miRTarBase - #MIRT496210


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pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PLEKHG2   
Synonyms ARHGEF42, CLG, CTB-60E11.4, LDAMD
Description pleckstrin homology and RhoGEF domain containing G2
Transcript NM_022835   
Expression
Putative miRNA Targets on PLEKHG2
3'UTR of PLEKHG2
(miRNA target sites are highlighted)		 
>PLEKHG2|NM_022835|3'UTR
   1 GCCAGGACATGAGGCTTCCCTGAAGCAAGGATTTCAGCCAGATGCCATAGACCCTCAGAACTTGACCTGGAAGTCCAGAC
  81 ACTGAACGCAGGCCTCAAAACTGCTGCGGCCTTCCAACTCCTGGTATCTGCATCGGCGAATGGCCCTTCTTGCCTTGATC
 161 CACAGGGATGGGGAAGGGAGGAATGTCATTAATGTTTTGTTAATACTGATTCTTTCATGCAATGATGTGTATTTTCCCAT
 241 TCTGGAGGCTGTGGGAGATGACAAGACAATGAATGGGAAGGTCTGACACAGAACAAATCAGCGGTTCTGAAAGCTTGGGG
 321 AATCTCAGACTCCTTTGAGAATTATTGGAAAATGGACCCACTATAACTTGGCGTGTGTGTGAACTGCTTGATGCCCATCC
 401 AGGAAAGCCAAGTTAAGAAGCTTTGCTTCAAGTAGACACTAGAAATCCATTCCCTTGGCAATTTATACAGTTCACGTCTC
 481 CCACCATCCGTTCATCTCACCCACCCTGCCATCTCTCCACCTATCCATCTGGCTATTGCTCCATCTAGCTTTCCCGCTCC
 561 ATCTACCCATCTTCCAATCCATCATCTCACGTATCTGCCTTGCTTATCCAACTGTCTGCCTTATTCACCCACCCATCCCT
 641 TTATCATTCTAACCCCATCTGGCATTCCATCCCTCCATTTATCCATCTTCCCACTTACCCATCTTCTCCATCCAGCACTC
 721 CGTTCATCAGTCCGTCTCTCCCTCCATATTTCCATCTGTCCATTCATCCACTCATTTTGCCATCCATACATATTCACCCA
 801 GCCATCTCCCAATCCATCGACATACCCCATCCCTCCCTCACTGGACTCTCCGGGGTCTTAGTACTATGATACTTCAGAGA
 881 CAATTCCATGCTGATACGGGGGAGATCAATTTTGGGGCTCTGGGATAAGTCTGTCCCACATCTGTCTGATTTCCCTTGGC
 961 ATCCTTCCCGTCAGTTCCTCTTGAATATCCCAGTTCTTGTACCCACTCACATACCTCAGATCCCTTCACTCCTCCCCGCA
1041 GTTTGCAGCCTCTACAATTCATCCACATGCTCCCTCCCCCAGCAAAATAATTCAGGTCGTGGAGACAAAAGGCTTTTATG
1121 TTAGGTTCTGTCTGCCCCCTTGTTCCAGCAGTGGTATGCCCAGTGAGAGGCACAATTTAAACGGTTTCTTTGGTGATGAT
1201 ATTAGCTACTTTCATCAAATACTTAGCCTCTTGTGCTTTAGCACATTATTTATGTAAGCTCCCCTAGGATTCTCTGAAGC
1281 ACCCTGGTGTCCTGGCTGTGAATTCAAGTCCCATCTTTACTTATTTGGTGTGGGTCCTCCCTCTGAGCCGGTTTTCTCAT
1361 CTACAAAATGAAGACAACAGTACTTCCCTCCTGGGATCATTGAAAGATTTAGGGAGCATATCCTTCCACTTCCCAAACAT
1441 ATTTGAACCTCTGACTTGCTTAGGAGCATCATTCAAATCACAGATCCCCCAGTATCTAGTCCCAACCTATTGAATCAGGA
1521 TCCCCAGGGAAGGAGGAGCTTGGGAATCTGATTTTTTTTTTTTTTTTTAGATAAAGTCTCACTCTGTCACCCAGGCTTGA
1601 GTGCAGTGGCAAAATCTTGGCTCATTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCATGCCTCAGCTTCCCGACATA
1681 GCTGGGATTATAGGCGTGCACCACCATGCCCAGCTAATTTTTCGTTGTTGTTGTTGTTGTTTTGTTTTTGAGACAGAGTC
1761 TCGCTCTGTTGCCCAGGCTGGAGTACAGTGGCACGATCTTGGCTCACTGCAAGCTCCGCTTCCCGGGTTCACGCCATTCT
1841 CCTGCCTCAGCCTCCCGAGTAGCTGGGACCACAGGTGCCCGCCACCACGCCCGGCTAATTTTTTTGGTATTTTTAGTAGA
1921 GACGGGGTTTTACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCTCCCGCCTCGGCCTCCCAAAGTGCT
2001 GGCATTACAGGCGTGAGCCATCATTCCTGGCTGGGAATCCGAATTTTTTTTTTTTTTTAGACGGAGTTTCGCTCTTGTTG
2081 CCCAGGCTGGAGTTCAATAGCATGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCTAG
2161 CTGGGATTGCAGGCGCCCACGACCACGCCCAGCTAATTTTTGTATTTTGTAGTAGAGACGGGATTTCGCCATATTGGCCA
