ID	Duplex structure	Position	Score	MFE
1	miRNA 3' ucgUCCU-CCCGAC----CCGUCCGc 5' |||| | ||| | ||||| Target 5' tcaAGGATGCACTGTATAGCCAGGCt 3'	103 - 128	120.00	-10.10
2	miRNA 3' ucguccucccgaCCCGUCCgc 5' ||| ||| Target 5' ---acttctataGGGAAGGgt 3'	1 - 18	93.00	-11.10
3	miRNA 3' ucguccucccgaccCGUCCGc 5' |::||| Target 5' agcatattgctgctGTGGGCt 3'	76 - 96	88.00	-10.20

Mutant ID	Mutant Position	Mutant Source
770239	606	ClinVar
COSN30106212	27	COSMIC
COSN30147254	29	COSMIC
COSN31598855	80	COSMIC
COSN30170040	104	COSMIC
COSN30105999	132	COSMIC
COSN21438665	184	COSMIC
COSN31564897	238	COSMIC
COSN30119142	252	COSMIC
COSN31516087	283	COSMIC
COSN26562130	376	COSMIC
COSN31582070	407	COSMIC
COSN30155497	417	COSMIC
COSN30481705	427	COSMIC
COSN30504588	451	COSMIC
COSN31531810	456	COSMIC
COSN31502143	462	COSMIC
COSN30146111	464	COSMIC
COSM7585523	471	COSMIC
COSM9530161	472	COSMIC
COSM6233197	478	COSMIC
COSM4247341	480	COSMIC
COSM7841355	481	COSMIC
COSM1370709	486	COSMIC
COSM7356111	502	COSMIC
COSM4456680	512	COSMIC
COSM8062115	550	COSMIC
COSM2135024	576	COSMIC
COSM4414302	578	COSMIC
COSM6353841	581	COSMIC
COSM9615396	607	COSMIC
COSM7181529	614	COSMIC
COSM8492934	622	COSMIC
COSM433274	640	COSMIC
COSM6345450	647	COSMIC
COSM7650050	661	COSMIC
COSM3886256	669	COSMIC
COSM8452354	669	COSMIC
COSM7203676	671	COSMIC
COSN164710	681	COSMIC
COSN9089130	2727	COSMIC
COSN29855329	2826	COSMIC
COSM3497274	3217	COSMIC
COSM9021761	3218	COSMIC
COSM8949807	3229	COSMIC
COSM5622553	3231	COSMIC
COSM957205	3240	COSMIC
COSM5054061	3256	COSMIC
COSM9886347	3259	COSMIC
COSM7794996	3272	COSMIC
COSM9182253	3277	COSMIC
COSM8172523	3307	COSMIC
COSM6538141	3323	COSMIC
COSN30629501	3399	COSMIC
COSN28838658	3434	COSMIC
COSN20049853	3439	COSMIC
COSN6638308	4041	COSMIC
COSN5172125	4084	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs1325408558	2	dbSNP
rs771831049	3	dbSNP
rs1343511613	5	dbSNP
rs1224131610	8	dbSNP
rs1384022632	9	dbSNP
rs1307485424	11	dbSNP
rs750935120	12	dbSNP
rs374547962	13	dbSNP
rs1261326944	14	dbSNP
rs113373898	16	dbSNP
rs755602822	19	dbSNP
rs1185633320	22	dbSNP
rs1289296061	24	dbSNP
rs1325836316	25	dbSNP
rs752300059	28	dbSNP
rs571839108	32	dbSNP
rs944299538	34	dbSNP
rs759327698	39	dbSNP
rs774272882	42	dbSNP
rs953171860	46	dbSNP
rs1205964236	53	dbSNP
rs1309396886	54	dbSNP
rs766287203	57	dbSNP
rs745701455	58	dbSNP
rs762913933	61	dbSNP
rs769859693	63	dbSNP
rs1402958000	69	dbSNP
rs748150354	70	dbSNP
rs776840694	77	dbSNP
rs1251738291	79	dbSNP
rs768854931	85	dbSNP
rs553543892	88	dbSNP
rs1169278400	96	dbSNP
rs773999577	100	dbSNP
rs1196911965	105	dbSNP
rs1430775320	111	dbSNP
rs1469803432	113	dbSNP
rs963163963	114	dbSNP
rs1232570407	116	dbSNP
rs992336541	122	dbSNP
rs1014740806	147	dbSNP
rs1352639119	155	dbSNP
rs577825661	164	dbSNP
rs201093539	177	dbSNP
rs190226837	178	dbSNP
