miRTarBase - #MIRT495602


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pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol NKX2-5   
Synonyms CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3
Description NK2 homeobox 5
Transcript NM_001166175   
Other Transcripts NM_001166176 , NM_004387   
Expression
Putative miRNA Targets on NKX2-5
3'UTR of NKX2-5
(miRNA target sites are highlighted)		 
>NKX2-5|NM_001166175|3'UTR
   1 AATTTTAAGTCACCGTCTGTCTCCCTCACCAGGGTGTGAACTGCCCCGAGGGCAGAGACCTCCCGTTTTGTTCTCCAGCG
  81 CCTTGAGCCAGCCTGACTTTCTACAAATGCTGAGTGAGACGTGTCGGTGGCTCCCAGTGCACTTGGCAGAGTGAGCCGCA
 161 GCCAGCTGGGCGCTCCAGGCAGGACACAGTGGCCTCCACGAGGATCCCTTACCATTACTGTGCGGCCGCGCTCCGTAGGT
 241 CAAGCCGCTCTTACCAAGCGTCTCTCTGCCTCTCTGTTCCCCCTCAGAGCTGTGCGCGCTGCAGAAGGCGGTGGAGCTGG
 321 AGAAGACAGAGGCGGACAACGCGGAGCGGCCCCGGGCGCGACGGCGGAGGAAGCCGCGCGTGCTCTTCTCGCAGGCGCAG
 401 GTCTATGAGCTGGAGCGGCGCTTCAAGCAGCAGCGGTACCTGTCGGCCCCCGAACGCGACCAGCTGGCCAGCGTGCTGAA
 481 ACTCACGTCCACGCAGGTCAAGATCTGGTTCCAGAACCGGCGCTACAAGTGCAAGCGGCAGCGGCAGGACCAGACTCTGG
 561 AGCTGGTGGGGCTGCCCCCGCCGCCGCCGCCGCCTGCCCGCAGGATCGCGGTGCCAGTGCTGGTGCGCGATGGCAAGCCA
 641 TGCCTAGGGGACTCGGCGCCCTACGCGCCTGCCTACGGCGTGGGCCTCAATCCCTACGGTTATAACGCCTACCCCGCCTA
 721 TCCGGGTTACGGCGGCGCGGCCTGCAGCCCTGGCTACAGCTGCACTGCCGCTTACCCCGCCGGGCCTTCCCCAGCGCAGC
 801 CGGCCACTGCCGCCGCCAACAACAACTTCGTGAACTTCGGCGTCGGGGACTTGAATGCGGTTCAGAGCCCCGGGATTCCG
 881 CAGAGCAACTCGGGAGTGTCCACGCTGCATGGTATCCGAGCCTGGTAGGGAAGGGACCCGCGTGGCGCGACCCTGACCGA
 961 TCCCACCTCAACAGCTCCCTGACTCTCGGGGGGAGAAGGGGCTCCCAACATGACCCTGAGTCCCCTGGATTTTGCATTCA
1041 CTCCTGCGGAGACCTAGGAACTTTTTCTGTCCCACGCGCGTTTGTTCTTGCGCACGGGAGAGTTTGTGGCGGCGATTATG
1121 CAGCGTGCAATGAGTGATCCTGCAGCCTGGTGTCTTAGCTGTCCCCCCAGGAGTGCCCTCCGAGAGTCCATGGGCACCCC
1201 CGGTTGGAACTGGGACTGAGCTCGGGCACGCAGGGCCTGAGATCTGGCCGCCCATTCCGCGAGCCAGGGCCGGGCGCCCG
1281 GGCCTTTGCTATCTCGCCGTCGCCCGCCCACGCACCCACCCGTATTTATGTTTTTACCTATTGCTGTAAGAAATGACGAT
1361 CCCCTTCCCATTAAAGAGAGTGCGTTGACCCCG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgUCGGUCG---AGAUGGGGGCGGu 5'
            |||::|:    ||:|||||||| 
Target 5' ggAGCTGGTGGGGCTGCCCCCGCCg 3'
 559 - 583 164.00 -33.90
2 
miRNA  3' cguCGGUCGAGAUGGGGGCGGu 5'
             ||| ||| || ||||||| 
Target 5' actGCC-GCT-TA-CCCCGCCg 3'
 764 - 782 156.00 -27.00
3 
miRNA  3' cgucgguCGAGAUGGGGGCGGu 5'
                 || ||| ||||||| 
Target 5' ttataacGC-CTA-CCCCGCCt 3'
 700 - 719 149.00 -19.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1012753 30 ClinVar
190833 126 ClinVar
1200887 206 ClinVar
219167 268 ClinVar
219166 276 ClinVar
468243 281 ClinVar
229066 285 ClinVar
219165 287 ClinVar
518562 295 ClinVar
9018 308 ClinVar
