pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARHGAP1   
Synonyms CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP
Description Rho GTPase activating protein 1
Transcript NM_004308   
Expression
Putative miRNA Targets on ARHGAP1
3'UTR of ARHGAP1
(miRNA target sites are highlighted)
>ARHGAP1|NM_004308|3'UTR
   1 ACCTGGCCCCTGCCCCACCAGCCCCTTCTCTGGTAGCCCGGGTTTGGACTCTTCCTCCTGGCATCAGGGGCCATGAAGCC
  81 CCCTGGAGAGAGATGTTGGAGCCACCCATCAGGCATGCTCTCCCCCACCTCTGTCCAGCCCGCCTCACGGCCCTGGCGGC
 161 CTCGCTGTTACCAGAAGACGTTTTTCTCTGCCTTACACTTCTCACTGCCTCTCTGGACACCGGGCTTTTGCTGGGCTCTC
 241 CAGAGCTGGGCTTGGCTCTTCCAGCTGGAGAAGGACTGAGCCCCAGTAACCCCTTTCCTGCTTTTTCCTGCCTCTGTTTC
 321 CCTAGCAAGTGTGGATGAATCAAATGACTGCCGGCTGGGCTGGTAGCAGGGGCCAGTCCTCCCCTCTTGATTGCTGGGAA
 401 TGAGCAGCTGAGCTCTTTGGTGTGGACACCGCCCCAAGCTGAGGTGCCTCCCTATCTGGTAGGCTGCCCTGCTTTGCAGA
 481 AGCCCCACTGCATGAAGGCCTGAGTGCAAGCACCCTTGCTCCTGTACTGCCCCCAGCAGCGCAGTCTGGGGTATTTCCCC
 561 TGCTGAGGAGTGACAGGGCTGGAGACTGTGTCTGCTTTCTGCCTCCTCTTCCACACATCCTGGGTCAGCCTTTCCCAAGT
 641 GATACTGCCCCTGGGGTGTCCTAACCCCTTGGTTGTGCAGGGACTGGTAGCTTGGATGACATGGCTCAGAGTCCCAGCAT
 721 CCACTTGAAACCTCCCTCTCCACCTCCCCGCCCCCGAGAGCTACAGCGTGTGATGGAATCAGTGACCGGCCAGGTTAGCC
 801 TCTCCCCTCTTGGCCTCCTTTCCCACACGGGCAGATCATCAGCCTTCATGTTCTTGTGGACCTGTCTGTTACGGAGTCAC
 881 ACTGGCCCCTGCCCCAGCCAGAGGTGACTCAGTGCCTCAGGATCTTATGGCTCCTTCCTCCAGCTGGGGGACTCTTAAAG
 961 GGGCTGGGGTAGAGACTAAGAGTGCCCGTAGGAGGGGCAGAGATTGTGCTGATAGGTCAGTCCAGATAGGTGGGTTCTAG
1041 CAATTTCCCCAGGGGATTAAGGGGCTCTAGGGCCACCTTTTTTTTTTTTTTTCTGAGATGGAGTCTCGCTCTGTCACCAG
1121 GCTGGAGTGCAGTGGCGCGATCTCGGCACACCTCCGCCTTCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAG
1201 CTGGGACTATAGGTGCATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAG
1281 GATGGTCTCGATCTCCTGACCTCATGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTCCAGGCGTGAGCCACTGCG
1361 CCCGGCCAGCCCTGTTGTCTTTCAAAGAACCTCGGCCCCAGTGATGGCTGATCTCACTCCCACTGTCTCGTAGAATTACA
1441 CTCCTTCCTGGGGATCCCTCTTCCTGCAGCCTTGTCCTTGGGGAGTACAGGGAAGTACCTGCAGTGACCCTGCCCCCATG
1521 ACCTTGGCCAGGCAGGATGATTCCAGAGCCCGTACTGTGGGGATCCTCACTGACCAGCCCAGCCCCATCCGCAAGCCAGG
1601 CTGGGCCTGGGCATAACTTCGCTGGGCTCTCCCAAGACCATCAGCAGTGCATCCAGCCCCCTGGGGCCTGGGCTGCTGCT
1681 GGTTCTTCATCAGTCCCTTGGTCTCTAGCCTCGGCCAGGGCTGCTCTGCTCTCCGCCCTCCTTTGTGTATCAAGTGTCGC
1761 TCACAGCCCCATTCACTGGGGAGCCTTTCGGATCTATTTGGTCTTTCTCATGTCCCCCACTGGTCTGTACCCCAGGGAGC
1841 GGGTGCTTGTACTGTGTGAATCCAGTGTTCACATTCACACTTAATGACTTCCTTGGCACCAATCATGTATTTCACCGTTT
1921 GCACTTTTTGTATTTCAATAAAAATGTTGATGCAAAACTGCTAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggucGAUUGUUA--UGUGACGGa 5'
               || ||| |   ||||||| 
