pre-miRNA Information
pre-miRNA hsa-mir-3160-1   
Genomic Coordinates chr11: 46451805 - 46451889
Description Homo sapiens miR-3160-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3160-2   
Genomic Coordinates chr11: 46451807 - 46451887
Description Homo sapiens miR-3160-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3160-3p
Sequence 54| AGAGCUGAGACUAGAAAGCCCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30582333 1 COSMIC
COSN1535547 3 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1396368683 1 dbSNP
rs1162409303 2 dbSNP
rs1404378453 12 dbSNP
rs1171960732 14 dbSNP
rs1324633375 16 dbSNP
rs1187765019 16 dbSNP
rs1300058326 19 dbSNP
rs1432898407 21 dbSNP
rs1011279103 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PLEC   
Synonyms EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN
Description plectin
Transcript NM_000445   
Other Transcripts NM_201378 , NM_201379 , NM_201380 , NM_201381 , NM_201382 , NM_201383 , NM_201384   
Expression
Putative miRNA Targets on PLEC
3'UTR of PLEC
(miRNA target sites are highlighted)
>PLEC|NM_000445|3'UTR
   1 GGCTGCCTGCGCCCACCCCGCTCTGCATGCGGCCCAGCCCGGCTCCCACCGAGGCGCGGGGGCCGTTTTCAACGCTTAAA
  81 GGTGTCTTCCTCCCAAGTGGTGCCTAAAGTTTAACCAAAAAGACCAGACTAATATATTAATATATATCTGCTGTCCAGAC
 161 AGCCTGTATCTTGGGGGACAGGGCTGGCCCAGCCCTGCTGGCCGCCTCACCCCCTCGGGTCTCCTCACTCCCTTCTACCT
 241 GCCACTCACACAGCCAGGTGCCTTGGAGGGTCCCAAGCTGGGCCCCAGCCCACCCTCCTGTCTTCCCAGGGTAGCCCGCC
 321 TGCCAGTCCTAGCTGCACAGGGCAGCTGGGCCCAACCCTGTCTGTAGAGGGCCCTGGTGTTTCTAGCACTGGCCTGCACG
 401 GTGGGCCTTGCTGGGGACGGGGGGCCCCAGTCAGCCTCTCTCCCAGTCTACCCAGAGAAGCCCCTTCCCCATGGGAAGAC
 481 GAGGCCCTCGGGCCCAGCCCCCACAGTGCTGTCTGATCTGTGCTTTCCAGCTCACCCCCCACACTCACTCCTGAGACCCC
 561 TGGCCTCCGGCGTCAGCCTCCAGCCTCTGTTCCCCTAGTAAGTGCCTTCCATGTCGGCCTCTAACCCCAGGCCCCGAGGA
 641 CCCAGACCCAGTGGGGAGGCGGACGTTCCAGCCGGCATGGCTGGGAACTGCAGACCTGTCCTCCTGGTGGGTCCAGGGGC
 721 CCCTCCAGCTTGTGGAGCCCCACACTGGGGTGCCGCCTGCCCGTCTCTCTCCCATGGAGCCCCAGCCCCCTTTGGGCCCA
 801 GGGACACCAGCCAGGCTCTGTGCTGACCCTCCTGTTGCACCCAGCCCTGGTCTCAGCAGCGACCACCCCTGCCTCCACCC
 881 TCTGAGCTTTGCATGTTCCACTAACCCCGGGCGGGTGGCAGGTGGAGGTGTCAGGCTGCTGGCGCCTCTGCAAGGGCAGA
 961 ACACTAACCTGACCGTGGGCGGGGCCTTGCGGTATCCGCCCCCAATAAAAGCAATTCCAACCTTCCCGTGAAAAAAAAAA
1041 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acccgaaaGAUCAGAGUCGaga 5'
                  ||:||||||||   
Target 5' acccagccCTGGTCTCAGCagc 3'
839 - 860 126.00 -16.60
2
miRNA  3' accCGAAAGAUCAGAGUCGAGa 5'
             ||||||      |||||| 
Target 5' tgtGCTTTC------CAGCTCa 3'
519 - 534 126.00 -11.70
3
miRNA  3' acCCGAAAGAUCAGAGUC-GAGa 5'
            |||  || :|  |||| ||| 
Target 5' ctGGC-CTCCGGCGTCAGCCTCc 3'
560 - 581 119.00 -11.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
93012 10 ClinVar
93013 19 ClinVar
COSN28697285 10 COSMIC
COSN17223169 30 COSMIC
COSN26585849 57 COSMIC
COSN31482912 216 COSMIC
COSN28726832 237 COSMIC
COSN20801370 342 COSMIC
COSN31591328 578 COSMIC
COSN30543985 765 COSMIC
COSN28662451 883 COSMIC
COSN16445075 960 COSMIC
COSN5677332 970 COSMIC
COSN19492712 979 COSMIC
COSN31556046 981 COSMIC
COSN31517916 1008 COSMIC
rs1065837 10 GWAS
rs117961539 879 GWAS
rs7155 883 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1174849475 3 dbSNP
rs1019588892 7 dbSNP
rs1065837 10 dbSNP
rs1173250738 11 dbSNP
rs782644731 17 dbSNP
rs890358346 18 dbSNP
rs11997227 19 dbSNP
rs998642427 20 dbSNP
rs1304131744 24 dbSNP
rs1372867774 25 dbSNP
rs781835109 30 dbSNP
rs1255036846 31 dbSNP
rs1339588564 37 dbSNP
rs1270221711 40 dbSNP
