miRTarBase - #MIRT491970


—
pre-miRNA Information
pre-miRNA hsa-mir-4280   
Genomic Coordinates chr5: 87114879 - 87114954
Description Homo sapiens miR-4280 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4280
Sequence 11| GAGUGUAGUUCUGAGCAGAGC |31
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1267452683 6 dbSNP
rs921418201 13 dbSNP
rs975577876 15 dbSNP
rs562687273 20 dbSNP
rs968639930 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol USP37   
Synonyms -
Description ubiquitin specific peptidase 37
Transcript NM_020935   
Expression
Putative miRNA Targets on USP37
3'UTR of USP37
(miRNA target sites are highlighted)		 
>USP37|NM_020935|3'UTR
   1 GGAACAAACTCCTGGGTTGGCAGCATGCACTGCATATTTGTTACTGCTGCCCACCTCACCTTTCCTCTGCTGAAGGAGAA
  81 TTTGGAATTCTACTTGATGCGGGAGCAACAAACAGCTCAGGGCCAAACCAAAAGACAAAAATTGGAGTAACGTAGAATGC
 161 TCCATGCTATTTTATGGAAACTTTGGTCTCACATCCGTAGCTGATTATCCTCTTTTTCTCCTATGAGTGGCACTTCTTTT
 241 GTCTTAGGAATACATGTTGTAAATATATATCTGTGTATGTGTGTATACACACACACAGACACACACACACACACACGGGA
 321 TGAATGGAGCCTTAAAGAGTTAGGATGAGCCACCAGAATATGCCTGCTCAAAATTAATAGCACAGCAGTTTGGAGAAGAA
 401 ATGAAGGTGTCAAAGAGTCCATTCACCTGAGAAATGTGTGAAGACATACTTATCAGTTGGCTTTTAGCTTTTATGTTCCT
 481 TGAGTAGTTTCACTCAAGTCTGTAACCTTTTGTGTTTCCTTATTAGTAAAATTCACTGGAAAGCCAGCTCTTCATGTTAC
 561 ACTAATGACAGTTTGTTCTCTTTGCAAGAGAGGGGCATTACTGTCACCTGACTTGAGGAGCTGTTTTGTTGTTGTTGTTG
 641 TCTGCAAATTTCATGAATTTGTGATGTCTTTGCTGTTTACATGCAGTCCCAAGAAATGGATTGTTGGTGCTTTGGAATAT
 721 GTTACAGTCCCACATTTGATATTTCTTATATACTTTGTTTTCTCTAAGGAGATTTCTTCACACAGTATGTTCATCATATA
 801 TCATCATCATTATTATGGTGGTAAAGATAGAATCTTTTTTCTTTTTTGTCATTCTGCCATGGAGCAGCATTACCCTAATG
 881 GATTGCAACCAAAACTTTAAACAAGTAGAAAGATAATATTTCTCCAATTGGGACTCCCCAGCAGGAATACTTAGGGATAA
 961 GGAAGAATGCTAGCATCTCTGTCTCTCAAACATAGGGAGGATAAGAAGAGTGTTCTTCTGGTAAAGCTAAAATTCTGGAC
1041 CACTGAAGCTAAAAGCCCTATTGCAAGTATGAAATTAAGTACTTGAGCTGTAGGACAAACCTTGGGCATTTAACCATTTA
1121 CTGTCTGGCTTTGCCCTTAAAATAGGGTTGCAATTAAAATGTGATTGGCTTAGGTAATCCCAAAAACTAACAAATAACAA
1201 AGGTGCATAATTTATTTATCTACTTTTTAGGTGCTCTGAGTTGAGGCAAAGTAGAGCGGCAACATTAAGTGCTATGCTAG
1281 TCACTTAGCTGACGTAACCAGCTTGGTTAAGCAGCTTATGAAACCATATAAAGAATTCTTTTGAGGATGGAATTCTGTCC
1361 ACAAAATAATTTTGTGAGCCCAGATATCATTAGGATCACACAGAGTTAAATATAGAAAAATGAAACCATCATTATATTCT
1441 TTCGTGTTTTTTCTTTTATTATAAACAAGGGGATTATTCTTTAGTTCTCAGAGGTAGGGACAAAACCACATCAGGTTTTC
1521 AGAAGGAAAAAACATTTAAAAACCCACCATCACATGAGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGA
1601 GATCGCATCATTGCACTGCAGTCTGAGTGACAGAGTGAGACTCCATCTCATTAAAAAAAACGAAAACAAAAACAAAAAAA
1681 ACACAAACCATCATCACAGAAGATGCAACATCTTTTCTGAAAGATTGCCTTAAGAGAGCTCCAGTCCTACTCTTGGAACT
1761 TGGATGTATTCTAATGTAGTAAACTATTCTAAGTTTTCATTCTTTGAATTATAAATGGCCTCAGCAGTTTTGCTCAACTA
1841 CTGATAAATGCTTTGCCTCCTACCATCTACCTATATACCTTATTGTAATGAATGTTCCAAAATGGTAGAGTGGTAGAAAA
1921 CGCCAGAGTAGTTTAGAGCAGAGGAAAATATTTGTTTTAAAACTAGCTTTAAAGTTTTGTTTCATTTCTACCAGGAGCCT
2001 CTTTGGTTTGGTTTGATTTTGCTTGGAAATAATTGGTTTTCTTATAAATGAGTGAAGCGGTGATAAAATTCTTTGGCTAG
2081 TTATTAATTCTTTTACGTGTCTTTGCATTTGAGAGGCACTGTTAAAAATTATTGGGAAAGATTTAAAGTGCAGGCTGCAA
2161 TTAAAACATGGAGAAAAGTAGAAATAATGCCATAAGTCTAGATTGCCTCATGAAGCAGCCTCATTTGAATTGCTTTCATA
2241 GCTTTCATGTGTGTATGGTTTAGAAGTACACTTACCTCAGAAACCTGATTTGATCTTCATGTCTTGGGCAGGAGTTGTTG
2321 AAAATAGGTTATTGGAATATATAAGTTATCTCACTGCTCATGTACTTGCATGTTTGGGACTCAAATTTTACTTGATGTCT
2401 GTCCATTCTTGTGGCCCTATCAGCCTTCTCCTTCCTTTACTCCTTTAATCTACTTCTTTGACTACCAGTGGAGATTTCAG
2481 CTGGACTATGTTGATGGGGTTTGTTGTTGTTTTTGAGCTGGCTGTATATATTTTAAAATTATAAATAGATAATATATTAT
2561 TTTTTGCACATTGTGATCAGTTTGCCCAGAATTGGGGATGGGGCAGTTAGCATGTTGGGGCCAGGAAGGGACAAGTTAGA
2641 TAAGGACTGAGTGCTTCCGTTGCAGGCAGTTTGCACAATACCTAATTAACCTTCCTATTGAAAATACCAAATGTGTGGTT
2721 ACATTACTTTAAATGACATTGAATTGGAACTTGATGGCAATTAGTTCTAGATACAACCTTTTGATCTTTGTTGGAATTTT
2801 AAGGGAAAAATGAACTAAACTTCATATTTGTTGATTTTAATCACCTAATAGTACTGAAGGTTGGAAAGTTGCATGTGGCT
2881 GGATGCTGTTAATTTCTTTAATAGCCATGACTATAATTTAAGCCTATGAGAAGATAGACTGTTTCGTAGGGATATATTCA
2961 CATGTGTGTGCACACTCATGAGTTTTGTCTCAGCAGGATAGAATAAGCAAATCCATGAACTGGTCTTCTATTAATACTTT
3041 GATTCTAAAAATTATTTGTTTACTTGCTATGGTCTGTTCATTCTGGGCCTAACCTTAAAGGCTCAATAACAAATACAACA
3121 AATGTAAATATGTTTACATTTTAAGACATATGCAGTGGTTCTTACAGATCAGTTAATTAACTCCAGAAAGCAAATGTTAG
3201 ACTACACATTTATTTTTCTCCTTGATCAAGTATAAAATTCTGAAACAGAGGCTTTAAAATTTAAAACCTCAGCAAAATAA
