>EIF3H|NM_003756|3'UTR
   1 GAAAAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTGAAGTCACACCAGGGCAACTCTTGGAAGAAATATATTTGC
  81 ATATTGAAAAGCACAGAGGATTTCTTTAGTGTCATTGCCGATTTTGGCTATAACAGTGTCTTTCTAGCCATAATAAAATA
 161 AAACAAAATCTTGACTGCTTGCTCATTTGAAAAAAAAAAAA

ID	Duplex structure	Position	Score	MFE
1	miRNA 3' gagUGGACUCGA---GGGCACGGAc 5' |::| :||| | |||:|| Target 5' ccgATTTTGGCTATAACAGTGTCTt 3'	118 - 142	107.00	-10.40
2	miRNA 3' gaGUGGACUC-----GAGGGCACGGac 5' || | ||| ||:: |||:| Target 5' agCA-CAGAGGATTTCTTTAGTGTCat 3'	90 - 115	87.00	-10.90
3	miRNA 3' gaguGGACUCGAGGGCACGGac 5' |:||| || | |||: Target 5' aaatCTTGA-CT-GCTTGCTca 3'	166 - 185	84.00	-11.00

Mutant ID	Mutant Position	Mutant Source
COSN28885844	8	COSMIC
COSN30187480	27	COSMIC
COSN30619968	36	COSMIC
COSN31587129	38	COSMIC
COSN30505330	40	COSMIC
COSN30504464	52	COSMIC
COSN30478230	53	COSMIC
COSN30167574	61	COSMIC
COSN30472844	65	COSMIC
COSN31575467	104	COSMIC
COSN31532236	119	COSMIC
COSN30165942	130	COSMIC
COSN9592715	343	COSMIC
COSN8574482	423	COSMIC
COSN26663271	487	COSMIC
COSN32064258	491	COSMIC
COSN32209997	708	COSMIC
COSN5107929	764	COSMIC
COSN9253527	893	COSMIC
COSN16881411	981	COSMIC
COSN22537954	1014	COSMIC
COSN28202644	1130	COSMIC
COSN6908735	1169	COSMIC
COSN22404832	1412	COSMIC
COSN30009119	1667	COSMIC
COSN22829778	1720	COSMIC
COSN21821419	1900	COSMIC
COSN26663270	2337	COSMIC
COSN20731654	2420	COSMIC
COSN9592714	2483	COSMIC
COSN21723712	2504	COSMIC
COSN2257007	2615	COSMIC
COSN21210433	2786	COSMIC
rs2278491	374	GWAS

Mutant ID	Mutant Position	Mutant Source
rs1192896840	4	dbSNP
rs1487495292	7	dbSNP
rs1262448466	10	dbSNP
rs1215834715	13	dbSNP
rs1315820972	18	dbSNP
rs1283421050	20	dbSNP
rs755197292	22	dbSNP
rs1292911563	30	dbSNP
rs1804926	31	dbSNP
rs766468007	36	dbSNP
rs201877205	39	dbSNP
rs1210661830	41	dbSNP
rs1042450031	43	dbSNP
rs946774647	45	dbSNP
rs750379790	46	dbSNP
rs767331781	48	dbSNP
rs1804927	50	dbSNP
rs1257695519	53	dbSNP
rs1459773354	56	dbSNP
rs915358202	59	dbSNP
rs10054	64	dbSNP
rs561915323	66	dbSNP
rs1248843970	72	dbSNP
rs938167451	91	dbSNP
rs928134228	97	dbSNP
rs1186740229	104	dbSNP
rs11547847	114	dbSNP
rs1024595586	119	dbSNP
rs961647260	120	dbSNP
rs1232934056	130	dbSNP
rs1469593188	134	dbSNP
rs1321692720	135	dbSNP
rs1388917021	137	dbSNP
rs1436909994	140	dbSNP
rs1356118738	144	dbSNP
rs1455974846	144	dbSNP
rs1014918552	150	dbSNP
rs777946007	152	dbSNP
rs1336299687	159	dbSNP
rs1222664947	164	dbSNP