rs140554394	180	dbSNP
rs375400078	180	dbSNP
rs1281539557	186	dbSNP
rs1347637960	192	dbSNP
rs1001669881	202	dbSNP
rs1395508951	206	dbSNP
rs1004687117	209	dbSNP
rs970594572	211	dbSNP
rs1257541138	214	dbSNP
rs1297816084	219	dbSNP
rs963535038	227	dbSNP
rs1025313537	230	dbSNP
rs1252238943	237	dbSNP
rs1012215252	242	dbSNP
rs1005126824	245	dbSNP
rs781177424	247	dbSNP
rs1053870985	250	dbSNP
rs886464288	251	dbSNP
rs1270515245	254	dbSNP
rs1000971957	261	dbSNP
rs902668423	268	dbSNP
rs567752051	283	dbSNP
rs757327436	285	dbSNP
rs549257292	297	dbSNP
rs534640426	300	dbSNP
rs537036611	307	dbSNP
rs944192063	313	dbSNP
rs1304755741	316	dbSNP
rs1190718122	319	dbSNP
rs1424692921	325	dbSNP
rs1250336765	329	dbSNP
rs569744591	333	dbSNP
rs1193704455	341	dbSNP
rs912781805	342	dbSNP
rs1216824769	343	dbSNP
rs1296832225	345	dbSNP
rs1321655219	354	dbSNP
rs1803452	359	dbSNP
rs1244174036	362	dbSNP
rs1294438811	384	dbSNP
rs1039282430	392	dbSNP
rs551234244	402	dbSNP
rs1239862035	407	dbSNP
rs1486525625	411	dbSNP
rs780331868	415	dbSNP
rs1202059933	416	dbSNP
rs936558225	434	dbSNP
rs1356498547	435	dbSNP
rs376794861	436	dbSNP
rs1268794524	438	dbSNP
rs746326646	440	dbSNP
rs114217628	444	dbSNP
rs757822631	445	dbSNP
rs770910663	447	dbSNP
rs1204033514	450	dbSNP
rs369339972	451	dbSNP
rs1264697073	454	dbSNP
rs868624982	456	dbSNP
rs945269964	457	dbSNP
rs1425520932	458	dbSNP
rs866779708	458	dbSNP
rs780811499	465	dbSNP
rs1158403232	467	dbSNP
rs754618595	472	dbSNP
rs751258615	474	dbSNP
rs200608161	476	dbSNP
rs1293743970	477	dbSNP
rs762859411	478	dbSNP
rs112748595	479	dbSNP
rs1322328676	484	dbSNP
rs1173897584	487	dbSNP
rs959383754	490	dbSNP
rs761870615	496	dbSNP
rs141779491	497	dbSNP
rs1223588276	498	dbSNP
rs926430133	499	dbSNP
rs768729907	512	dbSNP
rs141432809	515	dbSNP
rs775712860	518	dbSNP
rs1176691930	521	dbSNP
rs1012617240	533	dbSNP
rs772330019	535	dbSNP
rs749110206	536	dbSNP
rs370005314	538	dbSNP
rs1243522412	541	dbSNP
rs375587822	542	dbSNP
rs1268566409	544	dbSNP
rs1241041022	547	dbSNP
rs781361038	550	dbSNP
rs185767649	551	dbSNP
rs771327205	555	dbSNP
rs749813786	556	dbSNP
rs780779961	557	dbSNP
rs1451095174	558	dbSNP
rs1339195925	559	dbSNP
rs759402808	564	dbSNP
rs1451499408	570	dbSNP
rs754563616	574	dbSNP
rs148319106	578	dbSNP
rs1487657718	579	dbSNP
rs753665555	582	dbSNP
rs1278177596	585	dbSNP
rs779826880	587	dbSNP
rs576083183	590	dbSNP
rs372329104	591	dbSNP
rs1375030765	600	dbSNP
rs1224044318	601	dbSNP
rs45584632	606	dbSNP
rs753847977	607	dbSNP
rs1030756780	608	dbSNP
rs1461059249	622	dbSNP
rs1248349851	625	dbSNP
rs764112987	634	dbSNP
rs1320879407	636	dbSNP
rs368075714	637	dbSNP
rs199503101	642	dbSNP
rs147982459	645	dbSNP
rs772276999	646	dbSNP
rs755000818	650	dbSNP
rs1360925540	654	dbSNP
rs181582499	656	dbSNP
rs1244713962	662	dbSNP
rs189159556	663	dbSNP
rs1319950798	665	dbSNP
