miRTarBase - #MIRT492341


—
pre-miRNA Information
pre-miRNA hsa-mir-4707   
Genomic Coordinates chr14: 22956950 - 22957029
Description Homo sapiens miR-4707 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4707-3p
Sequence 52| AGCCCGCCCCAGCCGAGGUUCU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1180125593 2 dbSNP
rs1390998288 5 dbSNP
rs2273626 6 dbSNP
rs765507627 7 dbSNP
rs1299611135 9 dbSNP
rs1158707105 11 dbSNP
rs535691977 15 dbSNP
rs952013388 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SEPT8   
Synonyms SEP2
Description septin 8
Transcript NM_001098813   
Other Transcripts NM_001098811 , NM_001098812 , NM_015146   
Expression
Putative miRNA Targets on SEPT8
3'UTR of SEPT8
(miRNA target sites are highlighted)		 
>SEPT8|NM_001098813|3'UTR
   1 CGCACGCACAGACTTACATGTCAAGAGTGGACTTTAGACTTTCATGTGTTAAGTTGCTTGAGTTACACCTTGTGACCCTT
  81 CTCCCATAACATGGTGTGAGGACGGACTGGGAGCCGGTACAGACTCCAGTGTTTACAGCCTTGCTTTCCTCCCACCGACC
 161 CTGGCCCCAGGCTGCCCCGGGCCTGGCGGGCCACCCCTCTCTATGCAAACACGTAAAAGCCATGAATGCTGGAATCCAAA
 241 ACTGACGAGGTTTATTTTTTTCAGAGCCAGTGGCTGGTCTTCCATTTACAGTGTCACTATTCCCTGACGGAGCTGTTATG
 321 TGCCGCTCTAGCGAAGGCCCCAGCCGGGATGCTAGGCCTAATTGTTCAGCGTGGAGATGGCAACTCACGTGGTGCCCTAG
 401 GTGCAGCTGCGTGGTCTGGTATACATGCTGCAAAATTCACCCAGTTCCCCTCATTTTAATTTTTCTAACCTACAGCTTAA
 481 TTTTAATAACTTTAAAACACTTCTAAATATTTATTTTGGCACCAGCGTCAAGACAAATAATATCCTCTCCCATTATTTTC
 561 ATAAGTAACACAGATTCCCTGATTTTTAAAAACTAAAAATACAGCTAAACCTTTCTTATGTATAAAGTATGCCTATCATA
 641 TACAGGGAGAGGTGGGTAATAAACTTCCTGTAATGACAGTGTTTGGCATTTCTTTATGGATGGAATTGGAACATGAACAA
 721 GACCATGTCCAGCGTTTTTACTGTGAATGTAAATGGAACAGCAGCCCAAAGCTGTTGTCTGTGCCCCAGAGGTGCTACCT
 801 GTAGACAGGGACCAACTCCATGTGTGTGTGTTAAGTGTTTGACTCCAATTAAGACTCCCAAGCAAATCCTGCATATTCCA
 881 AATGTAAAGAGTACTCAGTGGGAAAAAGGTTGTTACCTCAAAGTCATTGCTTCTTTCCTGGCTGGGTCACAGGGTGAAGA
 961 GATGAAGGTGTCTGATGTATATAGACAATTAGGGAAAAATGAGCGGCAAAGGAGCTTTCCCCTTCAGCTGCACTCTAAAG
1041 GGGAACATTTTAAGGAAGTACTAGCAGCTTTGACTCTTCTATGCTCCTGTTGGTTTACAAGCCACCAAGAATGTCAGTGT
1121 TGAGAATACGGCCTGGTAAAATGGGAGATGTAAAATGACTAAATGAAAGGAAGGGTAGTTTTAATGTTGAAGCACCGTGC
1201 TGGGCACTGGAGCTACCCAGAGGAATGCACAACGCTCCCCTCAAGGAGCTCACAGTCTAGCCTACTCCCTGGCTGGAAGC
1281 CTCAGGAAGACGTGCTAATTTATTGTGGAATTGGTAGTTTGCTTTTCATGCCCCTGTCTTCCTTCTCATGACCATTTCCC
1361 CCTTTCTGTCTGGCTTGCATTATTGATTTCCAGGACCAAGTCCTGGCTTCCTCCTGCCTTCCTGAGATGATGTTCTGCTC
1441 AGGGAGAAGTGGAGGGGTGAGCTGTGTGTGTCCACCGAGGCACGGCCAGGAAGAGGCAGCCTTTACCTGTGAGGGGCTCC
1521 ATGCTCCAGCAGCAGAGCAGGTTCTAGTGACAATTCAACTTTTTATGCTATGACCAGGGGTGGATCTAAATTTTATGGGG
1601 CTGAAAGCTTGAATTATTTAGAAAGACTTCTTTAAGAAAAACAATGTTAATATAAAATTAGGTACAGGGTCTTGGAAGGG
1681 GCCCTGAAGATTAAGCTTCCTTAGCGTCACAATAAGTCCGTATCTGGTTGCAATTGAAAACTGATGCTTCAGTGAGGGTA
1761 TCTAAAAAGGTAAACTGGCATATCCAGGGCAAATGTGGGCTGCCAATGGCTCATCTCTAGGGTAATTTTATGTCTGAAAG
1841 TGTATGCAGTTGGGTCAGAGCATGACCTTTAAGATAGCCTCTCTCAGCTAACATATTTATGAAGATGAGGCCTGGTGACC
1921 CAGCAGGTTCATTGGATACATAAGAAATGAGAATTCCTGGTTCATGGGCCAACCTAGGACTCTGGAGTATGCAGACTTGG
2001 CCATTCGTCCATTGTGGCCTGCGGGTCGCACCCCAGGCATACTGAAAGGCCATACTCGTGGCTGGCTGCCTGCGGGCCTA
2081 AGCCTTCCCAGGATCTTCAGGACACTTGACAGACTTGTGTTTTCTGGTCTGAGCTGCCTCCACAGGTCCCTCCAGCAAGC
2161 CTCACTGCACCTCTCCCCTGCTGTTTGTGTTTGGAATTTTGTCTTCTTTAGCTGAGACCAAATTAAACCTTGGTGCATAA