2241 GGCCATAGTGGTCTTGGACTCCTGACCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGTTGGGTTTACAGGCGTGAG
2321 CTACCATACCCTGCCCAGGAATCTGAATTTTTAGCAATCAGTTAGCAGCAAATAAGCTGAGATTTCCTGGGTACTAAGCA
2401 CATACTATGAGCATTACAGCCGCTTTATATAAGCTCGTTCACTGTCCTCATTACATTCCTAATATGCAAGTGAGCATGTT
2481 TTTTAATCCTCAGTCTAGAGGTGAGGAAACTGAGGCAGGCACAGAGAGGCTAAGGGATTTGCCTAGTCGCACAGCTAGGA
2561 AGGTGCAGCACTGAGACTCGAATCCACACAGCTTGGCTTAAGTCTACCATTAAATTTGCCTGTCCTGGCCAGGTGCGGTG
2641 GCTCACGCCTGTAATCCCAACACTTCGTGAGGCCAAGGCAGGTGGATCACTTGAAGTGAGGAGTTCGAGACCACACCAGC
2721 CTGGCCAACATGGTGAAATCCCGTCTTTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGTGCCGGTAATCCTA
2801 GCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAACCGAGATTGCGCCACTAGA
2881 CTCCAGCCTGGGAGACGAGCAAAACTGTCTCAAAAAAATAAAATGAAATACATAAATAAATGTGCCTATCCTGTGCCGGG
2961 TGCTGTTCTTGCCAGTGGGGATACATGAGAGAACACTGCCTTGCCCGCATGAGGCTTGTGGCCTGGTACTGTGCACACCT
3041 CAGGGGATTCTGATAATTAGCTGAGCACAGTTGCCAGCACAGGGCCTGGCTCAATAAATATTAGCTGCTGGCTTCTGCTC
3121 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacaccCUCGGUGUCCCACGAc 5'
                | |||   ||||||| 
Target 5' tatcctGTGCC---GGGTGCTg 3'
 2947 - 2965 145.00 -19.80
2 
miRNA  3' gacACCCUCGGUGU--CCCACGac 5'
             |||| |: :::  ||||||  
Target 5' agcTGGGCGTGGTGGTGGGTGCcg 3'
 2768 - 2791 133.00 -17.20
3 
miRNA  3' gacACCCUCGGUGUCCCACGAc 5'
             || || :: | |||| || 
Target 5' agcTGAGATTTCCTGGGTACTa 3'
 2375 - 2396 123.00 -10.66
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM234060 4 COSMIC
COSM8075698 20 COSMIC
COSM8536184 20 COSMIC
COSM3680909 25 COSMIC
COSM7846196 36 COSMIC
COSM8348083 57 COSMIC
COSN30582512 97 COSMIC
COSN31492036 98 COSMIC
COSN8260376 108 COSMIC
COSN31515614 135 COSMIC
COSN31506435 138 COSMIC
COSN31499940 141 COSMIC
COSN26635890 153 COSMIC
COSN31500017 166 COSMIC
COSN19771652 174 COSMIC
COSN20115788 181 COSMIC
COSN31603036 207 COSMIC
COSN29431167 248 COSMIC
COSN31549374 299 COSMIC
COSN22574371 404 COSMIC
COSN32012901 471 COSMIC
COSN17527045 477 COSMIC
COSN28404077 841 COSMIC
COSN8260377 958 COSMIC
COSN21878474 1393 COSMIC
COSN21777424 1418 COSMIC
COSN18772881 1569 COSMIC
COSN8260378 1764 COSMIC
COSN26260953 1797 COSMIC
COSN28136101 1924 COSMIC
COSN9357222 1995 COSMIC
COSN22729469 2213 COSMIC
COSN20829836 2233 COSMIC
COSN29696764 2363 COSMIC
COSN9357223 2565 COSMIC
COSN8260379 2758 COSMIC
COSN24521800 2869 COSMIC
COSN15029620 2883 COSMIC
COSN20706401 2898 COSMIC
COSN5437916 3077 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776309713 1 dbSNP
rs1444660653 2 dbSNP
rs745320615 5 dbSNP
rs769253842 6 dbSNP
rs1409844312 10 dbSNP
rs900166283 11 dbSNP
rs774687398 12 dbSNP
rs942072365 13 dbSNP
rs1479320577 17 dbSNP
rs1171804188 19 dbSNP
rs570068330 20 dbSNP
rs1425735929 21 dbSNP
rs56845315 25 dbSNP
rs897939829 26 dbSNP
rs929400733 27 dbSNP
rs773499748 29 dbSNP
rs559057404 33 dbSNP
rs760919255 38 dbSNP
rs766541856 39 dbSNP
rs1309431569 48 dbSNP
rs771432098 49 dbSNP
