pre-miRNA Information
pre-miRNA hsa-mir-3160-1   
Genomic Coordinates chr11: 46451805 - 46451889
Description Homo sapiens miR-3160-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3160-2   
Genomic Coordinates chr11: 46451807 - 46451887
Description Homo sapiens miR-3160-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3160-3p
Sequence 54| AGAGCUGAGACUAGAAAGCCCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30582333 1 COSMIC
COSN1535547 3 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1396368683 1 dbSNP
rs1162409303 2 dbSNP
rs1404378453 12 dbSNP
rs1171960732 14 dbSNP
rs1324633375 16 dbSNP
rs1187765019 16 dbSNP
rs1300058326 19 dbSNP
rs1432898407 21 dbSNP
rs1011279103 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ICOSLG   
Synonyms B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
Description inducible T-cell costimulator ligand
Transcript NM_015259   
Expression
Putative miRNA Targets on ICOSLG
3'UTR of ICOSLG
(miRNA target sites are highlighted)
>ICOSLG|NM_015259|3'UTR
   1 CCGGAGCTCACCGCCCAGAGCGTGGACAGGGCTTCCGTGAGACGCCACCGTGAGAGGCCAGGTGGCAGCTTGAGCATGGA
  81 CTCCCAGACTGCAGGGGAGCACTTGGGGCAGCCCCCAGAAGGACCACTGCTGGATCCCAGGGAGAACCTGCTGGCGTTGG
 161 CTGTGATCCTGGAATGAGGCCCTTTCAAAAGCGTCATCCACACCAAAGGCAAATGTCCCCAAGTGAGTGGGCTCCCCGCT
 241 GTCACTGCCAGTCACCCACAGGAAGGGACTGGTGATGGGCTGTCTCTACCCGGAGCGTGCGGGATTCAGCACCAGGCTCT
 321 TCCCAGTACCCCAGACCCACTGTGGGTCTTCCCGTGGGATGCGGGATCCTGAGACCGAAGGGTGTTTGGTTTAAAAAGAA
 401 GACTGGGCGTCCGCTCTTCCAGGACGGCCTCTGTGCTGCTGGGGTCACGCGAGGCTGTTTGCAGGGGACACGGTCACAGG
 481 AGCTCTTCTGCCCTGAACGCTCCCAACCTGCCTCCCGCCCGGAAGCCACAGGACCCACTCATGTGTGTGCCCACAAGTGT
 561 AGTTAGCCGTCCACACCGAGGAGCCCCCGGAAGTCCCCACTGGGCTTCAGTGTCCTCTGCCACATTCCCTGGGAGGAACA
 641 ATGTCCCTCGGCTGTTCCGGTGAAAAGTTGAGCCACCTTTGGAAGACGCACGGGTGGAGTTTGCCAGAAGAAAGGCTGTG
 721 CCAGGGCCGTGTTTGGCTACAGGGGCTGCCGGGGCTCTTGGCTCTGCAGCGAGAAAGACACAGCCCAGCAGGGCTGGAGA
 801 CGCCCATGTCCAGCAGGCGCAGGCCTGGCAACACGGTCCCCAGAGTCCTGAGCAGCAGTTAGGTGCATGGAGAGGGTATC
 881 ACCTGGTGGCCACAGTCCCCCTTCTCACCTCAGCAATGATCCCCAAAGTGAGAGGTGGCTCCCCCGGCCCCCACCACCCT
 961 CAGCAGCCCCACCCCACTCAACCCTGAGGGTCCCCAGGGTCCTGATGAAGACCTCCGACCCCAGCGCCAGGCTCCTCGGA
1041 GCCCAACAGTCCCAAGGGGGCAGGAGACGGGGTGGTCCAGTGCTGAGGGGTACAGCCCTGGGCCCTGACCAGCCCCGGCA
1121 CCTGCCATGCTGGTTCCCGGAATGAATCAGCTGCTGACTGTCTCCAGAAGGGCTGGAAAGGATGCTGCCAGGTGACCCGA
1201 GGTGCACTCGCCCCAGGGAGATGGAGTAGACAGCCTGGCCTGGCCCTCGGGACACATTGTCTGCCCCGGGGCTATGGGCA
1281 AATGCCCCTCCTTCTTACTTCCCAGAATCCCCTGACATTCCCAGGGTCAGCCAGGACCTGTTACAGCCCTGGTCACTTGG
1361 AACTGACAGCTGTGTGAGGCCTGCACTTCTCAGACCCAGACTTAGAACAAAAGGAGGAGTGAGGACTCAAGGCTACAATG
1441 AGGTTCCAGTACTTGTTACAAGAAATTGGTTTTCTGCAAAAAAAGTCCCTACCTGAGCCTTTAGGTGAATGTGGGATCCA
1521 CTCCCGCTTTTAACATGAAAGCATTAGAAGATGTGTGGTGTTTATAAAAGAACAGTTGTCATCACCGGGCATTGATTGGC
1601 AGGGACAAGGAGCTGCTTGGGTGTGGAAAGTTGGGGCGTTGGAAAGTGGGCTGTGGTGCCCATTTGCAGTGACTGTGAAG
1681 TGACTCCAGGACGGACCTGCGGGGGCACCCAGAGGTCCTAAGCCCCAGGACTGAGGGTCGTGCATCACCACTCGGGTGTC
1761 CCGGGAGGTGCCCTGGGCCCGGGGACCTCACAGGCAGGACGGCGACACTAATGCAGGGAGAGGGAGTCTGGCCCCAGCTT
1841 TTCCTATCAGAGGCGATTTTCCTTCACCAGGGGATGGGCAGGAAAGAGGCAGGGGCCCCAGAAGCTTCTGTCCCTCATGC
1921 CTGAGGGCACGGGGGACACTTGGAGGCTGCTGTCACCACTGTGCGTCCAAGGCCATGCTCTCTGCGGGTCAGTGCCTGAG
2001 TCTCGCCTCCCTGCTGGTCCCTGAAGCCCCCTCAGAAGCCCTGCCTGTCACGTCGGCATTTGTGAGACCTACCCTGTAAC
2081 GCCTGCCCCTCTCAGCCCAACATCAGCTTCCTCTTTCTCCCTTGCTGTAGACAGGCTGGATTCCAGTGTTGGGACAGCCA
2161 TCTCCAGAAACCTGACTTAAGAGAGTAAGATGCAAATCGTGCCTGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acCCGAAAGAUC--AGAGUCGAGa 5'
            ||||  | :|  |||::|||| 
Target 5' ggGGCTGCCGGGGCTCTTGGCTCt 3'
742 - 765 130.00 -21.30
2
miRNA  3' acccGAAAGAUCAG-----AGUCGAGa 5'
              || || || |     ||||||: 
Target 5' gcccCTCTC-AGCCCAACATCAGCTTc 3'
2085 - 2110 129.00 -7.56
3
miRNA  3' accCGAAAGAUCAGAGUCGAGa 5'
             || | | :| :||||| | 
Target 5' ggaGCGTGCGGGATTCAGCACc 3'
292 - 313 123.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30467978 3 COSMIC
COSN30160836 8 COSMIC
COSN30136025 12 COSMIC
COSN8892091 37 COSMIC
COSN31536875 65 COSMIC
COSN30129644 109 COSMIC
COSN30126626 113 COSMIC
COSN31590801 155 COSMIC
COSN28641969 227 COSMIC
COSN14589768 296 COSMIC
COSN5453855 319 COSMIC
COSN8011884 521 COSMIC
COSN20117067 1061 COSMIC
COSN21224866 1229 COSMIC
COSN26260689 1931 COSMIC
COSN25780906 2281 COSMIC
COSN1893985 2443 COSMIC
COSN23273960 3162 COSMIC
COSN20121399 3389 COSMIC
COSN23296763 3476 COSMIC
COSN32170303 4073 COSMIC
COSN26449318 4115 COSMIC
COSN23868533 4139 COSMIC
COSN1893984 4287 COSMIC
COSN4784018 5140 COSMIC
COSN8008153 5170 COSMIC
COSN18883791 5284 COSMIC
COSN25328797 5434 COSMIC