2241 AGTGAGCTTAAAACTTGCCACTGTTTAGTAAGTTAGCCCCCATAGAATGTGACCCTGTCTGCAGAGTCTCATTTACCCCT
2321 CTTTTTCTCATTGTCATTTGTTGGCTTTATTAGGGCTGTCTTACAGGATCATGTTGGCATTTACTATCATGTCTTTATCA
2401 TAAACCATGTTTGTTTGAGGTAGAAGAATCACCATATAATTCGTTGCCCAAATTGGGACTATTGAGAGAGAAAGGGGATG
2481 CTATTAATTACACCAGATCAAAAGGCATAAACCAGACCTGTCCCAGGCCGATGTGGAAATATGTTCTTTCTAGTTGTGGG
2561 TACCCTGATCTAGGTGGTTTGTAATTGTGCATTACTGACTGCATATGTTTGTGTATGTGTAAATGTGGGCTCCCTGTTAA
2641 GTGGGGCTCATGGATACGAGGCCTGAGGAAGTGTGGCTTGCTAGTCTGTTACGTTAACATGCTTTTCTAAAATTGCTTCA
2721 CGTGTTAATTCATTTACTCCTGCATTCATTGACTGTTTTTGTTCTTTTCCATTCACTTTGTACTTATTTTTTTCATTAAA
2801 TTTTGCATTTATTTTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuUGGAGCC--GACCCCGCCCGa 5'
             :|| |||  ||  ||||||| 
Target 5' gctGCCCCGGGCCT--GGCGGGCc 3'
 171 - 192 153.00 -22.30
2 
miRNA  3' ucUUGGAGCCGACC-----CCGCCCGa 5'
            | :| :||||||      |||||| 
Target 5' atACTCGTGGCTGGCTGCCTGCGGGCc 3'
 2052 - 2078 128.00 -23.10
3 
miRNA  3' ucuuggagCCGACCCCGCCCGa 5'
                  ||  | ||:|||: 
Target 5' catatacaGGGAGAGGTGGGTa 3'
 637 - 658 114.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14139286 5 COSMIC
COSN26994301 6 COSMIC
COSN30522236 74 COSMIC
COSN25844121 109 COSMIC
COSN30177438 139 COSMIC
COSN30463775 159 COSMIC
COSN16048956 177 COSMIC
COSN20075421 178 COSMIC
COSN30137575 186 COSMIC
COSN31561770 187 COSMIC
COSN30160852 232 COSMIC
COSN6510365 278 COSMIC
COSN29513287 295 COSMIC
COSN30147748 309 COSMIC
COSN31612493 309 COSMIC
COSN30190797 314 COSMIC
COSN9405951 317 COSMIC
COSN30495131 320 COSMIC
COSN20065041 324 COSMIC
COSN30577529 333 COSMIC
COSN30153922 344 COSMIC
COSN26600982 373 COSMIC
COSN30686725 426 COSMIC
COSN31604314 475 COSMIC
COSN7875107 1335 COSMIC
COSN29164333 1429 COSMIC
COSN20091244 1461 COSMIC
COSN16410991 1519 COSMIC
COSN2484356 1552 COSMIC
COSN9405950 1662 COSMIC
COSN19580999 2057 COSMIC
COSN20876204 2517 COSMIC
COSN21155265 2716 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs112034900 1 dbSNP
rs773481967 2 dbSNP
rs375350369 5 dbSNP
rs372336901 6 dbSNP
rs1010171691 9 dbSNP
rs758435889 11 dbSNP
rs760390656 13 dbSNP
rs774531721 17 dbSNP
rs769079993 19 dbSNP
rs745449399 26 dbSNP
rs780897495 35 dbSNP
rs770631330 40 dbSNP
rs1421328543 42 dbSNP
rs750014078 43 dbSNP
rs746502815 44 dbSNP
rs758289330 45 dbSNP
rs867413623 62 dbSNP
rs1246040565 66 dbSNP
rs1389689298 70 dbSNP
rs1302033541 87 dbSNP
rs563821966 92 dbSNP
rs1032851554 95 dbSNP
rs1001734563 102 dbSNP
rs114375386 103 dbSNP
rs1309043466 104 dbSNP
rs1045497345 109 dbSNP
rs1445392310 112 dbSNP
rs1309241262 114 dbSNP
rs1019272806 115 dbSNP
rs1013955997 116 dbSNP
rs1348128283 121 dbSNP
rs533547472 122 dbSNP
rs1030759633 126 dbSNP
rs1292275615 135 dbSNP
rs770303754 141 dbSNP
rs1036677688 149 dbSNP
rs1469001420 150 dbSNP
rs1216966051 153 dbSNP
rs57510773 156 dbSNP
rs116236254 157 dbSNP
rs1444917239 167 dbSNP
rs1182366419 169 dbSNP
rs34160017 169 dbSNP
rs1367684677 172 dbSNP
rs115784309 178 dbSNP
rs932811532 179 dbSNP
rs1012483496 180 dbSNP
rs1464687733 181 dbSNP
rs922724475 182 dbSNP
rs559262204 187 dbSNP
rs542261704 188 dbSNP
rs1397107516 194 dbSNP
rs1174133114 199 dbSNP
rs940705801 199 dbSNP
rs913916463 212 dbSNP
