miRTarBase - #MIRT494456


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pre-miRNA Information
pre-miRNA hsa-mir-4653   
Genomic Coordinates chr7: 101159473 - 101159555
Description Homo sapiens miR-4653 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4653-5p
Sequence 10| UCUCUGAGCAAGGCUUAACACC |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs566953516 2 dbSNP
rs1307365749 4 dbSNP
rs1226652366 6 dbSNP
rs1216592229 12 dbSNP
rs1283699546 15 dbSNP
rs934609749 20 dbSNP
rs1377199291 21 dbSNP
rs1282994534 22 dbSNP
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B8DF7B miR-4653 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol BTG2   
Synonyms APRO1, PC3, TIS21
Description BTG anti-proliferation factor 2
Transcript NM_006763   
Expression
Putative miRNA Targets on BTG2
3'UTR of BTG2
(miRNA target sites are highlighted)		 
>BTG2|NM_006763|3'UTR
   1 GCCCTTCCGCCCCCGCCCTGGGCGCCGCCGTGCTCATGCTGCCGTGACAACAGGCCACCACATACCTCAACCTGGGGAAC
  81 TGTATTTTTAAATGAAGAGCTATTTATATATATTATTTTTTTTTAAGAAAGGAGGAAAAGAAACCAAAAGTTTTTTTTAA
 161 GAAAAAAAATCCTTCAAGGGAGCTGCTTGGAAGTGGCCTCCCCAGGTGCCTTTGGAGAGAACTGTTGCGTGCTTGAGTCT
 241 GTGAGCCAGTGTCTGCCTATAGGAGGGGGAGCTGTTAGGGGGTAGACCTAGCCAAGGAGAAGTGGGAGACGTTTGGCTAG
 321 CACCCCAGGAAGATGTGAGAGGGAGCAAGCAAGGTTAGCAACTGTGAACAGAGAGGTCGGGATTTGCCCTGGGGGAGGAA
 401 GAGAGGCCAAGTTCAGAGCTCTCTGTCTCCCCCAGCCAGACACCTGCATCCCTGGCTCCTCTATTACTCAGGGGCATTCA
 481 TGCCTGGACTTAAACAATACTATGTTATCTTTTCTTTTATTTTTCTAATGAGGTCCTGGGCAGAGAGTGAAAAGGCCTCT
 561 CCTGATTCCTACTGTCCTAAGCTGCTTTTCTTGAAATCATGACTTGTTTCTAATTCTACCCTCAGGGGCCTGTAGATGTT
 641 GCTTTCCAGCCAGGAATCTAAAGCTTTGGGTTTTCTGAGGGGGGGGAGGAGGGAACTGGAGGTTATTGGGGTTAGGATGG
 721 AAGGGAACTCTGCACAAAACCTTTGCTTTGCTAGTGCTGCTTTGTGTGTATGTGTGGCAAATAATTTGGGGGTGATTTGC
 801 AATGAAATTTTGGGACCCAAAGAGTATCCACTGGGGATGTTTTTTGGCCAAAACTCTTCCTTTTGGAACCACATGAAAGT
 881 CTTGATGCTGCTGCCATGATCCCTTTGAGAGGTGGCTCAAAAGCTACAGGGAACTCCAGGTCCTTTATTACTGCCTTCTT
 961 TTCAAAAGCACAACTCTCCTCTAACCCTCCCCTCCCCCTTCCCTTCTGGTCGGGTCATAGAGCTACCGTATTTTCTAGGA
1041 CAAGAGTTCTCAGTCACTGTGCAATATGCCCCCTGGGTCCCAGGAGGGTCTGGAGGAAAACTGGCTATCAGAACCTCCTG
1121 ATGCCCTGGTGGGCTTAGGGAACCATCTCTCCTGCTCTCCTTGGGATGATGGCTGGCTAGTCAGCCTTGCATGTATTCCT
1201 TGGCTGAATGGGAGAGTGCCCCATGTTCTGCAAGACTACTTGGTATTCTTGTAGGGCCGACACTAAATAAAAGCCAAACC
1281 TTGGGCACTGTTTTTTCTCCCTGGTGCTCAGAGCACCTGTGGGAAAGGTTGCTGTCTGTCTCAGTACAATCCAAATTTGT
1361 CGTAGACTTGTGCAATATATACTGTTGTGGGTTGGAGAAAAGTGGAAAGCTACACTGGGAAGAAACTCCCTTCCTTCAAT
1441 TTCTCAGTGACATTGATGAGGGGTCCTCAAAAGACCTCGAGTTTCCCAAACCGAATCACCTTAAGAAGGACAGGGCTAGG
1521 GCATTTGGCCAGGATGGCCACCCTCCTGCTGTTGCCCCTTAGTGAGGAATCTTCACCCCACTTCCTCTACCCCCAGGTTC
1601 TCCTCCCCACAGCCAGTCCCCTTTCCTGGATTTCTAAACTGCTCAATTTTGACTCAAAGGTGCTATTTACCAAACACTCT
1681 CCCTACCCATTCCTGCCAGCTCTGCCTCCTTTTCAACTCTCCACATTTTGTATTGCCTTCCCAGACCTGCTTCCAGTCTT
1761 TATTGCTTTAAAGTTCACTTTGGGCCCACAGACCCAAGAGCTAATTTTCTGGTTTGTGGGTTGAAACAAAGCTGTGAATC
1841 ACTGCAGGCTGTGTTCTTGCATCTTGTCTGCAAACAGGTCCCTGCCTTTTTAGAAGCAGCCTCATGGTCTCATGCTTAAT
1921 CTTGTCTCTCTTCTCTTCTTTATGATGTTCACTTTAAAAACAACAAAACCCCTGAGCTGGACTGTTGAGCAGGCCTGTCT