rs1384258546	670	dbSNP
rs1383317245	674	dbSNP
rs10483802	681	dbSNP
rs747068143	684	dbSNP
rs1178064656	686	dbSNP
rs780294795	689	dbSNP
rs761391054	690	dbSNP
rs770469440	696	dbSNP
rs746483021	698	dbSNP
rs779773557	699	dbSNP
rs201273403	700	dbSNP
rs1260813067	706	dbSNP
rs1210308448	709	dbSNP
rs1490823944	713	dbSNP
rs745541391	715	dbSNP
rs758615579	721	dbSNP
rs1356700717	724	dbSNP
rs1210332336	727	dbSNP
rs945302666	728	dbSNP
rs1349917529	742	dbSNP
rs1282168515	747	dbSNP
rs932925754	749	dbSNP
rs1343266107	752	dbSNP
rs1224762028	755	dbSNP
rs898761834	761	dbSNP
rs574191752	769	dbSNP
rs917791907	770	dbSNP
rs1194052603	771	dbSNP
rs375317273	781	dbSNP
rs1258926980	785	dbSNP
rs1274856417	793	dbSNP
rs1240862262	797	dbSNP
rs1221485196	798	dbSNP
rs1268387506	802	dbSNP
rs1336146861	805	dbSNP
rs375026082	815	dbSNP
rs1430137497	816	dbSNP
rs941701615	821	dbSNP
rs1166726910	826	dbSNP
rs907595683	827	dbSNP
rs34922083	829	dbSNP
rs75700611	829	dbSNP
rs1368857812	831	dbSNP
rs1302943374	843	dbSNP
rs1328064727	854	dbSNP
rs1363286995	859	dbSNP
rs185690128	859	dbSNP
rs983197727	861	dbSNP
rs1406431726	865	dbSNP
rs949245578	873	dbSNP
rs1224620142	875	dbSNP
rs1271802782	877	dbSNP
rs917763797	878	dbSNP
rs1244927722	882	dbSNP
rs926267165	882	dbSNP
rs1225079175	897	dbSNP
rs1268139008	900	dbSNP
rs769287320	904	dbSNP
rs141331292	908	dbSNP
rs1375233162	910	dbSNP
rs1450670208	912	dbSNP
rs551371046	915	dbSNP
rs182321313	918	dbSNP
rs1452234574	925	dbSNP
rs1383810194	929	dbSNP
rs1379978900	932	dbSNP
rs1254298178	934	dbSNP
rs1198900625	938	dbSNP
rs1445942544	940	dbSNP
rs146609124	944	dbSNP
rs145848742	945	dbSNP
rs1361416395	947	dbSNP
rs1246440551	949	dbSNP
rs149005592	950	dbSNP
rs1354146660	960	dbSNP
rs1350253873	964	dbSNP
rs1279416722	968	dbSNP
rs766178462	969	dbSNP
rs1203420930	971	dbSNP
rs1233812906	977	dbSNP
rs1465725969	980	dbSNP
rs1346043597	1004	dbSNP
rs118014660	1018	dbSNP
rs34039060	1023	dbSNP
rs1008342797	1036	dbSNP
rs189413149	1041	dbSNP
rs531447552	1042	dbSNP
rs1362819219	1059	dbSNP
rs564027459	1061	dbSNP
rs1451234342	1064	dbSNP
rs1159774386	1070	dbSNP
rs976733905	1087	dbSNP
rs10483801	1096	dbSNP
rs1384920373	1097	dbSNP
rs1028882347	1103	dbSNP
rs1453032805	1106	dbSNP
rs571993257	1110	dbSNP
rs559985020	1112	dbSNP
rs903913654	1117	dbSNP
rs1020746309	1124	dbSNP
rs1361542686	1130	dbSNP
rs1330000228	1133	dbSNP
rs74058958	1134	dbSNP
rs1261763268	1140	dbSNP
rs1463077420	1142	dbSNP
rs1009392157	1154	dbSNP
rs1250320951	1161	dbSNP
rs541393407	1161	dbSNP
rs941691811	1164	dbSNP
rs886144436	1165	dbSNP
rs757365717	1166	dbSNP
rs1479789822	1177	dbSNP
rs904877064	1182	dbSNP
rs1466521300	1186	dbSNP
rs1038014727	1199	dbSNP
rs949184985	1203	dbSNP
rs574151321	1207	dbSNP
rs751643764	1208	dbSNP
rs1309351355	1214	dbSNP
rs941099846	1216	dbSNP
rs1222940179	1217	dbSNP
rs34970739	1221	dbSNP