rs370098786 213 dbSNP
rs2286012 216 dbSNP
rs778510246 220 dbSNP
rs1286215157 222 dbSNP
rs754805472 223 dbSNP
rs930755969 224 dbSNP
rs200179947 228 dbSNP
rs766692872 229 dbSNP
rs1303691115 230 dbSNP
rs761025294 232 dbSNP
rs750491567 237 dbSNP
rs767730032 238 dbSNP
rs774927929 246 dbSNP
rs769113406 247 dbSNP
rs1196239188 250 dbSNP
rs1432101377 262 dbSNP
rs1255374565 264 dbSNP
rs942624064 269 dbSNP
rs1202260526 270 dbSNP
rs373829311 274 dbSNP
rs1285806986 276 dbSNP
rs1217804458 277 dbSNP
rs202034103 278 dbSNP
rs1254496232 279 dbSNP
rs775884538 284 dbSNP
rs1162058927 286 dbSNP
rs770543424 288 dbSNP
rs746692668 290 dbSNP
rs182822481 293 dbSNP
rs771580046 294 dbSNP
rs1338291331 295 dbSNP
rs1297421799 296 dbSNP
rs371815283 299 dbSNP
rs1425227486 300 dbSNP
rs778905137 304 dbSNP
rs754926113 305 dbSNP
rs17716311 308 dbSNP
rs756356897 309 dbSNP
rs1030728705 311 dbSNP
rs979164372 314 dbSNP
rs1024086655 317 dbSNP
rs1477166937 318 dbSNP
rs374823905 319 dbSNP
rs370894893 320 dbSNP
rs557556946 324 dbSNP
rs377670560 325 dbSNP
rs1200114819 326 dbSNP
rs1005592048 332 dbSNP
rs764642987 333 dbSNP
rs767083820 334 dbSNP
rs1228223976 340 dbSNP
rs761303590 342 dbSNP
rs763413094 344 dbSNP
rs775788652 345 dbSNP
rs760259103 346 dbSNP
rs1331930451 348 dbSNP
rs960956288 350 dbSNP
rs1035686307 351 dbSNP
rs1191131761 353 dbSNP
rs772852321 353 dbSNP
rs771688591 355 dbSNP
rs747681296 358 dbSNP
rs754448107 362 dbSNP
rs11538383 364 dbSNP
rs1050423061 369 dbSNP
rs932850103 370 dbSNP
rs1345892980 371 dbSNP
rs376081226 378 dbSNP
rs1473559969 380 dbSNP
rs534762956 389 dbSNP
rs1376515730 392 dbSNP
rs566040915 394 dbSNP
rs1181266379 398 dbSNP
rs1475414387 404 dbSNP
rs371784308 408 dbSNP
rs73787063 410 dbSNP
rs1300708973 411 dbSNP
rs1329344465 421 dbSNP
rs1198390838 426 dbSNP
rs535469405 429 dbSNP
rs913947483 441 dbSNP
rs1352772442 444 dbSNP
rs942530938 448 dbSNP
rs1287842283 451 dbSNP
rs989534540 452 dbSNP
rs958269171 457 dbSNP
rs1486002472 466 dbSNP
rs1190212559 470 dbSNP
rs912458032 471 dbSNP
rs1434393836 474 dbSNP
rs570064454 484 dbSNP
rs980406122 486 dbSNP
rs1396188472 487 dbSNP
rs1419526790 488 dbSNP
rs1327784583 501 dbSNP
rs78253221 508 dbSNP
rs42403 519 dbSNP
rs1014064452 523 dbSNP
rs755941164 526 dbSNP
rs1015757858 527 dbSNP
rs1005252640 531 dbSNP
rs967817884 543 dbSNP
rs141229787 561 dbSNP
rs990966323 564 dbSNP
rs1237805214 565 dbSNP
rs548018527 569 dbSNP
rs1028598533 577 dbSNP
rs997067538 579 dbSNP
rs1455706600 587 dbSNP
rs1317223140 588 dbSNP
rs1220461352 605 dbSNP
rs1387912348 617 dbSNP
rs961171553 618 dbSNP
rs1213742591 619 dbSNP
rs1236995893 622 dbSNP
rs1439648546 627 dbSNP
rs1177254949 634 dbSNP
rs1158350825 635 dbSNP
rs528142897 639 dbSNP
rs190094653 645 dbSNP
rs35711958 648 dbSNP
rs1185098201 649 dbSNP
rs1366900847 657 dbSNP
rs1463172718 665 dbSNP
rs945544766 669 dbSNP
rs1399564128 670 dbSNP
rs1444480215 692 dbSNP
rs892584270 696 dbSNP
rs1373860843 700 dbSNP
rs1227509062 706 dbSNP
rs542750210 708 dbSNP
rs185978374 709 dbSNP
rs1233474723 714 dbSNP
rs1256888756 718 dbSNP
rs1456025876 724 dbSNP
rs1190035107 726 dbSNP
rs767496509 731 dbSNP
rs562974414 733 dbSNP
rs948627059 734 dbSNP
rs543286969 742 dbSNP
rs1027603776 754 dbSNP
rs757137806 762 dbSNP