Target 5' tctgcCTTACACTTCTCACTGCCt 3'
187 - 210 151.00 -15.90
2
miRNA  3' cgGUCG---AUUGUU-A-UGUGACGGa 5'
            ||||   |  ||| | |:|||||| 
Target 5' gtCAGCCTTTCCCAAGTGATACTGCCc 3'
624 - 650 140.00 -17.70
3
miRNA  3' cgGUCGAUU---GUUA-UGUGACGGa 5'
            ::|||:|   || |  |||||:| 
Target 5' gaTGGCTGATCTCACTCCCACTGTCt 3'
1403 - 1428 136.00 -13.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN29162751 35 COSMIC
COSN31497591 37 COSMIC
COSN30526346 51 COSMIC
COSN30542435 55 COSMIC
COSN28676791 60 COSMIC
COSN2528308 120 COSMIC
COSN26880102 120 COSMIC
COSN16079083 174 COSMIC
COSN29160334 177 COSMIC
COSN16745794 238 COSMIC
COSN1133483 243 COSMIC
COSN26880101 314 COSMIC
COSN19595542 477 COSMIC
COSN17182673 577 COSMIC
COSN8681578 746 COSMIC
COSN20092343 770 COSMIC
COSN30649180 978 COSMIC
COSN28417163 988 COSMIC
COSN19729909 1035 COSMIC
COSN1133481 1062 COSMIC
COSN31782422 1078 COSMIC
COSN20043913 1100 COSMIC
COSN17077193 1102 COSMIC
COSN24399192 1172 COSMIC
COSN1133479 1410 COSMIC
COSN25498732 1678 COSMIC
COSN30161523 1774 COSMIC
COSN31484492 1900 COSMIC
rs8914 1463 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776503174 3 dbSNP
rs1217121991 4 dbSNP
rs200140073 6 dbSNP
rs1348078977 7 dbSNP
rs1163923367 8 dbSNP
rs746554111 11 dbSNP
rs1386937143 12 dbSNP
rs1186432279 13 dbSNP
rs779566476 17 dbSNP
rs1247609866 22 dbSNP
rs1429112464 25 dbSNP
rs757833476 28 dbSNP
rs745530209 30 dbSNP
rs747804640 33 dbSNP
rs375122405 36 dbSNP
rs1360788537 37 dbSNP
rs74719156 39 dbSNP
rs201102767 40 dbSNP
rs34425129 40 dbSNP
rs1364054118 41 dbSNP
rs1295791490 42 dbSNP
rs957008670 45 dbSNP
rs924251761 46 dbSNP
rs1364800570 48 dbSNP
rs965765631 48 dbSNP
rs545629923 55 dbSNP
rs111724531 57 dbSNP
rs956902175 61 dbSNP
rs1271060957 80 dbSNP
rs186966152 81 dbSNP
rs563813368 82 dbSNP
rs1402705765 94 dbSNP
rs536215452 103 dbSNP
rs1031631282 126 dbSNP
rs1345239193 128 dbSNP
rs976651965 139 dbSNP
rs1272309823 141 dbSNP
rs1298051877 142 dbSNP
rs1001121527 148 dbSNP
rs573961587 149 dbSNP
rs557104184 153 dbSNP
rs1361212707 157 dbSNP
rs1220503853 158 dbSNP
rs753661932 164 dbSNP
rs1174366135 171 dbSNP
rs1414296809 174 dbSNP
rs1424022399 179 dbSNP
rs1006200807 180 dbSNP
rs1475041788 197 dbSNP
rs1163831349 204 dbSNP
rs1415304527 205 dbSNP
rs887796745 213 dbSNP
rs1162409777 219 dbSNP
rs12418414 221 dbSNP
rs1320614708 222 dbSNP
rs1260455569 225 dbSNP
rs1192794797 245 dbSNP
rs1483526618 249 dbSNP
rs1285348053 255 dbSNP
rs993603844 263 dbSNP
rs1239178527 271 dbSNP
rs11038969 273 dbSNP
rs1207752117 274 dbSNP
rs11602528 276 dbSNP
rs768700395 280 dbSNP
rs1311450636 284 dbSNP
