pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KANSL1   
Synonyms CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1
Description KAT8 regulatory NSL complex subunit 1
Transcript NM_015443   
Expression
Putative miRNA Targets on KANSL1
3'UTR of KANSL1
(miRNA target sites are highlighted)
>KANSL1|NM_015443|3'UTR
   1 GCGGGAGACAGCCATCTAAACAGACTCACTAACTATTGGCATTAAAGCTTCAGAAATCTCTGCGTTTGATATTCAAACAT
  81 CATATGCCGGAAATTTTCACAGTTTTTAGTGAACTTAAGGAATTTAGATCCTACTTTGGTATTTTTTTTTCTTGTTTTAA
 161 TTTTTGTTTTGTTTTTGTTTCCATGTTTTCTTGTCACACACCTGAGCACTTCCTCCCGTTGGCAAACAGAAGTTCAGGAT
 241 GAGACCCTGCTGGCCTGGTCCTGGCACATCCTCTGCACTGTTGAATCACTGGACTTACTGATCTTAGATGACCACCCCCT
 321 CCCTCACACCTGTGGGCAGGGCAGAACAGCCTGGCGGGCTACAGTTTAGCATGGCCTTCTTGAGCTAGGGTGGAATGGGG
 401 CAGGGTGCTCTGGACTCTTACCCCCTCCCCTCCCATCTGTGGCTTGGCTCTGCTGTGGCCCTCCTGGCTGGGTCCCCTTG
 481 GTTTTTCGTGCTGGAACATCCCCACCAGAGCCTCTCTGCCATAACTGCCAGCTGCTCTCCCCGAGTGCTCAGCTGGCAGA
 561 ACACCTTTCCTTTCTCACCCAGAACTTAAGAGACTGATTTTTTGTTTCATCTGCATTTGGTCTTCTCTGTTTTGACTCTT
 641 TCACTGCAGTAACCTGGCTGTGGCTGCTCAGGTTCCCCTCCTCATGCCCCTTGGTACCCTTCCCTGTCTGCTCTCCCATG
 721 CCATGTACACACCCACAACCCGTCCTTCCACTTGGAATATTTTTACCACCTATCCTGATCTTTGAAGGTAGGGTTAGGAC
 801 TACTTAACCTCTATTCCCACTCCCCTGCAAACTGGGGGTTGTGGGAAGTGAGCAGCCATCTCCCTGTGTGATTTTTTTTT
 881 TTTTTCCCTCTGATTCACTTTGCCATGTTTCCTTCACATCCAGATCCCTGTCGGTGTTAGTTCCACTCTTGGTCTTTCAC
 961 GCTCCCCTTGCCTGTGGAACATTGTCTGGTCCTAGCTGTGGTTCCCATTGTTCCCCCTTCACCCTTCTCTGTTAACCTTG
1041 TGCCTGTCTCCTGTATGATCACATCACCAAAAAGGGGGAGGGGGGAGAAGACTCTTTTTTTTTGGCCATTTTGTAATCGT
1121 ATAAAAATAGTAGACAACTGCTTAATGGTTGGGGTTTTTTCACAATTTTCAACATTAGTGATTTTTTTTTCTGTTTGCAA
1201 GTTAAAGGGTTTGTCATTGTTTCTTTAAAAAAAAATACAATAATGCACCATATCCCTATGCATAAAGTGCTTCTTCTATT
1281 TATAAGGTTGAAAATTCTGAATAACCCTTTTAGCATTGAAAAAAAAAACAAAAACAAAAAATGGAAAAAAAAAACCTTGT
1361 ATTTTGTAAATATTTTCTTTTCCTGCTTTGGAGCTGTGTAATGGCAGCGAAACATGTAGCTGTCTTTGTTCTATAGAAAT
1441 GCTTTTCTTCAGAGAAGCTGATCTTTGTTAATGTCTTGATTCTGTTCGCAAAGCACAGACTAGTGCTTAAAAAAAAAAAA
1521 GAAGGAAAAATTGAAAAAAATAAAAAAAAAAGTTACAGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuaggaccaagacaggGAGUGAUc 5'
                           ||||||| 
Target 5' acagccatctaaacagaCTCACTAa 3'
8 - 32 140.00 -9.40
2
miRNA  3' cuuAGGACCAAGAC--AGGGAGUGAUc 5'
             ||:  |||:||  ||::|||||: 
Target 5' tctTCTCTGTTTTGACTCTTTCACTGc 3'
621 - 647 140.00 -16.10
3
miRNA  3' cuuaGGACCAAGAC-----AGG-GA-GUGAUc 5'
              |||||| |||     ||| || ||||: 
Target 5' ctggCCTGGTCCTGGCACATCCTCTGCACTGt 3'
250 - 281 125.00 -21.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
391464 2 ClinVar
381968 3 ClinVar
323761 36 ClinVar
323760 38 ClinVar
323759 217 ClinVar
323758 360 ClinVar
323757 388 ClinVar
323756 487 ClinVar
323754 626 ClinVar
323752 640 ClinVar
323751 742 ClinVar
323749 886 ClinVar