COSN23751878 5474 COSMIC
COSN26882423 5537 COSMIC
COSN1893983 5556 COSMIC
COSN1257416 5621 COSMIC
COSN28873387 5706 COSMIC
COSN19750409 5909 COSMIC
COSM9488778 5959 COSMIC
COSM2820519 5983 COSMIC
COSN1257415 5985 COSMIC
rs4819388 1496 GWAS
rs8131653 4233 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773386846 2 dbSNP
rs115284714 3 dbSNP
rs1216438743 5 dbSNP
rs751607847 7 dbSNP
rs777702099 11 dbSNP
rs56292769 12 dbSNP
rs371186534 13 dbSNP
rs753482288 20 dbSNP
rs766074961 21 dbSNP
rs574896704 22 dbSNP
rs772599488 24 dbSNP
rs757216807 29 dbSNP
rs1387108556 30 dbSNP
rs763392423 32 dbSNP
rs530038535 36 dbSNP
rs55769116 37 dbSNP
rs758201467 43 dbSNP
rs374725627 44 dbSNP
rs1422225035 48 dbSNP
rs370580154 49 dbSNP
rs777742375 50 dbSNP
rs1296441782 54 dbSNP
rs1383977029 56 dbSNP
rs1377322479 59 dbSNP
rs778571156 65 dbSNP
rs1302481836 90 dbSNP
rs999451236 95 dbSNP
rs901183786 102 dbSNP
rs1019842818 106 dbSNP
rs1175465191 113 dbSNP
rs114182853 114 dbSNP
rs1439030066 116 dbSNP
rs1372406654 119 dbSNP
rs889948601 122 dbSNP
rs576603938 123 dbSNP
rs1048627830 134 dbSNP
rs1367558204 136 dbSNP
rs931048726 156 dbSNP
rs564531333 161 dbSNP
rs1297709631 171 dbSNP
rs1186704560 178 dbSNP
rs546323373 192 dbSNP
rs572434670 193 dbSNP
rs1282860109 224 dbSNP
rs980023707 238 dbSNP
rs948672432 291 dbSNP
rs914401675 292 dbSNP
rs989978545 296 dbSNP
rs74841947 297 dbSNP
rs535751529 299 dbSNP
rs575124078 300 dbSNP
rs1273422191 309 dbSNP
rs56335306 312 dbSNP
rs1031018813 324 dbSNP
rs1415573912 329 dbSNP
rs867182006 330 dbSNP
rs1357572592 337 dbSNP
rs1314545374 338 dbSNP
rs1407749714 345 dbSNP
rs556469563 351 dbSNP
rs1007136672 353 dbSNP
rs753411290 354 dbSNP
rs1463079207 355 dbSNP
rs1366148861 359 dbSNP
rs570711445 362 dbSNP
rs1475356168 363 dbSNP
rs551829551 376 dbSNP
rs533660567 378 dbSNP
rs1437608904 381 dbSNP
rs897341236 388 dbSNP
rs182577295 389 dbSNP
rs1487560254 400 dbSNP
rs548198266 401 dbSNP
rs755649984 412 dbSNP
rs1233950628 416 dbSNP
rs529943362 426 dbSNP
rs3804033 429 dbSNP
rs948659746 444 dbSNP
rs147715450 448 dbSNP
rs914458454 449 dbSNP
rs1054316390 450 dbSNP
rs1329476511 451 dbSNP
rs373640783 453 dbSNP
rs924473272 461 dbSNP
rs1392157361 463 dbSNP
rs760109152 488 dbSNP
rs1461498601 491 dbSNP
rs1419667635 498 dbSNP
rs1156417138 499 dbSNP
rs1469959742 504 dbSNP
rs965880440 515 dbSNP
rs577733070 516 dbSNP
rs985826281 517 dbSNP
rs954078510 521 dbSNP
rs1027210714 528 dbSNP
rs995777504 532 dbSNP
rs1252905102 540 dbSNP
rs1214470788 541 dbSNP
rs1469827443 543 dbSNP
rs370485408 549 dbSNP
rs961519609 552 dbSNP
rs1432179504 556 dbSNP
rs1323131859 564 dbSNP
rs868366298 565 dbSNP
rs565091301 569 dbSNP
rs906984242 577 dbSNP
rs1044152545 578 dbSNP
rs546303070 585 dbSNP
rs892824435 588 dbSNP
rs73907125 589 dbSNP
rs934610254 599 dbSNP
rs560282615 603 dbSNP
rs1368774442 614 dbSNP
rs147073178 632 dbSNP
rs556766720 633 dbSNP
rs1441015118 646 dbSNP
rs1395962733 649 dbSNP
rs189862656 658 dbSNP
rs912604647 663 dbSNP
rs1399717755 672 dbSNP
rs371585030 687 dbSNP
rs1160710446 688 dbSNP
rs954002814 691 dbSNP
rs1395012971 692 dbSNP
rs558764426 693 dbSNP
rs773262312 714 dbSNP
rs919948462 717 dbSNP
rs1194744718 728 dbSNP
rs533622881 750 dbSNP
rs751201545 751 dbSNP
rs1192519963 764 dbSNP
rs1447846156 765 dbSNP
rs1015766291 768 dbSNP
rs185152562 771 dbSNP
rs547867821 773 dbSNP
rs536206333 793 dbSNP
rs1012694273 796 dbSNP
rs892793477 801 dbSNP
rs1032674007 802 dbSNP
rs568763491 806 dbSNP
rs180834866 818 dbSNP
rs532482519 822 dbSNP
rs567599378 823 dbSNP
rs571445225 824 dbSNP
rs944508312 829 dbSNP
rs112574542 835 dbSNP
rs1457138516 839 dbSNP
rs1050253909 840 dbSNP
rs527776084 848 dbSNP
rs1174847796 867 dbSNP
rs560591897 883 dbSNP
rs974106471 889 dbSNP
rs1417961287 895 dbSNP
rs541959068 916 dbSNP
rs1437277276 924 dbSNP
rs908752079 935 dbSNP
rs1475781753 942 dbSNP
rs1244067201 945 dbSNP
rs530074191 946 dbSNP
rs1185622466 947 dbSNP
rs1484581223 958 dbSNP
rs772062260 961 dbSNP
rs1256492850 963 dbSNP
rs1211296426 998 dbSNP
rs1023165351 1004 dbSNP
rs1449865604 1005 dbSNP
rs1282034257 1008 dbSNP
rs865812188 1010 dbSNP
rs1270791903 1016 dbSNP
rs991193208 1025 dbSNP
rs957158497 1026 dbSNP
rs1271590923 1030 dbSNP
rs1032726209 1036 dbSNP
rs1228802357 1037 dbSNP
rs187117830 1038 dbSNP
rs902870542 1041 dbSNP
rs1019254141 1054 dbSNP
rs1327007348 1057 dbSNP
rs1207973036 1061 dbSNP
rs544490090 1063 dbSNP
rs1008838860 1068 dbSNP
rs1416992744 1069 dbSNP
rs573913488 1073 dbSNP
rs55873166 1076 dbSNP
rs1237093411 1077 dbSNP
rs1170284252 1078 dbSNP
rs55853339 1080 dbSNP
rs11274942 1081 dbSNP
rs67226187 1081 dbSNP
rs761261225 1081 dbSNP