rs112655906 768 dbSNP
rs1165840560 771 dbSNP
rs1423091386 772 dbSNP
rs576376724 775 dbSNP
rs564379372 776 dbSNP
rs58900866 778 dbSNP
rs1447153746 782 dbSNP
rs1300891822 794 dbSNP
rs984259530 801 dbSNP
rs1357069119 804 dbSNP
rs1415027288 809 dbSNP
rs1277162509 813 dbSNP
rs1006696561 818 dbSNP
rs890941472 821 dbSNP
rs1050939780 822 dbSNP
rs780199631 832 dbSNP
rs935234790 843 dbSNP
rs1255851399 848 dbSNP
rs57619465 854 dbSNP
rs1188994288 859 dbSNP
rs30534 864 dbSNP
rs996428257 866 dbSNP
rs901471974 868 dbSNP
rs946379822 874 dbSNP
rs1019815237 891 dbSNP
rs763037658 893 dbSNP
rs1413857246 907 dbSNP
rs1326610970 908 dbSNP
rs1202543089 910 dbSNP
rs1377120969 917 dbSNP
rs1435076663 919 dbSNP
rs1392759977 923 dbSNP
rs916312008 935 dbSNP
rs990960551 944 dbSNP
rs1457224923 963 dbSNP
rs1270284133 968 dbSNP
rs960508887 968 dbSNP
rs535971373 969 dbSNP
rs1219226842 970 dbSNP
rs1373379108 973 dbSNP
rs1278798185 976 dbSNP
rs1009717726 977 dbSNP
rs928131946 982 dbSNP
rs1212005416 988 dbSNP
rs892608437 990 dbSNP
rs1445521634 993 dbSNP
rs1053932603 995 dbSNP
rs116635281 1004 dbSNP
rs905245009 1005 dbSNP
rs1477738963 1010 dbSNP
rs1447245768 1016 dbSNP
rs556611775 1022 dbSNP
rs1045094301 1033 dbSNP
rs765010000 1056 dbSNP
rs949363923 1057 dbSNP
rs1358325623 1058 dbSNP
rs1402088575 1070 dbSNP
rs1453893677 1076 dbSNP
rs1318562652 1077 dbSNP
rs1348851902 1089 dbSNP
rs775888088 1090 dbSNP
rs865850603 1092 dbSNP
rs116262959 1098 dbSNP
rs57250316 1101 dbSNP
rs1373871380 1105 dbSNP
rs1235597214 1106 dbSNP
rs574275887 1108 dbSNP
rs1348906117 1113 dbSNP
rs1277148647 1116 dbSNP
rs1207190737 1124 dbSNP
rs1285206706 1128 dbSNP
rs148599916 1129 dbSNP
rs1341679584 1130 dbSNP
rs1254912424 1132 dbSNP
rs1304314357 1146 dbSNP
rs1235513775 1154 dbSNP
rs999360844 1166 dbSNP
rs1177856894 1174 dbSNP
rs1329352422 1176 dbSNP
rs1471031952 1181 dbSNP
rs755682788 1182 dbSNP
rs568673789 1193 dbSNP
rs145942790 1195 dbSNP
rs1043675127 1196 dbSNP
rs747547350 1197 dbSNP
rs1386099028 1199 dbSNP
rs1394505582 1203 dbSNP
rs975081176 1210 dbSNP
rs964999834 1216 dbSNP
rs1331260208 1217 dbSNP
rs1334420183 1222 dbSNP
rs1019846407 1228 dbSNP
rs1280459038 1230 dbSNP
rs10477743 1231 dbSNP
rs562913024 1233 dbSNP
rs747478324 1234 dbSNP
rs543025901 1237 dbSNP
rs1468961033 1243 dbSNP
rs532808462 1253 dbSNP
rs374890976 1254 dbSNP
rs1197997524 1255 dbSNP
rs1032934336 1257 dbSNP
rs1221926112 1259 dbSNP
rs1439385138 1261 dbSNP
rs1182296597 1262 dbSNP
rs1236634147 1275 dbSNP
rs1427480851 1276 dbSNP
rs1001004089 1291 dbSNP
rs1166570104 1295 dbSNP
rs905316291 1297 dbSNP
rs1464640755 1300 dbSNP
rs1045166154 1328 dbSNP
rs1478726696 1331 dbSNP
rs113009732 1335 dbSNP
rs561405899 1336 dbSNP
rs1438856395 1341 dbSNP
rs1329982886 1348 dbSNP
rs965019085 1358 dbSNP
rs1413238383 1364 dbSNP
rs142213206 1383 dbSNP
rs1254465208 1407 dbSNP
rs1203421588 1424 dbSNP
rs1482882899 1425 dbSNP
rs768076740 1428 dbSNP
rs1036341633 1435 dbSNP
rs1218060352 1438 dbSNP
rs1249649867 1439 dbSNP
rs1341417170 1440 dbSNP
rs1196247925 1442 dbSNP
rs1281317861 1450 dbSNP
rs1202339676 1451 dbSNP
rs1189704527 1452 dbSNP
rs541348432 1455 dbSNP
rs939939838 1459 dbSNP
rs1018013476 1462 dbSNP
rs6895457 1464 dbSNP