2001 CTCCTATTAAGTAAAAATAAATAGTAGTAGTATGTTTGTAAGCTATTCTGACAGAAAAGACAAAGGTTACTAATTGTATG
2081 ATAGTGTTTTTATATGGAAGAATGTACAGCTTATGGACAAATGTACACCTTTTTGTTACTTTAATAAAAATGTAGTAGGA
2161 TAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccACAAUUCGGA--ACGAGUCUCu 5'
            | ||   |||  ||||||||| 
Target 5' ttTTTTCTCCCTGGTGCTCAGAGc 3'
 1291 - 1314 158.00 -16.20
2 
miRNA  3' ccacaaUUCGGAACGAGUCUCu 5'
                |:|||  |:|||||| 
Target 5' gaagagAGGCCAAGTTCAGAGc 3'
 398 - 419 144.00 -16.70
3 
miRNA  3' ccACA---AUUCGGA-ACGAGUCUCu 5'
            |||   ||| :||   |||||:| 
Target 5' ctTGTTTCTAATTCTACCCTCAGGGg 3'
 603 - 628 136.00 -11.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31521048 5 COSMIC
COSN30150327 14 COSMIC
COSN30529015 25 COSMIC
COSN30151598 27 COSMIC
COSN31505873 33 COSMIC
COSN30153261 69 COSMIC
COSN25480150 97 COSMIC
COSN25447161 101 COSMIC
COSN26504475 111 COSMIC
COSN31769502 112 COSMIC
COSN18724448 125 COSMIC
COSN31595827 178 COSMIC
COSN26504601 190 COSMIC
COSN31769503 344 COSMIC
COSN31543119 515 COSMIC
COSN9057026 527 COSMIC
COSN24520822 672 COSMIC
COSN20095823 687 COSMIC
COSN21469439 717 COSMIC
COSN26585385 733 COSMIC
COSN28363909 846 COSMIC
COSN21538062 863 COSMIC
COSN19405058 959 COSMIC
COSN31769505 1024 COSMIC
COSN31541478 1069 COSMIC
COSN26249695 1114 COSMIC
COSN18723901 1139 COSMIC
COSN31769506 1229 COSMIC
COSN30538366 1281 COSMIC
COSN31514034 1362 COSMIC
COSN31960380 1363 COSMIC
COSN31542781 1444 COSMIC
COSN31556057 1528 COSMIC
COSN31514401 1616 COSMIC
COSN1427020 1987 COSMIC
COSN17183007 2003 COSMIC
COSN31522292 2017 COSMIC
COSN22877916 2031 COSMIC
COSN28742730 2051 COSMIC
COSN28742953 2055 COSMIC
COSN30545449 2083 COSMIC
COSN25648869 2157 COSMIC
rs538260231 840 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1342422747 1 dbSNP
rs1415494436 3 dbSNP
rs1292812622 8 dbSNP
rs369785815 9 dbSNP
rs769970472 9 dbSNP
rs1208400964 10 dbSNP
rs756195828 10 dbSNP
rs766409214 11 dbSNP
rs755200538 12 dbSNP
rs1252949151 14 dbSNP
rs201462115 15 dbSNP
rs778326561 16 dbSNP
rs747522944 17 dbSNP
rs1486481294 18 dbSNP
rs770448408 19 dbSNP
rs776081022 23 dbSNP
rs745407928 27 dbSNP
rs1173193600 28 dbSNP
rs543409078 30 dbSNP
rs1461802405 31 dbSNP
rs762803619 33 dbSNP
rs763854059 36 dbSNP
rs936449734 37 dbSNP
rs774313207 42 dbSNP
rs767547740 44 dbSNP
rs563817102 45 dbSNP
rs755110487 46 dbSNP
rs773541040 47 dbSNP
rs765548346 52 dbSNP
rs906436597 55 dbSNP
rs1199712110 59 dbSNP
rs1247926585 67 dbSNP
rs532470883 71 dbSNP
rs933030925 78 dbSNP
rs1051849698 82 dbSNP
rs140561243 86 dbSNP
rs1457094179 87 dbSNP
rs565056217 93 dbSNP
rs1176380139 95 dbSNP
rs963203697 105 dbSNP
rs1004884523 108 dbSNP
rs569803446 115 dbSNP
rs762792320 116 dbSNP
rs954227723 116 dbSNP
rs985410906 116 dbSNP
rs912533319 121 dbSNP
rs1162613918 125 dbSNP
rs1413585176 136 dbSNP
rs965616805 145 dbSNP
rs1175971162 151 dbSNP
rs1454970746 151 dbSNP
rs1411600226 152 dbSNP
rs1476640311 162 dbSNP
rs978272725 162 dbSNP
rs145883516 165 dbSNP