rs775935106 1081 dbSNP
rs780593238 1081 dbSNP
rs117576800 1083 dbSNP
rs56026500 1084 dbSNP
rs796765206 1084 dbSNP
rs1163091170 1088 dbSNP
rs1475027441 1096 dbSNP
rs1418821354 1116 dbSNP
rs558725698 1117 dbSNP
rs1048369166 1120 dbSNP
rs1484072293 1122 dbSNP
rs1410132459 1126 dbSNP
rs1231119590 1127 dbSNP
rs1203672839 1136 dbSNP
rs1437932610 1137 dbSNP
rs540466826 1138 dbSNP
rs3827253 1139 dbSNP
rs182126616 1156 dbSNP
rs1293525156 1158 dbSNP
rs982090454 1165 dbSNP
rs950366279 1167 dbSNP
rs1298131390 1170 dbSNP
rs1402348563 1172 dbSNP
rs535986454 1199 dbSNP
rs1356757806 1206 dbSNP
rs1415662443 1209 dbSNP
rs1324026366 1210 dbSNP
rs916062315 1211 dbSNP
rs1460975636 1218 dbSNP
rs1395497045 1223 dbSNP
rs991579075 1235 dbSNP
rs957543176 1238 dbSNP
rs1167292145 1239 dbSNP
rs1425357016 1240 dbSNP
rs115685804 1245 dbSNP
rs1176375904 1248 dbSNP
rs778819071 1249 dbSNP
rs1470497851 1257 dbSNP
rs376109809 1261 dbSNP
rs1239917122 1264 dbSNP
rs770583045 1267 dbSNP
rs967428952 1268 dbSNP
rs15927 1271 dbSNP
rs1009221180 1272 dbSNP
rs953358593 1275 dbSNP
rs1272389986 1278 dbSNP
rs1029325510 1284 dbSNP
rs1315543021 1296 dbSNP
rs538929900 1303 dbSNP
rs1277953716 1330 dbSNP
rs994637652 1340 dbSNP
rs8130802 1346 dbSNP
rs1376240223 1360 dbSNP
rs1482916293 1362 dbSNP
rs1301792717 1367 dbSNP
rs1200258358 1405 dbSNP
rs1440278558 1416 dbSNP
rs1038446180 1426 dbSNP
rs1004330662 1448 dbSNP
rs1328209550 1455 dbSNP
rs1477304095 1459 dbSNP
rs9976668 1462 dbSNP
rs1170305159 1477 dbSNP
rs546923638 1479 dbSNP
rs527341479 1480 dbSNP
rs887102941 1485 dbSNP
rs4819388 1496 dbSNP
rs58690004 1503 dbSNP
rs916132051 1508 dbSNP
rs530172602 1511 dbSNP
rs1382103957 1525 dbSNP
rs1368512346 1526 dbSNP
rs562880745 1538 dbSNP
rs80027278 1558 dbSNP
rs1453296041 1563 dbSNP
rs936148886 1571 dbSNP
rs1253042672 1575 dbSNP
rs926146292 1586 dbSNP
rs752317037 1587 dbSNP
rs1259770689 1588 dbSNP
rs1230887693 1589 dbSNP
rs866453141 1611 dbSNP
rs532660194 1619 dbSNP
rs1342945089 1620 dbSNP
rs1230974142 1626 dbSNP
rs1356225810 1632 dbSNP
rs911544809 1635 dbSNP
rs1278837954 1636 dbSNP
rs1234149616 1637 dbSNP
rs372553184 1638 dbSNP
rs1372323082 1641 dbSNP
rs540528127 1666 dbSNP
rs1269835892 1667 dbSNP
rs1305776434 1668 dbSNP
rs573358886 1674 dbSNP
rs755587895 1680 dbSNP
rs188822626 1692 dbSNP
rs1028883788 1693 dbSNP
rs1431222589 1696 dbSNP
rs1387959887 1697 dbSNP
rs542684860 1700 dbSNP
rs749276820 1701 dbSNP
rs1392541879 1706 dbSNP
rs1362168940 1710 dbSNP
rs4819387 1715 dbSNP
rs1385067194 1716 dbSNP
rs1322805440 1723 dbSNP
rs1014801860 1725 dbSNP
rs556985591 1726 dbSNP
rs1437394393 1730 dbSNP
rs1004704589 1731 dbSNP
rs1341730551 1735 dbSNP
rs887160639 1737 dbSNP
rs183989755 1739 dbSNP
rs113222980 1740 dbSNP
rs571264070 1753 dbSNP
rs1260623974 1754 dbSNP
rs1186695816 1762 dbSNP
rs1489492790 1763 dbSNP
rs1427569013 1770 dbSNP
rs1187796470 1776 dbSNP
rs1055952307 1780 dbSNP
rs936285341 1781 dbSNP
rs926115198 1797 dbSNP
rs1349302909 1800 dbSNP
rs540720314 1801 dbSNP
rs1041907782 1803 dbSNP
rs553273354 1804 dbSNP
rs1396901614 1813 dbSNP
rs911609303 1815 dbSNP
rs1225337274 1816 dbSNP
rs1269117391 1823 dbSNP
rs1331841035 1830 dbSNP
rs534626246 1832 dbSNP
rs1265756401 1833 dbSNP
rs1485256614 1834 dbSNP
rs529556451 1836 dbSNP
rs1257863719 1840 dbSNP
rs921628654 1843 dbSNP
rs73381375 1849 dbSNP
rs1473567274 1850 dbSNP
rs1014854953 1853 dbSNP
rs1156856333 1854 dbSNP
rs1466600911 1855 dbSNP
rs983271488 1859 dbSNP
rs1310896980 1861 dbSNP
rs1400369895 1864 dbSNP
rs113619423 1866 dbSNP
rs1376069699 1868 dbSNP
rs1352699416 1870 dbSNP
rs1304452056 1878 dbSNP
rs181047945 1885 dbSNP
rs1371956330 1891 dbSNP
rs1014779624 1895 dbSNP
rs894466019 1896 dbSNP
rs1170496409 1910 dbSNP
rs1034346940 1913 dbSNP
rs1415187640 1917 dbSNP
rs3746961 1927 dbSNP
rs1187756524 1930 dbSNP
rs1000401044 1931 dbSNP
rs1258886252 1934 dbSNP
rs1194539016 1944 dbSNP
rs1480368899 1961 dbSNP
rs1209694342 1964 dbSNP
rs904744849 1965 dbSNP
rs543714872 1967 dbSNP
rs1220525357 1968 dbSNP
rs1179990367 1973 dbSNP
rs1333040057 1975 dbSNP
rs1042366545 1982 dbSNP
rs550671266 1985 dbSNP
rs867427513 1986 dbSNP
rs1434397206 1994 dbSNP
rs1308857301 2004 dbSNP
rs890635305 2005 dbSNP
rs532326081 2011 dbSNP
rs1314806161 2018 dbSNP
rs564962350 2019 dbSNP
rs1389642908 2022 dbSNP
rs1221380699 2023 dbSNP
rs1302849347 2025 dbSNP
rs931759484 2028 dbSNP
rs1345117417 2048 dbSNP
rs1395655971 2051 dbSNP
rs921597296 2052 dbSNP
rs1343800075 2054 dbSNP
rs188496544 2055 dbSNP
rs941685582 2067 dbSNP
rs528810659 2080 dbSNP
rs374366377 2081 dbSNP
rs970570404 2086 dbSNP
rs1362178000 2089 dbSNP
rs1453836196 2094 dbSNP
