pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-4291 |
Genomic Coordinates | chr9: 93819357 - 93819421 |
Description | Homo sapiens miR-4291 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-4291 | ||||||||||||
Sequence | 11| UUCAGCAGGAACAGCU |26 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | SOLiD | ||||||||||||
SNPs in miRNA |
|
||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | HEYL | ||||||||||||||||||||
Synonyms | HESR3, HEY3, HRT3, bHLHb33 | ||||||||||||||||||||
Description | hes related family bHLH transcription factor with YRPW motif-like | ||||||||||||||||||||
Transcript | NM_014571 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on HEYL | |||||||||||||||||||||
3'UTR of HEYL (miRNA target sites are highlighted) |
>HEYL|NM_014571|3'UTR 1 GCTGCCCCTTCACCACCCCGCCCCAAGGAATAAGGAAGGTTCTTTTACCAGGAGCCCAAAAAAGGGCACTGCCTTTTCTG 81 CTTTGCTTCATGGACTGGCTCATATGTGAAGGCACGTTCTCCAGCCATCAGAGGCCCCCTCCTCCTCCAACCCATCTCTC 161 CTTCTCACTGTTATCCCAGCTTATCCACCCAGCTCTCCTGGAGCTGTTCTGGTCTCAGAGGCTTGGTTCCATTTCTCACC 241 TGAACAGATGAGTCCTGGGAGAGACCCTCAGAGATCCGCCCAGACCCCTCTCCTGCCCTCTGCACACCAGCAGCAGGCAT 321 GAACCTTGGGTCTGGGAAAAAGCTTTAACCTGCAGGGCACCAGGACCCAAGGCAGGCTGTTCCTTGGGGCGGTCAGACCC 401 CAGTCAGGAGCAATGACTGACTGGCTGCAGCCTTCCCACGCCAAGAGGCTGGAACATAGTGTCTGCCTCGCTTCCTGGAG 481 ATAGTAACTGAGCAGGGGCTACAAAGAGGTCTCCTGGGAACCCTGTCTGCCCCTTCCCACCTGTCCTTGGGCCACACCAT 561 CACACTGAACCACAGGACAGACCCTTTCTCCACCACAGCCAAGGCCTGGAGACTGGGGGCCCAGCAGAGCCTGCTCCCAC 641 CCTCCTCCCAGCAGCAGACACCCACCCTCTCACTGACTAACAGGTCCCTGCACACAGCTGGCCTGGTAAACCCAGCTGGG 721 AGGTTTCTAGGCAGCAGCAAAACTCTGTGACAGGGTGTCCTCACACCAGGCCTTGGACAGCTCTCCCAGACAGGAGCCAG 801 GGTTGAGCAATGGAGAGCCCAGCCCCCACGTCTTACAGTCGCCATCCTCCAGGCGTGTGGTCCCTCCCCATTGGGTGCAC 881 AGTGCAGAGGGGCCGTGGCCCCATGTGATGGTGCGCAGAGAGGAACCTCTTGGGATTCAGCACCAGACGTCTGTGCTGCC 961 TGGTTTGCATCCGGCTCACAGAGCCCAGACTGCTGGAACAGCCAAGGACTGTCAGGCTGGACAAAAATAACTGCAAGGAG 1041 GGGCAAGAGAAAGGATGATTCGAGGCACCTTGGCCCTTCAAGGTCATGCAGTGGGTCGAGCGCCTGAGATCCTGTTCACC 1121 AGGACTCCACAGAGCTGGCTCTGCTCAGAAGCCATTTCATTCCCCGGCTCCACCCTAGGCCACTTTTTCTAACAGAGGAA 1201 ACAAATGGTCCAGCAGTCGTTCCCAGCAGAACAGCGGAGCCTGGACTGACACCCAGTGGGACCAGTGTTGCCACACCAGT 1281 TGATAAAATGCAGAAACCCTTCTGTACTCGTTGGTAAATATCTACTCCCCCAAGTGACTCCAGGTGCCCCCCACCGCCTG 1361 GCACTTCCCCCAGGACTCCTACGATCTGGTTACTGCCTGGCCGATCCAAGGCTGTGGAGTCCCAGAGCCAGCAGTTCACT 1441 GGTGCTCATTCCACACTGGTTAGATACTTCAGTTGTCACCCCTGGGAAGATTCTCCCACCTCCTCCCTTTGATGGAACCA 1521 CCCTCCCCAGAGGCTGCATTGAGGAGACTCCACAGACTGAAAAGTGAGTTTGCAGAAACCTTGGGGAAAAGGGCCCTTTC 1601 