323748 954 ClinVar
323746 1027 ClinVar
323745 1028 ClinVar
323744 1104 ClinVar
323743 1196 ClinVar
323741 1236 ClinVar
323742 1236 ClinVar
323738 1329 ClinVar
323735 1355 ClinVar
323736 1355 ClinVar
323731 1521 ClinVar
323732 1521 ClinVar
323730 1552 ClinVar
COSN23669300 3 COSMIC
COSN30480583 5 COSMIC
COSN31542880 63 COSMIC
COSN31598717 63 COSMIC
COSN30176262 68 COSMIC
COSN31518995 88 COSMIC
COSN31491287 120 COSMIC
COSN22816383 141 COSMIC
COSN28878956 142 COSMIC
COSN4769228 241 COSMIC
COSN31579872 253 COSMIC
COSN20114044 355 COSMIC
COSN25784081 401 COSMIC
COSN25229791 540 COSMIC
COSN16073428 542 COSMIC
COSN8837408 703 COSMIC
COSN20114043 871 COSMIC
COSN28988513 872 COSMIC
COSN22555722 876 COSMIC
COSN8837407 984 COSMIC
COSN20114042 1226 COSMIC
COSN31548922 1231 COSMIC
COSN29586879 1318 COSMIC
COSN20114040 1319 COSMIC
COSN31489110 1478 COSMIC
COSN31517507 1487 COSMIC
COSN20114038 1509 COSMIC
COSN24306242 1541 COSMIC
COSN24305899 1542 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1173885709 1 dbSNP
rs774194245 2 dbSNP
rs372125138 3 dbSNP
rs901807508 4 dbSNP
rs1361944933 7 dbSNP
rs775460035 8 dbSNP
rs769590171 9 dbSNP
rs1304244642 10 dbSNP
rs746012943 15 dbSNP
rs1231071714 16 dbSNP
rs567243937 17 dbSNP
rs776352811 18 dbSNP
rs1449330951 19 dbSNP
rs1323279372 25 dbSNP
rs1331969624 26 dbSNP
rs747161928 30 dbSNP
rs1377535849 31 dbSNP
rs768138439 31 dbSNP
rs1335580355 35 dbSNP
rs767896466 36 dbSNP
rs373668834 38 dbSNP
rs1168911624 41 dbSNP
rs778296615 45 dbSNP
rs553624358 47 dbSNP
rs1229182895 48 dbSNP
rs1182791468 51 dbSNP
rs1275311912 56 dbSNP
rs1020982547 60 dbSNP
rs943068318 63 dbSNP
rs1266402208 84 dbSNP
rs1429596239 84 dbSNP
rs1201057168 86 dbSNP
rs752732089 88 dbSNP
rs1245766208 89 dbSNP
rs1448378807 93 dbSNP
rs546370187 114 dbSNP
rs1423274696 115 dbSNP
rs1043475663 134 dbSNP
rs76025910 141 dbSNP
rs778823729 145 dbSNP
rs78288850 150 dbSNP
rs1001626132 151 dbSNP
rs1035821925 151 dbSNP
rs905971553 151 dbSNP
rs1448700368 154 dbSNP
rs947552634 162 dbSNP
rs913401170 167 dbSNP
rs1282036143 171 dbSNP
rs1299903735 177 dbSNP
rs1367349996 181 dbSNP
rs989036321 182 dbSNP
rs754855855 183 dbSNP
rs1242519535 184 dbSNP
rs1356812096 185 dbSNP
rs938927477 190 dbSNP
rs1211367233 193 dbSNP
rs928904706 201 dbSNP
rs1265892709 207 dbSNP
rs763093998 208 dbSNP
rs1006660959 209 dbSNP
rs980084725 216 dbSNP
rs140200874 217 dbSNP
rs1016332766 218 dbSNP
rs1421485926 218 dbSNP
rs985292957 219 dbSNP
rs1284169061 229 dbSNP
rs1369518617 231 dbSNP
rs1459806070 241 dbSNP
rs1225521194 249 dbSNP
rs1421249799 255 dbSNP
rs1388256066 264 dbSNP
rs1047456876 266 dbSNP
rs929907898 268 dbSNP
rs1404017743 269 dbSNP
rs1395477046 270 dbSNP
rs1311962418 281 dbSNP
rs1340955898 284 dbSNP
rs950545981 287 dbSNP
rs1026563610 290 dbSNP
