miRTarBase - #MIRT495651


—
pre-miRNA Information
pre-miRNA hsa-mir-3921   
Genomic Coordinates chr3: 99964314 - 99964398
Description Homo sapiens miR-3921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3921
Sequence 52| UCUCUGAGUACCAUAUGCCUUGU |74
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN7769671 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs758695096 5 dbSNP
rs539077798 6 dbSNP
rs954620527 10 dbSNP
rs1437951547 17 dbSNP
Putative Targets

Gene Information
Gene Symbol SLC35B2   
Synonyms PAPST1, SLL, UGTrel4
Description solute carrier family 35 member B2
Transcript NM_178148   
Expression
Putative miRNA Targets on SLC35B2
3'UTR of SLC35B2
(miRNA target sites are highlighted)		 
>SLC35B2|NM_178148|3'UTR
   1 GGGTGGAAAGGGCCTGAGGGGTGAAGTGAAATAGGACCCTCCCACCATCCCCTTCTGCTGTAACCTCTGAGGGAGCTGGC
  81 TGAAAGGGCAAAATGCAGGTGTTTTCTCAGTATCACAGACCAGCTCTGCAGCAGGGGATTGGGGAGCCCAGGAGGCAGCC
 161 TTCCCTTTTGCCTTAAGTCACCCATCTTCCAGTAAGCAGTTTATTCTGAGCCCCGGGGGTAGACAGTCCTCAGTGAGGGG
 241 TTTTGGGGAGTTTGGGGTCAAGAGAGCATAGGTAGGTTCCAGTTACTCTTCCCACAAGTTCCCTTAAGTCTTGCCCTAGC
 321 TGTGCTCTGCCACCTTCCAGACTCACTCCCCTCTGCAAATACCTGCATTTCTTACCCTGGTGAGAAAAGCACAAGCGGTG
 401 TAGGCTCCAATGCTGCTTTCCCAGGAGGGTGAAGATGGTGCTGTGCTGAGGAAAGGGGATGCAGAGCCCTGCCCAGCACC
 481 ACCACCTCCTATGCTCCTGGATCCCTAGGCTCTGTTCCATGAGCCTGTTGCAGGTTTTGGTACTTTAGAAATGTAACTTT
 561 TTGCTCTTATAATTTTATTTTATTAAATTAAATTACTGCAGTGGAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUUCCGUAUACCAUGAGUCUCu 5'
            ::||:| |  || ||||| | 
Target 5' cgGGGGTAGACAGTCCTCAGTGa 3'
 214 - 236 129.00 -14.00
2 
miRNA  3' ugUUCCGUAUAC-CAUGAGUCucu 5'
            || ||| :||  | |||||   
Target 5' aaAATGCAGGTGTTTTCTCAGtat 3'
 90 - 113 121.00 -9.32
3 
miRNA  3' uguuccGUAUAC--CAU--GAGUCUCu 5'
                | | ||  |||  ||| ||| 
Target 5' catcccCTTCTGCTGTAACCTCTGAGg 3'
 46 - 72 117.00 -7.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30685942 3 COSMIC
COSN31498240 6 COSMIC
COSN30152339 21 COSMIC
COSN23016809 44 COSMIC
COSN24398054 98 COSMIC
COSN30151086 108 COSMIC
COSN30494800 114 COSMIC
COSN8514389 236 COSMIC
COSN228984 279 COSMIC
COSN31662983 298 COSMIC
COSN19732836 395 COSMIC
COSN19658818 396 COSMIC
COSN9783957 485 COSMIC
COSN26617231 557 COSMIC
COSN16956102 569 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780334263 1 dbSNP
rs375605580 2 dbSNP
rs375633304 6 dbSNP
rs781554904 12 dbSNP
rs1423014112 15 dbSNP
rs1430187254 16 dbSNP
rs372392256 19 dbSNP
rs540231426 20 dbSNP
rs1200265336 21 dbSNP
rs1490197320 22 dbSNP
rs761058485 22 dbSNP
rs369384422 23 dbSNP
rs1219414685 25 dbSNP
rs749582019 26 dbSNP
rs376833492 29 dbSNP
rs1225153237 31 dbSNP
rs773497831 31 dbSNP
rs1314796818 32 dbSNP
rs765896885 33 dbSNP
rs1405081117 34 dbSNP
rs1344308836 36 dbSNP
rs760331162 37 dbSNP
rs1365462262 38 dbSNP
rs371886171 43 dbSNP
rs767282657 47 dbSNP
rs1444914330 50 dbSNP
rs761497003 51 dbSNP
rs1191916689 53 dbSNP
rs1242131539 53 dbSNP
rs1383816741 55 dbSNP
rs1163530012 56 dbSNP
rs561304428 59 dbSNP
rs1014320382 61 dbSNP
rs542627400 62 dbSNP
rs1382924824 66 dbSNP
rs1396057482 69 dbSNP
rs959774266 76 dbSNP
rs899198255 78 dbSNP
rs1037654838 80 dbSNP
rs756150866 81 dbSNP
rs1400283729 82 dbSNP
rs1319075451 84 dbSNP