3281 TCCATGAATTTACTGATTCTTCTGTATCGTGTGTAGTTACCATTATGTAACTATACACACATACAGCTACGGATATAATG
3361 AAAATTATCTGCAAACACCTAAATTAAAGAGAAAAAAAAGTAGTTTGTAAACTCATTTGTGATCTACTGAAAAGAGGTTA
3441 TATTAAAGCAAATTAAAATATTTTCCTTCTCTGTCCTCTGAAATGACTGCAGTAGATACTCTTAGTTATCCCATTTAGGG
3521 TGGTTGGAGGGCCTTTTTAATTTAATTGACCCCCCGAGGTGGTCTTTTGTTTTAAACAGGGGGCAACAGCTGGATCTCCA
3601 AGTACATATGGATTTTGTATATATAGGAGATTTTTAGAAAAATCAACAACCTAACACCAGATTCAAGTCACATAAAAGTG
3681 TTCCAATAAAATGGATGGATGTCTTTTTCCTCCCCATTTTGCTTTATACTGAGTAATGCACTCTTGCAAGTGTATACAAA
3761 AACTAAATAGACTTCTGCCCTCCAACATCTTTTTATTGCATTACTTCAAAATCCTAATTTTGTCTCTACTGATATGTCTT
3841 ATTAACATCTGAAAAAATATATATTTTTTATTGGAAAATTCTAATTTGTTAGGCCTTGAAAGTTTTGTGACAATTATTTT
3921 GCTGTGTTTAACCACAATCATTCACCTTATGGCATGCTTTGATTACTAGACTTCAGGCAGTCTCATTCATTGTATCATAC
4001 TTACACACAATTAGTAAGTTGTCTCCATGTGTGCTATATGTCTGAGGTGTATGGAGTTTTTATTTAAAAAGTGTGCCAGT
4081 CTGAATATAAGCATTTGATTTTGTAACATTGGACTTTTCTTAAAAGTACAGAGGTTCAAAGTATAGGTATGTCCATTGGC
4161 ATAAGAATAGAGTGGGTGAGGGTCTGGACCAGGTTCCAGGTTGGTCCAGTCAGATGCCAGAACAAAGAAGAACAGTCAAC
4241 TAAACTGGTCTACTTCAAAAATAGTGGGCCTGTGTGAAGAGTGAGACCACATGTGGGTGTGCACACCTCTTGTCCCCAGG
4321 TTTCCCTCCCTTTGAGCTTTTCTTTCCCTCCCTAACTTCTCTGGCCTATTGTCATTGTTGTTTCTTTAAACTTAAGGAGA
4401 GAAAAACAAAAATGAGATTCCTACACTTTGCCTAATTGAGCCACTACCAGGTTTTCTGGCAGCTGTGGCCACATTATTTG
4481 TGAGATGATTTTTTTTCTTTATGTTCAGAGTGACTTTTGATTCTGATTCTTTATGTTTTGTATGGAGCGGCACTTTTATC
4561 TGTGTTTTAGCAGAACTGTTCCTCTGTATCCTTTACGGTTTTTCTTTGTTTTTGTTTCCTTTTTAAATTATGCATAGAGT
4641 TTTTTTGTGTGTATGAAATTAAAGCCTTTATTAACCTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgagacgAGUCU--UGAUGUGAg 5'
                 | |||   ||||||| 
Target 5' acaaaaaTGAGATTCCTACACTt 3'
 4406 - 4428 144.00 -10.10
2 
miRNA  3' cgagaCGAGUCUUGAUGUGAg 5'
               |:|:|||| |||||| 
Target 5' gtatgGTTTAGAAGTACACTt 3'
 2253 - 2273 140.00 -17.20
3 
miRNA  3' cgaGACGAGUCUUGAUGUGAg 5'
             || :|||  ::|||||| 
Target 5' cagCTCTTCA-TGTTACACTa 3'
 545 - 564 137.00 -13.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31598569 27 COSMIC
COSN30490012 36 COSMIC
COSN30491950 46 COSMIC
COSN27004391 76 COSMIC
COSN13971264 100 COSMIC
COSN30512829 104 COSMIC
COSN30512819 134 COSMIC
COSN30166059 176 COSMIC
COSN30473675 191 COSMIC
COSN30543173 220 COSMIC
COSN18723813 286 COSMIC
COSN31561705 286 COSMIC
COSN20074513 298 COSMIC
COSN31778269 298 COSMIC
COSN23353255 299 COSMIC
COSN26599310 424 COSMIC
COSN31518349 606 COSMIC
COSN31561826 617 COSMIC
COSN31548518 762 COSMIC
COSN31569617 776 COSMIC
COSN30175322 805 COSMIC
COSN31571515 830 COSMIC
COSN20090726 1027 COSMIC
COSN19042152 1070 COSMIC
COSN22565611 1556 COSMIC
COSN22840394 1968 COSMIC
COSN22679351 2001 COSMIC
COSN15103035 2023 COSMIC
COSN17913385 2405 COSMIC
COSN16875607 2460 COSMIC
COSN20780416 2670 COSMIC
COSN23417266 2750 COSMIC
COSN7798414 3028 COSMIC
COSN26639236 3116 COSMIC
COSN22374978 3152 COSMIC
COSN21308917 3153 COSMIC
COSN20097828 3353 COSMIC
COSN6169636 3381 COSMIC
COSN1825255 3756 COSMIC
COSN29235827 3764 COSMIC
COSN23741619 4006 COSMIC
COSN32166780 4044 COSMIC
COSN31555455 4488 COSMIC
COSN26568360 4497 COSMIC
COSN31524452 4549 COSMIC
COSN30543408 4550 COSMIC
COSN25701525 4630 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1277245918 3 dbSNP
rs1375256911 4 dbSNP
rs573420333 8 dbSNP
rs764470500 11 dbSNP
rs758805691 12 dbSNP
rs558062861 15 dbSNP
rs753040443 16 dbSNP
rs765834170 17 dbSNP
rs200160968 25 dbSNP
rs1160170677 27 dbSNP
rs776210160 28 dbSNP
rs765750756 30 dbSNP
rs1182431622 36 dbSNP
rs1483605537 40 dbSNP
rs896597455 40 dbSNP
rs755225957 41 dbSNP
rs1489513227 42 dbSNP
rs760427920 43 dbSNP
rs1194827973 44 dbSNP
rs1047149641 45 dbSNP
rs773037740 47 dbSNP
rs1189740499 58 dbSNP
rs929926924 71 dbSNP
rs1419142858 72 dbSNP
rs186991645 92 dbSNP
rs1156869992 95 dbSNP
rs1471170897 96 dbSNP
rs183065253 99 dbSNP
rs979674918 100 dbSNP
rs537807728 101 dbSNP
rs567391701 102 dbSNP
rs1314276045 110 dbSNP
rs1489964732 114 dbSNP
rs150043486 115 dbSNP
rs527380599 136 dbSNP
rs1023623917 138 dbSNP
rs911034889 140 dbSNP
rs1014034555 141 dbSNP
rs566698382 151 dbSNP
rs955145916 152 dbSNP
rs139514714 157 dbSNP
rs1311826868 160 dbSNP
rs1255726566 163 dbSNP
rs960795251 164 dbSNP
rs533257880 167 dbSNP
rs988582708 173 dbSNP
rs1015442075 176 dbSNP
rs1257446747 178 dbSNP
rs1439240782 180 dbSNP
rs1176845462 185 dbSNP
rs1382418322 193 dbSNP