rs1463980424 1472 dbSNP
rs256871 1476 dbSNP
rs931152380 1477 dbSNP
rs921039439 1483 dbSNP
rs540935176 1484 dbSNP
rs446560 1493 dbSNP
rs576619365 1494 dbSNP
rs965073397 1503 dbSNP
rs999329582 1504 dbSNP
rs751989783 1507 dbSNP
rs1328208661 1509 dbSNP
rs1228153094 1515 dbSNP
rs1369645575 1516 dbSNP
rs912240191 1538 dbSNP
rs1334414774 1541 dbSNP
rs180754539 1544 dbSNP
rs987792795 1551 dbSNP
rs1345533482 1557 dbSNP
rs1415772483 1564 dbSNP
rs539840032 1567 dbSNP
rs1280713299 1572 dbSNP
rs570899810 1579 dbSNP
rs1202928645 1602 dbSNP
rs1399470814 1607 dbSNP
rs902363683 1608 dbSNP
rs1394975003 1617 dbSNP
rs1453076115 1621 dbSNP
rs1171448602 1627 dbSNP
rs1175942410 1628 dbSNP
rs1376386344 1634 dbSNP
rs1473230832 1636 dbSNP
rs1287331038 1645 dbSNP
rs1387309652 1662 dbSNP
rs1382830876 1667 dbSNP
rs1022160858 1668 dbSNP
rs1011234583 1681 dbSNP
rs1268949760 1683 dbSNP
rs1303879811 1688 dbSNP
rs1352707473 1690 dbSNP
rs1236502409 1697 dbSNP
rs139029123 1700 dbSNP
rs1262099154 1702 dbSNP
rs554154974 1705 dbSNP
rs534538140 1706 dbSNP
rs1258600103 1709 dbSNP
rs1055160000 1712 dbSNP
rs1195977923 1718 dbSNP
rs568534541 1719 dbSNP
rs1440880540 1720 dbSNP
rs906264538 1721 dbSNP
rs1047488216 1722 dbSNP
rs1001477688 1728 dbSNP
rs929082215 1732 dbSNP
rs920750466 1733 dbSNP
rs973630055 1734 dbSNP
rs943615301 1741 dbSNP
rs969571037 1745 dbSNP
rs987842223 1751 dbSNP
rs1308825213 1754 dbSNP
rs1317166073 1757 dbSNP
rs1222598374 1758 dbSNP
rs1329850063 1759 dbSNP
rs1270734653 1763 dbSNP
rs1336301984 1779 dbSNP
rs1216163395 1784 dbSNP
rs1254154711 1788 dbSNP
rs954704664 1795 dbSNP
rs1175885135 1807 dbSNP
rs1253023181 1830 dbSNP
rs1419896583 1834 dbSNP
rs1463057277 1840 dbSNP
rs924665038 1840 dbSNP
rs1023750118 1842 dbSNP
rs968826248 1850 dbSNP
rs1349672797 1878 dbSNP
rs1439871236 1878 dbSNP
rs1013694866 1879 dbSNP
rs1284527942 1893 dbSNP
rs1449824745 1896 dbSNP
rs1022547514 1907 dbSNP
rs1338311262 1927 dbSNP
rs368116916 1932 dbSNP
rs1291044415 1935 dbSNP
rs1230727773 1938 dbSNP
rs532027272 1939 dbSNP
rs1010743786 1940 dbSNP
rs1036366356 1956 dbSNP
rs1307452730 1958 dbSNP
rs112109974 1966 dbSNP
rs1004882538 1968 dbSNP
rs887057991 1972 dbSNP
rs1481155443 1974 dbSNP
rs1048293318 1975 dbSNP
rs931161433 1990 dbSNP
rs1003139640 1997 dbSNP
rs548781419 1999 dbSNP
rs577535794 2000 dbSNP
rs906190927 2003 dbSNP
rs745726157 2004 dbSNP
rs780852235 2006 dbSNP
rs528943786 2007 dbSNP
rs898958640 2008 dbSNP
rs757018556 2018 dbSNP
rs1038234898 2022 dbSNP
rs1354956189 2023 dbSNP
rs1433845761 2027 dbSNP
rs943556192 2028 dbSNP
rs77138864 2029 dbSNP
rs1415031919 2031 dbSNP
rs1183943044 2034 dbSNP
rs1206976591 2039 dbSNP
rs1359244812 2041 dbSNP
rs943796025 2052 dbSNP
rs1298340889 2055 dbSNP
rs557358689 2057 dbSNP
rs766703595 2058 dbSNP
rs912276244 2073 dbSNP
rs988254454 2074 dbSNP
rs956392338 2088 dbSNP
rs1237115974 2092 dbSNP
rs1474460927 2098 dbSNP
rs375189623 2101 dbSNP
rs74784245 2105 dbSNP
rs192004988 2106 dbSNP
rs1466319002 2108 dbSNP
rs1246212125 2132 dbSNP
rs1453686121 2142 dbSNP
rs540937973 2152 dbSNP
rs1023823393 2156 dbSNP
rs1171553944 2157 dbSNP
rs1206775808 2166 dbSNP
rs1376991409 2168 dbSNP
rs537531372 2177 dbSNP
rs1317174327 2182 dbSNP
rs968752586 2191 dbSNP
