051644 HLA-C major histocompatibility complex, class I, C 1 1
MIRT051645 GTPBP8 GTP binding protein 8 (putative) 1 1
MIRT051646 VGLL4 vestigial like family member 4 1 1
MIRT051647 ANKRD40 ankyrin repeat domain 40 1 1
MIRT051648 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 1 1
MIRT051649 ND1 NADH dehydrogenase, subunit 1 (complex I) 1 1
MIRT051650 DSP desmoplakin 1 1
MIRT051651 UBN2 ubinuclein 2 1 1
MIRT051652 ZNF805 zinc finger protein 805 1 1
MIRT051653 RBBP4 RB binding protein 4, chromatin remodeling factor 1 1
MIRT051654 OCLN occludin 1 1
MIRT051655 CBX5 chromobox 5 2 3
MIRT051656 AMPD2 adenosine monophosphate deaminase 2 1 1
MIRT051657 MKI67 marker of proliferation Ki-67 1 1
MIRT051658 SUB1 SUB1 homolog, transcriptional regulator 1 1
MIRT051659 RSL1D1 ribosomal L1 domain containing 1 1 1
MIRT051660 SEC23IP SEC23 interacting protein 1 1
MIRT051661 RNMT RNA guanine-7 methyltransferase 1 1
MIRT051662 SGSM3 small G protein signaling modulator 3 1 1
MIRT051663 ZFP3 ZFP3 zinc finger protein 1 1
MIRT051664 GLUL glutamate-ammonia ligase 1 1
MIRT051665 POLD1 DNA polymerase delta 1, catalytic subunit 1 1
MIRT051666 WDR4 WD repeat domain 4 1 1
MIRT051667 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 1 1
MIRT051668 RAI2 retinoic acid induced 2 1 1
MIRT051669 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 1 1
MIRT051670 UTP15 UTP15, small subunit processome component 1 1
MIRT051671 THADA THADA, armadillo repeat containing 1 1
MIRT051672 ZNF451 zinc finger protein 451 1 1
MIRT051673 CREBBP CREB binding protein 1 1
MIRT051674 ZNF770 zinc finger protein 770 1 1
MIRT051675 CLDN4 claudin 4 1 1
MIRT051676 ZKSCAN7 zinc finger with KRAB and SCAN domains 7 1 1
MIRT051677 NICN1 nicolin 1 1 1
MIRT051678 RPLP2 ribosomal protein lateral stalk subunit P2 1 1
MIRT051679 DCBLD2 discoidin, CUB and LCCL domain containing 2 1 1
MIRT051680 IRGQ immunity related GTPase Q 1 1
MIRT051681 CA5B carbonic anhydrase 5B 1 1
MIRT051682 COX14 COX14, cytochrome c oxidase assembly factor 1 1
MIRT051683 PSD3 pleckstrin and Sec7 domain containing 3 1 1
MIRT051684 RPL27A ribosomal protein L27a 1 1
MIRT051685 CWC15 CWC15 spliceosome associated protein homolog 1 1
MIRT051686 NT5DC2 5'-nucleotidase domain containing 2 1 1
MIRT051687 OR7D2 olfactory receptor family 7 subfamily D member 2 1 1
MIRT051688 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 1 1
MIRT051689 NUDT15 nudix hydrolase 15 1 1
MIRT051690 CDH18 cadherin 18 1 1
MIRT051691 FAM160B1 family with sequence similarity 160 member B1 1 1
MIRT051692 DZIP1 DAZ interacting zinc finger protein 1 1 1
MIRT051693 TDRD7 tudor domain containing 7 1 1
MIRT051694 TCF4 transcription factor 4 1 1
MIRT051695 ENSA endosulfine alpha 1 1
MIRT051696 GTF3C1 general transcription factor IIIC subunit 1 1 1
MIRT051697 TNFRSF1A TNF receptor superfamily member 1A 1 1
MIRT051698 CCDC113 coiled-coil domain containing 113 1 1
MIRT051699 MYO9B myosin IXB 1 1
MIRT051700 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 1 1
MIRT051701 PRAMEF13 PRAME family member 13 1 1
MIRT051702 PMPCA peptidase, mitochondrial processing alpha subunit 2 5
MIRT051703 MRPS2 mitochondrial ribosomal protein S2 1 1
MIRT051704 RACGAP1 Rac GTPase activating protein 1 1 1
MIRT051705 CCDC106 coiled-coil domain containing 106 1 1
MIRT051706 CYP2B6 cytochrome P450 family 2 subfamily B member 6 1 1
MIRT051707 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 3
MIRT051708 PSME4 proteasome activator subunit 4 1 1
MIRT051709 SETD1A SET domain containing 1A 1 1
MIRT054561 MMP9 matrix metallopeptidase 9 3 1
MIRT054579 IGF1 insulin like growth factor 1 3 1
MIRT063195 ADIPOR2 adiponectin receptor 2 2 2
MIRT065687 ESPL1 extra spindle pole bodies like 1, separase 2 4
MIRT067399 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT068154 TXLNA taxilin alpha 2 2
MIRT068528 NHLRC3 NHL repeat containing 3 2 6
MIRT068789 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT073006 ARID3B AT-rich interaction domain 3B 2 6
MIRT076223 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT077616 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT080398 ONECUT2 one cut homeobox 2 2 2
MIRT083300 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084976 BACH1 BTB domain and CNC homolog 1 2 2
MIRT094160 PCGF3 polycomb group ring finger 3 2 6
MIRT094460 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT095766 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT100094 ABT1 activator of basal transcription 1 2 8
MIRT112242 MDM4 MDM4, p53 regulator 2 4
MIRT118586 STK4 serine/threonine kinase 4 2 2
MIRT120921 PDE12 phosphodiesterase 12 2 8
MIRT123317 CALU calumenin 2 2
MIRT152272 TNFSF9 TNF superfamily member 9 2 2
MIRT153847 NCOA3 nuclear receptor coactivator 3 2 2