rs1440482025 194 dbSNP
rs763103426 196 dbSNP
rs1358311821 197 dbSNP
rs1221599899 214 dbSNP
rs886950402 224 dbSNP
rs1032691707 225 dbSNP
rs1304582250 241 dbSNP
rs1352164514 242 dbSNP
rs73990483 246 dbSNP
rs759937668 252 dbSNP
rs1222809254 262 dbSNP
rs1378692780 265 dbSNP
rs969667463 267 dbSNP
rs1023800840 269 dbSNP
rs6750261 273 dbSNP
rs1212682919 275 dbSNP
rs769616490 276 dbSNP
rs1457667825 277 dbSNP
rs1196836698 279 dbSNP
rs1240060812 281 dbSNP
rs896654105 290 dbSNP
rs1026123969 292 dbSNP
rs1039314694 294 dbSNP
rs1423290506 295 dbSNP
rs868134487 296 dbSNP
rs1177895377 298 dbSNP
rs865998188 298 dbSNP
rs398042878 299 dbSNP
rs1429910175 303 dbSNP
rs878999393 308 dbSNP
rs994275352 310 dbSNP
rs1328711606 313 dbSNP
rs375360609 316 dbSNP
rs879428281 316 dbSNP
rs1292657176 317 dbSNP
rs1442257309 317 dbSNP
rs71403040 317 dbSNP
rs781468133 317 dbSNP
rs912272057 317 dbSNP
rs1220911713 324 dbSNP
rs1245215504 328 dbSNP
rs1052618900 329 dbSNP
rs935131555 331 dbSNP
rs925441940 334 dbSNP
rs979620994 336 dbSNP
rs1269270688 338 dbSNP
rs1477359031 342 dbSNP
rs942620395 352 dbSNP
rs552308481 364 dbSNP
rs916848735 366 dbSNP
rs751974632 372 dbSNP
rs1410103773 375 dbSNP
rs889736800 382 dbSNP
rs1176413312 383 dbSNP
rs1479742572 406 dbSNP
rs1431957358 411 dbSNP
rs1200577940 426 dbSNP
rs1475263628 427 dbSNP
rs748176322 434 dbSNP
rs933781034 437 dbSNP
rs1213131949 439 dbSNP
rs1340354423 446 dbSNP
rs1398509091 453 dbSNP
rs1280723700 462 dbSNP
rs1340604684 469 dbSNP
rs1448237582 483 dbSNP
rs780794874 495 dbSNP
rs1005374416 525 dbSNP
rs1056901580 526 dbSNP
rs1026760376 531 dbSNP
rs749485578 533 dbSNP
rs374680005 536 dbSNP
rs899735005 542 dbSNP
rs199827133 554 dbSNP
rs1285061040 556 dbSNP
rs1191224213 560 dbSNP
rs1007857418 566 dbSNP
rs1265268943 568 dbSNP
rs1475663677 578 dbSNP
rs1180808309 580 dbSNP
rs1223921826 596 dbSNP
rs1406579219 614 dbSNP
rs373269909 621 dbSNP
rs778308559 621 dbSNP
rs1359492619 623 dbSNP
rs890776706 631 dbSNP
rs1418266870 640 dbSNP
rs747879235 642 dbSNP
rs61497664 645 dbSNP
rs935060158 647 dbSNP
rs903635955 652 dbSNP
rs1043891132 653 dbSNP
rs992440563 662 dbSNP
rs193040043 664 dbSNP
rs948221780 665 dbSNP
rs1408973092 666 dbSNP
rs573256010 670 dbSNP
rs1025839763 689 dbSNP
rs916796429 702 dbSNP
rs1214186613 705 dbSNP
rs150968427 725 dbSNP
rs1447540327 733 dbSNP
rs1409753791 734 dbSNP
rs898621817 736 dbSNP
rs1016885248 739 dbSNP
rs1184479839 740 dbSNP
rs939653596 742 dbSNP
rs1437391629 743 dbSNP
rs1160846131 745 dbSNP
rs746629068 749 dbSNP
rs1414228946 750 dbSNP
rs779707943 751 dbSNP
rs983500942 766 dbSNP
rs1361389211 779 dbSNP
rs1248160197 786 dbSNP
rs1006814166 787 dbSNP
rs1308543658 792 dbSNP
rs1375001726 793 dbSNP
rs1182469960 796 dbSNP
rs1409847202 808 dbSNP
rs1280339035 811 dbSNP
rs546041687 814 dbSNP
rs1218425640 817 dbSNP
rs1459557192 818 dbSNP
rs1276491367 822 dbSNP
rs575912033 826 dbSNP
rs1462544736 827 dbSNP
rs1203786837 830 dbSNP
rs1456051386 832 dbSNP
rs557659107 835 dbSNP
rs1364011960 839 dbSNP
rs1027713149 841 dbSNP
rs1171123502 848 dbSNP
rs1306759545 848 dbSNP
rs1270621928 850 dbSNP
rs1216590992 851 dbSNP
rs1330796496 856 dbSNP
rs973837081 857 dbSNP
rs758082930 859 dbSNP
rs536135377 865 dbSNP
rs963851146 868 dbSNP
rs1051430831 873 dbSNP
rs1018138929 875 dbSNP
rs1008561724 886 dbSNP
rs1272815503 904 dbSNP
rs1325612439 911 dbSNP
rs1224099918 912 dbSNP
rs891071157 915 dbSNP
rs573713374 916 dbSNP
rs1197015288 923 dbSNP
rs999205637 928 dbSNP
rs1450614195 930 dbSNP
rs555392170 936 dbSNP
rs935728542 941 dbSNP
rs373107592 952 dbSNP
rs1480957617 958 dbSNP
rs1442100510 959 dbSNP
rs142568397 961 dbSNP
rs925658042 963 dbSNP
rs116720220 976 dbSNP
rs1168511769 981 dbSNP
rs895309212 989 dbSNP
rs1325747597 990 dbSNP
rs188858285 995 dbSNP
rs1277548615 999 dbSNP
rs1338254894 1010 dbSNP
rs939585530 1015 dbSNP
rs1355238358 1019 dbSNP
rs1162455744 1020 dbSNP
rs908131225 1029 dbSNP
rs1490635071 1030 dbSNP
rs758278509 1041 dbSNP
rs983833813 1043 dbSNP
rs1026228458 1059 dbSNP
rs1261675112 1060 dbSNP
rs972962028 1060 dbSNP
rs1244428389 1061 dbSNP
rs1368017040 1067 dbSNP
rs745361752 1075 dbSNP
rs1182438922 1082 dbSNP
rs1456428552 1088 dbSNP
rs9646856 1090 dbSNP
rs920644344 1097 dbSNP
rs1206394646 1101 dbSNP
rs1342563922 1106 dbSNP
rs974788468 1108 dbSNP
rs1291325188 1110 dbSNP