372743 309 ClinVar
509901 310 ClinVar
749105 310 ClinVar
583193 329 ClinVar
536135 330 ClinVar
30113 333 ClinVar
1145208 334 ClinVar
1079534 340 ClinVar
939551 340 ClinVar
219168 344 ClinVar
519016 348 ClinVar
809843 351 ClinVar
44835 355 ClinVar
453129 361 ClinVar
765116 361 ClinVar
1054388 374 ClinVar
536137 383 ClinVar
942230 384 ClinVar
1136437 385 ClinVar
44836 390 ClinVar
982415 393 ClinVar
219169 396 ClinVar
235042 397 ClinVar
716748 397 ClinVar
1193241 399 ClinVar
468244 400 ClinVar
518495 401 ClinVar
519146 403 ClinVar
1066083 411 ClinVar
156158 414 ClinVar
1071005 416 ClinVar
159255 426 ClinVar
373685 427 ClinVar
211670 433 ClinVar
9019 435 ClinVar
848998 439 ClinVar
519074 444 ClinVar
517696 445 ClinVar
834767 452 ClinVar
9005 461 ClinVar
211671 465 ClinVar
239930 467 ClinVar
190838 470 ClinVar
1021042 474 ClinVar
961454 477 ClinVar
9004 486 ClinVar
1134964 487 ClinVar
36658 496 ClinVar
36659 496 ClinVar
9020 500 ClinVar
1041189 506 ClinVar
211672 507 ClinVar
190839 508 ClinVar
1156481 514 ClinVar
817305 514 ClinVar
190834 519 ClinVar
577954 519 ClinVar
9016 521 ClinVar
509962 536 ClinVar
190835 543 ClinVar
451393 543 ClinVar
1087605 544 ClinVar
9006 545 ClinVar
259380 547 ClinVar
1072792 553 ClinVar
939374 558 ClinVar
159256 559 ClinVar
536136 560 ClinVar
519328 561 ClinVar
681683 562 ClinVar
156159 572 ClinVar
190836 585 ClinVar
1008406 586 ClinVar
1055168 588 ClinVar
211673 588 ClinVar
862013 588 ClinVar
848424 590 ClinVar
757881 592 ClinVar
1061973 595 ClinVar
410968 595 ClinVar
416513 595 ClinVar
1088905 598 ClinVar
9010 599 ClinVar
1016187 603 ClinVar
536138 608 ClinVar
9011 609 ClinVar
1160720 610 ClinVar
496237 615 ClinVar
661306 622 ClinVar
940953 626 ClinVar
858545 629 ClinVar
195219 640 ClinVar
1203227 648 ClinVar
390482 654 ClinVar
758554 658 ClinVar
410970 659 ClinVar
941044 659 ClinVar
39433 660 ClinVar
859023 662 ClinVar
523473 664 ClinVar
1081034 676 ClinVar
536132 677 ClinVar
846645 677 ClinVar
156160 682 ClinVar
429363 696 ClinVar
1039532 705 ClinVar
242906 706 ClinVar
519318 706 ClinVar
691711 708 ClinVar
254163 721 ClinVar
9017 721 ClinVar
283727 722 ClinVar
30117 722 ClinVar
510927 724 ClinVar
379617 730 ClinVar
159257 737 ClinVar
934054 752 ClinVar
1014728 757 ClinVar
156161 762 ClinVar
1152870 772 ClinVar
580887 776 ClinVar
410967 777 ClinVar
1053617 779 ClinVar
392351 780 ClinVar
871625 790 ClinVar
468246 792 ClinVar
837477 795 ClinVar
30115 801 ClinVar
836056 804 ClinVar
378275 805 ClinVar
138525 814 ClinVar
641629 822 ClinVar
410969 827 ClinVar
468247 835 ClinVar
1047644 838 ClinVar
859947 838 ClinVar
453141 839 ClinVar
519139 840 ClinVar