rs753968979 53 dbSNP
rs1027583416 54 dbSNP
rs754985204 55 dbSNP
rs1004760527 59 dbSNP
rs765288081 64 dbSNP
rs1274625659 67 dbSNP
rs752568954 79 dbSNP
rs758301247 83 dbSNP
rs777711093 84 dbSNP
rs571011989 85 dbSNP
rs535271906 88 dbSNP
rs780968079 89 dbSNP
rs1478918667 90 dbSNP
rs1166081515 93 dbSNP
rs1389520878 94 dbSNP
rs745421332 107 dbSNP
rs773893152 108 dbSNP
rs1363291599 109 dbSNP
rs774979189 111 dbSNP
rs748608344 118 dbSNP
rs1333179348 119 dbSNP
rs772592042 121 dbSNP
rs773591527 125 dbSNP
rs761007377 127 dbSNP
rs1254015244 133 dbSNP
rs959415815 135 dbSNP
rs192145062 136 dbSNP
rs371530075 138 dbSNP
rs575160293 139 dbSNP
rs548215339 146 dbSNP
rs1316965531 151 dbSNP
rs183846091 155 dbSNP
rs1341326970 160 dbSNP
rs1018312381 162 dbSNP
rs771710894 165 dbSNP
rs1303894914 171 dbSNP
rs904768429 174 dbSNP
rs111585731 177 dbSNP
rs16746 177 dbSNP
rs397727613 177 dbSNP
rs866132805 180 dbSNP
rs371339173 181 dbSNP
rs374274383 182 dbSNP
rs376132301 187 dbSNP
rs1426990694 195 dbSNP
rs1288183224 200 dbSNP
rs1042567331 207 dbSNP
rs1431635458 209 dbSNP
rs373736940 214 dbSNP
rs1347025683 217 dbSNP
rs376646839 218 dbSNP
rs371506042 223 dbSNP
rs1395854382 226 dbSNP
rs545577999 227 dbSNP
rs57689270 235 dbSNP
rs1204352904 243 dbSNP
rs1187603865 247 dbSNP
rs900220403 249 dbSNP
rs760153115 250 dbSNP
rs1243354323 254 dbSNP
rs1207346185 257 dbSNP
rs1280549953 260 dbSNP
rs995883065 260 dbSNP
rs1048737534 264 dbSNP
rs187034800 274 dbSNP
rs970968048 275 dbSNP
rs1181200522 276 dbSNP
rs1242062599 280 dbSNP
rs1444534943 290 dbSNP
rs980624971 292 dbSNP
rs926573515 295 dbSNP
rs963248944 298 dbSNP
rs973272342 303 dbSNP
rs919273523 304 dbSNP
rs1053664 308 dbSNP
rs1004813035 310 dbSNP
rs1014811628 314 dbSNP
rs528994913 320 dbSNP
rs1171488682 321 dbSNP
rs1430827825 326 dbSNP
rs1412199224 327 dbSNP
rs1185202582 333 dbSNP
rs1158355613 334 dbSNP
rs1003091146 336 dbSNP
rs540065744 340 dbSNP
rs1035140738 353 dbSNP
rs1485042201 360 dbSNP
rs911978351 373 dbSNP
rs561567514 374 dbSNP
rs529118299 385 dbSNP
rs550860448 390 dbSNP
rs1334777260 394 dbSNP
rs943567872 395 dbSNP
rs1039207524 399 dbSNP
rs1309203341 403 dbSNP
rs1447397256 406 dbSNP
rs1311303522 408 dbSNP
rs959702691 409 dbSNP
rs149542925 422 dbSNP
rs1356164135 429 dbSNP
rs1333938741 432 dbSNP
rs1295424077 440 dbSNP
rs1408242004 442 dbSNP
rs1395974133 446 dbSNP
rs904799603 451 dbSNP
rs530979394 452 dbSNP
rs1053334839 469 dbSNP
rs1164809381 473 dbSNP
rs915234757 476 dbSNP
rs967987133 477 dbSNP
rs978315326 483 dbSNP
rs754327431 487 dbSNP
rs892131992 488 dbSNP
rs762922987 490 dbSNP
rs145990237 491 dbSNP
rs1249318553 496 dbSNP
rs1177598112 501 dbSNP
rs1025181725 502 dbSNP
rs1040927542 511 dbSNP
rs1002472485 515 dbSNP
rs1180007968 516 dbSNP
rs921723464 517 dbSNP
rs1417865394 524 dbSNP
rs1181514963 527 dbSNP
rs931718376 528 dbSNP
rs963154102 543 dbSNP
rs191278982 544 dbSNP
rs1365909479 553 dbSNP
rs184519704 556 dbSNP