rs1358578972 1117 dbSNP
rs139425266 1121 dbSNP
rs796303662 1123 dbSNP
rs1339410924 1128 dbSNP
rs1241979317 1129 dbSNP
rs778585092 1138 dbSNP
rs1018508872 1150 dbSNP
rs1359638632 1153 dbSNP
rs540244280 1162 dbSNP
rs1313490916 1168 dbSNP
rs1487039883 1169 dbSNP
rs1206282329 1172 dbSNP
rs954018714 1177 dbSNP
rs955443202 1182 dbSNP
rs1030938817 1185 dbSNP
rs1386096047 1187 dbSNP
rs1439270784 1193 dbSNP
rs1157853183 1194 dbSNP
rs998492942 1201 dbSNP
rs376742070 1202 dbSNP
rs999153472 1204 dbSNP
rs767953161 1206 dbSNP
rs1300374487 1207 dbSNP
rs1443387617 1209 dbSNP
rs1365274507 1220 dbSNP
rs1302208070 1232 dbSNP
rs967715589 1234 dbSNP
rs1022004713 1237 dbSNP
rs1306589235 1254 dbSNP
rs755415130 1257 dbSNP
rs1053452472 1258 dbSNP
rs894924155 1268 dbSNP
rs1405746488 1270 dbSNP
rs550487422 1272 dbSNP
rs904374617 1274 dbSNP
rs59696280 1293 dbSNP
rs184157897 1302 dbSNP
rs866758601 1306 dbSNP
rs1177050639 1307 dbSNP
rs1267904045 1311 dbSNP
rs1410436952 1315 dbSNP
rs1220624406 1316 dbSNP
rs1490895330 1317 dbSNP
rs1377004912 1323 dbSNP
rs766686395 1326 dbSNP
rs1215194299 1333 dbSNP
rs1315135251 1342 dbSNP
rs1047972528 1346 dbSNP
rs1309800105 1378 dbSNP
rs1229530029 1379 dbSNP
rs561796393 1383 dbSNP
rs920591880 1386 dbSNP
rs1281735238 1397 dbSNP
rs1039035950 1399 dbSNP
rs1392334510 1402 dbSNP
rs1056836796 1404 dbSNP
rs80085898 1405 dbSNP
rs528597759 1417 dbSNP
rs1310975941 1421 dbSNP
rs1225943518 1433 dbSNP
rs1264269935 1438 dbSNP
rs1317448441 1442 dbSNP
rs911996365 1444 dbSNP
rs1452439177 1446 dbSNP
rs1234828551 1453 dbSNP
rs1481044549 1458 dbSNP
rs1177602700 1463 dbSNP
rs1266351199 1467 dbSNP
rs564391273 1473 dbSNP
rs955238580 1479 dbSNP
rs773158964 1487 dbSNP
rs868464670 1489 dbSNP
rs765361428 1494 dbSNP
rs1429889740 1496 dbSNP
rs1464660656 1497 dbSNP
rs923820547 1498 dbSNP
rs1167614354 1501 dbSNP
rs1355946570 1502 dbSNP
rs1161275790 1507 dbSNP
rs962829392 1508 dbSNP
rs977996086 1510 dbSNP
rs1292557512 1513 dbSNP
rs561268002 1521 dbSNP
rs1428389863 1522 dbSNP
rs1197037756 1524 dbSNP
rs1284551693 1536 dbSNP
rs546400211 1538 dbSNP
rs1212886796 1545 dbSNP
rs1268322714 1553 dbSNP
rs1308327295 1571 dbSNP
rs954151847 1574 dbSNP
rs4674310 1575 dbSNP
rs563857718 1580 dbSNP
rs1489815030 1585 dbSNP
rs959359329 1587 dbSNP
rs1269519928 1588 dbSNP
rs542585762 1591 dbSNP
rs1034778845 1594 dbSNP
rs1004083374 1599 dbSNP
rs886599538 1604 dbSNP
rs1323427528 1605 dbSNP
rs1163721699 1606 dbSNP
rs1426966866 1607 dbSNP
rs776649478 1612 dbSNP
rs1360485004 1628 dbSNP
rs956237150 1631 dbSNP
rs550993339 1636 dbSNP
rs1362828624 1637 dbSNP
rs1227795640 1641 dbSNP
rs1225773532 1645 dbSNP
rs1313204737 1645 dbSNP
rs995029698 1647 dbSNP
rs1331977654 1648 dbSNP
rs1224479189 1650 dbSNP
rs75279097 1651 dbSNP
rs1031563343 1653 dbSNP
rs34459693 1653 dbSNP
rs1381290874 1655 dbSNP
rs899455255 1661 dbSNP
rs377138273 1662 dbSNP
rs1475491019 1668 dbSNP
rs943404005 1675 dbSNP
rs754570453 1677 dbSNP
rs904342304 1678 dbSNP
rs1044272848 1679 dbSNP
rs1447980180 1682 dbSNP
rs147013574 1682 dbSNP
rs1174095792 1684 dbSNP
rs1399315913 1684 dbSNP
rs867552889 1685 dbSNP
rs1346246399 1686 dbSNP
rs1470841253 1693 dbSNP
rs1012666144 1697 dbSNP
rs1192826097 1698 dbSNP
rs1334733521 1702 dbSNP
rs555404335 1703 dbSNP
rs1057294171 1704 dbSNP
rs371987568 1709 dbSNP
rs1308758647 1727 dbSNP
rs1349773624 1739 dbSNP
rs1221848325 1740 dbSNP
rs1447444247 1764 dbSNP
rs928949888 1767 dbSNP
rs1240678951 1770 dbSNP
rs1462255153 1771 dbSNP
rs1264002310 1773 dbSNP
rs533511216 1775 dbSNP
rs368062145 1782 dbSNP
rs941646001 1783 dbSNP
rs934775922 1784 dbSNP
rs923796450 1786 dbSNP
rs1174872997 1789 dbSNP
rs1408438878 1800 dbSNP
rs1288575939 1811 dbSNP
rs1453464786 1812 dbSNP
rs977943667 1818 dbSNP
rs967928237 1820 dbSNP
rs985633622 1821 dbSNP
rs1439761751 1825 dbSNP
rs750168106 1830 dbSNP
rs1281031838 1832 dbSNP
rs915179516 1838 dbSNP
rs1226291813 1840 dbSNP
rs1305379571 1845 dbSNP
rs1299304086 1851 dbSNP
rs922671683 1856 dbSNP
rs1271852231 1857 dbSNP
rs1435191666 1859 dbSNP
rs1184453451 1865 dbSNP
rs990446166 1867 dbSNP
rs1233867219 1873 dbSNP
rs1381326987 1875 dbSNP
rs1238277845 1876 dbSNP
rs959077586 1880 dbSNP
rs1197969020 1883 dbSNP
rs977258292 1887 dbSNP
rs191906272 1889 dbSNP
rs557537666 1897 dbSNP
rs1169978533 1904 dbSNP
rs1035130517 1907 dbSNP
