pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DUSP9   
Synonyms MKP-4, MKP4
Description dual specificity phosphatase 9
Transcript NM_001395   
Expression
Putative miRNA Targets on DUSP9
3'UTR of DUSP9
(miRNA target sites are highlighted)
>DUSP9|NM_001395|3'UTR
   1 GGCCCCGTGGCCGGCAGGCCGGCCCCTGCCCCACCCCCACCCACGGGTGTCCCTGCCCACTCGTGTGGCAAGGGAGGGGA
  81 GGGCAGGAGGGCTCGGCCTGAGCAGGGTGCTGGGGGGAGAGCGCAATACCTCACGCGGGCTGCCGTCCTAATCAACGTGC
 161 CTATGGCGGGACCACGCTCGGAGCCTGCCTCTTCTGCGACTGTTACTTTTTCTTTGCGGGATGGGGGTGGGGGTTCCCTC
 241 TCCAGGTGGTTGTCCAGGCCCAGGTCCCGGCCCTGGGTGCTCAGCCAGCTCGGCTAGGCCCTGCGCCTCCCTGCGCTTCC
 321 CCCTTCAGGAAGGGTGTGTGCCACCTCGTTGCACTGGATCCCAGTGGCTGCTTGGGGGAGAGGCGTTTGCCATCACTGGT
 401 GTTGTCACCTCCCTGTTTCTCCACCAAGGGCTTGGGCCTCTCGGGGCTGGGGCCTCCCAGGGGATGGGGACCCAGAGTGC
 481 AGTGGCCGCCCACATCCATGGCCTAGGAGCTACTGGGCAGGTTCCCGGCCACACATCTGGTGGGCTGTTTTGTTTTTTTT
 561 TTTTCCTCTTCCCCCAGATGTCTTGACGGGATCACTGGGGCTCTTTGTGAGTGAGGGTGGCCAAACTACCGCCGGAGGAG
 641 ATGGGGTCTCAGAGCGAGAGCTGCGGAGGGGGAGGGGAAGAAGAAGGCCTCACTTTTGCTGCTGCGGGGCCCACACAGCC
 721 GCTGCTACTTTGGGGGGTGGGGAAGGGGCCAAGCTGCAGACACACACAGTCATTCATTTCTGTCCACACCCCTGTGGGTG
 801 GCGGGTGTGCGTGTGTGTGCTTGTGTGTGCGCACGTGTCGGCGCTCACACACACATGCTAGCCCACTGATGCACCCAGCC
 881 CAGGGCTGGCAGTCTTTGCAGCGTGGGGCCGTCTCACCCTGGAGCCTGGAGAGGATCTATGCTTGTTTGTTTTTGTAATC
 961 CATATCATAGTTGCTTTCTTTAATTGTTCCTTCTGAATAAACAGTTTATTTAAGATACTGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gggguGGAAA--AGAAGGGGg 5'
               ::|||  |||||||| 
Target 5' tttttTTTTTCCTCTTCCCCc 3'
555 - 575 152.00 -17.30
2
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |: |||   ||||||| 
Target 5' gcCTCCCTGCGCTTCCCCc 3'
305 - 323 149.00 -27.40
3
miRNA  3' ggGGUGGA--AAAGAAGGGGg 5'
            :|||||   | :|||:|| 
Target 5' tgTCACCTCCCTGTTTCTCCa 3'
403 - 423 123.00 -19.10
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs782521716 4 dbSNP
rs782653092 7 dbSNP
rs782234452 8 dbSNP
rs1408160104 9 dbSNP
rs570349306 13 dbSNP
rs782338310 14 dbSNP
rs782430274 15 dbSNP
rs782021024 21 dbSNP
rs782266921 22 dbSNP
rs951428660 30 dbSNP
rs1381337800 34 dbSNP
rs782371278 38 dbSNP
rs781974400 41 dbSNP
rs368890333 45 dbSNP
rs1239769015 49 dbSNP
rs1211421613 53 dbSNP
rs1441405690 56 dbSNP
rs983261087 63 dbSNP
rs909988774 66 dbSNP
rs1218356612 89 dbSNP
rs963199378 92 dbSNP
rs1353914401 95 dbSNP
rs975640081 96 dbSNP
rs1381044940 100 dbSNP