rs754973636	164	dbSNP
rs149867098	170	dbSNP
rs1466097680	173	dbSNP
rs908210909	178	dbSNP
rs1213825107	195	dbSNP
rs1241774492	212	dbSNP
rs558537841	214	dbSNP
rs546376281	215	dbSNP
rs535048447	216	dbSNP
rs1416154908	221	dbSNP
rs1160355907	229	dbSNP
rs749308405	230	dbSNP
rs575762148	231	dbSNP
rs1315744942	236	dbSNP
rs1005658090	239	dbSNP
rs997014005	240	dbSNP
rs888492156	243	dbSNP
rs1294841759	249	dbSNP
rs1342530937	252	dbSNP
rs758102659	256	dbSNP
rs965208317	259	dbSNP
rs1019463121	260	dbSNP
rs998767600	261	dbSNP
rs1189061678	263	dbSNP
rs1047100661	267	dbSNP
rs903135006	268	dbSNP
rs112554472	276	dbSNP
rs922590586	282	dbSNP
rs1322597340	297	dbSNP
rs1010930391	299	dbSNP
rs1490212023	305	dbSNP
rs1183453316	306	dbSNP
rs1254638003	319	dbSNP
rs1468901052	321	dbSNP
rs192139424	322	dbSNP
rs1055184210	323	dbSNP
rs572696504	343	dbSNP
rs1166489429	345	dbSNP
rs910401425	347	dbSNP
rs928114102	348	dbSNP
rs1213276346	350	dbSNP
rs1335780332	359	dbSNP
rs1046583382	365	dbSNP
rs1286029080	371	dbSNP
rs1009264125	373	dbSNP
rs2278491	374	dbSNP
rs1333739485	388	dbSNP
rs1308507138	391	dbSNP
rs1352313335	392	dbSNP
rs539007473	393	dbSNP
rs1439716545	398	dbSNP
rs957123015	403	dbSNP
rs1230185842	409	dbSNP
rs908825328	409	dbSNP
rs925673011	409	dbSNP
rs1449687193	410	dbSNP
rs1392672502	411	dbSNP
rs1358771232	413	dbSNP
rs984358682	415	dbSNP
rs1325704911	420	dbSNP
rs547034376	423	dbSNP
rs967110835	424	dbSNP
rs1391085539	429	dbSNP
rs1164480684	431	dbSNP
rs1473981050	434	dbSNP
rs920937344	435	dbSNP
rs1185007635	438	dbSNP
rs1468103875	439	dbSNP
rs1362711185	442	dbSNP
rs1179127080	443	dbSNP
rs756708707	445	dbSNP
rs767217444	446	dbSNP
rs1250874452	447	dbSNP
rs1014536556	449	dbSNP
rs965543817	457	dbSNP
rs753322372	459	dbSNP
rs998715047	460	dbSNP
rs1005687881	463	dbSNP
rs1347626	464	dbSNP
rs1229223597	466	dbSNP
rs1261408029	474	dbSNP
rs1047215209	476	dbSNP
rs1021528925	489	dbSNP
rs760057958	492	dbSNP
rs893772362	493	dbSNP
rs570367213	498	dbSNP
rs1303120177	499	dbSNP
rs111325017	500	dbSNP
rs906656243	501	dbSNP
rs16888613	504	dbSNP
rs1474145479	510	dbSNP
rs1167223832	512	dbSNP
rs940169151	519	dbSNP
rs34060344	520	dbSNP
rs1048608886	531	dbSNP
rs1334518481	543	dbSNP
rs139060058	550	dbSNP
rs920939028	552	dbSNP
rs1320534618	557	dbSNP
rs1324719920	563	dbSNP
rs975517045	566	dbSNP
rs1347801987	567	dbSNP
rs943787377	567	dbSNP
rs116520740	568	dbSNP
rs773296191	570	dbSNP
rs867234760	574	dbSNP
rs1208896353	580	dbSNP
