miRTarBase - #MIRT493265


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pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MDFIC   
Synonyms HIC, MDFIC1
Description MyoD family inhibitor domain containing
Transcript NM_001166345   
Other Transcripts NM_001166346 , NM_199072   
Expression
Putative miRNA Targets on MDFIC
3'UTR of MDFIC
(miRNA target sites are highlighted)		 
>MDFIC|NM_001166345|3'UTR
   1 ATATTTATCTTTTGTTTGTGTTAAAACTGGAGAGTGTTTAAAAATTTCCTTTTGGGGGGAAGAAAAGCACATTGTAAGAT
  81 TCTCATGAAACAACATGGAATTTGCACTGTTAACTCATTATTGTAAGTAATCTCTGAAAGCCTTTTTACTTTAACCAAAT
 161 CTACATGGTTTAATATGTGAAATTTTAACTACTTTAACTAGTTTTATAAATTTCTTAATATGTTACAATAACTTAGGGAC
 241 ATTTTGACACCCCCCTTCCCAAATGTTAAATGCCTTCTCCTTTTTACCGATATTTCTGTTTCTTTTAACCGTTCTCAGGA
 321 GCACTTTGCTCCAAATATATTATTTTTCAGTGTGTATTTAAACGAGGCAGTTTATTTTGATATGTATCTATTCATGATTG
 401 AAAGGAAGCAGTCTTGGCCAGGCACGGTGGCTTACACCTGTAACCCTGGCATTTTGGGAGGCCAAGGTGGGCAGATTGCC
 481 TGAGCTCAGGAGTTCGAGACCAGCCAGGGCAACATGGTGAAACCCCATCTCTACTAAAATACAAAAAGTTAGCTGGGCTT
 561 GGCGGTGTGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGAGAGGCGGAAGTTGCAG
 641 TGAGCCGAGATTGTGCCACTGAACTCCAACCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCTAAATAAATAA
 721 ATAAATAAATAAATAAATAAATAAATAAATAAACAAACCAGTCTTTATTTTAAAAGAAACTTTAGGAAACAAACCCACAT
 801 AATAGTTGGGAACCAGTGTTGATCTCTCTCCCTTACCTTCTCCACTTGTTCAACAGACTCTGAATGCCGACTGTGTGGAC
 881 TCTCTTCCTCAGACTGTGGGGACAGATACAATTCCACTCCTGTCCACAGGAACATGAGATTTAGCAGACTAAGGAGATCT
 961 GTAAAGAATGAACCATACCACAAGGCATACTGAAGTGAGGATTATAAGAGAAATAAACTCAAAATGCTGTTGGAATATGC
1041 AGAGAATTGCTACCAGAATATTCAGTAAGGTTTCAGGGAGAATGTGGCATTTGAGGACTCTCTTAGAATGAGTGATTCAC
1121 CTGCTATTTAAATGAATTATTTAGATTTTTGACAAAGATTTAGGTGGACACCCTAAACTGTGTGTGCCTTTAACCAGTTA
1201 AAAGAACAGTGCCTTCAGCATACTTTTTTATTAGTTGTAGGAATACAGCTTTTTGAAAAAGCTATAAAGTTTAAATTAAC
1281 TAAAAATATGCATTTTCTTACACATAATTTAAATGTTATCATACTTTTTTGATGAAAACATAATGCCTTAGTAAAATAGC
1361 TCTATTTAATAAAGAAGATTGAGTACTCTGACACATTTCATTTAAATTAGGAAATTTTTAATATTAAAATCCCAGTGTTC
1441 TGAGTTATTGAAAGGCTTTCTTTTATTTTGAGAGCTTTAGGTCTTTTTGGGATGAGAACATTTTAGTTGTTTAGTTTGTT
1521 TCTTAAGCAGTGCTATTTTTTGTAAACACAGATAAATGGAAACCATTCTTTTCAATGCAGAAGAAATCTAGATATCCCCT
1601 ACTGTGACCAAATTTCTGTATTACGATTTTATGTTAAATTAAACTAATATGGCAGGTTATAATGATCCTTAAGTGTAAAG
1681 AAATCAGTCAATTACAAGAGTAATTGTATAGTTATTGAGACCTATAGTGTGTGGCTTAGATGAAAGGGAGAGTAAATTTT
1761 CATACCATGCTCTCTCCTACTCAGTTTGATCTCTCTAAAATTGTAGTTTGGTTTGATTTAATATAATTCTTAGTAGAAAT
1841 TTTGAAAGTATGCTTTGGGATTAATAATTATTTTTAATTTTTCTGGCTGAATATCAAATTGATAGTAACAACAGAAGCAT
1921 AATTTTAGGAAGGCTTTCGCAAACCTAGCCTTTTAAGAGAGGTTTTTAACCTGAAGCATGAGAATATATCACCTGTGGTT
2001 TTTCCTTTGAGATGAAACGTAGTTTCTAGTTATATCATTACTTAAAGGGCTTAAAAAGAAAAAACTTAGCAAACTTTTGA
2081 ATCTTTCTTTTATTGCTATTTACACATACATACACACATACAAAACCTTTAAATTTTGGGATCTGAATATAATTCTGGTA
2161 AACAGCTGTCTTCATTTTTCTCCTCTAAAGAACTTAATTCATTTGTTACATAAAATATAAGGAAATCTTTATACTATTTT
2241 ACAGTAACCACAATCTAAATATTTACATATACCCAAAATTAACTTATGCTCATATATTAGGATGTGAGAATATCATCTGT
2321 TTATGGACACATGAAACCTCCTAATGACCTGGAATTGTTAGAATATTTGACTTTTTATATGCAAAGTTTTTCAACCAAGT
2401 GGTTTGTCTAATATTTAAACATGTACTGGCACAATTTGTGATGAAAATATTAGCACATTTGCAATAATGTTTCTCCATAA
2481 CAGAGAATGTTAATGGATACCAGAATTTTATTTTTGTATTTATGTTCATAGTACTTTTCCTCTTGTCTACTCCAGACAGT
2561 TATTCCATAAAGCATTTGTATAATTAAAAGGAAAACAGAAAAAGGAAAAGTAGGCAAATGTGAAAATAGTTTCAATATAT
2641 CTTATGATTTCTTAATGTAAAATGTTTTGTTGAAGTATATGGCTATCATGACTAAGTGCTAGAATTTATAGTTACAGGCG
2721 GTGTCCTTTTAAATGTGGAAAGGCTTTTAAAATATTTTAAAACTGGACCTGTATTATCCTGAATACACTATTTTGAAAAT
2801 TTTTAAAAATGACTTCTTTATTTTGCTTTACCGTATGTTTATATCTAATTGACATATTGACTAATGTTTGAAAGAATTCA