rs1436742796 41 dbSNP
rs1043287163 47 dbSNP
rs571241058 48 dbSNP
rs948456427 49 dbSNP
rs555807556 50 dbSNP
rs1056788299 51 dbSNP
rs537472680 55 dbSNP
rs566877959 56 dbSNP
rs1166396161 57 dbSNP
rs1395836481 58 dbSNP
rs1462067970 63 dbSNP
rs1326491518 64 dbSNP
rs1396673230 65 dbSNP
rs1438640582 72 dbSNP
rs368999675 73 dbSNP
rs1326832497 74 dbSNP
rs1229094252 77 dbSNP
rs1268093275 82 dbSNP
rs1316746524 86 dbSNP
rs931562484 88 dbSNP
rs747942292 90 dbSNP
rs1467476348 92 dbSNP
rs1209802672 103 dbSNP
rs1262811169 108 dbSNP
rs920067331 116 dbSNP
rs1191261575 117 dbSNP
rs1372789798 122 dbSNP
rs1475568936 122 dbSNP
rs1167121513 129 dbSNP
rs527585837 133 dbSNP
rs1459769562 135 dbSNP
rs371121842 136 dbSNP
rs1020146101 138 dbSNP
rs1385369572 140 dbSNP
rs986744036 144 dbSNP
rs1315773900 146 dbSNP
rs1339386349 147 dbSNP
rs956744202 148 dbSNP
rs1294551723 149 dbSNP
rs781910589 151 dbSNP
rs76773857 153 dbSNP
rs782792810 156 dbSNP
rs1021433083 159 dbSNP
rs111529162 160 dbSNP
rs1203813977 162 dbSNP
rs782443600 163 dbSNP
rs1486082571 165 dbSNP
rs533113908 169 dbSNP
rs894209227 170 dbSNP
rs1057325226 173 dbSNP
rs1474948089 174 dbSNP
rs1163990788 175 dbSNP
rs1364372725 186 dbSNP
rs1455299414 189 dbSNP
rs562991988 193 dbSNP
rs1359700339 197 dbSNP
rs186103577 203 dbSNP
rs1314383932 204 dbSNP
rs1352989797 209 dbSNP
rs868937678 211 dbSNP
rs1308319213 212 dbSNP
rs1319191847 213 dbSNP
rs886742360 214 dbSNP
rs1285701720 216 dbSNP
rs1046768065 218 dbSNP
rs1349069384 224 dbSNP
rs931529558 232 dbSNP
rs920185511 242 dbSNP
rs1482961088 244 dbSNP
rs1177799445 251 dbSNP
rs1252766670 252 dbSNP
rs1420767083 253 dbSNP
rs975595754 254 dbSNP
rs529314500 255 dbSNP
rs1379429977 259 dbSNP
rs942886062 261 dbSNP
rs1435148652 269 dbSNP
rs1175124548 275 dbSNP
rs562054751 282 dbSNP
rs1373298663 283 dbSNP
rs182393209 286 dbSNP
rs1298183504 295 dbSNP
rs986880911 300 dbSNP
rs956794396 305 dbSNP
rs1030918558 306 dbSNP
rs1309230617 310 dbSNP
rs34818236 312 dbSNP
rs372203837 312 dbSNP
rs1237044221 314 dbSNP
rs573437070 317 dbSNP
rs1205534731 318 dbSNP
rs1253103903 320 dbSNP
rs979419155 321 dbSNP
rs968634232 338 dbSNP
rs190996425 341 dbSNP
rs1454538236 342 dbSNP
rs1195201036 343 dbSNP
rs546097543 346 dbSNP
rs894335994 356 dbSNP
rs1170730982 359 dbSNP
rs1035533152 360 dbSNP
rs782127167 366 dbSNP
rs781980059 374 dbSNP
rs1460059563 376 dbSNP
rs1331251691 380 dbSNP
rs1395786108 383 dbSNP
rs1046736950 393 dbSNP
rs1301657065 398 dbSNP
rs782811387 399 dbSNP
rs782142401 400 dbSNP
rs1305834983 401 dbSNP
rs1218159240 404 dbSNP
rs575767264 405 dbSNP
rs1468806923 418 dbSNP
rs186528416 419 dbSNP
rs1488061115 425 dbSNP
rs116530379 427 dbSNP
rs573345975 440 dbSNP
rs1476546018 443 dbSNP
rs1169263358 450 dbSNP
rs140366494 453 dbSNP
rs935392471 454 dbSNP
rs11555242 455 dbSNP
rs924040104 460 dbSNP
rs1290843678 464 dbSNP
rs550679214 468 dbSNP
rs979386633 471 dbSNP
rs1360057953 477 dbSNP
rs1218250904 479 dbSNP
rs1293942850 480 dbSNP
rs147146123 481 dbSNP
rs1235033255 487 dbSNP
rs1287688052 489 dbSNP
rs1320881969 490 dbSNP
rs1216303694 492 dbSNP
rs1243640341 498 dbSNP
rs1487082808 501 dbSNP
rs1192515576 503 dbSNP
rs1257582686 507 dbSNP
rs914488142 508 dbSNP
rs991784090 511 dbSNP
rs1413779455 515 dbSNP
rs1401812469 519 dbSNP
rs1161649391 528 dbSNP
rs1399579839 538 dbSNP
rs958654770 540 dbSNP
rs1445992292 542 dbSNP
rs566667242 544 dbSNP
rs1378274881 548 dbSNP
rs782231129 552 dbSNP
rs1286032723 553 dbSNP
rs1035499993 558 dbSNP
rs1215402305 561 dbSNP
rs1280684382 564 dbSNP