rs750626539 297 dbSNP
rs1328130044 298 dbSNP
rs557530485 298 dbSNP
rs537145609 300 dbSNP
rs759242187 304 dbSNP
rs1347488375 308 dbSNP
rs767649413 315 dbSNP
rs865959422 318 dbSNP
rs868488291 319 dbSNP
rs1269577623 320 dbSNP
rs1457049015 320 dbSNP
rs1407230915 322 dbSNP
rs1482009195 323 dbSNP
rs112051212 325 dbSNP
rs1257544953 329 dbSNP
rs910997692 335 dbSNP
rs1180558476 347 dbSNP
rs1017498972 351 dbSNP
rs776107572 353 dbSNP
rs1432398390 355 dbSNP
rs1007157801 356 dbSNP
rs200384907 356 dbSNP
rs113448888 360 dbSNP
rs978494820 363 dbSNP
rs903544100 366 dbSNP
rs1423995525 367 dbSNP
rs1161676422 377 dbSNP
rs1357603344 378 dbSNP
rs1186644514 380 dbSNP
rs968821569 385 dbSNP
rs367998611 388 dbSNP
rs1402893449 391 dbSNP
rs1240311755 398 dbSNP
rs1306049294 399 dbSNP
rs1349678512 401 dbSNP
rs1228740369 405 dbSNP
rs762158298 407 dbSNP
rs945125361 408 dbSNP
rs988842186 415 dbSNP
rs1256070945 419 dbSNP
rs1483909414 420 dbSNP
rs892252377 421 dbSNP
rs182071752 422 dbSNP
rs554651362 423 dbSNP
rs1035877419 424 dbSNP
rs763541489 426 dbSNP
rs1001678553 428 dbSNP
rs1184745162 429 dbSNP
rs938858367 432 dbSNP
rs751575389 439 dbSNP
rs970184139 440 dbSNP
rs144386890 442 dbSNP
rs149673847 448 dbSNP
rs1427849690 450 dbSNP
rs1166679142 451 dbSNP
rs948671739 452 dbSNP
rs909219514 455 dbSNP
rs191706665 460 dbSNP
rs1300792640 461 dbSNP
rs764279233 466 dbSNP
rs1006298467 467 dbSNP
rs532137925 471 dbSNP
rs186913097 474 dbSNP
rs17652961 487 dbSNP
rs965867183 488 dbSNP
rs35349036 504 dbSNP
rs1017445052 510 dbSNP
rs1207807016 512 dbSNP
rs1007437326 519 dbSNP
rs901106157 521 dbSNP
rs1407471957 530 dbSNP
rs549897622 532 dbSNP
rs942536883 537 dbSNP
rs1192020827 542 dbSNP
rs182060151 543 dbSNP
rs776007238 547 dbSNP
rs1358239634 559 dbSNP
rs1389541779 565 dbSNP
rs1430326919 566 dbSNP
rs1170655045 568 dbSNP
rs1347917130 571 dbSNP
rs560953214 578 dbSNP
rs1293781873 582 dbSNP
rs1022378860 585 dbSNP
rs1432321323 588 dbSNP
rs1009271335 589 dbSNP
rs1043237843 590 dbSNP
rs1366641816 590 dbSNP
rs1216831083 592 dbSNP
rs1321531498 596 dbSNP
rs139454638 596 dbSNP
rs1222737832 604 dbSNP
rs886053067 608 dbSNP
rs912938302 610 dbSNP
rs770095702 611 dbSNP
rs1244859288 621 dbSNP
rs533537317 626 dbSNP
rs1482784109 627 dbSNP
rs959677140 629 dbSNP
rs886053066 637 dbSNP
rs17574361 640 dbSNP
rs1423067890 642 dbSNP
rs1205417776 657 dbSNP
rs1165188895 659 dbSNP
rs1309474040 669 dbSNP
rs1396293466 675 dbSNP
rs1272661187 682 dbSNP
rs776223913 682 dbSNP
rs1455310090 684 dbSNP
rs1282514469 688 dbSNP
rs770486856 690 dbSNP
rs1319388066 693 dbSNP
rs907384123 703 dbSNP
rs1044634669 706 dbSNP
rs1432242851 713 dbSNP
rs551056408 716 dbSNP
rs948953208 717 dbSNP
rs909500431 721 dbSNP
rs1049518868 724 dbSNP
rs1379054616 729 dbSNP
rs929346121 732 dbSNP
rs1384251780 733 dbSNP