2881 ACCATAAGTTAAAATCTGAAGGTTATCTTTATCATGTTTCATCCCTGTCTGAAGATTTCCTAGTCTTCTTATGTAAATCA
2961 CATGACTCATGTCCGTAAATGAACTATGAAAGATATCGATCAGTTTATGATCATTGACATGTGATTTCAAAACACAGTGT
3041 TCTTTTAAAAATCTATAATATGTCAAAATACAAGTTTTTTTTTTTTACATCGTTTTAGTAAGTTAATTTCATTTATTTAC
3121 TTTGGAGCTATATTTCCACTTAGAAAAACTAAGGTAATTTTACAATATATGCTGAGATTAAAAACCAAGGTAAAAATGAT
3201 CAAACATATATGAAATTGAGTCTTAGATTTAATGAATTTCACTCGAAAATAAATGATCAGAAGAATTTTCATCTAAGGCA
3281 TAGAGTGGCGAAATTTTTGTAAATGCTCGCAGTTAGCATCTAACTAAAACAATACAGTATGACTTTATTTAGGAGAAGGC
3361 TTTTTATTTAGAAAATTATTTTTTCATTTTTACAGTGTATCAACTGTATCCATTTTCCTCACCTGGATAGTCAATGTTAT
3441 CTGAGCAGTTCAAGGAGTAACCAAGGCAACCTTATGTAATAACTTTCCATTCTTTATCCATACAAACTCTTTCAGTGCCC
3521 TAGATTCTAATGTTATAAACGTCAAACATCACTGCCCAACATAAATAAGACTCGAGACTTATTAACATAAATAAGTATCT
3601 TGCCTTCTTGAATGCTAGTTAAATGCTTAGATTTACCTAACTGCCTAATGAATCAGGTTATTTGTTAATAAGATTATTTT
3681 TCAAATTATTTAAGACCTTTATGCCCCTTCCAATTACTTGTGATTTGTAGGCCTGTAGGATTGTTGCATCTAATCTGACT
3761 GGCAACAGAAAATGTCATCAAATACTATAATATCCATTTTGTTTTCTTTTGCACTAATACAACAGAACATATCATTTTTG
3841 TTTTAAACAATGGTTAATATATTAATAGGGTTTGTTCCACACTTACTATTTATAGTTTTTATAATCAAGCATTGGGTATT
3921 AAAAGAGAATCCTTTCAACCCTTCATCTTCGTATGCTTATACAATAAATTGCAGTGAGTGT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauUGUGGUGUCACACCAAAc 5'
              |:|:|||  |||||||| 
Target 5' gaatATATCAC-CTGTGGTTTt 3'
 1982 - 2002 161.00 -14.90
2 
miRNA  3' agauugUGGUGUCACACCAAAc 5'
                |||| |  ||||||| 
Target 5' ttttcaACCA-A--GTGGTTTg 3'
 2388 - 2406 147.00 -14.60
3 
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            ||| |::::||| |||||| 
Target 5' tcTAAAATTGTAGTTTGGTTTg 3'
 1794 - 1815 144.00 -18.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31604720 11 COSMIC
COSN28888465 31 COSMIC
COSN30123887 43 COSMIC
COSN30452781 49 COSMIC
COSN30466900 50 COSMIC
COSN30761880 55 COSMIC
COSN20041307 63 COSMIC
COSN31561526 65 COSMIC
COSN30500985 76 COSMIC
COSN31548241 83 COSMIC
COSN30123188 107 COSMIC
COSN30111518 115 COSMIC
COSN30164432 137 COSMIC
COSN26553480 141 COSMIC
COSN7953035 166 COSMIC
COSN25868406 191 COSMIC
COSN30167737 193 COSMIC
COSN31529513 215 COSMIC
COSN31539998 260 COSMIC
COSN31545565 266 COSMIC
COSN9822361 329 COSMIC
COSN9920067 357 COSMIC
COSN25749101 374 COSMIC
COSN31962834 426 COSMIC
COSN17075881 427 COSMIC
COSN5644595 466 COSMIC
COSN16702922 677 COSMIC
COSN23708582 755 COSMIC
COSN32114087 1256 COSMIC
COSN15251495 1284 COSMIC
COSN15124145 1299 COSMIC
COSN2194129 1543 COSMIC
COSN20091669 1588 COSMIC
COSN30176521 1589 COSMIC
COSN7953036 1620 COSMIC
COSN9822362 1657 COSMIC
COSN24976362 1684 COSMIC
COSN31515114 1694 COSMIC
COSN29463572 1734 COSMIC
COSN2490714 2147 COSMIC
COSN27565958 2231 COSMIC
COSN20508321 2232 COSMIC
COSN31570214 2652 COSMIC
COSN31537146 2689 COSMIC
COSN31545073 2720 COSMIC
COSN30176570 2817 COSMIC
COSN26201426 2833 COSMIC
COSN6345455 2944 COSMIC
COSN27904451 3013 COSMIC
COSN9822363 3070 COSMIC
COSN20104666 3087 COSMIC
COSN14656061 3255 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1321055327 3 dbSNP
rs370885257 4 dbSNP
rs1478011648 8 dbSNP
rs1459183993 23 dbSNP
rs774500278 27 dbSNP
rs767437782 30 dbSNP
rs1479857211 31 dbSNP
rs534717224 33 dbSNP
rs1415106153 34 dbSNP
rs1475178728 35 dbSNP
rs1163459696 38 dbSNP
rs1167624254 40 dbSNP
rs1425106252 40 dbSNP
rs1025689061 43 dbSNP
rs1406897745 44 dbSNP
rs1330250882 49 dbSNP
rs1206473622 54 dbSNP
rs369434346 55 dbSNP
rs1019449907 56 dbSNP
rs372696698 59 dbSNP
rs1283173166 60 dbSNP
rs1217970321 66 dbSNP
rs955308423 75 dbSNP
rs546784977 77 dbSNP
rs911039082 79 dbSNP
rs1203884885 82 dbSNP
rs942544146 86 dbSNP
rs989827799 89 dbSNP