rs1184710336 565 dbSNP
rs143370516 568 dbSNP
rs1470774965 569 dbSNP
rs530662366 571 dbSNP
rs539259627 572 dbSNP
rs1377560902 578 dbSNP
rs1412992307 582 dbSNP
rs1333546848 589 dbSNP
rs1336456068 595 dbSNP
rs1442813667 598 dbSNP
rs1311427925 615 dbSNP
rs868930632 616 dbSNP
rs781959804 618 dbSNP
rs1025423928 620 dbSNP
rs995179733 625 dbSNP
rs898187901 626 dbSNP
rs1039379154 631 dbSNP
rs569032539 632 dbSNP
rs1277232201 633 dbSNP
rs1007514962 635 dbSNP
rs891393569 636 dbSNP
rs1236954099 638 dbSNP
rs1439456839 641 dbSNP
rs1051175506 648 dbSNP
rs935528348 652 dbSNP
rs1397274870 654 dbSNP
rs1477136308 655 dbSNP
rs1172263975 658 dbSNP
rs1397264539 660 dbSNP
rs551135875 661 dbSNP
rs375622785 664 dbSNP
rs924027128 665 dbSNP
rs1043825489 674 dbSNP
rs1445964784 681 dbSNP
rs946832424 691 dbSNP
rs916531899 701 dbSNP
rs1230580334 707 dbSNP
rs990854876 715 dbSNP
rs958843876 717 dbSNP
rs1339473099 723 dbSNP
rs1219998976 724 dbSNP
rs1255621229 725 dbSNP
rs1457658321 740 dbSNP
rs928566646 744 dbSNP
rs1255261904 752 dbSNP
rs114463673 754 dbSNP
rs1198418333 761 dbSNP
rs951232436 762 dbSNP
rs546663217 763 dbSNP
rs1138359 767 dbSNP
rs1168545259 774 dbSNP
rs1464990118 785 dbSNP
rs1326548582 787 dbSNP
rs528453800 789 dbSNP
rs1384925466 794 dbSNP
rs962494185 797 dbSNP
rs1326592240 799 dbSNP
rs1401467090 815 dbSNP
rs571369229 820 dbSNP
rs1316812745 823 dbSNP
rs1234405944 827 dbSNP
rs782301089 835 dbSNP
rs1267824379 837 dbSNP
rs1006569461 842 dbSNP
rs1209560333 845 dbSNP
rs1262876360 848 dbSNP
rs1489372330 850 dbSNP
rs11555243 852 dbSNP
rs891363560 855 dbSNP
rs1262534997 860 dbSNP
rs1475597718 861 dbSNP
rs1165552236 866 dbSNP
rs879971964 868 dbSNP
rs1029891882 870 dbSNP
rs181184603 876 dbSNP
rs1456341641 877 dbSNP
rs1162361790 878 dbSNP
rs117961539 879 dbSNP
rs1296005679 881 dbSNP
rs1339269640 882 dbSNP
rs7155 883 dbSNP
rs1314270387 884 dbSNP
rs1339160085 886 dbSNP
rs189205952 893 dbSNP
rs1261634156 894 dbSNP
rs1356349949 900 dbSNP
rs1214683393 901 dbSNP
rs1285655819 905 dbSNP
rs1486030106 906 dbSNP
rs1183615893 908 dbSNP
rs779305761 909 dbSNP
rs1421943788 911 dbSNP
rs1186775613 912 dbSNP
rs1364130404 913 dbSNP
rs185955457 924 dbSNP
rs1156445990 927 dbSNP
rs543927812 928 dbSNP
rs939391648 930 dbSNP
rs1434957344 935 dbSNP
rs782619390 939 dbSNP
rs377027885 943 dbSNP
rs1379563156 944 dbSNP
rs1395931764 944 dbSNP
rs929885255 946 dbSNP
rs1238496668 948 dbSNP
rs1309004625 949 dbSNP
rs1348786477 950 dbSNP
rs918383825 952 dbSNP
rs138209950 955 dbSNP
rs1482991120 956 dbSNP
rs1199801165 963 dbSNP
rs868978901 967 dbSNP
rs1238780197 972 dbSNP
rs1441481804 973 dbSNP
rs1176479015 974 dbSNP
rs72693391 975 dbSNP
rs1433362868 979 dbSNP
rs1177857226 980 dbSNP
rs555009100 981 dbSNP
rs1299226361 983 dbSNP
rs1403008874 985 dbSNP
rs1445218632 987 dbSNP
rs1331051150 990 dbSNP
rs533573372 990 dbSNP
rs1221132768 991 dbSNP
rs1299550852 993 dbSNP
rs1228172067 997 dbSNP
rs955076893 998 dbSNP
rs1459006169 1001 dbSNP
rs1196701287 1005 dbSNP
rs572749914 1014 dbSNP
rs1192563893 1015 dbSNP
rs1422688327 1016 dbSNP
rs1432245537 1017 dbSNP
rs34965315 1025 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acccgaaagaucagaGUCGAGa 5'
                         |||||| 
Target 5' -----------uuucCAGCUCa 3'
1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acccGAAAGAUCAGAGUCGAGa 5'
              |||||      |||||| 
Target 5' ----CUUUC------CAGCUCa 3'
1 - 12