468248 842 ClinVar
520891 845 ClinVar
1161288 847 ClinVar
9014 849 ClinVar
416512 850 ClinVar
759548 851 ClinVar
519109 859 ClinVar
1040347 860 ClinVar
234754 891 ClinVar
1112242 892 ClinVar
468249 896 ClinVar
665881 906 ClinVar
519292 909 ClinVar
1150486 910 ClinVar
515046 922 ClinVar
211668 989 ClinVar
1201176 1125 ClinVar
COSN30615899 52 COSMIC
COSN25953737 154 COSMIC
COSN30191817 234 COSMIC
COSN30738952 247 COSMIC
COSN24382683 277 COSMIC
COSM7656544 285 COSMIC
COSM246045 295 COSMIC
COSM4635247 299 COSMIC
COSM7915681 304 COSMIC
COSM8794227 309 COSMIC
COSM5356822 321 COSMIC
COSM7120379 329 COSMIC
COSM5497816 337 COSMIC
COSM3853765 340 COSMIC
COSM6726630 341 COSMIC
COSM6423768 347 COSMIC
COSM3853764 358 COSMIC
COSM6584584 367 COSMIC
COSM322038 372 COSMIC
COSM5344905 380 COSMIC
COSM4797986 383 COSMIC
COSM9606375 395 COSMIC
COSM3853763 397 COSMIC
COSM4908255 400 COSMIC
COSM7617184 413 COSMIC
COSM6726633 417 COSMIC
COSM1217397 419 COSMIC
COSM3697147 420 COSMIC
COSM9347513 426 COSMIC
COSM1436060 434 COSMIC
COSM6170629 434 COSMIC
COSM7591277 438 COSMIC
COSM5702766 452 COSMIC
COSM6383410 456 COSMIC
COSM3853762 457 COSMIC
COSM4763584 459 COSMIC
COSM6726634 492 COSMIC
COSM7830357 500 COSMIC
COSM5904560 502 COSMIC
COSM1217398 504 COSMIC
COSM9389310 511 COSMIC
COSM5737427 521 COSMIC
COSM6726631 522 COSMIC
COSM1436059 537 COSMIC
COSM6513649 548 COSMIC
COSM8502949 575 COSMIC
COSM5163529 578 COSMIC
COSM3994192 580 COSMIC
COSM9104173 580 COSMIC
COSM8317232 585 COSMIC
COSM5621385 593 COSMIC
COSM6371180 603 COSMIC
COSM8677068 609 COSMIC
COSM6726636 614 COSMIC
COSM7484422 622 COSMIC
COSM336822 626 COSMIC
COSM4635246 628 COSMIC
COSM1286608 634 COSMIC
COSM4763583 638 COSMIC
COSM7484347 647 COSMIC
COSM9696360 648 COSMIC
COSM9590635 650 COSMIC
COSM7639756 654 COSMIC
COSM1259160 658 COSMIC
COSM6726635 664 COSMIC
COSM4646279 668 COSMIC
COSM6170630 675 COSMIC
COSM8045817 677 COSMIC
COSM8184210 680 COSMIC
COSM4141682 681 COSMIC
COSM5796179 688 COSMIC
COSM7379683 695 COSMIC
COSM1259159 697 COSMIC
COSM4628410 706 COSMIC
COSM737687 706 COSMIC
COSM737688 711 COSMIC
COSM9851328 711 COSMIC
COSM4707088 715 COSMIC
COSM7379684 723 COSMIC
COSM7785705 725 COSMIC
COSM3827699 733 COSMIC
COSM5060946 734 COSMIC
COSM8718930 736 COSMIC
COSM3994191 770 COSMIC
COSM4159738 774 COSMIC
COSM3919699 776 COSMIC
COSM4707087 782 COSMIC
COSM8690199 785 COSMIC
COSM5835009 788 COSMIC
COSM5903550 791 COSMIC
COSM1259161 796 COSMIC
COSM9008493 799 COSMIC
COSM7807759 802 COSMIC
COSM1286609 810 COSMIC
COSM8810014 811 COSMIC
COSM7187716 816 COSMIC
COSM8674048 817 COSMIC
COSM3339840 819 COSMIC
COSM5669368 822 COSMIC
COSM295285 829 COSMIC