rs937861016	1231	dbSNP
rs184485306	1235	dbSNP
rs1488605002	1242	dbSNP
rs1252022538	1250	dbSNP
rs1479921974	1264	dbSNP
rs1196606598	1272	dbSNP
rs1430853887	1280	dbSNP
rs1433688163	1284	dbSNP
rs753757545	1293	dbSNP
rs1256506594	1294	dbSNP
rs766130999	1295	dbSNP
rs1020998534	1296	dbSNP
rs191701268	1299	dbSNP
rs1371365803	1310	dbSNP
rs1404618821	1331	dbSNP
rs187250210	1332	dbSNP
rs1369909541	1333	dbSNP
rs965301227	1335	dbSNP
rs1295422909	1338	dbSNP
rs1306288888	1345	dbSNP
rs1017612447	1346	dbSNP
rs1490076972	1349	dbSNP
rs1338810612	1351	dbSNP
rs979361885	1371	dbSNP
rs1028411940	1376	dbSNP
rs997387643	1381	dbSNP
rs1220965271	1383	dbSNP
rs898696647	1389	dbSNP
rs1017138028	1391	dbSNP
rs1341635539	1410	dbSNP
rs1004444803	1416	dbSNP
rs1384446873	1423	dbSNP
rs539442013	1429	dbSNP
rs565976864	1430	dbSNP
rs1161835481	1435	dbSNP
rs554014689	1435	dbSNP
rs1312826408	1442	dbSNP
rs1437219751	1445	dbSNP
rs760517165	1447	dbSNP
rs1047354616	1452	dbSNP
rs1377659414	1459	dbSNP
rs1360449659	1461	dbSNP
rs184379708	1463	dbSNP
rs149874834	1466	dbSNP
rs528837005	1474	dbSNP
rs896341829	1485	dbSNP
rs1393665427	1487	dbSNP
rs1054918145	1505	dbSNP
rs1035244389	1508	dbSNP
rs937841828	1512	dbSNP
rs1169185618	1514	dbSNP
rs1258486130	1515	dbSNP
rs1002141347	1521	dbSNP
rs1189217848	1530	dbSNP
rs192169736	1541	dbSNP
rs905077675	1552	dbSNP
rs1416175535	1556	dbSNP
rs550008132	1559	dbSNP
rs1185715303	1578	dbSNP
rs1343566124	1584	dbSNP
rs767209425	1600	dbSNP
rs1382713009	1622	dbSNP
rs1450846756	1629	dbSNP
rs1237899538	1630	dbSNP
rs1379417239	1633	dbSNP
rs1211054384	1635	dbSNP
rs531384462	1638	dbSNP
rs1437499639	1643	dbSNP
rs761487135	1661	dbSNP
rs1271182680	1662	dbSNP
rs945247922	1664	dbSNP
rs774025142	1669	dbSNP
rs768231520	1670	dbSNP
rs561465262	1679	dbSNP
rs1459947884	1688	dbSNP
rs1205293058	1691	dbSNP
rs941045862	1701	dbSNP
rs1473239282	1708	dbSNP
rs570559059	1721	dbSNP
rs1176908019	1736	dbSNP
rs1318715989	1752	dbSNP
rs1293146191	1767	dbSNP
rs1232075603	1770	dbSNP
rs1473579539	1771	dbSNP
rs886766776	1775	dbSNP
rs8015333	1778	dbSNP
rs955410882	1779	dbSNP
rs1333584765	1785	dbSNP
rs139056063	1788	dbSNP
rs1465628057	1794	dbSNP
rs113591899	1802	dbSNP
rs1277353892	1807	dbSNP
rs1351975724	1808	dbSNP
rs1228432772	1809	dbSNP
rs943636389	1814	dbSNP
rs541677015	1823	dbSNP
rs962832259	1829	dbSNP
rs1017086119	1833	dbSNP
rs1004348414	1842	dbSNP
rs757581690	1848	dbSNP
rs529570404	1849	dbSNP
rs1414208589	1868	dbSNP
rs1231344855	1872	dbSNP
rs951606072	1874	dbSNP
rs1182963680	1876	dbSNP
rs1428753626	1877	dbSNP
rs1479741477	1879	dbSNP
rs1176367695	1882	dbSNP
rs45462391	1887	dbSNP
rs1231333388	1888	dbSNP
rs781158857	1891	dbSNP
rs1409705433	1894	dbSNP
rs1180752559	1898	dbSNP
rs1327310487	1915	dbSNP
rs1371984419	1920	dbSNP
rs775526901	1922	dbSNP
rs896194597	1945	dbSNP
rs530989105	1950	dbSNP
rs1212346960	1956	dbSNP