rs936847166 169 dbSNP
rs1440961715 171 dbSNP
rs1399264379 174 dbSNP
rs1053984478 179 dbSNP
rs1348328691 181 dbSNP
rs1296526375 182 dbSNP
rs916313721 186 dbSNP
rs547719210 188 dbSNP
rs1444862686 194 dbSNP
rs1363940035 196 dbSNP
rs1336331419 201 dbSNP
rs898672572 208 dbSNP
rs947729519 214 dbSNP
rs1373298742 225 dbSNP
rs1046110576 228 dbSNP
rs995631283 229 dbSNP
rs1033761366 230 dbSNP
rs758798143 246 dbSNP
rs1004806296 247 dbSNP
rs959428702 261 dbSNP
rs1342974852 262 dbSNP
rs1036248225 269 dbSNP
rs1420823240 275 dbSNP
rs1013646072 279 dbSNP
rs1025406868 280 dbSNP
rs1259624705 312 dbSNP
rs994680486 313 dbSNP
rs1027510113 318 dbSNP
rs966699402 322 dbSNP
rs978416154 323 dbSNP
rs1202139199 325 dbSNP
rs1032258304 331 dbSNP
rs1309235641 336 dbSNP
rs954117248 342 dbSNP
rs1227308001 345 dbSNP
rs1006904171 349 dbSNP
rs1294529446 350 dbSNP
rs1415039233 370 dbSNP
rs957890041 372 dbSNP
rs1193720570 379 dbSNP
rs1444801008 380 dbSNP
rs1355701317 385 dbSNP
rs764489531 386 dbSNP
rs965313920 393 dbSNP
rs921705144 398 dbSNP
rs1420145246 399 dbSNP
rs776568889 404 dbSNP
rs933084594 415 dbSNP
rs567527162 422 dbSNP
rs12063729 433 dbSNP
rs907540815 434 dbSNP
rs1175323760 438 dbSNP
rs1478797289 441 dbSNP
rs1481490113 456 dbSNP
rs924214392 462 dbSNP
rs757491327 464 dbSNP
rs549485940 467 dbSNP
rs1274536514 468 dbSNP
rs1233343089 479 dbSNP
rs781339681 480 dbSNP
rs989650667 483 dbSNP
rs12085417 488 dbSNP
rs898744550 489 dbSNP
rs1374525331 500 dbSNP
rs1293254474 509 dbSNP
rs1403237512 520 dbSNP
rs931502952 520 dbSNP
rs1414087234 529 dbSNP
rs1326719417 533 dbSNP
rs538341532 541 dbSNP
rs1161560915 543 dbSNP
rs927622295 556 dbSNP
rs1408464372 557 dbSNP
rs1190368386 560 dbSNP
rs1467112679 561 dbSNP
rs1362524690 573 dbSNP
rs1213848868 574 dbSNP
rs1401156879 576 dbSNP
rs1258373861 578 dbSNP
rs375702332 580 dbSNP
rs1036729864 582 dbSNP
rs1317100154 583 dbSNP
rs1338934969 586 dbSNP
rs895285769 594 dbSNP
rs756202846 600 dbSNP
rs1014091948 601 dbSNP
rs138492634 603 dbSNP
rs1345362987 604 dbSNP
rs1382893444 617 dbSNP
rs902551369 621 dbSNP
rs1290654666 624 dbSNP
rs1006935143 637 dbSNP
rs888907302 637 dbSNP
rs572300436 643 dbSNP
rs1452338551 645 dbSNP
rs1488947959 647 dbSNP
rs778779331 652 dbSNP
rs1217290640 661 dbSNP
rs1427800104 666 dbSNP
rs1259095055 669 dbSNP
rs1206353731 673 dbSNP
rs202052540 678 dbSNP
rs957924099 678 dbSNP
rs1255035741 679 dbSNP
rs373717932 679 dbSNP
rs397736594 679 dbSNP
rs573875025 679 dbSNP
rs5780160 679 dbSNP
rs761729330 679 dbSNP
rs766982614 679 dbSNP
rs1491142379 680 dbSNP
rs56048832 680 dbSNP
rs1382823313 681 dbSNP
rs373538301 681 dbSNP
rs974635442 681 dbSNP
rs1491495525 682 dbSNP
rs3795582 682 dbSNP
rs114151974 683 dbSNP
rs1194770520 684 dbSNP
rs1377981147 685 dbSNP
rs1185363200 686 dbSNP
rs200299376 687 dbSNP
rs78869403 688 dbSNP
rs554848532 689 dbSNP
rs1281527839 702 dbSNP
rs1477855717 707 dbSNP
rs1195557237 719 dbSNP
rs990116670 724 dbSNP
rs907617206 726 dbSNP
rs1253594206 728 dbSNP
rs567587943 734 dbSNP
rs1023812316 745 dbSNP
rs752497704 747 dbSNP