COSM6103379 830 COSMIC
COSM1696764 834 COSMIC
COSM1259156 841 COSMIC
COSM1259157 842 COSMIC
COSM8355275 844 COSMIC
COSM6103380 845 COSMIC
COSM8728500 845 COSMIC
COSM7518371 847 COSMIC
COSM1065900 852 COSMIC
COSM1217396 858 COSMIC
COSM367714 859 COSMIC
COSM7984313 872 COSMIC
COSM5905626 873 COSMIC
COSM8235685 879 COSMIC
COSM322039 885 COSMIC
COSM4599287 888 COSMIC
COSM3674395 892 COSMIC
COSM5868175 893 COSMIC
COSM7808299 900 COSMIC
COSM4707086 903 COSMIC
COSM396585 908 COSMIC
COSM3853761 917 COSMIC
COSN24401337 946 COSMIC
COSN31586598 947 COSMIC
COSN31493829 949 COSMIC
COSN30472215 959 COSMIC
COSN29468627 969 COSMIC
COSN26504989 976 COSMIC
COSN18729974 989 COSMIC
COSN15662258 995 COSMIC
COSN9420573 1067 COSMIC
COSN31553724 1075 COSMIC
COSN31485718 1087 COSMIC
COSN20075401 1113 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770265328 1 dbSNP
rs1321313193 2 dbSNP
rs1286958346 3 dbSNP
rs1312906350 3 dbSNP
rs1454114402 11 dbSNP
rs1463227694 13 dbSNP
rs1340477898 14 dbSNP
rs1327614493 15 dbSNP
rs1242613336 28 dbSNP
rs1407803816 32 dbSNP
rs1451685747 33 dbSNP
rs571495972 34 dbSNP
rs1374683310 39 dbSNP
rs770760092 46 dbSNP
rs1308631223 47 dbSNP
rs1387273472 48 dbSNP
rs1478644699 50 dbSNP
rs1424496401 55 dbSNP
rs1383924409 65 dbSNP
rs957107634 69 dbSNP
rs1409877338 75 dbSNP
rs1185898490 79 dbSNP
rs1473422497 84 dbSNP
rs747848277 86 dbSNP
rs551687864 88 dbSNP
rs1179788661 90 dbSNP
rs1439747296 99 dbSNP
rs1275683993 101 dbSNP
rs1013341984 103 dbSNP
rs1383689797 109 dbSNP
rs1321423294 114 dbSNP
rs1205592625 118 dbSNP
rs1369711208 125 dbSNP
rs960618881 125 dbSNP
rs200039950 126 dbSNP
rs1229899239 130 dbSNP
rs1356987991 133 dbSNP
rs1278401728 134 dbSNP
rs1268348426 137 dbSNP
rs1439440205 140 dbSNP
rs756023940 141 dbSNP
rs1308330747 145 dbSNP
rs1403962830 147 dbSNP
rs1364044458 151 dbSNP
rs995830063 158 dbSNP
rs752622656 162 dbSNP
rs1407945612 163 dbSNP
rs1156872524 166 dbSNP
rs1471231639 167 dbSNP
rs531906439 171 dbSNP
rs1267123095 177 dbSNP
rs1198885991 178 dbSNP
rs904138561 180 dbSNP
rs754529078 181 dbSNP
rs754621501 183 dbSNP
rs1005179646 185 dbSNP
rs751313458 187 dbSNP
rs1410445956 188 dbSNP
rs770676433 190 dbSNP
rs1472291030 194 dbSNP
rs766100070 196 dbSNP
rs1452075749 197 dbSNP
rs762628091 200 dbSNP
rs1414462775 203 dbSNP
rs183405705 206 dbSNP
rs549757001 207 dbSNP
rs1389780378 213 dbSNP
rs879431143 219 dbSNP
rs1204358435 220 dbSNP
rs1460973806 223 dbSNP
rs931435740 224 dbSNP
rs898576488 234 dbSNP
rs1221573220 237 dbSNP
rs750776969 238 dbSNP
rs1242186677 240 dbSNP
rs1265186476 241 dbSNP
rs765580232 241 dbSNP
rs1055750325 245 dbSNP
rs375144677 247 dbSNP
rs1417503345 253 dbSNP
rs762234952 259 dbSNP