rs907242432 286 dbSNP
rs1259384203 293 dbSNP
rs1446262415 296 dbSNP
rs1188129984 297 dbSNP
rs182359020 298 dbSNP
rs1012221532 306 dbSNP
rs1239090332 307 dbSNP
rs190916764 308 dbSNP
rs1182378684 310 dbSNP
rs534530128 311 dbSNP
rs1421131635 316 dbSNP
rs565802212 319 dbSNP
rs940481750 320 dbSNP
rs1415523915 322 dbSNP
rs1400528437 327 dbSNP
rs1381927882 329 dbSNP
rs1385546371 335 dbSNP
rs886272540 337 dbSNP
rs746463119 341 dbSNP
rs779756810 350 dbSNP
rs930562252 352 dbSNP
rs921866688 353 dbSNP
rs779696057 357 dbSNP
rs974380430 362 dbSNP
rs944364472 365 dbSNP
rs1355487887 369 dbSNP
rs1200770439 375 dbSNP
rs74486166 384 dbSNP
rs924284265 389 dbSNP
rs1182981014 409 dbSNP
rs988562334 412 dbSNP
rs1238235145 416 dbSNP
rs956021712 430 dbSNP
rs1179181629 431 dbSNP
rs1031159890 432 dbSNP
rs980033221 433 dbSNP
rs1478161924 445 dbSNP
rs1173458793 454 dbSNP
rs968306528 457 dbSNP
rs1023855127 459 dbSNP
rs933793125 470 dbSNP
rs1012170816 471 dbSNP
rs976304349 476 dbSNP
rs964829319 477 dbSNP
rs1214638269 480 dbSNP
rs113021913 484 dbSNP
rs896496052 488 dbSNP
rs1304984924 490 dbSNP
rs1169305574 493 dbSNP
rs1335335828 495 dbSNP
rs371459888 496 dbSNP
rs751835634 500 dbSNP
rs1284953863 502 dbSNP
rs1321225722 519 dbSNP
rs1004962860 524 dbSNP
rs563294114 533 dbSNP
rs1202929115 534 dbSNP
rs1180062163 536 dbSNP
rs1482766161 537 dbSNP
rs1238591967 539 dbSNP
rs573236437 540 dbSNP
rs886551111 541 dbSNP
rs549845110 542 dbSNP
rs1481592202 543 dbSNP
rs1193516101 553 dbSNP
rs1249219099 555 dbSNP
rs1451821984 561 dbSNP
rs1200631618 567 dbSNP
rs1017703522 577 dbSNP
rs878914422 578 dbSNP
rs1048865959 585 dbSNP
rs1026317158 588 dbSNP
rs907314891 592 dbSNP
rs993898589 592 dbSNP
rs1395945701 593 dbSNP
rs1387551377 594 dbSNP
rs1305237535 599 dbSNP
rs1311130852 602 dbSNP
rs578075163 603 dbSNP
rs1222628646 608 dbSNP
rs1378047462 614 dbSNP
rs1278630651 616 dbSNP
rs1309120002 618 dbSNP
rs764292424 621 dbSNP
rs1333762215 624 dbSNP
rs1445081480 643 dbSNP
rs1488551639 644 dbSNP
rs930488265 649 dbSNP
rs1266277553 651 dbSNP
rs1012979904 652 dbSNP
rs35630896 652 dbSNP
rs779468721 653 dbSNP
rs900389619 656 dbSNP
rs77231427 665 dbSNP
rs1038977665 668 dbSNP
rs1430805056 675 dbSNP
rs894328048 679 dbSNP
rs1457920714 681 dbSNP
rs944315487 682 dbSNP
rs1363888854 691 dbSNP
rs1404578076 700 dbSNP
rs1298580357 701 dbSNP
rs1363888377 702 dbSNP
rs1380439502 704 dbSNP
rs911556130 708 dbSNP
rs1322289132 718 dbSNP
rs988915872 722 dbSNP
rs903102111 723 dbSNP
rs1358200790 731 dbSNP
rs1041414031 733 dbSNP
rs933635562 739 dbSNP
rs762979392 742 dbSNP
rs533021391 749 dbSNP
rs1380890940 750 dbSNP
rs564171046 755 dbSNP