rs144324015	1966	dbSNP
rs988201460	1969	dbSNP
rs961048990	1970	dbSNP
rs1338690573	1972	dbSNP
rs1055267448	1980	dbSNP
rs1001990794	1988	dbSNP
rs1034869512	1989	dbSNP
rs1206223369	1990	dbSNP
rs746260631	1992	dbSNP
rs1002410209	2003	dbSNP
rs1449882034	2009	dbSNP
rs1310993561	2010	dbSNP
rs969246998	2012	dbSNP
rs1247763826	2016	dbSNP
rs1475399488	2020	dbSNP
rs1043556396	2034	dbSNP
rs1005460295	2038	dbSNP
rs576272590	2040	dbSNP
rs945195021	2041	dbSNP
rs913788084	2042	dbSNP
rs886799452	2043	dbSNP
rs1387954394	2044	dbSNP
rs1323680575	2046	dbSNP
rs370773416	2054	dbSNP
rs1323351786	2056	dbSNP
rs1365574028	2057	dbSNP
rs1438023942	2064	dbSNP
rs1350346254	2066	dbSNP
rs1354551765	2074	dbSNP
rs1211687384	2076	dbSNP
rs1290736519	2082	dbSNP
rs771175047	2085	dbSNP
rs1187298947	2088	dbSNP
rs546011056	2089	dbSNP
rs1450414251	2095	dbSNP
rs921295965	2096	dbSNP
rs1039452062	2098	dbSNP
rs1366310484	2113	dbSNP
rs1459158100	2115	dbSNP
rs1398671652	2130	dbSNP
rs1163318931	2140	dbSNP
rs1383699434	2143	dbSNP
rs1398458710	2148	dbSNP
rs1322396406	2151	dbSNP
rs1365872723	2159	dbSNP
rs943564821	2161	dbSNP
rs1312705074	2165	dbSNP
rs975887947	2172	dbSNP
rs1382017191	2180	dbSNP
rs962739209	2181	dbSNP
rs1338908261	2187	dbSNP
rs1247326064	2189	dbSNP
rs1284845683	2196	dbSNP
rs1349960484	2205	dbSNP
rs1206915822	2209	dbSNP
rs1270522551	2213	dbSNP
rs1288431166	2221	dbSNP
rs1465768416	2222	dbSNP
rs909988166	2230	dbSNP
rs572375568	2233	dbSNP
rs951555748	2247	dbSNP
rs796970491	2252	dbSNP
rs1362878782	2258	dbSNP
rs1014532973	2261	dbSNP
rs1043977722	2266	dbSNP
rs960638920	2279	dbSNP
rs913919437	2282	dbSNP
rs553893164	2294	dbSNP
rs535697302	2295	dbSNP
rs1334427781	2305	dbSNP
rs1404163272	2313	dbSNP
rs1396394673	2314	dbSNP
rs1335027137	2319	dbSNP
rs1033322186	2327	dbSNP
rs1489519948	2328	dbSNP
rs1335420377	2334	dbSNP
rs988515380	2340	dbSNP
rs568363366	2346	dbSNP
rs1001890628	2347	dbSNP
rs747186127	2348	dbSNP
rs928080035	2352	dbSNP
rs140464466	2355	dbSNP
rs147193750	2359	dbSNP
rs1183693350	2366	dbSNP
rs892342672	2373	dbSNP
rs1480064445	2377	dbSNP
rs1173781347	2382	dbSNP
rs1423086573	2388	dbSNP
rs777884934	2395	dbSNP
rs1346651085	2396	dbSNP
rs933950699	2405	dbSNP
rs899757689	2407	dbSNP
rs1039684195	2408	dbSNP
rs1025317091	2412	dbSNP
rs998298384	2414	dbSNP
rs1404425916	2417	dbSNP
rs900828654	2418	dbSNP
rs1018467933	2424	dbSNP
rs1006621317	2426	dbSNP
rs889299055	2430	dbSNP
rs1288215426	2433	dbSNP
rs758445236	2437	dbSNP
rs1339623869	2441	dbSNP
rs184021784	2444	dbSNP
rs1362199729	2446	dbSNP
rs780025598	2452	dbSNP
rs1490026222	2454	dbSNP
rs892682163	2457	dbSNP
rs909935385	2458	dbSNP
rs1052701171	2470	dbSNP
rs982861980	2474	dbSNP
rs930127819	2475	dbSNP
rs917454485	2476	dbSNP
rs1170655771	2479	dbSNP
rs1371428456	2481	dbSNP
rs993418781	2483	dbSNP
rs1291903585	2489	dbSNP
rs192079049	2490	dbSNP
