pre-miRNA Information | |
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pre-miRNA | hsa-mir-3189 |
Genomic Coordinates | chr19: 18386562 - 18386634 |
Description | Homo sapiens miR-3189 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-3189-5p | |||||||||||||||||||||
Sequence | 9| UGCCCCAUCUGUGCCCUGGGUAGGA |33 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | METTL24 | ||||||||||||||||||||
Synonyms | C6orf186, dJ71D21.2 | ||||||||||||||||||||
Description | methyltransferase like 24 | ||||||||||||||||||||
Transcript | NM_001123364 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on METTL24 | |||||||||||||||||||||
3'UTR of METTL24 (miRNA target sites are highlighted) |
>METTL24|NM_001123364|3'UTR 1 GATGCAGGATGTCATCAAGAGCACAAGAAAATATTTGCAGAATGCAGCATGTCCATAATTCTAATCATGAGTTTACTCAT 81 CCAGTCTCCTGCTAGCCTGTGCCCTGCTTGAGGCAGGGAGTGTGTTATTGCGGGCATGCAGCCTAGTGCTTGGCATGTGA 161 TGGGGCACAGTCAATACTTGTTAAAGGGATAAACACAGTCACCCCTATTTGCCCAGACTCTTCCTTCACCTTAACTTGGA 241 AGATTATCCCCAGCTCATCACAGTTTTCCCTAAAATTCTCTATGTATCTATAATCTATGAATTCACCAACATTGAAATGA 321 AATTATATAAATTTCCTATTTTTACTAGGTTGGTGAGATTTTTAAGTTCTTCCCCTACTGTTTAAAATAGGGTTTTAAAT 401 TTGAATTTGACCCTCCTTTTTCAAGGTTTTTCTTATTTACCTTGTTAATGATATTCTTTACAACCTTGTAGATTTCAGTC 481 ATTCCTTCTCAGCCTTTGCTGAGGCCATGCTGTGGCTTTCTAAGCAGCAATACTTCTGATTTCTGGGAACTCGGATGCAC 561 CAAATTCTGTCACTGAGTTAAAGAGACTAGACTATCAAGAGCTTCAACACGAAGGTGTAAGTTCCAGTTCGAGACCAAGT 641 CTGAAGGTCTTGACCTCACCAAGACCCATGTCCCAGCTTGAAGACAGCCAGACAGAGAATTAATTCTTCCTTACTGCCTT 721 AGGTTCTATTCAGGCCTTCAACTGGTTGAATGAGGTCCACTTACACTGAGGTGAAGAATCTGATTTATTTAGTCTACTGA 801 TTTAAATATTAATTTCATCTGGAAATATCCTTACAGATACACCTAGAATAATGTTTAACTAAAGATCTGGACACCCTTTA 881 GTCCAGTTAAGTTGACACATAAAATTAACCATTGTAGGTAGGTAGGTAGATAAATAGATAGATGATAGATAGATAGATAG 961 ATAGATAGATAGATAAGATAGATTTTCCTACTGGCATGTTTCACCATTTTCTTGACTCACATATTCTGGTTTCCATCTGG 1041 CTCCTTCGGTCTGTGCTCTCCTCACTGAAGTAAGGCCTTTAATGATTACTTCATTATAAGTCCATGAGTAATATGGTTTG 1121 GCTACGTCCCCAACCAAATCTCATCTTGAATTGTAGTTCCCATAATCCCCACGTGTTGTGGGAGGGACCTGGTGAGAGGT 1201 AATTGAATCATGGGGTTGGTTTCCTCCATGCTATTCTCATGATACTGAGTAAGTTCTCATGAGATCTGATGGTTTTATAA 1281 GAGGTGTCCCCCTTCACTTGGCTCTCATTTTTCTCCTTCCTGCTGCCATATGAAGAAGGATGTGTTTGCTTCCCCTTCCA 1361 CCACGACTGTAAGTTTCCTGAGGCCTCGCCAGCCATGCTAAACTGTGAGTCAATTAAATCTCTTTCCTCTATAAATTACT 1441 CAGTCTCAGGTATATCTTCATAGCAGTGTGAGAATGGACTAATACTTTGGGTATTACACTTTTTAGATTTTACGTATTTG 1521 AAAAAGCACTTGCTTTTTATACCTGAATAAAGTTTATTTGTTCACAGAAAAAAAAAAGAGCTTCAACTCAAGATGCTTTT 1601 TATACTCAGCCTTAATTCCCCTTCACTTCCTATTAAACTAAGCACAGAGCAGAATCTGGGTATCTTTGCTGTTGCCTCTT 1681 CTGCCTTCAAACATGATTTACCACCCACAGACTTGCCTATGCTGTCAAATCTTTTTTAAAAAAATACATTATCTCTAATA 1761 ATGTTAAGTGCATTTTTCTTTACTCCCAGTTGGCATCACTTACATGATTGTGGCCTGAAGACCATCGTCTCACTTTCGTA 1841 GGATAGTTAGACAGTTTTTCAATAGCACCGATCCTTTCTACATTAAAAGTTAAGTGGAAAGTTTAGGTTCTCAGCGGTTC 1921 AAATGCTCTCTCTCATTACTATTTACAGGATTAAACACGTGCATAATTTTCTAAAATTCTATTTCAAATAAATAGCATAA 2001 AAACCACATTATTACTTTATTGTCAATTAAATATATTTTTTGGCATTTTTA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | LCL-BAC-D2 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM1133252. RNA binding protein: AGO2. Condition:Untreated