rs562252730	584	dbSNP
rs1191237144	591	dbSNP
rs977185230	594	dbSNP
rs967174959	595	dbSNP
rs1021475198	600	dbSNP
rs1446686695	603	dbSNP
rs769986775	614	dbSNP
rs1378126620	626	dbSNP
rs1218969275	632	dbSNP
rs1400164185	633	dbSNP
rs1174196105	635	dbSNP
rs1346324050	637	dbSNP
rs1280170354	638	dbSNP
rs1362259437	653	dbSNP
rs952879230	655	dbSNP
rs958911093	656	dbSNP
rs1235674681	661	dbSNP
rs1347525964	667	dbSNP
rs1383135514	671	dbSNP
rs374187945	672	dbSNP
rs761890073	673	dbSNP
rs1347927415	678	dbSNP
rs1268838628	679	dbSNP
rs1033673881	680	dbSNP
rs1002639618	681	dbSNP
rs1025802074	688	dbSNP
rs1330197320	694	dbSNP
rs906562746	695	dbSNP
rs1024986026	703	dbSNP
rs1373102461	705	dbSNP
rs1204019609	707	dbSNP
rs1004264666	708	dbSNP
rs1267365439	709	dbSNP
rs887240007	710	dbSNP
rs901232696	712	dbSNP
rs1268122638	717	dbSNP
rs1049079782	725	dbSNP
rs931575671	726	dbSNP
rs1362276086	730	dbSNP
rs1164063754	737	dbSNP
rs889777601	740	dbSNP
rs1165976754	743	dbSNP
rs1303026978	744	dbSNP
rs568199783	745	dbSNP
rs1176492922	752	dbSNP
rs1393475367	753	dbSNP
rs547016291	755	dbSNP
rs1237794943	756	dbSNP
rs12545964	756	dbSNP
rs768603283	760	dbSNP
rs1292088808	773	dbSNP
rs1196130722	780	dbSNP
rs943659901	781	dbSNP
rs1290906423	789	dbSNP
rs56089108	800	dbSNP
rs977134716	802	dbSNP
rs546539780	820	dbSNP
rs1041913294	825	dbSNP
rs1418290598	826	dbSNP
rs765702631	828	dbSNP
rs1188460393	832	dbSNP
rs1387344249	838	dbSNP
rs1444675145	841	dbSNP
rs1424077605	846	dbSNP
rs61040507	847	dbSNP
rs1463924767	854	dbSNP
rs1296957695	861	dbSNP
rs914408283	874	dbSNP
rs1214409405	879	dbSNP
rs779865387	880	dbSNP
rs1340520837	888	dbSNP
rs990419029	891	dbSNP
rs1220128133	894	dbSNP
rs1384593283	899	dbSNP
rs958631842	900	dbSNP
rs1243131265	906	dbSNP
rs1313814868	910	dbSNP
rs1307583694	922	dbSNP
rs1034657333	925	dbSNP
rs992581406	926	dbSNP
rs1204118083	928	dbSNP
rs981394901	932	dbSNP
rs970671403	934	dbSNP
rs1311794165	938	dbSNP
rs563276758	949	dbSNP
rs1004253229	953	dbSNP
rs1430410491	954	dbSNP
rs1263687608	958	dbSNP
rs1245562056	959	dbSNP
rs1360888178	961	dbSNP
rs1326588565	966	dbSNP
rs1373056761	970	dbSNP
rs887228147	972	dbSNP
rs143353925	976	dbSNP
rs996099918	980	dbSNP
rs984399120	983	dbSNP
rs900014037	987	dbSNP
rs952908799	988	dbSNP
rs1424075432	998	dbSNP
rs1025838027	1003	dbSNP
rs1223895720	1007	dbSNP
rs1264840813	1012	dbSNP
rs1459815806	1020	dbSNP
rs542449295	1029	dbSNP
rs944279924	1030	dbSNP
rs1203221488	1038	dbSNP