rs1182425656 86 dbSNP
rs1446493596 87 dbSNP
rs1315024308 90 dbSNP
rs1384140579 91 dbSNP
rs1248705287 94 dbSNP
rs1307510677 95 dbSNP
rs1348113875 97 dbSNP
rs750559022 98 dbSNP
rs1243707017 103 dbSNP
rs1044664597 105 dbSNP
rs1448172174 108 dbSNP
rs1201199130 110 dbSNP
rs1242532910 112 dbSNP
rs1445155092 115 dbSNP
rs1190796064 118 dbSNP
rs533016571 118 dbSNP
rs949920601 120 dbSNP
rs1159317008 121 dbSNP
rs530676359 123 dbSNP
rs1412874877 130 dbSNP
rs1336155652 139 dbSNP
rs372623286 141 dbSNP
rs529772594 141 dbSNP
rs1454990962 144 dbSNP
rs768699767 147 dbSNP
rs777802677 149 dbSNP
rs1225092403 151 dbSNP
rs1237906181 152 dbSNP
rs1279821440 156 dbSNP
rs1352388664 164 dbSNP
rs1221216878 165 dbSNP
rs1011040801 169 dbSNP
rs1461716767 171 dbSNP
rs1357540224 176 dbSNP
rs370363398 181 dbSNP
rs1205443331 183 dbSNP
rs1248179268 192 dbSNP
rs925638052 194 dbSNP
rs978436058 197 dbSNP
rs563243301 198 dbSNP
rs34759278 203 dbSNP
rs964349992 214 dbSNP
rs1342127759 215 dbSNP
rs1479569977 216 dbSNP
rs544947319 219 dbSNP
rs1052493446 220 dbSNP
rs1429994368 220 dbSNP
rs1169101938 221 dbSNP
rs1396378801 224 dbSNP
rs1392403600 227 dbSNP
rs933982132 232 dbSNP
rs577753606 233 dbSNP
rs552921264 235 dbSNP
rs541092934 240 dbSNP
rs1040117936 247 dbSNP
rs1175921194 249 dbSNP
rs573670841 252 dbSNP
rs954940507 256 dbSNP
rs1363263471 260 dbSNP
rs1162376731 262 dbSNP
rs1196213330 262 dbSNP
rs942592978 262 dbSNP
rs1026882942 264 dbSNP
rs1429779460 265 dbSNP
rs993573576 269 dbSNP
rs1269720824 270 dbSNP
rs373505679 271 dbSNP
rs1475043400 272 dbSNP
rs899270498 275 dbSNP
rs1201243104 276 dbSNP
rs111429871 279 dbSNP
rs3832441 280 dbSNP
rs758429705 281 dbSNP
rs111408583 282 dbSNP
rs35131506 282 dbSNP
rs1268401036 286 dbSNP
rs34568497 287 dbSNP
rs35336476 289 dbSNP
rs1037728290 294 dbSNP
rs1205986960 301 dbSNP
rs1302204042 302 dbSNP
rs1002161394 303 dbSNP
rs1345721090 311 dbSNP
rs905156296 316 dbSNP
rs1292799569 317 dbSNP
rs1325797513 319 dbSNP
rs1227979042 320 dbSNP
rs1439683116 322 dbSNP
rs564453758 324 dbSNP
rs144055943 329 dbSNP
rs1270929993 330 dbSNP
rs746846247 332 dbSNP
rs35788918 333 dbSNP
rs3188 334 dbSNP
rs1001629813 342 dbSNP
rs1178044926 342 dbSNP
rs36019662 345 dbSNP
rs113861893 352 dbSNP
rs1184870598 352 dbSNP
rs752505476 362 dbSNP
rs760581033 362 dbSNP
rs1195896733 376 dbSNP
rs1451301739 377 dbSNP
rs1379626775 383 dbSNP
rs1177388401 384 dbSNP
rs557679408 385 dbSNP
rs1480182867 389 dbSNP
rs1417944680 391 dbSNP
rs1269004930 394 dbSNP
rs1459065202 394 dbSNP
rs140212195 395 dbSNP
rs1382731100 396 dbSNP
rs3187 396 dbSNP
rs1011012953 397 dbSNP
rs978475100 398 dbSNP
rs1315408438 399 dbSNP
rs892675799 400 dbSNP
rs1052465276 404 dbSNP
rs943084810 406 dbSNP
rs1347552912 409 dbSNP
rs910207493 410 dbSNP
rs1241908300 411 dbSNP
rs546897964 414 dbSNP
rs1322316234 417 dbSNP
rs1387392274 418 dbSNP
rs1280828471 420 dbSNP
rs901257149 427 dbSNP
rs370093607 428 dbSNP
rs36091687 429 dbSNP
rs1362838400 433 dbSNP
rs1453903670 434 dbSNP
rs1259416681 438 dbSNP
rs942724183 441 dbSNP
rs753475139 448 dbSNP
rs765954926 462 dbSNP
rs929785616 464 dbSNP
rs1346172517 466 dbSNP
rs528551259 467 dbSNP
rs1317743029 468 dbSNP
rs993070174 470 dbSNP
rs1461265280 473 dbSNP
rs1204819441 477 dbSNP