rs1327441487 738 dbSNP
rs1208363443 741 dbSNP
rs7350928 742 dbSNP
rs1208068358 744 dbSNP
rs985327203 748 dbSNP
rs950838851 751 dbSNP
rs1378809972 757 dbSNP
rs976204534 764 dbSNP
rs1471453999 765 dbSNP
rs1157990723 770 dbSNP
rs1443999029 777 dbSNP
rs1412215385 783 dbSNP
rs1401989962 787 dbSNP
rs1352397062 790 dbSNP
rs1331608292 799 dbSNP
rs1359162538 800 dbSNP
rs965815496 808 dbSNP
rs1026792301 809 dbSNP
rs1349043891 811 dbSNP
rs1167457716 813 dbSNP
rs886053065 816 dbSNP
rs577559225 824 dbSNP
rs1019574491 825 dbSNP
rs1443008596 832 dbSNP
rs1006808933 833 dbSNP
rs910386118 835 dbSNP
rs561989638 838 dbSNP
rs1470956437 845 dbSNP
rs891562125 846 dbSNP
rs947181405 846 dbSNP
rs967932272 857 dbSNP
rs1022242826 858 dbSNP
rs1369211640 861 dbSNP
rs1409650576 863 dbSNP
rs1178727267 864 dbSNP
rs1481766320 871 dbSNP
rs77877023 872 dbSNP
rs1009631186 884 dbSNP
rs1249866659 885 dbSNP
rs1339958463 886 dbSNP
rs1434585074 886 dbSNP
rs1491039734 886 dbSNP
rs35400776 886 dbSNP
rs560103470 886 dbSNP
rs5820607 886 dbSNP
rs1204262345 887 dbSNP
rs1204549020 887 dbSNP
rs1273450983 889 dbSNP
rs928298669 889 dbSNP
rs1294589261 890 dbSNP
rs1245732240 892 dbSNP
rs1243175652 893 dbSNP
rs980362743 896 dbSNP
rs1388920449 904 dbSNP
rs1429664812 905 dbSNP
rs1169709832 906 dbSNP
rs1399097922 913 dbSNP
rs1403903828 913 dbSNP
rs1323176145 916 dbSNP
rs1331879115 923 dbSNP
rs777125731 926 dbSNP
rs1295491013 932 dbSNP
rs557566678 933 dbSNP
rs1308243548 952 dbSNP
rs150500194 954 dbSNP
rs1251771407 958 dbSNP
rs1035154991 960 dbSNP
rs113829708 961 dbSNP
rs1207814485 961 dbSNP
rs1245667353 964 dbSNP
rs1448289477 966 dbSNP
rs1194546439 967 dbSNP
rs1375244012 970 dbSNP
rs1003302717 974 dbSNP
rs1472036779 976 dbSNP
rs1306982817 977 dbSNP
rs1391814861 979 dbSNP
rs1405036374 981 dbSNP
rs866247914 988 dbSNP
rs984993270 991 dbSNP
rs1388031807 992 dbSNP
rs1366831878 997 dbSNP
rs1296262192 1000 dbSNP
rs1328108860 1004 dbSNP
rs950928013 1007 dbSNP
rs1283374622 1013 dbSNP
rs1457407843 1017 dbSNP
rs1234761537 1020 dbSNP
rs748062988 1022 dbSNP
rs11870461 1027 dbSNP
rs375427074 1028 dbSNP
rs976154695 1031 dbSNP
rs888008383 1037 dbSNP
rs534663923 1040 dbSNP
rs1410068430 1043 dbSNP
rs754764162 1046 dbSNP
rs1017619560 1047 dbSNP
rs919270859 1048 dbSNP
rs749102622 1050 dbSNP
rs1208129234 1052 dbSNP
rs1007531685 1055 dbSNP
rs565649466 1060 dbSNP
rs1488461949 1062 dbSNP
rs1411474243 1063 dbSNP
rs1261803681 1064 dbSNP
rs1241652562 1065 dbSNP
rs1327435716 1067 dbSNP
rs1287340918 1068 dbSNP
rs944788271 1069 dbSNP
rs910672963 1070 dbSNP
rs28553921 1073 dbSNP
rs985915837 1075 dbSNP
rs558466127 1080 dbSNP
rs946596612 1081 dbSNP
rs1385716313 1082 dbSNP
rs779954172 1088 dbSNP
rs757396562 1093 dbSNP
rs1290513929 1094 dbSNP
rs1261978881 1095 dbSNP
rs189466615 1096 dbSNP