rs1290386475 2194 dbSNP
rs764051320 2204 dbSNP
rs1288901933 2212 dbSNP
rs1353897923 2215 dbSNP
rs1366585643 2222 dbSNP
rs527597363 2228 dbSNP
rs959254787 2232 dbSNP
rs1435307264 2234 dbSNP
rs1033954293 2235 dbSNP
rs1005320435 2237 dbSNP
rs1435075860 2261 dbSNP
rs887765155 2263 dbSNP
rs1218081272 2265 dbSNP
rs187607858 2266 dbSNP
rs1467977836 2267 dbSNP
rs1191660358 2273 dbSNP
rs1396733882 2274 dbSNP
rs1454529700 2278 dbSNP
rs373662085 2280 dbSNP
rs1167434594 2282 dbSNP
rs1405375630 2293 dbSNP
rs1403960988 2294 dbSNP
rs1413452246 2299 dbSNP
rs1159203348 2303 dbSNP
rs1393023307 2307 dbSNP
rs1440894874 2312 dbSNP
rs1324466053 2318 dbSNP
rs993126026 2319 dbSNP
rs1169489734 2322 dbSNP
rs765422038 2323 dbSNP
rs542010847 2336 dbSNP
rs1225609010 2338 dbSNP
rs1039516600 2341 dbSNP
rs1280558669 2362 dbSNP
rs943873574 2364 dbSNP
rs1187976369 2367 dbSNP
rs1485534920 2372 dbSNP
rs1254795367 2374 dbSNP
rs576350924 2383 dbSNP
rs1180863608 2386 dbSNP
rs1223585814 2390 dbSNP
rs889270587 2394 dbSNP
rs1051960563 2398 dbSNP
rs1449680819 2401 dbSNP
rs1052178903 2402 dbSNP
rs758450013 2405 dbSNP
rs1159427884 2406 dbSNP
rs1416615000 2407 dbSNP
rs1459385178 2413 dbSNP
rs933560052 2417 dbSNP
rs1397348770 2428 dbSNP
rs1406416900 2432 dbSNP
rs116972786 2435 dbSNP
rs1041707519 2442 dbSNP
rs1289190624 2443 dbSNP
rs3173027 2447 dbSNP
rs1343832900 2453 dbSNP
rs914617827 2461 dbSNP
rs765613060 2462 dbSNP
rs1195098762 2464 dbSNP
rs577289869 2465 dbSNP
rs916830838 2469 dbSNP
rs1439337978 2472 dbSNP
rs1182500591 2473 dbSNP
rs759834903 2476 dbSNP
rs926469272 2479 dbSNP
rs992360088 2483 dbSNP
rs960851640 2484 dbSNP
rs1015446673 2488 dbSNP
rs750923167 2489 dbSNP
rs1026196014 2493 dbSNP
rs1343329240 2505 dbSNP
rs971674907 2508 dbSNP
rs1394838895 2514 dbSNP
rs1431996648 2524 dbSNP
rs374484002 2527 dbSNP
rs983571438 2529 dbSNP
rs1016365011 2530 dbSNP
rs952195800 2532 dbSNP
rs1007294019 2533 dbSNP
rs1434878582 2536 dbSNP
rs765663357 2543 dbSNP
rs776930155 2547 dbSNP
rs996092547 2550 dbSNP
rs1205634917 2552 dbSNP
rs1349694455 2553 dbSNP
rs1279289402 2562 dbSNP
rs73787062 2570 dbSNP
rs1212498559 2572 dbSNP
rs555139157 2581 dbSNP
rs903408898 2582 dbSNP
rs1018141212 2583 dbSNP
rs1193162300 2590 dbSNP
rs1168109351 2598 dbSNP
rs1433843876 2599 dbSNP
rs534193984 2600 dbSNP
rs1427300824 2606 dbSNP
rs1394798006 2607 dbSNP
rs1042012046 2612 dbSNP
rs947652052 2616 dbSNP
rs893124562 2617 dbSNP
rs766671160 2635 dbSNP
rs111526398 2643 dbSNP
rs1267981634 2645 dbSNP
rs1228963208 2647 dbSNP
rs773627236 2651 dbSNP
rs575090409 2657 dbSNP
rs1272049091 2658 dbSNP
rs181999625 2660 dbSNP
rs1485314804 2667 dbSNP
rs538037351 2688 dbSNP
rs935110213 2692 dbSNP
rs1189762558 2693 dbSNP
rs1252837678 2700 dbSNP
rs981874939 2706 dbSNP
rs949234172 2713 dbSNP
rs903566687 2716 dbSNP
rs1043437944 2721 dbSNP
rs971935134 2722 dbSNP
rs963651620 2728 dbSNP
rs1156898053 2730 dbSNP
rs1015920921 2731 dbSNP
rs769226734 2732 dbSNP
rs947692474 2735 dbSNP
rs1435791977 2736 dbSNP
rs1289429625 2741 dbSNP
rs745533977 2746 dbSNP
rs766452419 2749 dbSNP
rs112387670 2750 dbSNP
rs1307667121 2761 dbSNP
rs997662608 2763 dbSNP
rs903335265 2764 dbSNP
rs776522290 2767 dbSNP
rs1209947956 2769 dbSNP
rs1252895028 2771 dbSNP