rs1394644716 1913 dbSNP
rs147830999 1914 dbSNP
rs768396275 1921 dbSNP
rs1336173141 1922 dbSNP
rs746788783 1926 dbSNP
rs539496174 1927 dbSNP
rs1347247357 1928 dbSNP
rs1223623944 1932 dbSNP
rs968659415 1935 dbSNP
rs878927236 1936 dbSNP
rs1460236440 1937 dbSNP
rs994981585 1938 dbSNP
rs755451033 1947 dbSNP
rs1490304908 1951 dbSNP
rs115806209 1958 dbSNP
rs771710877 1968 dbSNP
rs895642707 1974 dbSNP
rs1444103278 1979 dbSNP
rs1241343614 1994 dbSNP
rs1371462615 1995 dbSNP
rs1476417121 2005 dbSNP
rs745541398 2010 dbSNP
rs550360466 2011 dbSNP
rs1168782757 2025 dbSNP
rs1035422883 2032 dbSNP
rs1423767834 2038 dbSNP
rs1052239157 2040 dbSNP
rs1301016384 2045 dbSNP
rs1367391258 2048 dbSNP
rs1405535657 2054 dbSNP
rs1294731889 2055 dbSNP
rs934744386 2058 dbSNP
rs1228955189 2059 dbSNP
rs897478693 2065 dbSNP
rs1358202630 2068 dbSNP
rs1443468344 2071 dbSNP
rs1250317807 2072 dbSNP
rs111763032 2077 dbSNP
rs1042220072 2078 dbSNP
rs946534839 2085 dbSNP
rs1481784544 2090 dbSNP
rs567976270 2096 dbSNP
rs756815929 2097 dbSNP
rs1193903239 2111 dbSNP
rs888733716 2115 dbSNP
rs1358184986 2118 dbSNP
rs1442951793 2131 dbSNP
rs748563630 2131 dbSNP
rs147356323 2132 dbSNP
rs932811363 2137 dbSNP
rs1288273701 2141 dbSNP
rs867719530 2142 dbSNP
rs922774452 2149 dbSNP
rs867235460 2153 dbSNP
rs545181962 2157 dbSNP
rs1328057194 2162 dbSNP
rs1243378454 2177 dbSNP
rs570803726 2179 dbSNP
rs1372118593 2180 dbSNP
rs1238767153 2181 dbSNP
rs1259502172 2190 dbSNP
rs552424878 2192 dbSNP
rs924601521 2200 dbSNP
rs1383512389 2202 dbSNP
rs751957692 2205 dbSNP
rs1473140296 2207 dbSNP
rs1363732154 2208 dbSNP
rs1180209972 2209 dbSNP
rs1185731090 2212 dbSNP
rs1243958819 2214 dbSNP
rs1424190147 2219 dbSNP
rs1158021261 2220 dbSNP
rs1362025042 2222 dbSNP
rs1421310351 2228 dbSNP
rs531016032 2234 dbSNP
rs186236147 2248 dbSNP
rs1404776748 2249 dbSNP
rs1449834273 2249 dbSNP
rs1338366394 2251 dbSNP
rs1379375940 2255 dbSNP
rs763428829 2262 dbSNP
rs968711831 2265 dbSNP
rs150960542 2272 dbSNP
rs544226141 2272 dbSNP
rs1337877694 2275 dbSNP
rs766916313 2292 dbSNP
rs1490077137 2293 dbSNP
rs1240434779 2306 dbSNP
rs1289075041 2325 dbSNP
rs542393471 2328 dbSNP
rs1026040645 2341 dbSNP
rs1321573973 2344 dbSNP
rs1356359315 2349 dbSNP
rs1205574099 2350 dbSNP
rs1263993983 2354 dbSNP
rs1480408253 2356 dbSNP
rs1176433187 2360 dbSNP
rs1248210829 2361 dbSNP
rs973505315 2362 dbSNP
rs530425267 2375 dbSNP
rs959874676 2384 dbSNP
rs142875571 2397 dbSNP
rs3755042 2405 dbSNP
rs1177888825 2408 dbSNP
rs1359400269 2410 dbSNP
rs182183587 2411 dbSNP
rs1007806924 2427 dbSNP
rs1015876312 2428 dbSNP
rs1283217116 2429 dbSNP
rs1325697295 2433 dbSNP
rs1225465436 2446 dbSNP
rs1283952948 2450 dbSNP
rs1306970607 2450 dbSNP
rs1202745613 2452 dbSNP
rs750668413 2464 dbSNP
rs765178958 2468 dbSNP
rs1481529279 2488 dbSNP
rs1384328728 2497 dbSNP
rs765587641 2503 dbSNP
rs999279790 2528 dbSNP
rs1268106432 2530 dbSNP
rs903227924 2535 dbSNP
rs542994834 2542 dbSNP
rs947486283 2544 dbSNP
rs893638655 2569 dbSNP
rs1427401614 2596 dbSNP
rs545629009 2606 dbSNP
rs1479637019 2608 dbSNP
rs190152795 2615 dbSNP
rs1430807796 2616 dbSNP
rs574950541 2629 dbSNP
rs1302882333 2638 dbSNP
rs937928224 2639 dbSNP
rs185340913 2648 dbSNP
rs927885382 2654 dbSNP
rs1041647213 2658 dbSNP
rs371156182 2659 dbSNP
rs1361444203 2669 dbSNP
rs1200481712 2675 dbSNP
rs1298019973 2677 dbSNP
rs1343060147 2690 dbSNP
rs1228912445 2699 dbSNP
rs928979028 2715 dbSNP
rs924653901 2717 dbSNP
rs1290822444 2718 dbSNP
rs1451738108 2719 dbSNP
rs1224710276 2722 dbSNP
rs1282941643 2723 dbSNP
rs1485267154 2730 dbSNP
rs1184187971 2736 dbSNP
rs918975485 2737 dbSNP
rs978841818 2738 dbSNP
rs1383821881 2740 dbSNP
rs568037201 2744 dbSNP
rs1324852525 2752 dbSNP
rs1345061690 2757 dbSNP
rs75065977 2764 dbSNP
rs1222707119 2765 dbSNP
rs991411167 2771 dbSNP
rs1343346281 2774 dbSNP
rs1276888942 2776 dbSNP
rs1357079722 2778 dbSNP
rs1229761242 2781 dbSNP
rs1290513319 2786 dbSNP
rs910702527 2788 dbSNP
rs1213060870 2794 dbSNP
rs1243396485 2798 dbSNP
rs1464932912 2803 dbSNP
rs1182670174 2808 dbSNP
rs1325965769 2825 dbSNP
rs986733495 2826 dbSNP
rs1316280575 2840 dbSNP
rs776610182 2842 dbSNP
rs1164133546 2844 dbSNP
rs972341586 2860 dbSNP
rs553954224 2867 dbSNP
rs1161871887 2868 dbSNP
rs1031001591 2869 dbSNP
rs534233951 2872 dbSNP
rs760676053 2873 dbSNP