rs921438479 106 dbSNP
rs934191159 111 dbSNP
rs1447198523 115 dbSNP
rs1339954525 117 dbSNP
rs1051363909 118 dbSNP
rs1361453081 120 dbSNP
rs1158248508 122 dbSNP
rs1418317618 124 dbSNP
rs1416405300 135 dbSNP
rs911531459 136 dbSNP
rs1472724050 137 dbSNP
rs1235266662 138 dbSNP
rs1488315073 143 dbSNP
rs1284931968 145 dbSNP
rs1213992379 146 dbSNP
rs935040468 149 dbSNP
rs1052612084 150 dbSNP
rs1323358462 154 dbSNP
rs1290249098 158 dbSNP
rs1376832776 164 dbSNP
rs1279978613 168 dbSNP
rs781969131 169 dbSNP
rs1341194087 176 dbSNP
rs1297890452 177 dbSNP
rs1011082350 181 dbSNP
rs1351998221 191 dbSNP
rs1165868815 199 dbSNP
rs1044839068 200 dbSNP
rs1412318403 203 dbSNP
rs782104787 207 dbSNP
rs905055531 218 dbSNP
rs1477896954 223 dbSNP
rs1003388589 224 dbSNP
rs782773648 228 dbSNP
rs951442522 234 dbSNP
rs1220600802 237 dbSNP
rs1004254132 259 dbSNP
rs6643635 264 dbSNP
rs1319674799 269 dbSNP
rs1259979450 270 dbSNP
rs146844151 271 dbSNP
rs192098207 281 dbSNP
rs1277582437 282 dbSNP
rs368480852 292 dbSNP
rs1213051509 293 dbSNP
rs921408955 296 dbSNP
rs1369952267 300 dbSNP
rs1294310568 302 dbSNP
rs781826244 305 dbSNP
rs1392723548 306 dbSNP
rs782504970 309 dbSNP
rs1466542460 313 dbSNP
rs924912477 316 dbSNP
rs934983644 323 dbSNP
rs1434363235 327 dbSNP
rs1425486861 330 dbSNP
rs1190255289 338 dbSNP
rs1487420383 339 dbSNP
rs1052073882 345 dbSNP
rs914895280 349 dbSNP
rs201205318 352 dbSNP
rs200991622 353 dbSNP
rs868940507 356 dbSNP
rs868996144 360 dbSNP
rs370313865 363 dbSNP
rs868907297 363 dbSNP
rs781873142 364 dbSNP
rs1311894662 386 dbSNP
rs782529526 400 dbSNP
rs372383980 401 dbSNP
rs1003357550 413 dbSNP
rs1359172661 431 dbSNP
rs1174999690 434 dbSNP
rs1452172787 443 dbSNP
rs1381994992 444 dbSNP
rs1178988628 459 dbSNP
rs1438808161 461 dbSNP
rs1236309517 462 dbSNP
rs1202051659 464 dbSNP
rs782187147 465 dbSNP
rs1484278787 466 dbSNP
rs1256656127 474 dbSNP
rs11407625 477 dbSNP
rs138537391 477 dbSNP
rs868929976 479 dbSNP
rs1056304916 488 dbSNP
rs1288383970 489 dbSNP
rs1241361510 495 dbSNP
rs1376555860 501 dbSNP
rs782598436 526 dbSNP
rs1305501695 528 dbSNP
rs887061916 531 dbSNP
rs1379337383 534 dbSNP
rs1301730144 538 dbSNP
rs1362099995 546 dbSNP
rs1432522022 546 dbSNP
rs1158824097 553 dbSNP
rs1361778118 553 dbSNP
rs376150077 553 dbSNP
rs782224597 553 dbSNP
rs1424310796 554 dbSNP
rs184700190 554 dbSNP
rs1257006993 556 dbSNP
rs1181318257 558 dbSNP