rs777123005 260 dbSNP
rs1295622517 261 dbSNP
rs864321647 268 dbSNP
rs1437693412 269 dbSNP
rs768785239 270 dbSNP
rs1250228777 276 dbSNP
rs864321646 276 dbSNP
rs1379087066 279 dbSNP
rs937339110 281 dbSNP
rs1316920712 284 dbSNP
rs876657934 285 dbSNP
rs864321645 287 dbSNP
rs1402954982 289 dbSNP
rs760723447 295 dbSNP
rs1483052303 296 dbSNP
rs529610517 297 dbSNP
rs112167223 300 dbSNP
rs137852684 308 dbSNP
rs369025518 309 dbSNP
rs769566306 310 dbSNP
rs1488724798 311 dbSNP
rs913442600 312 dbSNP
rs1241311366 318 dbSNP
rs748099661 319 dbSNP
rs1466216124 320 dbSNP
rs990310551 322 dbSNP
rs781260821 323 dbSNP
rs1320947604 330 dbSNP
rs754582136 331 dbSNP
rs1220171192 332 dbSNP
rs387906774 333 dbSNP
rs957139658 334 dbSNP
rs779663474 335 dbSNP
rs1390061166 337 dbSNP
rs758000160 338 dbSNP
rs750029908 340 dbSNP
rs1408552697 343 dbSNP
rs864321648 344 dbSNP
rs765590955 345 dbSNP
rs757630702 347 dbSNP
rs754394393 348 dbSNP
rs1184594159 350 dbSNP
rs1451226218 352 dbSNP
rs1248623506 353 dbSNP
rs1182433334 354 dbSNP
rs397516908 356 dbSNP
rs764551904 357 dbSNP
rs1257246534 359 dbSNP
rs866619868 360 dbSNP
rs974468549 361 dbSNP
rs1260214548 362 dbSNP
rs761127819 363 dbSNP
rs775565717 364 dbSNP
rs1366528649 366 dbSNP
rs767571259 367 dbSNP
rs759682128 369 dbSNP
rs1451105190 370 dbSNP
rs1253114866 372 dbSNP
rs774627537 374 dbSNP
rs1303521925 375 dbSNP
rs769534216 376 dbSNP
rs1353021443 380 dbSNP
rs1166464754 382 dbSNP
rs1431464297 383 dbSNP
rs747932354 384 dbSNP
rs1182838417 385 dbSNP
rs72554027 387 dbSNP
rs758277832 388 dbSNP
rs1425850321 389 dbSNP
rs397516909 390 dbSNP
rs1442713675 393 dbSNP
rs200665879 394 dbSNP
rs864321649 396 dbSNP
rs776529245 397 dbSNP
rs876661381 397 dbSNP
rs1230869762 400 dbSNP
rs201582515 401 dbSNP
rs376636481 403 dbSNP
rs746885826 405 dbSNP
rs1291524589 407 dbSNP
rs1244358587 409 dbSNP
rs1356254262 410 dbSNP
rs1324062610 413 dbSNP
rs587782928 414 dbSNP
rs909098202 415 dbSNP
rs1390948213 416 dbSNP
rs1018993104 417 dbSNP
rs1310163851 419 dbSNP
rs587784066 426 dbSNP
rs1057518548 427 dbSNP
rs779716505 428 dbSNP
rs1410674749 429 dbSNP
rs1299817619 430 dbSNP
rs757925015 433 dbSNP
rs797045790 434 dbSNP
rs137852685 435 dbSNP
rs1456289029 439 dbSNP
rs778608632 440 dbSNP
rs757605578 441 dbSNP
rs754229011 445 dbSNP
rs984722259 447 dbSNP
rs1409304719 448 dbSNP
rs1183825086 450 dbSNP
rs759503484 451 dbSNP
rs764390691 458 dbSNP
rs756623702 459 dbSNP
rs104893901 461 dbSNP
rs1489743522 463 dbSNP
rs1266609813 464 dbSNP
rs797045791 465 dbSNP
rs878854704 467 dbSNP
rs1298345224 470 dbSNP
rs786205825 470 dbSNP
rs1238421153 473 dbSNP
rs104893900 486 dbSNP
rs1315138203 487 dbSNP
rs3729938 489 dbSNP