rs939558732 2774 dbSNP
rs1011824319 2786 dbSNP
rs1174020738 2787 dbSNP
rs1193315329 2790 dbSNP
rs1412749331 2791 dbSNP
rs1428513058 2794 dbSNP
rs1179907946 2796 dbSNP
rs908046543 2798 dbSNP
rs983990860 2805 dbSNP
rs1457803363 2812 dbSNP
rs772452103 2816 dbSNP
rs1473459115 2818 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuuggagccgaccCCGCCCGa 5'
                        ||||||| 
Target 5' --------------GGCGGGCc 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001098813 | 3UTR | ACAGACUCCAGUGUUUACAGCCUUGCUUUCCUCCCACCGACCCUGGCCCCAGGCUGCCCCGGGCCUGGCGGGCCACCCCUCUCUAUGCAAACACGUAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000378706.1 | 3UTR | GGCGGGCCACCCCUCUCUAUGCAAACACG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-4707-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT442514 SYT7 synaptotagmin 7 2 4
MIRT457799 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT466318 THRA thyroid hormone receptor, alpha 2 2
MIRT486129 TRAF3 TNF receptor associated factor 3 2 2
MIRT492341 SEPT8 septin 8 2 2
MIRT495690 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT496928 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT499518 MAFK MAF bZIP transcription factor K 2 2
MIRT501367 REXO1 RNA exonuclease 1 homolog 2 4
MIRT501636 PIAS4 protein inhibitor of activated STAT 4 2 4
MIRT521071 SLC25A16 solute carrier family 25 member 16 2 2
MIRT525700 PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2 2
MIRT532722 DDTL D-dopachrome tautomerase like 2 2
MIRT533137 WWC1 WW and C2 domain containing 1 2 4
MIRT537288 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT570555 PHF21B PHD finger protein 21B 2 2
MIRT573469 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576750 Tmem127 transmembrane protein 127 2 2
MIRT609342 DAAM2 dishevelled associated activator of morphogenesis 2 2 2
MIRT610638 PIGM phosphatidylinositol glycan anchor biosynthesis class M 2 2
MIRT612591 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT614237 WDR53 WD repeat domain 53 2 4
MIRT622784 PGK1 phosphoglycerate kinase 1 2 2
MIRT628880 MED16 mediator complex subunit 16 2 2
MIRT629550 SPN sialophorin 2 2
MIRT634714 DDX19B DEAD-box helicase 19B 2 2
MIRT634932 GTF2H2C GTF2H2 family member C 2 4
MIRT635341 RBL1 RB transcriptional corepressor like 1 2 2
MIRT637838 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT644311 NFKBID NFKB inhibitor delta 2 2
MIRT649206 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT657262 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT658919 DPY19L4 dpy-19 like 4 2 2
MIRT663608 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT667425 MFAP2 microfibril associated protein 2 2 2
MIRT667667 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT668144 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT668540 ERGIC1 endoplasmic reticulum-golgi intermediate compartment 1 2 2
MIRT670039 NFRKB nuclear factor related to kappaB binding protein 2 2
MIRT670875 RAB10 RAB10, member RAS oncogene family 2 2
MIRT672694 ZNF677 zinc finger protein 677 2 2
MIRT673107 MFSD2A major facilitator superfamily domain containing 2A 2 2
MIRT673508 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674244 NUP62 nucleoporin 62 2 4