rs1265635214 559 dbSNP
rs1217539972 560 dbSNP
rs1353524860 565 dbSNP
rs1259321558 571 dbSNP
rs1247689525 575 dbSNP
rs1322817498 584 dbSNP
rs1312583267 589 dbSNP
rs1412409024 591 dbSNP
rs1341770241 596 dbSNP
rs1298435086 614 dbSNP
rs1399002109 622 dbSNP
rs1382583745 632 dbSNP
rs1164754770 633 dbSNP
rs1458378934 635 dbSNP
rs1367846436 645 dbSNP
rs1162635738 647 dbSNP
rs1474271511 651 dbSNP
rs868987218 656 dbSNP
rs1016895411 659 dbSNP
rs1260136311 661 dbSNP
rs1212040222 665 dbSNP
rs898508309 666 dbSNP
rs1265384329 667 dbSNP
rs868909330 669 dbSNP
rs1319467199 670 dbSNP
rs1278260358 673 dbSNP
rs1217689247 678 dbSNP
rs1324284152 687 dbSNP
rs1028439332 688 dbSNP
rs1387154460 693 dbSNP
rs1389668213 694 dbSNP
rs955505549 697 dbSNP
rs1425933592 699 dbSNP
rs189051505 706 dbSNP
rs1475102723 707 dbSNP
rs1201201635 710 dbSNP
rs1032265558 715 dbSNP
rs782137262 721 dbSNP
rs782705384 732 dbSNP
rs956278736 734 dbSNP
rs990826357 737 dbSNP
rs1336819068 738 dbSNP
rs914885893 741 dbSNP
rs946416073 743 dbSNP
rs1233519430 747 dbSNP
rs1330363913 761 dbSNP
rs1300956620 766 dbSNP
rs1448961533 767 dbSNP
rs1400982285 769 dbSNP
rs1330536253 786 dbSNP
rs193013838 790 dbSNP
rs1394342140 796 dbSNP
rs980472506 796 dbSNP
rs1174599347 797 dbSNP
rs185735700 803 dbSNP
rs1394903010 804 dbSNP
rs1192106499 805 dbSNP
rs1441883556 810 dbSNP
rs939178131 812 dbSNP
rs1181641249 826 dbSNP
rs377555506 831 dbSNP
rs1280113313 832 dbSNP
rs1200726706 835 dbSNP
rs782751533 836 dbSNP
rs1242080902 841 dbSNP
rs939927884 843 dbSNP
rs1308451995 844 dbSNP
rs1334116605 849 dbSNP
rs1336219414 862 dbSNP
rs1415295554 865 dbSNP
rs1375099140 873 dbSNP
rs1171952644 874 dbSNP
rs1421913712 884 dbSNP
rs1381314882 886 dbSNP
rs1158558354 904 dbSNP
rs1038705784 912 dbSNP
rs781862854 930 dbSNP
rs996874042 935 dbSNP
rs1187680511 950 dbSNP
rs1485030775 987 dbSNP
rs1254978576 988 dbSNP
rs1218256340 992 dbSNP
rs1354233662 994 dbSNP
rs1283276460 995 dbSNP
rs1222051256 997 dbSNP
rs1358337453 1003 dbSNP
rs189027193 1005 dbSNP
rs1028408118 1008 dbSNP
rs1284665518 1012 dbSNP
rs891183114 1019 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |: |||   ||||||| 
Target 5' -cCUCCCUGCGCUUCCCCc 3'
1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000370167.4 | 3UTR | CCUCCCUGCGCUUCCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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