AAAGAAGTGGATAAGAGGGAGGAGATCATTGAGTGACCCAGAAAGCTCTTTTGAAAAGACAGACTCCTCAAGGAGAGATA 1681 AAGAGGAAAGCACCTCTTTCATTTTTTAGTGTGAGCTAATTCCATCAGACTGCTGTCCTCCTGGACCCATCTGAGATGTG 1761 CAGTAGCAAGGAGAGGGGGGATCATTTTAGAGAGTGGGTCATTGGCAGGGAGTGCTCCGGAGGGAGGCAGAGGGGAGACT 1841 GTGGTAGAAGGAAGACAGAACTCACACATGCTCCCAGGATTGGGGACAGGGACAGAGGAGGTAACAGAAGGCAAAGGCCA 1921 GTTTCCCCGTTATCATGAAGGGGCCCACTCAGGACAGGAACAAGGACAACTCCTCCTCCTCCTCCTCCTCTCCTGCTGCT 2001 CCTGGGATACCAGGTCAGTGATGTAGTCTTGCAGTTTGGCAACTTCCTAGCCTGAGAATCCCTAGTGGGGCTGTGGGAAA 2081 CACATTTCCACGTTGCAAGCATGCAACTCCAAAGAATCTGTGATGCCACTGAAATGAGATGGGAATGATCCAGCTCTTTC 2161 AGCATCTTGGTTGAACTTGCTTTCATTGTCCCTGGGATATTGTGGAAGGAAAGGTGACTGTGTGATCTGATTCTGTGGTC 2241 AAGGACTTGCATCTTGTGTTTCTATCCCCAAGCCTTCCTGGTGTCTCCAACTCCTACCCCATTGCATGGGTTGTTGCGGA 2321 CATCCAATAAAGATTTTTTTAGTGCTTCTGGAAACTTCCAGTAGATTCTACTTCTAAACTATCTCTGGAGTCCATCCACT 2401 TCTGTCTGCACCCACAGCCATCCTGGCCAGGCCACATCACCTCCCCCAGATCACTGCCCTGGCCTCAGAAAGGTCTTCCC 2481 TCTTGCTTTGTCAATCAGTTCTCAGTAGCAGCAGAGAGAAATTGAAAGCTGCAGGTCATATCGTATCATCTTTAGTTTGA 2561 AAACCTCACTCTCTTACCCTATTGTTCTAAAGGTCTTCTTTTGGTCCCAACCTCATTTCCAGCCTCATTTCTTGCCAGTC 2641 CCAGACTTGCTCCCTGAGCTTCTGCCACCTGCCCTTCCTTCATTTCCTCGACATTCCAGCCTTGTTCCCACCTCCAGCAC 2721 TTTGCATATGCTGTTCCCTTTGCCAAGAATGCTCTTCCCCTACCCTGTGCATGGCTGAGTTCTGCAGACCCTCAGGCCTT 2801 GGCTTCAACGTTGCCTCGTCCAAGAGGCCTTCCTCGACTACTTTACTTGTGGAGTTCCTCTATCACAAGGCCTCTGTTCT 2881 TTCCCTTCATGGAGAATTTGCCACTGCATATCCATTTGTGTAATTTACTTGTTGGTTGACTGTGCCTCCCACTCGAGTGT 2961 AAGCTCATGAGGCCAGGTGCCATGCCTGGTTCAGTCTCCACTCTGTACCCAGCATTGAGCACAGGGCCTGGTCCATAGTT 3041 GGCGTTCAATAAATACTTGTTGAAGAAGTGAACTGAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | LCL-BAC-D2 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM1133252. RNA binding protein: AGO2. Condition:Untreated
... - Majoros WH; Lekprasert P; Mukherjee N; et al., 2013, Nature methods. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Majoros WH; Lekprasert P; Mukherjee N; et al. - Nature methods, 2013
High-throughput sequencing has opened numerous possibilities for the identification of regulatory RNA-binding events. Cross-linking and immunoprecipitation of Argonaute proteins can pinpoint a microRNA (miRNA) target site within tens of bases but leaves the identity of the miRNA unresolved. A flexible computational framework, microMUMMIE, integrates sequence with cross-linking features and reliably identifies the miRNA family involved in each binding event. It considerably outperforms sequence-only approaches and quantifies the prevalence of noncanonical binding modes.