rs184669736 2097 dbSNP
rs564749405 2101 dbSNP
rs542893769 2102 dbSNP
rs958821053 2119 dbSNP
rs1034399403 2121 dbSNP
rs751397866 2124 dbSNP
rs1180072262 2126 dbSNP
rs575804355 2134 dbSNP
rs1419054285 2136 dbSNP
rs563323382 2148 dbSNP
rs1439304653 2152 dbSNP
rs904543346 2154 dbSNP
rs1292263521 2158 dbSNP
rs1467143713 2165 dbSNP
rs1272804909 2167 dbSNP
rs545143183 2168 dbSNP
rs1358696177 2171 dbSNP
rs1285779713 2179 dbSNP
rs1297638624 2192 dbSNP
rs1236590915 2198 dbSNP
rs577676620 2209 dbSNP
rs6518352 2219 dbSNP
rs562964028 2220 dbSNP
rs890622232 2228 dbSNP
rs1368084505 2253 dbSNP
rs1324842308 2258 dbSNP
rs1052405576 2265 dbSNP
rs1405637416 2273 dbSNP
rs1223729971 2279 dbSNP
rs932142941 2298 dbSNP
rs1037468385 2304 dbSNP
rs759540865 2313 dbSNP
rs941654517 2321 dbSNP
rs192233026 2322 dbSNP
rs779535100 2323 dbSNP
rs1447954787 2325 dbSNP
rs907564530 2326 dbSNP
rs983376274 2328 dbSNP
rs34714133 2333 dbSNP
rs949362933 2341 dbSNP
rs917754814 2346 dbSNP
rs991021021 2347 dbSNP
rs758094565 2349 dbSNP
rs959206860 2350 dbSNP
rs1458163489 2367 dbSNP
rs927350194 2368 dbSNP
rs555531975 2374 dbSNP
rs978832184 2377 dbSNP
rs75473822 2380 dbSNP
rs544679938 2384 dbSNP
rs879796922 2385 dbSNP
rs1010486990 2402 dbSNP
rs189190673 2403 dbSNP
rs1349609104 2406 dbSNP
rs1334087306 2408 dbSNP
rs145711900 2420 dbSNP
rs1030593633 2437 dbSNP
rs996317422 2441 dbSNP
rs1242180120 2442 dbSNP
rs770769287 2443 dbSNP
rs1238294632 2445 dbSNP
rs1345606431 2449 dbSNP
rs1302123209 2452 dbSNP
rs900690769 2453 dbSNP
rs1390252625 2456 dbSNP
rs538764635 2466 dbSNP
rs571292409 2473 dbSNP
rs546722675 2474 dbSNP
rs528771123 2480 dbSNP
rs1047889205 2492 dbSNP
rs1310908293 2497 dbSNP
rs949082941 2498 dbSNP
rs917793037 2507 dbSNP
rs1054977499 2509 dbSNP
rs1290117581 2511 dbSNP
rs1348399110 2524 dbSNP
rs1433452074 2534 dbSNP
rs937820893 2537 dbSNP
rs1394991290 2541 dbSNP
rs1279347608 2543 dbSNP
rs1444353652 2544 dbSNP
rs1174408376 2566 dbSNP
rs925139631 2571 dbSNP
rs149761613 2572 dbSNP
rs561382434 2573 dbSNP
rs1185034729 2587 dbSNP
rs968814499 2589 dbSNP
rs913320107 2593 dbSNP
rs139636351 2600 dbSNP
rs954748878 2601 dbSNP
rs1310669251 2608 dbSNP
rs577700175 2609 dbSNP
rs1374678929 2611 dbSNP
rs1410235527 2616 dbSNP
rs748982397 2621 dbSNP
rs777700624 2622 dbSNP
rs1219313537 2633 dbSNP
rs769639651 2634 dbSNP
rs531095703 2635 dbSNP
rs1441312878 2659 dbSNP
rs4818890 2661 dbSNP
rs1275571217 2662 dbSNP
rs1005970831 2682 dbSNP
rs1232424560 2689 dbSNP
rs1279858094 2695 dbSNP
rs1300492022 2716 dbSNP
rs372260223 2718 dbSNP
rs114265686 2720 dbSNP
rs1375378376 2728 dbSNP
rs577839131 2733 dbSNP
rs1200194430 2734 dbSNP
rs1047481633 2739 dbSNP
rs548712101 2740 dbSNP
rs1013641804 2741 dbSNP
rs896168698 2743 dbSNP
rs1054945702 2744 dbSNP
rs879257492 2769 dbSNP
rs1416263291 2773 dbSNP
rs144139963 2785 dbSNP
rs9976552 2786 dbSNP
rs573593108 2793 dbSNP
rs555327126 2802 dbSNP
rs1478300083 2826 dbSNP
rs1332959551 2827 dbSNP
rs555669376 2842 dbSNP
rs913278685 2843 dbSNP
rs1195660010 2852 dbSNP
rs1484531565 2854 dbSNP
rs1366208142 2856 dbSNP
rs1230813442 2858 dbSNP
rs1250045748 2865 dbSNP
rs1339104089 2866 dbSNP
rs988931922 2867 dbSNP
rs933301888 2870 dbSNP
rs537373724 2892 dbSNP
rs923328087 2895 dbSNP
rs1251767439 2900 dbSNP
rs1008537 2907 dbSNP
rs185417858 2908 dbSNP
rs1371171068 2911 dbSNP
rs750818189 2915 dbSNP
rs538743532 2916 dbSNP
rs1163575839 2930 dbSNP
rs1396641589 2936 dbSNP
rs192252855 2941 dbSNP
rs1231861093 2947 dbSNP
rs1459750796 2952 dbSNP
rs1355168155 2979 dbSNP
rs1285333028 2999 dbSNP
rs1325318137 3000 dbSNP
rs1389462895 3008 dbSNP
rs984921367 3018 dbSNP
rs35457610 3020 dbSNP
rs950924223 3023 dbSNP
rs553441526 3038 dbSNP
rs1293672494 3039 dbSNP
rs1013360125 3045 dbSNP
rs896126440 3049 dbSNP
rs534663681 3050 dbSNP
rs567669593 3051 dbSNP
rs903746932 3053 dbSNP
rs1162989266 3064 dbSNP
rs1043638262 3075 dbSNP
rs1474118042 3077 dbSNP
rs549374083 3086 dbSNP
rs892325802 3088 dbSNP
rs1053602366 3091 dbSNP
rs933456247 3094 dbSNP
rs1473768388 3095 dbSNP
rs923265393 3101 dbSNP
rs866034586 3108 dbSNP
rs1464934254 3112 dbSNP
rs111591365 3125 dbSNP
rs765553224 3133 dbSNP
rs1259263812 3134 dbSNP
rs943357258 3137 dbSNP
rs1457776540 3148 dbSNP
rs909433431 3169 dbSNP
rs1211390557 3171 dbSNP
rs985076151 3174 dbSNP
rs1333661547 3198 dbSNP
rs531264213 3209 dbSNP
rs570239065 3210 dbSNP
rs1419687181 3231 dbSNP
rs1474218630 3232 dbSNP
rs759937128 3233 dbSNP
rs1026512159 3240 dbSNP
rs1371893267 3254 dbSNP
rs992308999 3261 dbSNP
rs77638336 3285 dbSNP
rs1033398341 3290 dbSNP
rs533052165 3298 dbSNP
rs903547428 3314 dbSNP
rs1022152278 3328 dbSNP