rs1180244039 756 dbSNP
rs922398460 763 dbSNP
rs1437664823 764 dbSNP
rs145637002 767 dbSNP
rs543187938 768 dbSNP
rs979596706 770 dbSNP
rs1160176769 772 dbSNP
rs968630188 776 dbSNP
rs1263783566 777 dbSNP
rs1220991282 786 dbSNP
rs140588272 787 dbSNP
rs113687063 788 dbSNP
rs1454515783 793 dbSNP
rs919490426 799 dbSNP
rs1238419267 807 dbSNP
rs77863447 811 dbSNP
rs1305769811 817 dbSNP
rs971823015 820 dbSNP
rs1260515782 828 dbSNP
rs1462155524 829 dbSNP
rs557314724 831 dbSNP
rs1024281837 832 dbSNP
rs1392193945 835 dbSNP
rs1444133319 836 dbSNP
rs1291264131 840 dbSNP
rs1410377133 841 dbSNP
rs1417573165 848 dbSNP
rs1158021177 849 dbSNP
rs1406628955 850 dbSNP
rs1013015458 861 dbSNP
rs1334667965 864 dbSNP
rs1404680021 870 dbSNP
rs958741589 870 dbSNP
rs1032887682 871 dbSNP
rs1160442679 872 dbSNP
rs1222851499 873 dbSNP
rs1306725380 882 dbSNP
rs537056868 884 dbSNP
rs1417569553 886 dbSNP
rs903127546 887 dbSNP
rs1261775126 893 dbSNP
rs1461281406 900 dbSNP
rs577688051 901 dbSNP
rs1205237020 904 dbSNP
rs1234679190 908 dbSNP
rs1034972261 918 dbSNP
rs1176897207 944 dbSNP
rs1429706395 950 dbSNP
rs557845614 953 dbSNP
rs1435107895 956 dbSNP
rs1174027157 961 dbSNP
rs1428450052 962 dbSNP
rs1330233421 965 dbSNP
rs762530633 965 dbSNP
rs1352324432 966 dbSNP
rs756159367 967 dbSNP
rs1190680253 976 dbSNP
rs1347047543 980 dbSNP
rs998088134 988 dbSNP
rs1281786858 994 dbSNP
rs1323369815 1002 dbSNP
rs1215741206 1010 dbSNP
rs1275187017 1016 dbSNP
rs1292433320 1021 dbSNP
rs886499955 1022 dbSNP
rs1028165375 1023 dbSNP
rs1367348205 1026 dbSNP
rs1166526604 1030 dbSNP
rs1428822991 1032 dbSNP
rs1389807032 1034 dbSNP
rs1171327563 1038 dbSNP
rs1430385781 1039 dbSNP
rs1416738761 1049 dbSNP
rs1408825035 1051 dbSNP
rs994644520 1055 dbSNP
rs534826702 1059 dbSNP
rs1265439608 1061 dbSNP
rs1163697567 1064 dbSNP
rs1190667763 1070 dbSNP
rs767711538 1075 dbSNP
rs1271638885 1077 dbSNP
rs1301674389 1078 dbSNP
rs1330946545 1078 dbSNP
rs534743131 1082 dbSNP
rs774773825 1085 dbSNP
rs909632513 1087 dbSNP
rs1229242863 1090 dbSNP
rs766622593 1091 dbSNP
rs11038968 1092 dbSNP
rs1361772454 1093 dbSNP
rs1419318413 1093 dbSNP
rs34845803 1093 dbSNP
rs746218027 1093 dbSNP
rs754474121 1093 dbSNP
rs762964369 1093 dbSNP
rs769946535 1093 dbSNP
rs771426543 1094 dbSNP
rs1404998235 1096 dbSNP
rs1347357006 1097 dbSNP
rs1306056172 1099 dbSNP
rs1409002186 1100 dbSNP
rs1475051501 1102 dbSNP
rs572398062 1102 dbSNP
rs1396862089 1107 dbSNP
rs1299662545 1108 dbSNP
rs919410037 1110 dbSNP
rs1376106232 1111 dbSNP
rs1401608969 1113 dbSNP
rs569864031 1115 dbSNP
rs972739970 1116 dbSNP
rs1435013892 1117 dbSNP