MIRT168583 HMGA1 high mobility group AT-hook 1 2 4
MIRT180603 CRY2 cryptochrome circadian clock 2 2 2
MIRT187717 SUOX sulfite oxidase 2 2
MIRT191404 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193101 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215720 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT218815 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT240330 UBXN2B UBX domain protein 2B 2 2
MIRT243473 TRIM71 tripartite motif containing 71 2 2
MIRT244069 EDN1 endothelin 1 2 2
MIRT252330 SALL3 spalt like transcription factor 3 2 2
MIRT255314 CDV3 CDV3 homolog 2 2
MIRT259277 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT259479 TXLNG taxilin gamma 2 2
MIRT260707 CLDN12 claudin 12 2 6
MIRT264693 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT266212 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266626 CHTOP chromatin target of PRMT1 2 2
MIRT268839 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT294446 ZNF264 zinc finger protein 264 2 2
MIRT297013 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT297443 SLC20A1 solute carrier family 20 member 1 2 4
MIRT300037 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300893 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303320 MXD1 MAX dimerization protein 1 2 2
MIRT309846 NAT8L N-acetyltransferase 8 like 2 2
MIRT322428 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324731 ACER2 alkaline ceramidase 2 2 2
MIRT402057 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT437395 LIN28A lin-28 homolog A 4 1
MIRT437396 AURKB aurora kinase B 4 1
MIRT437435 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2 1
MIRT438632 TNFRSF10B TNF receptor superfamily member 10b 2 1
MIRT439135 MYC MYC proto-oncogene, bHLH transcription factor 0 1
MIRT442020 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT445658 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT447136 KIF27 kinesin family member 27 2 2
MIRT448259 ZNF774 zinc finger protein 774 2 2
MIRT449005 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449953 FMNL3 formin like 3 2 2
MIRT451155 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT451624 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451693 C1RL complement C1r subcomponent like 2 2
MIRT452092 NUCB2 nucleobindin 2 2 2
MIRT452431 QDPR quinoid dihydropteridine reductase 2 2
MIRT452943 DISC1 disrupted in schizophrenia 1 2 2
MIRT453401 RHD Rh blood group D antigen 2 6
MIRT454164 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT454280 FXN frataxin 2 2
MIRT454539 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454854 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455676 GLO1 glyoxalase I 2 2
MIRT457248 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457677 ZNF587 zinc finger protein 587 2 2
MIRT457887 THEM6 thioesterase superfamily member 6 2 4
MIRT458016 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458279 FUT10 fucosyltransferase 10 2 2
MIRT459736 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460453 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460500 FAM105A family with sequence similarity 105 member A 2 6
MIRT460938 NOA1 nitric oxide associated 1 2 4
MIRT461092 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461169 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461364 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462382 YAE1D1 Yae1 domain containing 1 2 2
MIRT462780 ZNF8 zinc finger protein 8 2 2
MIRT463420 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463662 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464265 VCL vinculin 2 2
MIRT465122 TSC22D2 TSC22 domain family member 2 2 4
MIRT466184 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466722 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469102 RNF144B ring finger protein 144B 2 2
MIRT469714 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470425 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT470679 POLR2D RNA polymerase II subunit D 2 4
MIRT470861 PLXND1 plexin D1 2 2
MIRT471271 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471957 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472672 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 2
MIRT472739 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473134 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473234 SMCR7L mitochondrial elongation factor 1 1 4
MIRT473828 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473940 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474022 LRRC20 leucine rich repeat containing 20 2 2
MIRT474502 KLHDC8B kelch domain containing 8B 2 2
MIRT474766 KIAA0930 KIAA0930 2 2
MIRT474905 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475331 IFNLR1 interferon lambda receptor 1 2 2