rs1242935979	1041	dbSNP
rs1486875203	1045	dbSNP
rs1184897538	1049	dbSNP
rs200414230	1050	dbSNP
rs1434311763	1054	dbSNP
rs532811618	1055	dbSNP
rs1427557868	1061	dbSNP
rs528419169	1062	dbSNP
rs1175205106	1068	dbSNP
rs965501216	1073	dbSNP
rs1432253619	1075	dbSNP
rs574445090	1077	dbSNP
rs759977578	1078	dbSNP
rs1474361719	1080	dbSNP
rs890755467	1085	dbSNP
rs1020152849	1086	dbSNP
rs1006974658	1090	dbSNP
rs889808598	1106	dbSNP
rs1172776503	1112	dbSNP
rs1041442896	1118	dbSNP
rs75651664	1124	dbSNP
rs1246528333	1128	dbSNP
rs7831811	1129	dbSNP
rs116970156	1135	dbSNP
rs1041559420	1138	dbSNP
rs558404214	1139	dbSNP
rs1490535750	1146	dbSNP
rs937142805	1146	dbSNP
rs1202175127	1153	dbSNP
rs368831129	1157	dbSNP
rs1465701988	1162	dbSNP
rs61477270	1164	dbSNP
rs1260423908	1167	dbSNP
rs532513593	1171	dbSNP
rs1178183991	1183	dbSNP
rs1057305679	1184	dbSNP
rs1402147979	1185	dbSNP
rs1156515372	1191	dbSNP
rs1250436667	1192	dbSNP
rs543483969	1194	dbSNP
rs1424766758	1198	dbSNP
rs1304852556	1208	dbSNP
rs113974512	1214	dbSNP
rs1343604961	1215	dbSNP
rs1202644764	1223	dbSNP
rs971329450	1229	dbSNP
rs917911280	1233	dbSNP
rs759577984	1234	dbSNP
rs926956452	1234	dbSNP
rs1222211670	1240	dbSNP
rs1306600362	1240	dbSNP
rs1380724789	1242	dbSNP
rs1277630469	1243	dbSNP
rs1290183538	1246	dbSNP
rs1441427806	1253	dbSNP
rs982776692	1263	dbSNP
rs375546762	1266	dbSNP
rs1333177345	1268	dbSNP
rs1468950255	1273	dbSNP
rs1175064722	1283	dbSNP
rs931557862	1284	dbSNP
rs1444679140	1287	dbSNP
rs1363621570	1290	dbSNP
rs918802668	1290	dbSNP
rs973002919	1297	dbSNP
rs536495905	1309	dbSNP
rs1356021643	1316	dbSNP
rs1419958049	1318	dbSNP
rs1279167444	1325	dbSNP
rs995615395	1327	dbSNP
rs985978130	1328	dbSNP
rs1313086166	1334	dbSNP
rs568560729	1342	dbSNP
rs1441888044	1351	dbSNP
rs1405927429	1352	dbSNP
rs141040526	1360	dbSNP
rs1440905482	1364	dbSNP
rs1237179242	1368	dbSNP
rs528475183	1372	dbSNP
rs543580272	1377	dbSNP
rs777367762	1382	dbSNP
rs1008480535	1383	dbSNP
rs755571119	1384	dbSNP
rs564447181	1386	dbSNP
rs776752287	1388	dbSNP
rs1020658787	1399	dbSNP
rs1322954943	1409	dbSNP
rs185529574	1410	dbSNP
rs1454732069	1415	dbSNP
rs1239309865	1420	dbSNP
rs147292194	1428	dbSNP
rs55780023	1431	dbSNP
rs1054579342	1436	dbSNP
rs1369984722	1444	dbSNP
rs937112209	1445	dbSNP
rs1338088193	1448	dbSNP
rs927118490	1449	dbSNP
rs1294303166	1452	dbSNP
rs1045576597	1472	dbSNP
rs1459663790	1476	dbSNP
rs949960031	1476	dbSNP
rs1048102529	1479	dbSNP
rs1264080150	1480	dbSNP