rs574754503 752 dbSNP
rs1420339586 766 dbSNP
rs1297635051 771 dbSNP
rs113918784 781 dbSNP
rs367900254 782 dbSNP
rs1359232067 785 dbSNP
rs973031183 793 dbSNP
rs1416893655 800 dbSNP
rs543820952 810 dbSNP
rs1356307587 813 dbSNP
rs1313315239 826 dbSNP
rs1340452648 840 dbSNP
rs538260231 840 dbSNP
rs1394327930 842 dbSNP
rs931576651 854 dbSNP
rs1330830373 869 dbSNP
rs940363937 880 dbSNP
rs187962637 881 dbSNP
rs545970390 887 dbSNP
rs971745609 889 dbSNP
rs1162123158 897 dbSNP
rs771948296 909 dbSNP
rs1232088075 910 dbSNP
rs920227831 912 dbSNP
rs1181611565 917 dbSNP
rs1300759292 924 dbSNP
rs1436437516 926 dbSNP
rs930578614 927 dbSNP
rs1055268117 928 dbSNP
rs1355252536 929 dbSNP
rs1050734473 943 dbSNP
rs888980781 948 dbSNP
rs1235193012 952 dbSNP
rs1240299840 954 dbSNP
rs1335806105 955 dbSNP
rs944538045 957 dbSNP
rs1284643147 975 dbSNP
rs895305020 976 dbSNP
rs949576195 979 dbSNP
rs866232134 980 dbSNP
rs76519638 982 dbSNP
rs901252679 987 dbSNP
rs1391925783 990 dbSNP
rs1323365327 991 dbSNP
rs1046951321 994 dbSNP
rs1417870753 999 dbSNP
rs1157651073 1002 dbSNP
rs866825510 1003 dbSNP
rs141109235 1005 dbSNP
rs1365946027 1009 dbSNP
rs1211551500 1011 dbSNP
rs527493467 1012 dbSNP
rs547581235 1013 dbSNP
rs1215708551 1030 dbSNP
rs1468967361 1046 dbSNP
rs893760446 1049 dbSNP
rs1450755806 1050 dbSNP
rs1192018006 1051 dbSNP
rs1353060644 1059 dbSNP
rs1281110570 1061 dbSNP
rs1011165573 1062 dbSNP
rs372059695 1073 dbSNP
rs561189406 1082 dbSNP
rs868624412 1091 dbSNP
rs1032362748 1095 dbSNP
rs893784024 1096 dbSNP
rs1442941508 1097 dbSNP
rs1158196119 1107 dbSNP
rs1394611879 1108 dbSNP
rs1316971359 1115 dbSNP
rs1398635080 1124 dbSNP
rs1386661423 1125 dbSNP
rs1159570530 1127 dbSNP
rs1454106010 1128 dbSNP
rs746844675 1134 dbSNP
rs1196065370 1137 dbSNP
rs529927417 1140 dbSNP
rs556563281 1141 dbSNP
rs954744107 1144 dbSNP
rs756143754 1146 dbSNP
rs969586109 1146 dbSNP
rs1385407406 1155 dbSNP
rs1333757543 1163 dbSNP
rs191529784 1166 dbSNP
rs1285200870 1177 dbSNP
rs16851280 1178 dbSNP
rs1346902406 1181 dbSNP
rs1447052069 1187 dbSNP
rs1034798235 1192 dbSNP
rs1236446426 1194 dbSNP
rs1368175842 1199 dbSNP
rs1307966125 1200 dbSNP
rs1314552842 1203 dbSNP
rs374313138 1209 dbSNP
rs11586635 1212 dbSNP
rs961837311 1225 dbSNP
rs1327904585 1226 dbSNP
rs973096507 1232 dbSNP
rs920279956 1233 dbSNP
rs879162712 1240 dbSNP
rs1175874302 1244 dbSNP
rs989693507 1251 dbSNP
rs1419398419 1252 dbSNP
rs565394831 1259 dbSNP
rs1476429420 1260 dbSNP
rs910451465 1263 dbSNP
rs1187531171 1267 dbSNP
rs1239774023 1275 dbSNP
rs1458428748 1281 dbSNP
rs764873286 1288 dbSNP
rs1178198891 1297 dbSNP
rs534900693 1308 dbSNP
rs60342861 1310 dbSNP
rs916830474 1314 dbSNP
rs1212670162 1320 dbSNP
rs1340875696 1327 dbSNP
rs1166142148 1329 dbSNP
rs1278220051 1331 dbSNP
rs538887336 1332 dbSNP
rs1353142674 1333 dbSNP
rs949610709 1335 dbSNP
rs373141560 1337 dbSNP
rs1173352752 1348 dbSNP
rs1401460490 1362 dbSNP
rs1046540553 1363 dbSNP
rs924082329 1380 dbSNP
rs924422721 1398 dbSNP
rs780900419 1399 dbSNP
rs1164264463 1400 dbSNP
rs935433642 1403 dbSNP