rs1028612306 93 dbSNP
rs187389132 94 dbSNP
rs377408387 96 dbSNP
rs1271587236 105 dbSNP
rs989537478 110 dbSNP
rs1041364659 123 dbSNP
rs760676564 129 dbSNP
rs1315665751 130 dbSNP
rs1436468146 133 dbSNP
rs369634988 133 dbSNP
rs1172729235 137 dbSNP
rs1021070462 138 dbSNP
rs1432642547 141 dbSNP
rs1471509621 148 dbSNP
rs966664453 153 dbSNP
rs538486704 157 dbSNP
rs1475898511 160 dbSNP
rs1386017580 165 dbSNP
rs1402514161 166 dbSNP
rs1332275332 168 dbSNP
rs1359030558 169 dbSNP
rs1191173043 170 dbSNP
rs1486918372 182 dbSNP
rs1258857391 189 dbSNP
rs1210544839 194 dbSNP
rs906899234 196 dbSNP
rs928230452 202 dbSNP
rs1214770434 209 dbSNP
rs938302946 213 dbSNP
rs190633827 225 dbSNP
rs990985936 229 dbSNP
rs939609096 233 dbSNP
rs183137880 244 dbSNP
rs1412929566 250 dbSNP
rs930840172 250 dbSNP
rs537042324 251 dbSNP
rs1228220525 258 dbSNP
rs1356049989 270 dbSNP
rs1278577867 272 dbSNP
rs555341967 273 dbSNP
rs1410717126 276 dbSNP
rs1351030990 286 dbSNP
rs1206317403 289 dbSNP
rs1275911871 290 dbSNP
rs73447417 293 dbSNP
rs1258754612 294 dbSNP
rs185648746 298 dbSNP
rs1187862882 299 dbSNP
rs1012843282 301 dbSNP
rs939654783 303 dbSNP
rs28450959 306 dbSNP
rs578107061 312 dbSNP
rs901085159 323 dbSNP
rs1481942347 325 dbSNP
rs1234515683 328 dbSNP
rs994287137 335 dbSNP
rs1180901292 338 dbSNP
rs1334914150 339 dbSNP
rs1292198038 340 dbSNP
rs1364530735 343 dbSNP
rs1375495873 348 dbSNP
rs879215346 360 dbSNP
rs545319503 364 dbSNP
rs564006238 365 dbSNP
rs1170841650 368 dbSNP
rs1394592124 388 dbSNP
rs141401543 389 dbSNP
rs1463276700 391 dbSNP
rs190110053 414 dbSNP
rs1369312679 415 dbSNP
rs1164348037 426 dbSNP
rs1409597218 427 dbSNP
rs986708620 436 dbSNP
rs1010749089 438 dbSNP
rs1018620075 440 dbSNP
rs966820478 446 dbSNP
rs1003542186 452 dbSNP
rs1468681598 457 dbSNP
rs963876442 459 dbSNP
rs1335922919 461 dbSNP
rs989942566 462 dbSNP
rs914447150 463 dbSNP
rs1272758775 467 dbSNP
rs1307638005 470 dbSNP
rs1370908092 477 dbSNP
rs967095194 480 dbSNP
rs1305432161 489 dbSNP
rs977172457 496 dbSNP
rs928305539 497 dbSNP
rs1325244965 507 dbSNP
rs938365169 515 dbSNP
rs560885312 518 dbSNP
rs1234457227 523 dbSNP
rs1056689782 528 dbSNP
rs959637550 543 dbSNP
rs1378830444 559 dbSNP
rs528167523 561 dbSNP
rs948164918 564 dbSNP
rs1038537769 565 dbSNP
rs546699440 569 dbSNP
rs994234774 570 dbSNP
rs1047607941 571 dbSNP
rs571291798 572 dbSNP
rs1454756018 576 dbSNP
rs1008650232 578 dbSNP
rs1175678753 581 dbSNP
rs1388788057 584 dbSNP
rs1282141594 603 dbSNP
rs1234772201 607 dbSNP
rs1371923383 609 dbSNP
rs1386750078 614 dbSNP
rs1302954324 616 dbSNP
rs1385374496 623 dbSNP
rs532322551 624 dbSNP
rs1432578694 625 dbSNP
rs1018150160 628 dbSNP
rs1359221076 630 dbSNP
rs550545422 631 dbSNP
rs1184111405 634 dbSNP
rs952175166 639 dbSNP
rs1173517266 640 dbSNP
rs983591599 642 dbSNP
rs1011483803 647 dbSNP
rs1139311 648 dbSNP
rs939810879 660 dbSNP
rs1040694124 662 dbSNP
rs1021403724 667 dbSNP
rs1254085073 669 dbSNP
rs1231307848 674 dbSNP
rs1309526630 684 dbSNP
rs527336673 688 dbSNP
rs1381744768 693 dbSNP
rs977117153 697 dbSNP
rs928387782 698 dbSNP
rs1416011908 701 dbSNP
rs1375211728 702 dbSNP
rs893734397 703 dbSNP
rs1010739355 708 dbSNP
rs1188549896 710 dbSNP
rs1197370370 710 dbSNP
rs1253781470 710 dbSNP
rs199577707 710 dbSNP
rs35602216 710 dbSNP
rs527793952 710 dbSNP
rs530132544 710 dbSNP
rs1042284677 713 dbSNP
rs1305002304 716 dbSNP
rs1339912997 720 dbSNP
rs1226640999 722 dbSNP
rs536148318 731 dbSNP
rs902582503 734 dbSNP
rs1316143815 739 dbSNP
rs1341187892 739 dbSNP
rs1332546312 743 dbSNP
rs9769337 743 dbSNP
rs71775608 744 dbSNP
rs1003658437 745 dbSNP
rs1207906614 745 dbSNP