rs553573236 557 dbSNP
rs1397251815 558 dbSNP
rs1166490477 562 dbSNP
rs765580098 575 dbSNP
rs907102089 577 dbSNP
rs1209292691 578 dbSNP
rs987482119 585 dbSNP
rs1405653742 587 dbSNP
rs1362900373 588 dbSNP
rs1182051339 590 dbSNP
rs568682921 590 dbSNP
rs535730189 591 dbSNP
rs943448134 592 dbSNP
rs752990203 599 dbSNP
rs1394234901 612 dbSNP
rs1468881008 617 dbSNP
rs1039112842 630 dbSNP
rs926120576 648 dbSNP
rs936118147 657 dbSNP
rs1261595206 664 dbSNP
rs1053366254 668 dbSNP
rs1034594987 674 dbSNP
rs1301682602 683 dbSNP
rs1345909990 686 dbSNP
rs557684729 691 dbSNP
rs1303146338 700 dbSNP
rs895266112 702 dbSNP
rs575123610 704 dbSNP
rs1221490300 710 dbSNP
rs1012293535 715 dbSNP
rs1022296298 716 dbSNP
rs1046049217 719 dbSNP
rs906169586 721 dbSNP
rs138682513 722 dbSNP
rs557410448 723 dbSNP
rs572574679 727 dbSNP
rs539954860 731 dbSNP
rs190578222 734 dbSNP
rs573782260 735 dbSNP
rs1033357293 737 dbSNP
rs1396869340 740 dbSNP
rs780364921 744 dbSNP
rs1190923275 748 dbSNP
rs963186577 754 dbSNP
rs141585236 755 dbSNP
rs1031278936 763 dbSNP
rs1374960215 765 dbSNP
rs1195768355 766 dbSNP
rs1268466090 780 dbSNP
rs966675507 790 dbSNP
rs1026222555 791 dbSNP
rs1350474857 792 dbSNP
rs976314232 794 dbSNP
rs1227351394 805 dbSNP
rs117008859 819 dbSNP
rs3746079 820 dbSNP
rs965041270 823 dbSNP
rs146211657 828 dbSNP
rs908935078 830 dbSNP
rs1435170458 836 dbSNP
rs866510556 837 dbSNP
rs1036012982 838 dbSNP
rs907157966 845 dbSNP
rs1475049336 846 dbSNP
rs938590809 847 dbSNP
rs1373521166 850 dbSNP
rs564490871 852 dbSNP
rs936191256 853 dbSNP
rs1257137566 854 dbSNP
rs1211849455 858 dbSNP
rs367746016 864 dbSNP
rs10409917 866 dbSNP
rs568668896 867 dbSNP
rs950349965 870 dbSNP
rs1046377598 874 dbSNP
rs1219994131 880 dbSNP
rs536088828 898 dbSNP
rs550977465 899 dbSNP
rs898911452 900 dbSNP
rs1409109229 903 dbSNP
rs1397174659 908 dbSNP
rs370421655 918 dbSNP
rs1031415510 920 dbSNP
rs1459994531 921 dbSNP
rs1340726023 926 dbSNP
rs1216025986 930 dbSNP
rs1188679474 940 dbSNP
rs1476323455 942 dbSNP
rs1026129338 950 dbSNP
rs539766598 955 dbSNP
rs1181591243 956 dbSNP
rs976745227 960 dbSNP
rs886247074 965 dbSNP
rs1029225364 970 dbSNP
rs1334697998 971 dbSNP
rs1271999618 973 dbSNP
rs1019242667 974 dbSNP
rs1380926094 975 dbSNP
rs1306464086 981 dbSNP
rs1244910571 991 dbSNP
rs1293085652 1000 dbSNP
rs1277373819 1003 dbSNP
rs1441272769 1006 dbSNP
rs1333359171 1009 dbSNP
rs1336113699 1009 dbSNP
rs779860905 1011 dbSNP
rs964708389 1022 dbSNP
rs1165791822 1032 dbSNP
rs115015772 1033 dbSNP
rs1406123724 1034 dbSNP
rs182231306 1035 dbSNP
rs10408589 1038 dbSNP
rs1188558358 1039 dbSNP
rs957425683 1049 dbSNP
rs555088136 1052 dbSNP
rs908985844 1053 dbSNP
rs988873655 1054 dbSNP
rs913414866 1055 dbSNP
rs1359841497 1056 dbSNP
rs1165581268 1067 dbSNP
rs950230957 1068 dbSNP
rs1386956714 1070 dbSNP
rs981720372 1071 dbSNP
rs1222844433 1073 dbSNP
rs940420651 1078 dbSNP
rs927535061 1079 dbSNP
rs1370208908 1080 dbSNP