rs907819607	1488	dbSNP
rs1240911286	1496	dbSNP
rs1158531700	1498	dbSNP
rs1441314933	1506	dbSNP
rs766827208	1518	dbSNP
rs918258844	1529	dbSNP
rs1172329640	1530	dbSNP
rs1037714074	1538	dbSNP
rs35382101	1548	dbSNP
rs1454054977	1549	dbSNP
rs542055031	1550	dbSNP
rs912736585	1554	dbSNP
rs1191363992	1557	dbSNP
rs1382841382	1565	dbSNP
rs1489286237	1569	dbSNP
rs1239829233	1570	dbSNP
rs1215333730	1578	dbSNP
rs1353818494	1581	dbSNP
rs985569980	1583	dbSNP
rs951427446	1605	dbSNP
rs1232033971	1607	dbSNP
rs1284519104	1608	dbSNP
rs954136736	1616	dbSNP
rs575017157	1620	dbSNP
rs1343939720	1625	dbSNP
rs1205194279	1641	dbSNP
rs1388713770	1642	dbSNP
rs748204444	1648	dbSNP
rs1360214072	1649	dbSNP
rs141947282	1650	dbSNP
rs750735909	1655	dbSNP
rs148103182	1658	dbSNP
rs1377268077	1664	dbSNP
rs143732200	1680	dbSNP
rs955544262	1682	dbSNP
rs769565618	1685	dbSNP
rs1419198065	1686	dbSNP
rs1010581376	1687	dbSNP
rs959958149	1702	dbSNP
rs1403487069	1705	dbSNP
rs1301086844	1707	dbSNP
rs1336742221	1709	dbSNP
rs1239236868	1716	dbSNP
rs372847850	1728	dbSNP
rs1434664981	1733	dbSNP
rs1378551461	1734	dbSNP
rs745684621	1741	dbSNP
rs1295044576	1742	dbSNP
rs558095042	1745	dbSNP
rs1010500570	1749	dbSNP
rs1490835869	1751	dbSNP
rs144994204	1755	dbSNP
rs1192489314	1756	dbSNP
rs1184189615	1761	dbSNP
rs1362328699	1762	dbSNP
rs1439131448	1764	dbSNP
rs1164370764	1768	dbSNP
rs1367995288	1769	dbSNP
rs1423214522	1786	dbSNP
rs780784295	1795	dbSNP
rs1397593900	1796	dbSNP
rs1393528448	1797	dbSNP
rs543412801	1799	dbSNP
rs1264735496	1800	dbSNP
rs905689565	1803	dbSNP
rs892754940	1805	dbSNP
rs117828981	1809	dbSNP
rs1360994950	1814	dbSNP
rs1242456987	1816	dbSNP
rs1001687072	1819	dbSNP
rs554892007	1821	dbSNP
rs1256367002	1823	dbSNP
rs1045525547	1825	dbSNP
rs202081828	1830	dbSNP
rs1235211105	1835	dbSNP
rs1457536668	1835	dbSNP
rs1184444085	1837	dbSNP
rs75402124	1846	dbSNP
rs1277725732	1862	dbSNP
rs73701317	1864	dbSNP
rs1342393955	1872	dbSNP
rs554034168	1877	dbSNP
rs535088513	1887	dbSNP
rs570969219	1895	dbSNP
rs55846724	1909	dbSNP
rs919918641	1920	dbSNP
rs1400038235	1921	dbSNP
rs925435739	1926	dbSNP
rs979513837	1927	dbSNP
rs1393834317	1931	dbSNP
rs1311891192	1932	dbSNP
rs200105485	1945	dbSNP
rs1255843339	1946	dbSNP
rs1317080619	1948	dbSNP
rs575934635	1954	dbSNP
rs911287444	1962	dbSNP
rs570244625	1980	dbSNP
rs986896681	1985	dbSNP
rs1245230402	1987	dbSNP
rs572416399	1988	dbSNP
rs576243086	1991	dbSNP
rs989468268	1992	dbSNP