rs1480780043 1119 dbSNP
rs545612403 1120 dbSNP
rs1180572238 1121 dbSNP
rs1483014416 1125 dbSNP
rs917243122 1135 dbSNP
rs1038925311 1136 dbSNP
rs1197903270 1137 dbSNP
rs532976486 1138 dbSNP
rs775345129 1139 dbSNP
rs1244424734 1140 dbSNP
rs570524553 1144 dbSNP
rs547497996 1145 dbSNP
rs1286384640 1148 dbSNP
rs370839041 1149 dbSNP
rs1336263888 1151 dbSNP
rs967633436 1152 dbSNP
rs1394033806 1155 dbSNP
rs559893787 1156 dbSNP
rs542892016 1159 dbSNP
rs1336264051 1160 dbSNP
rs1470349094 1162 dbSNP
rs1408479435 1163 dbSNP
rs770595462 1165 dbSNP
rs1470120379 1170 dbSNP
rs925692108 1174 dbSNP
rs1184466957 1177 dbSNP
rs901050565 1178 dbSNP
rs1043203292 1180 dbSNP
rs1255065599 1182 dbSNP
rs1203835743 1183 dbSNP
rs1462374625 1187 dbSNP
rs1336510684 1188 dbSNP
rs1241529674 1190 dbSNP
rs1265756483 1205 dbSNP
rs1277544430 1210 dbSNP
rs1328282507 1213 dbSNP
rs1407865696 1214 dbSNP
rs1426767207 1216 dbSNP
rs748843428 1217 dbSNP
rs778230775 1218 dbSNP
rs756367985 1226 dbSNP
rs1264881241 1227 dbSNP
rs1459942277 1228 dbSNP
rs1199330999 1232 dbSNP
rs1039383155 1235 dbSNP
rs1242366064 1244 dbSNP
rs948513688 1251 dbSNP
rs916741572 1258 dbSNP
rs1279518066 1259 dbSNP
rs1472447309 1276 dbSNP
rs1177634110 1284 dbSNP
rs1432010950 1285 dbSNP
rs1397639174 1289 dbSNP
rs1325784384 1290 dbSNP
rs1006503735 1307 dbSNP
rs990978674 1316 dbSNP
rs1405275981 1317 dbSNP
rs1334820311 1319 dbSNP
rs527446127 1320 dbSNP
rs960925433 1323 dbSNP
rs529549507 1324 dbSNP
rs888220743 1333 dbSNP
rs928236455 1337 dbSNP
rs563642114 1347 dbSNP
rs555600482 1348 dbSNP
rs1250552498 1357 dbSNP
rs543378729 1359 dbSNP
rs10734547 1360 dbSNP
rs1369534476 1363 dbSNP
rs1027699779 1364 dbSNP
rs577599757 1372 dbSNP
rs374193595 1387 dbSNP
rs796192547 1387 dbSNP
rs1036495060 1391 dbSNP
rs950392330 1393 dbSNP
rs964823636 1394 dbSNP
rs762922329 1400 dbSNP
rs1017435605 1411 dbSNP
rs1216241184 1413 dbSNP
rs1386120894 1415 dbSNP
rs1296254903 1417 dbSNP
rs1328154077 1422 dbSNP
rs560110773 1429 dbSNP
rs1224333415 1430 dbSNP
rs557759467 1430 dbSNP
rs76684547 1433 dbSNP
rs773112647 1437 dbSNP
rs1294379565 1440 dbSNP
rs1246944795 1443 dbSNP
rs1338436172 1454 dbSNP
rs8914 1463 dbSNP
rs998493719 1466 dbSNP
rs1186674636 1468 dbSNP
rs1389698000 1482 dbSNP
rs904187232 1499 dbSNP
rs978853037 1504 dbSNP
rs572489215 1511 dbSNP
rs116900887 1512 dbSNP
rs915686868 1519 dbSNP
rs1457177984 1526 dbSNP
rs1289246288 1527 dbSNP
rs1386966079 1534 dbSNP
rs1380524900 1536 dbSNP
rs1296214592 1538 dbSNP
rs1329624730 1549 dbSNP
rs75921811 1551 dbSNP
rs796516163 1552 dbSNP
rs1320765118 1555 dbSNP
rs928202511 1556 dbSNP
rs965708803 1558 dbSNP