rs1360970052 1081 dbSNP
rs573742827 1082 dbSNP
rs1286706320 1084 dbSNP
rs544427400 1097 dbSNP
rs971758056 1099 dbSNP
rs937713042 1100 dbSNP
rs928296446 1103 dbSNP
rs938319865 1106 dbSNP
rs562615630 1108 dbSNP
rs375569725 1113 dbSNP
rs947249285 1121 dbSNP
rs1042850562 1134 dbSNP
rs1454081443 1135 dbSNP
rs1396256420 1136 dbSNP
rs930413969 1139 dbSNP
rs1047906126 1140 dbSNP
rs1239864515 1149 dbSNP
rs1396037249 1149 dbSNP
rs1214381998 1150 dbSNP
rs886280695 1154 dbSNP
rs1287682757 1156 dbSNP
rs1009105065 1159 dbSNP
rs903984232 1164 dbSNP
rs1247929967 1166 dbSNP
rs1018900982 1168 dbSNP
rs999555892 1170 dbSNP
rs542733442 1176 dbSNP
rs996205075 1183 dbSNP
rs1033031440 1184 dbSNP
rs1311263459 1199 dbSNP
rs1291474151 1209 dbSNP
rs1376439892 1211 dbSNP
rs1178598339 1213 dbSNP
rs1427271274 1228 dbSNP
rs1419379097 1230 dbSNP
rs1185473712 1238 dbSNP
rs1317847844 1241 dbSNP
rs372643534 1246 dbSNP
rs901860893 1246 dbSNP
rs957330873 1246 dbSNP
rs1259120815 1249 dbSNP
rs997499699 1255 dbSNP
rs1208277699 1257 dbSNP
rs1029689914 1267 dbSNP
rs1485104631 1268 dbSNP
rs1280802349 1279 dbSNP
rs773257361 1281 dbSNP
rs953591895 1284 dbSNP
rs12980577 1285 dbSNP
rs1006434100 1289 dbSNP
rs1215288156 1291 dbSNP
rs1245110580 1292 dbSNP
rs12980992 1296 dbSNP
rs561508426 1297 dbSNP
rs1291735657 1299 dbSNP
rs1414402017 1329 dbSNP
rs1442663495 1331 dbSNP
rs1010330367 1334 dbSNP
rs778837879 1341 dbSNP
rs1460760297 1349 dbSNP
rs1182960144 1350 dbSNP
rs577836875 1351 dbSNP
rs1020748856 1360 dbSNP
rs1402190512 1377 dbSNP
rs1425158353 1382 dbSNP
rs971629526 1386 dbSNP
rs962170688 1389 dbSNP
rs767341433 1393 dbSNP
rs982010113 1400 dbSNP
rs1474690454 1409 dbSNP
rs927578857 1412 dbSNP
rs1183417427 1417 dbSNP
rs972225540 1422 dbSNP
rs1156670828 1429 dbSNP
rs545333682 1435 dbSNP
rs1205129088 1439 dbSNP
rs1319823765 1443 dbSNP
rs564428146 1456 dbSNP
rs1344178618 1467 dbSNP
rs1271361951 1469 dbSNP
rs1466294208 1475 dbSNP
rs974272123 1480 dbSNP
rs920272873 1483 dbSNP
rs959988704 1484 dbSNP
rs1338094566 1490 dbSNP
rs1390084986 1507 dbSNP
rs991155801 1511 dbSNP
rs915850381 1528 dbSNP
rs1449671898 1537 dbSNP
rs947301770 1546 dbSNP
rs1042903001 1549 dbSNP
rs1460435793 1551 dbSNP
rs1178957559 1552 dbSNP
rs1249562631 1552 dbSNP
rs34521090 1552 dbSNP
rs569632833 1552 dbSNP
rs1459050780 1554 dbSNP
rs1251016748 1565 dbSNP
rs397742901 1569 dbSNP
rs1314920005 1570 dbSNP
rs528543664 1571 dbSNP
rs1237160374 1577 dbSNP
rs907612802 1578 dbSNP
rs1242722553 1579 dbSNP
rs1369484531 1585 dbSNP
rs148439185 1590 dbSNP
rs1439594772 1601 dbSNP
rs1282671985 1605 dbSNP
rs934472924 1606 dbSNP
rs1316548782 1607 dbSNP
rs1451193630 1609 dbSNP
rs1040596066 1610 dbSNP
rs900316131 1611 dbSNP
rs1052964393 1616 dbSNP
rs771757585 1626 dbSNP
rs1265053481 1636 dbSNP
rs901916266 1641 dbSNP
rs1054341795 1675 dbSNP
rs185776840 1676 dbSNP
rs529445330 1696 dbSNP
rs540856822 1697 dbSNP
rs1219309032 1701 dbSNP