... - Majoros WH; Lekprasert P; Mukherjee N; et al., 2013, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Majoros WH; Lekprasert P; Mukherjee N; et al. - Nature methods, 2013
High-throughput sequencing has opened numerous possibilities for the identification of regulatory RNA-binding events. Cross-linking and immunoprecipitation of Argonaute proteins can pinpoint a microRNA (miRNA) target site within tens of bases but leaves the identity of the miRNA unresolved. A flexible computational framework, microMUMMIE, integrates sequence with cross-linking features and reliably identifies the miRNA family involved in each binding event. It considerably outperforms sequence-only approaches and quantifies the prevalence of noncanonical binding modes.
LinkOut: [PMID: 23708386]
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CLIP-seq Support 1 for dataset GSM1133252 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | LCL-BAC-D2 / Untreated |
Location of target site | ENST00000338882.4 | 3UTR | UUGGCAUGUGAUGGGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23708386 / GSE46611 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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54 hsa-miR-3189-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT055405 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | 2 | 6 | ||||||||
MIRT263576 | GHITM | growth hormone inducible transmembrane protein | 2 | 2 | ||||||||
MIRT338983 | CPSF6 | cleavage and polyadenylation specific factor 6 | 2 | 2 | ||||||||
MIRT404222 | RPL7L1 | ribosomal protein L7 like 1 | 2 | 2 | ||||||||
MIRT451745 | CES3 | carboxylesterase 3 | 2 | 2 | ||||||||
MIRT454466 | RBM14 | RNA binding motif protein 14 | 2 | 8 | ||||||||
MIRT477627 | EFNA1 | ephrin A1 | 2 | 2 | ||||||||
MIRT495128 | METTL24 | methyltransferase like 24 | 2 | 2 | ||||||||
MIRT496506 | G6PC | glucose-6-phosphatase catalytic subunit | 2 | 2 | ||||||||
MIRT497260 | GRK6 | G protein-coupled receptor kinase 6 | 2 | 2 | ||||||||
MIRT501881 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2 | 2 | ||||||||
MIRT504586 | ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 2 | 4 | ||||||||
MIRT505570 | SMC1A | structural maintenance of chromosomes 1A | 2 | 6 | ||||||||
MIRT506759 | KMT2D | lysine methyltransferase 2D | 2 | 2 | ||||||||
MIRT512454 | POLR3G | RNA polymerase III subunit G | 2 | 2 | ||||||||
MIRT512716 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | 2 | 2 | ||||||||
MIRT514382 | CLUAP1 | clusterin associated protein 1 | 2 | 2 | ||||||||