LinkOut: [PMID: 23708386]
|
CLIP-seq Support 1 for dataset GSM1133252 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | LCL-BAC-D2 / Untreated |
Location of target site | ENST00000372852.3 | 3UTR | UUGGGCUGCUGAGAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23708386 / GSE46611 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT102445 | CALU | calumenin | ![]() |
![]() |
2 | 4 | ||||||
MIRT108677 | ZBTB33 | zinc finger and BTB domain containing 33 | ![]() |
![]() |
2 | 4 | ||||||
MIRT125969 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
![]() |
2 | 6 | ||||||
MIRT179018 | PAFAH1B2 | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT379033 | CDK6 | cyclin dependent kinase 6 | ![]() |
![]() |
2 | 6 | ||||||
MIRT442473 | CPEB4 | cytoplasmic polyadenylation element binding protein 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT442910 | PCBD2 | pterin-4 alpha-carbinolamine dehydratase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT442979 | ZNF736 | zinc finger protein 736 | ![]() |
![]() |
2 | 2 | ||||||
MIRT445663 | TNFSF15 | TNF superfamily member 15 | ![]() |
![]() |
2 | 2 | ||||||
MIRT446237 | FZD6 | frizzled class receptor 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT448860 | FAM49B | family with sequence similarity 49 member B | ![]() |
![]() |
2 | 2 | ||||||
MIRT455559 | TRAF1 | TNF receptor associated factor 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT459704 | ZNF641 | zinc finger protein 641 | ![]() |
![]() |
2 | 2 | ||||||
MIRT460608 | FEM1A | fem-1 homolog A | ![]() |
![]() |
2 | 2 | ||||||
MIRT462251 | LAMA4 | laminin subunit alpha 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT462469 | FIZ1 | FLT3 interacting zinc finger 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT466656 | TAF1D | TATA-box binding protein associated factor, RNA polymerase I subunit D | ![]() |
![]() |
2 | 6 | ||||||
MIRT466841 | STX6 | syntaxin 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT471403 | PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT471517 | PCGF3 | polycomb group ring finger 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT471681 | PABPN1 | poly(A) binding protein nuclear 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT472858 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | ![]() |
![]() |
2 | 2 | ||||||
MIRT474813 | KIAA0226 | RUN and cysteine rich domain containing beclin 1 interacting protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT474931 | KCTD15 | potassium channel tetramerization domain containing 15 | ![]() |
![]() |
2 | 2 | ||||||
MIRT475814 | HDGF | heparin binding growth factor | ![]() |
![]() |
2 | 2 | ||||||
MIRT480434 | C17orf49 | chromosome 17 open reading frame 49 | ![]() |
![]() |
2 | 2 | ||||||
MIRT480903 | BCL2L2-PABPN1 | BCL2L2-PABPN1 readthrough | ![]() |
![]() |
2 | 2 | ||||||
MIRT481478 | ARL8B | ADP ribosylation factor like GTPase 8B | ![]() |
![]() |
2 | 2 | ||||||
MIRT484982 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
![]() |
2 | 8 | ||||||
MIRT485019 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
![]() |
2 | 8 | ||||||
MIRT485036 | TMEM189 | transmembrane protein 189 | ![]() |
![]() |
2 | 8 | ||||||
MIRT495074 | HEYL | hes related family bHLH transcription factor with YRPW motif-like | ![]() |
![]() |
2 | 2 | ||||||
MIRT496004 | CD180 | CD180 molecule | ![]() |
![]() |
2 | 2 | ||||||
MIRT500675 | TRIM37 | tripartite motif containing 37 | ![]() |
![]() |
2 | 2 | ||||||
MIRT504544 | ZNF417 | zinc finger protein 417 | ![]() |
![]() |
2 | 6 | ||||||
MIRT506782 | KLHL15 | kelch like family member 15 | ![]() |
![]() |
2 | 6 | ||||||
MIRT507256 | FGF2 | fibroblast growth factor 2 | ![]() |
![]() |
2 | 6 | ||||||
MIRT507386 | EN2 | engrailed homeobox 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT512505 | BTBD19 | BTB domain containing 19 | ![]() |
![]() |
2 | 2 | ||||||
MIRT516903 | CTSB | cathepsin B | ![]() |
![]() |