rs112958987 747 dbSNP
rs150991171 747 dbSNP
rs533665524 751 dbSNP
rs9769338 751 dbSNP
rs71149778 754 dbSNP
rs1241885746 755 dbSNP
rs915612179 780 dbSNP
rs117455275 788 dbSNP
rs1309042772 790 dbSNP
rs766428834 795 dbSNP
rs1195516654 800 dbSNP
rs1272556431 802 dbSNP
rs1428402466 804 dbSNP
rs1460470089 806 dbSNP
rs1194486649 812 dbSNP
rs1160210185 820 dbSNP
rs959611022 821 dbSNP
rs1362975390 823 dbSNP
rs1012251378 835 dbSNP
rs1438005471 848 dbSNP
rs1038656023 854 dbSNP
rs1028288064 859 dbSNP
rs1451099513 861 dbSNP
rs1287903793 869 dbSNP
rs1456709044 870 dbSNP
rs1352100049 873 dbSNP
rs1285696401 874 dbSNP
rs920067891 879 dbSNP
rs1372638169 880 dbSNP
rs930138883 893 dbSNP
rs983578414 900 dbSNP
rs76149393 901 dbSNP
rs1319760090 902 dbSNP
rs961097539 906 dbSNP
rs976877393 908 dbSNP
rs1156566317 909 dbSNP
rs1436375800 910 dbSNP
rs922380633 912 dbSNP
rs1174495301 917 dbSNP
rs891205679 918 dbSNP
rs1477847399 920 dbSNP
rs1245034009 921 dbSNP
rs1008349670 935 dbSNP
rs1195449193 938 dbSNP
rs1448042961 939 dbSNP
rs1381212513 940 dbSNP
rs1296196223 943 dbSNP
rs183097440 949 dbSNP
rs751842243 955 dbSNP
rs1328202455 963 dbSNP
rs1231156461 975 dbSNP
rs932277393 979 dbSNP
rs116443309 980 dbSNP
rs1335664442 984 dbSNP
rs1342497373 984 dbSNP
rs1215824906 997 dbSNP
rs915161696 1000 dbSNP
rs946639594 1005 dbSNP
rs575976174 1008 dbSNP
rs1205859678 1021 dbSNP
rs1042231634 1038 dbSNP
rs1264391608 1042 dbSNP
rs902319556 1050 dbSNP
rs187712562 1056 dbSNP
rs1011432715 1059 dbSNP
rs1021518271 1060 dbSNP
rs1187616159 1071 dbSNP
rs1414075169 1076 dbSNP
rs967155757 1083 dbSNP
rs1423362843 1091 dbSNP
rs1169658239 1096 dbSNP
rs561597661 1101 dbSNP
rs1056911919 1103 dbSNP
rs895238922 1116 dbSNP
rs1423078321 1117 dbSNP
rs1192120057 1118 dbSNP
rs1486962565 1120 dbSNP
rs1035406945 1121 dbSNP
rs1419066431 1125 dbSNP
rs1476412856 1136 dbSNP
rs1274676311 1144 dbSNP
rs1214860559 1150 dbSNP
rs1166621966 1152 dbSNP
rs1275804386 1154 dbSNP
rs1356945451 1157 dbSNP
rs1235039762 1164 dbSNP
rs1356038671 1168 dbSNP
rs528080518 1174 dbSNP
rs1452428395 1175 dbSNP
rs370111023 1180 dbSNP
rs1357586107 1181 dbSNP
rs1386976654 1182 dbSNP
rs991281974 1185 dbSNP
rs1331116847 1189 dbSNP
rs1023034256 1195 dbSNP
rs963058131 1203 dbSNP
rs1412882573 1218 dbSNP
rs775886446 1228 dbSNP
rs540274504 1231 dbSNP
rs1005119395 1235 dbSNP
rs974293498 1236 dbSNP
rs192483810 1240 dbSNP
rs930087995 1246 dbSNP
rs983350652 1248 dbSNP
rs1415191836 1260 dbSNP
rs966144760 1265 dbSNP
rs1472009171 1267 dbSNP
rs6959930 1272 dbSNP
rs1235031754 1275 dbSNP
rs1204742979 1277 dbSNP
rs376231692 1282 dbSNP
rs1316559761 1283 dbSNP
rs550025439 1289 dbSNP
rs976286411 1290 dbSNP
rs1215056737 1293 dbSNP
rs912763567 1298 dbSNP
rs77874411 1302 dbSNP
rs1289078621 1305 dbSNP
rs1226592847 1316 dbSNP
rs1262586051 1318 dbSNP
rs767879325 1319 dbSNP
rs1482537941 1325 dbSNP
rs1210752959 1326 dbSNP
rs944108785 1334 dbSNP
rs1258890084 1347 dbSNP
rs1039815257 1352 dbSNP
rs1486852438 1353 dbSNP
rs899823626 1354 dbSNP
rs1029820722 1363 dbSNP
rs1376463426 1363 dbSNP
rs1329348378 1372 dbSNP
rs1463078658 1373 dbSNP
rs764305997 1374 dbSNP
rs1350912400 1384 dbSNP
rs1164690539 1388 dbSNP
rs953861546 1392 dbSNP
rs985512169 1398 dbSNP
rs914940302 1416 dbSNP
rs1438653213 1418 dbSNP
rs946379355 1423 dbSNP
rs1194895582 1425 dbSNP
rs977981073 1427 dbSNP
rs1488514932 1428 dbSNP
rs754015440 1437 dbSNP
rs1219244078 1442 dbSNP
rs923855714 1443 dbSNP
rs1042920935 1446 dbSNP
rs1306962393 1449 dbSNP
rs569964838 1457 dbSNP
rs1259921200 1461 dbSNP
rs769179317 1461 dbSNP
rs1353168411 1482 dbSNP
rs1307361671 1489 dbSNP
rs1443473700 1491 dbSNP