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_201384 | 3UTR | ACCCAGAGAAGCCCCUUCCCCAUGGGAAGACGAGGCCCUCGGGCCCAGCCCCCACAGUGCUGUCUGAUCUGUGCUUUCCAGCUCACCCCCCACACUCACUCCUGAGACCCCUGGCCUCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000345136.3 | 3UTR | UUUCCAGCUCACCCCCCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
118 hsa-miR-3160-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066658 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT075318 SF3B3 splicing factor 3b subunit 3 2 4
MIRT077083 EIF1 eukaryotic translation initiation factor 1 2 2
MIRT100381 HSPA1B heat shock protein family A (Hsp70) member 1B 2 6
MIRT135259 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT184913 ZNF268 zinc finger protein 268 2 2
MIRT218862 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT446580 FPR2 formyl peptide receptor 2 2 2
MIRT448834 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT449455 RNF13 ring finger protein 13 2 2
MIRT452284 CARD8 caspase recruitment domain family member 8 2 2
MIRT452628 FAM162A family with sequence similarity 162 member A 2 2
MIRT453454 GLG1 golgi glycoprotein 1 2 2
MIRT454188 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 6
MIRT454434 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT454575 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT455555 TRAF1 TNF receptor associated factor 1 2 6
MIRT455841 MPL MPL proto-oncogene, thrombopoietin receptor 2 6
MIRT455969 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT456805 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457320 DUSP19 dual specificity phosphatase 19 2 2
MIRT457366 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457684 ZNF587 zinc finger protein 587 2 2
MIRT458158 LYRM4 LYR motif containing 4 2 6
MIRT458641 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT459134 FADS6 fatty acid desaturase 6 2 2
MIRT459153 NARF nuclear prelamin A recognition factor 2 4
MIRT460460 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460974 STK17B serine/threonine kinase 17b 2 2
MIRT461439 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT461507 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2 2
MIRT462490 GSR glutathione-disulfide reductase 2 2
MIRT462638 PHF5A PHD finger protein 5A 2 2
MIRT463279 ZFX zinc finger protein, X-linked 2 2
MIRT463360 ZFAND4 zinc finger AN1-type containing 4 2 2
MIRT465777 TMOD3 tropomodulin 3 2 2
MIRT466143 TMEM120B transmembrane protein 120B 2 2
MIRT468401 SETD3 SET domain containing 3 2 2
MIRT468998 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT471574 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT472108 NME2 NME/NM23 nucleoside diphosphate kinase 2 2 2
MIRT472125 NME1-NME2 NME1-NME2 readthrough 2 2
MIRT473020 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT473083 MORN4 MORN repeat containing 4 2 2
MIRT475598 HMGB2 high mobility group box 2 2 4
MIRT475937 GXYLT2 glucoside xylosyltransferase 2 2 8
MIRT476117 GPR157 G protein-coupled receptor 157 2 2
MIRT476406 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT478003 DNAL1 dynein axonemal light chain 1 2 2
MIRT487969 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489418 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491522 IL10RA interleukin 10 receptor subunit alpha 2 2
MIRT492673 PLEC plectin 2 2
MIRT493545 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT513085 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT514009 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT516683 ZNF860 zinc finger protein 860 2 2
MIRT518392 ZNF250 zinc finger protein 250 2 2