rs1245375769 478 dbSNP
rs1479890133 479 dbSNP
rs1403238914 480 dbSNP
rs1064730 481 dbSNP
rs1176952758 483 dbSNP
rs1345107931 484 dbSNP
rs927049870 485 dbSNP
rs760138857 487 dbSNP
rs767072366 491 dbSNP
rs150712435 496 dbSNP
rs1469486239 503 dbSNP
rs773981740 505 dbSNP
rs1360797412 506 dbSNP
rs1016308699 512 dbSNP
rs1427388229 513 dbSNP
rs772545842 514 dbSNP
rs548917770 517 dbSNP
rs1475765244 518 dbSNP
rs1373059749 521 dbSNP
rs1456669031 523 dbSNP
rs530809450 524 dbSNP
rs1025375632 528 dbSNP
rs1281486427 530 dbSNP
rs1437176605 533 dbSNP
rs1014200953 538 dbSNP
rs1244137918 539 dbSNP
rs1203375785 540 dbSNP
rs1479203067 541 dbSNP
rs1460616510 546 dbSNP
rs1193457723 547 dbSNP
rs895733950 547 dbSNP
rs1197075393 548 dbSNP
rs1204336563 550 dbSNP
rs1480773178 553 dbSNP
rs769593863 558 dbSNP
rs1266301611 559 dbSNP
rs1406765027 562 dbSNP
rs1199508849 563 dbSNP
rs1338678494 567 dbSNP
rs1408091043 571 dbSNP
rs1427260784 571 dbSNP
rs1022502049 572 dbSNP
rs1468136342 572 dbSNP
rs1405165669 578 dbSNP
rs1053000188 579 dbSNP
rs1159546140 581 dbSNP
rs1431883542 581 dbSNP
rs542122737 585 dbSNP
rs1405974738 587 dbSNP
rs762348685 591 dbSNP
rs1405694906 596 dbSNP
rs989726678 596 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1 , LCL-BACD3
Disease MIMAT0018196
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected "PAR-CLIP data was present in GSM1020025. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguucCGUAUACCAUGAGUCUCu 5'
               |: || |   | |:|:| 
Target 5' -----GUCUACG---CGCGGGGc 3'
 		1 - 15
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000393810.1 | 3UTR | gucuacgcgcggggcc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1020025
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD3 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000393810.1 | 3UTR | gucuacgcgcggggcc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
77 hsa-miR-3921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118184 ZNF544 zinc finger protein 544 2 2
MIRT332934 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442165 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442388 CLVS2 clavesin 2 2 2
MIRT442594 SIX1 SIX homeobox 1 2 2
MIRT448015 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448062 MMP15 matrix metallopeptidase 15 2 2
MIRT489018 C1QTNF6 C1q and TNF related 6 2 2
MIRT494457 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495651 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504018 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506778 KLHL15 kelch like family member 15 2 4
MIRT507230 FOXN2 forkhead box N2 2 4
MIRT512551 MFN2 mitofusin 2 2 6
MIRT512843 A1CF APOBEC1 complementation factor 2 6
MIRT513943 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516104 GADL1 glutamate decarboxylase like 1 2 4
MIRT519832 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523209 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525007 ACTN4 actinin alpha 4 2 6
MIRT528859 PKP1 plakophilin 1 2 2
MIRT529061 ZNF675 zinc finger protein 675 2 2
MIRT531720 TARS threonyl-tRNA synthetase 2 2
MIRT534038 STK4 serine/threonine kinase 4 2 2
MIRT543849 APIP APAF1 interacting protein 2 2
MIRT545865 ZNF264 zinc finger protein 264 2 4