rs1280847444 3329 dbSNP
rs1324176561 3343 dbSNP
rs367604413 3346 dbSNP
rs1461161864 3351 dbSNP
rs1336618665 3355 dbSNP
rs866911366 3361 dbSNP
rs1020589551 3367 dbSNP
rs1467629631 3370 dbSNP
rs112703534 3389 dbSNP
rs1331780236 3390 dbSNP
rs1405715431 3391 dbSNP
rs187368595 3394 dbSNP
rs559147198 3395 dbSNP
rs1258366769 3398 dbSNP
rs1200665043 3399 dbSNP
rs1485348903 3399 dbSNP
rs1259402494 3410 dbSNP
rs960224486 3410 dbSNP
rs1439806272 3411 dbSNP
rs1484554383 3415 dbSNP
rs1239505877 3421 dbSNP
rs1252488822 3422 dbSNP
rs57388751 3437 dbSNP
rs1009517303 3447 dbSNP
rs866847590 3451 dbSNP
rs60177620 3460 dbSNP
rs1246924593 3464 dbSNP
rs1175729799 3468 dbSNP
rs182712667 3476 dbSNP
rs1478485098 3478 dbSNP
rs1315443755 3479 dbSNP
rs1284211789 3482 dbSNP
rs1241462769 3484 dbSNP
rs1414580275 3494 dbSNP
rs190406482 3496 dbSNP
rs1050983800 3502 dbSNP
rs933820496 3509 dbSNP
rs901892782 3510 dbSNP
rs528855797 3522 dbSNP
rs561740539 3523 dbSNP
rs1039148655 3534 dbSNP
rs544772941 3542 dbSNP
rs1440252737 3544 dbSNP
rs770999743 3549 dbSNP
rs943324797 3551 dbSNP
rs909235794 3558 dbSNP
rs1304307652 3559 dbSNP
rs575959983 3566 dbSNP
rs1049764035 3567 dbSNP
rs1438373189 3576 dbSNP
rs929607964 3580 dbSNP
rs1282048902 3581 dbSNP
rs919416767 3592 dbSNP
rs1345241483 3605 dbSNP
rs4818889 3609 dbSNP
rs4818888 3610 dbSNP
rs34549906 3611 dbSNP
rs879356672 3611 dbSNP
rs1209893456 3617 dbSNP
rs1382082096 3624 dbSNP
rs571912766 3625 dbSNP
rs1481608191 3636 dbSNP
rs553164370 3640 dbSNP
rs1432024675 3641 dbSNP
rs1425449864 3650 dbSNP
rs1192525402 3651 dbSNP
rs535132836 3652 dbSNP
rs1262973231 3659 dbSNP
rs1434268514 3660 dbSNP
rs1217783440 3665 dbSNP
rs1489593316 3666 dbSNP
rs73907123 3671 dbSNP
rs1021997435 3677 dbSNP
rs1232634401 3685 dbSNP
rs73381370 3686 dbSNP
rs1298083721 3698 dbSNP
rs113233962 3701 dbSNP
rs550030950 3711 dbSNP
rs1029999594 3712 dbSNP
rs1304906011 3721 dbSNP
rs1297414781 3740 dbSNP
rs376463446 3760 dbSNP
rs116314744 3761 dbSNP
rs111727008 3764 dbSNP
rs1465129530 3769 dbSNP
rs1377662745 3777 dbSNP
rs1007676041 3789 dbSNP
rs887769367 3795 dbSNP
rs139344334 3802 dbSNP
rs566285455 3809 dbSNP
rs111887339 3810 dbSNP
rs73381368 3816 dbSNP
rs1057137224 3827 dbSNP
rs561506614 3829 dbSNP
rs199953102 3847 dbSNP
rs8129129 3847 dbSNP
rs8132250 3849 dbSNP
rs1483847061 3850 dbSNP
rs386819124 3850 dbSNP
rs1251158014 3862 dbSNP
rs980482446 3866 dbSNP
rs1454044716 3870 dbSNP
rs1189451286 3873 dbSNP
rs544643233 3876 dbSNP
rs1257883822 3880 dbSNP
rs967812659 3885 dbSNP
rs1202508627 3891 dbSNP
rs563992196 3892 dbSNP
rs112249759 3893 dbSNP
rs1279002576 3911 dbSNP
rs987789478 3912 dbSNP
rs1219025751 3913 dbSNP
rs956584792 3922 dbSNP
rs1291401217 3923 dbSNP
rs747831555 3924 dbSNP
rs572110239 3928 dbSNP
rs1402798948 3947 dbSNP
rs560326987 3953 dbSNP
rs1304140167 3954 dbSNP
rs541142289 3956 dbSNP
rs963858925 3961 dbSNP
rs1018154701 3964 dbSNP
rs1270385768 3966 dbSNP
rs4818887 3967 dbSNP
rs1170881118 3968 dbSNP
rs887821905 3975 dbSNP
rs1212624637 3978 dbSNP
rs555470050 3987 dbSNP
rs187978601 3988 dbSNP
rs993490760 3997 dbSNP
rs1237322101 3998 dbSNP
rs1258865847 4005 dbSNP
rs1335407801 4005 dbSNP
rs746558331 4007 dbSNP
rs1056705526 4008 dbSNP
rs1457329116 4023 dbSNP
rs779610478 4027 dbSNP
rs146241541 4030 dbSNP
rs1200717875 4037 dbSNP
rs1332920639 4053 dbSNP
rs11909192 4054 dbSNP
rs182970736 4055 dbSNP
rs914966647 4060 dbSNP
rs1341065259 4061 dbSNP
rs988311909 4065 dbSNP
rs1443961037 4094 dbSNP
rs1484976505 4096 dbSNP
rs1186308984 4102 dbSNP
rs1375461430 4106 dbSNP
rs934992747 4111 dbSNP
rs922287048 4117 dbSNP
rs976658100 4118 dbSNP
rs573751813 4119 dbSNP
rs963994738 4120 dbSNP
rs1163359894 4124 dbSNP
rs1018206073 4135 dbSNP
rs141204430 4141 dbSNP
rs1157500051 4150 dbSNP
rs952672040 4152 dbSNP
rs1027721124 4163 dbSNP
rs114287469 4164 dbSNP
rs1180566339 4165 dbSNP
rs1467357963 4169 dbSNP
rs1428149910 4179 dbSNP
rs1266941860 4182 dbSNP
rs897818463 4183 dbSNP
rs1355852954 4192 dbSNP
rs35635557 4194 dbSNP
rs1235103452 4206 dbSNP
rs8127380 4213 dbSNP
rs1003503369 4216 dbSNP
rs905420701 4218 dbSNP
rs1267178343 4222 dbSNP
rs1045301713 4223 dbSNP
rs8131653 4233 dbSNP
rs549467160 4243 dbSNP
rs1309424743 4244 dbSNP
rs377381249 4250 dbSNP
rs531179706 4254 dbSNP
rs1052175500 4264 dbSNP
rs935109455 4266 dbSNP
rs1224412500 4269 dbSNP
rs1286359934 4274 dbSNP
rs922290429 4286 dbSNP
rs976375292 4287 dbSNP
rs1258701937 4291 dbSNP
rs1387732480 4298 dbSNP
rs563754543 4305 dbSNP
rs911119181 4306 dbSNP
rs984063343 4317 dbSNP
rs1296707337 4321 dbSNP
rs952563799 4322 dbSNP
rs1186191581 4323 dbSNP
rs1257474859 4324 dbSNP
rs1025933534 4333 dbSNP