rs1368364405 1492 dbSNP
rs1293068641 1509 dbSNP
rs939147318 1513 dbSNP
rs532109000 1514 dbSNP
rs1348209242 1522 dbSNP
rs1405266437 1528 dbSNP
rs1056332614 1530 dbSNP
rs761901071 1532 dbSNP
rs998822763 1533 dbSNP
rs1378917277 1536 dbSNP
rs1035918787 1537 dbSNP
rs569819644 1538 dbSNP
rs1049036746 1542 dbSNP
rs887749190 1549 dbSNP
rs1365066716 1551 dbSNP
rs550708611 1560 dbSNP
rs1312183661 1565 dbSNP
rs1263816085 1579 dbSNP
rs1376066837 1582 dbSNP
rs755014415 1584 dbSNP
rs1282255938 1587 dbSNP
rs542292265 1588 dbSNP
rs377701758 1597 dbSNP
rs10237300 1599 dbSNP
rs1026022464 1601 dbSNP
rs1364630196 1617 dbSNP
rs1299332264 1624 dbSNP
rs1400001413 1625 dbSNP
rs1358989391 1626 dbSNP
rs1315244784 1632 dbSNP
rs1466186439 1634 dbSNP
rs752935105 1636 dbSNP
rs951600249 1639 dbSNP
rs1173255305 1641 dbSNP
rs1429784220 1649 dbSNP
rs1423784212 1654 dbSNP
rs1309469635 1655 dbSNP
rs1345784618 1656 dbSNP
rs950393908 1658 dbSNP
rs1233740114 1659 dbSNP
rs752607425 1670 dbSNP
rs548058342 1687 dbSNP
rs944240404 1689 dbSNP
rs1483664091 1697 dbSNP
rs1255644083 1699 dbSNP
rs975876634 1701 dbSNP
rs953915836 1705 dbSNP
rs1208354843 1707 dbSNP
rs1202801436 1713 dbSNP
rs1278960857 1716 dbSNP
rs1006613307 1723 dbSNP
rs756674536 1728 dbSNP
rs1295456477 1729 dbSNP
rs1232687871 1738 dbSNP
rs921356684 1742 dbSNP
rs1396974398 1752 dbSNP
rs947350896 1753 dbSNP
rs1400973831 1754 dbSNP
rs1480085017 1757 dbSNP
rs1177396064 1766 dbSNP
rs1252291792 1767 dbSNP
rs1452026072 1768 dbSNP
rs1463258953 1771 dbSNP
rs563671602 1784 dbSNP
rs1022073405 1810 dbSNP
rs1476778623 1816 dbSNP
rs1419949072 1834 dbSNP
rs903227246 1840 dbSNP
rs1187928400 1844 dbSNP
rs755866256 1852 dbSNP
rs534695460 1854 dbSNP
rs1436529601 1864 dbSNP
rs1168004276 1873 dbSNP
rs1353672848 1878 dbSNP
rs895608067 1886 dbSNP
rs1012757446 1897 dbSNP
rs1300105328 1903 dbSNP
rs977759263 1906 dbSNP
rs150126680 1908 dbSNP
rs898911861 1909 dbSNP
rs1440181845 1912 dbSNP
rs778091146 1924 dbSNP
rs1246242115 1928 dbSNP
rs1340240418 1935 dbSNP
rs1311094364 1939 dbSNP
rs1025971898 1940 dbSNP
rs950437957 1945 dbSNP
rs1213358559 1951 dbSNP
rs1330013651 1959 dbSNP
rs1262929429 1963 dbSNP
rs1004848550 1970 dbSNP
rs138417761 1977 dbSNP
rs965898339 1979 dbSNP
rs184032580 1981 dbSNP
rs557505340 1983 dbSNP
rs921473554 1987 dbSNP
rs187863710 1992 dbSNP
rs1466868855 1993 dbSNP
rs1178030699 1999 dbSNP
rs548923730 2005 dbSNP
rs1049109911 2007 dbSNP
rs924589599 2011 dbSNP
rs555295765 2013 dbSNP
rs1478746043 2019 dbSNP
rs1057400873 2020 dbSNP
rs1418783571 2021 dbSNP
rs1264009015 2030 dbSNP
rs909310132 2031 dbSNP
rs573623657 2033 dbSNP
rs948683786 2034 dbSNP
rs778437844 2042 dbSNP
rs774955407 2059 dbSNP
rs902077043 2059 dbSNP
rs1323701989 2062 dbSNP
rs1386096218 2068 dbSNP
rs746355659 2071 dbSNP
rs994572172 2072 dbSNP
rs1160017161 2073 dbSNP
rs1420094789 2074 dbSNP
rs1047530867 2077 dbSNP
rs1158263937 2082 dbSNP
rs772629404 2084 dbSNP
rs1008570918 2090 dbSNP
rs370543107 2093 dbSNP
rs1051133576 2104 dbSNP
rs1181277711 2105 dbSNP
rs564735573 2107 dbSNP
rs756757604 2113 dbSNP
rs1219509724 2114 dbSNP
rs997090904 2119 dbSNP
rs1488819461 2121 dbSNP
rs576836062 2122 dbSNP
rs1285807327 2125 dbSNP
rs1237481214 2129 dbSNP
rs1028436214 2133 dbSNP
rs1011756264 2138 dbSNP
rs1231897112 2141 dbSNP
rs1329217258 2141 dbSNP
rs1022018034 2148 dbSNP
rs967822162 2150 dbSNP
rs968874867 2155 dbSNP
rs978784873 2159 dbSNP
rs1296165798 2161 dbSNP
rs1030694281 2167 dbSNP
rs1173179359 2176 dbSNP
rs1477734049 2190 dbSNP
rs1376061396 2191 dbSNP
rs1270117766 2200 dbSNP
rs775978376 2203 dbSNP
rs575792072 2206 dbSNP