rs1015942218 2878 dbSNP
rs568356575 2893 dbSNP
rs1174040799 2901 dbSNP
rs534903395 2908 dbSNP
rs1449991664 2913 dbSNP
rs1005939066 2914 dbSNP
rs1028639122 2924 dbSNP
rs997103374 2925 dbSNP
rs1329315794 2926 dbSNP
rs1478134223 2930 dbSNP
rs879232100 2935 dbSNP
rs1260873492 2940 dbSNP
rs768124017 2945 dbSNP
rs555293423 2946 dbSNP
rs373049013 2947 dbSNP
rs999387868 2954 dbSNP
rs1413263899 2957 dbSNP
rs903371573 2961 dbSNP
rs1043135939 2963 dbSNP
rs1202942661 2964 dbSNP
rs1408601869 2964 dbSNP
rs1310287349 2965 dbSNP
rs760259869 2968 dbSNP
rs947484418 2973 dbSNP
rs1290153599 2978 dbSNP
rs1350965095 2979 dbSNP
rs1056239120 3000 dbSNP
rs1011646943 3011 dbSNP
rs938604981 3013 dbSNP
rs1418716594 3015 dbSNP
rs894591389 3019 dbSNP
rs1200739707 3020 dbSNP
rs775201478 3023 dbSNP
rs1271829740 3040 dbSNP
rs1002467506 3047 dbSNP
rs1436442516 3063 dbSNP
rs79871636 3066 dbSNP
rs1046754162 3067 dbSNP
rs1480367962 3071 dbSNP
rs771869997 3079 dbSNP
rs1268595640 3083 dbSNP
rs774809983 3085 dbSNP
rs1478394552 3093 dbSNP
rs929260874 3096 dbSNP
rs918921622 3103 dbSNP
rs1037353415 3105 dbSNP
rs941772531 3106 dbSNP
rs910307334 3107 dbSNP
rs1365951290 3119 dbSNP
rs1404314036 3120 dbSNP
rs986275116 3124 dbSNP
rs1332372858 3128 dbSNP
rs1233264201 3148 dbSNP
rs961823449 3151 dbSNP
rs536439724 3152 dbSNP
rs1231101026 3155 dbSNP
rs1275859800 3160 dbSNP
rs1490279632 3165 dbSNP
rs552539465 3168 dbSNP
rs1335254813 3171 dbSNP
rs1270081292 3178 dbSNP
rs1452271295 3183 dbSNP
rs955052658 3191 dbSNP
rs1240615891 3197 dbSNP
rs1451510760 3202 dbSNP
rs984486533 3205 dbSNP
rs1409704375 3213 dbSNP
rs531028149 3216 dbSNP
rs1161604516 3220 dbSNP
rs1392707065 3222 dbSNP
rs1028647859 3229 dbSNP
rs1997210 3232 dbSNP
rs1324151969 3251 dbSNP
rs977667418 3252 dbSNP
rs1166259590 3268 dbSNP
rs967643784 3271 dbSNP
rs1021620620 3283 dbSNP
rs999122604 3289 dbSNP
rs1244168702 3290 dbSNP
rs1011595988 3292 dbSNP
rs1390247282 3299 dbSNP
rs1357625681 3304 dbSNP
rs1204655873 3306 dbSNP
rs1182951455 3308 dbSNP
rs1482220864 3309 dbSNP
rs1239080914 3311 dbSNP
rs903340358 3313 dbSNP
rs958753922 3321 dbSNP
rs1043273515 3322 dbSNP
rs1034853290 3331 dbSNP
rs1002011950 3333 dbSNP
rs538154391 3336 dbSNP
rs1242695486 3338 dbSNP
rs906354150 3344 dbSNP
rs2178019 3350 dbSNP
rs201481658 3351 dbSNP
rs200950433 3352 dbSNP
rs199545933 3353 dbSNP
rs869035782 3357 dbSNP
rs201152095 3358 dbSNP
rs3046871 3358 dbSNP
rs5838697 3358 dbSNP
rs200332132 3360 dbSNP
rs1458347087 3366 dbSNP
rs1320826469 3372 dbSNP
rs1343047725 3384 dbSNP
rs1314431023 3385 dbSNP
rs1244488729 3389 dbSNP
rs1381999170 3391 dbSNP
rs530286746 3392 dbSNP
rs1381503223 3395 dbSNP
rs1450956270 3399 dbSNP
rs1341427983 3400 dbSNP
rs938644621 3400 dbSNP
rs1239013741 3402 dbSNP
rs1441943127 3403 dbSNP
rs1353104069 3407 dbSNP
rs1209358983 3419 dbSNP
rs928672162 3426 dbSNP
rs1460108808 3442 dbSNP
rs769318777 3455 dbSNP
rs940635743 3458 dbSNP
rs1424171855 3468 dbSNP
rs1181069282 3474 dbSNP
rs897776658 3476 dbSNP
rs559873675 3479 dbSNP
rs1037302411 3483 dbSNP
rs941701649 3494 dbSNP
rs181614464 3503 dbSNP
rs1404932239 3505 dbSNP
rs774084894 3510 dbSNP
rs984620613 3514 dbSNP
rs1050590348 3532 dbSNP
rs933124157 3533 dbSNP
rs1305495488 3536 dbSNP
rs923413242 3550 dbSNP
rs977613464 3554 dbSNP
rs1421499904 3555 dbSNP
rs1415877063 3556 dbSNP
rs975873569 3556 dbSNP
rs1182316175 3559 dbSNP
rs190356504 3579 dbSNP
rs774587884 3580 dbSNP
rs748809605 3581 dbSNP
rs1483491980 3586 dbSNP
rs1249569041 3588 dbSNP
rs1483968486 3594 dbSNP
rs990112859 3619 dbSNP
rs1428041304 3623 dbSNP
rs958968354 3632 dbSNP
rs1219511032 3637 dbSNP
rs1177868869 3649 dbSNP
rs1021794542 3658 dbSNP
rs1461821267 3667 dbSNP
rs1323512515 3679 dbSNP
rs1306503912 3682 dbSNP
rs186692529 3693 dbSNP
rs1034390258 3703 dbSNP
rs776864873 3705 dbSNP
rs1365653233 3709 dbSNP
rs57984500 3709 dbSNP
rs981933360 3710 dbSNP
rs1349058667 3712 dbSNP
rs1290569932 3716 dbSNP
rs1307097128 3734 dbSNP
rs1226452743 3739 dbSNP
rs1410765939 3751 dbSNP
rs763589266 3754 dbSNP
rs777482165 3756 dbSNP
rs182566436 3768 dbSNP
rs575013554 3771 dbSNP
rs1024751504 3776 dbSNP
rs1344003964 3777 dbSNP
rs1034825540 3781 dbSNP
rs993305123 3782 dbSNP
rs1487219176 3786 dbSNP
rs907178790 3796 dbSNP
rs1267634846 3800 dbSNP
rs1036360167 3805 dbSNP
rs1165480075 3808 dbSNP
rs1400012074 3817 dbSNP