rs1290304822 490 dbSNP
rs1256674245 492 dbSNP
rs1229188222 493 dbSNP
rs1345146178 494 dbSNP
rs72554028 496 dbSNP
rs1384912539 497 dbSNP
rs1027477986 499 dbSNP
rs137852686 500 dbSNP
rs1392777285 505 dbSNP
rs797045792 507 dbSNP
rs786205826 508 dbSNP
rs994615466 511 dbSNP
rs767559311 514 dbSNP
rs759647212 518 dbSNP
rs786205824 519 dbSNP
rs1472697249 520 dbSNP
rs104893906 521 dbSNP
rs1431371715 529 dbSNP
rs1428226457 530 dbSNP
rs1197189103 531 dbSNP
rs1435351800 535 dbSNP
rs960527591 536 dbSNP
rs1205001964 538 dbSNP
rs371694530 539 dbSNP
rs1485189311 542 dbSNP
rs774482632 543 dbSNP
rs104893903 545 dbSNP
rs7728764 547 dbSNP
rs1209480214 550 dbSNP
rs763219076 551 dbSNP
rs980492525 556 dbSNP
rs776582660 557 dbSNP
rs768499098 558 dbSNP
rs3729753 559 dbSNP
rs771533553 561 dbSNP
rs376792087 562 dbSNP
rs1386410484 564 dbSNP
rs946354549 565 dbSNP
rs1366026905 566 dbSNP
rs1321948238 568 dbSNP
rs1302021340 570 dbSNP
rs1457368487 570 dbSNP
rs778242550 571 dbSNP
rs587782929 572 dbSNP
rs1170378112 574 dbSNP
rs1226704953 575 dbSNP
rs1467274991 575 dbSNP
rs1378520602 576 dbSNP
rs1267723705 579 dbSNP
rs3729754 585 dbSNP
rs372282873 588 dbSNP
rs1250491634 590 dbSNP
rs753261087 591 dbSNP
rs1190579821 592 dbSNP
rs781707428 594 dbSNP
rs746833511 595 dbSNP
rs777382725 595 dbSNP
rs777981117 595 dbSNP
rs1161668727 597 dbSNP
rs755052461 598 dbSNP
rs104893905 599 dbSNP
rs1201267220 600 dbSNP
rs751684900 603 dbSNP
rs766314872 604 dbSNP
rs888454270 606 dbSNP
rs1226487632 607 dbSNP
rs760305842 608 dbSNP
rs104893902 609 dbSNP
rs990341478 610 dbSNP
rs764041694 616 dbSNP
rs1435738199 620 dbSNP
rs866974584 626 dbSNP
rs760528062 629 dbSNP
rs929243588 630 dbSNP
rs775331755 633 dbSNP
rs1402517013 634 dbSNP
rs772081524 635 dbSNP
rs922066386 636 dbSNP
rs797044675 640 dbSNP
rs1428281500 644 dbSNP
rs1225707941 647 dbSNP
rs759339072 648 dbSNP
rs1222755872 650 dbSNP
rs773922431 654 dbSNP
rs144543503 655 dbSNP
rs749004208 657 dbSNP
rs202071628 658 dbSNP
rs770192204 659 dbSNP
rs397515399 660 dbSNP
rs1470284025 666 dbSNP
rs1204175293 676 dbSNP
rs867226708 677 dbSNP
rs866024579 678 dbSNP
rs781370140 680 dbSNP
rs587782930 682 dbSNP
rs755524589 682 dbSNP
rs966145309 690 dbSNP
rs780348618 692 dbSNP
rs1131691343 696 dbSNP
rs758539727 697 dbSNP
rs919084655 698 dbSNP
rs750726737 699 dbSNP
rs1289763464 702 dbSNP
rs1327849028 705 dbSNP
rs765528024 706 dbSNP
rs879253754 706 dbSNP
rs762090105 708 dbSNP
rs752557173 711 dbSNP
rs767156737 715 dbSNP
rs759518211 716 dbSNP
rs1165063212 719 dbSNP
rs104893907 721 dbSNP
rs387906776 722 dbSNP
rs770484529 723 dbSNP
rs762428190 724 dbSNP
rs772889193 725 dbSNP
rs553883993 729 dbSNP
rs1057520670 730 dbSNP