rs768923034 2210 dbSNP
rs1216630506 2217 dbSNP
rs1055521 2232 dbSNP
rs1214946245 2235 dbSNP
rs1332161144 2237 dbSNP
rs1443716910 2241 dbSNP
rs1212647960 2245 dbSNP
rs992840174 2249 dbSNP
rs1278906627 2254 dbSNP
rs1199579802 2255 dbSNP
rs1342251691 2256 dbSNP
rs17137546 2260 dbSNP
rs558109813 2268 dbSNP
rs1213114340 2275 dbSNP
rs1227789178 2276 dbSNP
rs1339782887 2284 dbSNP
rs948651347 2293 dbSNP
rs1449976375 2295 dbSNP
rs1359589229 2297 dbSNP
rs1335099169 2302 dbSNP
rs578111819 2310 dbSNP
rs1403975643 2311 dbSNP
rs548021734 2311 dbSNP
rs1466562154 2313 dbSNP
rs1423542030 2315 dbSNP
rs930477342 2319 dbSNP
rs1191880666 2330 dbSNP
rs1484184675 2333 dbSNP
rs1473970895 2337 dbSNP
rs1238476849 2339 dbSNP
rs1047479720 2341 dbSNP
rs537221244 2342 dbSNP
rs140240418 2344 dbSNP
rs780000850 2349 dbSNP
rs765384315 2350 dbSNP
rs746744097 2351 dbSNP
rs868225671 2364 dbSNP
rs1259372336 2366 dbSNP
rs1198735739 2377 dbSNP
rs909298768 2379 dbSNP
rs1009104778 2382 dbSNP
rs1160067174 2391 dbSNP
rs1256069850 2398 dbSNP
rs940802443 2400 dbSNP
rs1040034529 2408 dbSNP
rs527590587 2409 dbSNP
rs1283432789 2411 dbSNP
rs546940527 2416 dbSNP
rs773483694 2419 dbSNP
rs923270804 2421 dbSNP
rs933337877 2422 dbSNP
rs1447625698 2423 dbSNP
rs1399722965 2424 dbSNP
rs759540405 2431 dbSNP
rs1398954578 2444 dbSNP
rs997029980 2449 dbSNP
rs1414945326 2463 dbSNP
rs1163062725 2465 dbSNP
rs1442348790 2479 dbSNP
rs1239636459 2485 dbSNP
rs1050662404 2486 dbSNP
rs889375816 2488 dbSNP
rs1028544150 2489 dbSNP
rs13237006 2498 dbSNP
rs1000320600 2502 dbSNP
rs1032296239 2504 dbSNP
rs1288834425 2511 dbSNP
rs1226403502 2517 dbSNP
rs1346253638 2521 dbSNP
rs1043284852 2523 dbSNP
rs1311721789 2525 dbSNP
rs903585293 2528 dbSNP
rs1311636016 2542 dbSNP
rs539053083 2548 dbSNP
rs1234345758 2551 dbSNP
rs993350136 2554 dbSNP
rs1358035015 2558 dbSNP
rs1423119174 2569 dbSNP
rs1024289843 2570 dbSNP
rs1382627158 2572 dbSNP
rs970065538 2579 dbSNP
rs867437184 2586 dbSNP
rs979988446 2606 dbSNP
rs1438749276 2608 dbSNP
rs1405102995 2614 dbSNP
rs1192462550 2619 dbSNP
rs1221517368 2636 dbSNP
rs550783298 2637 dbSNP
rs569417219 2638 dbSNP
rs192019459 2651 dbSNP
rs930424957 2654 dbSNP
rs1218669579 2669 dbSNP
rs983304406 2676 dbSNP
rs1489145657 2682 dbSNP
rs184214422 2684 dbSNP
rs1241113416 2685 dbSNP
rs1353285032 2686 dbSNP
rs1304908247 2694 dbSNP
rs1485216411 2695 dbSNP
rs1221018279 2698 dbSNP
rs1368473854 2702 dbSNP
rs1274775871 2703 dbSNP
rs1013671338 2720 dbSNP
rs117617725 2721 dbSNP
rs573535934 2724 dbSNP
rs1299217212 2726 dbSNP
rs534237843 2731 dbSNP
rs969750606 2742 dbSNP
rs944460563 2743 dbSNP
rs1177530393 2744 dbSNP
rs1040552034 2768 dbSNP
rs984571386 2770 dbSNP
rs1016079720 2779 dbSNP
rs558497399 2812 dbSNP
rs961868935 2813 dbSNP
rs1478788206 2814 dbSNP
rs1215664856 2817 dbSNP
rs6949658 2817 dbSNP
rs753501565 2827 dbSNP
rs931655185 2833 dbSNP
rs756954688 2834 dbSNP
rs1049926731 2836 dbSNP
rs189012002 2842 dbSNP
rs947639935 2855 dbSNP
rs1043232151 2857 dbSNP
rs1279165479 2875 dbSNP
rs903322478 2879 dbSNP
rs934834395 2885 dbSNP
rs1000438529 2892 dbSNP
rs896231151 2902 dbSNP
rs1173657708 2907 dbSNP
rs1467079898 2912 dbSNP
rs1031825362 2915 dbSNP
rs891982074 2916 dbSNP
rs200216769 2917 dbSNP
rs1023745949 2925 dbSNP
rs1014316019 2932 dbSNP
rs1350743342 2935 dbSNP
rs1183798148 2936 dbSNP
rs1241763487 2939 dbSNP
rs867525788 2942 dbSNP
rs1483714064 2944 dbSNP
rs1024824827 2945 dbSNP
rs905106239 2952 dbSNP
rs771052500 2953 dbSNP
rs970013238 2954 dbSNP
rs1320553251 2955 dbSNP
rs6949846 2958 dbSNP
rs1027699109 2961 dbSNP
rs1227423714 2963 dbSNP
rs6950016 2975 dbSNP
rs983804516 2982 dbSNP