rs1392487074 3822 dbSNP
rs1409545661 3823 dbSNP
rs897724399 3824 dbSNP
rs1430790119 3826 dbSNP
rs1016141758 3832 dbSNP
rs1348581572 3834 dbSNP
rs1438742734 3844 dbSNP
rs1472775068 3845 dbSNP
rs887659277 3847 dbSNP
rs1433223904 3849 dbSNP
rs1006127460 3852 dbSNP
rs1048967117 3858 dbSNP
rs751164316 3858 dbSNP
rs1344123769 3859 dbSNP
rs1228800775 3860 dbSNP
rs1289095377 3863 dbSNP
rs888776927 3864 dbSNP
rs1268455495 3865 dbSNP
rs1189636775 3870 dbSNP
rs1223641589 3870 dbSNP
rs1265556542 3872 dbSNP
rs1050119978 3873 dbSNP
rs1186344072 3879 dbSNP
rs1249439926 3883 dbSNP
rs1450485587 3886 dbSNP
rs1183328001 3887 dbSNP
rs1412294830 3888 dbSNP
rs931790830 3902 dbSNP
rs921800120 3907 dbSNP
rs976226093 3910 dbSNP
rs1489543562 3913 dbSNP
rs944497966 3918 dbSNP
rs115287645 3920 dbSNP
rs901603855 3924 dbSNP
rs879156471 3937 dbSNP
rs552367739 3947 dbSNP
rs1270532658 3950 dbSNP
rs1313328951 3952 dbSNP
rs1229399727 3953 dbSNP
rs1345207755 3956 dbSNP
rs541502643 3960 dbSNP
rs574582033 3961 dbSNP
rs914794757 3982 dbSNP
rs1236131509 3992 dbSNP
rs1473977673 3998 dbSNP
rs1183014869 3999 dbSNP
rs532538913 4008 dbSNP
rs1293583204 4009 dbSNP
rs1407805067 4018 dbSNP
rs1471656839 4018 dbSNP
rs1429357009 4020 dbSNP
rs140637939 4036 dbSNP
rs959098617 4038 dbSNP
rs1034545707 4040 dbSNP
rs937650137 4041 dbSNP
rs1003366922 4063 dbSNP
rs907318458 4071 dbSNP
rs1449874409 4079 dbSNP
rs1014968219 4088 dbSNP
rs1004798591 4097 dbSNP
rs1226073534 4107 dbSNP
rs758809227 4109 dbSNP
rs1329210922 4110 dbSNP
rs1218337469 4113 dbSNP
rs1276057745 4116 dbSNP
rs865899671 4134 dbSNP
rs534655870 4141 dbSNP
rs1251774531 4149 dbSNP
rs570677607 4161 dbSNP
rs1435102542 4170 dbSNP
rs558690333 4175 dbSNP
rs1480149405 4176 dbSNP
rs1171043053 4185 dbSNP
rs537406962 4191 dbSNP
rs1415983794 4208 dbSNP
rs1334519752 4210 dbSNP
rs190373350 4211 dbSNP
rs1407972083 4218 dbSNP
rs1025703407 4223 dbSNP
rs1463547499 4229 dbSNP
rs1250458949 4230 dbSNP
rs1435039502 4232 dbSNP
rs931948508 4233 dbSNP
rs971836713 4235 dbSNP
rs900317264 4239 dbSNP
rs548725085 4245 dbSNP
rs1208008338 4248 dbSNP
rs566586635 4249 dbSNP
rs536726803 4261 dbSNP
rs1253083959 4262 dbSNP
rs1451123850 4269 dbSNP
rs1196787645 4272 dbSNP
rs944447903 4280 dbSNP
rs923680349 4287 dbSNP
rs961844484 4291 dbSNP
rs1313611898 4295 dbSNP
rs566180370 4295 dbSNP
rs1016089533 4296 dbSNP
rs546360518 4303 dbSNP
rs1006532708 4304 dbSNP
rs1170414844 4307 dbSNP
rs1371023945 4311 dbSNP
rs11543953 4312 dbSNP
rs1404262232 4313 dbSNP
rs1042163539 4319 dbSNP
rs113721181 4326 dbSNP
rs914925576 4327 dbSNP
rs1435682534 4332 dbSNP
rs990381004 4336 dbSNP
rs1276004399 4354 dbSNP
rs959025290 4356 dbSNP
rs775555883 4357 dbSNP
rs750567639 4361 dbSNP
rs757482622 4368 dbSNP
rs1378428277 4370 dbSNP
rs1169935630 4373 dbSNP
rs1004934286 4375 dbSNP
rs1190211733 4377 dbSNP
rs1373601050 4377 dbSNP
rs1447794880 4387 dbSNP
rs1457393460 4391 dbSNP
rs780960910 4394 dbSNP
rs1392344020 4397 dbSNP
rs1405374663 4413 dbSNP
rs1319489199 4415 dbSNP
rs1041497368 4420 dbSNP
rs1437766624 4432 dbSNP
rs1298853702 4436 dbSNP
rs945815262 4440 dbSNP
rs1027636854 4443 dbSNP
rs370645896 4448 dbSNP
rs1461246690 4449 dbSNP
rs116105206 4465 dbSNP
rs1357143863 4473 dbSNP
rs1202584260 4478 dbSNP
rs772180476 4484 dbSNP
rs927581869 4485 dbSNP
rs1008691982 4487 dbSNP
rs1256244894 4489 dbSNP
rs1227196390 4496 dbSNP
rs1046122902 4499 dbSNP
rs1262241884 4502 dbSNP
rs1339545142 4508 dbSNP
rs1299147393 4510 dbSNP
rs1423027765 4512 dbSNP
rs1185338831 4519 dbSNP
rs1370062198 4519 dbSNP
rs902366842 4525 dbSNP
rs950083915 4533 dbSNP
rs1228426125 4535 dbSNP
rs1157722280 4545 dbSNP
rs1042132461 4548 dbSNP
rs946479105 4549 dbSNP
rs565541205 4556 dbSNP
rs14998 4559 dbSNP
rs1310402097 4562 dbSNP
rs914907599 4570 dbSNP
rs1336730501 4575 dbSNP
rs1106412 4596 dbSNP
rs1286571363 4597 dbSNP
rs1331311868 4598 dbSNP
rs1229318478 4605 dbSNP
rs1255565945 4611 dbSNP
rs972788284 4635 dbSNP
rs962791403 4636 dbSNP
rs1198466850 4640 dbSNP
rs1402626913 4644 dbSNP
rs1258220769 4645 dbSNP
rs1181337036 4647 dbSNP
rs1485981666 4647 dbSNP
rs1307729494 4651 dbSNP
rs1473284086 4653 dbSNP
rs1159382737 4660 dbSNP
rs1376657597 4665 dbSNP
rs760551266 4670 dbSNP
rs1174633405 4672 dbSNP
rs1376409273 4675 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgaGACGAGUCUUGAUGUGAg 5'