MIRT676541 IRGQ immunity related GTPase Q 2 2
MIRT676787 CXorf38 chromosome X open reading frame 38 2 4
MIRT677600 PRKX protein kinase, X-linked 2 2
MIRT678607 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT678940 MYADM myeloid associated differentiation marker 2 2
MIRT679104 CD99 CD99 molecule (Xg blood group) 2 2
MIRT679196 WNT2B Wnt family member 2B 2 2
MIRT679325 ZMYM4 zinc finger MYM-type containing 4 2 2
MIRT679634 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT679819 TMEM106B transmembrane protein 106B 2 2
MIRT679898 FBXO48 F-box protein 48 2 2
MIRT680579 ZNF784 zinc finger protein 784 2 2
MIRT680600 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT682991 RNF40 ring finger protein 40 2 4
MIRT683483 ZNF7 zinc finger protein 7 2 2
MIRT683681 MICA MHC class I polypeptide-related sequence A 2 2
MIRT684122 CEP104 centrosomal protein 104 2 2
MIRT684774 MYO1F myosin IF 2 2
MIRT685698 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT686471 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT687940 HMGB1 high mobility group box 1 2 2
MIRT688627 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT689110 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT690063 MBD1 methyl-CpG binding domain protein 1 2 2
MIRT691067 NUGGC nuclear GTPase, germinal center associated 2 2
MIRT691317 KIAA1841 KIAA1841 2 2
MIRT692778 SYNPO2L synaptopodin 2 like 2 2
MIRT694087 KIAA0930 KIAA0930 2 2
MIRT696148 WDR59 WD repeat domain 59 2 2
MIRT696176 GNB5 G protein subunit beta 5 2 2
MIRT696434 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT697974 TSPAN6 tetraspanin 6 2 2
MIRT698917 SPEM1 spermatid maturation 1 2 2
MIRT699312 SLC35F5 solute carrier family 35 member F5 2 4
MIRT700500 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 2
MIRT700557 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT701817 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT702045 METTL21A methyltransferase like 21A 2 2
MIRT702215 LPCAT1 lysophosphatidylcholine acyltransferase 1 2 2
MIRT702337 KLHL7 kelch like family member 7 2 2
MIRT704139 DNAL1 dynein axonemal light chain 1 2 2
MIRT704189 LDHD lactate dehydrogenase D 2 2
MIRT705344 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT706097 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT709068 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT717579 VTA1 vesicle trafficking 1 2 2
MIRT722440 ZBTB7B zinc finger and BTB domain containing 7B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4707 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4707 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4707 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4707 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4707-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4707-3p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4707-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4707-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-4707-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4707-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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