rs1396197553 2987 dbSNP
rs1435903100 2994 dbSNP
rs1334038701 2998 dbSNP
rs907684153 2999 dbSNP
rs1400479873 3008 dbSNP
rs6950334 3017 dbSNP
rs975821660 3021 dbSNP
rs954996755 3022 dbSNP
rs1165258433 3023 dbSNP
rs774353778 3031 dbSNP
rs1242776309 3032 dbSNP
rs1182043743 3041 dbSNP
rs1459139817 3047 dbSNP
rs1441616057 3055 dbSNP
rs986129214 3056 dbSNP
rs768750713 3057 dbSNP
rs931769436 3059 dbSNP
rs1267561441 3072 dbSNP
rs1491017155 3075 dbSNP
rs201868523 3075 dbSNP
rs35145743 3075 dbSNP
rs775013871 3075 dbSNP
rs947380872 3076 dbSNP
rs1043365212 3078 dbSNP
rs903557203 3081 dbSNP
rs551568528 3087 dbSNP
rs934780608 3087 dbSNP
rs1394947782 3088 dbSNP
rs1435910960 3089 dbSNP
rs1174637689 3090 dbSNP
rs1394743545 3092 dbSNP
rs936247328 3093 dbSNP
rs1161866623 3097 dbSNP
rs1053797465 3099 dbSNP
rs1336053647 3101 dbSNP
rs1380939055 3103 dbSNP
rs1181220771 3121 dbSNP
rs891935437 3131 dbSNP
rs1436509977 3149 dbSNP
rs896219348 3152 dbSNP
rs949186885 3153 dbSNP
rs559933131 3155 dbSNP
rs745452552 3158 dbSNP
rs904846458 3166 dbSNP
rs1300650364 3175 dbSNP
rs905944766 3180 dbSNP
rs527555310 3184 dbSNP
rs1278379746 3187 dbSNP
rs1236274710 3188 dbSNP
rs1027646703 3193 dbSNP
rs1332380735 3199 dbSNP
rs1301893787 3200 dbSNP
rs1404296585 3210 dbSNP
rs952051047 3214 dbSNP
rs1004780991 3218 dbSNP
rs1299827871 3220 dbSNP
rs552167361 3232 dbSNP
rs1421705679 3237 dbSNP
rs564440562 3243 dbSNP
rs1158007774 3245 dbSNP
rs79069122 3246 dbSNP
rs897781746 3247 dbSNP
rs1200174926 3255 dbSNP
rs976316086 3272 dbSNP
rs1480410273 3274 dbSNP
rs1273895709 3277 dbSNP
rs993340109 3282 dbSNP
rs1030601495 3287 dbSNP
rs757913282 3290 dbSNP
rs780486890 3291 dbSNP
rs1203081173 3293 dbSNP
rs1346463193 3300 dbSNP
rs1252486554 3302 dbSNP
rs953118619 3304 dbSNP
rs1008025252 3307 dbSNP
rs1287205026 3309 dbSNP
rs747498719 3310 dbSNP
rs1400397716 3312 dbSNP
rs968667339 3317 dbSNP
rs17137551 3326 dbSNP
rs924848043 3331 dbSNP
rs1475290662 3334 dbSNP
rs1168860370 3337 dbSNP
rs1177284870 3344 dbSNP
rs1469679153 3351 dbSNP
rs956299477 3351 dbSNP
rs569323674 3354 dbSNP
rs935004529 3359 dbSNP
rs62470671 3360 dbSNP
rs748388706 3383 dbSNP
rs950369623 3397 dbSNP
rs1303312246 3401 dbSNP
rs1045177275 3404 dbSNP
rs770207743 3407 dbSNP
rs138491185 3412 dbSNP
rs1356003849 3413 dbSNP
rs1321263036 3424 dbSNP
rs567090639 3433 dbSNP
rs906061166 3440 dbSNP
rs941693685 3441 dbSNP
rs773573791 3447 dbSNP
rs1212025904 3456 dbSNP
rs1347041533 3463 dbSNP
rs1428844336 3472 dbSNP
rs1342492297 3476 dbSNP
rs1337406340 3478 dbSNP
rs1001602748 3487 dbSNP
rs1037370768 3493 dbSNP
rs1404089856 3497 dbSNP
rs1173422812 3499 dbSNP
rs367713861 3500 dbSNP
rs534431828 3503 dbSNP
rs897727589 3505 dbSNP
rs17585463 3507 dbSNP
rs1384219217 3508 dbSNP
rs1051697286 3513 dbSNP
rs760994034 3519 dbSNP
rs1446947521 3531 dbSNP
rs890259435 3538 dbSNP
rs577506660 3541 dbSNP
rs1007395384 3542 dbSNP
rs1426186550 3543 dbSNP
rs1474456718 3546 dbSNP
rs17137554 3549 dbSNP
rs1199142443 3556 dbSNP
rs1437199214 3558 dbSNP
rs1270541371 3561 dbSNP
rs1473689379 3564 dbSNP
rs1416800451 3566 dbSNP
rs1457908927 3569 dbSNP
rs1294784436 3570 dbSNP
rs968822870 3572 dbSNP
rs966346255 3574 dbSNP
rs1298777119 3575 dbSNP
rs540283868 3580 dbSNP
rs1231293235 3582 dbSNP
rs1333469422 3584 dbSNP
rs1443507677 3587 dbSNP
rs547167797 3587 dbSNP
rs775459773 3588 dbSNP
rs953230644 3592 dbSNP
rs979121478 3598 dbSNP
rs1442446138 3604 dbSNP
rs1381585265 3605 dbSNP
rs993464744 3608 dbSNP
rs1247015138 3609 dbSNP
rs1469513782 3610 dbSNP
rs1231090959 3616 dbSNP
rs1259068735 3625 dbSNP
rs1485606030 3631 dbSNP
rs1206210997 3633 dbSNP