rs1158659137 4336 dbSNP
rs753426775 4345 dbSNP
rs962402199 4353 dbSNP
rs1160606349 4357 dbSNP
rs1035076445 4358 dbSNP
rs1157877175 4363 dbSNP
rs190727522 4383 dbSNP
rs1375891355 4393 dbSNP
rs757578128 4396 dbSNP
rs969376791 4402 dbSNP
rs373098384 4411 dbSNP
rs527609355 4412 dbSNP
rs8127114 4413 dbSNP
rs1214160385 4430 dbSNP
rs1487959225 4431 dbSNP
rs1281409833 4436 dbSNP
rs187473075 4441 dbSNP
rs1223476320 4445 dbSNP
rs750384285 4455 dbSNP
rs542045959 4464 dbSNP
rs1342198391 4465 dbSNP
rs10674662 4487 dbSNP
rs113394976 4487 dbSNP
rs144771587 4487 dbSNP
rs397715458 4487 dbSNP
rs1233573850 4489 dbSNP
rs900884549 4496 dbSNP
rs574557612 4505 dbSNP
rs1296800746 4514 dbSNP
rs562119796 4528 dbSNP
rs910920669 4531 dbSNP
rs1468136769 4536 dbSNP
rs1176077805 4561 dbSNP
rs543958864 4562 dbSNP
rs183643879 4564 dbSNP
rs931262496 4570 dbSNP
rs1395312428 4571 dbSNP
rs918515778 4572 dbSNP
rs1436132412 4577 dbSNP
rs972945343 4578 dbSNP
rs959915188 4581 dbSNP
rs1412864248 4592 dbSNP
rs565948094 4594 dbSNP
rs375318465 4595 dbSNP
rs879672530 4602 dbSNP
rs60959434 4603 dbSNP
rs1330781298 4606 dbSNP
rs539723470 4614 dbSNP
rs1023624272 4616 dbSNP
rs1011154123 4621 dbSNP
rs1477339549 4628 dbSNP
rs1263844885 4629 dbSNP
rs1218653815 4640 dbSNP
rs1440599556 4651 dbSNP
rs1304172220 4656 dbSNP
rs1441601454 4656 dbSNP
rs531381188 4656 dbSNP
rs1200522985 4657 dbSNP
rs1346770250 4659 dbSNP
rs1275845945 4660 dbSNP
rs1218426513 4661 dbSNP
rs572747480 4662 dbSNP
rs1031259176 4663 dbSNP
rs1446522622 4667 dbSNP
rs1340379490 4669 dbSNP
rs1197471234 4670 dbSNP
rs1253065802 4670 dbSNP
rs202113133 4670 dbSNP
rs75683418 4670 dbSNP
rs780171158 4670 dbSNP
rs1455359696 4672 dbSNP
rs554177353 4673 dbSNP
rs13050466 4675 dbSNP
rs1376902418 4683 dbSNP
rs113625623 4694 dbSNP
rs200641675 4695 dbSNP
rs1398394441 4706 dbSNP
rs1170178885 4716 dbSNP
rs1464936170 4717 dbSNP
rs1424124865 4722 dbSNP
rs1188024721 4723 dbSNP
rs1471804689 4728 dbSNP
rs901366092 4740 dbSNP
rs1040804737 4742 dbSNP
rs535996717 4754 dbSNP
rs368962705 4758 dbSNP
rs568582808 4776 dbSNP
rs549430458 4777 dbSNP
rs889453127 4785 dbSNP
rs1187649658 4787 dbSNP
rs143880211 4805 dbSNP
rs1255790157 4806 dbSNP
rs1396786961 4818 dbSNP
rs1439036376 4819 dbSNP
rs1197664996 4821 dbSNP
rs9981509 4822 dbSNP
rs931004973 4825 dbSNP
rs1226959670 4855 dbSNP
rs918472161 4856 dbSNP
rs1036971298 4863 dbSNP
rs190528657 4867 dbSNP
rs551800716 4868 dbSNP
rs1374710766 4891 dbSNP
rs1330727317 4903 dbSNP
rs1447861415 4905 dbSNP
rs928498806 4906 dbSNP
rs1172355896 4908 dbSNP
rs1403324715 4909 dbSNP
rs1413002699 4917 dbSNP
rs1230116000 4924 dbSNP
rs1268725366 4926 dbSNP
rs982150963 4930 dbSNP
rs969482850 4942 dbSNP
rs1446335076 4945 dbSNP
rs1235876453 4950 dbSNP
rs1177450975 4955 dbSNP
rs773462307 4956 dbSNP
rs568292731 4959 dbSNP
rs916666350 4965 dbSNP
rs989853221 4968 dbSNP
rs958076103 4984 dbSNP
rs1321446276 4987 dbSNP
rs1291260547 4991 dbSNP
rs1031646202 4993 dbSNP
rs1230571597 4995 dbSNP
rs1352121948 4996 dbSNP
rs149450023 4999 dbSNP
rs1240963371 5001 dbSNP
rs1379405053 5004 dbSNP
rs560356920 5007 dbSNP
rs548193539 5009 dbSNP
rs1007067185 5019 dbSNP
rs1211219641 5020 dbSNP
rs1323939203 5022 dbSNP
rs549995119 5027 dbSNP
rs1026751065 5043 dbSNP
rs995558501 5043 dbSNP
rs1378397056 5044 dbSNP
rs562691568 5049 dbSNP
rs1426113364 5050 dbSNP
rs1439711717 5051 dbSNP
rs1037342484 5052 dbSNP
rs543918248 5059 dbSNP
rs1487936896 5061 dbSNP
rs1247707134 5068 dbSNP
rs1225169565 5072 dbSNP
rs1167115866 5075 dbSNP
rs938632240 5083 dbSNP
rs186014003 5084 dbSNP
rs1285853923 5099 dbSNP
rs1044168705 5113 dbSNP
rs765124890 5114 dbSNP
rs774137876 5123 dbSNP
rs916621927 5126 dbSNP
rs1299509920 5132 dbSNP
rs564470408 5148 dbSNP
rs989596990 5148 dbSNP
rs761638528 5163 dbSNP
rs978747630 5172 dbSNP
rs1368553265 5173 dbSNP
rs5026185 5225 dbSNP
rs1406468948 5230 dbSNP
rs1358561064 5240 dbSNP
rs201326068 5242 dbSNP
rs985601097 5243 dbSNP
rs1297450535 5258 dbSNP
rs1419810009 5266 dbSNP
rs1346494259 5284 dbSNP
rs1173316086 5298 dbSNP
rs1345310001 5299 dbSNP
rs1276213278 5300 dbSNP
rs954213702 5303 dbSNP
rs1202049813 5312 dbSNP
rs1027134640 5315 dbSNP
rs1477014786 5319 dbSNP
rs1263135803 5320 dbSNP
rs1485287474 5321 dbSNP
rs35876086 5321 dbSNP
rs767429288 5321 dbSNP
rs995294201 5332 dbSNP
rs1487121699 5334 dbSNP
rs896805287 5341 dbSNP
rs572351948 5360 dbSNP
rs1209497174 5370 dbSNP
rs1015296047 5374 dbSNP
rs1002494941 5383 dbSNP
rs1265165851 5391 dbSNP
rs181540580 5393 dbSNP
rs146913668 5410 dbSNP
rs114494606 5415 dbSNP
rs368577880 5425 dbSNP
rs1277297961 5436 dbSNP
rs556364831 5440 dbSNP
rs111619886 5445 dbSNP