MIRT556038 MXD1 MAX dimerization protein 1 2 2
MIRT561346 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562706 ZNF415 zinc finger protein 415 2 2
MIRT563224 ZNF286A zinc finger protein 286A 2 2
MIRT563861 ZNF616 zinc finger protein 616 2 4
MIRT563880 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564653 ZNF487P zinc finger protein 487 1 1
MIRT566596 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570879 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573069 TRIB1 tribbles pseudokinase 1 2 2
MIRT573940 ZNF708 zinc finger protein 708 2 2
MIRT575967 Slfn5 schlafen 5 2 5
MIRT607294 CD300E CD300e molecule 2 4
MIRT608188 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609538 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610153 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611572 SLFN5 schlafen family member 5 2 7
MIRT613336 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616561 ZNF512B zinc finger protein 512B 2 2
MIRT617239 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618012 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618479 IL17REL interleukin 17 receptor E like 2 2
MIRT619100 IFI44L interferon induced protein 44 like 2 2
MIRT622266 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623081 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625622 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627845 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630460 GMPS guanine monophosphate synthase 2 2
MIRT630525 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631503 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634538 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638808 DCTN3 dynactin subunit 3 2 2
MIRT641304 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648348 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649706 ZNF175 zinc finger protein 175 2 2
MIRT652555 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655563 P2RX7 purinergic receptor P2X 7 2 2
MIRT659066 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660342 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664331 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688935 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689972 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699515 SKIL SKI like proto-oncogene 2 2
MIRT699976 RREB1 ras responsive element binding protein 1 2 2
MIRT702675 IRS2 insulin receptor substrate 2 2 2
MIRT709358 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709838 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718717 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718880 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724106 TMEM199 transmembrane protein 199 2 2
MIRT724764 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3921 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC7901)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3921 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-3921 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-3921 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3921 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)

Error report submission