rs935417653 1404 dbSNP
rs1189891303 1406 dbSNP
rs1483458733 1422 dbSNP
rs1330187720 1429 dbSNP
rs893841088 1432 dbSNP
rs1370577976 1439 dbSNP
rs1397216438 1440 dbSNP
rs1439447292 1442 dbSNP
rs1258183729 1444 dbSNP
rs1232122716 1448 dbSNP
rs1332297469 1449 dbSNP
rs1312771332 1458 dbSNP
rs1228469632 1461 dbSNP
rs1011322751 1462 dbSNP
rs1296771709 1466 dbSNP
rs1045367507 1469 dbSNP
rs575103998 1471 dbSNP
rs1339874690 1474 dbSNP
rs1325375497 1475 dbSNP
rs367892990 1479 dbSNP
rs905432979 1487 dbSNP
rs150236063 1493 dbSNP
rs763532512 1494 dbSNP
rs1407016424 1500 dbSNP
rs1175230744 1506 dbSNP
rs537329168 1509 dbSNP
rs1035206494 1515 dbSNP
rs745825418 1516 dbSNP
rs993294068 1521 dbSNP
rs1466752168 1533 dbSNP
rs557364252 1543 dbSNP
rs1274440494 1546 dbSNP
rs1213773374 1552 dbSNP
rs764567961 1553 dbSNP
rs577164404 1555 dbSNP
rs1303325329 1561 dbSNP
rs1255549733 1578 dbSNP
rs1396815564 1579 dbSNP
rs751564630 1580 dbSNP
rs572194545 1586 dbSNP
rs1009172053 1588 dbSNP
rs1196394152 1593 dbSNP
rs1014771219 1598 dbSNP
rs751952792 1603 dbSNP
rs78959463 1605 dbSNP
rs961818211 1609 dbSNP
rs994546782 1612 dbSNP
rs965952000 1620 dbSNP
rs1477675831 1622 dbSNP
rs796923660 1623 dbSNP
rs924477815 1627 dbSNP
rs1452443977 1655 dbSNP
rs958398989 1656 dbSNP
rs1254381834 1661 dbSNP
rs138699312 1670 dbSNP
rs1197667329 1672 dbSNP
rs866592912 1678 dbSNP
rs916839540 1679 dbSNP
rs1302980947 1683 dbSNP
rs915295201 1684 dbSNP
rs546139031 1686 dbSNP
rs771868400 1696 dbSNP
rs982744230 1709 dbSNP
rs762091614 1718 dbSNP
rs34345774 1721 dbSNP
rs1045104382 1724 dbSNP
rs1302123747 1725 dbSNP
rs1381703378 1731 dbSNP
rs905172671 1732 dbSNP
rs1412865713 1742 dbSNP
rs924142453 1754 dbSNP
rs1003803880 1755 dbSNP
rs1360955063 1756 dbSNP
rs1056722020 1764 dbSNP
rs1432841192 1765 dbSNP
rs1379285094 1771 dbSNP
rs1176239506 1775 dbSNP
rs1340922361 1777 dbSNP
rs935447347 1779 dbSNP
rs74137610 1780 dbSNP
rs1258991917 1789 dbSNP
rs34050060 1793 dbSNP
rs915323112 1813 dbSNP
rs1195429330 1820 dbSNP
rs1804736 1827 dbSNP
rs994052335 1837 dbSNP
rs1257304172 1847 dbSNP
rs1209146587 1848 dbSNP
rs1027434552 1860 dbSNP
rs1293141846 1865 dbSNP
rs951899429 1877 dbSNP
rs1227253490 1878 dbSNP
rs1007239467 1898 dbSNP
rs932000782 1899 dbSNP
rs1050432580 1902 dbSNP
rs1312114494 1903 dbSNP
rs915452021 1905 dbSNP
rs1804735 1906 dbSNP
rs1804737 1910 dbSNP
rs76416255 1919 dbSNP
rs1303374688 1943 dbSNP
rs1036647023 1944 dbSNP
rs1370877624 1956 dbSNP
rs965650259 1957 dbSNP
rs1484693145 1973 dbSNP
rs1416695775 1978 dbSNP
rs117103442 1991 dbSNP
rs138896134 1994 dbSNP
rs750671916 1995 dbSNP
rs1195753538 2007 dbSNP
rs1488236757 2020 dbSNP
rs1027389725 2022 dbSNP
rs879123876 2022 dbSNP
rs1334526222 2028 dbSNP
rs955923031 2028 dbSNP
rs1291675011 2029 dbSNP
rs1185214618 2031 dbSNP
rs990378187 2031 dbSNP
rs1427684462 2034 dbSNP
rs1313116199 2035 dbSNP
rs1804734 2041 dbSNP
rs561049519 2045 dbSNP
rs1130691 2049 dbSNP
rs1013057121 2055 dbSNP
rs1394216968 2059 dbSNP
rs567153308 2059 dbSNP
rs1023988259 2060 dbSNP