rs1253659256 733 dbSNP
rs587784067 737 dbSNP
rs747698510 737 dbSNP
rs1450940026 738 dbSNP
rs777059602 743 dbSNP
rs1229530745 744 dbSNP
rs768898597 751 dbSNP
rs780688010 752 dbSNP
rs1226135780 754 dbSNP
rs758595778 758 dbSNP
rs1289353345 759 dbSNP
rs587782931 762 dbSNP
rs994687523 764 dbSNP
rs779089768 770 dbSNP
rs757511605 771 dbSNP
rs753938777 774 dbSNP
rs368366482 776 dbSNP
rs1060503097 777 dbSNP
rs754712373 778 dbSNP
rs1425022333 779 dbSNP
rs751564052 780 dbSNP
rs762836048 781 dbSNP
rs772729751 782 dbSNP
rs1477611443 784 dbSNP
rs571382279 788 dbSNP
rs1223599871 789 dbSNP
rs761596254 792 dbSNP
rs1266892994 794 dbSNP
rs1206339157 795 dbSNP
rs375086983 801 dbSNP
rs769114793 802 dbSNP
rs747608855 803 dbSNP
rs988348581 803 dbSNP
rs374150672 805 dbSNP
rs1188424210 806 dbSNP
rs775959611 811 dbSNP
rs77612903 814 dbSNP
rs746315645 815 dbSNP
rs1054725335 817 dbSNP
rs779136385 820 dbSNP
rs936204422 822 dbSNP
rs1318592912 825 dbSNP
rs756974215 827 dbSNP
rs757275107 827 dbSNP
rs538010963 829 dbSNP
rs749577978 830 dbSNP
rs150581386 838 dbSNP
rs1358735679 839 dbSNP
rs373421818 840 dbSNP
rs569535312 842 dbSNP
rs750356140 844 dbSNP
rs778545351 845 dbSNP
rs549406766 846 dbSNP
rs137852683 849 dbSNP
rs1060504828 850 dbSNP
rs761208569 851 dbSNP
rs763688050 856 dbSNP
rs371380388 858 dbSNP
rs529731562 859 dbSNP
rs772495396 860 dbSNP
rs1310111410 863 dbSNP
rs760182745 868 dbSNP
rs774983960 870 dbSNP
rs771088497 876 dbSNP
rs1296129426 880 dbSNP
rs142368156 885 dbSNP
rs777867699 890 dbSNP
rs769930017 891 dbSNP
rs748311298 892 dbSNP
rs200152391 894 dbSNP
rs1441431049 895 dbSNP
rs201249977 896 dbSNP
rs1414894204 900 dbSNP
rs757182278 904 dbSNP
rs1196710127 909 dbSNP
rs1244640427 910 dbSNP
rs944504713 914 dbSNP
rs376426882 918 dbSNP
rs1188394387 921 dbSNP
rs370499146 922 dbSNP
rs760405249 934 dbSNP
rs752388966 938 dbSNP
rs372969084 940 dbSNP
rs759953857 942 dbSNP
rs775037256 945 dbSNP
rs771371710 948 dbSNP
rs950403805 953 dbSNP
rs773177452 955 dbSNP
rs1386795456 956 dbSNP
rs1231193084 959 dbSNP
rs769914808 967 dbSNP
rs1284583210 976 dbSNP
rs748427974 977 dbSNP
rs1479269551 981 dbSNP
rs1056798903 983 dbSNP
rs973300205 983 dbSNP
rs752958623 988 dbSNP
rs703752 989 dbSNP
rs1343638027 990 dbSNP
rs749630592 992 dbSNP
rs1044783733 993 dbSNP
rs1003777077 995 dbSNP
rs971531341 1004 dbSNP
rs1266320305 1014 dbSNP
rs1449191990 1015 dbSNP
rs1197413788 1022 dbSNP
rs1246685708 1025 dbSNP
rs914890122 1032 dbSNP
rs564938028 1036 dbSNP
rs1409941597 1048 dbSNP
rs1456927023 1049 dbSNP
rs545228657 1054 dbSNP
rs956584932 1069 dbSNP
rs1010292663 1072 dbSNP
rs891811678 1075 dbSNP
rs1344870685 1077 dbSNP
rs1405025051 1087 dbSNP