rs374923391 1096 dbSNP
rs548139198 1096 dbSNP
rs1455445474 1098 dbSNP
rs1044049608 1102 dbSNP
rs1180446465 1104 dbSNP
rs1419888412 1104 dbSNP
rs142756815 1104 dbSNP
rs948363123 1104 dbSNP
rs1387559131 1106 dbSNP
rs569545053 1116 dbSNP
rs1480924159 1118 dbSNP
rs988090327 1118 dbSNP
rs956540674 1119 dbSNP
rs1375958374 1128 dbSNP
rs1196910599 1132 dbSNP
rs1305951899 1133 dbSNP
rs549673929 1137 dbSNP
rs1034695431 1138 dbSNP
rs1391626960 1140 dbSNP
rs1432617318 1143 dbSNP
rs929522902 1149 dbSNP
rs11539537 1154 dbSNP
rs1231857039 1161 dbSNP
rs1281732907 1163 dbSNP
rs1263052852 1165 dbSNP
rs751844327 1168 dbSNP
rs764036245 1176 dbSNP
rs758494380 1183 dbSNP
rs1179189919 1186 dbSNP
rs1395677016 1191 dbSNP
rs910610046 1191 dbSNP
rs986148064 1191 dbSNP
rs1436513631 1192 dbSNP
rs1267969567 1193 dbSNP
rs968435320 1195 dbSNP
rs137970866 1196 dbSNP
rs1462269664 1204 dbSNP
rs1299572676 1207 dbSNP
rs1365029617 1213 dbSNP
rs567201128 1221 dbSNP
rs887963961 1227 dbSNP
rs1272671932 1232 dbSNP
rs140510364 1236 dbSNP
rs955940898 1236 dbSNP
rs1308475611 1237 dbSNP
rs1028286613 1240 dbSNP
rs1263948668 1244 dbSNP
rs1488270523 1245 dbSNP
rs1031926441 1250 dbSNP
rs547375618 1251 dbSNP
rs556641274 1255 dbSNP
rs527324885 1259 dbSNP
rs183793920 1272 dbSNP
rs1186630691 1276 dbSNP
rs1447680884 1276 dbSNP
rs771885571 1278 dbSNP
rs1394911635 1282 dbSNP
rs1428955485 1283 dbSNP
rs1172256764 1284 dbSNP
rs993765382 1285 dbSNP
rs1347830462 1286 dbSNP
rs886053064 1287 dbSNP
rs552931988 1288 dbSNP
rs1326091736 1290 dbSNP
rs898109168 1291 dbSNP
rs1396054075 1295 dbSNP
rs541570663 1304 dbSNP
rs886053063 1306 dbSNP
rs1288837011 1307 dbSNP
rs1363244997 1316 dbSNP
rs1432879209 1318 dbSNP
rs1311021467 1319 dbSNP
rs1334549258 1320 dbSNP
rs1044105690 1322 dbSNP
rs1012563461 1329 dbSNP
rs1208167600 1329 dbSNP
rs71665335 1329 dbSNP
rs887429997 1329 dbSNP
rs1364363028 1330 dbSNP
rs1049356938 1333 dbSNP
rs1470819669 1335 dbSNP
rs1474728842 1335 dbSNP
rs1455232817 1336 dbSNP
rs1317001949 1338 dbSNP
rs929549668 1339 dbSNP
rs1040343025 1340 dbSNP
rs1301554430 1341 dbSNP
rs1355262577 1341 dbSNP
rs1415748605 1342 dbSNP
rs1295404304 1343 dbSNP
rs532837667 1344 dbSNP
rs1327327198 1345 dbSNP
rs1223360311 1346 dbSNP
rs886053062 1350 dbSNP
rs563924578 1354 dbSNP
rs1217885374 1355 dbSNP
rs1485243815 1355 dbSNP
rs67641084 1355 dbSNP
rs886053061 1355 dbSNP
rs1465619864 1356 dbSNP
rs1259249695 1370 dbSNP
rs1471403209 1373 dbSNP
rs1373777177 1383 dbSNP
rs11539536 1389 dbSNP
rs1190590475 1398 dbSNP
rs760101658 1402 dbSNP
rs1040576904 1408 dbSNP
rs1375351409 1409 dbSNP
rs781388886 1409 dbSNP
rs7502673 1410 dbSNP
rs543626880 1414 dbSNP
rs915088423 1415 dbSNP
rs1315177862 1417 dbSNP
rs886053060 1433 dbSNP
rs886053059 1434 dbSNP
rs776847930 1442 dbSNP
rs1280305941 1444 dbSNP