2 | 2 | ||||||
MIRT528124 | PPP1R10 | protein phosphatase 1 regulatory subunit 10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT528874 | ATF3 | activating transcription factor 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT536091 | MBOAT2 | membrane bound O-acyltransferase domain containing 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT541079 | RLIM | ring finger protein, LIM domain interacting | ![]() |
![]() |
2 | 2 | ||||||
MIRT541099 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase | ![]() |
![]() |
2 | 2 | ||||||
MIRT545360 | LIN7C | lin-7 homolog C, crumbs cell polarity complex component | ![]() |
![]() |
2 | 2 | ||||||
MIRT545831 | ZNF367 | zinc finger protein 367 | ![]() |
![]() |
2 | 4 | ||||||
MIRT547115 | PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT547312 | NPTN | neuroplastin | ![]() |
![]() |
2 | 2 | ||||||
MIRT547959 | HIGD1A | HIG1 hypoxia inducible domain family member 1A | ![]() |
![]() |
2 | 4 | ||||||
MIRT549943 | RPL7L1 | ribosomal protein L7 like 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT550749 | ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT565145 | TUBB2A | tubulin beta 2A class IIa | ![]() |
![]() |
2 | 2 | ||||||
MIRT571050 | POLQ | DNA polymerase theta | ![]() |
![]() |
2 | 2 | ||||||
MIRT571361 | ZNF45 | zinc finger protein 45 | ![]() |
![]() |
2 | 2 | ||||||
MIRT610133 | FOXI2 | forkhead box I2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT613145 | DSE | dermatan sulfate epimerase | ![]() |
![]() |
2 | 2 | ||||||
MIRT613379 | ABCC12 | ATP binding cassette subfamily C member 12 | ![]() |
![]() |
2 | 2 | ||||||
MIRT615752 | C6 | complement C6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT616460 | ADRA2B | adrenoceptor alpha 2B | ![]() |
![]() |
2 | 2 | ||||||
MIRT616719 | FEM1B | fem-1 homolog B | ![]() |
![]() |
2 | 2 | ||||||
MIRT618312 | IPP | intracisternal A particle-promoted polypeptide | ![]() |
![]() |
2 | 2 | ||||||
MIRT631491 | RASSF4 | Ras association domain family member 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT643134 | PLCXD2 | phosphatidylinositol specific phospholipase C X domain containing 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT643482 | DISC1 | disrupted in schizophrenia 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT649715 | TWSG1 | twisted gastrulation BMP signaling modulator 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT653542 | SLC38A7 | solute carrier family 38 member 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT666307 | SLC22A3 | solute carrier family 22 member 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT692005 | NAP1L4 | nucleosome assembly protein 1 like 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT696838 | ARL2BP | ADP ribosylation factor like GTPase 2 binding protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT698204 | TMEM248 | transmembrane protein 248 | ![]() |
![]() |
2 | 2 | ||||||
MIRT703316 | GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT709376 | FAM13A | family with sequence similarity 13 member A | ![]() |
![]() |
2 | 2 | ||||||
MIRT710112 | MED23 | mediator complex subunit 23 | ![]() |
![]() |
2 | 2 | ||||||
MIRT711975 | HOMER2 | homer scaffolding protein 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT712275 | PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT714108 | TMED9 | transmembrane p24 trafficking protein 9 | ![]() |
![]() |
2 | 2 | ||||||
MIRT719113 | MAML1 | mastermind like transcriptional coactivator 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT719727 | SLC39A11 | solute carrier family 39 member 11 | ![]() |
![]() |
2 | 2 | ||||||
MIRT720018 | TFAP2C | transcription factor AP-2 gamma | ![]() |
![]() |
2 | 2 | ||||||
MIRT720358 | ZBTB8B | zinc finger and BTB domain containing 8B | ![]() |
![]() |
2 | 2 | ||||||
MIRT720372 | NUDT3 | nudix hydrolase 3 | ![]() |
![]() |
2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|