MIRT519861 | ZFP62 | ZFP62 zinc finger protein | 2 | 6 | ||||||||
MIRT525670 | NHLRC4 | NHL repeat containing 4 | 2 | 2 | ||||||||
MIRT526359 | TIMMDC1 | translocase of inner mitochondrial membrane domain containing 1 | 2 | 2 | ||||||||
MIRT526656 | PRSS42 | protease, serine 42 | 2 | 4 | ||||||||
MIRT527017 | PABPN1L | poly(A) binding protein nuclear 1 like, cytoplasmic | 2 | 2 | ||||||||
MIRT532190 | MPDU1 | mannose-P-dolichol utilization defect 1 | 2 | 2 | ||||||||
MIRT533223 | VPS4A | vacuolar protein sorting 4 homolog A | 2 | 2 | ||||||||
MIRT543161 | GTF2A1 | general transcription factor IIA subunit 1 | 2 | 2 | ||||||||
MIRT552228 | SART3 | squamous cell carcinoma antigen recognized by T-cells 3 | 2 | 2 | ||||||||
MIRT552719 | YTHDC1 | YTH domain containing 1 | 2 | 2 | ||||||||
MIRT556873 | IVNS1ABP | influenza virus NS1A binding protein | 2 | 2 | ||||||||
MIRT558255 | DYNLL2 | dynein light chain LC8-type 2 | 2 | 2 | ||||||||
MIRT563105 | IFRD2 | interferon related developmental regulator 2 | 2 | 2 | ||||||||
MIRT565436 | SURF4 | surfeit 4 | 2 | 2 | ||||||||
MIRT568459 | ARPP19 | cAMP regulated phosphoprotein 19 | 2 | 2 | ||||||||
MIRT572804 | PPP3CB | protein phosphatase 3 catalytic subunit beta | 2 | 2 | ||||||||
MIRT576203 | Baz2a | bromodomain adjacent to zinc finger domain, 2A | 2 | 2 | ||||||||
MIRT623519 | KCNK10 | potassium two pore domain channel subfamily K member 10 | 2 | 2 | ||||||||
MIRT637006 | HHAT | hedgehog acyltransferase | 2 | 2 | ||||||||
MIRT643668 | WDR5 | WD repeat domain 5 | 2 | 2 | ||||||||
MIRT647472 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | 2 | 2 | ||||||||
MIRT650823 | LZTR1 | leucine zipper like transcription regulator 1 | 2 | 2 | ||||||||
MIRT657377 | HMGA1 | high mobility group AT-hook 1 | 2 | 2 | ||||||||
MIRT685077 | HPSE | heparanase | 2 | 2 | ||||||||
MIRT687565 | MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 | 2 | 2 | ||||||||
MIRT696101 | SETD1A | SET domain containing 1A | 2 | 2 | ||||||||
MIRT704887 | CCND1 | cyclin D1 | 2 | 2 | ||||||||
MIRT709133 | GLG1 | golgi glycoprotein 1 | 2 | 2 | ||||||||
MIRT709189 | SAPCD2 | suppressor APC domain containing 2 | 2 | 2 | ||||||||
MIRT713407 | PEX16 | peroxisomal biogenesis factor 16 | 2 | 2 | ||||||||
MIRT713467 | SLC22A12 | solute carrier family 22 member 12 | 2 | 2 | ||||||||
MIRT714544 | COL14A1 | collagen type XIV alpha 1 chain | 2 | 2 | ||||||||
MIRT716953 | TFAP2B | transcription factor AP-2 beta | 2 | 2 | ||||||||
MIRT717325 | PGK1 | phosphoglycerate kinase 1 | 2 | 2 | ||||||||
MIRT718252 | ZDHHC8 | zinc finger DHHC-type containing 8 | 2 | 2 | ||||||||
MIRT718522 | WDR33 | WD repeat domain 33 | 2 | 2 | ||||||||
MIRT723002 | FADS1 | fatty acid desaturase 1 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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