rs1261678531 1561 dbSNP
rs1018128814 1569 dbSNP
rs1006739008 1570 dbSNP
rs1247467043 1578 dbSNP
rs888127129 1583 dbSNP
rs984110308 1589 dbSNP
rs1165463800 1590 dbSNP
rs1159561460 1596 dbSNP
rs951035193 1602 dbSNP
rs920584416 1612 dbSNP
rs973429357 1613 dbSNP
rs1406779895 1620 dbSNP
rs1026575356 1621 dbSNP
rs1334135458 1631 dbSNP
rs994326966 1632 dbSNP
rs964771595 1633 dbSNP
rs1308137286 1635 dbSNP
rs1319156145 1637 dbSNP
rs112881605 1639 dbSNP
rs1268008746 1640 dbSNP
rs1441996069 1640 dbSNP
rs1239557497 1650 dbSNP
rs1196378013 1657 dbSNP
rs1436687263 1659 dbSNP
rs1289999875 1662 dbSNP
rs1008702872 1665 dbSNP
rs151329376 1672 dbSNP
rs1354125292 1682 dbSNP
rs1252370720 1695 dbSNP
rs1031545427 1705 dbSNP
rs999173447 1712 dbSNP
rs896091292 1713 dbSNP
rs1314373506 1715 dbSNP
rs1429838385 1719 dbSNP
rs539776370 1721 dbSNP
rs570438481 1734 dbSNP
rs547461843 1735 dbSNP
rs1358126310 1737 dbSNP
rs188403897 1739 dbSNP
rs1441791367 1744 dbSNP
rs1245753318 1745 dbSNP
rs568071189 1746 dbSNP
rs866599971 1747 dbSNP
rs549507608 1756 dbSNP
rs1331702884 1758 dbSNP
rs773039709 1759 dbSNP
rs78655636 1764 dbSNP
rs913308542 1783 dbSNP
rs1311722126 1787 dbSNP
rs563574754 1789 dbSNP
rs939480690 1790 dbSNP
rs1253244569 1792 dbSNP
rs906691338 1793 dbSNP
rs1181102062 1798 dbSNP
rs543687163 1801 dbSNP
rs1269414809 1803 dbSNP
rs771734225 1813 dbSNP
rs1189449446 1814 dbSNP
rs1423817170 1820 dbSNP
rs746654669 1821 dbSNP
rs1159801003 1828 dbSNP
rs1421838866 1830 dbSNP
rs1368250123 1834 dbSNP
rs570572058 1836 dbSNP
rs1378892927 1840 dbSNP
rs929534574 1841 dbSNP
rs547404628 1845 dbSNP
rs1469292312 1846 dbSNP
rs1246963704 1848 dbSNP
rs1200364140 1850 dbSNP
rs564131428 1852 dbSNP
rs1018033775 1853 dbSNP
rs541078810 1854 dbSNP
rs528470512 1859 dbSNP
rs1340293865 1870 dbSNP
rs1204774064 1875 dbSNP
rs1355535258 1876 dbSNP
rs1490790791 1879 dbSNP
rs1219147032 1880 dbSNP
rs1246004719 1884 dbSNP
rs879603768 1895 dbSNP
rs973373885 1900 dbSNP
rs1223049831 1904 dbSNP
rs952591141 1905 dbSNP
rs1026645592 1907 dbSNP
rs866527517 1916 dbSNP
rs1163873197 1917 dbSNP
rs572459344 1920 dbSNP
rs527241385 1922 dbSNP
rs1407388435 1926 dbSNP
rs1322004825 1938 dbSNP
rs1276891417 1940 dbSNP
rs184809558 1943 dbSNP
rs369365882 1949 dbSNP
rs1344973249 1952 dbSNP
rs775180226 1955 dbSNP
rs1363172035 1956 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cggucGAUUGUUA--UGUGACGGa 5'
               || ||| |   ||||||| 
Target 5' ucugcCUUACACUUCUCACUGCCu 3'
7 - 30
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 392.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cggucGAUUGUUA--UGUGACGGa 5'