rs1035020169	2492	dbSNP
rs879589285	2518	dbSNP
rs1297318905	2529	dbSNP
rs980401766	2533	dbSNP
rs981288715	2535	dbSNP
rs545045554	2539	dbSNP
rs1434916542	2541	dbSNP
rs1358323110	2556	dbSNP
rs909723375	2557	dbSNP
rs1488758483	2567	dbSNP
rs1186420317	2576	dbSNP
rs1246130142	2580	dbSNP
rs1485200778	2581	dbSNP
rs1266009293	2600	dbSNP
rs1217737042	2613	dbSNP
rs1390987813	2623	dbSNP
rs12884807	2626	dbSNP
rs566424339	2633	dbSNP
rs951191555	2638	dbSNP
rs1351760492	2642	dbSNP
rs11622441	2643	dbSNP
rs892279286	2649	dbSNP
rs751233829	2654	dbSNP
rs1029466889	2655	dbSNP
rs575447038	2663	dbSNP
rs998445441	2666	dbSNP
rs899709182	2670	dbSNP
rs976682041	2675	dbSNP
rs1298850504	2679	dbSNP
rs965439139	2680	dbSNP
rs1039604343	2692	dbSNP
rs142641239	2694	dbSNP
rs1278791277	2704	dbSNP
rs1321736897	2708	dbSNP
rs562038895	2711	dbSNP
rs1017913685	2721	dbSNP
rs1007063600	2739	dbSNP
rs1301300981	2740	dbSNP
rs1209100115	2742	dbSNP
rs543743323	2747	dbSNP
rs1047123800	2754	dbSNP
rs1242363123	2759	dbSNP
rs1467817380	2763	dbSNP
rs763736305	2773	dbSNP
rs1180273599	2775	dbSNP
rs1169777259	2778	dbSNP
rs1416243085	2783	dbSNP
rs187788091	2784	dbSNP
rs1476893106	2793	dbSNP
rs992974327	2795	dbSNP
rs1410354315	2798	dbSNP
rs937516302	2801	dbSNP
rs927562195	2807	dbSNP
rs892629951	2809	dbSNP
rs979049810	2814	dbSNP
rs1379483752	2817	dbSNP
rs1227214038	2828	dbSNP
rs182278932	2838	dbSNP
rs939601152	2840	dbSNP
rs1229003521	2846	dbSNP
rs1277841530	2858	dbSNP
rs906547180	2866	dbSNP
rs1045045715	2871	dbSNP
rs1239388228	2873	dbSNP
rs948119493	2873	dbSNP
rs1021996715	2874	dbSNP
rs36217347	2883	dbSNP
rs375608909	2883	dbSNP
rs774806055	2889	dbSNP
rs984196501	2891	dbSNP
rs1201798838	2907	dbSNP
rs546242682	2920	dbSNP
rs929823289	2923	dbSNP
rs1425110734	2928	dbSNP
rs1413083525	2930	dbSNP
rs1483398249	2934	dbSNP
rs8010798	2935	dbSNP
rs1359360393	2937	dbSNP
rs1408904208	2945	dbSNP
rs977091206	2945	dbSNP
rs1201764672	2948	dbSNP
rs965293959	2953	dbSNP
rs1018364529	2954	dbSNP
rs1342827934	2958	dbSNP
rs543228316	2958	dbSNP
rs1279129192	2962	dbSNP
rs956457836	2967	dbSNP
rs1249895755	2969	dbSNP
rs1029828956	2988	dbSNP
rs759921355	2992	dbSNP
rs997994846	3005	dbSNP
rs372340047	3008	dbSNP
rs1246604188	3013	dbSNP
rs777077650	3014	dbSNP
rs541852483	3021	dbSNP
rs1005455032	3023	dbSNP
rs1193270604	3027	dbSNP
rs1426392464	3039	dbSNP
rs1314657211	3040	dbSNP
rs189983478	3045	dbSNP
rs746563071	3046	dbSNP
rs1372042024	3048	dbSNP
rs1380099134	3054	dbSNP
rs35508499	3061	dbSNP
rs994578394	3062	dbSNP
rs1329256708	3068	dbSNP
rs895868696	3074	dbSNP
rs1275216204	3075	dbSNP
rs1364108257	3089	dbSNP
rs1057471699	3092	dbSNP
rs937524116	3097	dbSNP
rs1402629244	3100	dbSNP
rs3742879	3101	dbSNP
rs1344629606	3102	dbSNP
rs1461425916	3102	dbSNP
rs773420258	3102	dbSNP
rs1367058754	3104	dbSNP
rs1450388348	3107	dbSNP