rs1223767223 3652 dbSNP
rs1266042560 3655 dbSNP
rs925043005 3665 dbSNP
rs1221958729 3697 dbSNP
rs1357591638 3698 dbSNP
rs375525751 3701 dbSNP
rs1224417431 3706 dbSNP
rs1372768968 3711 dbSNP
rs760573273 3713 dbSNP
rs1278290337 3719 dbSNP
rs1439268696 3734 dbSNP
rs1366559135 3736 dbSNP
rs956361606 3744 dbSNP
rs763930512 3752 dbSNP
rs1422294411 3756 dbSNP
rs115471522 3788 dbSNP
rs950337804 3806 dbSNP
rs1483585269 3811 dbSNP
rs1159456440 3812 dbSNP
rs541548128 3814 dbSNP
rs980274885 3817 dbSNP
rs1405220672 3820 dbSNP
rs926374339 3821 dbSNP
rs1192829891 3826 dbSNP
rs114425978 3831 dbSNP
rs191480588 3833 dbSNP
rs1197016484 3834 dbSNP
rs918892190 3854 dbSNP
rs929004181 3862 dbSNP
rs546022134 3865 dbSNP
rs1052076585 3866 dbSNP
rs764487696 3878 dbSNP
rs552100250 3882 dbSNP
rs1316379480 3885 dbSNP
rs937507413 3896 dbSNP
rs1038923969 3902 dbSNP
rs1049133764 3909 dbSNP
rs546083295 3910 dbSNP
rs1361529395 3912 dbSNP
rs1346703506 3916 dbSNP
rs753397243 3921 dbSNP
rs904595289 3921 dbSNP
rs1255634561 3927 dbSNP
rs887854812 3933 dbSNP
rs940817767 3937 dbSNP
rs564222813 3939 dbSNP
rs1036756231 3941 dbSNP
rs143092734 3942 dbSNP
rs76734784 3946 dbSNP
rs1439817680 3951 dbSNP
rs1028879450 3952 dbSNP
rs562884132 3961 dbSNP
rs1000658531 3963 dbSNP
rs1428528666 3964 dbSNP
rs1380103234 3969 dbSNP
rs1032176934 3971 dbSNP
rs891753212 3981 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000393486.1 | 3UTR | CCUUUUUACUUUAACCAAAUCUACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.373 3.6e-2 -0.368 3.8e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.329 5.4e-2 -0.301 7.2e-2 25 Click to see details
GSE32688 Pancreatic cancer -0.226 1.1e-1 -0.240 9.3e-2 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.2 1.7e-1 0.147 2.5e-1 24 Click to see details
GSE21687 Ependynoma primary tumors 0.093 2.3e-1 0.083 2.6e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.143 2.7e-1 -0.232 1.6e-1 20 Click to see details
GSE38226 Liver fibrosis -0.1 3.3e-1 -0.268 1.2e-1 21 Click to see details
GSE42095 Differentiated embryonic stem cells -0.091 3.4e-1 -0.162 2.3e-1 23 Click to see details
GSE28260 Renal cortex and medulla 0.095 3.8e-1 0.106 3.7e-1 13 Click to see details
GSE17498 Multiple myeloma 0.022 4.5e-1 -0.131 2.1e-1 40 Click to see details
GSE19350 CNS germ cell tumors 0.011 4.9e-1 0.259 2.1e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.011 4.9e-1 0.259 2.1e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.011 4.9e-1 0.259 2.1e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.578 0 0.548 0 30 Click to see details
PAAD 0.882 0.06 0.800 0.1 4 Click to see details
LUAD -0.855 0.07 -1.000 0.5 4 Click to see details
KICH -0.309 0.13 -0.229 0.21 15 Click to see details
BRCA -0.147 0.18 -0.126 0.21 42 Click to see details
CHOL 0.446 0.19 0.257 0.31 6 Click to see details
ESCA 0.294 0.2 0.600 0.03 10 Click to see details
KIRP -0.183 0.21 -0.178 0.22 21 Click to see details
HNSC 0.078 0.38 -0.028 0.46 18 Click to see details
LIHC 0.051 0.39 0.083 0.33 30 Click to see details
KIRC 0.031 0.42 0.056 0.36 43 Click to see details
STAD 0.042 0.43 0.177 0.22 21 Click to see details
UCEC 0.037 0.45 0.109 0.34 16 Click to see details
BLCA 0.047 0.48 -0.200 0.4 4 Click to see details
THCA 0.008 0.48 -0.009 0.48 45 Click to see details
PRAD -0.003 0.49 0.057 0.35 46 Click to see details
PRAD -0.003 0.49 0.057 0.35 46 Click to see details
PRAD -0.003 0.49 0.057 0.35 46 Click to see details
PRAD -0.003 0.49 0.057 0.35 46 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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