rs1054273150 5459 dbSNP
rs144086188 5462 dbSNP
rs924025077 5480 dbSNP
rs558377165 5487 dbSNP
rs1359397725 5488 dbSNP
rs533737738 5504 dbSNP
rs2298565 5521 dbSNP
rs944034661 5522 dbSNP
rs912797054 5523 dbSNP
rs138509356 5527 dbSNP
rs954178432 5529 dbSNP
rs920139019 5530 dbSNP
rs1423409891 5537 dbSNP
rs529978927 5540 dbSNP
rs1124085 5544 dbSNP
rs4051090 5557 dbSNP
rs796281866 5557 dbSNP
rs1181365027 5565 dbSNP
rs550841750 5571 dbSNP
rs529017079 5573 dbSNP
rs1197029519 5579 dbSNP
rs1317498084 5584 dbSNP
rs561857333 5585 dbSNP
rs147076478 5586 dbSNP
rs546002756 5587 dbSNP
rs1309192416 5615 dbSNP
rs1310421178 5621 dbSNP
rs892957896 5632 dbSNP
rs1394971872 5637 dbSNP
rs1379216301 5638 dbSNP
rs374941750 5639 dbSNP
rs1054257594 5649 dbSNP
rs999103299 5657 dbSNP
rs1444193439 5664 dbSNP
rs902570064 5678 dbSNP
rs1399085398 5684 dbSNP
rs749714412 5693 dbSNP
rs188654822 5694 dbSNP
rs944003700 5699 dbSNP
rs1367256775 5702 dbSNP
rs1048707 5705 dbSNP
rs564331246 5709 dbSNP
rs1049995365 5718 dbSNP
rs932955432 5721 dbSNP
rs151265806 5726 dbSNP
rs748747685 5730 dbSNP
rs574837723 5741 dbSNP
rs1176842670 5774 dbSNP
rs974232086 5778 dbSNP
rs1238951568 5788 dbSNP
rs186286474 5792 dbSNP
rs544356728 5793 dbSNP
rs77205503 5794 dbSNP
rs971023411 5795 dbSNP
rs1022625892 5812 dbSNP
rs1360046214 5822 dbSNP
rs113544491 5829 dbSNP
rs533669273 5850 dbSNP
rs1033356866 5856 dbSNP
rs566450917 5858 dbSNP
rs1375706694 5863 dbSNP
rs998678457 5864 dbSNP
rs2298564 5865 dbSNP
rs77072387 5868 dbSNP
rs180965798 5875 dbSNP
rs1458877907 5893 dbSNP
rs1387556424 5895 dbSNP
rs550904921 5896 dbSNP
rs758558904 5908 dbSNP
rs1048710 5909 dbSNP
rs1488327907 5916 dbSNP
rs778885434 5919 dbSNP
rs1215747227 5924 dbSNP
rs1049716256 5934 dbSNP
rs8132808 5939 dbSNP
rs753640445 5941 dbSNP
rs1328120822 5942 dbSNP
rs1299174966 5945 dbSNP
rs765948197 5950 dbSNP
rs1394858987 5951 dbSNP
rs1327704211 5953 dbSNP
rs1463714296 5966 dbSNP
rs1399148230 5968 dbSNP
rs920160533 5980 dbSNP
rs765397058 5981 dbSNP
rs1476143335 5983 dbSNP
rs755751686 5984 dbSNP
rs1197295945 5995 dbSNP
rs1454249797 5998 dbSNP
rs1253965271 6003 dbSNP
rs1215991556 6009 dbSNP
rs1456584777 6018 dbSNP
rs1272644140 6021 dbSNP
rs1196440847 6024 dbSNP
rs1234195177 6028 dbSNP
rs552624100 6030 dbSNP
rs1254339427 6032 dbSNP
rs760268978 6036 dbSNP
rs940185040 6044 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000407780.3 | 3UTR | CACCCCGCUCUCCCCUCUCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
118 hsa-miR-3160-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066658 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT075318 SF3B3 splicing factor 3b subunit 3 2 4
MIRT077083 EIF1 eukaryotic translation initiation factor 1 2 2
MIRT100381 HSPA1B heat shock protein family A (Hsp70) member 1B 2 6
MIRT135259 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT184913 ZNF268 zinc finger protein 268 2 2
MIRT218862 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT446580 FPR2 formyl peptide receptor 2 2 2
MIRT448834 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT449455 RNF13 ring finger protein 13 2 2
MIRT452284 CARD8 caspase recruitment domain family member 8 2 2
MIRT452628 FAM162A family with sequence similarity 162 member A 2 2
MIRT453454 GLG1 golgi glycoprotein 1 2 2
MIRT454188 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 6
MIRT454434 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT454575 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT455555 TRAF1 TNF receptor associated factor 1 2 6
MIRT455841 MPL MPL proto-oncogene, thrombopoietin receptor 2 6
MIRT455969 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT456805 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457320 DUSP19 dual specificity phosphatase 19 2 2
MIRT457366 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457684 ZNF587 zinc finger protein 587 2 2
MIRT458158 LYRM4 LYR motif containing 4 2 6
MIRT458641 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT459134 FADS6 fatty acid desaturase 6 2 2
MIRT459153 NARF nuclear prelamin A recognition factor 2 4
MIRT460460 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460974 STK17B serine/threonine kinase 17b 2 2
MIRT461439 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT461507 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2 2
MIRT462490 GSR glutathione-disulfide reductase 2 2
MIRT462638 PHF5A PHD finger protein 5A 2 2
MIRT463279 ZFX zinc finger protein, X-linked 2 2
MIRT463360 ZFAND4 zinc finger AN1-type containing 4 2 2
MIRT465777 TMOD3 tropomodulin 3 2 2
MIRT466143 TMEM120B transmembrane protein 120B 2 2