rs574879269 1464 dbSNP
rs1276069084 1468 dbSNP
rs1375653613 1471 dbSNP
rs986202187 1481 dbSNP
rs1278162237 1487 dbSNP
rs147415592 1488 dbSNP
rs1282203616 1493 dbSNP
rs1047606 1495 dbSNP
rs1435817118 1501 dbSNP
rs1199465338 1502 dbSNP
rs759428148 1505 dbSNP
rs1233070500 1518 dbSNP
rs935260350 1519 dbSNP
rs75210291 1520 dbSNP
rs11539535 1521 dbSNP
rs1455092333 1521 dbSNP
rs67801660 1521 dbSNP
rs75187918 1521 dbSNP
rs886053058 1521 dbSNP
rs915224810 1521 dbSNP
rs968110171 1521 dbSNP
rs988123041 1523 dbSNP
rs1339640463 1524 dbSNP
rs1356471550 1524 dbSNP
rs769319125 1525 dbSNP
rs1371735394 1526 dbSNP
rs142803832 1532 dbSNP
rs1031523000 1541 dbSNP
rs1305486957 1541 dbSNP
rs1002681481 1542 dbSNP
rs1315586365 1545 dbSNP
rs1022702747 1552 dbSNP
rs1273345732 1552 dbSNP
rs1439193045 1552 dbSNP
rs767830420 1552 dbSNP
rs886053057 1552 dbSNP
rs887493893 1552 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 284058.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuuaggaccaagacaggGAGUGAUc 5'
                           ||||||| 
Target 5' ----ccaucuaaacagaCUCACUAa 3'
1 - 21
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000574590.1 | 3UTR | CCAUCUAAACAGACUCACUAACUAUUGGCAUUAAAGCUUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000574590.1 | 3UTR | CCAUCUAAACAGACUCACUAACUAUUGGCAUUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000574590.1 | 3UTR | ACUCACUAACUAUUGGCAUUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000574590.1 | 3UTR | ACUCACUAACUAUUGGCAUUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.812 3.7e-4 0.769 1.1e-3 13 Click to see details
GSE19783 ER+ ER+ breast cancer 0.606 2.3e-3 0.498 1.3e-2 20 Click to see details
GSE28544 Breast cancer 0.312 6.9e-2 0.448 1.4e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.224 1.5e-1 0.232 1.4e-1 23 Click to see details
GSE19350 CNS germ cell tumors 0.285 1.8e-1 0.364 1.2e-1 12 Click to see details
GSE19783 ER- ER- breast cancer -0.096 2.0e-1 -0.060 3.0e-1 79 Click to see details
GSE21687 Ependynoma primary tumors 0.096 2.3e-1 -0.072 2.9e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.12 2.8e-1 -0.218 1.5e-1 25 Click to see details
GSE19536 Breast cancer 0.057 2.9e-1 0.082 2.1e-1 100 Click to see details
GSE38226 Liver fibrosis -0.097 3.4e-1 -0.074 3.7e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.074 3.7e-1 -0.039 4.3e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.07 3.8e-1 0.326 8.0e-2 20 Click to see details
GSE32688 Pancreatic cancer 0.013 4.7e-1 0.116 2.6e-1 32 Click to see details
GSE32688 Pancreatic cancer 0.013 4.7e-1 0.116 2.6e-1 32 Click to see details
GSE32688 Pancreatic cancer 0.013 4.7e-1 0.116 2.6e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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