rs1346150445 1703 dbSNP
rs889405893 1705 dbSNP
rs141619547 1715 dbSNP
rs368175320 1718 dbSNP
rs962221281 1721 dbSNP
rs1034497791 1724 dbSNP
rs1302792835 1724 dbSNP
rs755693756 1724 dbSNP
rs993651337 1725 dbSNP
rs1373400834 1727 dbSNP
rs1172722681 1729 dbSNP
rs1035875754 1730 dbSNP
rs1379259529 1737 dbSNP
rs1478329905 1737 dbSNP
rs1191174757 1738 dbSNP
rs1427976043 1740 dbSNP
rs760206221 1742 dbSNP
rs959797002 1743 dbSNP
rs1178083677 1744 dbSNP
rs1403483760 1755 dbSNP
rs188936890 1758 dbSNP
rs1201339234 1761 dbSNP
rs915568977 1763 dbSNP
rs1250093952 1764 dbSNP
rs1224685584 1767 dbSNP
rs1331462502 1777 dbSNP
rs968319135 1786 dbSNP
rs1401479557 1792 dbSNP
rs1353131141 1793 dbSNP
rs1355615573 1794 dbSNP
rs566126626 1795 dbSNP
rs974303069 1796 dbSNP
rs924504424 1814 dbSNP
rs1373114503 1818 dbSNP
rs934520233 1819 dbSNP
rs1285385678 1821 dbSNP
rs868214174 1824 dbSNP
rs373558459 1825 dbSNP
rs1474361552 1826 dbSNP
rs251860 1828 dbSNP
rs1273872523 1829 dbSNP
rs1188730465 1831 dbSNP
rs933412209 1833 dbSNP
rs1050907602 1834 dbSNP
rs983513593 1839 dbSNP
rs1195738875 1840 dbSNP
rs1319145814 1857 dbSNP
rs907643494 1858 dbSNP
rs889124632 1871 dbSNP
rs941986008 1877 dbSNP
rs573706649 1881 dbSNP
rs1037970382 1882 dbSNP
rs1342033623 1883 dbSNP
rs898066373 1889 dbSNP
rs994093419 1890 dbSNP
rs1445968709 1893 dbSNP
rs76128311 1894 dbSNP
rs575077356 1899 dbSNP
rs895587068 1900 dbSNP
rs760147219 1910 dbSNP
rs1010266530 1914 dbSNP
rs1164046588 1924 dbSNP
rs1473860546 1925 dbSNP
rs113886874 1928 dbSNP
rs968369710 1932 dbSNP
rs978387310 1935 dbSNP
rs1411089527 1936 dbSNP
rs907177548 1944 dbSNP
rs1412107067 1951 dbSNP
rs1003383188 1955 dbSNP
rs185689275 1956 dbSNP
rs955981348 1961 dbSNP
rs1288782346 1969 dbSNP
rs1228534819 1970 dbSNP
rs977026048 1974 dbSNP
rs1027226793 1977 dbSNP
rs545321296 1978 dbSNP
rs145677474 1980 dbSNP
rs932437896 1981 dbSNP
rs549090310 1983 dbSNP
rs1438873839 1985 dbSNP
rs1349375603 1986 dbSNP
rs986231635 1993 dbSNP
rs910609961 1997 dbSNP
rs573261019 1999 dbSNP
rs1341501321 2000 dbSNP
rs1212917245 2004 dbSNP
rs1272124775 2005 dbSNP
rs1360093600 2008 dbSNP
rs942038361 2009 dbSNP
rs1037686671 2013 dbSNP
rs147708593 2014 dbSNP
rs898109154 2016 dbSNP
rs1192308427 2027 dbSNP
rs1454166239 2028 dbSNP
rs1245634878 2030 dbSNP
rs1266598206 2033 dbSNP
rs929563922 2034 dbSNP
rs1490076395 2041 dbSNP
rs1057495838 2042 dbSNP
rs1193510623 2042 dbSNP
rs1215687479 2044 dbSNP
rs1366762074 2044 dbSNP
rs59475599 2044 dbSNP
rs796256039 2044 dbSNP
rs965709225 2044 dbSNP
rs1243508177 2045 dbSNP
rs1474116685 2057 dbSNP
rs975833619 2058 dbSNP
rs1297811645 2059 dbSNP
rs1390035734 2059 dbSNP
rs921679152 2061 dbSNP
rs1362846735 2063 dbSNP
rs1165856485 2064 dbSNP
rs1364151869 2065 dbSNP
rs1426437552 2071 dbSNP
rs1404746045 2074 dbSNP
rs764885520 2078 dbSNP
rs1319184905 2085 dbSNP
rs112536038 2094 dbSNP
rs1013475029 2099 dbSNP
rs1428655065 2105 dbSNP