rs1190008126	3114	dbSNP
rs1028424769	3115	dbSNP
rs888436207	3121	dbSNP
rs1187106281	3143	dbSNP
rs1048530926	3150	dbSNP
rs778534550	3151	dbSNP
rs1449753069	3152	dbSNP
rs753682357	3154	dbSNP
rs1388035244	3155	dbSNP
rs771219537	3156	dbSNP
rs1325011705	3165	dbSNP
rs763987669	3167	dbSNP
rs1406606687	3170	dbSNP
rs1406030785	3173	dbSNP
rs201696913	3180	dbSNP
rs765464196	3184	dbSNP
rs202104783	3186	dbSNP
rs558483667	3190	dbSNP
rs374223197	3198	dbSNP
rs1361815388	3208	dbSNP
rs1367601967	3209	dbSNP
rs1169829130	3210	dbSNP
rs918426891	3213	dbSNP
rs1460677359	3221	dbSNP
rs1283820389	3229	dbSNP
rs757789815	3230	dbSNP
rs1199887158	3235	dbSNP
rs371149374	3240	dbSNP
rs754262476	3247	dbSNP
rs1354263180	3252	dbSNP
rs376070237	3256	dbSNP
rs146923741	3257	dbSNP
rs770414556	3258	dbSNP
rs141107940	3261	dbSNP
rs1464876692	3265	dbSNP
rs775076365	3267	dbSNP
rs1207196762	3270	dbSNP
rs1250358430	3272	dbSNP
rs1251048958	3277	dbSNP
rs771646335	3278	dbSNP
rs745464169	3281	dbSNP
rs911182489	3282	dbSNP
rs1404926253	3283	dbSNP
rs1336372870	3284	dbSNP
rs778606810	3286	dbSNP
rs756900951	3291	dbSNP
rs749077701	3293	dbSNP
rs1411117956	3299	dbSNP
rs987766282	3300	dbSNP
rs1177494953	3303	dbSNP
rs777602887	3306	dbSNP
rs755986438	3310	dbSNP
rs752635343	3316	dbSNP
rs1389015998	3317	dbSNP
rs767453282	3318	dbSNP
rs755104943	3319	dbSNP
rs751636666	3320	dbSNP
rs1436788358	3323	dbSNP
rs766589780	3329	dbSNP
rs748270121	3332	dbSNP
rs778789921	3334	dbSNP
rs1326066930	3338	dbSNP
rs1261684074	3340	dbSNP
rs1247049546	3345	dbSNP
rs1005360128	3352	dbSNP
rs765705002	3353	dbSNP
rs762374024	3359	dbSNP
rs763722348	3363	dbSNP
rs777301964	3365	dbSNP
rs1337600323	3375	dbSNP
rs1469401058	3377	dbSNP
rs760313587	3382	dbSNP
rs756103833	3389	dbSNP
rs971294664	3393	dbSNP
rs1025526653	3401	dbSNP
rs1316120906	3404	dbSNP
rs185493183	3412	dbSNP
rs888464364	3420	dbSNP
rs566442009	3428	dbSNP
rs1471325620	3431	dbSNP
rs36098177	3433	dbSNP
rs1161208675	3438	dbSNP
rs895846501	3439	dbSNP
rs1465322770	3441	dbSNP
rs548306614	3448	dbSNP
rs1170632007	3458	dbSNP
rs1400312420	3460	dbSNP
rs750021775	3462	dbSNP
rs1313557431	3472	dbSNP
rs1057200860	3484	dbSNP
rs1440307586	3506	dbSNP
rs181364322	3512	dbSNP
rs745739391	3514	dbSNP
rs1318080677	3518	dbSNP
rs994259497	3518	dbSNP
rs1254685783	3530	dbSNP
rs1002052259	3541	dbSNP
rs1211070945	3545	dbSNP
rs781181111	3550	dbSNP
rs1043222256	3553	dbSNP
rs1481756837	3555	dbSNP
rs1458673312	3574	dbSNP
rs1183751334	3579	dbSNP
rs1251110545	3580	dbSNP
rs1363653987	3581	dbSNP
rs757087703	3588	dbSNP
rs539191345	3594	dbSNP
rs751321815	3595	dbSNP
rs1379222689	3605	dbSNP
rs1435112119	3605	dbSNP
rs947536540	3609	dbSNP
rs1441204787	3610	dbSNP
rs913452717	3621	dbSNP
rs1427858144	3623	dbSNP
rs911034632	3626	dbSNP
rs1374672728	3627	dbSNP
rs1386772967	3635	dbSNP
rs1299822870	3644	dbSNP
rs1053813759	3647	dbSNP