rs1430748392	1994	dbSNP
rs957681248	1995	dbSNP
rs1423299908	1998	dbSNP
rs1425115939	1998	dbSNP
rs193102087	2004	dbSNP
rs969904659	2008	dbSNP
rs1407909188	2012	dbSNP
rs1464093531	2014	dbSNP
rs1301822295	2021	dbSNP
rs1185254133	2023	dbSNP
rs1423158178	2025	dbSNP
rs555940575	2026	dbSNP
rs1026807532	2027	dbSNP
rs1202109162	2032	dbSNP
rs995269345	2032	dbSNP
rs1479512020	2034	dbSNP
rs1257212949	2035	dbSNP
rs1033079729	2042	dbSNP
rs1310737240	2048	dbSNP
rs1209693026	2056	dbSNP
rs1001234347	2060	dbSNP
rs1015679008	2062	dbSNP
rs745653542	2063	dbSNP
rs1023977963	2070	dbSNP
rs1486904534	2071	dbSNP
rs1192081867	2073	dbSNP
rs1007927697	2082	dbSNP
rs1480955981	2084	dbSNP
rs1320321888	2089	dbSNP
rs1013964918	2090	dbSNP
rs530210065	2095	dbSNP
rs1431026906	2097	dbSNP
rs890783346	2102	dbSNP
rs1244082719	2109	dbSNP
rs1049989557	2110	dbSNP
rs1365925197	2110	dbSNP
rs1405328490	2115	dbSNP
rs567050053	2115	dbSNP
rs751269283	2117	dbSNP
rs1315392382	2119	dbSNP
rs1365244737	2130	dbSNP
rs1218821224	2131	dbSNP
rs1308019664	2132	dbSNP
rs904041378	2145	dbSNP
rs1390191697	2149	dbSNP
rs369696651	2149	dbSNP
rs886231231	2150	dbSNP
rs1285913448	2165	dbSNP
rs1047592724	2166	dbSNP
rs945453679	2175	dbSNP
rs1245286843	2178	dbSNP
rs913951833	2184	dbSNP
rs1332514564	2187	dbSNP
rs930548554	2194	dbSNP
rs1408312639	2195	dbSNP
rs1440971649	2200	dbSNP
rs1156363819	2203	dbSNP
rs899110444	2209	dbSNP
rs1425164802	2216	dbSNP
rs778708622	2219	dbSNP
rs376532100	2231	dbSNP
rs942689295	2233	dbSNP
rs911235199	2238	dbSNP
rs986844083	2248	dbSNP
rs1375876551	2249	dbSNP
rs770725143	2260	dbSNP
rs187760354	2266	dbSNP
rs919777564	2276	dbSNP
rs973894734	2278	dbSNP
rs1237306001	2279	dbSNP
rs182634167	2287	dbSNP
rs1288418020	2288	dbSNP
rs532036767	2290	dbSNP
rs1459247196	2291	dbSNP
rs1015382621	2328	dbSNP
rs1209503685	2336	dbSNP
rs1458771275	2337	dbSNP
rs1176413676	2344	dbSNP
rs1008374756	2350	dbSNP
rs1444754141	2357	dbSNP
rs1164897791	2359	dbSNP
rs989025082	2382	dbSNP
rs191427071	2389	dbSNP
rs1267357765	2393	dbSNP
rs1237484008	2395	dbSNP
rs1027916104	2398	dbSNP
rs755676342	2405	dbSNP
rs1330957465	2406	dbSNP
rs1376901816	2414	dbSNP
rs980772723	2422	dbSNP
rs761169015	2424	dbSNP
rs747588910	2425	dbSNP
rs536033077	2426	dbSNP
rs780434828	2427	dbSNP
rs1023925506	2438	dbSNP
rs772369023	2439	dbSNP
rs1275488749	2440	dbSNP
rs1449381317	2444	dbSNP
rs1369239985	2447	dbSNP
rs1013955043	2449	dbSNP
rs1196325053	2450	dbSNP
rs950504806	2454	dbSNP