MIRT475379 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475733 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476548 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476973 FAM83G family with sequence similarity 83 member G 2 4
MIRT477534 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 4
MIRT477682 EFHD2 EF-hand domain family member D2 2 2
MIRT481201 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481241 ATXN7L3 ataxin 7 like 3 2 2
MIRT481363 ATG9A autophagy related 9A 2 2
MIRT481388 ATG12 autophagy related 12 2 2
MIRT481652 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481851 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482184 AHR aryl hydrocarbon receptor 2 2
MIRT482220 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT485296 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT486659 ZNF28 zinc finger protein 28 2 2
MIRT489413 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491867 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492216 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT492626 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT493323 LIMD2 LIM domain containing 2 2 2
MIRT493901 FAM43A family with sequence similarity 43 member A 2 4
MIRT494263 CEP120 centrosomal protein 120 2 2
MIRT494687 ARID3A AT-rich interaction domain 3A 2 2
MIRT495968 TBC1D19 TBC1 domain family member 19 2 2
MIRT496111 SNX17 sorting nexin 17 2 2
MIRT497875 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498122 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499405 PLCG2 phospholipase C gamma 2 2 4
MIRT499493 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499653 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499942 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT499997 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500819 THBS1 thrombospondin 1 2 3
MIRT500902 STRN striatin 2 4
MIRT501118 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501173 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501202 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501241 SEMA4C semaphorin 4C 2 6
MIRT501328 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501355 RNF44 ring finger protein 44 2 4
MIRT501387 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501441 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501759 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501943 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502106 KPNA5 karyopherin subunit alpha 5 2 8
MIRT502130 KMT2D lysine methyltransferase 2D 2 4
MIRT502784 CEP135 centrosomal protein 135 2 2
MIRT502845 CELF1 CUGBP Elav-like family member 1 2 2
MIRT504789 C12orf4 chromosome 12 open reading frame 4 2 2
MIRT505017 ZNF644 zinc finger protein 644 2 2
MIRT506942 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507252 FIGN fidgetin, microtubule severing factor 2 8
MIRT507694 COIL coilin 2 6
MIRT508401 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508665 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508932 AK4 adenylate kinase 4 2 4
MIRT510395 ZNF566 zinc finger protein 566 2 6
MIRT510518 YOD1 YOD1 deubiquitinase 2 6
MIRT511386 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512745 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515954 C9orf156 tRNA methyltransferase O 2 2
MIRT516083 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT523619 FZD9 frizzled class receptor 9 2 4
MIRT523733 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523990 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524113 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525727 SOD2 superoxide dismutase 2 2 2
MIRT527763 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529727 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533187 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536378 LEFTY1 left-right determination factor 1 2 2
MIRT543785 RBM12B RNA binding motif protein 12B 2 4
MIRT543868 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545387 PM20D2 peptidase M20 domain containing 2 2 2
MIRT545890 ZNF200 zinc finger protein 200 2 4
MIRT546334 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547373 MSI2 musashi RNA binding protein 2 2 2
MIRT547579 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT548264 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548351 EPHA4 EPH receptor A4 2 2
MIRT548534 DUSP1 dual specificity phosphatase 1 2 2
MIRT548560 DNAL1 dynein axonemal light chain 1 2 2
MIRT548779 COLEC12 collectin subfamily member 12 2 2
MIRT548978 CCNT2 cyclin T2 2 2
MIRT549208 BEND4 BEN domain containing 4 2 4
MIRT549763 ZNF611 zinc finger protein 611 2 6
MIRT549799 KIAA0391 KIAA0391 2 2