rs1269292508	3649	dbSNP
rs1235503555	3653	dbSNP
rs372900792	3659	dbSNP
rs1210428297	3662	dbSNP
rs1339679660	3670	dbSNP
rs935009302	3676	dbSNP
rs922283560	3685	dbSNP
rs976459689	3687	dbSNP
rs942421255	3689	dbSNP
rs914254076	3691	dbSNP
rs1283684009	3699	dbSNP
rs910974024	3704	dbSNP
rs1454515138	3716	dbSNP
rs1238208636	3720	dbSNP
rs988404440	3727	dbSNP
rs191817316	3732	dbSNP
rs955894447	3736	dbSNP
rs983885875	3738	dbSNP
rs1233590509	3751	dbSNP
rs928436266	3752	dbSNP
rs1355118736	3753	dbSNP
rs1457480052	3758	dbSNP
rs952584569	3767	dbSNP
rs1025516629	3768	dbSNP
rs1387921349	3775	dbSNP
rs1442052663	3777	dbSNP
rs1384657446	3798	dbSNP
rs1362569472	3807	dbSNP
rs973085605	3818	dbSNP
rs960057467	3820	dbSNP
rs763823125	3831	dbSNP
rs758058845	3834	dbSNP
rs1295856174	3836	dbSNP
rs550138544	3837	dbSNP
rs970941196	3838	dbSNP
rs905905432	3840	dbSNP
rs1021725786	3841	dbSNP
rs752285422	3846	dbSNP
rs1207856470	3848	dbSNP
rs892007056	3858	dbSNP
rs1053355276	3863	dbSNP
rs1246036020	3878	dbSNP
rs1230061904	3885	dbSNP
rs933540867	3886	dbSNP
rs531896792	3890	dbSNP
rs1188444237	3891	dbSNP
rs1420519579	3894	dbSNP
rs952905497	3898	dbSNP
rs902112500	3899	dbSNP
rs1041071339	3910	dbSNP
rs1260982417	3918	dbSNP
rs1462478641	3922	dbSNP
rs942379218	3923	dbSNP
rs553778415	3927	dbSNP
rs1026989500	3929	dbSNP
rs1218458758	3932	dbSNP
rs983877716	3934	dbSNP
rs931131583	3938	dbSNP
rs918450091	3942	dbSNP
rs1378033601	3945	dbSNP
rs1393759635	3948	dbSNP
rs972603707	3955	dbSNP
rs1335386840	3964	dbSNP
rs1227640869	3965	dbSNP
rs1488502335	3971	dbSNP
rs897141027	3974	dbSNP
rs1286931574	3989	dbSNP
rs764602857	3993	dbSNP
rs1216270347	4005	dbSNP
rs1242882948	4007	dbSNP
rs960204027	4021	dbSNP
rs1200164750	4035	dbSNP
rs564299047	4051	dbSNP
rs186933623	4066	dbSNP
rs1475581504	4076	dbSNP
rs527930454	4089	dbSNP
rs1159005886	4096	dbSNP
rs1410433740	4097	dbSNP
rs1402763665	4101	dbSNP
rs1276740537	4114	dbSNP
rs1160343367	4117	dbSNP
rs1358195525	4121	dbSNP
rs1464283859	4124	dbSNP
rs182319313	4126	dbSNP
rs980474730	4137	dbSNP
rs1234091255	4142	dbSNP
rs1286336904	4143	dbSNP
rs542343361	4147	dbSNP
rs1340397222	4150	dbSNP
rs1375492870	4156	dbSNP
rs1276866843	4160	dbSNP
rs61990126	4181	dbSNP
rs1306021019	4193	dbSNP
rs970080122	4200	dbSNP
rs574863109	4204	dbSNP
rs1361648766	4209	dbSNP
rs1295093293	4215	dbSNP
rs1311820676	4217	dbSNP
rs1208922770	4220	dbSNP
rs190496290	4223	dbSNP
rs1058584	4235	dbSNP
rs1049524273	4237	dbSNP
rs760139055	4240	dbSNP
rs1250210702	4243	dbSNP
rs867654375	4245	dbSNP
rs893018647	4250	dbSNP
rs533251976	4274	dbSNP
rs577213999	4280	dbSNP
rs373436709	4282	dbSNP
rs1195766452	4287	dbSNP
rs1424817491	4292	dbSNP
rs1441851657	4293	dbSNP
rs560257193	4293	dbSNP
rs902058986	4294	dbSNP
rs928268505	4296	dbSNP

- PLoS pathogens, 2012

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.