rs971436989 2070 dbSNP
rs756366363 2076 dbSNP
rs1473545899 2081 dbSNP
rs780081453 2085 dbSNP
rs1369440413 2093 dbSNP
rs530047112 2096 dbSNP
rs1417914540 2105 dbSNP
rs1240568092 2106 dbSNP
rs1031668907 2115 dbSNP
rs1393991304 2119 dbSNP
rs956894363 2124 dbSNP
rs989637128 2127 dbSNP
rs1056739357 2129 dbSNP
rs915352873 2142 dbSNP
rs932074289 2151 dbSNP
rs986585315 2156 dbSNP
rs898056851 2158 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_006763 | 3UTR | AAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_006763 | 3UTR | AGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903827
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_9124
Location of target site NM_006763 | 3UTR | AGAGCACCUGUGGGAAAGGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903828
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_9124
Location of target site NM_006763 | 3UTR | AGAGCACCUGUGGGAAAGGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_006763 | 3UTR | CAUGUUCUGCAAGACUACUUGGUAUUCUUGUAGGGCCGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_006763 | 3UTR | AGACUACUUGGUAUUCUUGUAGGGCCGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_006763 | 3UTR | GUGCCCCAUGUUCUGCAAGACUACUUGGUAUUCUUGUAGGGCCGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_006763 | 3UTR | AAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_006763 | 3UTR | AAGACUACUUGGUAUUCUUGUAGGGCCGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_006763 | 3UTR | CGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUGUGGGAAAGGUUGCUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000290551.4 | 3UTR | UAUUCUUGUAGGGCCGACACUAAAUAAAAGCCAAACCUUGGGCACUGUUUUUUCUCCCUGGUGCUCAGAGCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
78 hsa-miR-4653-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118186 ZNF544 zinc finger protein 544 2 2
MIRT332935 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442166 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442387 CLVS2 clavesin 2 2 2
MIRT442595 SIX1 SIX homeobox 1 2 2
MIRT448014 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448061 MMP15 matrix metallopeptidase 15 2 2
MIRT489017 C1QTNF6 C1q and TNF related 6 2 2
MIRT494456 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495650 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504016 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506777 KLHL15 kelch like family member 15 2 4
MIRT507229 FOXN2 forkhead box N2 2 4
MIRT512550 MFN2 mitofusin 2 2 6
MIRT512842 A1CF APOBEC1 complementation factor 2 6
MIRT513944 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516103 GADL1 glutamate decarboxylase like 1 2 4
MIRT519831 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523210 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525008 ACTN4 actinin alpha 4 2 6
MIRT528858 PKP1 plakophilin 1 2 2
MIRT529062 ZNF675 zinc finger protein 675 2 2
MIRT531719 TARS threonyl-tRNA synthetase 2 2
MIRT534039 STK4 serine/threonine kinase 4 2 2
MIRT543848 APIP APAF1 interacting protein 2 2