MIRT549847 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550898 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551283 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551318 GSG2 histone H3 associated protein kinase 2 6
MIRT551932 AKAP8 A-kinase anchoring protein 8 2 4
MIRT552003 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552410 ZNF460 zinc finger protein 460 2 4
MIRT553013 USP38 ubiquitin specific peptidase 38 2 2
MIRT555550 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555711 PDZD8 PDZ domain containing 8 2 2
MIRT557372 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT557960 FAM222B family with sequence similarity 222 member B 2 2
MIRT559087 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559497 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561772 PEG10 paternally expressed 10 2 2
MIRT564402 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565443 SURF4 surfeit 4 2 2
MIRT566518 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT567715 E2F6 E2F transcription factor 6 2 2
MIRT568655 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569498 THYN1 thymocyte nuclear protein 1 2 2
MIRT573820 TGOLN2 trans-golgi network protein 2 2 2
MIRT574363 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574750 GOLGA4 golgin A4 2 2
MIRT574788 FAM104A family with sequence similarity 104 member A 2 2
MIRT576089 Poteg POTE ankyrin domain family, member G 2 2
MIRT576812 Thbs1 thrombospondin 1 2 3
MIRT616370 RWDD1 RWD domain containing 1 2 2
MIRT617851 FMO4 flavin containing monooxygenase 4 2 2
MIRT642394 ZNF556 zinc finger protein 556 2 2
MIRT680519 PRIM2 DNA primase subunit 2 2 2
MIRT680547 ZNF584 zinc finger protein 584 2 2
MIRT680800 ZNF578 zinc finger protein 578 2 2
MIRT680838 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681141 INTS7 integrator complex subunit 7 2 2
MIRT681271 RFC2 replication factor C subunit 2 2 2
MIRT681323 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681359 BRI3BP BRI3 binding protein 2 2
MIRT681506 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681536 ZNF738 zinc finger protein 738 2 2
MIRT681658 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681738 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681797 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681869 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT681941 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682102 ITGA3 integrin subunit alpha 3 2 4
MIRT682181 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682238 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682384 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682444 MTX3 metaxin 3 2 2
MIRT682604 CPA4 carboxypeptidase A4 2 2
MIRT682640 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689327 FPR1 formyl peptide receptor 1 2 2
MIRT689730 ATXN2 ataxin 2 2 2
MIRT691036 ZNF799 zinc finger protein 799 2 2
MIRT691935 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694884 ZNF417 zinc finger protein 417 2 2
MIRT695255 ZNF443 zinc finger protein 443 2 2
MIRT695413 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700589 PRSS22 protease, serine 22 2 2
MIRT701428 NHLRC2 NHL repeat containing 2 2 2
MIRT702484 KIAA1328 KIAA1328 2 2
MIRT702715 IPO9 importin 9 2 2
MIRT704028 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704418 CTPS1 CTP synthase 1 2 2
MIRT705750 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712373 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713520 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT731263 FASLG Fas ligand 3 1
MIRT732697 Ccr7 chemokine (C-C motif) receptor 7 2 0
MIRT732700 Snhg12 small nucleolar RNA host gene 12 2 0
MIRT734626 SYT7 synaptotagmin 7 1 0
MIRT755829 UBQLN4 ubiquilin 4 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7e Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
let-7e Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7e Doxorubicin approved 31703 Microarray ovarian cancer 19237188 2009 up-regulated
let-7e 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7e Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 up-regulated
let-7e Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7e 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
let-7e Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
let-7e Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
let-7e Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7e 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
let-7e Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7e Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
let-7e 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
let-7e Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-let-7e Doxorubicin 31703 NSC123127 approved resistant High Ovarian Cancer cell line (OV19, TOV21G, TOV112D, FUOV1, C13, OV2008, A2780CP, A2780S, IGROV1, T8, OVCAR5, IMCC3, A2008, OVCAR3, SKOV3, IOSER)