rs1284651098 1095 dbSNP
rs1271620027 1096 dbSNP
rs1227429108 1102 dbSNP
rs1054418992 1105 dbSNP
rs1353251998 1106 dbSNP
rs1208487114 1110 dbSNP
rs1289782461 1111 dbSNP
rs922852606 1112 dbSNP
rs977410059 1113 dbSNP
rs1325563759 1117 dbSNP
rs1283913213 1120 dbSNP
rs1249743842 1123 dbSNP
rs1222670692 1124 dbSNP
rs191625345 1125 dbSNP
rs562842387 1127 dbSNP
rs1455141412 1136 dbSNP
rs1161314341 1147 dbSNP
rs542542614 1150 dbSNP
rs1005638568 1151 dbSNP
rs900746550 1156 dbSNP
rs375010127 1157 dbSNP
rs574009413 1168 dbSNP
rs1307243026 1170 dbSNP
rs1443145677 1170 dbSNP
rs952798906 1171 dbSNP
rs553775519 1181 dbSNP
rs1314807966 1187 dbSNP
rs767653472 1200 dbSNP
rs1354201241 1201 dbSNP
rs1360732964 1203 dbSNP
rs759744674 1204 dbSNP
rs1025638346 1210 dbSNP
rs1273153918 1212 dbSNP
rs994154686 1214 dbSNP
rs1196518091 1221 dbSNP
rs912038902 1223 dbSNP
rs540202205 1224 dbSNP
rs1056344418 1225 dbSNP
rs1176417405 1226 dbSNP
rs1003904687 1230 dbSNP
rs1445130943 1233 dbSNP
rs1165362933 1243 dbSNP
rs767643001 1243 dbSNP
rs1368688056 1245 dbSNP
rs1461038197 1246 dbSNP
rs1298252178 1251 dbSNP
rs1047945251 1252 dbSNP
rs1414571334 1255 dbSNP
rs1398110608 1258 dbSNP
rs1178159405 1261 dbSNP
rs11552707 1263 dbSNP
rs1393949563 1266 dbSNP
rs929022941 1268 dbSNP
rs1231992842 1272 dbSNP
rs577727386 1275 dbSNP
rs557781840 1276 dbSNP
rs1248687483 1277 dbSNP
rs774298122 1281 dbSNP
rs1307492519 1291 dbSNP
rs1228160143 1294 dbSNP
rs973036130 1298 dbSNP
rs867610321 1312 dbSNP
rs1052152707 1319 dbSNP
rs538476635 1322 dbSNP
rs1349053527 1329 dbSNP
rs770318712 1337 dbSNP
rs1286044133 1340 dbSNP
rs1388169339 1343 dbSNP
rs1427858627 1346 dbSNP
rs982029518 1348 dbSNP
rs970981168 1362 dbSNP
rs1224173303 1366 dbSNP
rs1372841207 1367 dbSNP
rs922267238 1367 dbSNP
rs977025804 1369 dbSNP
rs1464139857 1372 dbSNP
rs1278057042 1380 dbSNP
rs569340672 1383 dbSNP
rs964688288 1384 dbSNP
rs911376098 1385 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1 , LCL-BACD3
Disease MIMAT0027474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected "PAR-CLIP data was present in GSM1020025. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgucgguCGAGAUGGGGGCGGu 5'
                 ||| || ||||||| 
Target 5' -------GCU-UA-CCCCGCCg 3'
 		1 - 13
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000424406.2 | 3UTR | gcuuaccccgccgggc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1020025
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD3 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000424406.2 | 3UTR | gcuuaccccgccgggc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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