               || ||| |   ||||||| 
Target 5' ucugcCUUACACUUCUCACUGCCu 3'
6 - 29
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760597. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000311956.4 | 3UTR | UUUUUCUCUGCCUUACACUUCUCACUGCCUCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000311956.4 | 3UTR | UUUUCUCUGCCUUACACUUCUCACUGCCUCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000311956.4 | 3UTR | UUCUCUGCCUUACACUUCUCACUGCCUCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.578 1.9e-2 0.440 6.6e-2 13 Click to see details
GSE28544 Breast cancer -0.404 2.5e-2 -0.544 3.0e-3 24 Click to see details
GSE19350 CNS germ cell tumors 0.545 3.3e-2 0.252 2.1e-1 12 Click to see details
GSE19536 Breast cancer 0.176 4.0e-2 0.154 6.3e-2 100 Click to see details
GSE17498 Multiple myeloma 0.28 4.0e-2 0.017 4.6e-1 40 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.612 5.3e-2 -0.881 1.9e-3 8 Click to see details
GSE26953 Aortic valvular endothelial cells -0.332 5.6e-2 -0.349 4.7e-2 24 Click to see details
GSE19783 ER- ER- breast cancer 0.178 5.8e-2 0.252 1.3e-2 79 Click to see details
GSE17306 Multiple myeloma -0.201 8.3e-2 0.111 2.2e-1 49 Click to see details
GSE27834 Pluripotent stem cells 0.321 1.1e-1 -0.232 1.9e-1 16 Click to see details
GSE19783 ER+ ER+ breast cancer 0.268 1.3e-1 0.090 3.5e-1 20 Click to see details
GSE32688 Pancreatic cancer -0.109 2.8e-1 -0.101 2.9e-1 32 Click to see details
GSE21849 B cell lymphoma 0.072 3.6e-1 0.233 1.1e-1 29 Click to see details
GSE14794 Lymphoblastoid cells 0.038 3.6e-1 0.014 4.5e-1 90 Click to see details
GSE42095 Differentiated embryonic stem cells 0.067 3.8e-1 0.208 1.7e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.066 3.9e-1 0.535 7.5e-3 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.054 4.0e-1 0.076 3.6e-1 25 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.05 4.1e-1 0.100 3.2e-1 25 Click to see details
GSE38226 Liver fibrosis 0.031 4.5e-1 -0.032 4.5e-1 21 Click to see details
GSE21687 Ependynoma primary tumors 0.017 4.5e-1 -0.066 3.0e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.814 0.09 -0.800 0.1 4 Click to see details
UCEC 0.273 0.26 0.262 0.27 8 Click to see details
THCA -0.37 0.38 -0.500 0.33 3 Click to see details
LUSC -0.227 0.39 -0.800 0.1 4 Click to see details
LUSC -0.227 0.39 -0.800 0.1 4 Click to see details
LUSC -0.227 0.39 -0.800 0.1 4 Click to see details
LUSC -0.227 0.39 -0.800 0.1 4 Click to see details
LUSC -0.227 0.39 -0.800 0.1 4 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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