rs1488380569 2110 dbSNP
rs563141583 2111 dbSNP
rs1208412930 2114 dbSNP
rs1311575326 2123 dbSNP
rs914519332 2136 dbSNP
rs1383438067 2137 dbSNP
rs945973386 2149 dbSNP
rs1289291892 2151 dbSNP
rs1277578345 2152 dbSNP
rs1358397556 2154 dbSNP
rs1205532138 2156 dbSNP
rs1342550733 2173 dbSNP
rs1285831679 2174 dbSNP
rs144867395 2175 dbSNP
rs1191825658 2176 dbSNP
rs907204814 2181 dbSNP
rs563051835 2182 dbSNP
rs753156123 2184 dbSNP
rs1445733357 2187 dbSNP
rs999859814 2188 dbSNP
rs1383956640 2195 dbSNP
rs1477962225 2199 dbSNP
rs1031290693 2220 dbSNP
rs955864791 2221 dbSNP
rs1387401892 2223 dbSNP
rs976700164 2228 dbSNP
rs1029971578 2229 dbSNP
rs1319940796 2230 dbSNP
rs995657514 2233 dbSNP
rs1219282465 2239 dbSNP
rs1320320230 2246 dbSNP
rs1291643167 2247 dbSNP
rs1395867908 2255 dbSNP
rs1380344160 2256 dbSNP
rs1454666460 2257 dbSNP
rs1178781191 2260 dbSNP
rs1304890143 2267 dbSNP
rs1312776150 2270 dbSNP
rs1027089963 2277 dbSNP
rs530600590 2280 dbSNP
rs1239424704 2284 dbSNP
rs1465671587 2285 dbSNP
rs1281128396 2288 dbSNP
rs1162257028 2289 dbSNP
rs953915241 2291 dbSNP
rs1004881219 2292 dbSNP
rs1414280088 2296 dbSNP
rs1348094698 2302 dbSNP
rs985277302 2309 dbSNP
rs1237459087 2316 dbSNP
rs114525276 2317 dbSNP
rs1459133571 2318 dbSNP
rs963454173 2323 dbSNP
rs973432870 2324 dbSNP
rs1462237004 2331 dbSNP
rs1315308899 2335 dbSNP
rs1201237393 2337 dbSNP
rs919270891 2338 dbSNP
rs929258520 2340 dbSNP
rs1241776432 2360 dbSNP
rs1446972801 2364 dbSNP
rs1401853683 2365 dbSNP
rs566856434 2369 dbSNP
rs1350064415 2370 dbSNP
rs975738752 2370 dbSNP
rs1166699055 2373 dbSNP
rs1028775736 2394 dbSNP
rs1057389524 2414 dbSNP
rs78287148 2418 dbSNP
rs948915855 2420 dbSNP
rs1044543058 2422 dbSNP
rs190402523 2423 dbSNP
rs999910509 2424 dbSNP
rs1214982666 2427 dbSNP
rs1158638961 2435 dbSNP
rs1053242834 2437 dbSNP
rs1407148021 2438 dbSNP
rs368228759 2439 dbSNP
rs1310367193 2441 dbSNP
rs567162558 2447 dbSNP
rs180825910 2451 dbSNP
rs1029607742 2455 dbSNP
rs1298592923 2466 dbSNP
rs1385698875 2474 dbSNP
rs1401392220 2484 dbSNP
rs1367923114 2492 dbSNP
rs954080463 2507 dbSNP
rs556033597 2509 dbSNP
rs1417701376 2511 dbSNP
rs1006767856 2515 dbSNP
rs1359667213 2518 dbSNP
rs1158964479 2529 dbSNP
rs1016767504 2531 dbSNP
rs962500766 2533 dbSNP
rs973485180 2534 dbSNP
rs186060267 2535 dbSNP
rs1333814299 2549 dbSNP
rs75283644 2550 dbSNP
rs751766011 2565 dbSNP
rs993220589 2566 dbSNP
rs938717013 2577 dbSNP
rs1055707369 2580 dbSNP
rs191107597 2581 dbSNP
rs917548984 2593 dbSNP
rs948968208 2596 dbSNP
rs1231968167 2600 dbSNP
rs1044591460 2602 dbSNP
rs931414491 2607 dbSNP
rs1221142471 2615 dbSNP
rs1048432656 2618 dbSNP
rs757428899 2619 dbSNP
rs1339391451 2625 dbSNP
rs1298623312 2637 dbSNP
rs767697593 2642 dbSNP
rs183693462 2647 dbSNP
rs1400050705 2648 dbSNP
rs111491833 2649 dbSNP
rs1466423843 2664 dbSNP
rs1379456663 2665 dbSNP
rs148962475 2667 dbSNP
rs1477633929 2669 dbSNP
rs1264137540 2673 dbSNP