rs1026553571	2457	dbSNP
rs1461360873	2457	dbSNP
rs994702142	2463	dbSNP
rs1235659950	2469	dbSNP
rs2118108	2472	dbSNP
rs1187050592	2473	dbSNP
rs1390795498	2480	dbSNP
rs541689130	2484	dbSNP
rs765797308	2484	dbSNP
rs1164534455	2486	dbSNP
rs1417782813	2490	dbSNP
rs1407172289	2491	dbSNP
rs1416227267	2494	dbSNP
rs1332346446	2496	dbSNP
rs1339946152	2503	dbSNP
rs1038917885	2508	dbSNP
rs1379677622	2510	dbSNP
rs1007892518	2512	dbSNP
rs1009774241	2513	dbSNP
rs892627453	2517	dbSNP
rs889789345	2524	dbSNP
rs1051132390	2530	dbSNP
rs576025437	2537	dbSNP
rs10464860	2543	dbSNP
rs114282547	2547	dbSNP
rs1216357635	2549	dbSNP
rs1452451793	2554	dbSNP
rs1053633086	2560	dbSNP
rs571180728	2561	dbSNP
rs1269557526	2566	dbSNP
rs1192740427	2572	dbSNP
rs1203532437	2573	dbSNP
rs1479089251	2574	dbSNP
rs936152761	2575	dbSNP
rs1287280547	2576	dbSNP
rs1401402905	2578	dbSNP
rs926120822	2580	dbSNP
rs1359253003	2583	dbSNP
rs201559233	2583	dbSNP
rs1346106178	2587	dbSNP
rs1274681212	2592	dbSNP
rs1284253974	2594	dbSNP
rs980338575	2595	dbSNP
rs970321270	2598	dbSNP
rs908357635	2610	dbSNP
rs1232037426	2613	dbSNP
rs1168416077	2614	dbSNP
rs1272749588	2624	dbSNP
rs986579391	2627	dbSNP
rs572389234	2640	dbSNP
rs1324938733	2650	dbSNP
rs1288056194	2666	dbSNP
rs757512306	2669	dbSNP
rs1215809550	2683	dbSNP
rs950451423	2684	dbSNP
rs955099760	2687	dbSNP
rs201175635	2690	dbSNP
rs1026039571	2694	dbSNP
rs995004229	2696	dbSNP
rs1027945518	2698	dbSNP
rs1470546849	2711	dbSNP
rs556056597	2711	dbSNP
rs1450479339	2718	dbSNP
rs963205156	2719	dbSNP
rs967678372	2724	dbSNP
rs1378554627	2733	dbSNP
rs766724348	2734	dbSNP
rs200018892	2736	dbSNP
rs1007474765	2751	dbSNP
rs890409340	2755	dbSNP
rs553970916	2763	dbSNP
rs892666265	2765	dbSNP
rs1051078062	2773	dbSNP
rs1191778185	2782	dbSNP
rs538841566	2783	dbSNP
rs570955186	2785	dbSNP
rs1292465731	2786	dbSNP
rs1180601884	2791	dbSNP
rs1053174914	2792	dbSNP
rs559049390	2795	dbSNP
rs1207906499	2796	dbSNP
rs1266938743	2801	dbSNP
rs1438544107	2804	dbSNP
rs536783964	2810	dbSNP
rs186936486	2816	dbSNP
rs1278358565	2824	dbSNP
rs1439196277	2825	dbSNP
rs1220235789	2835	dbSNP
rs1164738594	2836	dbSNP
rs1370751401	2838	dbSNP
rs570060247	2841	dbSNP
rs1276211842	2846	dbSNP
rs548313340	2848	dbSNP
rs930665618	2850	dbSNP
rs562230340	2857	dbSNP
rs566041154	2861	dbSNP
rs760737535	2869	dbSNP
rs948960106	2872	dbSNP
rs547537302	2876	dbSNP

- PLoS pathogens, 2012

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.