             || :|||  ::|||||| 
Target 5' cagCUCUUCA-UGUUACACUa 3'
 		2 - 21
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000258399.3 | 3UTR | CCAGCUCUUCAUGUUACACUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4280 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT065612 DAZAP2 DAZ associated protein 2 2 10
MIRT084985 BACH1 BTB domain and CNC homolog 1 2 2
MIRT088053 UBXN2A UBX domain protein 2A 2 4
MIRT097327 SCAMP1 secretory carrier membrane protein 1 2 2
MIRT099148 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT127042 FAM208B family with sequence similarity 208 member B 2 4
MIRT140479 BNIP2 BCL2 interacting protein 2 2 6
MIRT154889 GNAS GNAS complex locus 2 4
MIRT187983 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT190440 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT240673 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT295049 EVI5L ecotropic viral integration site 5 like 2 2
MIRT324749 ACER2 alkaline ceramidase 2 2 2
MIRT366075 FAM127A retrotransposon Gag like 8C 2 4
MIRT442625 LOX lysyl oxidase 2 2
MIRT445224 TYRP1 tyrosinase related protein 1 2 2
MIRT448967 CCNT2 cyclin T2 2 4
MIRT450137 PFN4 profilin family member 4 2 2
MIRT464350 USP46 ubiquitin specific peptidase 46 2 2
MIRT470460 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT473691 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT480188 CALM2 calmodulin 2 2 6
MIRT486355 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT486708 TROVE2 TROVE domain family member 2 2 4
MIRT488337 SCD stearoyl-CoA desaturase 2 2
MIRT489322 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT491791 ZNF24 zinc finger protein 24 2 2
MIRT491970 USP37 ubiquitin specific peptidase 37 2 2
MIRT492029 TWF1 twinfilin actin binding protein 1 2 4
MIRT492063 TMEM245 transmembrane protein 245 2 2
MIRT492247 SLC39A9 solute carrier family 39 member 9 2 2
MIRT492254 SLC35F5 solute carrier family 35 member F5 2 2
MIRT492592 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493436 KAT7 lysine acetyltransferase 7 2 2
MIRT493470 IPMK inositol polyphosphate multikinase 2 2
MIRT493639 HECTD1 HECT domain E3 ubiquitin protein ligase 1 2 2
MIRT493919 FAM127B retrotransposon Gag like 8A 2 4
MIRT494639 ARNTL aryl hydrocarbon receptor nuclear translocator like 2 2
MIRT500032 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT504589 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 4
MIRT505535 SP4 Sp4 transcription factor 2 6
MIRT507539 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 6
MIRT508846 TMCO1 transmembrane and coiled-coil domains 1 2 4
MIRT510488 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT511402 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT523252 HIST1H2AH histone cluster 1 H2A family member h 2 2
MIRT525939 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT531453 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT533317 UNKL unkempt family like zinc finger 2 2
MIRT541034 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT546734 RNF217 ring finger protein 217 2 2
MIRT555125 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT556105 MOAP1 modulator of apoptosis 1 2 2
MIRT560205 AK4 adenylate kinase 4 2 2
MIRT561087 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT566967 LBR lamin B receptor 2 2
MIRT567344 H3F3B H3 histone family member 3B 2 2
MIRT567863 DCAF12 DDB1 and CUL4 associated factor 12 2 2
MIRT574449 SCML2 Scm polycomb group protein like 2 2 2
MIRT575700 Map1b microtubule-associated protein 1B 2 2
MIRT651432 YIPF6 Yip1 domain family member 6 2 2
MIRT659728 CCDC93 coiled-coil domain containing 93 2 2
MIRT686937 SFT2D3 SFT2 domain containing 3 2 2
MIRT699385 SLC30A6 solute carrier family 30 member 6 2 2
MIRT710287 CSNK1G3 casein kinase 1 gamma 3 2 2
MIRT715123 PANK3 pantothenate kinase 3 2 2
MIRT721847 VLDLR very low density lipoprotein receptor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4280 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4280 Platinum 23939 resistant tissue
hsa-miR-4280 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4280 Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4280 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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