MIRT545866 ZNF264 zinc finger protein 264 2 4
MIRT556037 MXD1 MAX dimerization protein 1 2 2
MIRT557081 HOXB3 homeobox B3 2 2
MIRT561345 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562705 ZNF415 zinc finger protein 415 2 2
MIRT563223 ZNF286A zinc finger protein 286A 2 2
MIRT563860 ZNF616 zinc finger protein 616 2 4
MIRT563879 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564652 ZNF487P zinc finger protein 487 1 1
MIRT566595 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570878 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573067 TRIB1 tribbles pseudokinase 1 2 2
MIRT573941 ZNF708 zinc finger protein 708 2 2
MIRT575966 Slfn5 schlafen 5 2 5
MIRT607293 CD300E CD300e molecule 2 4
MIRT608187 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609537 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610152 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611571 SLFN5 schlafen family member 5 2 7
MIRT613335 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616560 ZNF512B zinc finger protein 512B 2 2
MIRT617240 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618011 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618478 IL17REL interleukin 17 receptor E like 2 2
MIRT619099 IFI44L interferon induced protein 44 like 2 2
MIRT622265 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623080 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625621 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627844 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630459 GMPS guanine monophosphate synthase 2 2
MIRT630524 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631502 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634537 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638807 DCTN3 dynactin subunit 3 2 2
MIRT641303 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648347 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649705 ZNF175 zinc finger protein 175 2 2
MIRT652554 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655564 P2RX7 purinergic receptor P2X 7 2 2
MIRT659065 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660341 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664330 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688934 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689971 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699514 SKIL SKI like proto-oncogene 2 2
MIRT699975 RREB1 ras responsive element binding protein 1 2 2
MIRT702676 IRS2 insulin receptor substrate 2 2 2
MIRT709357 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709837 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718716 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718879 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724105 TMEM199 transmembrane protein 199 2 2
MIRT724763 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4653-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)

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