hsa-let-7e Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7e Verapamil 2520 NSC272366 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7e Cisplatin 5460033 NSC119875 approved resistant High Tongue Squamous Cell Carcinoma cell line (Tca8113)
hsa-let-7e Fluorouracil 3385 NSC19893 approved resistant High Colon Cancer cell line (DLD-1)
hsa-let-7e Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer tissue and cell line (A2780)
hsa-let-7e Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-let-7e Paclitaxel 36314 NSC125973 approved sensitive High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-let-7e Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H1155, H358, H1993)
hsa-let-7e Doxorubicin 31703 NSC123127 approved sensitive Low Gastric Cancer cell line (SGC7901)
hsa-let-7e Vincristine 5978 approved sensitive Low Gastric Cancer cell line (SGC7901)
hsa-let-7e Gefitinib 123631 NSC715055 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-let-7e Imatinib 5291 NSC743414 approved resistant High Gastrointestinal Stromal Tumor tissue
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive High Esophageal Adenocarcinoma cell line (OE19)
hsa-let-7e Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer tissue and cell line (MCF-7)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-let-7e Plx-4720 24180719 NSC757438 resistant High Thyroid Cancer cell line (8505c, BCPAP)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-let-7e Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (DLD-1)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780, HO8910, ES2, CAOV3, SKOV3)
hsa-let-7e Fluorouracil 3385 NSC19893 approved sensitive Low Colorectal Cancer cell line (HCT-8)
hsa-let-7e Daunorubicin 30323 NSC82151 approved resistant High Acute Promyelocytic Leukemia cell line (HL60)
hsa-let-7e Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7C)
hsa-let-7e Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7e Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7e Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-let-7e Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-let-7e Gefitinib 123631 NSC715055 approved sensitive Low Colorectal Cancer cell line (HCT-116)
hsa-let-7e Regorafenib 11167602 NSC763932 approved sensitive Low Colorectal Cancer cell line (HCT-116)
hsa-let-7e Ribavirin+Pegylated IFNa-2b resistant tissue (chronic hepatitis C)
hsa-let-7e Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-let-7e 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7e Ethanol+Tamoxifen resistant cell line (LY2)
hsa-let-7e Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-let-7e Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-let-7e Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-let-7e Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-let-7e Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-let-7e Gemcitabine 60750 NSC613327 approved resistant cell line (HuH28)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive cell line (OE19)
hsa-let-7e Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-let-7e Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-let-7e Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-let-7e Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-let-7e Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)
hsa-let-7e Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-let-7e-5p Alvocidib 5287969 NSC649890 resistant
hsa-let-7e-5p Ethyl, methoxy, prodigisine 135829283 NSC742418 resistant
hsa-let-7e-5p Platinum 23939 resistant Low Ovarian Cancer tissue
hsa-let-7e-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-let-7e-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-let-7e-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-let-7e-5p Platinum 23939 resistant High High-Grade Serous Ovarian Cancer tissue
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-let-7e-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7e-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7e-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7e-5p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-let-7e-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-let-7e-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-let-7e-5p Sunitinib 5329102 NSC750690 approved sensitive tissue (clear cell renal cell carcinoma)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-let-7e-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-let-7e-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-let-7e-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)
hsa-let-7e-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

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