rs1196361443 2678 dbSNP
rs1441039311 2679 dbSNP
rs1256154241 2681 dbSNP
rs1052888181 2683 dbSNP
rs568595785 2692 dbSNP
rs1041729337 2694 dbSNP
rs1264484242 2699 dbSNP
rs1436388612 2707 dbSNP
rs997883711 2708 dbSNP
rs544689055 2717 dbSNP
rs1229421340 2726 dbSNP
rs1338488753 2727 dbSNP
rs901412341 2730 dbSNP
rs1404208292 2733 dbSNP
rs1329443515 2734 dbSNP
rs1465153289 2740 dbSNP
rs1424682425 2742 dbSNP
rs562881037 2743 dbSNP
rs1051198517 2744 dbSNP
rs1481573271 2750 dbSNP
rs1368268197 2752 dbSNP
rs143642388 2755 dbSNP
rs1377177930 2757 dbSNP
rs545224016 2759 dbSNP
rs1236861639 2760 dbSNP
rs1462412787 2761 dbSNP
rs1196274507 2768 dbSNP
rs1299775193 2770 dbSNP
rs1394254807 2771 dbSNP
rs1006817127 2776 dbSNP
rs1303598995 2777 dbSNP
rs560332542 2780 dbSNP
rs1245202753 2782 dbSNP
rs1306979261 2788 dbSNP
rs527942570 2791 dbSNP
rs151041394 2792 dbSNP
rs778689939 2793 dbSNP
rs251859 2796 dbSNP
rs962553370 2799 dbSNP
rs967656235 2808 dbSNP
rs993989607 2809 dbSNP
rs1026424140 2810 dbSNP
rs1307521290 2811 dbSNP
rs1473971109 2816 dbSNP
rs950862339 2822 dbSNP
rs992879461 2833 dbSNP
rs1229010439 2840 dbSNP
rs977274666 2844 dbSNP
rs1024735922 2847 dbSNP
rs969992389 2851 dbSNP
rs959927978 2857 dbSNP
rs1205954534 2858 dbSNP
rs980340098 2864 dbSNP
rs1210274615 2865 dbSNP
rs1270131710 2872 dbSNP
rs758146334 2873 dbSNP
rs931276964 2878 dbSNP
rs531250798 2879 dbSNP
rs936200419 2882 dbSNP
rs1377488282 2883 dbSNP
rs1281381989 2887 dbSNP
rs1434358424 2888 dbSNP
rs1048997837 2890 dbSNP
rs251858 2892 dbSNP
rs913020023 2897 dbSNP
rs1429128889 2898 dbSNP
rs1158365457 2910 dbSNP
rs144888833 2911 dbSNP
rs1382665655 2912 dbSNP
rs1178478158 2920 dbSNP
rs1050829215 2933 dbSNP
rs538761591 2934 dbSNP
rs553975076 2937 dbSNP
rs901318832 2943 dbSNP
rs997115695 2946 dbSNP
rs1283652928 2947 dbSNP
rs942317782 2954 dbSNP
rs1038305645 2958 dbSNP
rs369769987 2959 dbSNP
rs888785664 2970 dbSNP
rs1217612759 2974 dbSNP
rs756195205 2975 dbSNP
rs1275450744 2981 dbSNP
rs1407017389 2983 dbSNP
rs1338654153 2987 dbSNP
rs1367272812 2999 dbSNP
rs994056875 3001 dbSNP
rs1021826469 3007 dbSNP
rs538963539 3008 dbSNP
rs1292544827 3009 dbSNP
rs1414336572 3016 dbSNP
rs1423876790 3037 dbSNP
rs1362226190 3053 dbSNP
rs1176460278 3054 dbSNP
rs999116197 3066 dbSNP
rs770474610 3067 dbSNP
rs1014758305 3072 dbSNP
rs1192732802 3072 dbSNP
rs1024320261 3085 dbSNP
rs970046056 3088 dbSNP
rs1243565473 3107 dbSNP
rs73547970 3111 dbSNP
rs868600550 3114 dbSNP
rs73547972 3119 dbSNP
rs1292930588 3121 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1
Disease MIMAT0027643
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccucgguguccCACGac 5'
                          ||||  
Target 5' -------gccuauccuGUGCcg 3'
 		1 - 15
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000425673.1 | 3UTR | GCCUAUCCUGUGCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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