MIRT522683 LUZP1 leucine zipper protein 1 2 6
MIRT524488 CEP97 centrosomal protein 97 2 2
MIRT527457 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT527705 IL17REL interleukin 17 receptor E like 2 2
MIRT531647 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT532381 UMPS uridine monophosphate synthetase 2 2
MIRT532588 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT533555 TPM4 tropomyosin 4 2 2
MIRT548371 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT550250 PVR poliovirus receptor 2 2
MIRT552555 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554113 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT554131 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT561344 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT561638 RUNX3 runt related transcription factor 3 2 2
MIRT566497 PBX2P1 PBX homeobox 2 pseudogene 1 2 2
MIRT570583 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572731 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT574041 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT575231 Fut1 fucosyltransferase 1 2 2
MIRT606811 BICD2 BICD cargo adaptor 2 2 2
MIRT621016 CLSTN3 calsyntenin 3 2 2
MIRT637852 PDCL3 phosducin like 3 2 2
MIRT640477 ZNF557 zinc finger protein 557 2 2
MIRT642827 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT643887 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT664874 PCNXL2 pecanex homolog 2 2 2
MIRT680528 PRIM2 DNA primase subunit 2 2 2
MIRT680648 KIAA1456 KIAA1456 2 2
MIRT680807 ZNF578 zinc finger protein 578 2 2
MIRT680921 STX2 syntaxin 2 2 2
MIRT681112 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT681147 INTS7 integrator complex subunit 7 2 2
MIRT681966 TFCP2 transcription factor CP2 2 2
MIRT684316 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT684906 GSG2 histone H3 associated protein kinase 2 2
MIRT685499 MED16 mediator complex subunit 16 2 2
MIRT685929 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686875 SLC25A32 solute carrier family 25 member 32 2 2
MIRT688204 FNIP1 folliculin interacting protein 1 2 2
MIRT688791 CCNB1 cyclin B1 2 2
MIRT689227 RPS19 ribosomal protein S19 2 2
MIRT690470 ZNF33A zinc finger protein 33A 2 2
MIRT691982 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT694006 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT694529 TRIM72 tripartite motif containing 72 2 2
MIRT695420 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT695784 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT697799 UBXN2A UBX domain protein 2A 2 2
MIRT698275 TMEM2 transmembrane protein 2 2 2
MIRT698317 TMEM136 transmembrane protein 136 2 2
MIRT699971 RREB1 ras responsive element binding protein 1 2 2
MIRT700717 PNO1 partner of NOB1 homolog 2 2
MIRT701721 MTMR12 myotubularin related protein 12 2 2
MIRT701879 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT702959 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT706178 ZNF716 zinc finger protein 716 2 2
MIRT706463 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT718154 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT718711 ANKRD18A ankyrin repeat domain 18A 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3160-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3160-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-3160-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3160-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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