MIRT468401 SETD3 SET domain containing 3 2 2
MIRT468998 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT471574 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT472108 NME2 NME/NM23 nucleoside diphosphate kinase 2 2 2
MIRT472125 NME1-NME2 NME1-NME2 readthrough 2 2
MIRT473020 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT473083 MORN4 MORN repeat containing 4 2 2
MIRT475598 HMGB2 high mobility group box 2 2 4
MIRT475937 GXYLT2 glucoside xylosyltransferase 2 2 8
MIRT476117 GPR157 G protein-coupled receptor 157 2 2
MIRT476406 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT478003 DNAL1 dynein axonemal light chain 1 2 2
MIRT487969 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489418 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491522 IL10RA interleukin 10 receptor subunit alpha 2 2
MIRT492673 PLEC plectin 2 2
MIRT493545 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT513085 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT514009 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT516683 ZNF860 zinc finger protein 860 2 2
MIRT518392 ZNF250 zinc finger protein 250 2 2
MIRT522683 LUZP1 leucine zipper protein 1 2 6
MIRT524488 CEP97 centrosomal protein 97 2 2
MIRT527457 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT527705 IL17REL interleukin 17 receptor E like 2 2
MIRT531647 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT532381 UMPS uridine monophosphate synthetase 2 2
MIRT532588 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT533555 TPM4 tropomyosin 4 2 2
MIRT548371 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT550250 PVR poliovirus receptor 2 2
MIRT552555 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554113 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT554131 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT561344 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT561638 RUNX3 runt related transcription factor 3 2 2
MIRT566497 PBX2P1 PBX homeobox 2 pseudogene 1 2 2
MIRT570583 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572731 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT574041 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT575231 Fut1 fucosyltransferase 1 2 2
MIRT606811 BICD2 BICD cargo adaptor 2 2 2
MIRT621016 CLSTN3 calsyntenin 3 2 2
MIRT637852 PDCL3 phosducin like 3 2 2
MIRT640477 ZNF557 zinc finger protein 557 2 2
MIRT642827 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT643887 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT664874 PCNXL2 pecanex homolog 2 2 2
MIRT680528 PRIM2 DNA primase subunit 2 2 2
MIRT680648 KIAA1456 KIAA1456 2 2
MIRT680807 ZNF578 zinc finger protein 578 2 2
MIRT680921 STX2 syntaxin 2 2 2
MIRT681112 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT681147 INTS7 integrator complex subunit 7 2 2
MIRT681966 TFCP2 transcription factor CP2 2 2
MIRT684316 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT684906 GSG2 histone H3 associated protein kinase 2 2
MIRT685499 MED16 mediator complex subunit 16 2 2
MIRT685929 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686875 SLC25A32 solute carrier family 25 member 32 2 2
MIRT688204 FNIP1 folliculin interacting protein 1 2 2
MIRT688791 CCNB1 cyclin B1 2 2
MIRT689227 RPS19 ribosomal protein S19 2 2
MIRT690470 ZNF33A zinc finger protein 33A 2 2
MIRT691982 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT694006 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT694529 TRIM72 tripartite motif containing 72 2 2
MIRT695420 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT695784 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT697799 UBXN2A UBX domain protein 2A 2 2
MIRT698275 TMEM2 transmembrane protein 2 2 2
MIRT698317 TMEM136 transmembrane protein 136 2 2
MIRT699971 RREB1 ras responsive element binding protein 1 2 2
MIRT700717 PNO1 partner of NOB1 homolog 2 2
MIRT701721 MTMR12 myotubularin related protein 12 2 2
MIRT701879 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT702959 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT706178 ZNF716 zinc finger protein 716 2 2
MIRT706463 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT718154 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT718711 ANKRD18A ankyrin repeat domain 18A 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3160-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3160-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-3160-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3160-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission